LOCUS       DQ180602               14333 bp    DNA     linear   BCT 14-JUN-2007
DEFINITION  Escherichia coli serotype O98:K?:H8 O antigen gene cluster, partial
            sequence.
ACCESSION   DQ180602
VERSION     DQ180602.1  GI:126010586
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 14333)
  AUTHORS   Cunneen,M.M. and Reeves,P.R.
  TITLE     The Yersinia kristensenii O11 O-antigen gene cluster was acquired
            by lateral gene transfer and incorporated at a novel chromosomal
            locus
  JOURNAL   Mol. Biol. Evol. 24 (6), 1355-1365 (2007)
   PUBMED   17400574
REFERENCE   2  (bases 1 to 14333)
  AUTHORS   Cunneen,M.M. and Reeves,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-AUG-2005) School of Molecular and Microbial
            Biosciences, University of Sydney, Building G08 Maze Cresent,
            Sydney, NSW 2006, Australia
FEATURES             Location/Qualifiers
     source          1..14333
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /serotype="O98:K?:H8"
                     /db_xref="taxon:562"
     gene            <1..687
                     /gene="galF"
     CDS             <1..687
                     /gene="galF"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate uridylyltransferase"
                     /protein_id="ABB04482.1"
                     /db_xref="GI:126010587"
                     /translation="SYELESLLELRVKRQLLAEVQSICPPGVTIMNVRQSEPLGLGHS
                     ILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVLAKRMPGDL
                     SEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIWPELERTQ
                     PGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNLKEGAKF
                     RKGIEKLLSE"
     misc_feature    <1..>14333
                     /note="O antigen gene cluster"
     gene            1109..2389
                     /gene="gna"
     CDS             1109..2389
                     /gene="gna"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-N-acetyl-D-galactosamine
                     dehydrogenase"
                     /protein_id="ABB04483.1"
                     /db_xref="GI:77862416"
                     /translation="MSFNLENYKIGIIGLGYVGLPLAVEFGKKIKTLGFDINEKRIKE
                     LSAGNDFTLECSSDELAQAYYLQYSCDYKELATCNVFIVTVPTPIDEYKQPDLTPLVK
                     ASETLGKIIKKDDIIIYESTVYPGATEEVCIPVIEKISGLVFNIDFFAGYSPERINPG
                     DKEHRVTTIKKVTSGSTPEIAEIVDKLYGTIITAGTHKASSIRVAEAAKVIENTQRDL
                     NIALINELAMIFNKLGIDTEEVLKAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQA
                     IGYHPEVILAGRRINDGMSKYVASQFIKAMLKKKLQIEGANVLIMGLTFKENCPDLRN
                     TKVVDILAELKEYNVNVDIYDPWVDVEEAYYEYGVNVLNTLSDKKYDGVIFAVAHSQF
                     KNMSKEEVHGIIRNDGVIYDLKYIIDPNLVDIRL"
     gene            2405..3451
                     /gene="gne"
     CDS             2405..3451
                     /gene="gne"
                     /codon_start=1
                     /transl_table=11
                     /product="putative UDP-N-acetyl-glucosamine-4-epimerase"
                     /protein_id="ABB04484.1"
                     /db_xref="GI:126010588"
                     /translation="MCQRGCLVKYKKIEDALSSKSETWLITGVAGFIGSNLLEALLKL
                     NQKVVGLDNFATGHQANLDEVKESVSAEQWSAFTFVEGDICEPETCVEVVKGVDHVLH
                     QAALGSVPRSIKDPITTNNTNISGFINMLVAAKDANVRSFTYAASSSTYGDHPALPKI
                     EENIGNPLSPYAVTKYVNELYAQVFARTYGFKSIGLRYFNVFGKRQDPNGAYAAVIPK
                     WTAAMINDEPLYINGDGETSRDFCFIENVVQMNILAAQSDASARDQVYNVAVGDRTTL
                     NQLFNVLKNTLKNNNVIYEKKPVYKDFRAGDVRHSQANIDKAKRLLGYVPTHDILDGI
                     KESMPWYISTLDVK"
     gene            3441..4742
                     /gene="wzx"
     CDS             3441..4742
                     /gene="wzx"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="ABB04485.1"
                     /db_xref="GI:77862418"
                     /translation="MLNNNLLKNIVIYGGVTGASRMLPILLLPFYLSAMPIEDYGRIE
                     VLVALFNFVIILGSLQLETAIQRYMYKVEDKLNYTYTILIATFFFSILILFLTVIFSI
                     KISFSLFNSGIESTNIRIIALSCVFYNLSSIFMIYFRYSEQEKIFYIISLFQVFVTSV
                     VTYLLVVVEKLANFGYVVGIFSGWLIVFLLSMFTILWSKRKFIGEIKPDFSILKLSIN
                     FALPQIPARIGSFFIQFGNRFIVLSYFGSATVALFGVSVKFAAPFQLLYIAFTMAWNP
                     YLYKNETSDDLEFKINKILKLLLIFVLLSSVALHYGSHWIIDKYFQNNYKEVKSLIFI
                     AVLPSGLLIAKDILETGVRLSGKTKYISHAYFLSVTVTISLMLLSKNINNVFESTLIG
                     TITLLLATYYYSEKVYHFKYSRCVLYTLCGLLIIILGNMII"
     gene            4756..5910
                     /gene="wzy"
     CDS             4756..5910
                     /gene="wzy"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="ABB04486.1"
                     /db_xref="GI:77862419"
                     /translation="MNRLQANAVLAHLISYYMFIIFIVCCIIYYSLFIAVGIDSHEPI
                     RGFFYPANIIDHYIYLENYESLKNGNVNFVGINNIGIALVYYIYFNLLELMGFIIIPE
                     KFSLILNLFIFFLCFISFKRIVRKLNLDITVTWLFIFNCSFWYFAQLINKDVFTIFIF
                     FKLIEYALYNNKIGIFLIFLFSFFIRIQLPAIICVYLFFIYTKPTLKNLIIAYLAISI
                     FNGYISRYQSLIIDESTLSDGLSAFVYQMNINYGVGSLLFNPVRIAQSLYSVLISFDF
                     TYEYGIDVSKLKNIPQVMIFIILSPWIIRAYVRYNCFMKTKVKYVMAIVLAFFLVWLL
                     NPTINSRYVMLIIPFLTLIGLYSLKFGKYIKHENIDNKLSLSSKHNSTFL"
     gene            5852..7051
                     /gene="wbwU"
     CDS             5852..7051
                     /gene="wbwU"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ABB04487.1"
                     /db_xref="GI:77862420"
                     /translation="MKILIINFHYPPSTTAHSYRWSLLRDYFLQHNHSVDYICGGQPS
                     EYDEENSICRINFPYTIKKNYVDLTQDIPIKKNSIKSKFISLSKYIYRKFFWPDGLWH
                     WLPFALHEVYKRRKVKYDLIIGYSPTFSAIIASYFYKKINDQVKFIVDFGDPFSVSTE
                     MPVNNYWLYGKLNHWVENKIFNSADLVSFTNEATYNLYKSAHPDISNFLVIPHLVNID
                     DFYTISEPKPSEKYKIGYVGAFHKGVREPNLVIEKILSLQDLFASKCQFNFYGPLNGV
                     SLPESERLKYHGVVERHEALGLMKSFNIIINVENESCPMSPSKIYECMATGKPILNFL
                     SSTRLSSFNNYPLVLNIDEDTHSSQIEKFIIDNVNNKLPRKIVDEILTGKTLSSIGDQ
                     YLNLAGD"
     gene            7054..8178
                     /gene="wbwV"
     CDS             7054..8178
                     /gene="wbwV"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ABB04488.1"
                     /db_xref="GI:77862421"
                     /translation="MPRIFINALSAKVGGGKTYINNLLTNMPKQECEIYIACPDKLII
                     PDDKRIKYLETKFANHNIFFRMLWELFYLPFLLLILRSNILFVPGGMDFTIFTFGIPK
                     VTMFRNMLPFDSKALSALPSWSLKIKNIILRVLMSRTMKSADSVIFISNYARNKIKDI
                     IKTNSYQIIPHGISEHFTPNIVPDTLLSQGRTKYILYVSRFEPYKNHLNLLRAYASLP
                     DSLKKKYHLVLVGESMEPAYSECQQFVEENNLQGQVIFKGKVAYEDLPSVYKSAALFV
                     YPSSCENCPNILLEAIGCGLPVIASKTEPMPEFAKDSALYFDENDYNDIAHKMNYVLD
                     NPAELNEMRNKSIFLRENYTWEKTALKTWEYLDNIGGNNV"
     gene            8171..9208
                     /gene="fnlA"
     CDS             8171..9208
                     /gene="fnlA"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlA"
                     /protein_id="ABB04489.1"
                     /db_xref="GI:77862422"
                     /translation="MFKNKTLLITGGTGSFGNAVLQRFLNTEINEIRIFSRDEKKQDD
                     MRKHFKSDKLKFYIGDVRDYQSVSNAMRGVDYIYHAAALKQVPSCEFYPLEAVKTNVL
                     GTENVLEAAITHGVKRVVCLSTDKAVYPINAMGISKAMMEKVIVAKSRNLTHTNTTIC
                     CTRYGNVMASRGSVIPLFIRQVVNGEAITITDPNMTRFMMTLDDAVDLVLYAFEHGRN
                     GDIFVQKAPAATIDVLVKALLDIMNEPRHPINVIGTRHGEKQYEALCSREEMFVAQEE
                     GNYYRVPADNRDLNYSKYYEHGDKNLSLVEDYNSHNTQQLDIEGMKTLLRKLDFIREI
                     ENGHLFIPEGV"
     gene            9205..10092
                     /gene="qnlA"
     CDS             9205..10092
                     /gene="qnlA"
                     /codon_start=1
                     /transl_table=11
                     /product="QnlA"
                     /protein_id="ABB04490.1"
                     /db_xref="GI:77862423"
                     /translation="MILNVMILGVTGMLGYSLFTNLKDYKNLNVIGTARNLLGKEQYF
                     KTQKQNLVLNIDATDIDSIDNVINSVDPDVVINCIGLIKQHEISKQHVEAIKINALLP
                     HQLAEVCNKYNAKLIQFSTDCVFDGKKGLYRESDTPNSTDLYGKSKCLGEVNYGKHLT
                     LRTSIIGHELNSSVSLIDWFLSQSTEVNGYSKAIFSGLPTCYIAKLLAEKIIANDSLK
                     GIYHLSANPIDKYTLISLVSEIYGKSIKINKSEKLIIDRSLDSTRLREAIGFIPPSWY
                     DLIKFMFNDYVTRYSLCKN"
     gene            10080..11213
                     /gene="qnlB"
     CDS             10080..11213
                     /gene="qnlB"
                     /codon_start=1
                     /transl_table=11
                     /product="QnlB"
                     /protein_id="ABB04491.1"
                     /db_xref="GI:126010589"
                     /translation="MQKLKVMTIVGTRPEIIRLSRIIAKLDAYCEHTLVHTGQNYDYE
                     LNQIFFDDLGIRTPDVFLECAGSSAAETMAQVISKSEDVFVKFQPDALLILGDTNSAL
                     AAITAKRNKIPIFHMEAGNRCFDLRVPEEINRKIVDHIADVNMPYSDIAREYLIREGL
                     RPDLIIKTGSPMDEVLTYYHDKIRASVIVQHLSLTANEYFLVSVHREENVDSDKNIHS
                     YVQVLNELAEKYKYPIIVSTHPRTRKKIEALNLQFHPLVNLLKPLGFSDYVRLQMDAK
                     VVLSDSGTITEESSILNFPALNIREAQERPEGFEEGVAMFTGMSIDRILQAINILESQ
                     PRGTTRLISKVSDYVAPNVSDKVLRIILSYTDYVNRVIWRKSL"
     gene            11195..12445
                     /gene="wbwW"
     CDS             11195..12445
                     /gene="wbwW"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ABB04492.1"
                     /db_xref="GI:77862425"
                     /translation="MEKIALKLVLIIDDYLPDSTRVGAKMFHELALELQSRGHVITVI
                     TPNRQQNIPLLIEKYDGITIWRFRSGPIKDVGRIQRAMNETFLSLKAWKAVQSLISPS
                     TFDGVIYYSPTIFWGGLVRKIKKRCNCPSYLVLRDLFPRWVVDAGIIKEGSFIERYFR
                     FFEKYSYQQANCIGLMSERNLEVFQSSNVGYHCEILRNWASLTPVMKNEEILASGFKA
                     RLSLQGKIIFFYGGNIGHAQDMANLMRLARNMRSFEQAHFLFVGQGDEVVLINSLARD
                     WELTNFTYLASINQNDFKTLLSEIDVGLFSLSASHSSHNFPGKLLGYMVQSVPILGSV
                     NAGNDLADLVNNSGAGFIHINGEDDKLLHSAKRLLLEPELRNKLGDAANTLLHEQFSV
                     TAAAKSIEQRLEADYACHHLYRVA"
     gene            12414..12818
                     /gene="wbuC"
     CDS             12414..12818
                     /gene="wbuC"
                     /codon_start=1
                     /transl_table=11
                     /product="WbuC"
                     /protein_id="ABB04493.1"
                     /db_xref="GI:77862426"
                     /translation="MRVITCTELHELYDNARKSERLRAHLLLHSCHDDKVQRLFIGMV
                     KGSYVEPHFHELPHQWEMFIVMEGQIKVCLYNQSGAIVRAFVAGDDADSSVVEFAPGD
                     IHSVECISEQALMMEVKEGPFDSNYAKVFPNW"
     gene            12997..>14333
                     /gene="gnd"
     CDS             12997..>14333
                     /gene="gnd"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="ABB04494.1"
                     /db_xref="GI:77862427"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAHT
                     FTDWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKEQRVAASKVLSGPKAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYHWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANIIQAQR"
BASE COUNT     4423 a   2413 c   2909 g   4588 t
ORIGIN
        1 tcttatgaat tagaatctct tcttgaactg cgcgtgaagc gtcagctgct ggcggaagtg
       61 cagtccatct gtccgccggg cgtgaccatt atgaacgtgc gtcagagcga acctttaggt
      121 ttaggtcact ccattttgtg tgcgcggcct gccattggtg acaatccatt tgtcgtggtg
      181 ctgccagacg ttgtgatcga cgacgccagc gccgacccgc tgcgctacaa ccttgctgcc
      241 atgattgcac gattcaacga aacgggtcgt agccaggtgc tggcaaaacg tatgccgggt
      301 gacctctctg aatactcggt catccagacc aaagaaccac tggaccgtga aggtaaagtc
      361 agccgcattg ttgaatttat cgaaaaaccg gatcagccgc agacgttgga ctcagacatc
      421 atggccgttg gtcgctatgt gctttctgcc gatatttggc cggaacttga acgcactcag
      481 cctggtgcat gggggcgtat tcagctgact gatgccatcg ctgaactggc gaaaaaacag
      541 tccgttgatg ccatgctgat gacaggtgac agctacgact gcggtaaaaa aatgggctat
      601 atgcaggcgt tcgtgaagta tgggctgcgc aacctgaaag aaggggcgaa gttccgtaaa
      661 ggtattgaga aattgcttag cgagtaagtt taaaaaatag acgccctgat agggcgtaat
      721 aacaaataac ggtagtcagc attcgacgcg gtgatgcaga tatgcccggg atgctgatac
      781 cgttttttca ttataaaaaa ctcatcattt cattgagtta actacaaaat ttagcactgt
      841 tttttataat gtttcttctt gtttctggca tcaattggta agataattag tgtttgagtt
      901 tagaggcttt gcggcagaga agcggagctt aacacgtctg tgagagtacg cagtgcactg
      961 gtagctgtaa agccagtggc ggtagcgtgt ttaaataaat acattagtac tactgcatat
     1021 tacatcattg taggctattt aagcgctaca tgttaagcga cagcgctagc tatcaaatct
     1081 tttaaagtta cttctcagga atagtaaaat gagctttaat cttgaaaatt ataaaatagg
     1141 aattattggg ctgggttacg ttggcttacc tttagctgtt gaatttggca aaaaaataaa
     1201 gactcttggt tttgatatca acgagaaacg gataaaagaa ttatcagcag gtaatgactt
     1261 tacgcttgaa tgtagttctg atgaactggc tcaagcttac tatcttcaat attcatgtga
     1321 ttataaagaa ttagcgactt gcaatgtatt cattgtgacg gtacctactc caattgatga
     1381 atataaacaa cctgatttaa cacctcttgt taaagcctcg gaaacactcg gaaaaataat
     1441 caaaaaagat gatattatta tctacgaatc aactgtttat ccaggtgcaa cagaagaagt
     1501 atgtatccca gtaattgaga agatctcagg tctggtattt aatatagatt tttttgccgg
     1561 ttacagcccg gaacgcatta atccgggtga caaagagcac cgcgtgacaa cgatcaaaaa
     1621 agtaacttct ggttcaacgc ctgaaattgc tgagattgtc gataaattat atggaaccat
     1681 catcaccgct ggaacgcata aagcatcttc gatacgtgtg gcggaagcgg ctaaagtgat
     1741 tgagaacacc cagcgtgatt tgaatattgc tctgattaac gaacttgcaa tgattttcaa
     1801 taagctgggg attgatacgg aggaagtatt aaaagccgca ggcactaaat ggaacttctt
     1861 accattcaga ccaggcttag ttggggggca ttgcatcgga gttgatccct actatttgac
     1921 tcataaagcg caagcgatag gttatcatcc agaagtcatc ctggcggggc gtagaattaa
     1981 tgatggaatg agtaaatatg tagcatcaca gttcattaaa gccatgctca agaaaaaatt
     2041 acaaattgaa ggtgctaatg tcttaattat ggggcttacc tttaaagaaa actgtccgga
     2101 tcttcgtaat acaaaagttg tagatatctt ggctgaactg aaagaataca acgtgaacgt
     2161 ggatatttat gatccatggg ttgatgttga agaagcctat tatgagtatg gggttaatgt
     2221 attaaacaca ttatctgata agaaatatga tggtgtgatc tttgcagttg ctcactctca
     2281 atttaaaaat atgagtaaag aagaagtcca tggaataatt agaaatgatg gtgttattta
     2341 tgatttgaaa tacatcattg accctaactt agtagatatt cgtctttaat caatacttga
     2401 tgcaatgtgt cagagaggat gcctagtgaa atataaaaaa atagaagacg ctttgtcttc
     2461 taaatctgaa acatggttga ttacaggtgt tgcgggattt atcggttcta acctattaga
     2521 ggccttacta aaacttaatc aaaaagtagt tggcttagat aattttgcaa ctggacatca
     2581 agcaaacctt gatgaggtta aagagtccgt ttcagctgaa caatggtctg cttttacctt
     2641 tgtggaagga gacatatgtg agccagagac gtgtgtggag gttgttaaag gagttgatca
     2701 tgtcctacat caggctgcat taggttctgt gcctcgttca attaaagatc caattactac
     2761 aaataataca aatatatcgg gtttcattaa tatgttggtt gccgccaaag atgccaatgt
     2821 cagaagtttc acttacgctg caagtagctc aacgtatggt gatcatcctg cattacctaa
     2881 aattgaagaa aatataggta atccgctatc tccatacgca gtgacaaagt atgtaaatga
     2941 attatatgcg caagtatttg caagaaccta cggattcaaa tcaattggat taagatactt
     3001 taatgtattt ggaaaacgcc aggatcctaa tggggcatat gctgctgtga taccgaagtg
     3061 gactgctgca atgatcaatg atgaaccgct gtatatcaat ggtgatggcg aaacaagtag
     3121 agacttttgt tttattgaga atgtcgtgca aatgaatatt cttgctgcac agtctgatgc
     3181 gtctgcaaga gatcaggttt ataacgttgc agttggtgac cgtacgacgc tcaatcaact
     3241 gtttaatgta cttaaaaata cattaaaaaa taataatgtt atttatgaaa aaaaaccagt
     3301 ctataaggac tttagggctg gggatgttcg tcattctcaa gcaaacatag ataaagcaaa
     3361 gcgcttatta gggtatgtgc caacacatga tatattggat ggtattaagg aatctatgcc
     3421 ttggtatata agcacattag atgttaaata ataatctctt aaaaaatatt gttatttatg
     3481 gtggagttac aggtgcatcg aggatgcttc ctatattact gttgccattt tatctttctg
     3541 caatgcccat agaggattat gggcgtattg aggttcttgt tgcactattt aattttgtaa
     3601 ttatactcgg ttcattacaa cttgaaactg cgattcaacg gtacatgtac aaagttgaag
     3661 ataaattaaa ctatacatac accatactaa tcgcaacatt tttcttttct atccttatac
     3721 tgtttctaac agtaattttt tcaataaaaa tatcattttc attgtttaac tccggcattg
     3781 agtctacaaa cataagaatc atagcattaa gttgtgtttt ttataatttg tcctcgattt
     3841 ttatgatcta ttttagatat tctgaacagg aaaaaatatt ttatatcatt tcactgtttc
     3901 aagtatttgt aacatcagtt gttacttatc tgcttgtagt tgttgagaag ttggcaaact
     3961 ttggatatgt tgtaggaata ttttcaggct ggctaatagt gtttttacta agtatgttca
     4021 ctattttatg gagcaagaga aaatttattg gggaaatcaa accagatttt tccatattaa
     4081 agttatcaat aaatttcgca ttacctcaaa ttccagctag aattggtagt ttctttattc
     4141 aatttggaaa cagatttatt gttttatcat attttgggtc tgcaactgtt gcattgtttg
     4201 gggtgtcagt caaatttgct gctccatttc agttgttgta tatcgcgttt acaatggctt
     4261 ggaatcctta tttatacaaa aatgaaacca gtgatgattt ggaattcaag attaataaga
     4321 ttctgaaatt gttattgata tttgttttgc ttagctccgt agcgcttcat tatggtagtc
     4381 attggataat agataagtat tttcaaaata attataagga agtgaaatca ttaatattta
     4441 tagccgttct accatcagga ctattaattg cgaaagatat attggaaact ggtgtgagat
     4501 tatctgggaa aacgaaatat atatcgcatg catatttttt atctgtgaca gtgactattt
     4561 cattgatgct tctctctaaa aatataaaca atgtttttga gtcgacgcta atcggaacaa
     4621 taacattatt gcttgcaaca tattattatt ctgaaaaggt ctaccatttt aagtattcca
     4681 gatgtgtttt atatacgtta tgtgggttac taataataat acttggtaat atgataattt
     4741 aatataggga atagtatgaa tagactccag gcaaatgcag tgcttgcaca tttaatatca
     4801 tattatatgt tcattatttt tattgtatgc tgcattattt attattccct ttttatagct
     4861 gtcggcattg atagccatga accaatacgc ggtttttttt atcctgcgaa cataattgat
     4921 cattatattt accttgagaa ttatgaaagt ttaaaaaatg gaaatgtaaa ttttgtaggc
     4981 ataaataata ttggtatcgc attagtttat tatatttatt ttaacttact agagttaatg
     5041 ggatttatta ttattccaga aaaattttcg ttaattctta acctgtttat ctttttttta
     5101 tgttttatta gtttcaagag aattgtacga aagctcaatc ttgatattac tgttacatgg
     5161 ttatttattt tcaattgtag tttttggtac tttgcacagt tgataaataa agatgttttc
     5221 acaatattta tattctttaa gttgatagag tatgctttat ataataataa gattggcatt
     5281 tttcttattt tcttattttc cttttttata agaattcagt tgcctgccat aatatgtgtt
     5341 tatttgttct ttatttatac taaaccaact ttaaaaaatt taatcattgc atatttggca
     5401 atttcaatct tcaacggata cataagtaga tatcaaagtc taattataga tgaaagtact
     5461 ttgagtgatg gactaagtgc ttttgtatat caaatgaata ttaattatgg tgtaggatct
     5521 ttattattta atccagttag gatagcgcaa tctctatata gtgtattgat ctcatttgat
     5581 tttacttatg aatatggaat tgatgtttca aagttgaaaa acattccaca agtcatgatt
     5641 tttattattt tatctccatg gataattaga gcctatgtaa ggtataattg cttcatgaaa
     5701 acaaaagtaa aatatgttat ggcaattgta ctagctttct tcttagtttg gttgctgaat
     5761 ccaacgataa attctagata tgttatgttg ataataccat ttcttacttt aattgggtta
     5821 tattctttaa aatttggtaa atatataaaa catgaaaata ttgataataa actttcacta
     5881 tcctccaagc acaacagcac attcttatag atggtcatta ttacgggact attttttaca
     5941 gcataaccat agtgtggatt atatctgtgg cggtcaacct tctgaatatg atgaagagaa
     6001 cagcatatgt aggataaatt tcccatatac catcaagaaa aattacgtcg atctcactca
     6061 agatattcca ataaaaaaga attcgatcaa gtcaaaattc atatcacttt ctaaatacat
     6121 atacagaaag tttttttggc ctgatggact gtggcattgg ctcccgtttg ctttgcatga
     6181 ggtttacaaa aggagaaaag taaaatatga ccttattatt ggatatagtc ccactttctc
     6241 agcgattata gcatcctatt tctataaaaa gatcaatgat caagttaaat ttattgttga
     6301 ctttggcgat ccattctctg tatctacaga gatgccagta aataattatt ggctatatgg
     6361 aaagcttaat cattgggttg aaaataaaat ttttaattct gctgatttgg tttcctttac
     6421 aaatgaggca acttataatt tatataagag cgcacatcca gatattagca attttttggt
     6481 aatacctcat ttagttaata tcgatgattt ttatactatt tctgaaccta aacctagtga
     6541 aaaatataag attggatatg ttggggcctt ccataaaggt gtcagagaac ctaatctagt
     6601 aatagaaaag attctcagtt tacaagacct atttgcttcg aaatgccaat ttaattttta
     6661 cggtccgctg aatggagtta gccttcctga atcagaaaga ttaaaatatc atggagtagt
     6721 tgagcggcat gaagcattag gcttaatgaa gtcatttaac ataataatca acgttgaaaa
     6781 tgaatcatgc cctatgtcgc caagtaaaat atatgaatgt atggcaacag gtaaacctat
     6841 attaaatttc cttagctcaa caagactgtc aagttttaat aattatcctc ttgtacttaa
     6901 tatagatgaa gatactcact cctcgcagat tgagaaattt atcattgaca atgtaaataa
     6961 taaattacca agaaaaattg ttgacgaaat attaacagga aaaacacttt cctctattgg
     7021 tgatcagtat ttaaatttgg ctggagatta acgatgcccc gaatttttat taatgcgtta
     7081 tctgctaagg taggaggagg taaaacctat atcaataatt tactaactaa tatgcctaag
     7141 caagaatgcg aaatttatat tgcctgtccc gataaattaa taattccaga tgataaaaga
     7201 attaaatatc tggaaacgaa atttgctaat cacaatatat tctttaggat gctgtgggag
     7261 ttgttctatc ttccattctt actgctgatt cttcgtagca atatattatt tgttccaggt
     7321 ggtatggatt ttaccatttt cacttttggg atacccaaag taacaatgtt tagaaacatg
     7381 ctaccttttg attcgaaggc tctaagcgca ctacctagtt ggagtctgaa gataaaaaat
     7441 ataatattaa gagtcttgat gtctcgtacc atgaagtctg ctgatagcgt catttttatt
     7501 tctaattatg ctagaaataa aattaaagac ataatcaaaa caaactccta tcagatcata
     7561 cctcatggaa tatctgaaca ttttactcct aacattgtac ctgatacatt attaagccaa
     7621 ggtaggacaa aatacatcct ttatgtatct cgctttgaac catataagaa tcatttgaat
     7681 ctattaaggg catatgcatc cttgcctgat tctctgaaaa aaaaatatca tctggttctt
     7741 gttggtgaat caatggaacc cgcttattct gaatgccaac aatttgttga agaaaataac
     7801 cttcaaggtc aggttatttt taaagggaaa gtagcatatg aggatcttcc gtctgtgtat
     7861 aaatctgctg cattatttgt ctacccttcc tcttgtgaga attgtcctaa tatactccta
     7921 gaagctattg gatgcgggct tccagtaata gcatctaaaa ctgaaccaat gcctgaattt
     7981 gcgaaagatt cggcattata tttcgatgaa aatgattata atgatattgc acataaaatg
     8041 aattatgttt tagataatcc agcagagctg aatgaaatga gaaataaatc tatcttctta
     8101 agagaaaact atacgtggga aaaaacagca cttaaaactt gggaatatct tgataatatt
     8161 ggaggcaata atgtttaaaa ataagacact tttaataaca ggtggtactg gctcattcgg
     8221 taatgctgtt cttcaacggt ttttaaatac agaaataaat gagataagaa ttttttcacg
     8281 tgatgaaaaa aaacaagatg acatgcgtaa acatttcaaa tcagataaat tgaaatttta
     8341 tattggtgat gtacgcgatt atcagagtgt ttcaaatgct atgcgcggcg ttgactatat
     8401 ataccatgcc gccgctttaa aacaagtacc ttcgtgcgag ttctatcctt tagaagcggt
     8461 taaaacaaat gtattaggca ccgaaaatgt tttagaagca gccattactc atggagtaaa
     8521 aagagtagta tgtctaagta cagataaagc agtttaccca atcaatgcca tggggatttc
     8581 taaagcaatg atggaaaaag tcatcgttgc caaaagccgc aatttaactc atacgaacac
     8641 aactatctgt tgtactcgtt atggtaatgt catggcctcc aggggatctg tgattccact
     8701 gtttataaga caggttgtta atggtgaggc tattactatt acagacccta atatgacccg
     8761 tttcatgatg acattagatg atgcagttga tcttgtctta tatgcctttg aacatggacg
     8821 taatggagat atatttgtac agaaagcacc tgctgccact atagatgtat tggttaaagc
     8881 attgttagat attatgaatg aaccaagaca ccctattaat gttattggca ctcgtcatgg
     8941 tgaaaagcaa tatgaagcac tatgtagccg tgaagagatg tttgttgcgc aagaggaagg
     9001 gaattattat cgagtgccag cagataaccg tgacctcaat tattcaaagt attatgaaca
     9061 tggtgataag aatctcagtc tagtggagga ttataattct cataatactc aacagttaga
     9121 cattgaaggt atgaagacac ttctgcgcaa acttgatttc atccgtgaaa ttgaaaatgg
     9181 tcatctgttt attcctgaag gagtatgatt ttgaatgtca tgattttagg tgtcactggg
     9241 atgcttggct atagtctttt taccaattta aaagactata aaaacctgaa tgtaattggc
     9301 acagcgcgta atcttcttgg gaaagagcaa tattttaaga cacaaaaaca gaatcttgtt
     9361 cttaatatcg atgctactga tattgatagc attgataacg tgattaattc ggttgaccct
     9421 gatgttgtta taaattgcat tggcctaatt aagcagcatg agatctctaa gcaacatgtt
     9481 gaggctatta aaattaatgc cttattacct catcaattag ctgaagtatg caataaatat
     9541 aatgccaagc taattcaatt ctcaacggat tgtgtttttg atggaaaaaa ggggctatac
     9601 cgtgaatctg atacgcctaa ttcaacggat ctatatggta aatcaaaatg tcttggtgaa
     9661 gtcaattacg gtaaacattt aactcttagg acatctatta taggtcatga gcttaattct
     9721 tcagtaagct taatcgactg gttcttgagt caatctactg aagttaatgg ttattcaaaa
     9781 gcgatatttt ctggtctgcc gacttgttat attgctaaat tattggctga aaagattata
     9841 gccaatgata gcttgaaagg aatatatcat ctttcagcca atccaataga taaatacaca
     9901 ttaatctcat tggtttcaga gatatatggt aagtctatta aaataaataa atccgagaag
     9961 ttgataattg atcgctcgct tgattcaact agactgaggg aggcaatagg atttattcct
    10021 ccatcgtggt atgacttgat taagtttatg tttaatgact atgttacaag gtattctcta
    10081 tgcaaaaatt gaaagtgatg actattgttg gcactcgacc tgaaattatc aggctatctc
    10141 gtatcattgc aaagcttgat gcttattgtg aacatacttt ggtacatact ggtcaaaact
    10201 atgattatga gcttaatcag attttttttg atgatctagg tattcgtaca cctgatgttt
    10261 ttttagaatg tgctgggagc agtgctgctg aaactatggc acaagtcatc agtaagtcag
    10321 aagatgtatt tgtaaaattc cagcctgatg cattattaat tcttggtgat acgaatagtg
    10381 cattagctgc tataactgcc aaacgtaata aaattcctat ttttcatatg gaagctggta
    10441 accgctgttt tgacttgcgt gtgccagagg aaattaatag gaaaattgtt gatcatattg
    10501 cagatgttaa tatgccttac agcgacattg cacgagagta tctgatcaga gaagggctta
    10561 gaccagattt gataattaaa acgggaagtc cgatggatga agtgttaact tattatcacg
    10621 ataaaattcg agcttctgtc attgttcaac atttatcctt aacagcaaac gagtattttt
    10681 tggttagtgt tcatcgtgaa gaaaatgttg attctgataa aaacatccat agttatgtac
    10741 aagtgttaaa tgaattagct gaaaaatata agtatccaat tattgtttct actcacccaa
    10801 gaacaagaaa gaaaatcgag gcgctaaact tacaatttca tcctctagtg aatcttctaa
    10861 aaccactagg atttagtgat tatgttcgtt tgcagatgga tgcaaaagtt gtattaagtg
    10921 atagcggaac cattactgag gaatcttcta ttttgaattt ccctgctcta aatattaggg
    10981 aagctcagga acgacctgaa ggttttgaag agggggtggc gatgtttacg ggaatgagca
    11041 ttgatagaat tttgcaagca attaatattc ttgaaagtca acctcgtgga actacgaggt
    11101 taataagtaa agttagcgat tatgtagcac ctaatgtttc agataaagtt cttcggataa
    11161 ttctgagtta tactgattat gttaatcgtg ttatatggag aaaatcgctt tgaaattggt
    11221 gctaatcatt gatgattatt tgcccgatag tactcgagta ggcgcaaaaa tgtttcatga
    11281 gttggctctc gaactacagt cccgcggaca tgtcatcacg gttattactc ccaatcgtca
    11341 gcaaaacatt cctttactaa tagaaaaata tgatgggata actatctgga gattcaggag
    11401 cggtccgata aaagatgttg gtcgtatcca gcgggcaatg aatgaaacat tcttgtcatt
    11461 gaaggcatgg aaggcagttc agagtttaat atctccgtct acttttgatg gagtaattta
    11521 ttactcccca actattttct ggggtggtct ggttagaaaa atcaagaaac gctgcaactg
    11581 cccatcatat cttgtactcc gggatttgtt ccccagatgg gtggttgatg ctgggattat
    11641 aaaagaaggt tcttttatag agaggtattt caggtttttt gagaaatatt cttatcagca
    11701 ggctaattgt attggtctta tgtccgagag aaatcttgag gtctttcagt ctagtaatgt
    11761 gggatatcac tgtgaaatcc tgaggaactg ggccagtttg acgcctgtaa tgaaaaacga
    11821 agaaattctt gcttcgggat ttaaggcgcg cttatccctt cagggaaaaa ttattttttt
    11881 ctatggaggg aatattggac acgctcaaga tatggcaaat ttaatgcgtc ttgctcgcaa
    11941 tatgcgctct ttcgagcaag ctcatttcct ttttgtcggg caaggtgatg aggtagtgct
    12001 gataaattct ctagcaagag attgggaatt aacaaatttt acttatttag cgtctattaa
    12061 tcagaatgac tttaaaaccc tcctttcgga aattgatgtc ggtttgttct cactttccgc
    12121 aagtcattcg tcgcataact ttcctggaaa gctgttagga tatatggtgc aatcagttcc
    12181 cattttagga agcgttaatg cgggtaatga ccttgcggat ttggtgaata acagtggtgc
    12241 cggatttatt cacattaatg gcgaggatga taaactgctc cattcggcta agcgtttgtt
    12301 attagaaccc gagttgcgga ataagttagg cgatgcggct aatactttgt tacatgagca
    12361 attttcggta actgctgctg caaagtcaat tgaacaaaga ctggaggctg attatgcgtg
    12421 tcatcacttg taccgagttg catgagttat atgataatgc cagaaaatca gaaagactgc
    12481 gtgcacattt gctattgcat tcttgtcatg atgacaaagt tcagcgccta tttattggca
    12541 tggttaaggg cagttatgtt gaaccccatt ttcatgaatt gccacatcag tgggaaatgt
    12601 ttattgttat ggaaggccag ataaaggttt gtctctacaa tcaatcggga gcgatcgtga
    12661 gggcatttgt tgccggtgac gatgctgata gttctgtcgt ggaatttgct ccgggagata
    12721 tacatagcgt agagtgtatc tctgagcaag cactgatgat ggaggttaag gaaggcccgt
    12781 ttgactcgaa ttatgccaag gtgtttccga attggtaatt aatgtttctt atcgaaaata
    12841 ataatgctga tatttgatct tttttatcat ttcacatgac ccctgattgt ctggagcatc
    12901 ttccgctatc cccaaagcct gaaactgagt taacatctac gatacattga acccgcgcat
    12961 gcgtcgcgcg gtgaccacac cagacaggag taaacaatgt caaagcaaca gattggcgtc
    13021 gtcggtatgg cagtgatggg acgcaacctt gcgctcaaca tcgaaagccg tggttatacc
    13081 gtctctattt tcaaccgttc acgtgaaaag acggaagaag tgattgccga aaatccaggc
    13141 aagaaactgg ttccttatta tacggtgaaa gaatttgttg aatctcttga aacgcctcgt
    13201 cgcatcctgt taatggtgaa agcaggtgca ggcacggatg ctgctattga ttccctcaag
    13261 ccatacctcg ataaaggcga catcatcatt gatggtggta ataccttctt ccaggacact
    13321 attcgtcgta accgtgagct ttctgctgaa ggctttaact tcatcggtac gggtgtttcc
    13381 ggtggtgagg agggtgcact gaaaggtcct tccatcatgc ctggtggtca gaaagaagcc
    13441 tatgaactgg ttgcaccgat cctgaccaaa atcgctgctg tggctgaaga tggcgaaccg
    13501 tgcgttacct atattggtgc cgatggtgca ggtcactatg tgaagatggt tcacaacggt
    13561 attgaatacg gcgatatgca gctgattgct gaagcctatt ctctgcttaa aggtgggctg
    13621 aacctctcca atgaagaact tgcacacacc tttaccgact ggaataacgg tgaactgagc
    13681 agctacctga tcgacatcac caaagacatc ttcactaaaa aagatgaaga cggtaactac
    13741 ctggttgatg tgatcctgga tgaagcggct aacaaaggta ccggtaaatg gaccagccag
    13801 agtgcgctgg atctcggcga accgctgtcg ctgattaccg agtctgtgtt tgcacgttat
    13861 atctcttcac tgaaagagca gcgcgttgcc gcgtctaaag ttctctctgg cccgaaagca
    13921 cagccggcag gtgacaaggc tgagttcatc gaaaaagttc gtcgtgcgct gtatctgggc
    13981 aaaatcgttt cttacgccca aggcttctct caactgcgtg ctgcgtctga agagtaccac
    14041 tgggatctga actacggcga aatcgcgaag attttccgtg ctggctgcat catccgtgcg
    14101 cagttcctgc agaaaatcac cgatgcttat gccgaaaatc cgcagatcgc taacctgctg
    14161 ctggctccgt acttcaagca aatcgccgat gactaccagc aggcgctgcg cgatgtcgtc
    14221 gcttacgcgg tacagaacgg tatcccggtt ccgaccttcg ccgctgcggt tgcctattat
    14281 gacagctacc gcgccgctgt tctgcctgcg aacataatcc aggctcagcg tga
//
