LOCUS       AB812083               22170 bp    DNA     linear   BCT 13-DEC-2014
DEFINITION  Escherichia coli genes for O-antigen biosynthetic locus, partial
            sequence, strain: 559-59.
ACCESSION   AB812083
VERSION     AB812083.1  GI:733167574
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. (2014) In press
   PUBMED   25428893
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 22170)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..22170
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="559-59"
                     /db_xref="taxon:562"
                     /note="serogroup:O187"
     gene            <1..909
                     /gene="wcaM"
     CDS             <1..909
                     /gene="wcaM"
                     /codon_start=1
                     /transl_table=11
                     /product="colanic acid biosynthesis protein"
                     /protein_id="BAQ02079.1"
                     /db_xref="GI:733167575"
                     /translation="ANYAILRQGFHNQIIGANITNCKFSDLQGDAIEWNVAINDSDIL
                     ISDHVIERINCTNGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHV
                     ENGKHFVIRNIKACNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGV
                     IKGKYLSIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHN
                     KPQHLFMRNIKVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNESGQS
                     SVDIDRINHHIVNVEKINFRLPERRE"
     gene            1072..1977
                     /gene="galF"
     CDS             1072..1977
                     /gene="galF"
                     /note="O187_01"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ02080.1"
                     /db_xref="GI:733167576"
                     /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYI
                     VDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVT
                     IMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNE
                     TGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGR
                     YVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQA
                     FVKYGLRNLKEGAKFRKGIEKLLSE"
     gene            2350..3426
                     /gene="rmlB"
     CDS             2350..3426
                     /gene="rmlB"
                     /note="O187_02"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6 dehydratase"
                     /protein_id="BAQ02081.1"
                     /db_xref="GI:733167577"
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLA
                     DVSDSERYVFEHADICDAAAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARNYWSALDGDKKNSFRFHHISTDEVYGDLPHPDEVNNKEQLPLFTETTA
                     YAPSSPYSASKASSDHLARAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KALPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDL
                     LDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTINWY
                     LNNNDWCRRVQDGSYQRERLGVIR"
     gene            3423..4286
                     /gene="rmlA"
     CDS             3423..4286
                     /gene="rmlA"
                     /note="O187_03"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="BAQ02082.1"
                     /db_xref="GI:733167578"
                     /translation="MKGIILAGGSGTRLYPITMGVSKQLLPIYDKPMIYYPLSVLMLA
                     GIQDILIITTPEDQQGFIRLLGNGSQFGINLNYATQRNPDGLAQAFIIGEQFIGEDSV
                     CLVLGDNIFFGQGFTPKLRCAAEREIGATIFGYQVMDPERFGVVEFDCNYKALSIVEK
                     PNKPKSNWAVTGLYFYDNNVIDIAKKIKPSHRGELEITSVNEVYLKNNELTVELLGRG
                     FAWLDTGTHDSLIEASNFVETVQRRQGMMVACPEEIAWRNGWLSNEDLYKLGTKIKKN
                     LYGKYLIDLVK"
     CDS             4288..4692
                     /note="O187_04"
                     /gene="wbaU"
                     /codon_start=1
                     /transl_table=11
                     /product="putative dTDP-6-deoxy-3,4-keto-hexulose
                     isomerase"
                     /protein_id="BAQ02083.1"
                     /db_xref="GI:733167579"
                     /translation="MNVEFIPLQKHGDERGMLVALEQAKNIPFEIKRVYYMFGTQGNV
                     RRGYHAHKKIRQVAIPLNGSCRFHLDNGREKIDVVLDDPALGLLIEPGVWHEMYDYSK
                     NCILLVLASDIYDENDYIRNYEDFMRSVKNDS"
     CDS             4682..5140
                     /note="O187_05"
                     /gene="wbaV"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyltransferase"
                     /protein_id="BAQ02084.1"
                     /db_xref="GI:733167580"
                     /translation="MIHKLSDVQTIHIGKKTRVWQYSVILPGAVIGDECNICAHTLIE
                     NDVVIGDRVTIKSGVYIWDGVFIEDDVFIGPCVTFTNDKIPRSKKYPEKFLKTIIKKG
                     ASIGANATILPGITIGENAMVGAGTVVTKDVAPYTVIAGNPGKVIRDIKE"
     CDS             5143..6246
                     /note="O187_06"
                     /gene="wbaW"
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminotransferase"
                     /protein_id="BAQ02085.1"
                     /db_xref="GI:733167581"
                     /translation="MIDFLNLKRINEKYKAEMQDAFNRVVDSGWYIMGKELKSFESNF
                     AQYCGVKYAIGVANGLDALYLVLKAWKEQGKLRDGDEVIVQANTYIASILAITNNNLT
                     PILIEPDENSYNLNPELIRSKITAQTRAILVVHLYGQMSPMKAIMEIANEYNLLVLED
                     CAQAHGAQLDNIKAGNWGHAAGFSFYPGKNLGALGDAGAITTNDDELASVINAIRNYG
                     SHKKYHNVYQGVNSRLDELQAALLNVKLKYLDEDNSARQKIASRYISEIKNKHITLPV
                     SKNVEEHVWHLFVIKTEKREELVTYLNNNDIMTMIHYPIPPHKQVAYKEFNGLSFPLT
                     EQLHDKVLSLPIDPTMTDCDIEYVIKVVNGFVG"
     gene            6243..7508
                     /gene="wzx"
     CDS             6243..7508
                     /gene="wzx"
                     /note="O187_07"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAQ02086.1"
                     /db_xref="GI:733167582"
                     /translation="MNKLLSVTFLTGLLTFARMVAGFIVAKIVAIYTGPTGIAMLGQL
                     QNVINGVSGLVNSPLNTSIVRFTAENYRTGYEECAIWWRVSIRWAIIIYAVIAPMMVV
                     LSKQLSSFLFESDLYYWVIIASALALPFTAVGTLINSIINGQQLYIQYVLLGMVSVII
                     SSMIMISLVVIKGVEGALIALALQNAIIGIAMFGYGLRRPWFKLQYFFGNISKEQSKI
                     ILGYTFMALVSALTMPVVLMLIRKFLVMEVGWEHTGYWQAVWKISETYLAVVTMSLSI
                     YYLPQLSSINDITSLRKEIYKTVKVVMPIVILMAFAIYMLRDIAISLLFTETFKGARD
                     LFLVQLCGDVVKILSWLFAYALISRGETKLFIASEAISAITFILLAFFCIKFYGVQGA
                     NIAYLANYVIYFILIYYCVFYRLKSHRCQ"
     CDS             7518..8459
                     /note="O187_08"
                     /gene="wceX"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02087.1"
                     /db_xref="GI:733167583"
                     /translation="MELLEKIITVCVVTYNSFTTVIKTLESIKKQTYDTNFIELIIAD
                     DCSSDDTVIIVKKWIEENKCIFNNVVLIEQKQNIGLTKNINSAWKLAKGSWVKSIAGD
                     DILLENCIANNITYVNKHNIQSVVFSLMRSFTEDNNKITFHEIYPNSYQQKVLKGERD
                     EQIKYLTHAGGFACAPSAFINRRLLEEVGFADERFFMLEDTPLWFRILKKGEKIYFMN
                     IFTVKYRIGNSISQSNKSLFNVRHLSQKMEVDFLLFKNEVGLIANIRKFIFYFICFFL
                     VFTTGANKNFISKTVFRLALLVKPFWLREKIKNAKII"
     gene            8443..9720
                     /gene="wzy"
     CDS             8443..9720
                     /gene="wzy"
                     /note="O187_09"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAQ02088.1"
                     /db_xref="GI:733167584"
                     /translation="MLKLYKNKAQEYYLLICLFLCVFNFYVPSVGPALYISIAMVFVY
                     LVVNIKSLCKYNSVISRAYVSYIFIYGLPFLFLICFVGVRTILSGSGDTSFLFLLIKY
                     FVFGCVASLFAVAIFISSEITSLSDVQALFYRITLVQSLIIIAAVLSPSISEFVRLYQ
                     NNDANNSSLVLEGLRGVALSSMQFYSLACYFCIITILLADDFINNKIGYLKTSVFLLL
                     MAISSIFISRTAIIGVLLFFVYTLNPFIKYGKKRSVAMALMFLVLTLVFLLFSGLIFT
                     EQVSIIQQKVLPWAFELIYRYSETGSFSTASTDELKSMYFSLNEITMLIGDGKYTGDT
                     PGTYYMGTDAGYMRPTLFGGFFLILAMLVIWILWLKNTFYPKKGGVLFISLVILSLIL
                     QYKGEFIITNYCTLILLSTLLMVSQLLKQKFRG"
     CDS             9724..10827
                     /note="O187_10"
                     /gene="weuF"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02089.1"
                     /db_xref="GI:733167585"
                     /translation="MAVKKKICFFAIDLYERGGLQRVTIDIANQLSNYCEVYILTFQN
                     EGFNSFAYRLDKRVQVTYLKRMCKTRTLKRKAQSILQMCHIRRYLKLHNFDSFISVGM
                     ASVVWTCIPQLMLRCRYICWDHTSFLRTDTWAVRGRRLSRLFADKIVVLTSKDAALWK
                     SSKVSVIYNPSPFDIRRADCEISRYRKKNQIVSLGRFVPVKGFDRLLDIWKIVNSKCS
                     DPFSLMLIGEGPLKEHLTERIVNENIPNISIEPFTENINIVYCESKIQLLTSTFEGLS
                     MVLIEGMTYCLPAISFDIPSGPGEIVDDGITGYLVEDNENEVFADKIILLMSNDSLLF
                     KLSDNCKKKRNIFDASEIIDHWLSLLNIKCGKA"
     CDS             10812..11903
                     /note="O187_11"
                     /gene="weuG"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02090.1"
                     /db_xref="GI:733167586"
                     /translation="MWKSMNILFLSNASGYGGSERTLEILAKHMAKKNKVTVFVQNEI
                     HRDKLNESGICVIEADKGWIVKKIIKDLYLIYDEIMRNDGVIANTNKAAMYLAILSFF
                     LPKRKIKKSIVFVRDFQWKYCHFIFWALSNSIICVASPAVKEYVNKYKVRPLVIPNPI
                     EFKYKALSLDVGKEDMSTPIILCPAMISRWKGLEYLIRSLALIETDCQLYIIGKIVDE
                     EYYSFIKDEVVLLKLSERVRFVDFTSDISNYYKMSTVIVNTSISDYGGPETFGRTIIE
                     GWSFKKPVVSFDCGGPKYLIQNNVDGVLVKEKSVFDLACALQKILHDRNYSNMLGMNG
                     YNKALQKYNVDIITKTILKELYETAVRNK"
     CDS             11900..13051
                     /note="O187_12"
                     /gene="wbwV"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02091.1"
                     /db_xref="GI:733167587"
                     /translation="MIFACRQISFLTIIQYGERMYIIIDARMINASGIGTYIKNLLRE
                     INKYDSIRLQCIINHEHIEEVKSIGINDYIIFKAGFFSPFEQLEYIVKLPSADIFWTP
                     HFNTSIFSLKDKFKKRVVTIHDMFPFAYRDSYKKSHFFYIKFLMKKAAKISDLILTVS
                     NFSKVQIIDYLDVSEEKVLVVPLGVDPDFLNTSNSSSVKKKYILCVGNVKPHKNIKRA
                     IKAFIAVADEIPSYELVIVGKSEGFYSPEDNLKELIQGNKRVHFTGFVSIEELKKYYS
                     EASMLLFPSLYEGFGLPLLEAMSFGLPIAASARASLPEVGKNAIIYFDPESVDDIGNA
                     IVGIINGDVKCNTLAYQSILNEYTWEKCTSETLNSFRKLVLENESSSNR"
     CDS             13029..14144
                     /note="O187_13"
                     /gene="wejO"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ02092.1"
                     /db_xref="GI:733167588"
                     /translation="MKVLQIGKFFYPVRGGVETVAYDIAELLNSKKIKCDVLCTNKNQ
                     TTTIELHNGYKVYRSGIIGSAFSTQISLQYIKTLKNIIDDYDILHVHLPNPLANIAII
                     LANTKDKKIVLHWHSDIIKQKYLLKLYRPFQNWLLKKADAIIGTSQNYIDNSSDLLPF
                     RYKCVPIPIGIDPHRLLAEHHKVKNIKEKFSGKKIILSLGRHVYYKGFNYLIEAAQYL
                     SDDYVILIGGDGPLTSVMHDRIKTLNLTNRVFLIGSIPGNDLGSYFEACDVFCLPSIM
                     KSEAFGIVQIEAMSFGKPIVATNIQGSGTSWVNENKVSGLNVDIKNPEQIASAIYNIT
                     CESVRYREYCNSSFERFNQFFHRNVMIDHIIKLYQTL"
     gene            14166..15563
                     /gene="manC"
     CDS             14166..15563
                     /gene="manC"
                     /note="O187_14"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ02093.1"
                     /db_xref="GI:733167589"
                     /translation="MIVPIIIAGGTGSRLWPLSRSLYPKQFLPLVNESTMIQDTIDRL
                     KYIEHLDPIIICNEEHRFIVAEQLREKEYKHNGIILEPVGKNTAPAVALGAHRALEIT
                     NDPILLVLAADHSILNIHNFSEAVNLANEAAISGKLVTFGTVPSAPETGYGYIKKGGL
                     ISNGIYQVEKFVEKPDRITAQKYIESHNYLWNSGMFMFHAKSFLSELCKFNSKMNSAC
                     KQTYTNAKKDLEFIRLPHDDFIKCPEDSVDYAVMEHTSNAVVIPLDAEWNDVGSWSSL
                     WDISAKDIQGNGTKGDVITINTQNSYIHASDRLVTSVGLNDVIIVETKDAILVANKNN
                     VQDVKELVNRLKSLNRKEYIEHSQCYRPWGQHESIAHGPRFHVKHVIVKPGEKITEQV
                     HFHRTEHWIVVSGTAKVTKNEVSFIMKENESTFIPAGTVHTLENPGKIQLEVIEIQSG
                     NYLDDDDILRFDVKK"
     gene            15577..17013
                     /gene="manB"
     CDS             15577..17013
                     /gene="manB"
                     /note="O187_15"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ02094.1"
                     /db_xref="GI:733167590"
                     /translation="MNNYLLKSKALIVNCNVVFGTSGARGLVIDFSHDVCAAFTHAFL
                     SVIDDKYNFNKVALAIDNRPSSYEIAQACAYAIKQHGFEVEYHGVIPTPALAHYSMQK
                     NIPCIMVTGSHIPFDRNGLKFYRPDGEITKEDELAIINSEYTFSPVGVLPHLETSTQG
                     ADYYLERYVSLFNPETLKGKRIGVYEHSSAGRDLYAPLFNQLGAEVISLGRSDEFVPI
                     DTEAVSDEDRILAREWSKKYNLDAIFSTDGDGDRPLVADENGEWLRGDILGLLTAIEL
                     NIKALAIPVSCNTAIEESNKFASIQRTKIGSPYVIAAFADLAKQFDSVAGFEANGGFL
                     LASDLQINGKELKSLPTRDAVLPALMLLIASRNSTISQLINNLPQRFTWSDRVKNFPS
                     DSSQQIIKNAISSPNNFFNNLGYESLSCSAIDETDGARFTLNNGDIIHLRPSGNAPEL
                     RCYAEASDENQAKQYVANVLGNITSLIS"
     gene            17210..18616
                     /gene="gnd"
     CDS             17210..18616
                     /gene="gnd"
                     /note="O187_16"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ02095.1"
                     /db_xref="GI:733167591"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            18865..20031
                     /gene="ugd"
     CDS             18865..20031
                     /gene="ugd"
                     /note="O187_17"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ02096.1"
                     /db_xref="GI:733167592"
                     /translation="MKITISGTGYVGLSNGILIAQNHEVVALDIVQAKVDMLNKKQSP
                     IVDKEIEEYLATKDLNFRATTDKYDAYKNADYVIIATPTDYDPKTNYFNTSSVEAVIR
                     DVTEINPNAVMVIKSTIPVGFTKSIKERLGIDNLIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD"
     gene            20121..21155
                     /gene="wzz"
     CDS             20121..21155
                     /gene="wzz"
                     /note="O187_18"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ02097.1"
                     /db_xref="GI:733167593"
                     /translation="MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLV
                     QLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYTNAMNVIYGS
                     AVPKVSDIQASLIGRYSTAFSALAETLDNQEEAEKLTIEPTVKNQSLPLAVSYVGETP
                     EGAQKQLAKYIQQVDDQVNEELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQ
                     IQEALQYANQAQVTKPQIQQTQDVTQDTMFLLGSEALESMIKHEATRPLVFSSNYYQT
                     RQNLLDIDNLDVDKLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLG
                     SNALRNYNAK"
     gene            complement(21254..21865)
                     /gene="hisI"
     CDS             complement(21254..21865)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAQ02098.1"
                     /db_xref="GI:733167594"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ"
BASE COUNT     6823 a   3829 c   4708 g   6810 t
ORIGIN
        1 gctaattacg ccatcttacg ccagggattt cataaccaga ttatcggtgc caacatcacc
       61 aactgtaagt tcagcgactt acagggggac gctattgaat ggaacgtggc gattaacgac
      121 agtgatattt tgatctccga ccatgtcatc gagcgcatca actgtaccaa cggcaaaatc
      181 aactggggca tcggtatagg ccttgcggga agcacttacg ataataatta cccggaagac
      241 caggcagtga aaaactttgt cgtggcgaat atcacgggat cggattgtcg gcagttgatc
      301 catgttgaaa atggtaaaca ttttgttatt cgtaatatca aagcctgcaa tatcacgccg
      361 gatttcagta agaaagcagg tattgataac gccacagtcg ctatttacgg ttgtgacaat
      421 ttcgtgattg ataatattga aatgattaat agcgccggga tgttaatcgg ctatggggta
      481 attaaaggca aatatctctc gataccgcaa aatttccgag tgaataatat tcaactggat
      541 aatacccacc ttgcttacaa attgcgcggt atccaaatct ccgccgggaa tgctgtctcc
      601 tttgtggcgc tgactaacat tgagatgaag cgtgcgtcgc tggagttaca caacaaaccg
      661 caacatcttt ttatgcgtaa tatcaaggtg atgcaggaat cctcagttgg accagcattg
      721 agcatgaact tcgacatgcg caaagacgtt cgcggcgtct ttatggcgaa aaaagaaaca
      781 ctgctgtctc ttgcaaatgt tcatgcggtg aatgaaagtg ggcaaagctc cgtcgatatc
      841 gacaggataa atcaccatat tgttaatgtg gaaaagatta actttagatt gccggaacgg
      901 agggagtaga tttgcgacca ttcctggaaa aatggagcca tacttaggaa caatgctact
      961 gcaatccaca acgaagcggc gtaacatcac aagtaattca gtaatcaatt cagggtaatt
     1021 gatgctggcg aaaaaaatcg aacaagctat aattcagcaa ccattttaca ggtggatgaa
     1081 ataatgacga atttaaaagc agttattcct gtagcgggtc ttgggatgca tatgttgcct
     1141 gccactaagg cgattcccaa agagatgcta ccgatcgtcg acaagccaat gattcagtac
     1201 attgttgacg agattgtggc tgcagggatc aaagaaatcc tcctggtaac tcacgcgtcc
     1261 aagaacgcgg tcgaaaacca cttcgacacc tcttatgaat tagaatctct ccttgaacag
     1321 cgcgtgaagc gtcagctgct ggcggaagtg cagtccattt gcccgccggg cgtgacaatt
     1381 atgaacgtgc gtcagggcga acctttaggt ttgggccact ccattttatg tgcacgaccc
     1441 gccattggtg acaacccatt tgtcgtggtg ctgccagacg ttgtgatcga cgatgccagc
     1501 gccgacccgc tgcgctacaa ccttgcagcc atgattgcgc gcttcaacga aacgggccgc
     1561 agccaggtgc tggcaaaacg tatgccgggc gatctctctg aatactccgt cattcagacc
     1621 aaagagccgc tggaccgtga aggcaaagtc agccgcattg ttgaatttat cgaaaaaccg
     1681 gatcagccgc agacgctgga ctcagacatc atggccgttg gtcgctatgt gctttctgca
     1741 gatatttggc cggaactgga acgcactcag cctggtgcat gggggcgtat tcagctgact
     1801 gatgctattg ccgaactggc gaaaaaacag tctgttgatg caatgctgat gacaggagac
     1861 agctacgact gcggtaaaaa aatgggttat atgcaggcgt ttgtgaagta tggactacgc
     1921 aacctgaaag aaggggcgaa gttccgtaaa ggtattgaga agctgttaag cgaataatga
     1981 aaatctgacc ggatgtaacg gttgataaga aaattataac ggcagtgaag attcgtggcg
     2041 aaagtaattt gttgcgaatt ttcctgccgt tgttttatat aaacaatcag aataacaacg
     2101 agttagcaat aggattttag tcaaagtttt ccaggatttt ccttgtttcc agagcggatt
     2161 ggtaagacaa ttagcgtttg aatttttcgg gttaagcgcg agtgggtaac gctcgtcaca
     2221 tcgtaggcat gcatgcagtg ctctggtagc tgtaaagcca ggggcggtag cgtgcattaa
     2281 tacctctatt aatcaaactg agagccgctt atttcacagc atgctctgaa gtaatatgga
     2341 ataaattaag tgaaaatact tgttactggt ggcgcaggat ttattggttc tgctgtagtt
     2401 cgtcacatta taaataatac tcaggatagt gttgttaatg tcgataaatt aacgtacgcc
     2461 ggaaacctgg aatcacttgc tgatgtttct gactctgaac gctatgtttt tgaacatgcg
     2521 gatatttgcg atgctgctgc aatggcgcgg atttttgctc agcatcagcc ggatgcagtg
     2581 atgcacttgg ctgctgaaag ccatgtggat cgttcaatta caggccctgc ggcatttatt
     2641 gaaaccaata ttgttggtac ttatgtcctt ttggaagcgg ctcgcaatta ctggtctgct
     2701 cttgatggcg acaagaaaaa tagcttccgt tttcatcata tttctactga cgaagtctat
     2761 ggtgatttgc ctcatcctga cgaagtaaat aataaagaac aattacccct ctttactgag
     2821 acgacagctt acgcgcctag tagtccttat tccgcatcaa aagcatccag cgatcattta
     2881 gcccgtgcgt ggaaacgtac ctatggttta ccgaccattg tgactaactg ttcgaataac
     2941 tacggtcctt atcactttcc ggaaaaattg attccactag taattcttaa tgctctggaa
     3001 ggtaaggcat tacctattta tggcaaaggg gatcaaattc gtgactggct gtatgttgaa
     3061 gatcatgcgc gtgcgttata taccgtcgta accgaaggta aagcgggtga aacttataac
     3121 attggtggac acaacgaaaa gaaaaacatc gatgtagtgc tcactatttg tgatttgttg
     3181 gatgagattg taccgaaaga gaaatcttac cgcgagcaaa ttacttatgt tgccgatcgc
     3241 ccgggacacg atcgccgtta tgcgattgat gcagagaaga ttagccgcga attgggctgg
     3301 aaaccgcagg aaacgtttga gagcgggatt cgtaaaacaa ttaactggta tttgaataat
     3361 aatgattggt gccggcgagt tcaagatggc tcttatcaac gtgagcgttt gggggtaatt
     3421 agatgaaagg aattatttta gctggtggtt ctggaacaag gctttatcca attacaatgg
     3481 gagtttcaaa gcagctatta cccatttatg ataaaccgat gatttattat cctttgtcag
     3541 tgctgatgtt ggcaggtata caagatattc ttattattac aacgccagaa gatcagcagg
     3601 ggttcataag attacttggg aacggaagcc aatttggtat taatcttaat tacgccactc
     3661 aacggaatcc tgatggttta gctcaggcct tcatcatcgg ggaacaattt attggtgagg
     3721 attctgtctg cttagttttg ggagataata ttttttttgg tcaaggattt actccgaaac
     3781 ttagatgcgc cgctgagagg gaaataggag ccacgatatt tggttatcag gtaatggatc
     3841 ctgaacgatt cggtgtggtc gaatttgatt gcaattataa agcattaagt attgttgaaa
     3901 aaccaaataa accaaaatca aactgggctg taactggatt gtatttttac gataacaatg
     3961 ttattgatat tgcaaaaaaa ataaaaccgt cgcatcgtgg tgaattagaa atcacatctg
     4021 ttaatgaggt ttacttaaaa aataatgagt taactgttga gttattaggt cgagggtttg
     4081 cgtggctgga taccggcaca catgatagtc tcattgaagc atctaatttt gtcgaaaccg
     4141 ttcaacgtag acaaggaatg atggttgcat gccccgaaga aatagcttgg cggaatggtt
     4201 ggttatctaa tgaagattta tataaattag gcacgaaaat taaaaagaat ctatacggaa
     4261 aatatcttat cgatttggtg aaataatatg aatgtcgagt ttattccatt acaaaaacat
     4321 ggtgatgaaa gagggatgtt agtagcccta gagcaagcca aaaacattcc atttgaaatt
     4381 aaacgtgttt attatatgtt tggaactcaa ggaaatgttc ggcgcgggta tcatgcccat
     4441 aaaaaaatta ggcaagtagc gataccgcta aatggttcat gccgttttca tttagataat
     4501 ggtcgtgaga aaatagatgt tgttttagat gatcctgcat tagggttgct tatagagcct
     4561 ggagtctggc atgaaatgta cgattactca aagaactgta ttcttctagt attggcgagc
     4621 gatatttatg atgaaaatga ctatattaga aattatgagg attttatgag gtctgttaaa
     4681 aatgattcat aaattaagcg atgttcaaac tatccatata ggtaaaaaaa caagggtctg
     4741 gcaatattca gttatattac cgggtgctgt aattggtgat gagtgtaaca tatgtgcaca
     4801 tacacttatt gaaaatgatg ttgtaattgg ggatagagtt actattaaat cgggcgtata
     4861 tatttgggat ggggttttta ttgaagatga tgtatttata gggccctgtg taacatttac
     4921 caatgataaa atccccaggt caaagaaata cccagaaaaa tttcttaaga ctattattaa
     4981 aaaaggtgct tccattggag ccaatgcaac tatattacct ggaataacaa ttggtgaaaa
     5041 tgctatggtt ggggctggta ccgtagtcac taaagatgtt gcaccttata cagtcattgc
     5101 aggtaatcca ggtaaagtta ttagggatat taaggaataa aaatgatcga ctttctcaac
     5161 ttaaaaagaa tcaatgaaaa atataaagcg gaaatgcaag atgcctttaa tcgagttgtc
     5221 gattctggct ggtatattat ggggaaagaa ttaaagtctt ttgagagtaa ttttgcgcag
     5281 tactgcgggg tgaaatatgc aataggtgta gctaatggat tagatgctct ctatctcgta
     5341 ttaaaagcgt ggaaagaaca ggggaaattg agagatggtg atgaagtgat agttcaagca
     5401 aatacgtaca ttgcttccat tctcgctata accaacaata atcttacacc tatattaata
     5461 gaacctgatg aaaatagtta taatttaaac cctgaattaa ttcgctctaa aataacggcg
     5521 caaacaagag cgatattggt agttcatcta tatggccaaa tgtcaccgat gaaagcgata
     5581 atggaaatcg ctaatgaata taatttgtta gtattagagg attgcgcaca agcccatggt
     5641 gctcaattag ataatattaa agctggtaac tgggggcatg ctgcaggttt cagtttttat
     5701 cccgggaaaa atttaggcgc cttaggggat gcgggagcaa ttacaacaaa tgatgacgaa
     5761 ttagcgtcag taataaatgc aattagaaat tatggttctc ataaaaaata ccataatgtt
     5821 tatcaaggtg ttaatagtcg tctcgatgaa ctgcaggcag cattattaaa tgtgaaacta
     5881 aaatatcttg atgaagacaa ttccgctcga cagaaaatag cttctagata tatttcagaa
     5941 ataaaaaata aacatatcac gttgcctgtt tctaagaatg ttgaagaaca tgtctggcat
     6001 ctttttgtta taaaaaccga aaaaagagaa gagttggtta catatttgaa taataatgat
     6061 atcatgacta tgattcacta tcctattcca ccgcataaac aagttgcata taaagagttc
     6121 aatggtttga gctttccatt aacagagcag ttacatgata aggttttatc tctcccaata
     6181 gatccaacaa tgaccgattg tgatattgaa tatgtaataa aagttgtaaa tggctttgtc
     6241 ggatgaataa gttgctctcg gtaacattcc ttacaggcct actaactttc gcaaggatgg
     6301 ttgctgggtt tatcgttgcg aaaattgtag ctatttatac tggcccgaca ggaatcgcaa
     6361 tgttaggtca attgcaaaat gtaattaatg gtgttagtgg attggttaat tcaccgctta
     6421 atacatctat tgtcagattt actgcggaaa attatagaac aggatatgaa gaatgtgcaa
     6481 tatggtggcg agtaagtatt agatgggcta ttattatcta tgcggtaatt gcgccaatga
     6541 tggttgtatt atcgaagcag ctttcatctt ttctatttga atccgattta tattattggg
     6601 ttataatcgc ttctgcttta gcattaccat tcacagcggt aggaacccta attaattcta
     6661 taataaatgg tcagcaatta tacattcaat atgttttgtt agggatggtg tctgtcataa
     6721 tttcgtcgat gattatgatc agtcttgttg taattaaagg agtagaaggc gcattaattg
     6781 cattagccct ccagaatgca ataattggca ttgctatgtt tggatatggt ttacgaagac
     6841 catggttcaa attacaatat tttttcggaa atatatcaaa agagcaatca aaaatcattc
     6901 tcggttatac atttatggca ttggtatcgg cattaacaat gcctgtagta ttaatgttga
     6961 tacgtaaatt cttagtcatg gaagttggat gggagcatac agggtactgg caagctgtct
     7021 ggaaaatatc tgaaacatat ttggctgtgg ttaccatgtc attatctata tattatttac
     7081 ctcaactttc cagtattaac gatatcacaa gcttaagaaa agaaatttat aagacggtta
     7141 aagttgttat gcccatagtc atattaatgg catttgctat atatatgctt cgtgatattg
     7201 caatttcttt attgtttacg gaaaccttta agggggctag agatttattt ttagttcagt
     7261 tatgcggtga tgtagtgaaa attctttcat ggctttttgc ttatgcactt atttctcgag
     7321 gtgaaactaa actatttatt gcttctgaag ctatatcagc aataactttc atcttattgg
     7381 cttttttttg tataaagttc tatggtgttc agggcgcaaa tattgcttat ttagctaatt
     7441 atgtaattta ttttatattg atttattatt gtgtgtttta tcggttaaaa agtcataggt
     7501 gtcaataggt aaataaaatg gaattattgg aaaaaataat aacagtctgt gtagtgacat
     7561 ataattcatt tacaacagta attaaaactt tagaaagtat aaaaaaacaa acttatgata
     7621 caaattttat tgaattaatc attgctgatg attgttcaag tgatgatacc gtaattattg
     7681 taaaaaaatg gattgaagag aataagtgta tatttaataa tgtggtgctt attgaacaaa
     7741 aacaaaacat tggcttaact aaaaatatca attcagcatg gaaattggca aaaggcagtt
     7801 gggtgaaatc cattgcagga gatgatatct tactcgaaaa ttgcatagca aataatatca
     7861 cttatgtaaa caagcacaat atacaaagtg tagtcttttc tttaatgcgc tcttttacag
     7921 aagataataa taaaataact tttcatgaaa tataccccaa ctcataccag caaaaagtgt
     7981 tgaaaggaga acgagacgaa caaattaagt atcttactca tgccggaggt tttgcctgtg
     8041 ctccctctgc ttttattaac aggaggttac ttgaagaggt tggttttgca gatgagcggt
     8101 tttttatgtt agaagataca ccactttggt ttcgcatact aaaaaaagga gaaaaaatat
     8161 attttatgaa catttttact gtaaaataca ggattggaaa ttcgatatcg cagtcaaata
     8221 agtctttatt taatgttcgt catttgagtc aaaaaatgga agtcgatttt ctgttattta
     8281 aaaatgaagt aggtctaata gccaatataa gaaaattcat attttatttt atttgttttt
     8341 ttttggtttt tacgactggt gcaaataaga actttataag caaaacagtt tttagattag
     8401 ctttgttagt taaacctttc tggttaagag aaaaaataaa aaatgctaaa attatataaa
     8461 aataaagccc aagagtatta tttacttatt tgcttgtttt tgtgtgtttt taacttttat
     8521 gtgccttctg ttggtcctgc tttgtatata tcaattgcaa tggtttttgt ttatcttgtc
     8581 gtcaatatta agtcgttatg taaatataat agtgtaatat ctagggctta tgtttcatat
     8641 atatttatat atggattgcc ttttttattc ttaatatgtt ttgtcggagt tagaacaata
     8701 ttgtcaggga gtggtgatac atcatttttg tttttactta ttaagtattt tgtttttggt
     8761 tgtgtcgcat ctctatttgc tgtggcaatt tttataagca gcgagatcac atcattaagc
     8821 gatgtgcagg ctctttttta tagaattacg ctggttcaat cgctaataat tatagctgca
     8881 gtgctgtctc cttctatttc tgaatttgtt cgattatatc agaataatga tgctaacaac
     8941 tcatcacttg tacttgaagg acttagagga gttgccttat caagtatgca attttattca
     9001 cttgcatgct atttttgcat aataactatt ttactggctg atgattttat aaacaataaa
     9061 ataggatatt taaagacgag tgtgtttttg ttgttaatgg ctatttcatc catttttata
     9121 agccgtaccg caattatagg agttttactt ttttttgtat atacattgaa tccattcata
     9181 aaatatggta agaagcgtag cgtagctatg gctctaatgt ttttggtgtt gacattagta
     9241 tttttattat tttctggttt gatatttaca gagcaagttt ctattattca acaaaaagtt
     9301 ttgccttggg cctttgaatt aatttataga tatagcgaga ccggttcatt ttctaccgca
     9361 tcaactgatg aattgaagag tatgtatttc tcattaaatg aaataaccat gcttattgga
     9421 gatggaaaat atacaggtga tacgcctggt acatactata tgggaactga tgctggctat
     9481 atgagaccaa cactttttgg tggttttttt ttgatattag cgatgttggt aatatggatc
     9541 ttgtggttga aaaatacatt ttaccctaaa aaaggaggag tattatttat ctccttggtt
     9601 atattgtctc ttatattaca gtataaagga gagttcataa ttacaaatta ctgcacatta
     9661 attttattgt ctaccttact tatggtttct cagctgttga agcaaaaatt tagggggtga
     9721 ggaatggcag taaagaaaaa aatttgcttc tttgcaatag atctttatga gcgaggtggt
     9781 cttcagcgag tcaccatcga tatcgcaaat cagctttcaa actattgcga agtatatatt
     9841 ttgacttttc agaatgaggg cttcaatagt ttcgcatata gattagataa aagagttcaa
     9901 gtcacttatt taaaacgaat gtgtaaaacg agaactttaa aaagaaaagc tcaatctata
     9961 cttcagatgt gtcatattag acgatatctt aagttacata actttgattc gtttataagt
    10021 gttgggatgg cttctgtcgt atggacttgc atcccccaat taatgcttcg ttgtcgatat
    10081 atatgttggg atcatactag ttttttacgc actgatacat gggccgtaag aggacgtaga
    10141 ctatcaagat tatttgcgga taaaatcgtc gttttaactt ctaaagatgc cgctctttgg
    10201 aaaagttcta aagttagtgt tatatataat ccatctccat ttgatattag gagggcagac
    10261 tgtgaaatat cgaggtatag aaagaaaaat caaatagtat ccttagggcg atttgttcca
    10321 gttaaaggtt ttgacaggct tcttgatatc tggaaaatcg taaattcaaa atgttcagac
    10381 ccattctccc ttatgttaat tggtgaaggg cctctaaagg aacatttaac tgaaagaatt
    10441 gttaatgaaa atattcctaa tatatcaatt gaaccattta ccgaaaatat taatatagtg
    10501 tattgtgagt caaagataca attattaact tcaacttttg aaggactttc aatggtctta
    10561 atagaaggga tgacttattg cttgcctgca atatcttttg acatcccttc agggcctggt
    10621 gaaatagtag atgatggaat tacaggttat cttgttgaag ataatgaaaa tgaagtattt
    10681 gcagacaaga ttatattact tatgtctaat gattctttgc tgtttaaatt gtcagataac
    10741 tgtaagaaaa aaagaaatat atttgacgcc agtgagataa ttgatcactg gcttagtttg
    10801 ctaaatataa agtgtggaaa agcatgaata tattattttt atcaaatgcc tcaggatatg
    10861 gagggagtga gagaacttta gagattttag ctaaacatat ggctaaaaaa aataaagtta
    10921 ctgtatttgt tcagaatgaa atacaccgtg ataaattgaa tgaatctggc atttgcgtaa
    10981 ttgaggcaga taaagggtgg attgtaaaaa aaatcataaa ggatttgtat ttgatttacg
    11041 atgaaattat gagaaatgac ggtgtgattg caaatacaaa caaagctgcg atgtatttag
    11101 caatactttc ttttttctta cctaaaagaa agataaagaa aagtattgtg ttcgtaagag
    11161 attttcaatg gaagtattgt cattttatat tttgggcttt gagtaattct ataatatgtg
    11221 ttgccagtcc tgcggtaaaa gaatacgtaa ataaatataa agttaggcct ttagtaattc
    11281 caaatcctat tgaatttaaa tataaagcac tatccttaga tgttggaaaa gaagatatgt
    11341 caacacctat cattttgtgc cctgctatga tttcaagatg gaaagggttg gagtatttaa
    11401 tcaggtcatt ggcattaatt gaaacagatt gccagctata tattataggt aagattgttg
    11461 atgaggaata ttatagtttc attaaggatg aagttgtttt attaaaacta tctgagagag
    11521 ttagatttgt tgattttaca tctgatatat caaattatta taaaatgtct acagtgatcg
    11581 taaatacatc tatatcagat tatggtggtc ctgaaacttt tggacgaaca attatcgaag
    11641 gatggtcatt taaaaaacca gtagtttcct ttgactgtgg tggtccaaaa tatctcatac
    11701 aaaataatgt tgatggagtt ttggttaagg agaaaagtgt attcgatctt gcatgtgcat
    11761 tacagaaaat attacatgat agaaattatt ccaacatgtt aggaatgaat ggctacaaca
    11821 aagctctgca gaaatataat gtggatatta taacgaaaac gatattaaaa gaattatatg
    11881 aaacagccgt tcgcaataaa tgatttttgc ttgcaggcaa ataagtttct taaccatcat
    11941 tcaatatgga gaacgaatgt atataattat tgatgcaaga atgataaacg cttctggaat
    12001 aggcacatac attaagaact tattacgtga aattaataaa tacgattcga ttagattaca
    12061 atgcatcata aatcatgaac atatagaaga agtcaaaagt ataggtatca atgattatat
    12121 aatttttaag gctggatttt tttctccatt tgaacagctt gaatatatag ttaaattgcc
    12181 ttctgcagat attttttgga caccacattt taacacgtca attttctctt taaaggataa
    12241 atttaaaaaa cgtgttgtga caattcatga tatgtttcct tttgcatatc gagatagtta
    12301 taaaaaatcc cattttttct atattaaatt tcttatgaaa aaagctgcta agataagtga
    12361 tttaatttta acagtatcaa atttttctaa agttcaaata attgactatc ttgatgtgag
    12421 tgaagagaaa gttttagttg taccattggg cgttgaccct gattttttaa atacttctaa
    12481 ttctagcagt gttaaaaaaa aatatatttt atgtgttggt aatgttaagc cacataaaaa
    12541 tattaagcgg gccattaaag catttattgc agttgccgat gaaattcctt catatgagtt
    12601 agtgatcgtc ggaaagtccg aggggtttta ctcaccagaa gataatttaa aggaattaat
    12661 acagggtaat aaaagagttc attttacagg ctttgtgagt attgaagaac taaaaaaata
    12721 ttattcagaa gcatctatgc ttttatttcc ttcactttat gaagggttcg gcctgccttt
    12781 acttgaagct atgtcattcg gattgccaat tgcagcctct gcaagagctt cactaccgga
    12841 agttggtaag aatgctatta tatactttga tcctgaaagt gttgatgata ttggcaatgc
    12901 tatagtcgga ataataaatg gtgatgttaa gtgcaatacc ttagcttatc aatcaatact
    12961 aaacgaatac acatgggaaa aatgtacgtc agaaacctta aatagcttca gaaaattggt
    13021 actagaaaat gaaagttctt caaataggta agttttttta tccggtgagg ggtggggttg
    13081 aaacggtagc ttatgatatt gcagagctat taaattccaa aaaaataaaa tgcgatgtat
    13141 tgtgtacaaa taaaaaccag acaacaacca ttgagttgca taatggttat aaggtatatc
    13201 gttctgggat aattggaagt gcgttttcaa ctcaaatttc tctgcagtat attaaaacac
    13261 taaaaaacat catcgatgat tatgatattt tacatgtgca tttacctaat ccgttagcca
    13321 atatcgcaat cattttagct aatactaaag ataagaaaat cgtgttacac tggcatagtg
    13381 atataattaa acaaaaatat ttgttaaaat tatatagacc tttccaaaac tggttgttaa
    13441 aaaaagctga tgccataatt ggtacatctc aaaattatat tgataattcc agtgatttgt
    13501 tgccgtttag atataaatgt gtcccaattc ctattggaat tgatcctcac cgtttattgg
    13561 cagaacatca taaagtcaaa aatataaaag aaaagttttc gggaaagaaa atcatattat
    13621 cacttggcag acacgtctat tataaagggt tcaattatct tattgaggca gcacaatatc
    13681 ttagcgatga ctatgttatt ttaattggag gtgatggccc tttaacttcg gtaatgcatg
    13741 atagaataaa aacactaaat ttaaccaaca gagtatttct tattggaagc attccaggta
    13801 atgatttagg ttcttatttt gaagcatgtg atgtattttg cttaccatct ataatgaagt
    13861 ctgaggcatt tggaatagtg caaatcgaag ctatgagttt tggtaaacct atagttgcca
    13921 ccaatattca aggctctggc accagttggg ttaatgagaa taaagttagt ggtttaaatg
    13981 ttgatattaa gaatccagag caaatcgcca gtgctatata taatattact tgtgaatcag
    14041 tacgttatcg ggagtattgc aattcatcat tcgagcgatt caatcaattt tttcatcgaa
    14101 atgttatgat tgatcatatt attaagttat accagacact ataaccataa attagcgaga
    14161 gtgttatgat tgtacctatc attatagcgg gtggaacagg cagtagactt tggccattat
    14221 cacgtagcct ttaccccaag caatttttgc ccttggtaaa tgaatcaaca atgatccaag
    14281 atactatcga cagattaaag tatattgaac atttagatcc cattattata tgtaatgaag
    14341 agcatcgttt cattgttgca gagcaactga gggaaaagga atataagcat aatggcatta
    14401 tactcgagcc tgtaggaaaa aatacagctc cagctgttgc tcttggtgcc catcgtgcgt
    14461 tagaaattac taatgatcca atattattag ttttggctgc tgatcactct attttaaata
    14521 tccataattt tagcgaagcg gttaatttag ctaacgaagc agctatttct ggtaaactag
    14581 ttacatttgg aactgtacct tctgctcctg aaactggcta tggatacatt aaaaaaggtg
    14641 gtttaatatc aaatggtata tatcaagttg aaaaatttgt tgagaaacca gataggataa
    14701 ctgcacaaaa atatatcgaa agtcataatt atttatggaa tagcggcatg tttatgtttc
    14761 atgctaaatc ttttttaagt gaactatgta agttcaattc taaaatgaac agtgcatgta
    14821 agcagacata tactaatgct aaaaaagatt tggagtttat cagattacct catgatgact
    14881 ttattaagtg tccagaggat tctgtagact atgctgtaat ggagcacact agcaatgcag
    14941 tagttatacc gttagatgca gaatggaatg acgttggatc ttggtcatct ctttgggata
    15001 taagtgctaa agacatccaa ggaaatggta caaaaggtga tgtgattaca attaataccc
    15061 aaaatagtta tatacatgcc agcgatcgac tagttacatc cgttggatta aatgatgtta
    15121 taattgttga aacaaaagat gcaatactgg tagcaaataa gaataacgtt caagatgtaa
    15181 aagaacttgt taatagactt aaatctctaa atcgtaagga atatattgaa cattcacaat
    15241 gctatagacc ttgggggcag catgaaagta tagctcatgg gccaaggttt catgtgaagc
    15301 acgttatcgt aaagcctggc gaaaaaatta cagagcaagt tcattttcat agaactgagc
    15361 attggattgt tgtttcaggt acagcaaaag ttacgaaaaa tgaagtatct tttattatga
    15421 aagaaaacga atcaacattt attcctgcgg gtacagtgca tactttagaa aatccaggta
    15481 aaattcaact cgaggtaata gaaatccaat caggaaatta tttagatgat gatgatattc
    15541 ttcgttttga cgtaaaaaaa taagaaggga aatcatatga ataattacct tttaaaatct
    15601 aaagcgttaa tcgtgaattg caatgttgta tttggcacaa gtggtgctcg cggtttagtg
    15661 atcgattttt cccatgatgt ttgtgctgcg ttcactcatg cgtttctttc tgttattgat
    15721 gacaaataca attttaataa agttgcctta gccattgata accgcccaag tagttacgaa
    15781 attgctcagg catgcgcgta tgctataaaa caacatggat tcgaggttga atatcatggt
    15841 gtaattccga ctcctgcatt agctcattat tcgatgcaga aaaacattcc ctgcataatg
    15901 gtcacaggga gtcatatccc ttttgatcgt aatggcttaa aattctacag acctgatggt
    15961 gaaatcacta aagaggatga gctcgcaatt ataaatagtg agtatacatt ttcgcctgta
    16021 ggtgtattac ctcatcttga aacaagcact caaggtgcag actactacct cgagcgttat
    16081 gtttctcttt ttaatcccga gactttaaag gggaaaagaa taggggtata tgaacattct
    16141 agtgcaggac gcgatttata tgctcctctt tttaatcaat tgggtgcaga ggtcatttcc
    16201 ctcggtagaa gtgatgagtt cgttccgatt gatacggaag cagtaagcga tgaagatcgt
    16261 atacttgcaa gagagtggtc taaaaaatat aaccttgatg ctattttctc aacagatggc
    16321 gatggtgatc gtcctttagt tgccgatgaa aatggtgaat ggttaagagg cgatattctg
    16381 ggattgctta ctgctattga acttaatatc aaggcgttgg ctattccagt gagttgtaat
    16441 acagcaattg aagagtctaa taaatttgca agtatacaac gaacgaaaat aggttctcct
    16501 tatgtaattg cagcgtttgc agatcttgct aagcaatttg attcagtcgc tggttttgaa
    16561 gctaatggtg gttttctcct tgcctccgat ttacaaatta atggaaagga attaaaatcg
    16621 ttacctacac gggatgctgt gttaccagca ttaatgctct taatagcctc tcgcaatagt
    16681 actatatctc aattgattaa taatcttcct cagcgattca cttggtcaga tagagttaaa
    16741 aacttccctt cagattcaag tcaacaaatt ataaaaaatg ccatatcatc acccaataat
    16801 ttctttaata atttaggtta cgaatcatta tcctgttccg ctattgatga aacggatggt
    16861 gcaagattta ctttaaataa tggtgatatt atacatctcc gtccttccgg taatgctcca
    16921 gaactccgtt gttatgctga ggccagtgat gaaaatcagg ctaagcaata tgttgcgaat
    16981 gtgctgggaa atattacctc tttgatttct tgatgttata gatttatcta cgcttatatg
    17041 tgtgcgtagg tttgattaca cgtagatgcc ggtatacaga attgaagaac ggtatttgtt
    17101 gcattaatga aattcagcac tacacacatt cgtgcaactt gagataacat ctcaatcata
    17161 ttcaagtcgc gcatacatcg cggtgaacac cccctgacag gagtaaacaa tgtcaaagca
    17221 acagatcggc gtcgtcggta tggcagtgat ggggcgcaac cttgcgctca acatcgaaag
    17281 ccgtggttat accgtctcta ttttcaaccg ttcccgtgag aaaacggaag aagtgattgc
    17341 cgaaaatcca ggcaagaaac tggttcctta ctatacggtg aaagagtttg ttgaatctct
    17401 ggaaacgcct cgtcgcatcc tgttaatggt gaaagcaggt gcaggcacgg atgctgctat
    17461 tgattctctc aagccatacc tcgataaagg cgacatcatc attgatggtg gtaacacctt
    17521 cttccaggac accatccgtc gtaatcgtga gctttctgca gaaggcttta acttcatcgg
    17581 taccggtgtt tccggcggtg aagaaggtgc gctgaaaggt ccttccatta tgcctggtgg
    17641 gcagaaagaa gcctatgaac tggttgcacc gatcctgacc aaaatcgccg cagtagctga
    17701 agacggtgag ccatgcgtta cctatattgg tgccgatggt gcaggtcact atgtgaagat
    17761 ggttcacaac ggtatcgaat acggcgatat gcagctgatt gctgaagcct attctctgct
    17821 taaaggtggc ctgaacctca ccaacgaaga attggcgcag acctttaccg agtggaataa
    17881 cggtgaactg agcagctacc tgatcgacat taccaaagac atcttcacta aaaaagatga
    17941 agacggtaac tacctggttg atgtgatcct ggatgaagcg gcaaacaaag gtacgggcaa
    18001 atggaccagc cagagcgcac tggatctcgg tgaaccactg tcgcttatta ccgagtctgt
    18061 gtttgcacgt tatatctcgt ctctgaaaga tcagcgcgtt gccgcgtcta aagttctctc
    18121 cggaccgcaa gcgcagccag ctggcgacaa ggctgagttc atcgaaaaag ttcgtcgtgc
    18181 tctgtatctg ggcaaaatcg tttcttacgc ccaaggcttc tctcagctgc gtgctgcgtc
    18241 tgaagagtac aactgggatc tgaactacgg cgaaatcgcg aagattttcc gtgctggctg
    18301 catcatccgt gcgcagttcc tgcagaaaat caccgatgct tatgccgaaa atccgcagat
    18361 cgctaacctg ttgctggctc cttacttcaa gcaaattgcc gatgactacc agcaggcgct
    18421 gcgtgatgtc gttgcttatg cggtacagaa cggtatcccg gttccgacct tctctgcggc
    18481 agttgcctat tatgacagct accgtgccgc tgttctgcct gcgaacctga tccaggcaca
    18541 gcgtgactat ttcggtgcgc atacttataa gcgcattgat aaagaaggtg tgttccatac
    18601 tgaatggctg gattaatctg atttaaatca attaatcaat gcaaggcccg gagaaaccct
    18661 ccgggctttt ttattataca aagcggcagg ttatggcctt tttttataat ttatagttaa
    18721 aaacgcgata taatacagcg ccgcacagca ggatcgctgc cttgacagtt catctacatc
    18781 agcgttaaaa atcccgcagt agatgaagtt gtggtggtgg attaatgacc actctaaatg
    18841 tttaaccgga agaagtcaga gctaatgaaa ataacaattt caggaacagg ttatgttggt
    18901 ctttcaaatg gtattctgat tgcgcaaaat cacgaagtgg ttgcactgga tatcgttcag
    18961 gccaaagtgg acatgcttaa caagaagcag tcaccgattg ttgataagga gattgaagag
    19021 tatctggcga ctaaagatct caatttccgc gctacgacag ataagtatga cgcgtataaa
    19081 aatgctgatt acgttattat tgccacgcct accgattatg acccgaaaac aaattatttt
    19141 aatacctcaa gcgtggaagc ggtcattcgc gatgtgacag aaattaatcc caacgcggta
    19201 atggtgatta aatctacaat tccggtaggt ttcaccaaat caattaaaga acgtctgggt
    19261 atcgataacc ttattttctc tccggaattc ctccgcgaag gtaaagccct ttacgataat
    19321 ctccatcctt cacgtattgt cattggtgag cgttcagaac gcgcagaacg tttcgctgcg
    19381 ttattacagg aaggcgcgat taagcaaaat atcccaaccc tgtttaccga ctccactgaa
    19441 gcagaagcga ttaaactttt cgctaatacc tatctggcga tgcgcgtagc atactttaat
    19501 gaactggata gctatgcgga aagtttaggt ctgaatactc gccagattat cgaaggcgtt
    19561 tgtctcgatc cgcgtatagg caaccattac aacaatccgt cgtttggcta tggtggttat
    19621 tgtctgccga aagataccaa gcagttactg gcgaactacc agtctgtgcc gaataacctg
    19681 atttcggcaa ttgtcgatgc taaccgcaca cgtaaagact ttattgccga tgccattttg
    19741 tcacgcaaac cgcaagtggt gggtatttat cgtctgatta tgaagagcgg gtcagataac
    19801 ttccgtgcgt cttccattca ggggattatg aaacgtatca aggcgaaagg cgttgaagtg
    19861 atcatatacg agccagtcat gaaagaagac tcattcttca actctcgcct ggaacgagat
    19921 ctcgccacct tcaaacaaca agccgacgtc attatttcca accgtatggc agaagagctt
    19981 aaggatgtgg cagacaaagt ctacacccgc gatctttttg gcagcgacta acatcttgtt
    20041 atcagggcga ttttcgccct gattctctta tgttcccttt gtaataattc attattttta
    20101 tcatttatcc tatagcattc atggcgatta tcgctaaact atggcgactt aaaattattt
    20161 cgtccgttag ggtaatgatg agagtagaaa ataataatgt ttctgggcaa aaccatgacc
    20221 cggaacagat tgatttgatt gatttactgg tgcagttgtg gcgcggcaag atgacaatta
    20281 tcatctctgt cattgttgct attgccctgg ctatagggta tctggccgtt gccaaagaaa
    20341 agtggacttc cacagctatc gttactcaac ctgatgtggg gcaaatcgct ggttatacca
    20401 acgcgatgaa tgtgatctac ggatcggctg taccgaaagt ctccgacatt caggcttcac
    20461 ttatcggacg ttacagcact gcattttcag cattagcgga aacgctggat aaccaggaag
    20521 aagcagagaa gctgaccatt gagcctaccg ttaaaaatca gtcattacct ttagctgtgt
    20581 cttatgtggg tgaaacacct gagggtgcgc agaaacagtt ggcgaagtat atccagcaag
    20641 ttgacgacca ggttaatgaa gaactggaaa aagacctgaa agacaacatc gcgctgcgta
    20701 tgaaaaactt gcaggattct ctgaaaactc aggaagtagt cgcgcaggag cagaaagatc
    20761 tgcgtatccg tcagattcag gaagcgttgc agtatgcgaa tcaggcgcag gtgacaaagc
    20821 cgcagattca gcagacacag gacgtaaccc aggatactat gttccttttg gggagcgaag
    20881 cgctggagtc gatgattaag cacgaggcga ctcgtccgtt ggtgttctca tcaaactact
    20941 atcagactcg tcaaaacctg ctggatatcg acaatcttga cgttgataaa cttgatattc
    21001 atgcttaccg ctatgtaatg aaaccgacgt tacctattcg tcgcgatagc ccgaaaaagg
    21061 caattacctt gattctggcg gtgctgctgg gcggcatggt tggcgcgggg attgtgctgg
    21121 ggagtaatgc tctacgcaat tacaacgcga aataatcttt gcagctttaa agaaaatggg
    21181 cagggtggtg acaccttgcc cgtttttttt ttgccggatg cgacaacaat atcgcatccg
    21241 cttaccccgc aactcactga tgccgtttac gtaggttctc aattaccgtc gttaaatcca
    21301 gatcctgatc ctgcaacagc accagcaggt gatacatcaa atccgatgcc tcgttggtca
    21361 gctcaaagcg gtcatgtacc gttgctgcca gtgcggtttc tacgccttct tcgcccactt
    21421 tctgcgcaat gcgtttggtg ccgctggcat acagtttggc ggtataggag gtttccgggt
    21481 cggcagattt acgttcggcg agcagttgtt ccagttgata caggaacagc cactgatgag
    21541 cggtgtcgcc gaagcagctg ctggtgcctt tgtggcaggt tggcccgatg ggattcgcca
    21601 gcaccagtaa cgtgtcgttg tcgcagtccg gcgcaatact caccacattg aggaaattgc
    21661 ccgacgtttc gcctttggtc cacagtcgct gtttagtgcg cgagaagaag gtgactttgc
    21721 cgctttcgat ggttttgtct aaggcttccg ggttcatata gcccagcatt aacacttcgc
    21781 cggatacagc gtgttgcaca atcaccggca tcagtccgtc ggttttttcc cagtccagtt
    21841 cgcgacgttg ttgttctgtt aacatatcct gatctccacg ccctgtgttg ccaggtacgc
    21901 ttttaattca ccaatattga ttatttgttt gtggaatacg gaagctgcca gcgcgccgtc
    21961 aacgtcggca tcgctgaagg cttcgaggaa gtgttccatg gtgcccgcgc caccggaggc
    22021 aatcagcggg acgtggcaaa cttcacgcac ttttttcagc tgctcgaggt cgtaaccgtt
    22081 acgcacaccg tcctgattca tcatgttgag gacgatttct ccggcaccgc gtttttgcac
    22141 ttcctgtacc cagtcgagcg tttcccactg
//
