LOCUS       AB812053               21385 bp    DNA     linear   BCT 13-MAY-2015
DEFINITION  Escherichia coli genes for O-antigen biosynthetic locus, partial
            sequence, strain: Ew2129-54.
ACCESSION   AB812053
VERSION     AB812053.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. 22 (1), 101-107 (2015)
   PUBMED   25428893
  REMARK    DOI:10.1093/dnares/dsu043
REFERENCE   2  (bases 1 to 21385)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..21385
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="Ew2129-54"
                     /db_xref="taxon:562"
                     /note="serogroup:O125"
     gene            <1..904
                     /gene="wcaM"
     CDS             <1..904
                     /gene="wcaM"
                     /codon_start=2
                     /transl_table=11
                     /product="colanic acid biosynthesis protein"
                     /protein_id="BAQ01592.1"
                     /translation="YAILRQGFHNQIIGANITNCKFSDLRGDAIEWNVAINDSDILIS
                     DHVIERINCTNGKINWGIGIGLAGSTYDNNYPENQAVKNFVVANITGSDCRQLIHVEN
                     GKHFVIRNIKARNITPNFSKKAGIDNATVAIYGCDNFGIDNIEMINSAGMLIGYGVIK
                     GKYLSIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKP
                     QHLFMRNIKVMQESSVGAALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNEKGQSSV
                     DIDRINHHIVNVEKINFRLPERRE"
     gene            1062..2057
                     /gene="gne"
     CDS             1062..2057
                     /gene="gnu"
                     /note="O125_01"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 4-epimerase"
                     /protein_id="BAQ01593.1"
                     /translation="MNDNVLLIGASGFVGTRLLETAIADFNIKNLDKQQSHFYPEITQ
                     IGDVRDQQALDQALAGFDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVK
                     NIIFTSSVAVYGLNKHNPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIR
                     PTVIFGERNRGNVYNLLKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGY
                     EVYNYVDKPDLNMNQLVAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAV
                     SSVRVKKFCATTQFDATKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE"
     gene            2296..3192
                     /gene="galF"
     CDS             2296..3192
                     /gene="galF"
                     /note="O125_02"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ01594.1"
                     /translation="MMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDE
                     IVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMN
                     VRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGR
                     SQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVL
                     SADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVK
                     YGLRNLKEGAKFRKGIEKLLRE"
     gene            3546..4817
                     /gene="wzx"
     CDS             3546..4817
                     /gene="wzx"
                     /note="O125_03"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAQ01595.1"
                     /translation="MKVYNVFILNGLSVFVKMATLLGLNKVFAIYLGTSGYALIGQIQ
                     NILNIAMVAPSQAISTSIVKYTSEYKNSNKEKIWSFWINAIYLSTIMGFITAVIIIIF
                     KNIIIEQFFNSNDKVSIAIYFLGGSVILYAWNNIILSMLNGLSFIKNYIWINIISSLI
                     SAIYAFILTISFGMRGALIAVVSNQAILFFVTFFYSKKYLREYYVNNCNRIDISILKR
                     IIIFSLMTVTSAILVPVSTLYVRNEIITSINIEYAGLWDAVNRISSVYLMLITTTLGI
                     YFFPRFSSASNRSELLNEIKVCYLYLVPLVCISSVLMYTFRGLIVNILFTHEFVPIVD
                     VIVYQLIGDFFKIIAWVLGYLLISKAFVKEYIVLEVLQWSVYCILSKYSLCYVENAQI
                     SYVFKAYIISQALYMFSLIVTICYLLNKNKV"
     CDS             4824..5744
                     /note="O125_04"
                     /gene="wetD"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01596.1"
                     /translation="MINKNKVSVIIPVYNAEKYLGACIDSILEQTYKIFEIIIINDGS
                     QDGTQKILDEYKNKYPSIFKIKHRENKGIVATLNELLDMATGVYIARMDADDIAHRER
                     LRLQVEIMDADQKIACCGTNIKVFESAVNSGKIIKMPNSDEACKIGLLVGSCFAHPTV
                     MMRSSIIKKECLYYKPRYQYAEDYEFWSRLANYGKFCNINIPLLYYRNHGNQISNIKK
                     HIQADIHISIAIDNLKKQGIILDKDELGMVLFPQSSHRFLNAICYYFKVYFIIFSKLG
                     VKIKYINCVFLRKFAYYCKIKINSILKKGY"
     CDS             5746..6591
                     /note="O125_05"
                     /gene="wetE"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01597.1"
                     /translation="MNNFYKISLIGTTQGGRDKEIERLLNSVASSTYKNLEIIFIDQT
                     DDIIIEQLFLKHAKNIKYKLVKSNKVPLSTARNQGLKLCSGNVIGFCDDDAFYAPDFF
                     EKVIQSNIKKETVLSVPVLDFQTMKSYANRVYPKTKKEMGYNQIIKSSLSVGTFIFTH
                     KLDNIYFDERLGVGTLFGGSEETELFFRLKSLGFRVCFQPIFGVYHDNDLYCEGIPEK
                     YRKYAVGYGVVIKKYLVKSRYLLLLEIFRITVKSFFGIVLKKQKKLYMYRLIGFWTGL
                     LKYDL"
     gene            6581..7903
                     /gene="wzy"
     CDS             6581..7903
                     /gene="wzy"
                     /note="O125_06"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAQ01598.1"
                     /translation="MIYKQYKLVLAQFYGFIGLIMIAVLSTSVKVEIDAILIWFLSVI
                     FTIAIIFFVYNRMWVWFDGMFIILSPFYFFVSFLLYYFFGVNVFNVENNIINTSFLYC
                     VAVWCIVASISLIRPHGINIFLLNKQYNYDNNYNLFIPSCIAWLISLFFLYQSRNLSL
                     NALGESTRLELINSVSQSGWYLKYVVIAYFWILLDLKVVKKNLTNYSFVIYSIPVLLY
                     FYTLMLVGSRREIALSFIMAVLLSLYKAKFKIPLKVALFSILFVSTIILFGIYRSDYN
                     VESSIRLLNALGEFIYPISTLQYYSSIHYQTQFFGISYLQFIVNFIPKELFMGLKPDT
                     LAIQFAKEVYLPSQEFMMGYAFTPFTEAFINYNYYGVIIFPAILCGYSYIMERLIGNN
                     YFLYLVFLSQSINFQRSEFSSMIFELGMFFMAYICLRLSMQIVFFKFK"
     CDS             7913..8926
                     /note="O125_07"
                     /gene="gne"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-glucose 4-epimerase"
                     /protein_id="BAQ01599.1"
                     /translation="MTILVTGGAGYIGSHTVLSLLEQNEDVVIIDNFSNSTEDIIKVI
                     SKLSGKKIRAYKVDLLDKKELKTIFTNHTFSKVLHFAGLKSVSESVQSPIRYYMNNIV
                     GLLNLLELMKIFHVNKIIFSSSATVYGLPETIPINEKCRIGETTNPYGTSKYYSEVIL
                     KDASLANPKLDVIILRYFNPVGAHESGLIGENPRGTPANLVPYMMNVALGKLPALTIY
                     GHDYPTPDGTGIRDYIHVNDLAEGHISAFKMFGKGGNYKIYNLGTGRGYSVLEVIKTF
                     QSIIGKNINYSFGPNRSGDVAECWADVSKAEKELDWKARRDLTEMLSSAWKWHTLNPD
                     GYN"
     CDS             8936..9970
                     /note="O125_08"
                     /gene="wdaF"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01600.1"
                     /translation="MPMLYLDGIIYSLQSYGGISVYYNQIIKAIKATNIEYTILNYEN
                     TGCQFISEDVRQPGRYINLYPRFLERYRAVDIPENSLLHSSYYRFNKGKKNKNITTVH
                     DFTYEKYMSGLRKYVHCHQKYNAIKNSDKIICISENTANDLLRYCPVPESKIEIIHNG
                     VSDNFYELKNVNYNDDDNFMLFIGSRKAYKNFQLAVEAINKLEGFKLYIVGGGPLGKA
                     EKFLLDKYIPYRYIHYPYLTEQELNLKFNQAHSLIYPSSYEGFGIPLLEAMRAGCPFI
                     AYNHSSIPEVAGDAGYLMDELSISNLIDGISFINRNRNQIIKKGLSQAQRFSWKKCTD
                     KTIDIYKKLL"
     gene            9981..11102
                     /gene="gmd"
     CDS             9981..11102
                     /gene="gmd"
                     /note="O125_09"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="BAQ01601.1"
                     /translation="MTKKALITGITGQDGSYLAEFLLNKGYEVHGIKRRSSIFNTGRI
                     DHIYQDPHNINLKLHLHYGDLTDTSNLTRILSEVQPDEVYNLGAMSHVAVSFESPEYT
                     ADVDAIGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEVPQKETTPFYPRSPYAVA
                     KLYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGIEKCLYL
                     GNMDSLRDWGHAKDYVRMQWMMLQQDQPEDFVIATGKQISVREFVRMSAKEVGLELEF
                     SGTGVDEIAMVVNKTSDCAVGVNIGDVIVRVDPRYFRPAEVETLLGDPTKAKNVLGWE
                     PEITVEEMCAEMVASDLEKAKQHALLKSHGFDVAVSLER"
     gene            11106..12071
                     /gene="fcl"
     CDS             11106..12071
                     /gene="fcl"
                     /note="O125_10"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-L-fucose synthetase"
                     /protein_id="BAQ01602.1"
                     /translation="MTKKRIFVAGHRGMVGSAICRQLLARNDVELIVKTHKELDLTVQ
                     KDVECFFEQERIDQVYLAAAKVGGIHANNTFPAEFIYQNLLIESNIIHSSYKAGIKKL
                     LFLGSSCIYPKFAEQPMKESALLTGTLEPTNEPYAISKIAGIKLCESYNRQYGCDYRS
                     VMPTNLYGMNDNFHPNNSHVIPALMRRFHEAKELGLNEVVVWGTGTPKREFLYVDDMA
                     AASVYVMELDDEIYKKNTQPMLSHINVGTGVDCSIREMAETMALVVGYDGKIVFDITK
                     PDGSPRKLMDVTRLENLGWKYRYNLKQGLELTYKWFINNLDSFRS"
     gene            12074..12529
                     /gene="gmm"
     CDS             12074..12529
                     /gene="gmm"
                     /note="O125_11"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosyl hydrolase"
                     /protein_id="BAQ01603.1"
                     /translation="MNKRLETELFKSIVEHTPLISIDLIIRNEDGKALLGQRLNRPAQ
                     NYWFVPGGRILKDESFENAFKRVTFEELGVQISINEAKFLGIYEHFYSDNFSGTCFST
                     HYVVHGYEISLMPHQINYPTLQHSTYNWFDIAELLANSSVHQYTKNYFK"
     gene            12541..13926
                     /gene="manC"
     CDS             12541..13926
                     /gene="manC"
                     /note="O125_12"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ01604.1"
                     /translation="MLLPVVMAGGSGTRLWPLSRTLYPKQFLSLTSRLTMLQETLRRL
                     EGVEHRPALVICNEVHRFIVAEQMRNVNLANSGILLEPIGRNTAPAVALAALKAISSG
                     EDPILLVLAADHEIQDQKRFISSILAAKEFAEEGKLVTFGIVPTKPETGYGYIKTGEN
                     LNEYGFKVSAFVEKPELDVAKKYLEDGDYLWNSGIFMFRASVFIDELNKFRPDILKIC
                     QQALKFSTQDLDFIRIDNDSFSCCPEESIDYAVMEKTTEAVVVPLNAHWSDVGSWSAL
                     WEISRKDKSGNAIRGDVLIHDSSDSYLYSQHRLIGVVGVKDLVVVETKDAILVAHKDK
                     VQQVKNIVEKLKVNNRTEYLQHREIFRPWGSHDSIAEGSRFEVKHVVIHPGHKTAKQI
                     HYHRTEHWIVVSGTAKVHYEDEIFLVSENESTYIPIGVPHFIENPGKIPLEIIEVRSG
                     VYLDEDDVVRI"
     CDS             13998..14756
                     /note="O125_13"
                     /gene="wdaG"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01605.1"
                     /translation="MDVKMKVSIITVTYNSEKTLRDTLESIELQTYKDIEYIIIDGGS
                     TDNTLKLINEVSTRVTKCLSESDNGIYDALNKGINLSTGDIIGFVHSDDLLARPDIIE
                     TIVSRFHETKADVVYGDLVFFEKNQIDIIKRYWRSGPFKRSKLSLGWAPPHPSFYMRR
                     ELYKDDGYFDLSYRIAADYDQMVRILKRDDIKVIYVPQVFVKMRLGGESTRIDNAISS
                     TKEIVEVMKNHNVNWKIAIIIRKISKLMQLFAHK"
     gene            14781..16151
                     /gene="manB"
     CDS             14781..16151
                     /gene="manB"
                     /note="O125_14"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ01606.1"
                     /translation="MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLG
                     GDARLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM
                     DYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
                     GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIP
                     NPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE
                     KNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHY
                     FRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINR
                     VEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDVPLMEEKTKLI
                     LELLNK"
     gene            16314..17720
                     /gene="gnd"
     CDS             16314..17720
                     /gene="gnd"
                     /note="O125_15"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ01607.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGKYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKEQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            17969..19135
                     /gene="ugd"
     CDS             17969..19135
                     /gene="ugd"
                     /note="O125_16"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ01608.1"
                     /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISP
                     IVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIK
                     DVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDTFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD"
     gene            19225..20259
                     /gene="wzz"
     CDS             19225..20259
                     /gene="wzz"
                     /note="O125_17"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ01609.1"
                     /translation="MAIIAKLWRLKNISSVRVMMRVENNNVSGQNHDPEQIDLIDLLV
                     QLWRGKMTIIISVIVAIALAIGYLVVAKEKWTSTAIVTQPDVGQIAGYNNAINVIYGS
                     AAPKVSDIQASLIGRYSTAFSALAETLDNQEEAEKLTIEPTVKNQSLPLAVSYVGKTP
                     EGAQKQLAKYIQQVDDQVNEELEQDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQ
                     IQEALQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQT
                     RQNLLDIENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLG
                     RNALRNYNAK"
     gene            complement(20445..21056)
                     /gene="hisI"
     CDS             complement(20445..21056)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAQ01610.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWAKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGNTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ"
BASE COUNT     6461 a   3848 c   4598 g   6478 t
ORIGIN
        1 ttacgccatc ttacgccagg gatttcataa ccagattatc ggtgccaaca tcaccaattg
       61 taagttcagc gacttacggg gcgacgccat cgaatggaac gtggcgatta acgacagtga
      121 tattttgata tctgaccatg tcatcgagcg cattaactgt accaacggca aaatcaactg
      181 gggcatcggc ataggccttg cgggaagtac ctacgataat aattatccgg aaaaccaggc
      241 agtgaaaaac tttgtcgtgg cgaatatcac gggatcggat tgtcggcaac tgatccatgt
      301 tgaaaatggt aaacattttg ttattcgtaa tatcaaagcc cgcaatatca cgccaaattt
      361 cagcaagaaa gcaggcattg ataacgcgac agtcgctatt tacggttgtg acaatttcgg
      421 gattgataat attgaaatga ttaatagcgc cgggatgtta atcggttatg gggtaattaa
      481 aggcaaatat ctctcgatac cgcagaattt ccgggtgaat aatattcaac tggataacac
      541 ccaccttgct tataaattgc gcggcatcca aatctctgcc gggaatgctg tctcctttgt
      601 ggcgctgact aacattgaga tgaagcgtgc gtcgctggag ttacacaaca aaccgcaaca
      661 tctttttatg cgaaatatca aggtgatgca ggaatcctca gttggagccg cattgagtat
      721 gaactttgac atgcgcaaag acgttcgagg cgtttttatg gcgaaaaaag aaacactgtt
      781 gtctcttgca aatgttcatg cggtgaatga aaaaggacaa agctctgtcg atatcgacag
      841 gattaatcac catattgtta atgtggaaaa gattaacttt agattgccgg aacggaggga
      901 atagatttgc gaccattcat aaacttactg gatataatgt tctaaaagat tataatcctc
      961 acactaactg ttaaagctgg ggctgggcag cattgactac tcagggaagg tactcatctt
     1021 tatcttgtgt ttcttacgta acaaccagac taaagtgatt tatgaacgat aatgttttgc
     1081 tcataggagc ttccggattc gtaggaaccc gactacttga aacggcaatt gctgacttta
     1141 atatcaagaa cctggacaaa cagcagagcc acttttatcc agaaatcaca cagattggcg
     1201 atgttcgtga tcaacaggca ctcgaccagg cgttagccgg ttttgacact gttgtgctac
     1261 tggcagcgga acaccgcgat gacgtcagcc ctacttctct ctattatgat gtcaatgttc
     1321 agggtacccg caatgtgctg gcggccatgg aaaaaaatgg cgttaaaaat atcatcttta
     1381 ccagttccgt tgctgtttat ggtttgaaca aacacaaccc tgacgaaaac catccgcacg
     1441 accctttcaa ccactacggc aaaagtaagt ggcaggcaga ggaagtgctg cgtgaatggt
     1501 ataacaaagc accaacagaa cgttcattaa ccatcatccg tcctaccgtt atcttcggtg
     1561 aacgcaaccg cggtaacgtc tataacttgc tgaaacagat cgctggcggc aagtttatga
     1621 tggtgggcgc agggactaac tataagtcca tggcttatgt tggaaacatt gttgagttta
     1681 tcaagtacaa actgaagaat gttgccgcag gttatgaggt ttataactac gttgataagc
     1741 cagacctgaa catgaaccag ttggttgctg aagttgaaca aagcctgaac aaaaagatcc
     1801 cttctatgca cttgccttac ccactaggaa tgctgggtgg atattgcttt gatatcctga
     1861 gcaaaattac gggcaaaaaa tacgctgtca gctctgtgcg cgtgaaaaaa ttctgcgcaa
     1921 caacacagtt tgacgcaacg aaagtgcatt cttcaggttt tgtggcaccg tatacgctgt
     1981 cgcaaggtct ggatcgaact ctgcagtatg aattcgttca tgccaaaaaa gacgacataa
     2041 cgtttgtttc tgagtaatgc agacgagtca gagaaaaaag gaccaggttg gactacgatt
     2101 gttcggaaag aggtactgat taaattatca gtatgtggat ttccgagtaa tccgagtaac
     2161 ccagatgctg atggtgtgta gtgttatcgt aaggtttaat caaagttatg cggaactaag
     2221 ctttggtata tagccatacc gtttggctaa cctatggcat aatttacgca ctatcagcca
     2281 cttagaggta ggaaaatgat gacgaattta aaagcagtta taccggtagc gggtcttggg
     2341 atgcatatgt tgcctgccac taaggcgatt cccaaagaga tgctaccgat cgtcgacaag
     2401 ccaatgattc agtacattgt tgacgagatt gtggctgcag ggatcaaaga aatcctcctg
     2461 gtaactcacg cgtccaagaa cgcggtcgaa aaccacttcg acacctctta tgaattagaa
     2521 tctctccttg agcagcgcgt gaagcgtcaa ctactggcgg aagtgcaatc tatctgcccg
     2581 ccgggcgtga ctattatgaa cgtgcgtcag ggcgaacctt taggtttagg tcattccatt
     2641 ttgtgtgcac gacccgccat tggtgacaat ccatttgtcg tggtgctgcc agacgttgtg
     2701 atcgacgacg ccagcgccga cccgctacgc tacaaccttg ctgccatgat tgcacgcttc
     2761 aatgaaacgg gccgtagcca ggtgctggca aaacgtatgc cgggtgacct ctctgaatac
     2821 tccgtcatcc agaccaaaga accgctggat cgcgaaggta aagtcagccg cattgttgaa
     2881 tttatcgaaa aaccggatca gccgcagacg ctggactcag acatcatggc cgtgggccgt
     2941 tatgtgcttt ctgccgatat ttggccggaa ctggaacgca ctcagccagg tgcatgggga
     3001 cgtatccaac tgactgatgc tattgccgaa ctggcgaaaa aacagtctgt tgatgccatg
     3061 ctgatgaccg gtgacagcta cgactgcggt aaaaaaatgg gttatatgca agcgtttgtg
     3121 aagtatggac tgcgtaacct aaaagaaggg gcgaagttcc gtaaagggat tgagaagctg
     3181 ttaagggaat aatgaaaatc gaatcggatg caacagatgc gaaaagactg taatagttgt
     3241 gaagattagc aggcaaagta acttgttgcg agtcttcctg ctattattga tttataaata
     3301 ttcgggataa taacaagtca gcaataggac tttttttaca catttccttg ttttcagggc
     3361 tgattagtaa gataatttag cttttggttt tttgtttatt gcgggcatga aacgctcgtt
     3421 acattgtaga catacacgca gtgctctggt agctgtatag ccaggggcgg tagcgtggtt
     3481 tatatttatg gtataattaa atatgagttt tgttatcata acctacttaa tatgttaggt
     3541 gaactgtgaa agtatataat gtctttattc ttaatggcct ttctgtattt gtcaaaatgg
     3601 caactctact tggacttaat aaagtattcg caatatattt aggtacgtct ggatatgcac
     3661 ttattggcca aatccaaaat atccttaata tagctatggt tgcgccatca caagctattt
     3721 caacgagtat tgttaagtat acgtcagagt ataagaatag taataaggaa aaaatctgga
     3781 gtttttggat taatgcaatt tatttgtcta ctataatggg atttataacc gctgttatca
     3841 taattatctt taaaaatata attatcgaac aatttttcaa ttctaatgat aaagtaagca
     3901 tcgcaattta tttcttggga gggagtgtta ttttatatgc atggaataat ataattcttt
     3961 ctatgttaaa tggattgtca tttattaaaa attatatatg gattaatatc atatcgagtt
     4021 taatatctgc aatatacgcc tttatattga caatctcttt tggtatgaga ggagcattga
     4081 ttgctgtagt ttcaaatcaa gctatattgt tttttgtgac ttttttttac tcaaaaaaat
     4141 atttaagaga atactatgtt aataattgca atcgaattga tatttcaata ttaaaacgga
     4201 tcataatttt ttctttaatg acagtcactt cagctatatt agtgccagtt agtacgttat
     4261 atgtgagaaa tgaaatcata acatcaataa atattgagta tgctgggttg tgggatgctg
     4321 ttaatagaat aagttcagtc tatttgatgt taattacgac tacattgggg atatatttct
     4381 ttccaaggtt ttcaagtgca tctaaccgtt cagaattgct taatgaaata aaagtttgtt
     4441 atttgtattt ggttccgtta gtttgtatat cttcagtctt gatgtataca tttcgcggtt
     4501 tgatagtaaa tattctattt acacacgagt tcgttcctat tgttgatgtt atagtttatc
     4561 aactaattgg agattttttt aagataattg catgggtgct tggttatttg ctgattagca
     4621 aagcattcgt aaaagaatat atagtgttag aagtgttaca atggtctgta tattgtatat
     4681 taagtaaata ttcgttatgc tacgtcgaaa atgctcaaat ttcttatgtt tttaaagcgt
     4741 atataatatc tcaagcatta tatatgttct ccttaatagt aacgatctgt tatctgctta
     4801 ataaaaacaa agtatgatat attatgatta ataaaaacaa agtatccgtt ataataccgg
     4861 tatataatgc tgaaaaatac ttaggcgcat gcattgacag tatattggaa caaacatata
     4921 aaatatttga aattatcatc atcaatgatg gctcgcagga tggtacacaa aagatacttg
     4981 atgaatataa aaataaatat ccctcgatat tcaaaattaa gcatagagaa aataaaggga
     5041 tagtagctac tttaaatgaa ttattagaca tggctacggg agtgtatatt gctagaatgg
     5101 atgctgatga tattgctcac agagaaaggt tgagattaca agttgaaata atggatgcag
     5161 atcaaaaaat agcgtgttgt ggaactaata tcaaagtttt tgagtcagct gttaatagcg
     5221 gaaaaattat aaaaatgcct aactcagacg aagcctgtaa aataggattg ttggtgggca
     5281 gttgttttgc tcatccaact gtaatgatga gaagcagcat tataaaaaaa gaatgcctat
     5341 attataagcc acgctaccaa tatgctgaag attatgagtt ttggagtaga ttagcaaact
     5401 acggaaaatt ctgtaatata aatataccct tgctttatta tcgaaatcac ggaaatcaaa
     5461 tatcgaatat aaaaaagcat atacaagcag atattcacat atctattgcc attgataatt
     5521 taaaaaaaca ggggattatt ctcgataaag atgagctagg gatggttttg tttccgcaat
     5581 caagtcatcg ttttcttaat gctatttgtt attattttaa ggtgtatttt attatttttt
     5641 ctaagttagg agtaaagatt aaatatataa attgtgtttt tcttagaaaa tttgcttatt
     5701 attgcaaaat aaagattaat tcaatcttaa aaaaaggata ttaatatgaa taacttttat
     5761 aaaattagtt tgataggcac aactcaaggt ggaagggata aagaaattga acgactgctg
     5821 aatagcgtag ctagcagtac gtacaaaaac ctagaaatta tatttattga tcagactgat
     5881 gatatcataa ttgagcaatt atttttaaaa cacgcaaaaa atataaaata caagttggtt
     5941 aaatcaaata aagtaccact ttcaactgct cgtaatcaag ggcttaaact atgcagtggt
     6001 aatgttattg ggttctgtga tgatgatgct ttttatgctc ctgatttttt tgagaaggtg
     6061 attcaatcaa atatcaaaaa agaaaccgtt ctttcagttc ctgtattaga ttttcaaaca
     6121 atgaaatctt atgccaatag agtttatcct aaaactaaaa aggaaatggg ttataatcaa
     6181 ataattaaat cgtcactaag tgtgggtact tttattttta ctcataaact cgataatata
     6241 tattttgatg aaaggttagg tgttggtact ttattcggtg gatccgaaga aacggagtta
     6301 ttttttcggc tgaaatctct tgggtttaga gtatgttttc aacctatatt tggagtttat
     6361 cacgataatg atttatattg tgaagggata ccagaaaaat acagaaaata tgcagttgga
     6421 tatggtgtcg tgataaagaa gtatttagtg aaatctcgtt atttattact attggaaatt
     6481 ttcaggatca cagtaaaatc attttttggt atcgttttaa aaaaacaaaa aaaattatat
     6541 atgtacagat taatcggttt ctggacggga ttgttaaaat atgatttata aacaatacaa
     6601 actggtattg gctcaatttt atggctttat tgggttgata atgattgctg tattgagcac
     6661 ttctgtcaaa gttgaaattg atgctatcct aatttggttt ttatctgtaa tatttacaat
     6721 tgcaattatt ttttttgtat ataatcgaat gtgggtatgg tttgatggaa tgtttataat
     6781 attatcgcct ttttattttt ttgtgtcttt tttgttgtat tatttttttg gtgttaatgt
     6841 atttaatgtt gaaaataata taatcaacac ttcattctta tattgtgttg ctgtttggtg
     6901 tatagttgca tcgattagtt tgattaggcc tcacggtatc aatatatttc ttttaaacaa
     6961 acaatataac tatgacaata actataatct atttattcca tcatgcatag catggttaat
     7021 atcattattt tttctatatc aatcaagaaa tctttctctg aatgctttgg gcgaaagtac
     7081 tcgcctagag ttaattaatt cggtaagtca aagtggatgg tatctgaaat atgtggttat
     7141 tgcttatttt tggattttac ttgatttaaa ggtagtaaaa aaaaatctca caaattatag
     7201 tttcgtaata tacagcatac ctgtgctttt atatttttat actttaatgc tggtaggttc
     7261 aagacgagaa attgctttat cttttattat ggctgtattg ctatcacttt ataaagctaa
     7321 atttaagata ccattaaaag tagcgttgtt cagtattcta tttgtatcaa cgattatact
     7381 ttttgggata tatcgttcag attataatgt cgaatcaagc ataagattat tgaatgcttt
     7441 gggtgaattt atttatccta tatctacact tcaatattat tcttcgatac attatcagac
     7501 tcaatttttt ggtatatcct atcttcagtt cattgtaaac tttataccaa aagaattatt
     7561 tatgggatta aagccagaca cattagctat tcaatttgca aaggaagttt atttgccaag
     7621 tcaagagttt atgatgggat atgcatttac tccttttaca gaagctttta ttaattataa
     7681 ttattatggt gtaattatat ttcctgctat tttatgtggt tattcatata taatggaaag
     7741 gttaattggg aacaactatt ttctttatct tgtttttctt tcccaatcta tcaatttcca
     7801 acgctcagag ttttcttcta tgatatttga attaggtatg ttctttatgg catacatatg
     7861 cttgagatta tcgatgcaaa tagttttttt taaattcaaa taaggtgttt ttatgacaat
     7921 attagttacg ggtggagctg gatatattgg gtcccatact gttctgtcat tattggagca
     7981 gaatgaagac gttgtcatca tagataattt ttctaattct acagaagata tcatcaaagt
     8041 catttcaaag cttagtggta agaaaatcag agcatataag gtagatttac tggacaaaaa
     8101 agaattaaag actatattca cgaatcacac attctctaaa gtattacatt ttgcaggcct
     8161 taagtctgtc tcagaatcag ttcaaagtcc tatacggtat tatatgaata atattgttgg
     8221 gcttttaaat ttgttagagt taatgaagat ctttcatgta aataaaatta tctttagctc
     8281 atctgctacg gtgtacggtc ttccagaaac gatacctatc aatgaaaaat gtcgtatagg
     8341 tgaaacaacg aatccatacg ggaccagtaa atattactcc gaggttatat taaaagatgc
     8401 ttctctggca aaccctaaat tagatgtgat tattttgcga tattttaatc cagtgggggc
     8461 gcatgagtct gggttaatag gtgaaaatcc cagaggaact cctgctaact tagttccata
     8521 tatgatgaat gttgctttag gtaaattacc tgcgcttact atttatggtc atgactatcc
     8581 aacgcctgat gggactggta tcagagatta tattcatgta aatgatttag ctgaggggca
     8641 tatttcagca tttaaaatgt ttggcaaagg aggaaattat aaaatatata acttaggtac
     8701 gggtagagga tattctgtat tagaagtaat aaaaacattt caatcaatta ttgggaaaaa
     8761 tattaattat agttttggcc ctaaccgaag cggcgatgtt gcagaatgtt gggcggatgt
     8821 ttccaaagct gaaaaagaac tggactggaa ggctaggcga gatttgaccg aaatgctttc
     8881 ttctgcgtgg aaatggcata cgctaaatcc tgatggatac aattaaatat aaaaggtgcc
     8941 tatgttatat ttggatggta ttatatatag tctccagtca tacggtggca tttctgttta
     9001 ttataatcaa ataataaaag caataaaagc cacaaatatt gaatatacga tattaaacta
     9061 tgagaataca ggctgtcaat ttataagtga agatgtgcga caacctggac gttatattaa
     9121 tctatatcct cgctttcttg aaaggtatcg agctgttgat attcctgaaa actctctatt
     9181 acattctagt tattatagat ttaataaggg caaaaaaaat aaaaacataa caacagtaca
     9241 tgactttaca tatgaaaaat atatgtcagg tttacgtaaa tacgttcatt gtcatcagaa
     9301 gtacaatgct ataaaaaaca gtgataaaat aatttgcatt tcagaaaata ctgccaatga
     9361 tttgttgagg tattgtccag tacctgaaag taaaatcgaa atcattcaca atggggtgtc
     9421 tgataatttt tatgaattaa aaaacgttaa ttataacgat gatgataatt tcatgctttt
     9481 tattggttcg agaaaagcat ataaaaactt tcaacttgca gttgaagcaa taaacaaatt
     9541 agaggggttc aaactatata ttgtaggtgg aggccctttg ggaaaggctg agaaattttt
     9601 acttgataaa tatataccat atcgatatat tcattatcca tatttaactg agcaagagtt
     9661 gaatctaaaa tttaatcaag ctcattctct tatttatccg tcaagttatg aaggatttgg
     9721 tattcctctt ttagaagcaa tgagggcagg atgcccattc attgcgtata atcactcctc
     9781 aataccagag gttgcaggtg acgccggtta tttgatggat gagttaagta taagcaacct
     9841 tattgatggt atatcattta taaatagaaa tcgaaatcaa attattaaga aaggtttatc
     9901 tcaagcacaa cgtttttctt ggaaaaaatg tactgacaaa actatcgata tttacaagaa
     9961 actactgtag gaataatttt atgacaaaga aagcattaat tactggcatt actggtcaag
    10021 atggttcata tttggcagag tttctactaa ataaaggtta cgaggttcat ggaataaaac
    10081 gacgttcttc tatttttaat actggacgta ttgaccatat ataccaagat ccccataata
    10141 ttaatttaaa attacacctt cattatggtg acttaacaga tacttctaat ttgactcgta
    10201 tattatctga agttcaacct gatgaagttt acaacctcgg agcaatgagt cacgtagctg
    10261 tttccttcga atccccagaa tatacagctg atgttgatgc tataggtact ttacgattat
    10321 tggaagctat tcgttttttg ggattagaaa aaaaaacccg attttatcag gcgtcaacct
    10381 ctgaattgta tggattagtt caggaagttc cacaaaaaga gacaacgccg ttctatcctc
    10441 gttcacctta tgccgtagct aaactgtatg catattggat cactgtaaac tatcgtgagt
    10501 cttatggaat gtatgcatgc aacggtattt tgttcaatca tgaatcccca cgtcgtgggg
    10561 aaacgtttgt aacacgtaaa atcacacgtg ctatagctaa tatttcgcag ggaatagaaa
    10621 aatgcttata tcttggcaac atggattctt tacgtgattg ggggcatgcg aaagattatg
    10681 ttcgtatgca atggatgatg cttcaacaag accagccaga agactttgtt attgccaccg
    10741 gcaaacaaat atctgtacgt gaatttgtcc gtatgtctgc taaagaagtt ggacttgaac
    10801 ttgagttttc cggtactggt gttgatgaga ttgcaatggt tgtaaataaa acatcagatt
    10861 gcgccgttgg tgttaatatt ggtgatgtta ttgttcgcgt tgaccctcgt tattttcgac
    10921 cagcagaagt tgaaactctt cttggtgatc caacaaaagc aaaaaatgtc ttgggttggg
    10981 agccagagat tacagttgaa gaaatgtgtg cagaaatggt ggctagtgat ttagaaaaag
    11041 ctaaacagca tgcacttctt aaaagccatg gttttgacgt ggcagtctct ttggagcgtt
    11101 aaagtatgac caagaagcga atttttgtgg ctggacatcg tgggatggtt ggttctgcta
    11161 tttgtcgtca attattagca cgtaatgatg ttgagttaat tgtcaaaact cacaaagaac
    11221 tcgatttgac agttcaaaag gatgttgaat gtttttttga gcaagagaga atagatcagg
    11281 tttaccttgc agcagcaaaa gtaggaggaa ttcatgctaa taacactttt ccagctgaat
    11341 ttatttatca gaaccttctc attgaaagca atattattca ctcatcttat aaagcgggca
    11401 taaagaaact attattctta gggtcaagtt gtatctatcc aaagtttgca gaacagccaa
    11461 tgaaagaatc tgcacttttg acgggaactc ttgagcctac taatgagcct tatgctattt
    11521 ccaaaatagc aggtataaag ctatgtgaat cttataatcg ccaatatgga tgtgattatc
    11581 gcagtgtaat gcctactaac ttatatggta tgaatgataa ttttcatccc aataactcac
    11641 atgtaattcc agcgcttatg cggcgttttc atgaagcaaa ggaacttggt ttaaatgaag
    11701 tggttgtctg gggaacggga actccaaaac gcgagttttt atatgttgat gatatggcag
    11761 ctgcatcagt atatgtgatg gagcttgatg atgaaattta taaaaaaaat actcaaccaa
    11821 tgttatctca tattaacgta ggtactggtg ttgattgttc catacgtgaa atggcagaaa
    11881 caatggcttt agttgttggc tatgatggaa aaattgtttt tgatataaca aaaccagatg
    11941 gttcgcctcg taaacttatg gatgttacac gccttgagaa tttgggctgg aaatatcgtt
    12001 ataatttaaa acaaggacta gaattaacat ataaatggtt tataaataat cttgactcat
    12061 ttaggagtta atattgaaca agagattaga aacagagtta tttaaatcaa tagttgaaca
    12121 tactccacta atctcgatag accttattat aagaaacgaa gatggtaagg cgctgcttgg
    12181 tcagcgcctt aatcgtccag cacaaaatta ttggtttgtg ccggggggac ggattcttaa
    12241 agatgagtct ttcgagaacg cattcaaaag agttactttt gaagaattgg gtgttcaaat
    12301 tagcattaat gaagcaaaat ttcttgggat ttatgaacat ttctacagcg acaatttttc
    12361 tgggacttgt ttttcaactc attatgtcgt acacggatat gagattagtt tgatgccaca
    12421 tcaaattaac tatccaacac tacaacatag tacttacaat tggttcgata tagccgaatt
    12481 gttagctaat tcctcagttc atcagtacac aaaaaattat tttaagtgaa ggttatttat
    12541 atgctacttc ctgttgtaat ggccggtggt tctggaacta gattgtggcc actttctcga
    12601 acactatatc cgaagcaatt cctgtcgtta actagtcgtt tgactatgct acaagagacc
    12661 ttaagaaggc ttgaaggggt tgaacatcgt cctgctctgg ttatttgtaa tgaagttcat
    12721 cgttttatcg ttgcagaaca gatgcgtaat gtaaatttag cgaatagtgg cattttacta
    12781 gagccgatag gtcgtaatac tgcccccgca gttgcgcttg ctgctcttaa agcgatttca
    12841 tcaggtgagg atccaatact gcttgtacta gcagccgatc atgaaataca agaccaaaag
    12901 cgctttatat cgtcaatatt ggctgcaaaa gaatttgcag aggaaggtaa gctggtaact
    12961 tttggtattg tgccaaccaa accagaaact ggatatggct atataaaaac cggagaaaat
    13021 ttaaatgaat atggttttaa agtttctgct tttgttgaaa agcctgagct agatgtggcc
    13081 aaaaaatatc ttgaagatgg agattatctt tggaatagtg gaatattcat gtttagggct
    13141 tctgtgttta ttgatgagtt gaataaattt agaccagaca tactaaaaat atgccaacaa
    13201 gcattgaagt tctctacaca agatcttgat tttatccgta tagataatga ctcatttagt
    13261 tgttgccctg aagaatccat tgattacgct gttatggaga aaacaacaga ggctgtggta
    13321 gttccattaa atgcccactg gagcgatgtt ggttcttggt ctgcattatg ggaaattagc
    13381 agaaaagata aaagtggaaa tgcaattaga ggagatgtat taattcatga ttcttctgac
    13441 agttatcttt actcacaaca tagattaatt ggtgtagtag gagttaaaga tttagtagtt
    13501 gttgaaacta aagatgctat tctcgttgcg cataaagata aagttcaaca ggtaaaaaat
    13561 attgtagaaa aacttaaagt taataaccgt acggaatatc tgcagcatcg tgaaatattt
    13621 aggccatggg gcagtcatga ctctatagcg gaaggatctc gatttgaggt taaacatgtc
    13681 gttattcatc ctggacataa aactgctaaa cagattcatt accatcgtac tgagcattgg
    13741 attgttgttt ctggaacagc aaaagtccat tatgaagatg aaatatttct tgtttctgaa
    13801 aatgaatcaa cttatatacc aataggtgta cctcatttta ttgagaatcc aggaaagatc
    13861 cctttggaga ttattgaggt acgttcaggt gtttacttgg atgaagatga tgttgttaga
    13921 atctaaaatg atgctggata ctaatgcaac attattattc gtaatgcggt actgacgtta
    13981 tttaattatg attattattg gatgttaaaa tgaaagtcag tattattaca gtgacttata
    14041 atagtgaaaa gactttaagg gatactttag agtcaataga gttgcaaacc tataaagata
    14101 tagagtatat aattattgat ggtggttcta cagataatac gttaaaacta attaacgaag
    14161 tatcaacaag agtaaccaaa tgtctatcag aaagcgataa cggtatctat gatgctttaa
    14221 ataaaggtat aaatttatct acgggagata ttattggatt cgttcattct gatgaccttt
    14281 tagcaagacc tgatattatt gaaactattg taagtcgttt ccatgagaca aaagcggatg
    14341 ttgtatacgg tgatttggtt tttttcgaaa aaaaccaaat tgatataatc aaacgatact
    14401 ggcgtagtgg tccttttaaa cgttctaagc tatcattagg ctgggcacca ccgcatccat
    14461 ctttctatat gaggagggaa ttatataaag acgatggata ttttgattta tcctatagga
    14521 ttgctgcaga ctatgatcag atggtcagga ttttgaaacg tgatgatatt aaagttattt
    14581 atgttcctca agtatttgta aagatgagat tgggtgggga aagtaccaga attgataacg
    14641 cgatatcaag tacaaaggaa attgtagaag ttatgaaaaa ccataatgta aattggaaaa
    14701 ttgctatcat tatcagaaaa atctcaaaac taatgcaatt atttgcgcat aaataatttt
    14761 attattggta aggtttttat atgaaaaaat taacctgctt taaagcctat gatattcgtg
    14821 ggaaattagg cgaagaactg aatgaagata ttgcgtggcg cattggtcgc gcctatggcg
    14881 aatttctcaa accgaaaacc attgtgttag gcggtgatgc ccgcctcacc agcgaaacct
    14941 taaaactggc gctggcgaaa ggtttacagg atgcgggcgt cgacgtgctg gatattggta
    15001 tgtccggcac cgaagaaatc tatttcgcca cgttccatct cggcgtggat ggcggcattg
    15061 aagttaccgc cagccataac ccgatggatt acaacggcat gaagctggtg cgcgaagggg
    15121 cccgcccgat cagcggcgat accggactgc gcgatgtcca gcgtctggca gaagccaacg
    15181 actttcctcc cgttgatgaa accaaacgcg gtcgctatca gcaaatcaat ctgcgtgacg
    15241 cttacgttga tcacctgttc ggttatatca acgtcaaaaa cctcacgccg ctcaagctgg
    15301 tgattaattc cgggaacggc gcggcgggtc cggtggtgga cgccatcgaa gcccgcttta
    15361 aagccctcgg cgcaccggtg gaattaatca aagtgcacaa cacgccggac ggcaatttcc
    15421 ccaacggtat tcctaacccg ctactgccgg aatgtcgcga cgacactcgc aatgcggtca
    15481 ttaaacacgg cgcggatatg ggcattgctt ttgatggcga ttttgaccgc tgtttcctgt
    15541 ttgacgaaaa agggcagttt atcgagggct actacattgt cggtttgctg gcagaagcgt
    15601 tcctcgaaaa aaatcccggc gcgaagatca tccacgatcc acgtctctcc tggaacaccg
    15661 ttgatgtggt gactgccgca ggcggcaccc cggtaatgtc gaaaaccgga cacgccttta
    15721 ttaaagaacg tatgcgcaag gaagacgcta tctacggtgg cgaaatgagc gcccaccatt
    15781 acttccgtga tttcgcttac tgcgacagcg gcatgatccc gtggctgctg gtcgccgaac
    15841 tggtgtgcct gaaaggaaaa acgctgggcg aactggtgcg cgaccgtatg gcggcttttc
    15901 cggcaagcgg tgagatcaac agcaaactgg cacaacctgt tgaggcgatt aaccgcgtgg
    15961 aacagcactt tagccgcgag gcgctggcgg tggatcgtac cgatggcatc agcatgacct
    16021 ttgccgactg gcgctttaac ctgcgctcct ccaacaccga accggtggtg cgcctgaatg
    16081 tggaatcgcg cggtgatgtg ccgctgatgg aagaaaagac aaaacttatc cttgagttac
    16141 tgaataagta attgagtaaa ttcatataaa taggttttaa aagacggaaa agatgagata
    16201 ttcagtgtgg tatcgcaaag gtaatgctat tcaccatctc tatgagtgag ttaacatcta
    16261 taccacattt aagccgcaca ctcggcggtg accacccctg acaggagtaa acaatgtcaa
    16321 agcaacagat cggcgtcgtc ggtatggcag tgatggggcg caaccttgcg ctcaacatcg
    16381 aaagccgtgg ttataccgtc tctattttca accgttcccg tgaaaagacg gaagaagtga
    16441 ttgccgaaaa tccaggcaag aaactggttc cttactatac ggtgaaagag tttgttgaat
    16501 ctctggaaac gcctcgtcgc atcctgttaa tggtgaaagc aggtgcaggc acggatgctg
    16561 ctattgattc cctcaaacca tacctcgata aaggtgacat catcattgat ggtggtaaca
    16621 ccttcttcca ggacaccatt cgtcgtaacc gtgagctttc tgcagaaggc tttaacttta
    16681 tcggtaccgg tgtttccggt ggtgaggagg gcgcactaaa aggtccttcc attatgcctg
    16741 gtggccagaa agaagcctat gaactggttg cgccgatcct gaccaaaatc gccgcagtgg
    16801 ctgaagacgg ggagccatgc gttacctata ttggtgccga tggcgcaggt cactatgtga
    16861 agatggttca caacggtatt gaatacggtg atatgcaact gattgctgaa gcctattctc
    16921 tcctgaaagg cggcctgaat ctctctaacg aagaactggc acagaccttt accgagtgga
    16981 ataacggtga actgagcagc tacctgatcg acatcactaa agacatcttc accaaaaaag
    17041 atgaagacgg taaatacctg gttgatgtga tcctggatga agcagcaaac aaaggtacgg
    17101 gtaaatggac cagccagagt gcgcttgatc tcggagaacc gctgtcgctc attaccgagt
    17161 ctgtgtttgc acgatacatc tcttctctga aagagcagcg cgttgcggcg tccaaagtac
    17221 tgtctggtcc gcaagcacag ccagcaggcg acaaggctga gttcatcgaa aaagttcgcc
    17281 gtgcgctgta tcttggcaaa atcgtttctt acgctcaggg cttctctcag ctgcgtgctg
    17341 cgtctgaaga gtacaactgg gatctgaact acggcgaaat cgcgaagatt ttccgtgctg
    17401 gctgcatcat ccgtgcgcag ttcctgcaga aaatcaccga tgcttatgcc gaaaatccgc
    17461 agatcgctaa cctgctgctg gctccgtact tcaagcaaat tgccgatgac taccagcagg
    17521 cgctgcgtga tgtcgttgct tatgcagtac agaacggtat tccggttccg accttctccg
    17581 cagcggttgc ctattacgac agctaccgtg ctgctgttct gcctgcgaac ctgatccagg
    17641 cacagcgtga ctattttggt gcgcatactt ataagcgtat tgataaagaa ggtgtgttcc
    17701 ataccgaatg gctggattaa tctgatttaa ccaacaataa aattgaggcc cggcgtatat
    17761 tgcaccgggc ttttttttgc caaatatctt atagactaaa tttcactgct taatattaac
    17821 ttaataaata tcagctattc ttataaagaa aatctgaatt gtttttcgtt gcgttgacca
    17881 tctgacaagg tagcgttaaa acttttagct cttatcaaga tgctaaaaac atcatgattc
    17941 acagttaagt taattctgag agcatgaaat gaaaatcacc atttccggta ctggctatgt
    18001 aggcttatca aacgggcttc taatcgcaca aaatcatgag gttgtggcat tagatatttt
    18061 accatcacgc gttgctatgt tgaatgatcg gatatctcct attgtcgata aggaaattca
    18121 gcagtttttg caatcagata aaatacactt taatgccaca ttagataaaa atgaagccta
    18181 ccgggatgct gattatgtca tcatcgccac tccaaccgac tatgatccta aaactaatta
    18241 tttcaataca tccagtgtag aatcagtaat taaagacgta gttgagataa acccttatgc
    18301 ggttatggtc atcaaatcaa cggttcccgt tggttttacc gcagcgatgc ataaaaaata
    18361 tcgtactgaa aatattatat tctccccgga atttctccgt gagggtaaag ccctttacga
    18421 taaccttcat ccgtcacgta ttgtcatcgg tgagcgttcg gaacgcgcag aacgttttgc
    18481 ggcgttatta caggaaggcg cgattaagca aaatatcccg accctgttca ccgattcaac
    18541 cgaagcagaa gcgattaaac ttttcgctaa tacctatctg gcgatgcgcg tagcatactt
    18601 taatgaactg gatagctatg cagaaagttt aggtctgaat actcgtcaga ttatcgaagg
    18661 tgtttgtctc gatccgcgta ttggcaacca ttacaacaat ccgtcgtttg gctatggtgg
    18721 ttattgtcta ccgaaagata ccaagcagtt actggcgaac taccagtctg tgccgaataa
    18781 cctgatttcg gcaattgtcg atgctaaccg cacgcgtaaa gactttattg ccgatgccat
    18841 tttgtcacgc aaaccgcaag tggtgggtat ttatcgtctg attatgaaga gcgggtcaga
    18901 taacttccgt gcgtcttcca ttcaggggat tatgaaacgt atcaaggcga aaggcgttga
    18961 agtgatcata tacgagccgg tgatgaaaga agatacattc ttcaactctc gtctggaacg
    19021 tgatctcgcc accttcaaac aacaagccga cgtcattatt tccaaccgta tggcagaaga
    19081 gcttaaggat gtggcagata aagtctacac ccgcgatctc tttggtagcg actaacatcc
    19141 tgttatcagg gcgattttcg ccctgattgt cttatgttcc ctttgtaata attcattatt
    19201 tttatcattt atcctatagc attcatggcg attatcgcta aactatggcg acttaaaaat
    19261 atttcgtccg ttagggtaat gatgagagta gaaaataata atgtttctgg gcaaaaccat
    19321 gatccggaac agattgattt gattgattta ctggtccaac tatggcgtgg caagatgaca
    19381 attatcatct ctgtcattgt ggctattgcc ctggctatag ggtatctggt cgttgccaaa
    19441 gaaaagtgga cttcaacagc tatcgttact caacctgatg tggggcaaat cgctggttat
    19501 aacaatgcca taaatgtgat ttatggttcg gcagcgccga aagtctccga cattcaggct
    19561 tcacttatcg gacgttacag cactgcattt tcagcattag cggaaacgct ggataaccag
    19621 gaagaagcag aaaagctgac cattgagcct accgttaaaa atcagtcatt acctttagcg
    19681 gtgtcttatg ttggtaaaac acctgaaggt gcgcagaaac agctggcgaa gtatatccag
    19741 caagttgacg accaggtaaa tgaagaactg gaacaagacc tgaaagacaa catcgcgctg
    19801 cgaatgaaaa acttgcagga ttctctgaag acgcaggaag tggtcgctca agaacagaaa
    19861 gatctgcgta tccgtcagat tcaggaagcg ttgcagtatg cgaatcaggc gcaggtgaca
    19921 aagccacagg ttcagcagac tgaagatgtg acgcaagata cgttgttcct tttggggagc
    19981 gaagcgctgg agtcgatgat taagcacgag gcgactcgtc cgttggtgtt ctcaccaaac
    20041 tactatcaga ctcgtcaaaa cctgctggat attgaaaact taaaggttga tgatcttgat
    20101 attcatgctt accgctatgt aatgaaaccg acgttaccta ttcgtcgcga tagcccgaag
    20161 aaagcaatta ccttgattct ggctgtgctg ctgggcggca tggttggcgc ggggattgtg
    20221 cttgggcgta acgcgctgcg taattacaac gcgaaataat attattgtgc atttaagaga
    20281 aacgggcagg gtggtgacac catgcccgtt ttttttgccg gatgcgatgc tggcgcatct
    20341 tatccggcct acgtgtgttg agataatgtg taggcacgat aagcttgcgc atcgggcaat
    20401 ggctccgggt gtgacaacaa catcacacct gctcagcccg caactcactg atgccgttta
    20461 cgcaggttct caattaccgt cgttaaatcc agatcctgat cctgcaacag caccagcagg
    20521 tgatacatca aatccgatgc ctcgttggtc agctcaaagc ggtcatgtac cgttgcggca
    20581 agtgcggttt ccacgccttc ttcgcccact ttctgcgcaa tgcgtttggt gccgctggca
    20641 tacagtttgg cggtgtagga ggtttccggg tcggcagatt tgcgctcggc gagcagttgt
    20701 tccagttgat acaggaacag ccactggtga gcggtgttgc cgaagcagct gctggtgcct
    20761 ttgtggcagg tcgggccgat gggattcgcc agcactaata aagtgtcgtt gtcgcagtcc
    20821 ggcgcaatac tcactacgtt gaggaaattg cccgacgttt cgcctttggc ccacagtcgc
    20881 tgtttagtgc gcgagaagaa ggtgactttg ccgctttcga tggttttgtc taaggcttcc
    20941 gggttcatat agcccagcat taacacttca ccggataccg cgtgttgcac aatcaccggc
    21001 atcagtccgt cggttttttc ccagtccagt tcgcggcgtt gttgttctgt taacatatcc
    21061 tgatctccac gccctgtgtt gccaggtacg cttttaattc accaatattg attatttgtt
    21121 tgtggaatac ggaagctgcc agcgcgccgt caacgtcggc atcgcggaag gcttcgagga
    21181 agtgttccat ggtgcccgcg ccaccggagg caatcagcgg gacgtggcaa acttcacgca
    21241 cttttttcag ttgttcgagg tcgtaaccgt tacgaacacc atcctgattc atcatgttga
    21301 ggacgatttc tccggcccca cgtttttgca cttcctgtac ccagtcgact gtttcccact
    21361 gagtgacgcg ggtgcggctt tcatc
//
