LOCUS       AY217096               19013 bp    DNA     linear   BCT 30-OCT-2003
DEFINITION  Escherichia coli O128:B12 O-antigen gene cluster, complete
            sequence.
ACCESSION   AY217096
VERSION     AY217096.1  GI:37788079
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 19013)
  AUTHORS   Shao,J., Li,M., Jia,Q., Lu,Y. and Wang,P.G.
  TITLE     Sequence of Escherichia coli O128 antigen biosynthesis cluster and
            functional identification of an alpha-1,2-fucosyltransferase
  JOURNAL   FEBS Lett. 553 (1-2), 99-103 (2003)
   PUBMED   14550554
REFERENCE   2  (bases 1 to 19013)
  AUTHORS   Shao,J., Lu,Y. and Wang,P.G.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JAN-2003) Chemistry, Wayne State University, 5101
            Cass Ave., Detroit, MI 48202-3929, USA
FEATURES             Location/Qualifiers
     source          1..19013
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /serotype="O128:B12"
                     /db_xref="taxon:562"
     gene            630..1751
                     /gene="wbsH"
     CDS             630..1751
                     /gene="wbsH"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AAO37690.1"
                     /db_xref="GI:37788080"
                     /translation="MIKILHIHLSSKISGAQRVSLDEMKTLSNHYSQYMVCSKEGDFT
                     QEADRIGVKTYVIETLVREISPLKDFYSLIKLYKFIKQEKFDIIHTHSSKSGFLGRLA
                     AKLAGTKQIIHTVHGFAFPSTSNRVVKLIYFLMEYFASLCSSVIIVMNENDEKIARKY
                     FSSAPWTKVTLLNNAVDIKKFQKRYIGIESKSEINEQKKFKMVMIGRLCEQKNPLLII
                     NALKILGDHYYVDFVGDGPLRSDLESQIAKRGLEKRVRLLGWCSSVEEIIFKYDLFLL
                     PSKWEGMPLAILEAMASKVPVLCSNIDANAYLINKTSGFLFNNDDAKDLAKNIKYIFD
                     NVDVRRKVAEDAYLAVVKDFELSERTKILESIYTNNYFL"
     gene            1764..2888
                     /gene="gmd"
     CDS             1764..2888
                     /gene="gmd"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="AAO37691.1"
                     /db_xref="GI:37788081"
                     /translation="MDKNKIALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTE
                     RVDHIYQDPHTCNPKFHLHYGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPE
                     YTADVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYA
                     VAKLYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCL
                     YLGNMDSLRDWGHAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAEQVGIKL
                     RFEGVGVNEKGIVVSVTGKDAPAVKSGDIIVKVDPRYFRPAEVETLLGDPTKAHEKLG
                     WKPEITLREMVSEMVANDLEAAKKHSLLKSHGFNVSLSQE"
     gene            2892..3857
                     /gene="fcl"
     CDS             2892..3857
                     /gene="fcl"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-fucose synthetase"
                     /protein_id="AAO37692.1"
                     /db_xref="GI:37788082"
                     /translation="MFLQRIFIAGHRGMVGSAIRRQLEQRGDVELVLRTRDELNLLDS
                     RAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKL
                     LFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRS
                     VMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMA
                     AASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASK
                     PDGTPRKLLDVTRLHQLGWYHEISLEAGLASTYQWFLENQDRFRG"
     gene            3857..4360
                     /gene="gmm"
     CDS             3857..4360
                     /gene="gmm"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosyl hydrolase"
                     /protein_id="AAO37693.1"
                     /db_xref="GI:37788083"
                     /translation="MMFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQG
                     YWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTH
                     YVVLGFRFRVAEEELLLPDEQHDDYRWLTPDALLASENVHANSRVYFNNDPRAIIGLN
                     KKEVKNV"
     gene            4353..5801
                     /gene="manC"
     CDS             4353..5801
                     /gene="manC"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose pyrophosphorylase"
                     /protein_id="AAO37694.1"
                     /db_xref="GI:37788084"
                     /translation="MSDVPLIAVVMAGGTGSRLWPLSREHYPKQFLQLSGESSLLQST
                     LLRLSTLSCETPLVITNEQHRFVVAEQLRQIDQLRDNIILEPCGRNTAPAIALSAFTA
                     LKRNEQQDPILLILAADHIISKADVFCDAIQKSKTVAEQGNIVTFGIIPEYAETGYGY
                     IKKGDPFKILPNITHDKFYHVQQFIEKPNHSTAEEYVSTGEYLWNSGMFMFKASVYLE
                     ELKKHRPDIYEICEQTASLSYNDLDFIRLPKHIFQDCPSESIDFAVMEKTKNCIVRPV
                     DIGWSDVGSWHSLWDISDKTQDGDVCKGDILTYNTKNNYIYSESALVAAVGVEDIVIV
                     QTKDAILVSKKTEVQDVKKIVEMLKEQERSEYISHREEFRPWGKFDAIDQGERYKVKK
                     IVVKPGEGVSLRMHHHRSEHWIVLSGTAKVTLNDKTVLLAANESIYIPLGATYSLENP
                     GIIPLNLIEVSSGDYLGEDDIVRQKERYRIDD"
     gene            5805..7184
                     /gene="manB"
     CDS             5805..7184
                     /gene="manB"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="AAO37695.1"
                     /db_xref="GI:37788085"
                     /translation="MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLG
                     GDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM
                     DYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQITLRDAYVDHLF
                     GYINVKNLTPLKLVINSGNGAAGPVVDVIEARFKALGAPVELIKVHNTPDGNFPNGIP
                     NPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE
                     KNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHY
                     FRDFAYCDSGMIPWLLVTELVCLKGKTLGELVRDRMAAFPASGEINSKLADPVEAINR
                     VEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGNIALMNEQVEFI
                     TKFLNGDGL"
     gene            7181..7738
                     /gene="wbsI"
     CDS             7181..7738
                     /gene="wbsI"
                     /codon_start=1
                     /transl_table=11
                     /product="putative O-acetyltransferase"
                     /protein_id="AAO37696.1"
                     /db_xref="GI:37788086"
                     /translation="MRILKIIISVLLFIKKKRKKIPDSAIINLTSHVDKHSVIGKCCY
                     IGKNVYITKSIIGNYTSIANNVSIGQGEHKVDAVSTSSMFYDNEFEDLTQNDCIIGND
                     VWLGTGVTVLRGVRIGDGAIIGANAVVTKNIPDYCIAVGVPAKVIKRRLPVNVTEKIK
                     ETKWWNDEYEVAKDKIICLTNELKL"
     gene            7735..9177
                     /gene="wzx"
     CDS             7735..9177
                     /gene="wzx"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="AAO37697.1"
                     /db_xref="GI:37788087"
                     /translation="MNKKEIIILLIARILQILISLFTMRLMTTILSNEQMGEYYIFLA
                     IYMLASLGIINPIGQYVNRNTYLWWREGVLTQYINRYINFVLCFSLIYVILYGLGECL
                     FKGINTPFWMLFCYLYIVCLSLNQFLLHTLNILNFKIVFAITTLMTSVLSLSGAYLFI
                     EYSIAKQTVSIYYWVAGIIIGNFISLCICVVYLRSKNTFQKSILKSINVSIKEVFNFC
                     CPIMITTLFIWFQSSGYRFAVEQMFGLKFLGILAVCFAVSGQIMSVIESLVTQIFQPT
                     LFKHMDNVKNRKQHLDFYINENIAIYASVLFFCTFFMREIFLVLVDNKYLPYFYIGII
                     ALWSEFFRISTNTLSLVFFCEKKMKVGIFPYLIGSLSLAFSIVLFRLLNVNLGILIAF
                     AIGVAQLASFIVCLITVKKISYFKINSIFLMKRIIIVLPSVLIAHCIPKFEMINAIHF
                     IIIFGVGLFYLISLATSFMFIKQPGGVYGS"
     gene            9167..10018
                     /gene="wbsJ"
     CDS             9167..10018
                     /gene="wbsJ"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AAO37698.1"
                     /db_xref="GI:37788088"
                     /translation="MEVKIIGGLGNQMFQYATAFAIAKRTHQNLTVDISDAVKYKTHP
                     LRLVELSCSSEFVKKAWPFEKYLFSEKIPHFMKKGMFRKHYVEKSLEYDPDIDTKSIN
                     KKIVGYFQTEKYFKEFRHELIKEFQPKTKFNSYQNELLNLIKENDTCSLHIRRGDYVS
                     SKIANETHGTCSEKYFERAIDYLMNKGVINKKTLLFIFSDDIKWCRENIFFNNQICFV
                     QGDAYHVELDMLLMSKCKNNIISNSSFSWWAAWLNENKNKTVIAPSKWFKKDIKHDII
                     PESWVKL"
     gene            10015..10881
                     /gene="wbsK"
     CDS             10015..10881
                     /gene="wbsK"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AAO37699.1"
                     /db_xref="GI:37788089"
                     /translation="MMEDTKELITVIMPVYNAEKYIYESIKSILVQSYSNFEFIIIND
                     GSKDSSGKIIENFLDDTRIRYINRENKGLVFTLNEAISLSRGNYIARMDADDISHPLR
                     LEKQLNFLLENPDIAVVGCSSFIIDQNSKVINTRKPPLTPLVNKALLFFGPTLTHPSV
                     MFNKMLLGDQLYYSDKYLHVEDYDLWLRLINQYKIANIKDVLFYYRINESGVSQTNLF
                     EQKINAAKAYSEIKYDGKYKDLLEKLEVIHLRHEMEKSKVFQAVLYILLKYEHDSLLF
                     LKLGYILRWLIK"
     gene            10866..11765
                     /gene="wbsL"
     CDS             10866..11765
                     /gene="wbsL"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AAO37700.1"
                     /db_xref="GI:37788090"
                     /translation="MVNKIKIALISTEKANLPEIEAYKEYFSEPFDVSVVNKNDDLSC
                     YDVLWYFMGFKGNKINSKQFLIHEFSSISVPPFPKIKNVIKKFILPKPNLRVFLNKSV
                     QQQFDFNDRVPFCYRDMGVNYKPVVERNNKKYDILYVGAITGRKLDDALNLILSYKLD
                     CKIAILGKVPEKFKEKYKNADVIFLGQVPYNRVATIIAESNLCLNWIPNIYPYNMQTS
                     TKFLEYLAQNKQIISNSYPWVDSYCQQHNIDYININDSNSIRQALNSVIIQKSTHIPP
                     SWREVIMNSGIENHIKSYFEVTK"
     gene            11762..12805
                     /gene="wzy"
     CDS             11762..12805
                     /gene="wzy"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="AAO37701.1"
                     /db_xref="GI:37788091"
                     /translation="MISYGVLFLFSYINAVLQKRVTVTLLFFIMIIVSFFKYNIGFDW
                     GNYHEIYLQQGDGFFFYEPLFSLLIILSNKVALEYKYFISMCSLITLIVYYSGMRCFA
                     RDIKELALALTYFVVSYCYFEHFNIIRQTLAIALFFYSWKYIIETNFIMYSLFIFFAS
                     MIHAAAVVLLPFYFFLRIDNFKPVYYGIVVLFIIIVVRFDINSILLSSLNLFKNFDFV
                     ARYLANSTDLADFASKKSDLGLSKMYPAIIFVFCCFWGGIRLESRRDYVFFNAGFIAI
                     TLLLLSYQVDILFRFFSFFETSFVLLYCIIFSGFNKKSKIILHMVNLIVYTVMTFNML
                     SVMGLIPYESYIF"
     gene            13276..14295
                     /gene="galE"
     CDS             13276..14295
                     /gene="galE"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose C4-epimerase"
                     /protein_id="AAO37702.1"
                     /db_xref="GI:37788092"
                     /translation="MAILVTGGAGYIASHTILSLIEQGNEVIIIDNLSNSYYDSLLKI
                     KEITGCDCLFYKGDILDKKLLLKIFDENNITAVMHFAGAKSVSESVIRPLQYYRNNVS
                     GTFSLVEAMEESGVENLIFSSSATVYGEPKIIPVNESCAIGGTTNPYGTSKLFVENFL
                     RDYSKASPNFKTIVLRYFNPIGAHSSGKIGEDPNGIPNNLMPFICQVAIGKQKTLKIY
                     GNDYPTKDGTGIRDYIHVMDLAEGHVAALNNINQGANYRVYNLGTGIGYSVLELLEAF
                     QKVTTRRVPYVFTKRRSGDIAECWSDPTKAYEELGWKARRGLEDMIRDAWNWQQKNPN
                     GFKKV"
     gene            14402..15808
                     /gene="gnd"
     CDS             14402..15808
                     /gene="gnd"
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate-6-phosphate dehydrogenase"
                     /protein_id="AAO37703.1"
                     /db_xref="GI:37788093"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            16059..17225
                     /gene="ugd"
     CDS             16059..17225
                     /gene="ugd"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="AAO37704.1"
                     /db_xref="GI:37788094"
                     /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISP
                     IVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPNTNYFNTSSVESVIK
                     DVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPHVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD"
     gene            17335..18348
                     /gene="wzz"
     CDS             17335..18348
                     /gene="wzz"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant"
                     /protein_id="AAO37705.1"
                     /db_xref="GI:37788095"
                     /translation="MRTWKFPSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQLWRGKM
                     TIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSD
                     LQETLIGRFSYAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKL
                     AQYIQQVDEKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQY
                     ANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDI
                     ENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLRRNALRNY
                     NAK"
BASE COUNT     5703 a   3465 c   4110 g   5735 t
ORIGIN
        1 gctttctgcc gatatttggc cggaactgga gcgcactcag cctggtgcat ggggacgtat
       61 tcagctgact gatgctattg ccgaactggc gaaaaaacag tccgttgatg caatgctgat
      121 gactggtgac agctacgact gcggtaaaaa aatgggctat atgcaggcgt ttgtgaagta
      181 tggactgcgc aacctgaaag aaggggcgaa gttccgtaaa ggcattgaga agctgttaag
      241 cgaataatga aaatctgacc ggatgtaacg gttgataaga aaattataac ggcagtgagg
      301 attcgtggcg aaagtaattt gttgcgaata ttcctgccgt tgttttatat aaataatcag
      361 aataacaacg agttagcaat aggattttag tcaaagtttt ccaggatttt ccttgtttcc
      421 agagcggatt ggtaagacaa ttagcgtttg aatttttcgg gttttgcgcg agtgggtaac
      481 gctcgtcaca tcgtaggtat gcatgcagtg ctctggtagc tgtaaagcca ggggcggtag
      541 cgtgtttatt tcatattggt gcagctagtt taccattata taattgtaag ttaatcactt
      601 cgaatgtgca ttttcaggaa ttagatctaa tgattaaaat attgcatata catcttagta
      661 gtaaaattag cggagcccaa agagtttctt tagatgaaat gaaaacgttg agtaatcatt
      721 actcacagta tatggtttgc tccaaagaag gcgattttac tcaagaagcg gatcgtattg
      781 gagtaaaaac ttatgtaata gaaaccttag tcagagaaat ttcacctcta aaagactttt
      841 attcattaat aaaattatat aaatttatca agcaagaaaa attcgatatt attcatacgc
      901 attcctcaaa aagtggtttt ctcgggcgat tagcagcaaa actcgcgggc acaaaacaaa
      961 taatccatac ggtgcatgga tttgcgtttc cttcaacatc aaatagagtt gtaaagctta
     1021 tatatttttt aatggaatac tttgcttcat tatgttcatc agtgattatc gtaatgaatg
     1081 agaatgatga gaaaatagcc agaaaatatt tttcttctgc tccttggacc aaagtgactc
     1141 tcttaaacaa tgctgttgat ataaagaagt ttcaaaagcg atatattgga atcgaatcaa
     1201 aaagtgaaat aaatgagcaa aagaaattta agatggtcat gattggacgc ttatgtgagc
     1261 aaaaaaaccc actattaatt ataaatgcgt taaaaatatt gggtgaccat tattatgtgg
     1321 attttgttgg tgatggccca ctaagatcag acttagaaag tcaaatagca aaacgtggtc
     1381 ttgaaaaaag agtccgttta ttaggatggt gctcgtctgt agaagaaatt atttttaaat
     1441 atgacttgtt tttattgcct tcaaaatggg aaggaatgcc attagctata cttgaggcaa
     1501 tggcatcaaa agtaccggtt ttgtgttcga atattgatgc taatgcatat cttattaaca
     1561 aaacttcagg ttttcttttt aacaatgatg atgctaaaga tcttgctaag aatataaaat
     1621 atatttttga taatgtagat gtacgtagaa aagttgcaga ggatgcatat ttggcagtag
     1681 ttaaggattt tgagttatca gaacgtacaa agatattaga atcaatttac actaataatt
     1741 attttttata agtgaggtta tttatggaca aaaataaaat tgcactcatc accggtgtaa
     1801 ccggacaaga tggttcttac ctggcagagt ttctgctgga aaaaggttac gaggtgcatg
     1861 gtattaagcg tcgcgcatcg tcattcaaca ccgagcgcgt ggatcacatt tatcaggatc
     1921 cgcacacctg caacccgaaa ttccatctgc attatggcga cctgagtgat acctctaacc
     1981 tgacgcgcat tttgcgtgaa gtacagccgg atgaagtgta caacctgggc gcaatgagcc
     2041 acgttgcggt ctcttttgag tcaccagaat ataccgctga cgtcgacgcg atgggtacgc
     2101 tgcgcctgct ggaggcgatc cgcttcctcg gtctggaaaa gaaaacccgt ttctatcagg
     2161 cttccacctc tgaactgtat ggtctggtgc aggaaattcc gcagaaagaa accacgccgt
     2221 tctacccgcg atctccgtat gcggtcgcca aactgtacgc ctactggatc accgttaact
     2281 accgcgaatc ctacggcatg tacgcctgta acggtattct cttcaaccat gaatccccgc
     2341 gccgcggtga aactttcgtt acccgcaaaa tcacccgcgc aatcgccaac atcgcccagg
     2401 ggctggagtc gtgcctgtac ctcggcaata tggattccct gcgtgactgg ggccatgcca
     2461 aagactacgt aaaaatgcag tggatgatgc tgcaacagga acagccggaa gatttcgtta
     2521 ttgccaccgg cgttcagtac tccgtgcgtc agttcgtgga aatggcagca gagcaagtcg
     2581 gaatcaaatt gcgctttgaa ggtgtcggcg taaatgagaa gggaatcgtt gtttctgtta
     2641 ctggtaagga tgccccagcc gttaaatccg gagatataat tgttaaggtt gacccgcgct
     2701 atttccgtcc ggcagaagta gaaacgctgc tcggcgaccc gaccaaagcg cacgaaaaac
     2761 tgggctggaa accggaaatc accctcagag agatggtgtc tgaaatggtg gctaatgacc
     2821 tcgaagcggc gaaaaaacac tctctgctga aatctcatgg atttaatgtt agtttatctc
     2881 aggaataact aatgttttta caaagaattt ttattgctgg ccatcgcggg atggtcggtt
     2941 ccgccatcag gcggcagctc gaacagcgcg gtgatgtgga actggtatta cgcacccgcg
     3001 acgaactgaa cctgctggac agccgcgccg tgcatgattt ctttgccagc gaacgtatcg
     3061 accaggtcta tctggcggcg gcgaaagtgg gcggcattgt tgccaacaac acgtatccgg
     3121 cggatttcat ctaccagaac atgatgattg agagcaacat cattcacgcc gcgcatcaga
     3181 acgacgtgaa caaactgctg tttctcggat cgtcctgtat ctacccgaaa ctggcaaaac
     3241 agccgatggc agaaagcgag ttattgcagg gcacgctgga gccgaccaac gagccttatg
     3301 ccattgccaa aatcgccggg atcaaactgt gcgaatctta caaccgccag tacggacgcg
     3361 attaccgctc agtcatgccg accaacctgt atggcccgca tgacaacttc cacccgagta
     3421 attcgcatgt gatccctgca ttgctgcgtc gcttccacga ggcgacggca cagaatgcac
     3481 cggacgtggt ggtatggggc agcggtacac cgatgcgtga attcctgcac gtcgatgata
     3541 tggcggcggc gagcattcac gtgatggagc tggcgcatga agtctggctg gagaacaccc
     3601 agccgatgct gtcgcacatt aacgttggta cgggcgttga ctgcactatc cgcgagctgg
     3661 cgcaaaccat cgccaaagtg gtgggttaca aaggtcgggt ggtttttgat gccagtaaac
     3721 cggatggcac gccgcgcaaa ctgctggatg tgacgcgcct gcatcagctt ggctggtatc
     3781 acgaaatctc actggaagcg gggcttgcca gcacttacca gtggttcctt gagaatcaag
     3841 accgctttcg ggggtaatga tgtttttacg tcaggaagac tttgccacgg tagtgcgctc
     3901 cacaccactt gtctctctcg actttattgt cgagaacagt cgcggcgagt ttctgcttgg
     3961 caaaagaacc aaccgcccgg cgcagggtta ctggtttgtg ccgggagggc gcgtgcagaa
     4021 agacgaaacg ctggaggccg catttgagcg gctgacgatg gcggaactgg ggctgcgtct
     4081 gccgataaca gcaggccagt tttacggtgt ctggcagcac ttttatgacg ataacttttc
     4141 cggcacggat ttcaccactc actatgtggt gctcggtttt cgcttcagag tagcggaaga
     4201 agagctgtta ctgccggatg agcagcatga cgattaccgc tggctgacgc cggacgcact
     4261 gctcgccagt gaaaatgttc acgctaacag ccgtgtttat tttaataatg atccacgtgc
     4321 aatcattggc ttaaataaaa aggaagtcaa aaatgtctga tgtacctttg attgctgtcg
     4381 taatggctgg tggtacgggg agccgccttt ggcctctgtc tagagaacac tatcctaagc
     4441 aatttttgca actatcaggt gagagttctt tattgcaatc aactttatta cgactgtcaa
     4501 ctctttcctg cgaaactcca ttagtaataa caaatgagca acatcgcttt gtggttgcag
     4561 aacaattacg tcaaattgat cagttaagag ataatattat tcttgagcca tgtggaagaa
     4621 atacggctcc cgccatagct ctttcagcat ttacagcttt gaagcgtaat gaacaacagg
     4681 atcctatttt gttgattctc gcagctgacc atattataag caaagcggat gttttttgtg
     4741 acgctattca aaaatcgaaa actgtagctg aacaggggaa tattgtaacc tttgggatta
     4801 tacctgaata tgcggaaaca ggttatggtt atataaaaaa aggagatcct tttaaaattt
     4861 taccaaatat tactcatgat aagttttatc atgtccaaca atttattgaa aaacctaacc
     4921 attcgacggc agaagagtat gtttccacag gagaatatct ctggaatagt ggaatgttta
     4981 tgtttaaagc atcagtatat ttagaggaat tgaaaaagca caggcctgat atatacgaaa
     5041 tctgtgagca gacagcttca ttatcctata acgatcttga tttcatacga ttgcctaaac
     5101 atattttcca agattgtccg tcggaatcaa ttgattttgc ggttatggaa aaaacaaaaa
     5161 attgcattgt tcgtccagta gacatcgggt ggagtgatgt aggttcttgg cattctttgt
     5221 gggatattag tgataaaacg caggatggag atgtctgtaa aggtgatatt ctaacttata
     5281 acactaaaaa caattatata tattctgaat cagccctagt ggctgctgta ggtgtagaag
     5341 atatagttat tgttcaaaca aaagatgcta ttctcgtgtc caaaaaaact gaggttcagg
     5401 atgtaaaaaa aatagtagaa atgcttaagg aacaagagcg ctcagagtat atatcgcatc
     5461 gagaggagtt tcggccttgg ggaaaatttg atgcgataga tcagggagaa cgatataaag
     5521 ttaaaaagat agttgtgaaa cccggcgaag gagtatcctt acgaatgcac catcatcgtt
     5581 ctgagcattg gattgttctt tccggcacag caaaagtaac tttaaacgat aaaacagtat
     5641 tgcttgctgc aaatgaatca atctacattc ctctaggagc aacgtatagt cttgaaaatc
     5701 caggaataat ccctctgaat cttattgagg ttagttcagg cgattattta ggtgaggatg
     5761 atattgtacg gcaaaaagaa cgctacagaa tagatgacta atatatgaaa aaattaacct
     5821 gctttaaagc ctatgatatt cgcgggaaat taggcgaaga actgaatgaa gatatcgcct
     5881 ggcgcattgg tcgcgcctat ggcgaatttc tcaaaccgaa aaccattgta ttaggcggtg
     5941 atgtccgcct caccagcgaa accttaaaac tggcgctggc aaaaggttta caggatgcgg
     6001 gcgtcgatgt gctggatatt ggcatgtccg gcaccgaaga gatctatttc gccacgttcc
     6061 atctcggcgt ggatggcggc attgaagtta ccgccagcca taacccgatg gattataacg
     6121 gcatgaaact ggtgcgcgaa ggggctcgcc cgatcagcgg tgataccgga ctgcgcgacg
     6181 tccagcgtct ggcagaagcc aacgacttcc cccccgtcga tgaaaccaaa cgcggtcgct
     6241 atcagcaaat taccctgcgt gacgcttacg ttgatcacct gttcggttat atcaatgtca
     6301 aaaacctcac gccgctcaag ctggtgatca actccgggaa cggcgcagcg ggtccggtgg
     6361 tggacgttat cgaagcccgc tttaaagccc tcggcgcacc ggtggaattg atcaaagtgc
     6421 acaacacgcc ggacggtaat ttccccaacg gtattcctaa cccgctactg ccagaatgcc
     6481 gcgacgacac ccgcaatgcg gtcatcaaac acggcgcgga tatgggcatt gcctttgacg
     6541 gtgattttga tcgctgcttc ctgtttgacg aaaaagggca gtttattgag ggctactaca
     6601 ttgtcggcct gctggcagaa gcattcctcg aaaaaaatcc cggcgcgaag atcatccacg
     6661 atccacgtct ctcctggaac accgttgatg tggtgaccgc cgcgggcggc actccggtga
     6721 tgtcgaaaac cggacacgcc tttattaaag aacgtatgcg caaggaagac gccatctacg
     6781 gtggcgaaat gagcgcccac cattacttcc gtgatttcgc ttactgcgac agcggcatga
     6841 tcccatggct gctggtcacc gaactggtat gcctgaaagg aaaaacgctg ggcgaactgg
     6901 tgcgcgaccg gatggcagca tttccggcaa gcggtgagat caacagcaaa ctggcggacc
     6961 ccgttgaggc gattaaccgc gtggaacagc attttagccg tgaggcgctg gcggtggatc
     7021 gcaccgatgg catcagtatg acctttgccg actggcgctt taacctgcgc tcctccaaca
     7081 ccgaaccggt ggtgcgcctg aatgtggaat cgcgcggtaa tatagcatta atgaatgaac
     7141 aggttgaatt tattacaaaa tttttaaacg gtgatggttt atgagaatat taaaaattat
     7201 tataagtgta ttgttgttta taaaaaagaa aagaaaaaaa ataccggact cagcaataat
     7261 aaacttaaca agtcatgtgg ataaacattc agtaattgga aagtgttgtt atatagggaa
     7321 aaatgtatat ataactaaaa gtatcattgg gaattacaca tctattgcaa ataatgtctc
     7381 aattggtcaa ggtgaacata aggttgatgc agttagtaca agttcgatgt tctacgataa
     7441 tgagttcgaa gatttaacac aaaacgattg tattataggt aatgatgtgt ggctcggtac
     7501 aggagttact gtattacgag gagtaagaat tggtgatggt gctattattg gtgctaatgc
     7561 cgttgtcaca aaaaatattc cagattattg tattgcggta ggagtacctg cgaaagtaat
     7621 caaaagaaga ttaccagtaa atgttactga aaaaataaaa gagactaaat ggtggaatga
     7681 tgaatatgaa gtggcgaagg ataaaattat ttgcttaaca aatgaattaa agttatgaac
     7741 aaaaaagaaa taattatctt gcttatagcc agaattctac agattctcat tagtttattc
     7801 acaatgagat tgatgacaac gattttaagc aatgagcaaa tgggggagta ttatattttt
     7861 ttagcaatct atatgttggc atcattgggt ataattaatc caataggaca atatgtgaat
     7921 cgcaacactt atttatggtg gagagaggga gtactaaccc aatacattaa tcgatatatt
     7981 aattttgttt tgtgtttttc gcttatttat gtgattttgt atggacttgg tgaatgtttg
     8041 tttaaaggaa taaatacacc attttggatg ttattctgtt atttatatat agtatgttta
     8101 tctctaaatc aatttctatt acatacttta aatatcttaa attttaagat agtatttgcc
     8161 attacgacgt tgatgacttc tgtattaagt ttatcagggg catatttatt tattgaatat
     8221 agcatagcta aacaaactgt tagtatatat tactgggttg caggaatcat aattggcaat
     8281 tttatttctt tatgtatatg cgttgtatat ctgagaagta aaaatacgtt ccaaaaatca
     8341 attcttaaat ctatcaatgt aagcataaaa gaagttttta atttttgctg tccaattatg
     8401 ataacaactt tgttcatttg gtttcaaagc tctggatatc gatttgctgt cgagcaaatg
     8461 tttggcttaa agtttttagg tatactagct gtatgttttg ctgtgtcagg gcaaataatg
     8521 tcagtgattg agtctttagt gacacagata tttcaaccaa cattatttaa gcatatggat
     8581 aatgtcaaaa atagaaagca acatctagat ttttatatta atgaaaatat agcaatttat
     8641 gctagtgtat tatttttttg tactttcttt atgcgcgaaa tatttttggt attagttgac
     8701 aataaatatc ttccttactt ctatataggt ataatagctt tatggagtga attttttagg
     8761 atatcaacca atactttgtc tttagtgttt ttttgcgaaa agaaaatgaa ggtaggaatt
     8821 tttccttatt taattggctc attaagcctg gctttttcga tcgtcttgtt caggttgtta
     8881 aatgtaaatt tgggtatttt aatagctttt gctattgggg ttgcacaatt ggcctccttt
     8941 atcgtttgct taattacggt aaaaaaaatc tcttatttta aaataaattc catcttctta
     9001 atgaagagga taataatagt actaccctct gtgttaattg cccattgcat tcctaaattt
     9061 gaaatgatta atgctatcca ttttattatc attttcggtg tcggtttatt ttacttaatc
     9121 tctttagcta cttcttttat gtttattaaa caaccaggag gtgtttatgg aagttaaaat
     9181 tattgggggg cttggcaatc agatgtttca gtatgcaact gcatttgcta ttgcaaaaag
     9241 aactcatcaa aatttgactg ttgatatatc tgatgcagta aaatataaaa ctcatccatt
     9301 aagattagtt gaattatctt gtagttcaga atttgtaaaa aaagcatggc catttgaaaa
     9361 atacttattt tccgaaaaaa tcccacattt catgaaaaaa ggaatgttca gaaagcatta
     9421 cgttgagaaa agtttagagt atgatccaga tattgatacc aaaagtataa ataaaaaaat
     9481 cgtcggttat tttcaaactg aaaaatattt taaggaattt aggcatgagt tgataaagga
     9541 atttcaacct aaaaccaagt ttaatagtta tcaaaatgaa ttgcttaatt taattaaaga
     9601 aaatgatact tgttcattac atattagaag aggtgattat gtttccagta aaatagcaaa
     9661 tgaaactcat ggcacatgta gtgaaaaata ttttgaacgt gccattgatt atttgatgaa
     9721 taaaggtgtt attaataaaa aaacccttct cttcattttt tctgatgata taaagtggtg
     9781 cagggaaaat atatttttta ataatcaaat atgttttgtt caaggtgatg cttatcatgt
     9841 tgaattagat atgctgctta tgagtaaatg taaaaataat ataatttcaa atagttcttt
     9901 cagttggtgg gctgcttggt taaatgaaaa taaaaataaa acagtaattg ctccgagtaa
     9961 atggtttaag aaagatatta aacatgatat tattcccgaa tcgtgggtaa aattatgatg
    10021 gaagatacaa aagaattaat aacagtaata atgcctgttt ataatgcgga aaaatacata
    10081 tatgaatcta taaaaagtat tttggtgcag tcatattcta attttgagtt catcattatt
    10141 aatgatggct caaaagattc ttctggaaaa attattgaaa actttctcga tgatacgagg
    10201 atacgatata taaatcgtga aaataaaggt ttggtcttca ctctgaatga agctatttcg
    10261 ttatcaagag gaaattatat tgctcgaatg gatgctgatg atatttcaca tcccctacga
    10321 ttagaaaagc aactaaattt tctactagaa aatccagata tagccgtagt tgggtgttct
    10381 tcttttatta ttgaccaaaa ttctaaggtt ataaatacac gaaaaccacc tttgacacct
    10441 ttagtaaata aagcattgct attttttggc ccaacattaa ctcatccatc agtgatgttt
    10501 aataaaatgc tacttggaga tcagctttac tacagtgata aatatcttca tgttgaagat
    10561 tatgacttgt ggttgaggtt aattaatcaa tacaaaatag ctaatatcaa agatgttctt
    10621 ttttactatc gaattaatga gtcaggtgtt tcacagacta atttatttga acaaaaaatt
    10681 aatgctgcta aagcatatag tgaaattaaa tatgatggta agtataaaga cttactggaa
    10741 aagttagaag tcatacacct gagacatgaa atggagaaaa gtaaggtctt tcaggccgta
    10801 ttatatatat tattaaagta tgaacatgat tcattattat ttttaaaatt aggatatata
    10861 ttacgatggt taataaaata aaaatagcac taataagtac agaaaaagct aatcttcctg
    10921 aaattgaagc ctataaggag tatttttcgg agccatttga tgtctctgtt gttaataaaa
    10981 atgatgattt aagttgttat gatgttttat ggtactttat ggggtttaaa ggtaataaaa
    11041 taaactctaa acagttcttg attcatgagt tttcctcaat ttcagtacca ccatttccaa
    11101 aaataaaaaa cgtcatcaag aaatttattt tgcctaaacc taatttgagg gtttttttaa
    11161 ataaatcagt gcaacaacaa ttcgatttta atgatagagt tcctttttgt taccgagata
    11221 tgggcgtcaa ttataaacca gtagttgaaa gaaataataa aaaatatgat atattatatg
    11281 tgggggcaat tactggtaga aaactagatg atgcattaaa tttgattttg tcatataaat
    11341 tagattgtaa aatcgcaatt cttggtaaag tgccagaaaa gtttaaagaa aaatataaaa
    11401 atgctgatgt tatatttctt gggcaagttc cttataatcg ggtagccacc attattgcag
    11461 aatctaactt gtgtttaaat tggattccga atatttatcc atataacatg cagacatcaa
    11521 caaaattctt agagtatctg gcacaaaata aacaaataat atcgaatagc tacccttggg
    11581 ttgactctta ttgtcaacag cataatattg actatattaa tatcaatgat tccaattcta
    11641 ttcgacaagc attgaactca gtcataatcc aaaaatcaac acatatcccc ccaagttggc
    11701 gagaggttat tatgaatagc gggatagaaa atcacattaa atcatatttt gaggtaacaa
    11761 aatgatttct tacggagtgc tatttctctt ctcttatatc aatgctgtac ttcagaagag
    11821 agtaaccgta acattactat tttttataat gataattgtt tctttcttta aatataatat
    11881 tggatttgat tgggggaatt atcatgaaat ttaccttcag caaggagatg gctttttttt
    11941 ttatgaaccc ctattttctc tcttaattat tctttccaat aaggttgcat tagaatataa
    12001 atattttata tcaatgtgct cattaattac actgattgtt tattattctg gtatgcggtg
    12061 ttttgcaaga gatataaaag agttagcttt agcattaact tattttgttg tctcttattg
    12121 ctactttgaa cactttaata ttattcgaca aactttagca atcgctttat tcttttatag
    12181 ttggaaatat attattgaga ctaactttat aatgtatagc ctctttattt tttttgcatc
    12241 tatgattcat gcggcggcgg ttgtattgct cccattttac ttttttctta gaattgataa
    12301 ttttaaaccc gtatattatg gtatagtggt cttatttatt attattgttg ttagattcga
    12361 tattaacagc atccttttaa gttcacttaa tttatttaaa aatttcgatt ttgtagctag
    12421 gtatttagca aattcaacag atttggctga ctttgcatca aaaaaatctg atcttggatt
    12481 aagtaagatg tacccagcaa ttatatttgt tttctgttgt ttttggggag ggattaggtt
    12541 agagtctcga agagactatg ttttttttaa tgctggcttt attgcaataa ctttactgct
    12601 cttaagctat caggttgata ttttgtttag atttttctct ttttttgaga cttcatttgt
    12661 cttgttgtac tgcattattt tttctggttt taataaaaaa agtaaaatta tactgcatat
    12721 ggttaattta attgtatata cggtaatgac atttaacatg ttatcagtaa tgggcttgat
    12781 tccttatgaa tcatacattt tctaataagc ttccctcagt tgtttgttgt atagtaatat
    12841 tttaatatca ttgcagtgtg taattattgt caataagcta atttctgtta tttgcatgat
    12901 taattcagtt tgcaatgctt gatgtaaaaa gataaagtac acccgtttac acaatgttta
    12961 ttttggcatg tcaagtataa gttctaaata atacgtttgt aatgtttagc atgtaaacat
    13021 aatagttaaa taatattaaa catgcaacat gccatttgtt attccaataa aacatatgtg
    13081 ttgtatgaat tatttaatgt ggaaagtggt tgcgtattat aaattgttca tattgacgtt
    13141 taagtctttt ataactccat gcttgcatgt taaaaatatt tcgctatata ttatggtagg
    13201 tggtttttat ctaggcagat ttgtctattt aactctaaat ctaaatcgct taagaaagta
    13261 tgagtaggag tatttatggc tattctcgtt acaggtggtg ctggttatat tgcatcacat
    13321 actatactga gtttgataga gcagggtaat gaagtaatta ttattgataa tttatcaaat
    13381 tcatattatg attcgttatt gaaaataaaa gagattactg gatgtgattg tcttttttat
    13441 aaaggagata tccttgacaa aaaactcttg ctaaaaatat ttgatgaaaa taatatcact
    13501 gctgtgatgc attttgctgg tgcaaagtct gtaagtgaat ctgttatcag acctttgcaa
    13561 tactatcgaa ataatgtctc tggcactttt tctttagttg aggcaatgga ggagtctggt
    13621 gtagaaaatt taatatttag ctcttcagca actgtctatg gtgagccaaa gattattcct
    13681 gtgaatgaaa gttgtgctat aggtggtact acaaatccgt atggaacgtc caagttattt
    13741 gtagagaact ttttgcggga ttattctaag gcatccccta attttaaaac tatagtatta
    13801 agatatttta accctatcgg tgctcactca tctggaaaaa taggtgaaga tcctaacgga
    13861 attccgaata acttgatgcc ctttatatgc caggttgcta tcggtaaaca aaaaacgctc
    13921 aagatctacg gaaatgatta tcctactaaa gatggtactg ggattcgcga ttatattcat
    13981 gttatggatc ttgctgaagg tcatgttgct gcattaaata atattaatca aggagctaat
    14041 tatagagttt acaaccttgg aacaggaatt ggatactctg tgttggaatt attagaagca
    14101 tttcagaaag ttacaactcg gagagttccc tatgttttta ctaaaaggcg ttcaggtgat
    14161 attgctgaat gttggtctga tcctaccaaa gcgtatgaag aattaggatg gaaagcaagg
    14221 cgagggttag aagatatgat tcgtgatgca tggaattggc agcaaaaaaa tccaaatgga
    14281 tttaagaaag tttaataaaa atgaaacgat atattaagtg ttagcttgtt taattaattt
    14341 aaagttaata ttatttacat taatatgtaa tgaaaatgat attctatgac aggagtaaac
    14401 aatgtcaaag caacagatcg gcgtcgtcgg tatggctgtg atgggacgca acctcgcgct
    14461 taacatcgaa agccgtggtt ataccgtctc tattttcaac cgttcccgtg aaaagacgga
    14521 agaagtgatt gccgaaaatc caggcaagaa actggttcct tactatacgg tgaaagagtt
    14581 tgttgaatct ctggaaacgc ctcgtcgcat cctgttaatg gtgaaagcag gtgcaggcac
    14641 ggatgctgct attgattccc tcaagccata cctcgataaa ggcgacatca tcattgatgg
    14701 tggtaatacc ttcttccagg acaccattcg tcgtaatcgt gagctttctg ccgaaggctt
    14761 taacttcatt ggtaccggtg tctccggtgg tgaagaaggc gcgctgaaag gtccttccat
    14821 tatgcctggt gggcagaaag aagcctatga actggttgcg ccgatcctga ccaaaattgc
    14881 cgcagtggct gaagacggtg agccatgcgt tacctatatt ggtgccgatg gtgcaggtca
    14941 ctatgtgaag atggttcaca acggtattga atacggtgat atgcagctga ttgctgaagc
    15001 ctattctctg ctaaaaggtg gcctgaacct caccaacgaa gaattggcgc agacctttac
    15061 cgagtggaat aacggtgaac tgagcagcta cctgatcgac atcaccaaag atatcttcac
    15121 caaaaaagat gaagacggta actacctggt tgatgtgatt ctggatgaag cggctaacaa
    15181 aggtacgggc aaatggacca gccagagtgc gctggatctc ggcgaaccgc tgtcgctgat
    15241 taccgagtct gtgtttgcac gttatatctc ttctctgaaa gatcagcgtg ttgccgcatc
    15301 taaagttctc tctggcccgc aagcacagcc agcaggcgac aaggctgagt tcatcgaaaa
    15361 agttcgccgt gcgctgtatc tgggcaaaat cgtttcttac gctcagggct tctctcagct
    15421 acgcgccgcg tctgaagagt acaactggga tctgaactac ggcgaaatcg cgaagatttt
    15481 ccgtgctggc tgcatcatcc gtgcgcagtt cctgcagaaa atcaccgatg cttatgccga
    15541 aaatccgcag atcgctaacc tgctgctggc tccgtacttt aaacaaattg ccgatgatta
    15601 ccagcaggcg ctgcgtgatg tcgttgctta tgcagtacag aacggtatcc cggttccgac
    15661 cttcgccgct gcggttgcct attatgacag ctaccgcgcc gctgttctgc ctgcgaacct
    15721 gatccaggca cagcgtgact atttcggtgc gcatacttat aagcgcattg ataaagaagg
    15781 tgtgttccat accgaatggc tggattaatc tgatttaatc aacaataaaa ttgaggcccg
    15841 gcgtatattg taccgggctt ttttttgcca attatcttat agactaaata tcactgctta
    15901 atattaactt aataaatatc agctattctt ataaagaaaa tctgaattgt ttttcgctgc
    15961 gttgaccatc gaacaacgta gcgttaaaac ttttagctct tatcaggatg ttaaaaacat
    16021 catgattcac agttaagtta attctgagag catgaacaat gaaaatcacc atttccggta
    16081 ctggctatgt aggcttgtca aacgggcttc taatcgctca aaatcatgag gttgtggcat
    16141 tagatatttt accgtcacgc gttgctatgc tgaatgatcg gatatctcct attgttgata
    16201 aggaaattca gcagtttttg caatcagata aaatacactt taatgccaca ttagataaaa
    16261 atgaagccta ccgggatgct gattatgtca tcatcgccac tccaaccgac tatgatccta
    16321 acactaatta tttcaataca tcgagtgtag aatcagtaat taaggacgta gtagagataa
    16381 atccttatgc ggttatggtc atcaaatcaa cggtacccgt tggctttacc gcagcgatgc
    16441 ataagaaata tcgtactgaa aatattattt tctctccgga atttctccgt gagggtaaag
    16501 ccctttacga taatctccat ccttcacgta ttgtcatcgg tgagcgttca gaacgcgcag
    16561 aacgttttgc tgctctgtta caggaaggcg cgattaagca aaatatcccg accctgttta
    16621 ccgactcaac cgaagcagaa gcgattaaac ttttcgctaa tacctatctg gcgatgcgcg
    16681 tagcgtactt taatgaactg gatagctatg cagaaagttt aggtctgaat actcgccaga
    16741 ttatcgaagg cgtttgtctc gatccgcgta ttggcaacca ttacaacaat ccgtcgtttg
    16801 gttatggtgg ttattgtctg ccgaaagata ccaagcagtt actggcgaac tatcagtctg
    16861 tgccgaataa cctgatctcg gcaattgtcg atgcaaaccg cacgcgtaaa gattttattg
    16921 ccgatgccat tttgtcacgc aaaccgcatg tggtgggtat ttatcgcctg attatgaaga
    16981 gcggttcaga taacttccgt gcgtcttcta ttcaggggat tatgaagcgt atcaaggcga
    17041 aaggtgttga agtaatcatc tacgagccag tgatgaaaga agactcattc ttcaactctc
    17101 gcctggaacg tgatctcgcc accttcaaac aacaagccga cgtcattatc tccaaccgta
    17161 tggcagaaga gcttagggat gtggcagata aggtctacac ccgcgatctc tttggcagcg
    17221 actaacatct tgttatcagg gctatttacg ccctgattga cttttgttac ttacgcaaca
    17281 attcattatt tttatcactt atcctatagc attcacgagg attatcgcta aactatgcgg
    17341 acttggaaat ttccgtcagt tagggtaatg atgagagtag aaaataataa tgtttctggg
    17401 caaaaccatg acccggaaca gattgatttg attgatttac tagtgcagtt gtggcgtggc
    17461 aagatgacaa tcatcatttc cgtcattgtg gctattgccc tggctattgg atatttggca
    17521 gtagcgaagg agaaatggac gtcaacagca attatcactc agcccgacgt ggggcaaatt
    17581 gctggctata acaatgctat gaatgttatc tatggtcagg ctgcaccgaa agtatcggat
    17641 ttgcaggaga cgttaattgg tcgcttcagt tatgccttct ctgcattagc agaaacgctg
    17701 gataatcagg aagagccaga gaaacttacc atcgaacctt ctgttaagaa ccagcaatta
    17761 ccattgactg tttcttatgt tgggcaaaca gcagagggcg cacaaatgaa gttggcccaa
    17821 tacattcagc aagttgatga aaaagtgaat caagagctag aaaaggatct caaagacaac
    17881 attgctctgg gacggaaaaa cttgcaggac tctttaagaa cgcaggaagt agtcgcgcag
    17941 gagcagaaag atctgcgtat ccgtcagatt caggaagcgt tgcagtatgc gaatcaggcg
    18001 caggtgacaa aaccacaggt tcagcagact gaagatgtga cgcaagatac gttgttcctt
    18061 ttggggagcg aagctctgga gtcgatgatt aagcatgagg cgactcgtcc gttagtgttc
    18121 tcaccaaact actatcagac acgtcaaaac ctgctggata tcgaaaactt aaaggttgat
    18181 gatcttgata ttcatgctta ccgctatgta atgaaaccga cgttacctat tcgtcgcgat
    18241 agtccgaaaa aggcaattac attgattctg gcagtgctgc tgggcggcat ggttggcgcg
    18301 gggattgtgt tgaggcgtaa cgctctgcgt aattacaacg cgaagtaatc tttgcagttt
    18361 taaagaaaaa gggcaggggg gtgacacctt gcccgttttt tttgccggat gcgacaacaa
    18421 tatcgcatcc gcttaccccg caactcactg atgccgttta cgcaggttct caatcaccgt
    18481 cgttaagtcc agatcctgat cctgcaacag caccagcagg tgatacatca aatcagacgc
    18541 ctcgttggtc agctcaaagc ggtcatgtac cgtcgctgcc agtgcggttt ccaccccttc
    18601 ttcacctact ttctgcgcaa tgcgtttagt gccgctggca tacagtttgg cagtgtaaga
    18661 ggtttccggg tcggcagatt tgcgttcggc gagcagttgt tccagttgat acaggaacag
    18721 ccattggtga gcggtgtcgc cgaagcagct gctggtgcct ttgtggcagg ttggtccgat
    18781 aggattcgcc agtaccagta gcgtgtcgtt gtcgcagtcc ggcgcaatat ttactacgtt
    18841 gaggaaattg cccgacgttt cgcctttggt ccacagtcgc tgtttagtgc gcgagaagaa
    18901 ggtgactttg ccgctttcga tggttttgtc taaggcttcc gggttcatat agcccagcat
    18961 taacacttcg ccggataccg cgtgttgcac aatcaccggc atcagtccgt cgg
//
