LOCUS       AB811616               21940 bp    DNA     linear   BCT 13-MAY-2015
DEFINITION  Escherichia coli DNA, O-antigen biosynthetic locus, strain: H7.
ACCESSION   AB811616
VERSION     AB811616.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. 22 (1), 101-107 (2015)
   PUBMED   25428893
  REMARK    DOI:10.1093/dnares/dsu043
REFERENCE   2  (bases 1 to 21940)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..21940
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="H7"
                     /db_xref="taxon:562"
                     /note="serogroup:O39"
     gene            <1..902
                     /gene="wcaM"
     CDS             <1..902
                     /gene="wcaM"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="BAQ00868.1"
                     /translation="AILRQGFHNQIIGANITNCKFSDLQGDAIEWNVAINDRDILISD
                     HVIERINCTNGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENG
                     KHFVIRNIKARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKG
                     KYLSIPQNFRVNNIQLDNTHLAYKLRGIQISAGNALSFVALTNIEMKRASLELHNKPQ
                     HLFMRNIKVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNEKGQSSVD
                     IDRINHHIVNVEKINFRLPERRE"
     gene            1065..1970
                     /gene="galF"
     CDS             1065..1970
                     /gene="galF"
                     /note="O039_01"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ00869.1"
                     /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYI
                     VDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVT
                     IMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNE
                     TGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGR
                     YVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQA
                     FVKYGLRNLKEGAKFRKGIEKLLSE"
     gene            2341..3426
                     /gene="rmlB"
     CDS             2341..3426
                     /gene="rmlB"
                     /note="O039_02"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6 dehydratase"
                     /protein_id="BAQ00870.1"
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLA
                     DVSDSERYVFEHADICDAAAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARNYWSALDGDKKNSFRFHHISTDEVYGDLPHPDEVNNKEQLPLFTETTA
                     YAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KGLPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDL
                     LDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTVEWY
                     LANAKWVENVKSGAYQSWIEQNYEGRQ"
     gene            3426..4325
                     /gene="rmlD"
     CDS             3426..4325
                     /gene="rmlD"
                     /note="O039_03"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="BAQ00871.1"
                     /translation="MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPE
                     GVAETVKKIRPDVIVNAAAHTAVDKAESEPEFAQLLNATSVESIAKAANEVGAWVIHY
                     STDYVFPGTGEIPWLETDATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
                     NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRMALNKPEVAGLYHLVAT
                     GTTTWHDYAVLVFEEARKAGIPLALNKLKAVPTTAYPTPARRPHNSRLNTEKFQQNFA
                     LVLPDWQVGVKRMLNELLTTTAI"
     gene            4383..5261
                     /gene="rmlA"
     CDS             4383..5261
                     /gene="rmlA"
                     /note="O039_04"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="BAQ00872.1"
                     /translation="MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTL
                     MLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPTPDGLAQAFIIGEEFIGG
                     DDCALVLGDNIFYGHDLPKLMDTAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISL
                     EEKPLQPKSNYAVTGLYFYDNDVVEMAKNLKPSARGELEITDINRIYMEQGRLSVAMM
                     GRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAYRKGFIDAEQVKALAEPL
                     KKNAYGQYLLKMIKGY"
     gene            5266..5805
                     /gene="rmlC"
     CDS             5266..5805
                     /gene="rmlC"
                     /note="O039_05"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="BAQ00873.1"
                     /translation="MNVIKTEIPDVLIFEPKVFSDERGFFFESFNQKIFEEAVGRKVE
                     FVQDNHSKSRKGVLRGLHYQLEPYAQGKLVRCVVGEVFDVAVDIRKSSPTFGKWVGVN
                     LSAENKRQLWIPEGFAHGFLTLKDNTEILYKTTSYYSPEYERSIIWNDEDLVIKWPND
                     PCVISHKDSLAQSFAIIRN"
     gene            5816..6928
                     /gene="vioA"
     CDS             5816..6928
                     /gene="vioA"
                     /note="O039_06"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-6-deoxy-D-xylo-4-hexulose aminotransferase"
                     /protein_id="BAQ00874.1"
                     /translation="MSKKIPVTQPFLPELSEFIPFLEKIWENKWLTNNGPFHQQLERE
                     LCEFLNVKHISLFTNATIALVTALQALRVKGEVITTPYSFVATSHSILWNNLTPVFVD
                     IKEGGFNIDPKKIEEAITPNTTAIMPVHCYGYPCEVNEIQRIADNYGLKVIYDAAHAF
                     GINYGDESILNFGDLSILSFHATKVFNTFEGGAIICPDLKTKERIDRLKNFGFVDELT
                     VTAAGINGKMSEVNSAFGLLQLKYINEAIGKRSRIDSQYRNDLSNIEEIIIPAKSTES
                     NSNFSYFPILVQSESGFSRDGLYDHLKENGILSRKYFYPLISNMPMYKRNESSLVDNL
                     KNANETASKVLCLPIYASMNRDEYVYIISKVKEYFS"
     gene            6925..7506
                     /gene="vioB"
     CDS             6925..7506
                     /gene="vioB"
                     /note="O039_07"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-viosamine N-acetyltransferase"
                     /protein_id="BAQ00875.1"
                     /translation="MSYLTRDEIENFGFNKIGRNVLISDKTSIYNPQKISIGDNVRID
                     DFCILSAGDGGIEIGNYVHIASYSSLIGKEKIKLGDYSGLSSRVSIYSSSDDYSGLWM
                     TNPTVPSTFTNVVSKPVILEKHVIVGCGAVILPGVLIQEGAAIAALSLVKKSCEPFYI
                     YHGNPAKKIFARKKVIKNLERNLEEFDNLKCQK"
     gene            7494..8972
                     /gene="wzx"
     CDS             7494..8972
                     /gene="wzx"
                     /note="O039_08"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAQ00876.1"
                     /translation="MSKITKNIFANYLGVVITTALSFLVVPFYLKILGKDSFGLIGIA
                     SLIQGWVMLLNSGLAPVTGREAAKAYAIGNSWREAAIFFRTVDVFLISLSLIVFVIFY
                     ISRGWLSNVWIESSSLNSSTISLALCLLIAMTSIRLLTSITRGILANIDRQIWLNNNL
                     IIFSLLRFAASIPLLYAYPGINYLFIWWLFVSLLEYFSIQYKTWSIIPVKINFFIFDF
                     LSIKKRWKMIVALASTSLIWVLITNTDKLILSTYLSLESYGFYSIATLLSSSIIILAQ
                     PIAQAFQPKMTSAFTHGGIENAEMILREATKWIVYLIYPIVVILCLYPNQIIFVWTGD
                     SDAMQQAGDFLIGYTIGNIFIALGSILYAFQVSIGIVRKHLQGNIILCVCYLPLIPFI
                     VTKYGAIGISILWAIVNFIYFVLWNLHLLKKITKTLYPQWVLIETLLPLIMLFLIMTF
                     VRYFFVLDGQYSRFILFLLLCLLTCVAFVINLLNMKLLKYRN"
     CDS             8972..9913
                     /note="O039_09"
                     /gene="wfaS"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ00877.1"
                     /translation="MAMTKYAPITVYTYNRYDHFTKTIEALRNNYLAENSILYVVSDA
                     AANEKDENLVKKIRDYSKKISGFKSVELIFRKENLGPLQSIYGAEREIIDSHGRIISM
                     EDDNITSRNFLNFMNQGLERFEYEQSVYSICGYCPAVKRSTKELGDIWLYPWNISWGY
                     ATWKQKYDLLNPLINNYEQLKTEGILRRVNRMGGLYITDSLKRDYMKTAYFPDAILCC
                     NMTKLDMVSVIPSISKVFNIGNDGSGNSKGANTNKYDVLLDEGAKTIFDFNITKQSLS
                     AEMTKEVARFYNGRLVTRLARKIGIYDRLLSLKQNYG"
     CDS             9920..10963
                     /note="O039_10"
                     /gene="wccR"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ00878.1"
                     /translation="MALLIISPSLINGGHEFQSIEFINELYKTRKSIFVSCANSFFYE
                     NINISEEDKEIFEYPQGGIIDLFCSFNRVKKHLKTHIHGVTDVLICGGTIEVIIFYSH
                     IIKSIDKKIRVIGYVPMVVDKKILRPVLGTVQNYVLKILCGKVDEIITINKIQSYLFN
                     VFYNKKTLVLPNKLKKISCVTSDYGFRLIYCGRLDNVQKNIIELIFMLDRINNPVKEF
                     IIIGDGPDFQKILEISNKTRNIKVKIIGWASEEDINSILGINDILIMNSRWEGEPLVI
                     REFIDRNLPVISRDIPGVRGVTLRKYRYNNENELEEILNNHVGRFEVKKQIKEENIMR
                     MRSRVIAIITGRI"
     gene            10965..12212
                     /gene="wzy"
     CDS             10965..12212
                     /gene="wzy"
                     /note="O039_11"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAQ00879.1"
                     /translation="MFLFKKPKFIFLLLFIISNIYSCLYFINTGHLLGEVSDFNFKSE
                     ETSIYINLLIIFFYLFFLVVIFRFFSKIHVNSLLDNDCRIKWCKAEFFWGKLLIIIQI
                     LFIFYFCLTNTFGANSVNRDGGIISALWVVLSPDNLFFIYYSIFRKSRYAKYNLLLAI
                     LSNILRGWSGILIFIVFIELCYRYREGKLKIRLLSKICGIMFLLYPVILAVKYGIRDS
                     FLTNSNFWESFDRSWLYVFNNNGVLGYINGLLFGIEQFFSRIQLFSNAVVVYSLKHEL
                     ANFVITNKVTSYWQEGIYGIIWNRIFDLPTSYNLGEVLANFIDPQSIIGSWNSNPTFL
                     SWLFIDPFQIGIYLLFTIALCFITMFLVKKITSSTLSLDMLWYMWLILIMPGWFASLI
                     LFLNTLIIFYVITFIKLNVTIER"
     CDS             12218..13207
                     /note="O039_12"
                     /gene="wccS"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ00880.1"
                     /translation="MGKIVINLWHIKNTNGLFYYALDYIDHIAAEKIILLNVNFPNSE
                     AIERLSGNNKILKLSLLNYVMFMFKCFIEHNLIFTPSSHPIPFIKKQLVIVHDMYPFH
                     GFKGNLKKILFCISAKISRCKIGYINRSQVLPALLNLGINPRQLVFAPNKFPDLFSNP
                     LNRIPYDKKKIIVGLVGTDSDKKNYHELLSSIRHRKLHGQFNLMIYGHETPYFKRVNS
                     DFPDLNISLVKSDETSLRDFLTNINILISICRTEGFGRPIATALVNGVPCFLINCPVF
                     REFFSNSANVYPTTDELINAILEIKDIPINKAFIIPTDVKEAFFSIIDMINNG"
     CDS             13212..13991
                     /note="O039_13"
                     /gene="wdaS"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ00881.1"
                     /translation="MLYIAIVSHGHFEIINELNCISKLSALDDVQIIVKDNVGEIKLK
                     EYCKKYNIMYFDDKKGLGFGANNNFIFNKICHDANDNDYFLVMNPDVFIECDELLKFK
                     KNIDTNDYSCVTINLYKDYCYKQFDNAIRKFPTLLTFIKSFLFGINDSIEDKLSFDKI
                     QEIEWCAGSFIAFDIKTYRSLGGFDEKYFMYCEDIDLCWRVKYIINKKIYCLSDIKAI
                     HLARFNNRKMLSKHFFWHVKSIMIFLSKTYMSKYFRGQSNG"
     gene            13984..15414
                     /gene="manC"
     CDS             13984..15414
                     /gene="manC"
                     /note="O039_14"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ00882.1"
                     /translation="MAKYNINPVILCGGNGTRLWPLSRGLYPKQFLNLDDTSSMLEKT
                     INRLEGLDVSLPLVICNEQHRFIVAEQLRTLKKLNRNILLEPIGKNTAPALALAALYN
                     INFNSNSLLLVLAADHVINDNQSFVTSIKKAIPYAIEGKLVTFGIEPTKPETGYGYIK
                     KGNECSSIAIGDGYHVERFVEKPNFSSACDYISSGEYLWNSGMFLFEPHKYLSELRKY
                     QPDIYNACVDAFKYDLIDNDFIRVDPLSFSQSPSLSVDYAVMEKTSDAVVVPMNAEWS
                     DVGSWAALWEISNKDDDGNVLHGDVISLSTKNSYIYSESELVTTIGIENLAIVQTKDA
                     ILVSNLASTQDVKKLVEILQLNGRTEHYVHQERYRPWGKSDTIDTGDSYQVKMLTIMP
                     RENLSMQVHYKRAEHWVVLSGCARIVIDGFESILNENESVHIPVGVKHYLENIGNTPL
                     RIIEIRSGSYLEEDDIIRFSDNDGYV"
     gene            15418..16797
                     /gene="manB"
     CDS             15418..16797
                     /gene="manB"
                     /note="O039_15"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ00883.1"
                     /translation="MPKNRVITSFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTI
                     VLGGDVRLTSETLKLALARGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASH
                     NPMDYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVD
                     HLFGYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPN
                     GIPNPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEA
                     FLEKNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSA
                     HHYFRDFAYCDSGMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAQPVEA
                     INRVEQHFSREALAVDRTDGISMTFADWRFNLRSSNTEPVVRLNVESRGDVPLMKEKT
                     KLILELLNK"
     gene            16961..18367
                     /gene="gnd"
     CDS             16961..18367
                     /gene="gnd"
                     /note="O039_16"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ00884.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGKPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGKYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKEQRVAASKVLSGPQAQPAGDKGEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            18616..19782
                     /gene="ugd"
     CDS             18616..19782
                     /gene="ugd"
                     /note="O039_17"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ00885.1"
                     /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDQISP
                     IVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIK
                     DVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD"
     gene            19892..20905
                     /gene="wzz"
     CDS             19892..20905
                     /gene="wzz"
                     /note="O039_18"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ00886.1"
                     /translation="MRTWKFPSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQLWRGKM
                     TIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSD
                     LQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKL
                     AQYIQQVDDKVNQELEKDLKDNIALGRKNSQDSLRTQEVVAQEQKDLRIRQIQEALQY
                     ANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEAPRPLVFSSNYYQTRQNLLDI
                     ESLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNY
                     NAK"
     gene            complement(21000..21611)
                     /gene="hisI"
     CDS             complement(21000..21611)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAQ00887.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQNLDLTTVIENLRKRHQ"
BASE COUNT     6618 a   3964 c   4735 g   6623 t
ORIGIN
        1 acgccatctt acgccaggga tttcataacc agattatcgg tgccaacatc accaattgta
       61 agttcagcga cttacaaggc gacgccattg aatggaacgt ggcaattaac gaccgtgata
      121 ttttgatatc tgaccatgtc atcgagcgca tcaactgtac caacggcaaa atcaactggg
      181 gcatcggcat aggccttgcg ggaagcactt atgataacaa ctacccggaa gaccaggcag
      241 tgaaaaactt tgtcgtggcg aatatcacgg gatcggattg tcggcagttg atccatgttg
      301 aaaatggtaa acattttgtt attcgtaata tcaaagcccg caatatcacg ccggatttca
      361 gtaagaaagc gggtattgat aacgcgacag tcgctattta cggttgtgac aatttcgtga
      421 ttgataatat tgaaatgatt aatagcgccg ggatgttaat cggctatggg gtaattaaag
      481 gcaaatatct ctcgataccg caaaatttcc gagtgaataa tattcaactg gataacaccc
      541 accttgctta caaattgcgc ggcattcaaa tctccgccgg gaatgctctc tcctttgtgg
      601 cgctgactaa cattgagatg aagcgtgcgt cgctggagtt acacaacaaa ccgcaacatc
      661 tttttatgcg aaatatcaag gtgatgcagg aatcctcagt tggaccagca ttgagcatga
      721 acttcgacat gcgcaaagac gttcgtggcg tctttatggc gaaaaaagaa acactactgt
      781 cacttgcaaa tgttcatgcg gtgaatgaaa aagggcaaag ctccgtcgat atcgacagga
      841 ttaatcacca tattgttaat gtggaaaaga ttaactttag attgccagaa cggagggagt
      901 agatttgcga ccattcctgg aaaaatggag ccatacttag gaacaatgct actgcaatcc
      961 acaacgaagc ggcgtaacat caccagtaat tcagtaatca attcagggta attgatgctg
     1021 gcgaaaaaaa tcgaacaagc tataattcag caaccatttt acaggtggat gaaataatga
     1081 cgaatttaaa agcagttatt cctgtagcgg gtcttgggat gcatatgttg cctgccacta
     1141 aggcgatacc caaagagatg ctaccgatcg tcgacaagcc aatgattcag tacattgttg
     1201 acgagattgt ggctgcaggg atcaaagaaa tcctcctggt aactcatgcg tccaagaacg
     1261 cggtcgaaaa ccacttcgac acctcttatg aattagaatc tctccttgaa cagcgcgtaa
     1321 agcgtcaact gcttgcggaa gtgcagtcca tctgtccacc gggcgtgacc attatgaacg
     1381 tgcgtcaggg cgaaccttta ggtttgggtc actccatttt atgtgcacga cccgccattg
     1441 gtgacaaccc atttgtcgtg gtgctgccag acgttgttat cgatgacgcc agtgccgacc
     1501 cgctgcgcta caaccttgca gccatgattg cgcgcttcaa cgaaacgggc cgtagccagg
     1561 tgctggcaaa acgtatgccg ggtgacctct ctgaatactc cgtcattcag accaaagagc
     1621 cgctggaccg cgaaggtaaa gtcagccgca ttgttgaatt tatcgaaaaa ccggatcagc
     1681 cgcagacgct ggactcagac atcatggccg ttggtcgcta tgtgctttct gcagatattt
     1741 ggccggaact tgaacgcact cagcctggtg catgggggcg tattcagctg actgatgcca
     1801 tcgctgaact ggcgaaaaaa cagtccgttg atgccatgct gatgacaggt gacagctacg
     1861 actgcggtaa aaaaatgggt tatatgcagg cgtttgtgaa gtatggacta cgcaacctga
     1921 aagaaggagc gaagttccgc aaaggcattg agaaactgtt aagcgaataa tgaaaatctg
     1981 accgaatgta acggttgata agaaaattat aacggcagtg aagattcgtg gcgaaagtaa
     2041 ttgttgcgaa ttttcctgcc gttgttttat ataaacaatc agaataacaa cgagttagca
     2101 ataggatttt agtcaaagtt ttccaggatt ttccttgttt ccagagcgga ttggtaagac
     2161 aattagcgtt taaatttttc gggtttagcg cgagtgggta acgctcgcta catcgtaggc
     2221 atgcatgcag tgctctggta gctgtaaagc caggggcggt agcgtgcatt aatacctcta
     2281 ttaatcaaac tgagagccgc ttatttcaca gcatgctctg aagtaatatg gaataataaa
     2341 gtgaagatac ttgttactgg tggcgcagga tttattggtt ctgctgtagt tcgtcacatt
     2401 ataaataata ctcaggatag tgttgttaat gtcgataaat taacgtacgc cggaaacctg
     2461 gaatcacttg ctgatgtttc tgactctgaa cgctatgttt ttgaacatgc ggatatttgc
     2521 gatgctgctg caatggcgcg gatttttgct cagcatcagc cggatgcagt gatgcacctg
     2581 gctgctgaaa gccatgtgga tcgttcaatt acaggccctg cggcatttat tgaaaccaat
     2641 attgttggta cttatgtcct tttggaagcg gctcgcaatt actggtctgc tcttgatggc
     2701 gacaagaaaa atagcttccg ttttcatcat atttctactg acgaagtcta tggtgatttg
     2761 cctcatcctg acgaagtaaa taataaagaa caattacccc tctttactga gacgacagct
     2821 tacgcgccaa gtagcccata ttctgcttcg aaagcatcaa gcgatcattt agtccgcgct
     2881 tggaaacgta cctatggttt accgaccatt gtgactaatt gctctaacaa ttatggtcct
     2941 tatcatttcc cggaaaaatt gattccattg gttattctga atgctctgga aggtaaagga
     3001 ttacctattt atggtaaagg ggatcaaatt cgcgactggc tgtatgttga agatcatgcg
     3061 cgtgcgttat ataccgtcgt aaccgaaggt aaagcgggtg aaacttataa cattggtgga
     3121 cacaacgaaa agaaaaacat cgatgtagtg ctcactattt gtgatttgtt ggatgagatt
     3181 gtaccgaaag agaaatctta ccgcgagcaa attacttatg ttgccgatcg cccgggacac
     3241 gatcgccgtt atgcgattga tgcagagaag attagccgcg aattgggctg gaaaccgcag
     3301 gaaacgtttg agagcgggat tcgtaaaacg gtggaatggt acctggctaa tgcaaaatgg
     3361 gtcgagaatg tgaaaagtgg tgcctatcaa tcgtggattg aacagaacta tgagggccgc
     3421 cagtaatgaa tattctcctt ttcggcaaaa cagggcaggt aggttgggaa ctacagcgtg
     3481 ctctggcacc tttgggtaat ttgattgctc ttgatgttca ctccactgat tattgtggtg
     3541 attttagtaa tcctgaaggt gtggctgaaa ccgtcaaaaa aattcgccct gatgtaattg
     3601 ttaatgctgc ggctcatacc gcagtagata aggctgagtc agaacccgaa tttgcacaat
     3661 tactcaatgc gaccagcgtt gaatcaattg ccaaagcggc taatgaagtt ggggcctggg
     3721 taattcatta ctcaactgac tacgtatttc cgggaaccgg tgaaatacca tggctggaga
     3781 cggatgcaac cgcaccgcta aatgtttacg gtgaaaccaa gttagccgga gaaaaagcgt
     3841 tacaggaaca ttgcgcgaag catcttattt tccgtaccag ctgggtatac gcaggtaaag
     3901 gaaacaattt tgccaagaca atgttacgtc tggcaaaaga gcgcgaagaa ttagctgtta
     3961 ttaatgatca gtttggtgca ccaacaggtg ctgaactgct ggctgattgt acggcacatg
     4021 caattcgtat ggcactgaat aaaccagaag tcgcaggctt gtaccatctg gtagccactg
     4081 gtaccacaac ctggcacgat tatgctgtgc tggtttttga agaggcacga aaagcaggta
     4141 ttccccttgc actcaacaag ctcaaggcag taccaacaac agcctatcct acaccagctc
     4201 gtcgtccaca taactctcgc cttaatacag aaaaatttca gcaaaatttt gcgcttgttt
     4261 tgcctgactg gcaagttggc gtgaaacgca tgctcaacga attattaacg actacagcaa
     4321 tttaatagtt tttgcatctt gttcgtgatg atggagcaag atgaattaaa aggaatgatg
     4381 aaatgaaaac gcgtaaaggt attattttag cgggtggctc tggtactcgt ctttatcctg
     4441 tgactatggc tgtcagtaaa cagctattac ctatttatga taagccgatg atctattacc
     4501 cgctctctac actgatgttg gcgggtattc gcgatattct gattatcagt acgccacagg
     4561 atactcctcg ttttcaacaa ctgctgggtg acggtagcca gtgggggcta aatcttcagt
     4621 acaaagtgca accgactcca gatgggcttg cgcaggcgtt tattatcggt gaagagttta
     4681 tcggtggtga tgattgtgct ttggttctag gtgataatat cttttacggt cacgatctgc
     4741 cgaagttaat ggataccgct gttaacaaag aaagtggtgc aacggtattt gcctatcacg
     4801 ttaatgatcc tgaacgctat ggtgtcgttg agtttgataa aaacggtacg gcaataagcc
     4861 tggaagaaaa accgctacaa ccaaaaagta attatgcggt aaccgggctt tatttctatg
     4921 ataacgacgt tgtcgaaatg gcgaaaaacc ttaagccttc tgcccgtggt gaactggaaa
     4981 ttaccgatat taaccgtatt tatatggaac aggggcgttt atccgttgcc atgatggggc
     5041 gtggttatgc atggctggat acggggacac atcagagtct tattgaagca agcaacttca
     5101 ttgccaccat tgaagagcgc cagggactaa aggtttcctg cccagaagaa attgcttacc
     5161 gtaaagggtt tattgatgca gagcaggtga aagcattagc tgagccgctg aaaaaaaatg
     5221 cttatggcca gtatctgctg aaaatgatta aaggttatta ataaaatgaa cgtaattaaa
     5281 acagaaattc cagatgtact gatttttgaa ccgaaagttt ttagtgatga gcgtggtttc
     5341 tttttcgaga gctttaacca gaagattttt gaggaagctg taggccgcaa agttgaattt
     5401 gttcaagata accattcgaa gtccaggaaa ggtgttttac gcggattgca ttatcagtta
     5461 gaaccttatg cgcaaggaaa attggtacgc tgcgttgttg gtgaggtttt tgatgttgcg
     5521 gttgatattc gtaaatcatc acctactttt ggcaagtggg ttggggtgaa tttatctgct
     5581 gagaataagc gccagttgtg gatccctgaa ggatttgcgc atggattttt aaccttaaaa
     5641 gataatactg aaatattgta caagactaca agttattatt cacctgagta tgaaagatct
     5701 atcatatgga atgatgaaga tcttgtaatt aagtggccta atgacccttg tgtcatctcc
     5761 cataaagata gtttggcaca atcatttgct attattagaa attaatgagg aatatatgag
     5821 taagaagatt ccagttacac aaccatttct tcctgagtta tcggagttta taccattcct
     5881 agagaaaata tgggaaaata aatggttgac aaataatggt ccatttcacc aacaacttga
     5941 aagagaatta tgtgaatttc ttaacgttaa acatatatct ttatttacaa atgcgacaat
     6001 tgctcttgta acagcacttc aagccctaag agtgaaaggt gaagtgatta caactccata
     6061 ttcatttgtt gcaacctcac attctatatt atggaacaat cttacgccag tatttgtcga
     6121 tattaaagaa gggggattta atattgatcc taaaaaaata gaagaggcca taactccaaa
     6181 tacaacagct attatgcctg ttcattgtta tggttatcca tgcgaagtca atgaaattca
     6241 aaggattgct gataattatg gactaaaagt aatatacgat gcagctcatg cttttgggat
     6301 taattatggg gatgaaagta ttttaaattt tggcgatctt tcaattttaa gctttcatgc
     6361 aacaaaagtt tttaacacat ttgagggggg ggcgataata tgtcctgatc taaaaacaaa
     6421 agagagaata gatagattga aaaattttgg gtttgtagat gagttaacag tgactgcagc
     6481 tggaataaat gggaaaatga gcgaggtaaa ttcagcgttt ggattactcc agcttaaata
     6541 tataaatgaa gcaatcggaa aaagaagtag aattgattca caatacagaa atgatcttag
     6601 taatattgaa gaaatcataa ttcctgctaa aagtactgag agcaatagta atttttcgta
     6661 cttcccaatt ttagtccaat cagaatctgg tttcagtaga gatggactgt atgatcatct
     6721 taaagaaaat ggaatactct cgagaaaata tttttaccca ctaattagta atatgccgat
     6781 gtataagaga aacgaatctt ctcttgtaga taatttgaaa aatgcaaatg aaacagcatc
     6841 taaagtatta tgtttaccca tatatgcatc catgaataga gacgaatatg tctatataat
     6901 ttccaaagtg aaggagtatt tttcatgagt tatttaacaa gagatgagat tgaaaatttt
     6961 ggatttaata aaataggtag aaatgtatta atatcagata aaacctcgat atacaatcca
     7021 caaaaaatat caatcggtga taatgttagg attgacgatt tttgtatttt gtcagcaggt
     7081 gatggtggta tagaaattgg aaattatgtg catattgcat catattcgtc cttaataggg
     7141 aaggaaaaaa ttaaattagg agattatagc ggtctatctt cgcgtgtttc tatttattcc
     7201 agtagtgatg attattctgg actttggatg actaatccaa cggttccatc tacgtttacc
     7261 aatgttgttt caaaacctgt aattcttgag aagcatgtta ttgtaggctg tggagcagtt
     7321 atcttaccgg gagtacttat ccaagaaggt gctgcaattg cagcactttc acttgttaaa
     7381 aaatcgtgtg aaccttttta tatctatcat ggtaaccctg caaaaaaaat ttttgcgaga
     7441 aaaaaagtaa taaagaatct tgagagaaac cttgaagaat ttgataattt aaaatgtcaa
     7501 aaataactaa gaatatattc gcaaattatt taggggtggt gattaccacc gctctttctt
     7561 ttttagttgt accattttat ttaaagatat taggtaagga ttcctttggt ttaataggaa
     7621 tagcatcgct tattcagggc tgggtaatgt tgttaaattc aggattagcg cctgtaactg
     7681 gacgagaagc agcaaaagcc tatgctatag gtaattcttg gcgtgaagct gcaatatttt
     7741 tcagaacagt tgatgttttc ttaatatcat tgtcattaat tgtttttgta attttttata
     7801 tttcaagagg ttggttatca aatgtctgga tagaaagctc atcattaaat tcctctacta
     7861 taagtttggc attatgtctt cttattgcaa tgacgtcaat tcgactttta acaagtatta
     7921 cgagaggcat attggctaac atagataggc aaatatggtt aaataataat ttaattatat
     7981 ttagcttact tagatttgct gctagtattc cattgctata tgcctacccg ggcataaact
     8041 atctttttat atggtggcta tttgtatcac tacttgaata ttttagtatt cagtataaaa
     8101 catggtcaat aataccagtt aaaattaatt tttttatttt tgatttttta agtataaaaa
     8161 aacgctggaa aatgatagta gcattggcat caactagttt gatatgggtg ctgataacaa
     8221 atacggacaa attgattctg tctacatatc tctcgcttga gagttacggt ttttatagca
     8281 ttgcaacatt actttcaagt agtattatca tattagccca acctattgca caagcatttc
     8341 agccaaagat gacttcagct tttactcacg gaggtattga aaatgctgaa atgatcttaa
     8401 gggaagcaac taaatggatc gtttatctca tttatcctat cgttgttatt ctgtgtttat
     8461 atccaaatca aattatattt gtttggacag gagatagtga tgcaatgcag caggctggtg
     8521 attttctcat tgggtacaca ataggaaata tatttattgc ccttggttca atactatatg
     8581 cttttcaagt ctcaatcggt atagttagga aacatctaca ggggaatata atcttgtgtg
     8641 tttgctatct cccactaata ccatttattg taaccaaata tggagcgata ggtatatcta
     8701 tattatgggc gattgtgaat tttatatatt ttgttttatg gaacttacat ttgttaaaaa
     8761 aaatcacaaa aacactttac cctcagtggg ttcttattga aacattgctt ccattaataa
     8821 tgttattttt aataatgaca tttgtcaggt attttttcgt tctagacgga cagtattcaa
     8881 gatttattct atttttgttg ctctgtttat taacttgcgt ggcctttgta atcaaccttt
     8941 taaatatgaa gttattaaaa tataggaact aatggctatg acaaaatatg caccaattac
     9001 cgtttatacg tataatcgtt atgatcattt tactaaaaca attgaggcac tgcgtaataa
     9061 ttatttagcc gaaaactcta ttctatatgt ggtctcagat gctgctgcta atgaaaaaga
     9121 tgaaaattta gtaaaaaaaa tccgagacta ttcaaaaaaa atatcaggat ttaaatcggt
     9181 tgaattaatt tttagaaagg aaaatttagg tcctcttcaa agcatttatg gtgccgagcg
     9241 tgaaattatt gatagtcacg gaagaataat atcaatggaa gatgataata ttacatcaag
     9301 aaatttttta aactttatga atcaaggact tgaacgcttt gaatatgagc agtcagttta
     9361 ttcaatttgt ggctattgcc cagcagttaa acgctctact aaagagcttg gtgatatttg
     9421 gttgtatcct tggaatatat cttggggata tgctacttgg aaacaaaaat acgatcttct
     9481 aaatccactt attaataatt atgaacaatt aaagacagag gggattttaa gaagagttaa
     9541 tagaatgggg gggttatata ttacagactc tctaaaaaga gattatatga agacagcata
     9601 tttccccgat gcaatattat gctgtaatat gactaagtta gatatggttt ccgttatccc
     9661 ttccatttcg aaagttttta acattggaaa tgatggttcg gggaatagta aaggtgctaa
     9721 tactaataaa tacgatgttc tgctggatga aggagctaaa actatatttg atttcaatat
     9781 cacaaaacaa tcactttccg ctgaaatgac taaagaagtt gcaagatttt ataatgggag
     9841 actagtgaca agactagcaa gaaaaattgg catatatgat cgtcttttat cattaaaaca
     9901 aaattatgga taataaatta tggctttatt gataatttca cctagtctaa taaatggcgg
     9961 gcacgaattt cagagtattg agtttataaa cgaactatat aaaacgagaa aatcaatttt
    10021 tgttagttgt gcaaatagtt ttttttacga aaatattaat atttcagaag aagataaaga
    10081 aatatttgaa tatcctcaag gcgggattat tgatttattc tgcagtttta atagggtgaa
    10141 aaaacatctc aaaacacata tccatggcgt aaccgatgtt ttaatttgtg gaggaacaat
    10201 agaagtaatt attttttatt cacatataat aaaatctatt gataaaaaaa ttagggtaat
    10261 tggttatgta ccaatggtag ttgataaaaa aattctcagg ccagtgttag gtacagtgca
    10321 aaattatgta ttaaaaattt tatgtggtaa agttgatgaa ataatcacaa ttaacaagat
    10381 tcaatcatat ttgtttaatg ttttttataa taaaaaaaca cttgtattac ctaataagct
    10441 gaaaaaaatt agttgtgtta caagtgatta tggctttcga ctaatatatt gtggaaggct
    10501 agataatgtt cagaaaaaca taatagaact aatctttatg cttgatagga taaataatcc
    10561 tgttaaagaa tttattatca tcggtgatgg ccccgatttc caaaaaatat tagagataag
    10621 taataagaca aggaatatta aagttaaaat tattggatgg gctagtgagg aggatataaa
    10681 ttcgattctt ggaataaatg atattttgat catgaattct agatgggagg gggaacctct
    10741 tgttattaga gaatttattg ataggaacct tcctgtcatt tcacgtgata tacccggagt
    10801 tcgtggtgtt actttaagaa aatatagata taataatgaa aatgaacttg aggaaatttt
    10861 aaataatcat gttgggagat ttgaagtaaa aaaacaaata aaagaagaaa atattatgag
    10921 gatgcgttct agggtaattg ctattattac aggtaggata tgaaatgttt ctctttaaga
    10981 aacctaaatt tatattttta ttacttttca ttatatcaaa catttactca tgtttatatt
    11041 ttattaacac cgggcatttg ttaggagaag tttctgactt taatttcaaa agtgaagaaa
    11101 catctattta tataaatttg cttattatat ttttttatct ttttttcttg gtcgttattt
    11161 ttaggttttt ttctaaaata catgtaaatt ctttattgga taacgattgc agaataaaat
    11221 ggtgtaaagc agagtttttc tgggggaagt tattaataat aattcagatt ttgtttattt
    11281 tttatttttg cttaacaaac acatttggcg caaatagcgt taatagagat ggtggcataa
    11341 tatcagcttt atgggttgta ttatcaccag acaatctttt ttttatctat tacagcatat
    11401 ttaggaaaag tagatatgct aaatataatt tattgctcgc gattctttct aatatattga
    11461 ggggatggag cggaatactg atttttattg tttttatcga attatgttat agatatcggg
    11521 agggaaaatt aaaaataagg cttctctcga agatttgtgg gataatgttc ctactgtatc
    11581 ctgtgatatt ggctgttaag tatggcattc gtgattcatt tttgactaac agcaattttt
    11641 gggaaagttt tgacagatct tggttatatg tatttaacaa taatggtgtg ttaggataca
    11701 tcaatggtct tttgtttgga attgaacaat tttttagtag aatacaactt ttttcgaatg
    11761 cagttgttgt ttattctttg aaacatgaat tagccaattt tgttatcacc aataaagtaa
    11821 cgagttattg gcaagagggt atttatggta ttatctggaa taggatattt gatttaccaa
    11881 cgagttataa cttgggcgaa gtattggcaa atttcattga tccacaaagt atcataggaa
    11941 gctggaattc taacccaaca tttttatctt ggctgtttat tgatccattt cagataggaa
    12001 tctatctatt atttacaatt gcgctttgtt ttataactat gtttttagta aaaaaaataa
    12061 catcgtcaac tttgtcgcta gatatgctct ggtatatgtg gctgatcctt attatgcccg
    12121 gttggtttgc ttcattaata ttatttctta atactttaat aattttttat gttattacat
    12181 ttataaaatt aaacgtaaca atagagaggt agttgtagtg gggaaaatag ttataaatct
    12241 ttggcatata aaaaatacta atggcttatt ttattatgcc ttggattata ttgatcatat
    12301 tgctgcagaa aaaataattt tattaaatgt taactttcca aattctgaag ctattgaacg
    12361 actgagtgga aataataaaa tattaaagct gagtttgtta aactatgtca tgtttatgtt
    12421 taaatgtttt atcgaacata atttaatttt tactcctagc tctcatccca ttccttttat
    12481 aaaaaaacag ttagttattg tgcatgacat gtatcctttt catggcttta aagggaacct
    12541 aaaaaaaata ttgttctgta tttctgcgaa aatatctcga tgtaaaattg gttatataaa
    12601 tagatctcaa gttttacctg cattactcaa cttgggaatt aatcccaggc aacttgtatt
    12661 tgctccaaac aaatttcctg atttattctc aaatccttta aatagaattc catatgataa
    12721 gaaaaaaatt attgtggggc tagtgggtac agattcagat aaaaagaact accatgaact
    12781 tttaagctca attcgtcata ggaaattgca tggacagttt aatctcatga tctatgggca
    12841 tgagactcct tacttcaaac gcgtaaatag tgactttcct gatctaaata tttcattagt
    12901 aaaaagtgat gaaacgtcat taagagattt tttaactaat attaatatat taatatctat
    12961 atgtagaaca gaaggatttg gcagacctat tgctacagcg cttgttaatg gggttccatg
    13021 cttcttaatc aactgtcctg tttttagaga atttttttca aatagtgcca atgtttatcc
    13081 aacgactgat gaacttatta atgccatcct cgaaataaaa gatattccga taaacaaagc
    13141 cttcattata ccaactgatg ttaaagaagc atttttcagc atcatagata tgataaataa
    13201 cggataaaaa tatgctttat attgctattg tatctcatgg gcattttgag attattaatg
    13261 aactcaattg catttcaaag ttatctgctt tagacgatgt tcagataata gtaaaagata
    13321 atgtgggaga gataaaactt aaagaatatt gtaaaaaata taatatcatg tattttgatg
    13381 ataaaaaggg attaggcttt ggtgcgaata ataattttat ttttaataaa atatgtcatg
    13441 atgctaatga taatgactac tttttagtaa tgaatccaga tgtatttatt gaatgtgatg
    13501 aattattgaa atttaaaaaa aatatagata ctaatgatta ttcttgtgtg accataaatt
    13561 tatataaaga ttattgttat aaacaatttg acaacgcaat aagaaaattc cccactttat
    13621 taactttcat taagtcattt ttatttggaa ttaatgatag tatagaggat aaattatctt
    13681 ttgataaaat acaagaaatc gagtggtgtg ctggctcttt tatcgcattt gatattaaaa
    13741 catatcgatc attgggagga tttgatgaaa aatattttat gtattgtgag gatatagatc
    13801 tttgctggcg tgtgaaatat atcataaata aaaaaatata ttgtctgtct gatattaaag
    13861 ccattcatct tgctcgtttt aataaccgga aaatgctttc caagcatttc ttttggcacg
    13921 ttaaaagtat aatgattttt ttatcaaaaa cttatatgtc aaaatatttt agagggcaat
    13981 caaatggcta aatataatat aaacccagtt atactgtgtg gagggaatgg tactcgatta
    14041 tggccacttt cacggggttt atatcctaag cagtttctga atcttgatga tacatcatca
    14101 atgctagaga aaacaattaa tagattagaa ggtttggatg tttcccttcc cttggtaata
    14161 tgtaatgagc aacatcgttt tatcgtagcg gaacaactgc gaaccttaaa gaaattaaat
    14221 agaaatattc ttctggagcc aattggtaaa aatacggcac cagctctagc tcttgctgct
    14281 ctttataata tcaactttaa tagtaatagt ttgcttttag ttcttgctgc agatcatgtt
    14341 ataaacgata accaaagttt tgtaacttca attaaaaaag ctatacccta tgctattgag
    14401 ggtaaactag ttacctttgg tattgaacct acaaaaccag aaactggata tggatatata
    14461 aaaaagggaa atgaatgttc ctctatagct attggtgatg gttatcatgt tgaacgtttt
    14521 gtggagaagc cgaatttctc aagtgcatgt gattacatta gttctggtga atatctatgg
    14581 aatagtggca tgtttttatt tgagcctcat aaatacttat cagaattgag gaaatatcag
    14641 cctgatattt acaatgcctg tgtcgatgca tttaaatatg atctaatcga taacgacttc
    14701 attcgcgttg atccactatc attttcccaa agtcctagct tatcagttga ttatgcagta
    14761 atggaaaaga catcagatgc agttgtagta cctatgaatg ctgaatggag cgatgttggt
    14821 tcttgggctg cattatggga aataagcaac aaagatgatg atggtaatgt tttgcatgga
    14881 gatgtaatta gtttgtcgac caagaatagt tacatatact cagaatctga gttggtaaca
    14941 actattggca ttgaaaattt ggctattgtt cagacaaaag atgctatttt ggtttcgaat
    15001 cttgcatcta ctcaagatgt aaaaaaatta gttgagatat tgcagttaaa tggtcgtact
    15061 gagcattatg ttcaccaaga aagatatagg ccttggggga aatcagatac aatagatacg
    15121 ggggattctt atcaagttaa aatgctaaca ataatgccac gtgaaaattt atcaatgcag
    15181 gtacattaca aacgcgccga gcattgggtt gtactttctg gttgtgctag gatagtcatt
    15241 gatggttttg aaagtatttt aaatgaaaat gagtctgtgc atattcctgt aggtgtaaaa
    15301 cattatttag aaaatattgg taatacgcct ctcagaatta ttgagatacg ttctggttct
    15361 tatttagaag aagatgatat tatcaggttt tctgacaatg atggatatgt ttaacttatg
    15421 cccaaaaata gagtaataac tagttttaaa gcctatgata ttcgcggaaa actaggcgaa
    15481 gaactgaatg aagatatcgc ctggcgcatt ggtcgcgcct atggcgaatt tctcaaaccg
    15541 aaaactattg tgttaggcgg tgatgtccgc ctcaccagcg aaaccttaaa actggcgctg
    15601 gcgagaggtt tacaggatgc gggcgtcgat gtgctggata tcggcatgtc cggcaccgaa
    15661 gagatctatt tcgccacgtt ccatctcggc gtggatggcg gcattgaagt tactgccagc
    15721 cataatccga tggattataa cggcatgaag ctggtgcgcg agggggcccg cccgatcagc
    15781 ggggataccg gactgcgcga cgtccagcgt ctggctgaag ccaacgactt tcctcccgtc
    15841 gatgaaacca aacgcggtcg ctatcagcaa atcaacctgc gtgacgctta cgttgatcac
    15901 ctgttcggtt atatcaacgt caaaaacctc acgccgctca agctggtgat taactccggg
    15961 aacggcgcag cgggtccggt ggtggacgcc attgaagccc gctttaaagc cctcggcgca
    16021 cccgtggaat taatcaaagt gcacaacacg ccggacggca atttccccaa cggtattcct
    16081 aacccgctac tgccggaatg tcgcgacgac acccgcaatg cggtcatcaa acacggcgcg
    16141 gatatgggca ttgcctttga tggcgatttt gaccgctgct tcctgtttga cgaaaaaggg
    16201 cagtttatcg agggctacta cattgtcggt ttgctggcag aagcgttcct cgaaaaaaat
    16261 cccggcgcga agatcatcca cgatccacgt ctctcctgga ataccgttga tgtggtgact
    16321 gccgcaggcg gcacgccggt gatgtcgaaa accggacacg cctttattaa agaacggatg
    16381 cgcaaggaag acgccatcta cggtggcgaa atgagcgccc accattactt ccgtgatttc
    16441 gcttactgcg acagcggcat gatcccgtgg ctgctggtgg ccgaactggt gtgtctgaaa
    16501 ggaaaaacgc tgggcgaact ggtgcgcgac cggatggcag cgtttccggc aagcggtgag
    16561 atcaacagca aactggcgca acccgttgag gcgattaacc gcgtcgaaca gcactttagc
    16621 cgcgaggcgc tggcggtgga tcgcaccgat ggcatcagca tgacctttgc cgactggcgc
    16681 tttaacctgc gctcctccaa caccgaaccg gtggtgcgcc tgaatgtgga atcgcgcggt
    16741 gatgtgccgc tgatgaaaga aaagacaaaa cttatccttg agttactgaa taagtaattg
    16801 agtaaattca tataaatagg ttttaaaaga cagaaaagat gagatattca gtgtggtata
    16861 gcaaaggtaa tgctattcac catctctatg agtgagttaa catctatacc acatttaagc
    16921 cgcacactcg gcggtgacca ccccctgaca ggagtaaaca atgtcaaagc aacagatcgg
    16981 cgtagtcggt atggcagtga tggggcgcaa ccttgcgctc aacatcgaaa gccgtggtta
    17041 taccgtctct attttcaacc gttcccgtga aaagacggaa gaagtgattg ccgaaaatcc
    17101 aggcaagaag ctggttcctt actatacggt gaaagagttt gttgaatctc tggaaacgcc
    17161 tcgtcgcatc ctgttaatgg tgaaagcagg tgctggcacg gatgctgcta ttgattccct
    17221 caagccatac ctcgataaag gtgacatcat cattgatggt ggtaatacct tcttccagga
    17281 caccattcgc cgtaaccgtg agctttctgc cgaaggcttt aacttcatcg gtaccggtgt
    17341 ttccggtggt gaagagggcg cgttgaaagg tccttccatt atgcctggtg gccagaaaga
    17401 agcctatgaa ctggttgctc cgatcctgac caaaatcgcc gccgttgctg aagatggcaa
    17461 accgtgcgtt acctatattg gtgccgatgg cgcgggtcac tatgtaaaaa tggttcacaa
    17521 cggtattgaa tacggtgata tgcaactgat tgctgaagcc tattctctcc tgaaaggcgg
    17581 cctgaatctc tctaacgaag aactggcgca gacctttacc gagtggaata acggtgaact
    17641 gagcagctac ctgatcgaca tcaccaaaga tatcttcact aaaaaagatg aagacggtaa
    17701 gtacctggtt gatgtgatcc tggatgaagc ggctaacaaa ggtaccggta aatggaccag
    17761 ccagagcgcg ctggatctcg gcgaaccgct gtcgctgatt accgagtctg tgtttgcacg
    17821 ttatatctct tctctgaaag agcagcgtgt tgccgcatct aaagttctct ctggcccgca
    17881 agcgcagcca gctggcgaca aaggtgagtt catcgaaaaa gttcgtcgtg ctctgtatct
    17941 gggcaaaatc gtttcttacg ctcagggctt ctctcagctg cgtgcggcgt ctgaagagta
    18001 caactgggat ctgaactacg gcgaaatcgc gaaaattttc cgtgctggct gcatcatccg
    18061 tgcgcagttc ctgcagaaaa tcaccgatgc ttatgccgaa aatccgcaga tcgctaacct
    18121 gctgctggct ccgtacttca agcaaattgc cgatgactac cagcaggcgc tgcgtgatgt
    18181 cgttgcttat gcagtacaga acggtatccc ggttccgacc ttcgcggctg cggttgccta
    18241 ttatgacagc taccgcgccg cagttctgcc tgcaaacctg atccaggcac agcgtgacta
    18301 tttcggtgcg catacttata agcgcattga taaagaaggt gtgttccata ctgaatggct
    18361 ggattaatct gatttaacca acaataaaat tgaggcccgg cgtatattgc accgggcttt
    18421 tttttgccaa atatcttata gactaaattt cactgcttaa tattaactta ataaatatca
    18481 gctattctta taaagaaaat ctgaattgtt tttcgttgcg ttgaccatcg aacaacgtag
    18541 cgttaaaact tttagctctt atcaggatgc taaaaacatc atgattcaca gttaagttaa
    18601 ttctgagagc atgaaatgaa aatcaccatt tccggtactg gctatgtagg cttgtcaaac
    18661 gggcttctaa tcgctcaaaa tcatgaggtt gtggcattag atattttacc gtcacgcgtt
    18721 gctatgctga atgatcagat atctcctatt gttgataagg aaattcagca gtttttgcaa
    18781 tcagataaaa tacactttaa tgccacatta gataaaaatg aagcctaccg ggatgctgat
    18841 tatgtcatca tcgccactcc aaccgactat gatcctaaaa ctaattattt caatacatcc
    18901 agtgtagaat cagtaattaa agacgtagtt gagataaatc cttatgcggt tatggtcatc
    18961 aaatcaacgg ttcccgttgg ttttaccgca gcgatgcata agaaatatcg tactgaaaat
    19021 attattttct ctccggaatt cctccgcgaa ggtaaagccc tttacgataa tctccatccg
    19081 tcacgtattg tcatcggtga gcgttcagaa cgcgcagaac gttttgctgc gttgttacag
    19141 gaaggcgcga ttaagcaaaa tatcccgacc ctgtttaccg actccactga agcagaagcg
    19201 attaaacttt tcgctaatac ctatctggcg atgcgcgtag catactttaa tgaactggat
    19261 agctatgcag aaagtttagg tctgaatact cgccagatta tcgaaggcgt ttgtctcgat
    19321 ccgcgtattg gcaaccatta caacaacccg tcgtttggct atggtggtta ttgtctgccg
    19381 aaagatacca agcagttact ggcgaactac cagtctgtgc cgaataacct gatttcggca
    19441 attgtcgatg caaaccgcac gcgtaaagat tttattgccg atgccatttt gtcacgcaag
    19501 ccgcaagtgg taggtattta tcgtctgatt atgaagagcg gttcagataa cttccgtgcg
    19561 tcttctattc aggggattat gaagcgtatc aaggcgaaag gtgttgaagt aatcatctac
    19621 gagccagtga tgaaagaaga ctcattcttc aactctcgcc tggaacgtga tctcgccacc
    19681 ttcaaacaac aagccgacgt cattatctct aaccgaatgg cagaagagct taaagatgtg
    19741 gcagataagg tatacacccg cgatctcttt ggcagcgact aacatcttgt tatcagggct
    19801 atttacgccc tgattgtctt ttgttacctc cgcaataatt cattattttt atcgcttatc
    19861 ctatagcatt cacggggatt atcgctaaac tatgcggact tggaaatttc cgtcagttag
    19921 ggtaatgatg agagtcgaaa ataataatgt ttctgggcaa aaccatgacc cggaacagat
    19981 tgatttgatt gatttactag tgcagttgtg gcgtggcaag atgacaatca tcatttccgt
    20041 cattgtggct attgccctgg ctattggata tttggcagta gcgaaggaga aatggacgtc
    20101 aacagcaatt atcactcagc ccgacgtggg gcaaattgct ggctataaca atgccatgaa
    20161 tgttatctat ggtcaggctg cgccgaaagt atcggattta caggaaacgt tgattggtcg
    20221 cttcagttct gccttctctg cattagcaga aacgctggat aatcaggaag agccagaaaa
    20281 gcttaccatc gaaccttctg ttaagaacca gcaattacca ttgactgttt cttatgttgg
    20341 gcaaactgca gagggcgcac aaatgaagtt ggcccaatac attcagcaag ttgacgataa
    20401 agtgaatcaa gagctagaaa aggatctcaa ggacaacatt gctctgggac ggaaaaactc
    20461 gcaggactct ttaagaacgc aggaagtggt tgcgcaggag cagaaagatc tgcgtatccg
    20521 tcagattcag gaagcgttgc agtatgcgaa tcaggcgcag gtgacaaagc cacaggttca
    20581 gcagactgaa gatgtgacgc aagatacgtt gttccttttg gggagcgaag cgctggagtc
    20641 gatgattaag catgaggcgc cccgtccgtt ggtgttctca tcaaattact atcagactcg
    20701 tcaaaacctg ctggatatcg aaagcttaaa agttgatgat cttgatattc atgcttaccg
    20761 ctatgtgatg aaaccgacgt tacctattcg tcgcgatagc ccgaaaaagg caattacctt
    20821 gattctggcg gtgctgctgg gcggcatggt tggcgcgggg attgtgttgg ggcgtaacgc
    20881 tctgcgtaat tacaacgcga agtaatcttt tcggttttaa agaaaatggg cagggtggtg
    20941 acaccttgcc cgttttttgc cggatgcgac aacaatatcg catccgctta ccgcgcaact
    21001 cactgatgcc gtttacgcag gttctcaatt accgtcgtta aatccagatt ctgatcctgc
    21061 aacaacacca gcaggtgata catcaaatca gatgcctcgt tggtcagttc aaagcggtca
    21121 tgtaccgttg ctgccagtgc ggtttccacc ccttcttcgc ccactttctg cgcaatacgt
    21181 ttggtgccgc tggcatacag tttggctgtg taagaggttt ccgggtcggc agatttgcgt
    21241 tcggcgagca attgttcgag ttgatacagg aacagccact ggtgagcggt gtcgccgaag
    21301 cagctgctgg tgcctttgtg gcaggttggc ccgatgggat tcgccagcac cagtaacgtg
    21361 tcgttgtcgc agtccggcgc aatactcacc acattgagga aattgcccga cgtttcgcct
    21421 ttggtccaca gccgttgttt agtgcgcgag aagaaggtga ctttgccgct ttcgatggtt
    21481 ttgtctaagg cttccgggtt catatagccc agcattaaca cttcaccgga taccgcgtgc
    21541 tgcacaatca ccggcatcag tccgtcggtt ttttcccagt ccagttcgcg acgttgttgt
    21601 tctgttaaca tatcctgatc tccacgccct gtgttgccag gtacgctttt aattcaccaa
    21661 tattgattat ttgtttgtgg aatacggaag ctgccagcgc gccgtcaacg tcggcatcgc
    21721 ggaaggcttc gaggaagtgt tccatggtcc ccgcgccacc ggaggcaatc agtgggacgt
    21781 ggcaaacttc acgcactttt ttcagttgtt cgaggtcgta accgttacgc acgccgtcct
    21841 gattcatcat gttgaggacg atttctccgg caccgcgttt ttgcacttcc tctacccagt
    21901 cgagcgtttc ccactgagtg acgcgggtgc ggctttcatc
//
