LOCUS       AB812032               21073 bp    DNA     linear   BCT 13-MAY-2015
DEFINITION  Escherichia coli genes for O-antigen biosynthetic locus, partial
            sequence, strain: E71.
ACCESSION   AB812032
VERSION     AB812032.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M.,
            Hayashi,T. and Thomson,N.R.
  TITLE     A complete view of the genetic diversity of the Escherichia coli
            O-antigen biosynthesis gene cluster
  JOURNAL   DNA Res. 22 (1), 101-107 (2015)
   PUBMED   25428893
  REMARK    DOI:10.1093/dnares/dsu043
REFERENCE   2  (bases 1 to 21073)
  AUTHORS   Iguchi,A., Iyoda,S. and Ohnishi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2013) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..21073
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="E71"
                     /db_xref="taxon:562"
                     /note="serogroup:O80"
     gene            <1..891
                     /gene="wcaM"
     CDS             <1..891
                     /gene="wcaM"
                     /codon_start=1
                     /transl_table=11
                     /product="colanic acid biosynthesis protein"
                     /protein_id="BAQ01226.1"
                     /translation="RQGFHNQIIGANITNCKFSDLQGDAIEWNVAINDSDILISDHVI
                     ERINCTNGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKHF
                     VIRNIKARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYL
                     SIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELYNKPQHLF
                     MRNINVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNEKGQSSVDIDR
                     VNHHIVNVEKINFRLPERRE"
     gene            1054..1959
                     /gene="galF"
     CDS             1054..1959
                     /gene="galF"
                     /note="O080_01"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAQ01227.1"
                     /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYI
                     VDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVT
                     IMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNE
                     TGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGR
                     YVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQA
                     FVKYGLRNLKEGAKFRKGIEKLLSE"
     CDS             2288..3301
                     /note="O080_02"
                     /gene="gne"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-glucose 4-epimerase"
                     /protein_id="BAQ01228.1"
                     /translation="MILVTGGAGYVGSHTVLALLNQGINVTVIDNLSNSSIEAIRRIE
                     KISNKKVNFVHGDINNRAIIDRVFGDHKIKAVMHFAALKSVSESVKKPLNYYQNNVSG
                     TITLLEAMQKAGVNNFIFSSSATVYGSSSGPNIESDEIGNTTNPYGTSKYFIERILED
                     YCKSNKSFSAISLRYFNPTGAHKSAKIGEDPNGIPNNLIPYISHVASGKLDYLNVYGN
                     DYDTIDGTGMRDYIHVVDLADGHIKALEYMLTNKIGYDIFNLGTGKAYSVLQVIQAFE
                     KISMKKISYRVVSRRDGDLAKSWANTDKANKILNWKAKYDLEEMLQDVWNWQSKNPNG
                     YQR"
     gene            3632..4750
                     /gene="gmd"
     CDS             3632..4750
                     /gene="gmd"
                     /note="O080_03"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="BAQ01229.1"
                     /translation="MTKVALITGITGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERV
                     DHIYQDPHSCNPKLHLHYGDLTDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYT
                     ADVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVA
                     KLYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCLYL
                     GNMDSLRDWGHAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRF
                     EGTGVEEKGIVVSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWK
                     PEITLREMVSEMVANDLEAAKKHSLLKSHGFNVSLSQE"
     gene            4754..5719
                     /gene="fcl"
     CDS             4754..5719
                     /gene="fcl"
                     /note="O080_04"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-L-fucose synthetase"
                     /protein_id="BAQ01230.1"
                     /translation="MSLQRIFIAGHRGMVGSAITRQLEQRGDVELVLRTRDELNLLDS
                     RAVHDFFASESIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKL
                     LFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRS
                     VMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMA
                     AASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASK
                     PDGTPRKLLDVTRLHQLGWYHEISLEAGLASTYQWFLENQDRFRG"
     gene            5719..6222
                     /gene="gmm"
     CDS             5719..6222
                     /gene="gmm"
                     /note="O080_05"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosyl hydrolase"
                     /protein_id="BAQ01231.1"
                     /translation="MMFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQG
                     YWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTH
                     YVVLAFRFRVAEEELLLPDEQHDDYRWLTPDALLASDDVHVNSRVYFNNDPRAVIGLN
                     KKEVKNV"
     gene            6215..7663
                     /gene="manC"
     CDS             6215..7663
                     /gene="manC"
                     /note="O080_06"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAQ01232.1"
                     /translation="MSEVPLIAVVMAGGTGSRLWPLSREHYPKQFLQLSGESSLLQST
                     LLRLSTLSCETPLVITNEQHRFVVAEQLRQIDQLRDNIILEPCGRNTAPAIALSAFTA
                     LKRNEQQDPILLILAADHIIRKADIFCEAIQKSKTVAEQGYIVTFGIIPEYAETGYGY
                     IEKGEPFKNSPNITDDKFFHVQQFVEKPNHSKAEEYVSTGEYLWNSGMFMFKASVYLQ
                     ELKKHRPDIYEICEYTASLSYNDLDFIRLPKHIFQDCPSESIDFAVMEKTKNCIVRPV
                     DIGWSDVGSWHSLWEISDKTQDGDVCKGDILTYNTKNNYIYSESALVAAVGVEDIVIV
                     QTKDAILVSKKTEVQDVKKIVEMLKKHERSEYISHREEFRPWGKFDAIDQGERYKVKK
                     IVVKPGEGLSLRMHHHRSEHWIVLSGTAKVTLNDKTVLLAANESIYIPLGATYSLENP
                     GIIPLNLIEVSSGDYLGEDDIVRQKERYRIDD"
     gene            7667..9040
                     /gene="manB"
     CDS             7667..9040
                     /gene="manB"
                     /note="O080_07"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAQ01233.1"
                     /translation="MKKLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLG
                     GDVRLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM
                     DYNGMKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLF
                     GYINVKNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIP
                     NPLLPECRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE
                     KNPGAKIIHDPRLSWNTVDVVTAAGGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHY
                     FRDFAYCDSGMIPWLLVAELVCLKGKTLGGLVRDRMAAFPASGEINRKLAQPVEAINR
                     VEQHFSREALAVDHTDGISMTFADWRFNLRSSNTEPVVRLNVESKAAPKLMEEKTELL
                     LKILMRD"
     gene            9068..10288
                     /gene="wzx"
     CDS             9068..10288
                     /gene="wzx"
                     /note="O080_08"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAQ01234.1"
                     /translation="MSKFIILFARGYEVLIAFCLLKLMSDFLSPLEYAQLNLFVAITQ
                     GIALFFISPLQNWILVNNDNIACEIGLNSTILFEFIYSSAISVVACLLLIISGTHHEL
                     INAGILYLFILAVITPVLSQTVIPILNLQGKIIQFAGLSILGATLGIIIPVSFVSLYK
                     DDFEAWLLGGVIAQLLVIIIGLFIGNHSQSLGLFLGLKKIPYRKIFVFSLPLCVAIGF
                     QWYNAQGFRLSLQTVVDLKTLGAFIMGFGFGGKFLNAIEKVFSTVLLPQLYNRKKDSS
                     IKKEWLIYIFKMSAIYSVATFVIILLSQKIYPIIISEKYAEGQKYIVAGVIFDMFRCM
                     QNAVYQYNLIVSKNHIQLIMNMCITLFVFAFIYFINKYQLEFSYFVMMLPVVMGAITL
                     ISFIRNYMDEYENS"
     CDS             10269..11111
                     /note="O080_09"
                     /gene="werA"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01235.1"
                     /translation="MNMKIVNIYGGLGNALFQVAFALYLSDIGHNVKIDTLGLTAEFR
                     NKLRYFLKACNININECSYEERLRSSIILSRRQVKHKELLLLKFLFPQKIYKEIIWGE
                     LPSCEHNYYYGYFQNYELALKYAKIFSKGLNKIANENNFERPFTQDVFVHLRGGDYQT
                     AHAVKVHGLLDEKYYSEAFKFFESQPKRVFTNDKRYASKILGKNIFEYSEGIDFIYPD
                     IADMYLMSRYANGIIANSTFSFWSAILGDNGDKKIICPIKWFADERLQKESFKIKPPH
                     WIER"
     CDS             11096..12070
                     /note="O080_10"
                     /gene="werB"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01236.1"
                     /translation="MDRKMKKVSVLIASYNCAQFIGDTLHSLCSQTMNKDDYEIIIVD
                     DGSTDDSVNIINSLIKEQKNVIFRSRTTNLGVIKTRNELLLLAKGRSEYIAWCDSDDI
                     YNKDKLLRQYTYIKKKKLIGCGTWYKKFGLHDKRIIKFLNPEANRFFLLFGTPVGFPT
                     FMHKNNLDVFFDETLSSSEDYDYLSKICQLGDIGNIPKFYTYYRTHLKQESLGNHSRQ
                     RIMHVHLSQKIYNAYFADKIDEQNWIDFPSVLDLRDVKQIIELQNKYFTLFGEVFCAI
                     VDYRFILLNKNKPRCLMYYFIKRNFKLLYIFKLFRGKNVDVSVFNNSR"
     CDS             12036..13982
                     /note="O080_11"
                     /gene="werC"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01237.1"
                     /translation="MLTLAFSTIQDNLNDLLDYTCGLTLPDEVEIIIINQNFQIDNDH
                     KEKNMLHTAYENINIYTYYEKGISLSRNRAIERCKTKYIWFLDDDVRIIEEKLNKLVI
                     KLKSCIDCAYIVKIGSLEDSSLFYKNYKKRKIGIVNDKKELLRISSIEIICSMNVIIK
                     NNLTFDTTLGLGTFYPCCEENKFIIEYYKYAVVEFLELTPVLHTTKREHRLSIGEGHY
                     RSRGTIAKEFNFLVRIALVLRWSLRENNNVSFQKRITYLWQGIQAQKKTHIISPYESP
                     AEGRGTRNIVLAKLIGKNCIFLCTRFSHGRKKILPIEQFQKVEGLNIRFISTISYKTN
                     LSARRLIAHWFTATSTSIYLIVNTRKNDIVLVSSIPPEVILLVSIIQLIKKYQIVVDV
                     RDIWPEAFPLAGMKGRIFSVYCKSLYKITFLLQNKKFIYVAPCFRKWISEYVPKNKVL
                     DEYFGFLGFDENRWRSVQTKSIDWLDTEKIKLIYIGYLESQFDITDIIKYVRDSKKYE
                     LTIVGHGAKNEYYKDIASNSTSIHFKGLLPSDEVVNVMSDSHIGVLPITRTAQMPNKL
                     FDYVGGCIPILSIGASDSSEFVKENDIGWNSDWGTNNIAQVLDNLTRNDILSKYNNLY
                     KIASLYSKEHSYQNLVKFIMSDNK"
     gene            13979..15205
                     /gene="wzy"
     CDS             13979..15205
                     /gene="wzy"
                     /note="O080_12"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAQ01238.1"
                     /translation="MTSLRLKDSFFIFILLVITSKYMIFSILPIGNVINVLACMLSLF
                     LLFRRRFIVKIKSTTQKLGCIFFILSLLLFNISKFSNELTLFNAIIPTGLIMVFMVLI
                     PLAFDKFDLIDALKKYSVFNFWLLVLGLTLYFLNLLGFLGASSLVAAADHANQDGYVS
                     LLNLAYYPSWINIKVSSFIIHRFSGVFWEPGTLGLYLIFLITIEIILFEHEKLGSKIR
                     IFVFILSGVASLSLLFFVSVVVLYFFHLVSQKKDRKTLLAYSLLICILTFICVYYYDY
                     LYQAVLYRLDFDTQRGFVGNTRSGVVFEFWNQFSSGGLLSQLIGFGPYSKFEGDSTSI
                     MIKIYQRGILGFIFLFLSFVCFSLKSSKLFFMPAWILALIILSQFEGAIFLVMMMLFS
                     ILCKYKMADHNQTSLS"
     CDS             15216..15962
                     /note="O080_13"
                     /gene="werD"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="BAQ01239.1"
                     /translation="MFKKERILGFEIVNANVEEIVQFALVTKNITVINTINPHSYIVS
                     KSDSFFRQSLIDSDFLIPDGSGICLASKLINGRKLKKIAGYDVFFNAMKQLNMSDGKV
                     YFLGSSELVLEKIKCNMYNDFPNILIKTLSPPFKSTFSVNEINDFVEDINKFSPDAVF
                     VGLTAPKQEKLIHEIKKRINTKLISGVGAVFDFYAGTITRPSQLWIDLHLEWLIRFLG
                     EPKRLWRRNFISTPLFLIDVTKEKIIKNIK"
     gene            16115..17521
                     /gene="gnd"
     CDS             16115..17521
                     /gene="gnd"
                     /note="O080_14"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAQ01240.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKTEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            17770..18936
                     /gene="ugd"
     CDS             17770..18936
                     /gene="ugd"
                     /note="O080_15"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAQ01241.1"
                     /translation="MKITISGTGYVGLSNGILIAQNHEVVALDIVQAKVDMLNKKQSP
                     IVDKEIEEYLATKDLNFRATTDKYDAYKNADYVIIATPTDYDPKTNYFNTSSVEAVIR
                     DVTEINPNAVMVIKSTIPVGFTKSIKECLGIDNLIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD"
     gene            19026..20060
                     /gene="wzz"
     CDS             19026..20060
                     /gene="wzz"
                     /note="O080_16"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAQ01242.1"
                     /translation="MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLV
                     QLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYTNAMNVIYGS
                     AVPKVSDIQTSLIGRYSTAFSALAETLDNQEEAEKLTIEPTVKNQPLPLAVSYVGETP
                     EGAQKQLAKYIQQVDDQVNEELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQ
                     IQEALQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQT
                     RQNLLDIESLKVDDLDIHAYRYVMKPTLPVRRDSPKKAITLILAVLLGGMVGAGIVLG
                     RNALRNYNAK"
     gene            complement(20157..20768)
                     /gene="hisI"
     CDS             complement(20157..20768)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAQ01243.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPKALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ"
BASE COUNT     6198 a   4061 c   4613 g   6201 t
ORIGIN
        1 cgccagggat ttcataacca gataattggt gccaacatca ccaactgtaa atttagtgat
       61 ttacaggggg acgctattga atggaacgtg gcgattaacg acagtgatat tttgatctcc
      121 gaccatgtca tcgagcgcat caactgtacc aacggcaaaa tcaactgggg cattggcata
      181 ggccttgcgg gaagcactta cgataataat tacccggaag atcaggcagt gaaaaacttt
      241 gtcgtggcga atatcacggg atcggattgt cggcagttga tccatgttga aaatggcaaa
      301 cattttgtta tccgtaatat caaagcccgc aatatcacgc cggatttcag taagaaagca
      361 ggcattgata acgcgacagt tgctatttac ggttgtgaca atttcgtgat tgataatatt
      421 gaaatgatta atagcgccgg gatgttaatc ggctatgggg taattaaagg caaatatctc
      481 tcgataccgc aaaatttccg agtgaataat attcaactgg ataataccca ccttgcttat
      541 aaattgcgcg gtatccaaat ctccgccggg aatgccgtct cctttgtggc gctgactaac
      601 attgagatga agcgtgcgtc gcttgagcta tacaataaac cgcaacacct ttttatgcgt
      661 aatatcaatg tgatgcagga atcctcagtt ggacccgcat tgagcatgaa cttcgacatg
      721 cgcaaagacg ttcgcggcgt ctttatggcg aaaaaagaaa cactgctgtc tcttgcaaat
      781 gttcatgcgg tgaatgagaa aggacaaagc tccgtcgata tcgacagggt taatcaccat
      841 attgttaatg tggaaaagat taactttaga ttgccggaac ggagagagta gatttgcgac
      901 cattcctgga aaaatggagc catacttagg aacaatgcta ctgcaatcca caacgaagcg
      961 gcgtaacatc acaagtaatt cagtaatcaa ttcagggtaa ttgatgctgg cgaaaaaaat
     1021 cgaacaagct ataattcagc aaccatttta caggtggatg aaataatgac gaatttaaaa
     1081 gcagttattc ctgtagcggg tcttgggatg catatgttgc ctgccactaa ggcgattccc
     1141 aaagagatgc taccgatcgt cgacaagcca atgattcagt acattgttga cgagattgtg
     1201 gctgcaggga tcaaagaaat cctcctggta actcacgcgt ccaagaacgc ggtcgaaaac
     1261 cacttcgaca cctcttatga attagaatct ctccttgagc agcgcgtgaa gcgtcaactg
     1321 cttgcggaag tgcagtccat ctgtccaccg ggcgtgacca ttatgaacgt gcgtcagggc
     1381 gaacctttag gtttgggcca ctccatttta tgtgcacgac ctgccattgg tgacaatcca
     1441 tttgtcgtgg tgctgccaga cgttgtgatc gacgacgcca gcgccgaccc gctgcgctac
     1501 aaccttgctg ccatgattgc gcgcttcaat gaaacaggac gcagccaggt gctggcaaaa
     1561 cgtatgccgg gtgacctctc tgaatactct gtcatccaga ccaaagagcc gctggaccgc
     1621 gaaggtaaag tcagccgcat cgtcgaattt atcgaaaaac cggatcagcc gcagacactg
     1681 gactcagaca tcatggccgt tggtcgctat gtgctttctg ccgatatttg gccggaactt
     1741 gaacgcactc agcctggtgc atgggggcgt attcagctga ctgatgccat tgccgaactg
     1801 gcaaaaaaac agtccgttga tgccatgctg atgacaggtg acagctacga ctgcggtaaa
     1861 aaaatgggct atatgcaagc gttcgtgaag tatgggctgc gcaacctcaa agaaggggcg
     1921 aagttccgta aagggattga gaagctgcta agcgaataat gaaaatctga ccggatgtaa
     1981 cggttgataa gaaaattata acggcagtga agattcgtgg cgaaagtaat ttgttgcgaa
     2041 tattcctgcc gttattttat ataaacaatc agaataacaa cgagttagca ataggatttt
     2101 agtcaaagtt ttccaggatt ttccttgttt ccagagcgga ttggtaagac aattagcgtt
     2161 tgaatttttc ggggtaagcg cgagtgggta acgctcgtca catcgtaggc atgcatgcag
     2221 tgctctggta gctgtaaagc caggggcggt agcgtgtgtt tttatttctt attagcaggt
     2281 actgataatg atattagtga ctggtggcgc tggctatgtt ggatcgcata ctgttttagc
     2341 tttgctaaat caggggatta atgtgaccgt tattgacaat cttagtaact cgtcaattga
     2401 agctattcga cgtattgaaa aaataagcaa caaaaaagta aattttgtac acggcgatat
     2461 caataatcgt gctatcatcg atagagtttt tggtgatcat aaaataaaag ccgtaatgca
     2521 ctttgcagcg ctgaaatcgg taagtgagtc tgtcaaaaaa cccttaaatt attatcagaa
     2581 taatgtttct ggaacgataa cactattgga agctatgcaa aaagcaggtg taaataattt
     2641 tatttttagt tcatctgcaa cagtttatgg ttcttcttct gggccaaata tagagagtga
     2701 tgaaataggt aatactacaa atccttatgg aacttctaag tattttattg aaagaatcct
     2761 tgaagattat tgtaagtcta ataaatcatt ttcagcaata agcctccgct attttaaccc
     2821 aacaggtgcg cacaaatcag ctaagatcgg tgaagatcca aatggcattc ctaataatct
     2881 aataccatat atatcacacg tggcttctgg aaaactagat tatctgaatg tttatggaaa
     2941 tgactatgat acgattgatg gcacaggtat gcgtgattat atccatgttg ttgatttggc
     3001 tgacggacat ataaaagcct tggagtatat gctaactaat aaaatagggt atgatatatt
     3061 taatttaggc acaggcaaag catatagcgt attgcaagtt attcaggcat ttgaaaaaat
     3121 ttcaatgaaa aaaatatcat atagagtcgt ctctcgacga gatggtgatt tggcaaaatc
     3181 ttgggcaaat actgataagg caaataaaat acttaactgg aaagccaagt atgatcttga
     3241 ggaaatgtta caagacgttt ggaattggca atcaaaaaac ccgaatggat atcaacgcta
     3301 attaattttt tttgctttga attgctgggt catcattaag tcttaatact aatcatgacc
     3361 tctgttaaat taagttattc atttggagtt attgagcgtt tgttattgtt atcaatttac
     3421 cttaggtgtt atgcatcatg aatcagagat gtaatgtaga aatatatatt aagttgttta
     3481 tatgtattgg taaagcattt tcgaatgtta tctaatatgt aagcatatta aatcattgcg
     3541 tcatttggtt tgtaatctgt tctcctttaa aaccagaact caattataat attaccaaat
     3601 tttaactaaa aaacatgtat taggaattac tatgactaaa gtagcactta ttactggcat
     3661 aaccggacaa gatggctcat atctggcaga gtttctgctg gaaaaaggtt acgaggtgca
     3721 tggtattaaa cgtcgtgcat cgtcgttcaa taccgagcgt gtggatcaca tttatcagga
     3781 cccgcactct tgcaatccta aactccatct gcattatggt gatctgactg atacctccaa
     3841 cctgacgcgc attttgcgtg aagtgcagcc ggatgaagtg tacaacctgg gcgcaatgag
     3901 ccacgttgcg gtttcttttg agtcaccaga atataccgca gacgtcgatg cgatgggtac
     3961 gctgcgcctg ctggaggcga tccgcttcct cggtctggaa aagaaaaccc gtttctatca
     4021 ggcttccacc tctgaactgt acggtctggt gcaggaaatt ccgcagaaag aaaccacgcc
     4081 gttctacccg cgatctccgt atgcggtcgc caaactgtac gcctactgga tcaccgttaa
     4141 ctaccgcgaa tcctacggca tgtatgcctg taacggtatt ctcttcaacc atgaatcccc
     4201 gcgccgtggc gaaaccttcg ttacccgcaa aattacccgc gcaatcgcca acatcgccca
     4261 ggggctggag tcgtgcctgt acctcggcaa tatggattcc ctgcgtgact ggggccatgc
     4321 caaagactac gtaaaaatgc agtggatgat gctgcaacag gaacagccag aagatttcgt
     4381 tattgctacc ggcgttcagt actccgtacg tcagttcgtg gaaatggcgg cggcacagct
     4441 gggcatcaaa ctgcgctttg aaggcacggg tgttgaagag aagggcattg tggtttccgt
     4501 caccgggcat gacgcgccgg gcgttaaacc gggcgatgtg attatcgccg ttgacccgcg
     4561 ttacttccgt ccggcagaag ttgaaacgct gctcggcgac ccgaccaaag cgcacgaaaa
     4621 actgggctgg aaaccggaaa tcaccctcag agagatggtg tctgaaatgg tggctaatga
     4681 cctcgaagcg gcgaaaaaac actctcttct taaatctcat ggatttaatg ttagcttatc
     4741 ccaggaataa ctaatgtctt tacaacgaat ttttattgct ggtcatcgcg ggatggtcgg
     4801 ttccgctatc acccgtcagc tcgaacagcg cggtgatgtg gaactggtat tacgtacccg
     4861 cgacgagctg aacctgctgg acagccgcgc ggtgcatgat ttctttgcca gcgaaagcat
     4921 tgaccaggtc tatctggcgg cggcgaaagt gggcggcatt gttgccaaca acacgtatcc
     4981 ggcggatttc atctaccaga acatgatgat tgagagcaac atcattcacg ccgcgcatca
     5041 gaacgacgtg aacaaactgc tgtttcttgg atcgtcctgc atctacccga aactggcaaa
     5101 acagccgatg gcagaaagcg agttattgca gggcacgctg gagccgacca acgagcctta
     5161 cgccattgcc aaaatcgccg ggatcaaact gtgcgaatct tacaaccgcc agtatggacg
     5221 cgattaccgc tctgtcatgc cgaccaacct gtacgggccg catgacaact tccacccgag
     5281 taattcgcat gtgatcccag cattgctgcg tcgcttccac gaggcgacgg cacagaatgc
     5341 gccggacgtg gtggtgtggg gcagcggtac accgatgcgc gaatttctgc atgtcgatga
     5401 tatggcggcg gcgagcattc atgtcatgga gctggcgcac gaagtctggc tggaaaacac
     5461 ccagccgatg ctgtcgcaca ttaacgtcgg cacgggcgtt gactgcacta tccgcgagct
     5521 ggcgcaaacc atcgccaaag tggtgggtta caaaggtcgg gtggtttttg atgccagtaa
     5581 accggatggt acgccgcgca aactgctgga tgtgacgcgc ctgcatcagc ttggctggta
     5641 tcacgaaatc tcactggaag cggggcttgc cagcacttac cagtggttcc ttgagaatca
     5701 agaccgcttt cgggggtaat gatgttttta cgtcaggaag actttgccac ggtagtgcgc
     5761 tccaccccgc ttgtctctct cgactttatt gtcgagaaca gtcgcggcga gtttctgctt
     5821 ggcaaaagaa ccaaccgccc ggcgcagggt tactggtttg tgccgggagg gcgcgtgcag
     5881 aaagacgaaa cgctggaagc cgcatttgag cggctgacga tggcggaact ggggctgcgt
     5941 ctgccgataa cagcaggcca gttttacggt gtctggcagc acttttatga cgataacttc
     6001 tctggcacgg atttcaccac tcactatgtg gtgctcgctt ttcgcttcag agtcgctgaa
     6061 gaagagctgt tactgccgga tgagcagcat gacgattacc gctggctgac gccggacgcg
     6121 ctgctcgcca gtgacgatgt tcacgttaat agccgtgttt attttaataa tgacccacgt
     6181 gcagtcattg gcttaaataa aaaggaagtc aaaaatgtct gaagtacctt tgattgctgt
     6241 cgtaatggct ggtggtacgg gtagccgcct ttggcctctg tctagagaac actatcctaa
     6301 gcaatttttg caactatcag gtgagagctc tttattgcaa tcaactttat taagactgtc
     6361 aactctttcc tgcgaaactc cattagtaat aacaaatgag caacatcgct ttgtggttgc
     6421 agaacaatta cgtcaaattg atcaattaag agataatatt attcttgagc catgtggaag
     6481 aaatacagct cccgctatag ctctttcagc atttactgct ttgaaacgta atgaacaaca
     6541 ggatcctatt ctgttgattc tcgctgctga ccatattata agaaaagcgg atattttttg
     6601 tgaagctatt caaaaatcga aaactgtagc tgaacaggga tatattgtaa cctttgggat
     6661 tatacctgaa tatgcggaaa caggttatgg ttatatagaa aaaggagaac cttttaaaaa
     6721 ttcaccaaat attactgatg ataaattttt tcatgttcaa caatttgttg aaaaacctaa
     6781 ccattcgaag gcagaagaat atgtttccac aggagaatat ctctggaata gcggaatgtt
     6841 tatgtttaaa gcatcagttt atttacaaga attgaaaaaa cacaggcctg atatatacga
     6901 aatttgtgag tatacagctt cattatccta taacgatctt gatttcatac gattgcctaa
     6961 acatattttc caagattgtc cgtcggaatc aattgatttt gcagttatgg aaaaaacaaa
     7021 aaattgcata gttcgtccag tagacattgg gtggagtgat gtaggctctt ggcattcttt
     7081 gtgggagatt agtgataaaa cgcaggacgg agatgtctgt aaaggtgata ttctaactta
     7141 taacactaaa aacaattata tatattctga atcagcccta gtggctgctg taggtgtaga
     7201 agatatagtt attgttcaaa caaaagatgc tattctcgtg tccaaaaaaa ctgaggttca
     7261 ggatgtgaaa aaaatagtag aaatgcttaa gaaacatgaa cgctcagagt atatatcgca
     7321 tcgagaggag tttcggcctt ggggaaaatt tgatgcgata gatcaggggg aacgatataa
     7381 agtcaaaaag atagttgtga aacccggcga aggactgtcc ttacgaatgc accatcatcg
     7441 ttctgagcat tggattgttc tttccggtac agcaaaagta actttaaacg ataaaacagt
     7501 attgcttgct gcaaatgaat caatctacat tcctctagga gcaacgtata gtcttgaaaa
     7561 tccaggaata atccctctaa atcttattga agttagttca ggcgattatt tgggtgagga
     7621 tgatattgta cggcaaaaag aacgctacag aatagatgac taatatatga aaaaattaac
     7681 ctgctttaaa gcctatgata ttcgcgggaa attaggcgaa gaactgaatg aagatattgc
     7741 ctggcgtatt gggcgtgcct atggcgaatt tctcaaaccg aaaaccattg tgttaggcgg
     7801 tgatgtccgc ctcaccagcg aaaccttaaa actggcgctg gcgaaaggtt tacaggatgc
     7861 gggcgtcgat gtgctggata tcggtatgtc cggcaccgaa gagatctatt tcgccacgtt
     7921 ccatctcggc gtggatggcg gcattgaagt taccgccagc cataatccga tggattataa
     7981 cggcatgaag ctggtgcgag aaggggctcg cccgatcagc ggtgataccg gactgcgcga
     8041 cgtccagcgt ctggctgaag ccaacgactt tcctcccgtc gatgaaacca aacgcggtcg
     8101 ctatcagcaa atcaacctgc gtgacgctta cgttgatcac ctgttcggtt atatcaacgt
     8161 caaaaacctc acgccgctca agctggtgat caactccggg aatggcgcag cgggtccggt
     8221 ggtggacgcc atcgaagccc gctttaaagc cctcggcgca cctgtggaat taatcaaagt
     8281 gcacaacacg ccggacggca atttccccaa cggtattcct aacccgctac tgccagaatg
     8341 ccgcgacgac acccgcaatg cggtcatcaa acacggcgcg gatatgggca ttgcctttga
     8401 tggcgatttt gaccgctgct tcctgtttga cgaaaaaggg cagtttatcg agggctacta
     8461 cattgtcggc ctgctggcag aagcgttcct cgaaaaaaat cccggcgcga agatcatcca
     8521 cgatccacgt ctctcctgga ataccgttga tgtggtgact gccgcaggtg gcacgccggt
     8581 gatgtcgaaa accggacacg cctttattaa agaacgtatg cgcaaggaag acgccatcta
     8641 cggtggcgaa atgagcgccc accattactt ccgtgatttc gcttactgcg acagcggcat
     8701 gatcccgtgg ctgctggtcg ccgaactggt gtgtctgaaa ggaaaaacct tgggcggact
     8761 ggtgcgcgac cggatggcgg cgtttccggc aagcggtgag atcaaccgca aactggcgca
     8821 acccgttgag gcgattaacc gcgtggaaca gcattttagc cgtgaggcgc tggcggtgga
     8881 tcacaccgat ggcatcagca tgacctttgc cgactggcgc tttaacctgc gctcctccaa
     8941 caccgaaccg gtggtgcggt tgaatgtcga atcgaaagcg gctcctaaat taatggaaga
     9001 aaaaacggaa ctgcttttaa aaatattaat gagggactga tattttttaa ttattagaat
     9061 attgcatatg tcaaagttta taatcctttt tgcaagaggc tatgaagttc ttatagcatt
     9121 ttgtttatta aaactcatgt cggacttttt gtctccgctt gaatatgcgc aattaaatct
     9181 ttttgtggca ataactcaag gtattgcctt gttttttata tcacctcttc agaattggat
     9241 attagtaaat aatgataata tcgcatgtga gatagggtta aattcaacaa tattatttga
     9301 atttatatac tcatccgcaa tatcggttgt tgcgtgttta ttgttaatta tatcaggtac
     9361 acaccatgaa ttaataaatg ctggtatatt atatcttttt atcttggctg taataacacc
     9421 tgtgttatct caaacagtta taccgatcct taatttacaa ggaaaaataa tacaattcgc
     9481 agggttatcg attttgggtg ctactttggg aattataatt ccagtgtctt ttgtaagctt
     9541 atataaagat gattttgaag catggcttct agggggagta attgcacaac tattggttat
     9601 aataatcgga ttatttattg ggaatcatag tcaatcttta ggattatttt taggattaaa
     9661 aaaaatcccc tatagaaaaa tctttgtttt ttctctccct ctttgtgttg ccattggatt
     9721 ccagtggtac aatgcacaag gttttagatt gtctctgcag acagtagtag atttgaaaac
     9781 tttaggtgca tttattatgg gatttggctt tggtggaaaa tttctcaatg caattgagaa
     9841 agttttttct acagtgttac tccctcaact ctataataga aaaaaagatt ccagcataaa
     9901 gaaagagtgg ctcatatata tattcaaaat gtcggcaata tattccgtgg ctacctttgt
     9961 cattatattg ttatctcaaa aaatataccc aattataatt tccgaaaaat atgcagaggg
    10021 gcagaaatat attgttgcag gagtgatttt tgatatgttc cgttgtatgc aaaacgctgt
    10081 atatcagtat aatttaatag tttcaaagaa ccatattcag ttaatcatga acatgtgtat
    10141 aacgttattt gtttttgcat ttatatattt cataaacaaa taccaacttg aattctcata
    10201 ttttgtgatg atgcttcctg tggtgatggg ggcaattact ctaatttcgt ttattagaaa
    10261 ctacatggat gaatatgaaa atagttaata tttatggtgg attaggtaat gcattatttc
    10321 aagttgcttt cgctttatat ttaagtgata ttgggcacaa tgtgaaaatc gatactttag
    10381 gattaacagc cgaatttagg aacaagctta gatatttttt aaaagcatgt aatataaata
    10441 tcaacgagtg ctcatatgag gagagattaa gaagttctat tatactttct agacgacaag
    10501 taaagcataa agaattactt ttattgaaat ttctcttccc acaaaaaata tataaagaaa
    10561 taatatgggg agaacttcct tcatgtgagc ataactacta ttatggatat tttcaaaatt
    10621 atgagctggc tttaaaatat gcaaaaatat tttccaaggg tttaaataaa atagcaaatg
    10681 aaaataattt tgaacgtcca tttacacaag atgtctttgt tcatcttaga ggcggtgatt
    10741 atcaaacggc gcatgctgtt aaagtacatg gtctattaga tgaaaaatat tattcggagg
    10801 cattcaaatt ttttgaaagt cagcctaaac gagtctttac taatgataaa cgttatgcct
    10861 caaagatttt gggtaaaaat atttttgagt attctgaggg aatagatttt atatatccag
    10921 acatagctga tatgtattta atgtcaagat atgctaatgg tattattgcg aatagcacat
    10981 ttagtttttg gtctgcaatt ttaggtgata atggggataa aaaaatcata tgccctataa
    11041 aatggttcgc tgatgaaagg ttgcaaaaag aatcattcaa aatcaaacca ccccattgga
    11101 tcgaaagatg aagaaagttt cagtgttgat tgccagttat aattgtgctc aatttattgg
    11161 tgatactttg cattctttat gttctcagac tatgaataag gatgattatg aaataattat
    11221 cgttgacgat ggctcaacag acgatagtgt aaatataatt aactctttga ttaaagaaca
    11281 gaaaaatgtt atttttcgct cccgaactac taatctaggt gtaattaaaa caagaaacga
    11341 gttactcctg ctggcaaaag gacgtagtga atatatagca tggtgtgatt cagatgatat
    11401 ttataataaa gataaacttc tcagacaata tacatatatt aaaaagaaaa aactaattgg
    11461 ctgtggaact tggtacaaaa aatttggact tcatgataaa agaataatta aattcctgaa
    11521 ccctgaagct aacaggtttt ttttactttt cggtacacct gttggatttc cgacatttat
    11581 gcataaaaat aatcttgatg tgttttttga tgaaacgtta agttcatctg aagattatga
    11641 ttatttgtca aaaatatgcc aacttggtga tattgggaat atacctaaat tttacacata
    11701 ttatcgaact catctaaagc aggagtcatt gggtaatcat agcaggcaac gtattatgca
    11761 tgtgcatttg tcccaaaaaa tatacaatgc atattttgct gataaaattg atgagcaaaa
    11821 ctggattgac tttccatctg tactagatct tcgcgatgta aaacaaatta ttgaattgca
    11881 aaataaatat ttcacattgt ttggtgaggt tttttgcgct attgttgatt acaggtttat
    11941 tttgttgaat aaaaataaac caagatgttt gatgtattat tttattaaaa gaaactttaa
    12001 actattgtat atattcaagc tttttagggg gaaaaatgtt gacgttagcg ttttcaacaa
    12061 ttcaagataa tttaaatgat ttacttgatt atacttgtgg tcttacactt ccggacgaag
    12121 tggaaataat cattattaat caaaactttc aaatagataa tgatcataaa gaaaaaaata
    12181 tgttacacac ggcatatgag aatatcaata tatatacata ttatgaaaaa ggtattagcc
    12241 tcagtagaaa tcgagctata gaaagatgta aaacaaaata catatggttt ttagatgacg
    12301 atgttaggat cattgaagaa aaacttaata aattagttat caaactcaaa agttgtattg
    12361 attgtgctta cattgttaaa ataggtagtc ttgaagactc atcgttattc tataaaaact
    12421 ataaaaaacg caaaattgga atagtaaatg acaaaaaaga attattaaga attagttcaa
    12481 tcgaaataat atgtagcatg aatgtaatta tcaaaaataa cttaactttt gatacaacat
    12541 tggggttagg gacattttat ccttgctgtg aagaaaataa atttattatt gaatattata
    12601 aatatgcagt tgttgaattt ttggaactta caccggtact tcatactaca aaaagagagc
    12661 atagattatc tataggggaa gggcattatc gaagtcgagg aacaattgct aaagaattca
    12721 actttcttgt gcgcattgct ttagtattac gttggagtct tcgagaaaac aacaatgtta
    12781 gttttcaaaa gcgaattact tacttatggc aaggaataca ggcacaaaaa aagactcata
    12841 tcatctcacc ttatgagtcc cctgctgaag gtcgaggtac acgtaatatt gttttagcaa
    12901 aattaattgg taaaaattgt atttttttgt gtacccgatt tagtcatggg agaaaaaaaa
    12961 tcctccctat tgaacaattt caaaaggttg aagggcttaa tattcgattt atttcaacta
    13021 tttcatataa gactaatctt tctgcacgta gattaattgc tcactggttt accgcaacgt
    13081 caacgagcat ttatctaatt gtaaatactc gtaaaaatga tatagtgctt gtttcaagca
    13141 taccaccaga agtgatttta ttagtttcaa tcatccaatt gatcaaaaaa tatcaaattg
    13201 tagttgatgt tcgcgatatc tggcctgaag cttttccgtt ggctgggatg aaaggccgga
    13261 ttttttcagt ttattgcaaa tcattatata aaatcacctt tttgctccaa aataaaaaat
    13321 ttatttatgt agcgccttgt tttagaaaat ggatttcaga atatgtgcct aaaaataaag
    13381 tattggatga atattttgga tttttggggt ttgatgaaaa tagatggcgt tctgtacaaa
    13441 cgaaatcaat agattggctg gatacagaaa aaataaaact aatatatata ggatatttgg
    13501 aatctcaatt tgatataacc gatattataa aatacgtccg agatagtaag aaatacgaac
    13561 ttacgatagt cggtcatggg gccaaaaatg aatattacaa agatatcgcc tcgaattcta
    13621 cttctatcca ttttaaagga cttcttcctt ccgatgaagt tgttaatgtt atgtctgatt
    13681 cacatatagg tgttttgcct ataaccagaa ctgcgcaaat gcctaataaa ctatttgatt
    13741 atgtaggcgg ttgtatacct attttaagta tcggtgcatc agattcctca gagtttgtaa
    13801 aggaaaatga tattggatgg aatagtgact ggggaactaa taatatagct caggtattag
    13861 ataatttaac gcgtaatgat atactttcga aatataataa tttatataaa atagcctcct
    13921 tatattccaa ggagcattca tatcagaatt tggtaaagtt tattatgagt gataataaat
    13981 gacttcattg aggcttaagg atagtttttt tatatttatc ttgcttgtta ttactagcaa
    14041 gtatatgatt ttttcaatat tacccattgg caatgtaatt aatgttcttg catgcatgct
    14101 tagtttgttt ttacttttta gacgtcgttt tatagtaaaa ataaaatcca ccactcaaaa
    14161 attaggatgc atttttttta ttctttcttt gcttttattc aatatttcaa agttttcaaa
    14221 tgaactaaca ctatttaatg ctattattcc tactggttta ataatggtat ttatggtgtt
    14281 gattccacta gcgtttgata aatttgattt aatcgatgct ttaaaaaaat actccgtttt
    14341 taatttttgg ttattagttc tggggttaac gctttatttt ttgaacttat tgggtttttt
    14401 gggggcatca tccttggttg ctgctgccga tcacgccaat caggatggct atgtttcact
    14461 cttaaattta gcttattatc cttcatggat aaatataaaa gtttcatctt ttataattca
    14521 tcggttttca ggtgtttttt gggaaccagg tactctcggc ttatatctca ttttcttaat
    14581 tacaattgag attattcttt ttgaacatga aaaattaggc tcaaaaataa gaatttttgt
    14641 ttttatttta tctggtgtgg cttcgttatc attgcttttt tttgttagcg tagtagtttt
    14701 atattttttt catttggttt cacaaaagaa agatcgcaaa acattgcttg catattctct
    14761 tttgatttgt attctgacct tcatttgtgt ctattattac gattatctat atcaagccgt
    14821 attgtataga ttggactttg atactcaaag ggggtttgtt ggtaatactc gtagtggggt
    14881 agtatttgaa ttttggaatc agttttcatc tggaggttta ttgagccaac ttattggctt
    14941 tgggccatat tcgaagtttg aaggtgattc aacatctatt atgattaaaa tctatcaacg
    15001 tggaatcttg ggatttattt ttctttttct atctttcgtt tgtttttcat tgaaaagttc
    15061 aaagttgttt tttatgcctg cttggatctt ggctctcatt atattatccc agtttgaagg
    15121 agctattttt ttagttatga tgatgttatt ttcaatccta tgtaaatata aaatggcaga
    15181 tcataatcaa acttcattaa gttaggaaaa ccaaagtgtt caaaaaagag agaatcttag
    15241 ggtttgaaat tgtaaatgca aatgttgaag aaattgtaca gtttgcttta gtcactaaaa
    15301 atattacggt cattaatact atcaatcctc attcatatat tgttagtaag agtgattcat
    15361 tctttcgcca atcattaatt gattctgatt ttttaatccc tgatggttca ggaatatgtt
    15421 tagcatcaaa attaatcaat ggtcgtaagt taaaaaaaat tgcaggttat gatgtttttt
    15481 ttaatgcaat gaaacaattg aatatgtcgg atggaaaagt ctattttctt ggttcttcag
    15541 agttagttct ggagaaaata aaatgcaaca tgtataatga ttttcccaac atattaatta
    15601 aaacattatc accaccattt aaatcaacct tctcagtcaa tgaaataaat gattttgttg
    15661 aagatatcaa caaatttagt ccagatgccg tttttgtcgg attaaccgca cctaagcagg
    15721 aaaagttaat acatgaaata aaaaaaagaa tcaatacgaa attaatatca ggtgttggtg
    15781 cggtcttcga tttttatgcc ggtactataa cacgtccatc acaattatgg attgatttgc
    15841 atttagagtg gcttatacgg ttcttggggg aacctaaacg gctatggcgt aggaatttca
    15901 tatccacccc cttattttta atagacgtta ctaaagaaaa aatcattaaa aatattaaat
    15961 gaaactgcta ttatgaatta aatttataag tattttaaga tttggttata aatgattttt
    16021 atgaaatata aataataatc gtaaatcgtt tgttattttt cataatatct aaatctgtac
    16081 aaacccgtgg tgacccccct gacaggagta aacaatgtca aagcaacaga tcggcgtcgt
    16141 cggtatggca gtgatggggc gcaaccttgc gctcaacatc gaaagccgtg gttataccgt
    16201 ctctattttc aaccgttccc gtgaaaagac cgaagaagtg attgccgaaa atccaggcaa
    16261 gaaactggtt ccttactata cggtgaaaga gtttgttgaa tctctggaaa cgcctcgtcg
    16321 catcctgtta atggtgaaag caggtgcagg cacggatgct gctattgatt ctctcaagcc
    16381 atacctcgat aaaggcgaca tcatcattga tggtggtaat accttcttcc aggacaccat
    16441 tcgtcgtaac cgcgagcttt ctgccgaagg ctttaacttt atcggtaccg gtgtttccgg
    16501 cggtgaagaa ggcgcgctga aaggtccttc cattatgcct ggtgggcaga aagaagccta
    16561 tgagctggtt gcaccaatcc tgaccaaaat cgccgcagta gctgaagacg gtgagccatg
    16621 cgttacctat attggtgccg atggtgcagg tcactatgtg aagatggttc acaacggtat
    16681 tgaatacggc gatatgcagc tgattgctga agcctattct ctgcttaaag gtggcctgaa
    16741 tctttccaac gaagaactgg cgcagacgtt taccgagtgg aataacggtg aactaagcag
    16801 ctacctgatc gacatcacca aagatatctt caccaaaaaa gatgaagacg gtaactacct
    16861 ggttgatgtg attctggatg aagcagcaaa caaaggtacg ggcaaatgga ccagccagag
    16921 tgcgctggat ctcggcgaac cgctgtcgct gattaccgag tctgtgtttg cacgttatat
    16981 ctcttctctg aaagatcagc gtgttgccgc atctaaagtt ctctctggcc cgcaagcaca
    17041 gccagcaggc gacaagactg agttcatcga aaaagttcgt cgtgctctgt atctgggcaa
    17101 aatcgtttct tacgctcagg gcttctctca gctacgcgcc gcgtctgaag agtacaactg
    17161 ggatctgaac tacggcgaaa tcgcgaagat tttccgtgct ggctgcatca tccgtgccca
    17221 gttcctgcag aaaatcaccg atgcctatgc cgaaaatccg cagatcgcta acctgctgct
    17281 ggctccgtac ttcaaacaaa ttgccgatga ctaccagcag gcgctgcgcg atgtcgttgc
    17341 ttatgcggta cagaacggta tcccggttcc gaccttcgcc gctgcggttg cctattatga
    17401 tagctaccgt gctgctgttc tgcctgcgaa cctgatccag gcacagcgtg actatttcgg
    17461 tgcgcatact tataagcgca ttgataaaga aggtgtcttc cataccgaat ggctggatta
    17521 atctgattta aaccaattaa tcaatgcaag gcccggagaa accctccggg cttttttatt
    17581 atacaaagcg gcaggttatg gccttttttt ataatttata gttaaaaacg cgatataata
    17641 aagcgccgca cagcaggatc gctgccttga cagttcatct acatcagcgt taaaaatccc
    17701 gcagtagatg aagttgtggt ggtggattaa tgaccactct aaatgtttaa ccggaagaag
    17761 tcagagctaa tgaaaataac aatttcagga acaggttatg ttggtctttc aaatggtatt
    17821 ctgattgcgc aaaatcacga agtggttgca ctggatatcg ttcaggccaa agtggacatg
    17881 cttaacaaga agcagtcacc gattgttgat aaggagattg aagagtatct ggcgactaaa
    17941 gatctcaatt tccgcgctac gacagataag tatgacgcgt ataaaaatgc cgattacgtt
    18001 attattgcca cacctaccga ttatgatccg aaaacaaatt attttaatac ctcaagcgtg
    18061 gaagcggtca ttcgcgatgt gacagaaatt aatcctaatg ctgtcatggt gattaaatct
    18121 acaattccgg taggtttcac caaatcaatt aaagaatgtc tgggtatcga taaccttatt
    18181 ttctctccgg aatttctccg tgaaggtaaa gctctttacg ataatctcca tccgtcacgt
    18241 attgtcatcg gtgagcgttc agaacgcgca gaacgttttg cggcgttatt acaggaaggc
    18301 gcgattaagc aaaatatccc aaccctgttt accgattcaa ccgaagcaga agcgattaaa
    18361 cttttcgcta atacttatct ggcgatgcgc gtagcatact ttaatgaact ggatagctat
    18421 gcagaaagtt tagggctgaa tactcgccag attatcgaag gcgtttgtct cgatccgcgt
    18481 attggcaacc attacaacaa tccgtcgttt ggttatggtg gttattgtct gccgaaagat
    18541 accaagcagt tactggcgaa ctaccagtct gtgccgaata acctgatctc ggcaattgtc
    18601 gatgctaacc gcacacgtaa agactttatt gccgatgcca ttttgtcacg caaaccgcaa
    18661 gtggtgggta tttatcgtct gattatgaag agcgggtcag ataacttccg tgcgtcttcc
    18721 attcagggga ttatgaaacg tatcaaggcg aaaggcgttg aagtgatcat ctacgaaccg
    18781 gtgatgaaag aagattcatt cttcaactct cgcctggaac gtgatctcgc caccttcaaa
    18841 caacaagccg acgtcattat ctccaaccgt atggcagaag agcttaagga tgtggcagac
    18901 aaagtctaca cccgcgatct ctttggaagc gactaacatc ctgttatcag ggcgattttc
    18961 gccctgattc tcttatgttc cctttgtaat aattcattat ttttatcatt tatcctatag
    19021 cattcatggc gattatcgct aaactatggc gacttaaaat tatttcgtcc gttagggtaa
    19081 tgatgagagt agaaaataat aatgtttctg ggcaaaacca tgacccggaa cagattgatt
    19141 tgattgattt actggtgcag ttgtggcgtg gcaagatgac aattatcatc tctgtcattg
    19201 ttgctattgc cctggctata gggtatctgg ccgttgccaa agaaaagtgg acttccacag
    19261 ctatcgttac tcaacctgat gtggggcaaa tcgctggtta taccaacgcg atgaatgtga
    19321 tctacggatc ggctgtaccg aaagtctccg acattcagac ttcacttatc ggacgttaca
    19381 gcactgcatt ctcagcatta gcggaaacgc tggataacca ggaagaagca gagaagctga
    19441 ccattgagcc taccgttaaa aaccagccgt taccactggc ggtgtcttat gttggtgaaa
    19501 cacctgaagg tgcgcagaaa cagttggcga agtatatcca gcaagttgac gaccaggtta
    19561 atgaagaact ggaaaaagac ctgaaagaca acatcgcgct gcgtatgaaa aacttgcagg
    19621 attctctgaa aactcaggaa gtagtcgcgc aggagcagaa agatctgcgt atccgtcaga
    19681 ttcaggaagc gttgcagtat gcgaatcagg cgcaggtgac aaagccacag gttcagcaga
    19741 ctgaagatgt gacacaagat acgttgttcc ttttggggag cgaagcgctg gagtcgatga
    19801 ttaagcacga ggcgacccgt ccgttggtat tctcaccaaa ctactatcag acacgtcaaa
    19861 acctgctgga tatcgaaagc ttaaaagttg atgatcttga tattcatgct taccgctatg
    19921 taatgaaacc gacgttacct gttcgtcgcg atagcccgaa aaaggcaatt accttgattc
    19981 tggcggtgct gctgggcggc atggttggcg cggggattgt gctggggcgt aacgctctgc
    20041 gtaattacaa cgcgaagtaa tcttttcggt tttaaagaaa atgggcaggg tggtgacacc
    20101 ttgcccattt ttttggccgg atgcgacaac aatatcgcat ccgctcagcc cgcaacttac
    20161 tgatgccgtt tacgcaggtt ctcaatcacc gttgttaaat ccagatcctg atcctgcaac
    20221 aacaccagca ggtgatacat caaatcagat gcctcgttgg tcagctcaaa gcggtcatgt
    20281 accgttgctg ccagtgcggt ttccacgcct tcttcgccca ctttctgcgc aatgcgcttg
    20341 gtgccgctgg catacagttt ggcagtgtag gaggtttccg ggtcggcaga tttacgttcg
    20401 gcgagcagtt gttccagttg atagaggaac agccactggt gagcggtgtc gccgaagcag
    20461 ctgctggtgc ctttgtggca ggttggcccg atgggattcg ccagcaccag taacgtgtcg
    20521 ttgtcgcagt ccggcgcaat actcaccaca ttgaggaaat tgcccgacgt ttcgcctttg
    20581 gtccacagtc gctgtttagt gcgcgagaag aaggtgactt tgccgctttc gatggttttg
    20641 tccagagctt tcgggttcat atagcccagc attaacactt cgccagatac cgcgtgttgc
    20701 acaatcaccg gcataagtcc gtcggttttt tcccagtcca gttcgcgacg ttgttgttct
    20761 gttaacatat cctgatctcc acgccctgtg ttgccaggta cgcttttaat tcaccaatat
    20821 tgattatttg tttgtggaat acggaagctg ccagcgcgcc gtcaacgtcg gcatcgcgga
    20881 aggcttcgag gaagtgttcc atggtgcccg cgccaccgga agcaatcagc gggacgtggc
    20941 aaacttcacg cacttttttc agttgttcga ggtcgtaacc gttacgcacg ccgtcctgat
    21001 tcatcatgtt gaggacgatt tctccggcac cgcgtttttg cacttcctgt acccagtcga
    21061 gcgtttccca ctg
//
