LOCUS       AB812080               22184 bp    DNA     linear   BCT 13-DEC-2014
DEFINITION  Escherichia coli genes for O-antigen biosynthetic locus, partial
            sequence, strain: 99-4473.
ACCESSION   AB812080
VERSION     AB812080.1  GI:733167514
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. (2014) In press
   PUBMED   25428893
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 22184)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..22184
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="99-4473"
                     /db_xref="taxon:562"
                     /note="serogroup:O184"
     gene            <1..950
                     /gene="gne"
     CDS             <1..950
                     /gene="gnu"
                     /codon_start=3
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 4-epimerase"
                     /protein_id="BAQ02022.1"
                     /db_xref="GI:733167515"
                     /translation="RLLETAIADFNIKNLDKQQSHFYPEITQIGDVRDQQALDQALAG
                     FDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVKNIIFTSSVAVYGLNKH
                     NPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIRPTVIFGERNRGNVYNL
                     LKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGYEVYNYVDKPDLNMNQL
                     VAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAVSSVRVKKFCATTQFDA
                     TKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE"
     gene            1193..2086
                     /gene="galF"
     CDS             1193..2086
                     /gene="galF"
                     /note="O184_01"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ02023.1"
                     /db_xref="GI:733167516"
                     /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEI
                     VAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNV
                     RQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRS
                     QVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDVMAVGRYVLS
                     ADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKY
                     GLRNLQEGAKFRKGIEKLLSE"
     gene            2458..3534
                     /gene="rmlB"
     CDS             2458..3534
                     /gene="rmlB"
                     /note="O184_02"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6 dehydratase"
                     /protein_id="BAQ02024.1"
                     /db_xref="GI:733167517"
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLA
                     DVSDSERYVFEHADICDAAAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARNYWSALDSDKKNSFRFHHISTDEVYGDLPHPDEVNNKERLPLFTETTA
                     YAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KALPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLIICDL
                     LDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTINWY
                     LNNNDWCRRDQDGSYQCERLGLVK"
     gene            3531..4403
                     /gene="rmlA"
     CDS             3531..4403
                     /gene="rmlA"
                     /note="O184_03"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="BAQ02025.1"
                     /db_xref="GI:733167518"
                     /translation="MKGIILAGGSGTRLYPITMGVSKQLLPIYDKPMIYYPLSVLMLA
                     GIQDILIITTPEDQQGFIRLLGDGSQFGINLTYAIQPTPDGLAQAFIIGENFIGNDTV
                     CLVLGDNIFFGQGFTPKLRDAAERTSGATVFGYQVMDPERFGVVEFDRNFKALSIEEK
                     PANPKSNWAVTGLYFYDNNVTDIAKSIKPSKRGELEITAVNEVYLKNNNLTVELLGRG
                     FAWLDTGTHDSLIEAGSFVETVQKRQGLMVACPEEIAWRNGWLNHDELNDKGEFLKKN
                     HYGQYLLRLIKSHE"
     CDS             4396..4803
                     /note="O184_04"
                     /gene="wbaF"
                     /codon_start=1
                     /transl_table=11
                     /product="putative dTDP-6-deoxy-3,4-keto-hexulose
                     isomerase"
                     /protein_id="BAQ02026.1"
                     /db_xref="GI:733167519"
                     /translation="MNNKAKLIQLDKKSDHRGALIVVEQNKDIPIEIKRVYYMFDTGH
                     DVRRGYHAHKTLTQIAIPVKGSCKFLLDDGKTIEHVTLDSPSVGLIIEPLVWHEMYDY
                     SSDCILMVLADDLYDESDYIRDYAEFIREITNE"
     CDS             4796..5329
                     /note="O184_05"
                     /gene="wbaG"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyltransferase"
                     /protein_id="BAQ02027.1"
                     /db_xref="GI:733167520"
                     /translation="MSKLLLSTKNTELIPVEISDAEFIYSLRIDSRLNKHISSINGTI
                     IDQARWIEDYKKREKNNEEFYFIIKRTDNDKKIGTIRLYDITKDNGFCWGSWILNEDK
                     MKSSAIESAYLIYKFGFYHKKYKFSYFQVDKKNKEVIAFHKKTGATIIKEDEVNYHFE
                     FHMENFIKLKEKYSKYI"
     CDS             5342..6445
                     /note="O184_06"
                     /gene="wbaH"
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminotransferase"
                     /protein_id="BAQ02028.1"
                     /db_xref="GI:733167521"
                     /translation="MIDFLNLKRINAQYEMELKDACSRVIDSGWYIMGTELKEFENEF
                     ASWCGVKHTIGVANGLDALILVLRAWKEMGKLNDGDEVIVPANTYIASVLAITENNLV
                     PVLTEPDPLTFNLSASGILKVITGKTKAILPVHLYGQISPMAEIMEIASEFNLLVLED
                     CAQAHGSSINGRKAGCWGHAAGFSFYPGKNLGALGDAGAITTNDDQLADVLRAIRNYG
                     SHEKYKNKYQGLNSRLDEIQAAMLRVKLLHLDRENGLRRKIAHHYLENIKNNNIQLPV
                     VLTEEGHVWHLFVIKTEHRNKLQQHLKNCNIHTLIHYPLPPHKQKAYASYNSISLPIS
                     ESIHNQVISLPMDPNMTEEDILQVIKAVNIFKP"
     gene            6442..7695
                     /gene="wzx"
     CDS             6442..7695
                     /gene="wzx"
                     /note="O184_07"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAQ02029.1"
                     /db_xref="GI:733167522"
                     /translation="MKRLLKVSALSGMLTLLKMLMGFIIAKVIAVYTGPAGMAMLGQI
                     QNIINSFNGIVNSPVSNGVVRFTAENNKSGFYKCSPWWRASLEWLIILCVITIPLGFL
                     FSDYLSTWLFETKEFGWLIKLTVIFLPLTAFGTLISSVINGLENFRRYIILIMVSVLI
                     SSCLMIVMIIYAGLKGALIAAVFQSSMIGAVMLLTNIKQPWFSLTYWWGNTNSKARKD
                     IAGYILMAVTSAITAPLSLILVRNIIIYHSGWEQAGQWQAVWKISEVYLSIITISLST
                     YFLPKLASKADVGGIIQEINKTALIVIPLAIIMAVVVYAGRDIAIYILFTEQFRAARE
                     LFAIQLLGDIVKIISWLYAYPMLSRGATKWYVSTEILFSASFVILSWFLVGEYGNAHG
                     ANVAYLINYTFYFLFIIVNFKKIIK"
     CDS             7721..8950
                     /note="O184_08"
                     /gene="wdcI"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02030.1"
                     /db_xref="GI:733167523"
                     /translation="MQKIIIYHPSKYLGGTEILFSRVIQLLLSVKLLNIHVVDYPDGI
                     LIGKFHNAKVKYHDVINYNTKDVLEGALIISSARNIYRVFYECVKNDVREIKPMFWLL
                     HPSELYAGYCLGSTFLKKISYTVLKRYIAMLPALKFYINVIRELDINKNLWLMDDTSR
                     RESEWMLNYQFRDNAVLPLITNLDCQSISYPVTTQNIKILVISRLDDFKVYGVEKLIT
                     DIIFNKENNNITIEIIGDGEAKNKLIERYNNELNIVFHGYVENAELNRMIENNEYSIL
                     FAMGTSALEGCSRCIPTVLLPCADKSIKGRNNVYKYIHMNDDFSLGEYIDTPFESTGY
                     ITFDDVISTYSKEKYYLREKTKKFFLEKYEKDKTNNDFLNALGQIKSLKITMMKTSLI
                     FEKYTEIIIKQRLKKGF"
     gene            8966..10309
                     /gene="wzy"
     CDS             8966..10309
                     /gene="wzy"
                     /note="O184_09"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAQ02031.1"
                     /db_xref="GI:733167524"
                     /translation="MPIAVYFIEFAYVMIVLLFILYYNSRNMPFIEGLFLILIICSPY
                     SISIIPFRQDMYEIYGIYSNNGILNIVNFYKIAGLSILDMMALLIIVININTVMKIPS
                     FFIMFYFLVGCFSIIGYSISSYLFWSPELDNIFNILSVFKSIIYIISVYCAIDRICKH
                     IGFDKFIKFLANLILCYCIINALILCFLPDWYTWVKYSFNYLFLDQTDQFLVFLYCLL
                     AVWGPLSGIHRYKIYALILCIMLLLSGGKGGVYSLVILAMAWLYKNSNINSAILSICF
                     FLIMILSWMLSYYIGFNVFDLSIYTRYFQVNQLFLNYMNNILTIFFGIGPSKAYFFYS
                     EPAILDPGAYTSSELNSSFKIGFQMPYLTWIKNFGLSGLILLYLSLNYVVKTARHSKS
                     NEAYFSGIVYALGLYFLLVGFMDFPSFGLKTIIPISLYIYIVKMNATNIHCEGRK"
     CDS             10306..11343
                     /note="O184_10"
                     /gene="wdaP"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02032.1"
                     /db_xref="GI:733167525"
                     /translation="MIIIDGIIFSLQKAGGISVYFYELLKYIQKANKEYLHLLYNNQN
                     AYANGNGFIINSKTRLHISIERFRRVPIIGDETDIFHSSYYRLPERSFSGKIITTVHD
                     FTEEMYPRGIVSKIHHIQKRNAILGSDGIICISKNTMMDMHRLIPESIDIPTTVIYNG
                     VGDFKSKECLGEYEPYVIFVGARNGYKNFNMCISALKKINDIRLVVVGGGGFTDNELK
                     LLNTLIPGRYSHAGFITEIELNKLYQNSLALIYPSSYEGFGIPVIEAMKSGCPVIASN
                     SSSVQEISNNAALLIDSICDKKIADAIQSLRNPAFRQEKIKLGIMNATNYSWDKMANE
                     TLSFYNTIRGL"
     gene            11343..12461
                     /gene="gmd"
     CDS             11343..12461
                     /gene="gmd"
                     /note="O184_11"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="BAQ02033.1"
                     /db_xref="GI:733167526"
                     /translation="MKVALITGITGQDGSYLAEFLLNKGYEVHGIKRRTSFFNTTRID
                     HIYQDPHVNNPKLHLHYGDLTDTSNLTRILSEVRPDEVYNLGAMSHVAVSFESPEYTA
                     DVDAIGTLRLLEAIRFLGLEKKSRFYQASTSELYGLVQDVPQKETTPFYPRSPYAVAK
                     LYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAMANISQGIEKCLYLG
                     NMDSLRDWGHAKDYVRMQWMMLQQDQPEDFVIATGKQISVREFVSMSAKEVGLELEFT
                     GKGVDEIATVVNKTSDCAIGVNVGDVIVRVDPRYFRPAEVETLLGDPEKAKKVLGWEP
                     EITVEEMCAEMVASDLAKAKQYALLKSHGYDVSVSLER"
     gene            12465..13430
                     /gene="fcl"
     CDS             12465..13430
                     /gene="fcl"
                     /note="O184_12"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-L-fucose synthetase"
                     /protein_id="BAQ02034.1"
                     /db_xref="GI:733167527"
                     /translation="MIKKRVYVAGHQGMVGSAIYRQLSVREDIELVVKTHKELDLTVQ
                     KDVDAFFEQEKIDQVYLAAAKVGGIYANNTFPAEFIYQNLMIESNIIHAAHKAGVKKL
                     LFLGSSCIYPKFAEQPMNESALLTGILEPTNEPYAIAKIAGIKLCESYNRQYGRDYRS
                     VMPTNLYGINDNFHHENSHVIPALMRRFHEAKESGAPEVIVWGTGTPMREFLYVDDMA
                     AASVHVMELDEEIYQKNTQPMLSHINVGTGVDCSIREMAETMASVVGYQGKIVFDATK
                     PDGTPRKLMDVTRLKNLGWQYRYNLHEGLSLTYKWFIENINSFRG"
     gene            13433..13894
                     /gene="gmm"
     CDS             13433..13894
                     /gene="gmm"
                     /note="O184_13"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosyl hydrolase"
                     /protein_id="BAQ02035.1"
                     /db_xref="GI:733167528"
                     /translation="MNKRLGCDLFKTIVEHTPLISIDLIIRNDKGEALLGQRLNRPAQ
                     NCWFVPGGRIYKDESFEVAFKRITFEELGVQISLNDALFLGVYEHFYDDNFSEAEFST
                     HYVVLGYEIQIKPQQLHLPTVQHNSYKWFDVVTLLNSTIVHQYTKNYFIPR"
     gene            13900..15303
                     /gene="manC"
     CDS             13900..15303
                     /gene="manC"
                     /note="O184_14"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ02036.1"
                     /db_xref="GI:733167529"
                     /translation="MLLPVVMAGGSGTRLWPLSRTLYPKQFLSLNSRLTMLQETLRRL
                     DKVEHKPALVICNESHRFIVAEQLRKEGLKHSGILLEPVGRNTAPAVALSALQAMVTG
                     DDPLLLVLAADHEIQDEDNFIAAVLAAKNFAEQGKLVTFGIVPTSPETGYGYIKSGES
                     LDGQGYKVAAFVEKPDLHVAQRYISNGGYLWNSGMFMFRASVFIDELKKFRPDILASC
                     QSSLSSSIQDLDFIRLDNASFSCCPEESIDYAVMEKTAEAVVVPLNAQWSDVGSWSAL
                     WEISSKDQSGNAIRGDVLVEDATNSYLYSQHRLIGAVGVKDLVVVETKDAVLVAHKDK
                     VQQVKNIVAQLKKNNRTEYLQHREIFRPWGSHDTIAEGPRFQVKHVIVLPGHITAKQI
                     HYHRTEHWIVVSGTAKVHLEDKTYLVSENESTYISVGVPHAIENPGKIPLEIIEVRSG
                     AYLGEDDVTRISNDVGY"
     CDS             15359..16117
                     /note="O184_15"
                     /gene="wdaG"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02037.1"
                     /db_xref="GI:733167530"
                     /translation="MDAHMKVSIITVTYNSEKTIKDTLDSVAVQTYNNIEYIIVDGAS
                     SDATLHIINNSSASVAKCISERDKGIYDALNKGVHLATGDIIGFIHSDDILARPDIIE
                     TIVIEFQKTKADIVYGDLVFVDRSDVNNIVRYWHSGSFRKSKISLGWAPPHPSFYMKR
                     SLYKEDGFFDLTFKIAADYDQMIRVLKRERIKVIYLPQVFVKMRLGGESTKLDNTVAS
                     TKEIISIMKKHHINWYIAIVTRKFSKLTQLFRKS"
     gene            16148..17518
                     /gene="manB"
     CDS             16148..17518
                     /gene="manB"
                     /note="O184_16"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ02038.1"
                     /db_xref="GI:733167531"
                     /translation="MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLG
                     GDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM
                     DYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
                     GYINVKNLTSLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIP
                     NPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE
                     KNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHY
                     FRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEAINR
                     VEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDVPLMEEKTKLI
                     LELLNK"
     gene            17682..19088
                     /gene="gnd"
     CDS             17682..19088
                     /gene="gnd"
                     /note="O184_17"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ02039.1"
                     /db_xref="GI:733167532"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQSAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            19337..20503
                     /gene="ugd"
     CDS             19337..20503
                     /gene="ugd"
                     /note="O184_18"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ02040.1"
                     /db_xref="GI:733167533"
                     /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISP
                     IVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIK
                     DVVEINPYAVMVIKSTVPVGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD"
     gene            20613..21626
                     /gene="wzz"
     CDS             20613..21626
                     /gene="wzz"
                     /note="O184_19"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ02041.1"
                     /db_xref="GI:733167534"
                     /translation="MRTWKFPSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQLWRGKM
                     TIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDGGQIAGYNNAMNVIYGQAAPKVSD
                     LQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKL
                     AQYIQQVDEKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQY
                     ANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDI
                     ENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNY
                     NAK"
BASE COUNT     6712 a   4014 c   4856 g   6602 t
ORIGIN
        1 cccgactact tgaaacggca attgctgact ttaatatcaa gaacctggac aaacagcaga
       61 gccactttta tccagaaatc acacagattg gcgatgttcg tgatcaacag gcgctcgacc
      121 aggcgttagc cggttttgac acagttgtac tactggcagc ggaacaccgc gatgacgtaa
      181 gccctacttc tctctattat gatgtcaacg ttcagggtac ccgcaatgtg ctggcggcca
      241 tggaaaaaaa tggcgttaaa aatatcatct ttaccagttc cgttgctgtt tatggtttga
      301 acaaacacaa ccctgacgaa aaccatccac acgatccttt caaccactac ggcaaaagca
      361 agtggcaggc ggaggaagtg ctgcgtgaat ggtataacaa agcaccaaca gaacgttcat
      421 taaccatcat ccgtcctacc gttatcttcg gtgaacgcaa ccgcggtaat gtctacaact
      481 tgctgaaaca gatcgctggt ggcaagttta tgatggtggg cgcaggaact aactataagt
      541 ccatggcgta tgttggaaac attgttgagt ttatcaagta caaactgaag aatgttgccg
      601 caggttatga ggtttataat tacgttgata agccagatct gaacatgaac cagttggttg
      661 ctgaagttga acaaagtctg aacaaaaaga tcccttctat gcacttgcct tacccactag
      721 gaatgttggg tggatattgc tttgatatcc tgagcaaaat tacgggcaaa aaatacgctg
      781 tcagctctgt gcgcgtgaaa aaattctgcg caacaacaca gtttgacgca acgaaagtgc
      841 attcttcagg ttttgtggca ccgtatacgc tgtcacaagg tctggatcga actctgcagt
      901 atgaattcgt ccatgccaaa aaagacgaca taacgtttgt ttctgagtaa tgcagacgag
      961 tcagagaaaa aaggaccagg ttggactacg attattcgga aagaggtact gattaaatta
     1021 tcagtatgtg gatttccgag taatccgagt aacccagatg ctgatggtgt gtagtgttat
     1081 cgtaaggttt aatcaaagtt atgcggaact aagctttggt atatagccat aacgtttggc
     1141 taacctatgg caataattta ggcactatca gccacttaga ggtaggaaaa taatgacgaa
     1201 tttaaaagca gttataccgg tagcgggtct tgggatgcat atgttgcctg ccactaaggc
     1261 gatacccaaa gagatgctac cgatcgtcga caagccaatg attcagtaca ttgttgacga
     1321 gattgtggct gcagggatca aagaaatcct cctggtaact cacgcgtcca agaacgcggt
     1381 cgaaaaccac ttcgacacct cttatgaatt agaatctctc cttgaacagc gcgtgaagcg
     1441 tcaactgctg gcggaagttc agtccatctg tccaccggga gtgaccatta tgaacgtgcg
     1501 tcagggcgaa cctttaggtt taggccactc cattttgtgt gcgcgacctg ccattggtga
     1561 caacccattt gtcgtggtac tgccagacgt agtgatcgac gacgccagcg ccgacccgct
     1621 gcgctacaac cttgctgcca tgattgcgcg cttcaatgaa acgggacgca gccaggtgct
     1681 ggcaaaacgt atgccgggtg acctctctga atactccgtc attcagacaa aagaaccact
     1741 ggatcgtgaa ggtaaagtca gccgcattgt tgaattcatc gaaaagccgg atcagccgca
     1801 gacgctggac tcagacgtca tggccgttgg tcgctatgtg ctttctgccg atatttggcc
     1861 ggaacttgaa cgtactcagc ctggtgcgtg gggacgtatt cagctgacag atgctattgc
     1921 cgaactggcg aaaaaacagt ccgttgatgc aatgctgatg accggcgaca gttacgactg
     1981 cggtaaaaaa atgggctata tgcaggcgtt tgtgaagtat ggactacgca acctccaaga
     2041 aggggcgaag ttccgtaaag gtattgagaa gctgttaagc gaataatgaa aatctgaccg
     2101 aatgtaacgg ttgataagaa aattataacg gcggtgaaga ttcgtgacga aagtgatttg
     2161 ttgcgaatat tcctgccgtt gttttatata aaccatcaga ataacaacga gttagcaata
     2221 ggattttagt caaagttttc caggattttc cttgtttccg gagcggattg gtaagacaat
     2281 tagcgtttga atttttcggg tttagcgcga gtgggtaacg ctcgtcacat cgtagacatg
     2341 catgcagtgc tctggtagct gtaaagccag gggcggtagc gtgtgttaat acctctatta
     2401 atcaagttaa gagcggctca tttaacagca tgctctgatg taatatggaa taaaaaagtg
     2461 aagatacttg ttactggtgg cgcaggattt attggttctg ctgtagttcg tcacattata
     2521 aataatacgc aggatagtgt tgttaatgtc gataaattaa cgtacgccgg aaacctggaa
     2581 tcacttgctg atgtttctga ttctgaacga tatgtttttg aacatgcgga tatttgcgat
     2641 gctgctgcaa tggcgcggat ttttgctcag catcagccgg atgcagtgat gcacttggct
     2701 gctgaaagcc atgtggatcg ttccattaca ggccctgcgg catttattga aaccaatatt
     2761 gttggtactt atgtcctttt ggaagccgct cgcaattact ggtctgctct tgatagcgac
     2821 aagaaaaata gcttccgttt tcatcatatt tctactgatg aagtctatgg tgatttgcct
     2881 catcctgacg aagtaaataa taaagaaaga ttaccgttat ttactgagac gacagcttac
     2941 gcgccaagta gcccatattc tgcttctaaa gcatccagcg atcatttagt tcgcgcctgg
     3001 aaacgtacct atggtttacc gaccattgtg actaactgtt cgaataacta cggcccttat
     3061 cactttccgg aaaaattgat tccactagta attcttaatg ctctggaagg taaggcatta
     3121 cctatttatg gcaaagggga tcaaattcgt gactggttgt atgttgaaga tcatgcgcgt
     3181 gcgttatata ccgtcgtaac cgaaggtaaa gcgggtgaaa cttataacat tggtggacac
     3241 aatgaaaaga aaaacatcga tgtggtgctc attatttgtg atttgttgga tgagattgta
     3301 ccgaaagaga aatcttaccg cgagcaaatt acttatgttg ccgatcgtcc gggacacgat
     3361 cgccgttatg cgattgatgc tgagaagatt agccgcgaat tgggatggaa accacaggaa
     3421 acgtttgaga gcgggattcg gaagacaatt aactggtatt taaataataa tgattggtgc
     3481 cgacgagatc aagatggctc ttatcaatgt gagcgtttgg ggttagttaa atgaaaggaa
     3541 ttattttagc cggtggttct ggaacaagac tttatccaat tacaatgggg gtttcaaagc
     3601 agctattacc catttatgat aagccgatga tttattatcc attatcggtt ttgatgttag
     3661 caggtataca agatattctt attattacaa cgccagaaga tcagcagggg ttcataagat
     3721 tacttgggga tggaagccaa tttggtatta atctgacata tgcaattcag ccaactccag
     3781 atggtttagc ccaagcattt attattggtg aaaactttat tggaaatgac acagtatgcc
     3841 ttgtgcttgg agataacatc ttttttggac aaggttttac acccaaactt cgggatgcag
     3901 cagaacgaac atcaggtgcc accgtgtttg gatatcaagt aatggatcct gagagatttg
     3961 gagtggtgga gtttgacaga aattttaaag cgttaagtat tgaagaaaaa cctgctaatc
     4021 caaaatcaaa ttgggctgtc acgggattat atttttatga caataacgta accgatattg
     4081 caaagagtat taaaccatct aaacgcggtg aattagaaat tactgcagtt aatgaagttt
     4141 atctaaaaaa taataattta actgttgaat tactaggacg tggttttgca tggctggata
     4201 caggcaccca tgacagtttg attgaagctg gcagttttgt agagacagtt caaaaaaggc
     4261 aagggttgat ggtagcatgt ccggaagaga tagcatggcg aaatggctgg ttaaaccatg
     4321 atgaattaaa tgataaagga gagtttttga aaaaaaatca ctacggacaa tatttactca
     4381 ggttaatcaa atcgcatgaa taataaagca aagcttatac agctagataa gaaaagtgac
     4441 caccgaggcg ctcttattgt tgtcgagcaa aataaagata ttccaattga aattaaacga
     4501 gtttactaca tgtttgatac aggacatgat gtaaggcggg gatatcatgc acataaaaca
     4561 cttacacaaa tagcaatacc tgttaaagga tcttgcaagt ttttgcttga tgacggtaag
     4621 acgatagagc atgttacatt agattcacct tcagtcggat taattataga gccgttggtt
     4681 tggcatgaaa tgtacgatta ttcatcagat tgtattttaa tggtgttggc tgatgactta
     4741 tacgatgaaa gtgattatat tcgtgattat gctgaattta taagggagat aactaatgag
     4801 taaattgttg ctttccacaa aaaacacaga attaattcca gttgaaataa gtgatgcaga
     4861 atttatttat tcacttcgca ttgattctcg tctcaataag catatttctt caattaatgg
     4921 gacgattatt gatcaggcta gatggattga ggattataag aaaagagaaa aaaataatga
     4981 ggagttttat tttatcataa agagaactga taatgataaa aaaattggta caataagact
     5041 gtatgacatt acgaaagata atggtttctg ttgggggagt tggattttaa atgaagataa
     5101 aatgaaaagt tctgcaatag aaagcgcgta tctaatatac aaatttggtt tttatcataa
     5161 aaaatataaa ttttcctatt ttcaagttga taaaaaaaat aaagaagtaa tagcatttca
     5221 taaaaaaaca ggggctacga taatcaaaga ggatgaagtg aattatcact ttgaattcca
     5281 tatggaaaac tttattaaat taaaagaaaa gtatagtaaa tatatttaag agggacagct
     5341 aatgattgac tttttaaatt tgaaaagaat aaacgcacaa tatgaaatgg aattaaaaga
     5401 tgcctgctcc agagttattg attctggttg gtatataatg gggactgaat taaaagaatt
     5461 tgagaacgaa tttgcaagtt ggtgtggagt aaagcacact attggtgttg ctaacggttt
     5521 agatgcactt atacttgttc ttcgagcctg gaaggaaatg ggaaaattaa atgatggaga
     5581 tgaagttatt gtacctgcca atacatatat tgcgtcagta ttagcaataa ctgaaaataa
     5641 tctggtgcct gtattaactg agccagatcc tttaacattt aacttaagtg caagcgggat
     5701 tcttaaagta atcacaggta aaacaaaagc gattttgcca gtacacttgt atggacaaat
     5761 atctccaatg gcagaaataa tggagattgc ctcagagttt aatttattag ttttagagga
     5821 ttgcgctcaa gctcatggct cctcaatcaa tggacgcaaa gctggctgtt ggggtcatgc
     5881 agcaggattc agcttctatc cgggaaaaaa tcttggcgct ttaggtgatg ctggtgcgat
     5941 aacaacaaat gatgatcaac ttgcagacgt tttgagagct attagaaatt atggctctca
     6001 tgaaaaatat aaaaataaat atcaaggtct aaatagtcgt ttggatgaaa tccaagcggc
     6061 aatgctgaga gttaaattat tacatttgga tagagagaat ggactcagaa gaaaaattgc
     6121 acatcattac ctggagaata taaaaaataa taatatacaa ttacctgttg tattaacaga
     6181 agaaggtcat gtatggcatt tgtttgtaat aaagacagag cataggaata aattacagca
     6241 gcacttaaaa aattgtaata tacatactct tattcattac ccactaccac ctcataaaca
     6301 aaaggcatac gcttcctata atagtataag tttgccgatt tctgaatcaa tccataacca
     6361 agtcatttca cttcccatgg atccaaacat gactgaagag gatattctgc aggttattaa
     6421 agcggttaac atttttaaac catgaaacgg ttattaaaag tcagtgcgct aagtgggatg
     6481 ttaacattac tgaaaatgtt aatggggttt ataattgcga aagtaattgc ggtttatacc
     6541 ggaccagctg gaatggcaat gcttggtcaa atccaaaata ttatcaacag ttttaatggt
     6601 attgttaatt caccagtcag taatggcgtt gtgaggttta ctgctgaaaa caataaatca
     6661 ggattttata aatgctctcc gtggtggaga gcttcattag aatggctaat tatactctgt
     6721 gtgataacta ttcctttagg atttttattt tcagattatc tttcaacatg gctgtttgaa
     6781 acaaaagaat ttggttggct tataaagcta acggttatat ttctcccttt aacagcattc
     6841 ggtacgctaa tatcatcagt gattaacggt ttggagaact ttcgccgata cattatttta
     6901 ataatggtgt ctgtcctcat atccagttgt ctgatgattg taatgatcat atatgcaggg
     6961 ttaaaaggag cattaattgc agctgtattc cagtcatcaa tgattggtgc tgtaatgctt
     7021 cttactaaca tcaaacaacc atggttttca ttaacctatt ggtggggaaa tacaaacagt
     7081 aaagcaagaa aagatatagc tggttatata ttaatggcag tgacatcagc tattactgct
     7141 ccattatcac tgattttagt acgtaacatt attatctatc attcaggctg ggaacaagct
     7201 ggtcagtggc aggcagtttg gaaaatatca gaggtttatt taagtataat aacaatttcg
     7261 ttaagtactt attttctacc aaaacttgca tcaaaagctg atgtaggggg tattattcag
     7321 gaaataaaca agactgctct aatagttatc cctttagcca ttattatggc cgtagttgtg
     7381 tatgctggta gggatattgc aatttatatt ttatttactg agcaatttag agcggctaga
     7441 gaactttttg cgattcagct tcttggtgat attgttaaaa taataagttg gctttatgcc
     7501 tatccaatgt tgtctcgtgg tgcaacaaaa tggtatgtgt ctactgaaat attattttca
     7561 gcttcttttg ttattttatc atggttctta gtaggtgagt atggaaatgc tcatggggca
     7621 aatgtcgcat acctgataaa ttacactttc tattttttat ttataattgt taactttaaa
     7681 aaaatcatta aatagtatag atataaatcc aggagaactt atgcaaaaaa taataatata
     7741 tcatcctagt aaatatttag ggggcacaga gattcttttt tcacgggtca tccaattgtt
     7801 attatccgta aaacttttaa atattcatgt tgttgattat cctgatggca ttttaatagg
     7861 taagttccac aacgcaaaag taaaatatca tgatgttatc aattataata caaaagatgt
     7921 tctggaagga gcattaatta tttctagcgc taggaatata tacagggtat tctatgaatg
     7981 tgttaagaat gatgttagag aaataaaacc tatgttttgg cttttgcatc catcagaatt
     8041 atatgctggt tattgtttag gtagtacttt tctaaaaaaa ataagttata cagtacttaa
     8101 aagatatata gctatgctac cagctttgaa gttttatata aatgtgatta gagaattaga
     8161 tattaacaaa aatctttggt taatggatga tacaagcaga cgtgaaagtg agtggatgct
     8221 aaattaccaa tttcgagata atgcagtact tccgctcatt acaaatctcg attgccagtc
     8281 catatcatat cctgttacaa ctcaaaatat taaaatattg gtgataagtc gtctggatga
     8341 tttcaaggta tatggggttg aaaaattaat aacagatatt atctttaata aagaaaataa
     8401 taacatcact atagaaatta taggtgatgg tgaagctaaa aataaattaa ttgaacgtta
     8461 taataatgag ctcaatatag tttttcatgg ctatgtagag aatgcggaac ttaatcgcat
     8521 gattgaaaat aatgaatatt caattttatt tgctatggga acttctgctt tagaaggatg
     8581 ttcaagatgt ataccaacag ttttattacc ttgtgcggac aaatctatta agggcagaaa
     8641 caacgtgtat aaatatattc atatgaatga cgatttctcg ctgggtgaat atattgatac
     8701 tcctttcgaa agtactggtt atataacatt cgatgatgtt atttcaactt atagcaaaga
     8761 gaaatattat ttacgggaaa aaacaaaaaa atttttttta gaaaagtatg aaaaagataa
     8821 gaccaataat gactttttga atgcattagg acaaattaaa tcattaaaaa taaccatgat
     8881 gaaaacttcg cttatctttg aaaaatatac ggaaatcatc ataaagcaaa gattaaaaaa
     8941 agggttttaa attaggaata aaaaaatgcc tattgctgta tattttattg aatttgctta
     9001 tgtaatgata gtgttattgt ttattcttta ctataatagc agaaatatgc cgtttatcga
     9061 aggtctgttt ttgatattga tcatatgctc accttattcg atctctataa ttccattcag
     9121 acaagatatg tatgaaattt atggaattta tagtaataat ggcattttga atattgtcaa
     9181 tttttataag atcgctggtt tatctatact tgatatgatg gcattgttaa ttatagtgat
     9241 taatattaat actgtcatga aaatcccttc attttttata atgttctatt ttttagtagg
     9301 gtgtttttca ataatcggtt attctatctc atcttatcta ttctggtcac cagagcttga
     9361 taatattttc aatattcttt ctgtcttcaa atcaataata tatataatta gtgtttattg
     9421 tgctattgat cgaatttgta aacatattgg ttttgacaag tttattaaat ttcttgcgaa
     9481 tttaatattg tgctactgta ttatcaatgc attaatactt tgcttccttc ctgattggta
     9541 tacatgggtc aagtattcat tcaattattt atttctcgat caaacagatc agtttctggt
     9601 ttttctttat tgtttgctgg cagtttgggg gccattgagt ggtattcatc gatataaaat
     9661 atatgctttg attttatgta ttatgctttt attaagtgga ggaaaggggg gggtttattc
     9721 attagtaatt ttggcaatgg catggttata taaaaattca aatattaaca gcgctatcct
     9781 atcaatatgc ttctttctta taatgatatt atcatggatg ctttcttatt atatagggtt
     9841 taacgtattc gatttgtcta tctatacacg ttacttccaa gttaaccagc tttttttaaa
     9901 ttacatgaat aatatcctta ctattttctt tggcattggg ccctcaaagg catatttttt
     9961 ctatagtgaa cctgcaatat tagatccagg agcatataca tctagtgagt tgaattctag
    10021 ttttaaaatt ggatttcaaa tgccatattt aacatggata aaaaactttg gtctatcagg
    10081 attgatcctt ttatatttat cactcaatta tgttgtaaaa acagctaggc attcaaaatc
    10141 gaatgaagca tatttttctg ggattgttta tgcgctaggg ttatattttt tattggtcgg
    10201 cttcatggac tttccatcat ttggtttaaa gactataatt ccaattagtt tatatattta
    10261 tattgtcaaa atgaatgcta caaatatcca ttgtgagggc aggaaatgat tattatcgat
    10321 ggaataattt tttctttaca aaaagctggt ggaatatccg tatattttta tgagttgctg
    10381 aaatatatcc agaaagccaa taaagagtat ctgcatctgc tatataataa tcaaaatgcc
    10441 tatgcaaatg gaaatggttt tataattaat agtaagacta gattacatat ttcaatcgaa
    10501 agatttagaa gggttccaat tattggtgat gaaacagata tttttcattc aagttactac
    10561 agattaccag agagaagttt ttctggaaaa ataataacta cggttcatga ttttacagaa
    10621 gagatgtatc caagaggcat tgtttctaag attcatcata ttcaaaaaag aaatgcgata
    10681 ttaggcagtg atggaataat atgtatatcc aaaaacacaa tgatggatat gcacagacta
    10741 attcctgaat ctatcgatat tccgacgaca gtaatttata acggtgttgg ggattttaaa
    10801 agcaaggagt gcttggggga atatgaacca tatgtgattt ttgtgggggc taggaatgga
    10861 tataaaaact ttaatatgtg catatctgcg cttaaaaaaa taaatgatat tcggttagta
    10921 gttgttggtg gaggtggatt tacggataat gaattaaaat tgctgaatac tcttattccc
    10981 ggacgttact cacatgcagg ttttataact gaaattgaac ttaataaact ttatcagaat
    11041 tcgttggcat tgatatatcc ttcgtcatat gaagggtttg gaattccagt tattgaagca
    11101 atgaaatcag gttgtccagt tattgcatct aattcttctt cagttcaaga aatatctaat
    11161 aacgctgctt tattaattga tagtatttgt gacaaaaaaa tagcagatgc tattcaaagc
    11221 ttaaggaatc cagcttttag gcaagagaaa ataaaattag gaatcatgaa tgccacgaat
    11281 tactcctggg ataagatggc aaatgaaaca ttgagttttt acaatactat acgaggttta
    11341 taatgaaagt agcattgatt acaggtatta ctggacaaga tggctcatat ctggctgaat
    11401 ttttattaaa taaaggttat gaagtgcacg gtatcaaacg ccgtacatca ttttttaata
    11461 ccacacgaat cgaccatata tatcaagatc cccatgtaaa taatccaaaa ttgcatcttc
    11521 actatggtga tttaactgat acgtctaatt taacacgtat tttatcagag gtgcgtccag
    11581 atgaagtata caacctagga gcaatgagtc atgtggctgt atcgtttgaa tcgccagagt
    11641 atacagctga tgtggatgct ataggaactt tgcgcttatt agaggctatt cgttttttgg
    11701 gattggaaaa gaagagtcgt ttttatcagg cgtcaacatc tgaattgtat gggttggtcc
    11761 aggatgttcc acaaaaagag acaacgcctt tctatcctcg ctctccttat gcggtagcca
    11821 aactatatgc ttattggatc actgtcaact atcgtgagtc ctatggaatg tatgcatgta
    11881 acggtatttt gttcaaccat gaatccccac gtcgtgggga aacgtttgta acgcgtaaga
    11941 tcacacgtgc aatggctaat atttctcagg gaatagagaa atgcctctat cttggaaata
    12001 tggattcact gcgtgattgg ggacatgcta aagattatgt gcgtatgcaa tggatgatgc
    12061 ttcagcaaga tcaaccagaa gattttgtga ttgccacggg caaacaaatt tctgtacgtg
    12121 aatttgtcag tatgtcagct aaagaagttg gtctggaatt agaattcact ggtaaaggtg
    12181 tagatgaaat agcaaccgtt gttaataaaa catctgactg tgctattggt gtaaatgtag
    12241 gagacgtaat cgttcgcgtt gatcctcgtt atttccgtcc tgctgaagtt gaaactcttc
    12301 ttggtgatcc agaaaaagcg aaaaaagtat taggttggga accagagatt acagtcgaag
    12361 aaatgtgtgc agaaatggtt gccagtgatc tggcgaaagc aaaacagtat gcactactta
    12421 aaagccatgg ttatgatgtt tcggtttctc tggagcgtta atacatgata aagaaaagag
    12481 tttatgttgc tgggcatcag ggcatggtcg gctccgctat ttaccgacaa ttatcggttc
    12541 gtgaagatat cgaattagtg gttaaaacac acaaagaact cgatctaact gtccagaagg
    12601 atgttgatgc attttttgag caagagaaaa ttgatcaggt ttatcttgct gcggctaaag
    12661 ttggtggcat ttatgccaat aacacatttc cggcagaatt catctatcag aatctcatga
    12721 ttgagagtaa tattattcat gcagctcaca aagccggagt taaaaaatta ctttttttag
    12781 gctcaagctg tatttatcct aaatttgcag agcagccgat gaatgagtct gcgcttttaa
    12841 ctggcatact tgagccaact aatgagccat acgcaattgc taaaattgcg ggcataaaat
    12901 tatgtgaatc ttataaccgt caatatggcc gtgattatcg cagtgtaatg cctactaatc
    12961 tttatggcat aaatgataat tttcaccatg aaaactctca tgttattccg gcactcatgc
    13021 gtagattcca tgaagcaaaa gagagtggtg caccagaggt tattgtctgg ggaaccggaa
    13081 caccgatgcg tgagttttta tatgttgatg atatggctgc cgcatctgtt catgtaatgg
    13141 aactcgacga agaaatttat caaaaaaata cacagcctat gttatctcat attaatgttg
    13201 gtacgggtgt ggattgttct atacgtgaaa tggctgaaac aatggcctct gtggtgggtt
    13261 atcaaggtaa aattgttttt gatgctacca aacctgatgg cactccgcgt aaacttatgg
    13321 atgttacccg gctcaaaaac ttgggttggc aatatcgcta taatttacat gaaggcttat
    13381 cattaacata taaatggttt attgagaata ttaattcttt tcggggatag ttatgaacaa
    13441 gagattggga tgtgacttat ttaaaacaat agttgagcat actcctctaa tctcgattga
    13501 tctcataatt agaaacgata aaggagaggc gctgctggga cagcgcctga atcgcccagc
    13561 acaaaattgt tggtttgtgc caggtgggcg aatttataag gatgagtcat tcgaggttgc
    13621 atttaaacgg ataacatttg aagagttggg cgttcaaatt agtcttaatg atgccttatt
    13681 tcttggagtg tatgaacatt tttacgatga taatttttct gaagcggaat tttctacaca
    13741 ctacgtagtg cttggatatg aaatccaaat taaaccgcag caacttcacc taccaacggt
    13801 ccaacacaat tcttacaaat ggtttgatgt agtaacgttg ctgaatagca ctatagttca
    13861 tcaatatacc aaaaattatt ttataccaag gtaatagata tgctacttcc tgttgttatg
    13921 gccggtggtt ccggtaccag attatggcct ctttcacgta cactttatcc gaaacaattt
    13981 ctgtctttaa atagtcgttt aaccatgttg caagagacat tgcggcggct tgacaaggtc
    14041 gaacataaac ccgctttggt catttgtaac gaatcacatc gctttatcgt tgctgaacaa
    14101 ttgcgtaaag aaggtttaaa gcatagtggt attttgctcg agcctgttgg tcgtaatact
    14161 gcgcctgctg tagcactttc agcacttcag gctatggtaa ctggagatga tcctcttctg
    14221 ttggttcttg ctgctgatca tgaaatccag gatgaggata atttcattgc tgcagttctt
    14281 gctgccaaga attttgcaga gcagggtaag cttgttacgt ttggtattgt tccaacatcc
    14341 cctgagactg gctatggtta cattaagtca ggtgaatctc tggatggaca aggttacaaa
    14401 gttgcagctt ttgttgaaaa accagatctt cacgtagctc agcggtacat atcaaatggc
    14461 ggttatcttt ggaatagtgg gatgtttatg ttcagagcat ctgtatttat cgatgaactg
    14521 aaaaaattcc gaccagatat tttagccagt tgccaaagct ccctgtcttc ttcgatacaa
    14581 gatttagatt ttatccgcct ggataacgct tcattttctt gctgtcctga agagtctatt
    14641 gactatgccg ttatggaaaa aacagccgaa gctgtcgtcg ttccattaaa tgcgcaatgg
    14701 agtgatgtcg ggtcatggtc tgcattgtgg gaaataagtt caaaagacca aagcggcaat
    14761 gccattcgtg gtgatgtatt agttgaagat gctacaaata gttatcttta ttcacagcat
    14821 agacttattg gtgccgttgg cgtaaaggat ttggttgttg ttgaaacgaa agatgcagtg
    14881 ttagttgctc ataaagataa agttcagcaa gttaaaaaca tcgtcgctca acttaaaaag
    14941 aataatcgaa cagaatattt acagcatcgg gaaatttttc gaccttgggg cagtcatgat
    15001 actatagctg aagggccgcg ctttcaggtg aaacatgtga ttgtattacc tggtcacatt
    15061 accgctaaac agattcatta ccatcgtact gagcattgga ttgttgtctc gggaacagct
    15121 aaagttcatc ttgaagataa gacttacctt gtttctgaaa atgaatcaac atatatatct
    15181 gttggtgttc cacatgccat tgaaaacccg ggaaaaatac ctttagaaat tattgaggtg
    15241 cggtctgggg catatttagg tgaagatgat gtcaccagga tatctaatga tgttggctat
    15301 tgaaatattg gggaataacc ggctactgca ataaaatacc tcgaaaacta atttcacatt
    15361 ggatgcgcat atgaaagtca gtattattac cgtgacttat aacagcgaga aaacaattaa
    15421 agacacttta gattcggttg ctgtgcagac atataataat attgagtata ttattgttga
    15481 tggtgcttct tctgatgcaa cgttgcacat tattaataac tcttcagctt cagtcgccaa
    15541 atgcatttcg gaaagagata agggtatcta tgatgcactt aataaaggtg tacatttagc
    15601 aacaggtgat ataattggat ttattcactc tgacgatata ttggcgaggc cagacattat
    15661 agaaacaatt gttattgagt ttcagaaaac aaaagctgat attgtttatg gtgatctggt
    15721 tttcgttgat aggagcgatg tcaataacat tgtaagatac tggcatagtg gttcttttag
    15781 aaaaagtaaa atatctttag gatgggcgcc tccacatcct tctttttata tgaagagaag
    15841 tttatataag gaagacggtt tttttgattt gacctttaaa atcgctgctg attacgatca
    15901 gatgattcga gttctgaaaa gagagcgtat taaggttatt taccttcctc aagtcttcgt
    15961 taaaatgaga ttggggggag agagcacgaa acttgataat acagtagcta gtacaaaaga
    16021 aattatctct ataatgaaaa aacatcatat aaattggtat attgcgatcg ttactagaaa
    16081 attttctaaa ttgactcaac tcttcagaaa atcataatca tatctatatg catggaatgt
    16141 atatttaatg aaaaaattaa cctgctttaa agcctatgat attcgcggga aattaggcga
    16201 agaactgaat gaagatattg cgtggcgcat tggtcgcgcc tatggcgaat ttctcaaacc
    16261 gaaaaccatt gtgttaggcg gtgatgtccg cctcaccagc gaaaccttaa aactggcgtt
    16321 ggcaaaaggt ttacaggatg cgggcgtcga tgtgctggat atcggcatgt ccggcaccga
    16381 agagatttat ttcgccacgt tccatctcgg cgtggatggc ggcatcgaag ttaccgccag
    16441 ccataatccg atggattata acggcatgaa actggtgcgc gaaggggctc gcccgatcag
    16501 cggtgatacc ggactgcgcg atgtccagcg tctggcagaa gccaacgact tccctcccgt
    16561 tgatgaaacc aaacgcggtc gctatcagca aatcaatctg cgtgacgctt acgttgatca
    16621 cctgttcggt tatatcaacg tcaaaaacct cacgtcgctc aagctggtga tcaactccgg
    16681 gaacggcgcg gcgggtccgg tggtggacgc cattgaagcc cgatttaaag ccctcggcgc
    16741 accggtggaa ttaatcaaag tacacaacac gccggacggc aatttcccca acggtattcc
    16801 taacccgcta ctgccggaat gccgcgacga cacccgcaat gcggtcatca aacacggtgc
    16861 ggatatgggc attgcttttg atggcgattt tgaccgctgc ttcctgtttg acgaaaaagg
    16921 gcagtttatt gagggctact acattgtcgg cctgctggca gaagcgttcc tcgaaaaaaa
    16981 tcccggcgcg aagatcatcc acgatccacg tctctcctgg aacaccgttg atgtggtgac
    17041 cgccgcgggc ggcacgccgg tgatgtcgaa aaccggacac gcctttatta aagaacgtat
    17101 gcgcaaggaa gacgccatct acggtggcga aatgagcgcc caccattact tccgtgattt
    17161 cgcctactgc gacagcggca tgatcccgtg gctgctggtc gccgaactgg tgtgtctgaa
    17221 aggaaaaacg ctgggtgaac tggtgcgcga ccggatggcg gcgttcccgg caagcggtga
    17281 gatcaacagc aaactggcgc aacccgttga ggcgattaac cgcgtggaac agcattttag
    17341 ccgtgaggcg ctggcggtgg atcgcaccga tggcatcagc atgacctttg ccgactggcg
    17401 ctttaacctg cgctcctcca acaccgaacc ggtggtgcgc ctgaatgtgg aatcgcgcgg
    17461 tgatgtgccg ctgatggaag aaaagacaaa acttatcctt gagttactga ataagtaatt
    17521 gagtaaattc atataaatag gttttaaaag acagaaaaga tgagatattc agtgtggtat
    17581 agcaaaggta atgctattca ccatctctat gagtgagtta acatctatac cacatttaag
    17641 ccgcacactc ggcggtgacc accccctgac aggagtaaac aatgtcaaag caacagatcg
    17701 gcgtagtcgg tatggcagtg atggggcgca accttgcgct caacatcgaa agccgtggtt
    17761 ataccgtctc tattttcaac cgttcccgtg aaaagacgga agaagtgatt gccgaaaatc
    17821 caggcaagaa actggttcct tactatacgg tgaaagagtt tgttgaatct ctggaaacgc
    17881 ctcgtcgcat cctgttaatg gtgaaagcag gtgctggcac ggatgctgct attgattccc
    17941 tcaaaccata cctcgataaa ggtgacatca tcattgatgg tggtaacacc ttcttccagg
    18001 acaccattcg tcgtaaccgt gagctttctg ccgaaggttt taactttatc ggtaccggtg
    18061 tttccggtgg tgaagaaggc gcgctgaaag gtccttccat tatgcctggt gggcagaaag
    18121 atgcctatga actggttgct ccgatcctga ccaaaatcgc cgccgttgct gaagatggcg
    18181 aaccgtgcgt tacctatatc ggtgctgatg gcgcaggcca ttatgtgaag atggttcaca
    18241 acggtattga atacggtgat atgcaactga ttgctgaagc ctattctctg ctgaaaggtg
    18301 gtctgaatct ctctaacgaa gaactggcac agacctttac cgagtggaat aacggtgaac
    18361 tgagcagcta cctgatcgac atcaccaaag acatcttcac taaaaaagat gaagacggta
    18421 actacctggt tgatgtgatc ctggatgaag cggctaacaa aggtaccggt aaatggacca
    18481 gccagagcgc gctggatctc ggagaaccgc tgtcgctgat taccgagtct gtgtttgcac
    18541 gttatatctc ttctctgaaa gatcagcgcg ttgccgcatc taaagttctc tctggtccgc
    18601 aagctcagtc agcaggcgac aaggctgagt tcatcgaaaa agttcgccgt gcgctgtatc
    18661 tgggcaaaat cgtttcttac gctcagggct tctctcagct gcgtgctgcg tctgaagaat
    18721 acaactggga tctgaactac ggcgaaatcg cgaagatttt ccgtgctggc tgcatcatcc
    18781 gtgcgcagtt cctgcagaaa attaccgatg cgtatgccga aaatccgcag atcgctaacc
    18841 tgctgctggc tccgtacttc aagcaaattg ccgatgacta tcagcaggcg ctgcgtgatg
    18901 tcgttgctta tgcggtacag aacggtatcc cggttccgac cttcgctgct gcggttgcct
    18961 attacgatag ctaccgtgcc gctgttctgc ctgcgaacct gatccaggca cagcgtgact
    19021 atttcggtgc gcatacttat aagcgcattg ataaagaagg tgtgttccat actgaatggc
    19081 tggattaatc tgatttaacc aacaataaaa ttgaggcctg gcgtatattg cgccgggctt
    19141 ttttttgcca attatcttat ggactaaatt tcactgctta atattaactt aataaatatc
    19201 agctattctt ataaagaaaa tctgaattgt ttttcgttgc gttgaccatc gaacaacgta
    19261 gcgttaaaac ttttagctct tatcaggatg ctaaaaacat catgattcac agttaagtta
    19321 attctgagag catgaaatga aaatcaccat ttccggtact ggctatgtag gcttgtcaaa
    19381 cgggcttcta atcgcacaaa atcatgaggt tgtggcatta gatattttac cgtcacgcgt
    19441 tgctatgctg aatgatcgga tatctcctat tgttgataag gaaattcagc agtttttgca
    19501 atcagataaa atacacttta atgccacatt agataaaaat gaagcctacc gggatgctga
    19561 ttatgtcatc atcgccactc caaccgacta tgatcctaaa actaattatt tcaatacatc
    19621 cagtgtagaa tcagtaatta aagacgtagt tgagataaat ccttatgcgg ttatggtcat
    19681 caaatcaacg gttcccgttg gttttaccga agcgatgcat aagaaatatc gtactgaaaa
    19741 tattattttc tctccggaat ttctccgtga aggtaaagcc ctttacgata atctccatcc
    19801 gtcacgtatt gtcatcggtg agcgttcaga acgcgcagaa cgttttgctg cgttgttaca
    19861 ggaaggcgcg attaagcaaa atatcccgac cctgtttacc gactccactg aagcagaagc
    19921 gattaaactt tttgcaaaca cctacctggc gatgcgcgtg gcgtacttta acgaactgga
    19981 tagctacgca gaaagtttag gtctgaatac tcgccagatt atcgaaggcg tttgtctcga
    20041 tccgcgtatt ggcaaccatt acaacaaccc gtcgtttggt tatggtggtt attgcttgcc
    20101 gaaagatacc aagcagttac tggcgaacta tcagtctgtg ccgaataacc tgatctcggc
    20161 aattgtcgat gcaaaccgca cgcgtaagga ttttattgcc gatgccattt tgtcacgcaa
    20221 accgcaagtg gtgggtattt atcgtctgat tatgaagagc ggttcagata acttccgtgc
    20281 gtcttctatt caggggatta tgaagcgtat caaggcgaaa ggcgttgaag tgatcatcta
    20341 cgagccagtg atgaaagaag actcattctt caactctcgc ctggaacgtg atctcgccac
    20401 cttcaaacaa caagccgacg tcattatttc caaccgtatg gcagaagagc ttagggatgt
    20461 ggcagataag gtctacaccc gcgatctctt tggcagcgac taacatcttg ttatcagggc
    20521 tatttacgcc ctgattgtct tttgttactt acgcaacaat tcattatttt tatcacttat
    20581 cctatagcat tcacggggat tatcgctaaa ctatgcggac ttggaaattt ccgtcagtta
    20641 gggtaatgat gagagtagaa aataataatg tttctgggca aaaccatgac ccggaacaga
    20701 ttgatttgat tgatttacta gtgcagttgt ggcgtggcaa gatgacaatc atcatttccg
    20761 tcattgtagc tattgccctg gctattggtt atttggcagt agcgaaggag aaatggacgt
    20821 caacagcaat tatcactcag cccgacgggg ggcaaattgc tggctataac aatgccatga
    20881 atgttatata tggtcaggct gcaccgaaag tatcggattt gcaggagacg ttaattggtc
    20941 gcttcagttc tgccttctct gcattagcag aaacgctgga taatcaggaa gagccagaga
    21001 aacttaccat cgaaccttct gttaagaacc agcaattacc attgactgtt tcttatgttg
    21061 ggcaaacagc agagggcgca caaatgaagt tggcccaata cattcagcaa gttgatgaaa
    21121 aagtgaatca agagctagaa aaggatctca aagacaacat tgctttggga cggaaaaact
    21181 tgcaggactc tttaagaact caggaagtag tcgcgcagga gcagaaagat ctgcgtatcc
    21241 gtcagattca ggaagcattg cagtatgcga atcaggcgca ggtgacaaaa ccacaggttc
    21301 agcagactga agatgtgacg caagatacgt tgttcctttt ggggagcgaa gcgctggagt
    21361 cgatgattaa gcatgaggcg acccgtccgt tggtgttctc accaaactac tatcagactc
    21421 gtcaaaacct gctggatatc gaaaacttaa aggttgatga tcttgatatc catgcttacc
    21481 gctatgtgat gaaaccgacg ttacctattc gtcgcgatag cccgaaaaag gcaattacct
    21541 tgattctggc agtcctgctg ggcggcatgg ttggcgcggg gattgtgctg gggcgtaacg
    21601 ctctacgcaa ttacaacgcg aaataggtaa tgactccaac ttattgatag tgttttatgt
    21661 tcagataatg cccgatgact ttgtcatgca gctccaccga ttttgagaac gacagcgact
    21721 tccgtcccag ccgtgccagg tgctgcctca gattcaggtt atgccgctca attcgctgcg
    21781 tatatcgctt gctgattacg tgcagctttc ccttcaggcg ggattcatac agcggccagc
    21841 catccgtcat ccatatcacc acgtcaaagg gtgacagcag gctcataaga cgccccagcg
    21901 tcgccatagt gcgttcaccg aatacgtgcg caacaaccgt cttccggagc ctgtcatacg
    21961 cgtaaaacag ccagcgctgg cgcgatttag ccccgacgta tccccactgt tcgtccattt
    22021 ccgcgcagac gatgacgtca ctgcccggct gtatgcgcga ggttaccgac tgcggcctga
    22081 gttttttaaa tggcggaaaa tcgtgttgag gccaacgccc ataatgcggg cggttgcccg
    22141 gcatccaacg ccattcatgg ccatatcaat gattttctgg tgcg
//
