LOCUS       LC177550               19035 bp    DNA     linear   BCT 15-DEC-2018
DEFINITION  Escherichia coli DNA, O-antigen biosynthesis gene cluster OgN13,
            strain: E1682.
ACCESSION   LC177550
VERSION     LC177550.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., von Mentzer,A., Kikuchi,T. and Thomson,N.R.
  TITLE     An untypeable enterotoxigenic Escherichia coli represents one of
            the dominant types causing human disease
  JOURNAL   Microb Genom 3 (2017) In press
  REMARK    DOI:10.1099/mgen.0.000121
            Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 19035)
  AUTHORS   Iguchi,A., von Mentzer,A. and Thomson,N.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2016) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuenkibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..19035
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="E1682"
                     /db_xref="taxon:562"
                     /note="Escherichia coli O-antigen biosynthesis gene
                     cluster OgN13"
     gene            14..1408
                     /gene="wcaM"
     CDS             14..1408
                     /gene="wcaM"
                     /codon_start=1
                     /transl_table=11
                     /product="colanic acid biosynthesis protein"
                     /protein_id="BAV90473.1"
                     /translation="MPFKKLSRRTFLTASSALAFLHTPFARALPARQSVNINDYNPHD
                     WIASFKQAFSEGQTVVVPAGLVCDNINTGIFIPAGKTLHILGSLRGNGRGRFILQDGS
                     QVTGEEGGSMHNITLDVRGSDCTIKGLAMSGFGPVTQIYIGGKNKRVMRNLTIDNLTV
                     SHANYAILRQGFHNQIIGANITNCKFSDLQGDAIEWNVAINDSDILISDHVIEHINCT
                     NGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKHFVIRNIK
                     ARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYLSIPQNF
                     RVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFMRNIKV
                     MQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNERGQSSVDIDRINHHIV
                     NVEKINFRLPERRE"
     gene            1571..2476
                     /gene="galF"
     CDS             1571..2476
                     /gene="galF"
                     /note="OgN13_1"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAV90474.1"
                     /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYI
                     VDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVT
                     IMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNE
                     TGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGR
                     YVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQA
                     FVKYGLRNLKEGAKFRKGIEKLLSE"
     gene            2847..3932
                     /gene="rmlB"
     CDS             2847..3932
                     /gene="rmlB"
                     /note="OgN13_2"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6 dehydratase"
                     /protein_id="BAV90475.1"
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLA
                     DVSDSERYVFEHADICDAAAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARNYWSALDSDKKNSFRFHHISTDEVYGDLPHPDEVNNNEELPLFTETTA
                     YAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KALPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDL
                     LDEIVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTVEWY
                     LSNTKWVDNVKSGAYQSWIEQNYEGRQ"
     gene            3932..4831
                     /gene="rmlD"
     CDS             3932..4831
                     /gene="rmlD"
                     /note="OgN13_3"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="BAV90476.1"
                     /translation="MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPE
                     GVAETVRSIRPDIIVNAAAHTAVDKAESEPEFAQLLNATSVEAIAKAANEVGAWAIHY
                     STDYVFPGTGEIPWQEADATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
                     NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVAS
                     GTTTWHDYAALVFEEARKAGIPLALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFA
                     LVLPDWQVGVKRMLNELFTTTAI"
     gene            4889..5767
                     /gene="rmlA"
     CDS             4889..5767
                     /gene="rmlA"
                     /note="OgN13_4"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="BAV90477.1"
                     /translation="MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTL
                     MLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGG
                     DDCALVLGDNIFYGHDLPKLMDAAVNKESGATVFAYHVNDPERYGVVEFDKKGTAISL
                     EEKPLQPKSNYAVTGLYFYDNGVVEMAKNLKPSARGELEITDINRIYMEQGRLSVAMM
                     GRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAYRKGFIDAEQVKVLAEPL
                     KKNAYGQYLLKMIKGY"
     gene            5772..6305
                     /gene="rmlC"
     CDS             5772..6305
                     /gene="rmlC"
                     /note="OgN13_5"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="BAV90478.1"
                     /translation="MNVIKTEIPDVLIFEPKVFGDERGFFFESFNQKVFEEAVGRKVE
                     FVQDNHSKSSKGVLRGLHYQLEPYAQGKLVRCAVGEVFDVAVDIRKSSPTFGKWIGVN
                     LSAENKRQLWIPEGFAHGFLVLSETAEFLYKTTNYYNPQSDRGIIWNDPSLNIKWPLA
                     EKPILSKKDSEQKKIEV"
     CDS             6314..7177
                     /note="OgN13_6"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf7"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90479.1"
                     /translation="MISRLNKILKKFVPNILILYRRYNIIFGRYPNLLIPKSFNEKVL
                     YRMLRYNATFSRLSDKLAVRDYVANVIGDEYLTKIKWDGDYLTRAVFESISPPYIIKA
                     NHGSGTNLIVWDHDIDYEYIETKTKEWLKTDFSKINLEKHYKNIKPRLFIEELLMLDN
                     GKIPSDYKVHCFNAAGKYFIQVDYDRFEEGGGKHTRNIYDESWNKLNLKIAHDNNKYV
                     EKKPELLDEILSLSKKLSQKFNYVRVDWYLVNNKLYFGEMTFTHGAGTELFEPAYMDR
                     IWGTYWGNEKG"
     gene            7164..8363
                     /gene="wzx"
     CDS             7164..8363
                     /gene="wzx"
                     /note="OgN13_7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAV90480.1"
                     /translation="MKKAKNEFVSNLIGLGSVNVLNLIIPIITMPILSRALGGDGYGI
                     VLLFSSVTIFMMIIVDYSVNINGVRDVALNPNSLESIYIRFQGVRCLFGMVYFPLAVL
                     YCYYNISEINFNNIVELLFVSIIGYYFMAPWFHQGTGTLIFFSGVSTVLRLLQILLII
                     IFVKDRADLLYALRINAYVFLVNGVLLYLYRKFKFDFSFSIINPFKLKEIKNGFGNFI
                     GDFSPNLYSNLPPLILGGLVSSNIFASYSLALRLINVAGSFQSIICRSMYPIAAKRKI
                     NVNAFLLINIVLSLVPIIFILTSSDFLIEWFLGNGFDEAALFLKLGTLGILFYAISSS
                     LMFAYVLPNNHDALFRKISLFSSIVPAIVGYPLIYLFGALGAISMFIFARFCFAILYL
                     FNYLKLK"
     CDS             8366..9139
                     /note="OgN13_8"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf9"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90481.1"
                     /translation="MDKDIVVYTSLFGDYDELTEVSEPDLECEYICFTDQINLKSKTW
                     KIIIIKHNNESAYMNRMYKILPHRFLSEYKASLYVDSNIILKKNMSQIIRHYTTLSNI
                     SIPKHFMRNCIYEEALFCLRTNKIDKIIYERLINQYYLLNKFPKGYGMGENNIIIRKH
                     NSPEIIEAMEQWWLFYVNIAKRDQLSLMFILWLKNVNFMLMQETSRNKNDYFDYKLHK
                     HLISKSKVKTFLRSASARRDRNLLFKLIGKIMDNCKGYK"
     gene            9136..10203
                     /gene="wzy"
     CDS             9136..10203
                     /gene="wzy"
                     /note="OgN13_9"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAV90482.1"
                     /translation="MIIYNIIFFSILTLSLPTFYSLHKTKLSNVIYFAISILLIMFAA
                     FRGDIDRDHQNYINIYGYILNGQLYLIEPTFYLFTYISKWIANDYYFLFIIYAFIGVL
                     CKLFVINKYSYVPLLSLLVYYSNSFFLHEMTQIRVGVAVGLCFLSLSFLIRKNNLAYC
                     LIVGLATLFHYSACLFFIFLISPKGVIKNKELLFYGIVLIAAYILYAFNIGLANIFSY
                     IPIGFIKQKFIEYSDKTAGGLVIDVNVFSTLQIIRIICTIIIVYYVKRNTVPELTFIL
                     LRIYIISIIAWVLFFDIPAFAIRVSELLGFAEVILLPYLAKSFKPKIFGIIVFVLVCC
                     VMYYINLYHNEMLLPYSLLGE"
     CDS             10200..11042
                     /note="OgN13_10"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf11"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90483.1"
                     /translation="MMKILPVIVLYKKKIEECESLFSLIKMDGILTYIDTIYIHDNSA
                     NENQPIKKYGTFKVKYYGDGYNHGVSKAYNDACRYAKENGYTWLLLLDQDTQFPENAL
                     NEYCCGINSYPGLPLYVPVLRTKDDIICSPCAYRWHRGFTPRQLKIGVNSLNEFSPIN
                     SGMLIRVESFIAAGGYNEKVYLDFSDFQFIERVRIVQDKFCIINLEAKQDFSNDTNDV
                     RSLISRFKIYCECALNCEKKTIIDKIQYASIVFARTSKLFIRTKNIEFFKIFFMQYIF
                     KGES"
     CDS             11039..11779
                     /note="OgN13_11"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf12"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90484.1"
                     /translation="MISVCMATYNGGEYVYTQLNSILKQLGRNDELIISDDGSTDNTI
                     NIIEKYNDPRIKLIRHDRGWLDPKTPLLSRVKKNFEEAIRLATGEFIFLSDQDDIWLP
                     GRVEECLAEFKNGFDLIVCDCIVTDKNKILFSSYYEIIKPSSNILRTLYKSSFHGCCL
                     AFSRKMNHYILPMPNENIGHDIWIGLQCIINGKVKFIDKQLVNYRRHDDTVTQCGFKS
                     TNKLKDKIIYRLAILTALCKRKYISCLK"
     CDS             11767..12909
                     /note="OgN13_12"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf13"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90485.1"
                     /translation="MPKIAHVQVIPKLSGAQRFSLNILSKLDDYDKFIICSGREEVSK
                     EQLYSFINQMKKMNINIIWAPSLQRRIGIHDIKCFFELYSIFKKYNFDIVHTNSTKPG
                     IVARIAARIAGVKKIIHTVHGIAFHSNESIFKKIFYYLVEAIALQFGSYNVTVNNYYL
                     RYYKLFFWKKSLRIYNGVDFSAIERSLTNKGEKNPDERTVKKILFVGRLDKQKNPLTA
                     LRAFKYLIQKNSNVIFDVVGDGELRKECETYVIENNLESKVFFHGWVEEPSSFYNNAD
                     IFYCPSSYEAFGFTFVEAAFFGLPIIASNVEGIPEVVIHGKMGFLTAPDDYIDQANFI
                     ERLLYDNELYEEFSKYGKKYVVNNFSLPTSLSSYISLYNETCGKKK"
     gene            13015..14421
                     /gene="gnd"
     CDS             13015..14421
                     /gene="gnd"
                     /note="OgN13_13"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAV90486.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            14643..15836
                     /gene="ugd"
     CDS             14643..15836
                     /gene="ugd"
                     /note="OgN13_14"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAV90487.1"
                     /translation="MFNRKKSELMKITISGTGYVGLSNGILIAQNHEVVALDIVQAKV
                     DMLNKKQSPIVDKEIEEYLATKDLNFRATTDKYDAYKNADYVIIATPTDYDPKTNYFN
                     TSSVEAVIRDVTEINPNAVMIIKSTIPVGFTESIKERFGVENVIFSPEFLREGKALYD
                     NLHPSRIVIGEQSERAERFAALLQEGAIKQDIPTLFTDSTEAEAIKLFANTYLAMRVA
                     YFNELDSYAESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQS
                     VPNNLISAIVDANRTRKDFIADSILARKPKVVGVYRLIMKSGSDNFRASSIQGIMKRI
                     KAKGVPVIVYEPAMKEDDFFRSRVVRDLDAFKQEADVIISNRMSADLADVADKVYTRD
                     LFGND"
     CDS             complement(15902..16906)
                     /note="OgN13_15"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf16"
                     /product="NAD-dependent epimerase"
                     /protein_id="BAV90488.1"
                     /translation="MKFLVTGAAGFIGFYVSKRLLAAGHQVVGIDNLNDYYDVNLKQA
                     RLDLLKHDNFSFYKIDLADREKMAALFADERFERVINLAAQAGVRYSLENPNAYADAN
                     LIGFLNILEGCRHNNVQHLLYASSSSVYGMNRKMPFSTDDSVDHPVSLYAATKKANEL
                     MAHTYSHLYGLPTTGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNFGKMKRDFT
                     YIDDIAEAIIRLQDVIPEKNPQWAVETGSPATSSAPYRVYNIGNSSPVELMDYINALE
                     EALGIEANKNMMPLQPGDVLETSADTKALYDVIGFKPETSVKEGVKNFVEWYRNFYKV
                     "
     gene            17258..18292
                     /gene="wzz"
     CDS             17258..18292
                     /gene="wzz"
                     /note="OgN13_16"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAV90489.1"
                     /translation="MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLV
                     QLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYTNAMNVIYGS
                     AVPKVSDIQASLIGRYSTAFSALAETLDNQEEAEKLTIEPTVKNQSLPLAVSYVGETP
                     EGAQKQLAKYIQQVDDQVNEELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQ
                     IQEALQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSSNYYQT
                     RQNLLDIDNLDVDKLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLG
                     RNALRNYNAK"
     gene            complement(18389..19000)
                     /gene="hisI"
     CDS             complement(18389..19000)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAV90490.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ"
BASE COUNT     5734 a   3487 c   4136 g   5678 t
ORIGIN
        1 tagaggagaa cgtatgccat ttaaaaaact ctcccgacgc accttcctga cggcaagctc
       61 ggcccttgcc ttcctccata cccctttcgc tcgcgcactt cccgcccgac aaagcgttaa
      121 cattaacgac tacaaccctc acgactggat cgcctcattt aaacaagcct tcagcgaagg
      181 gcaaacggtc gtcgtgcctg ccggattggt ttgcgacaat atcaacaccg gcatcttcat
      241 tcctgcaggt aaaacgttac acatccttgg aagcctgcgc ggcaacggca gagggcgatt
      301 tatcttacag gacggcagcc aggtgacagg ggaggagggc ggcagtatgc ataacatcac
      361 cctggatgtg cgaggctctg actgcaccat caaagggctg gcgatgagcg gctttggccc
      421 ggtaacgcag atttatatcg gcggcaaaaa caaacgggtc atgcgtaacc tgaccatcga
      481 taacctcact gtcagccacg ctaattacgc catcttacgc cagggatttc ataaccagat
      541 tatcggtgcc aacatcacca actgtaagtt cagcgactta cagggggacg ctattgaatg
      601 gaacgtggcg attaacgaca gtgatatttt gatctccgac catgtcatcg agcacatcaa
      661 ctgtaccaac ggcaaaatca actggggcat cggtataggc cttgcgggaa gcacttacga
      721 taataattac ccggaagacc aggcagtgaa aaactttgtc gtggcgaata tcacgggatc
      781 ggattgtcgg cagttgatcc atgttgaaaa tggtaaacat tttgttattc gtaatatcaa
      841 agcccgcaat atcacgccgg atttcagtaa gaaagcaggt attgataacg ctacggtcgc
      901 tatttacggt tgtgacaatt tcgtgattga taatattgaa atgattaata gcgccgggat
      961 gttaatcggc tatggggtaa ttaaaggcaa atatctctcg ataccgcaaa atttccgagt
     1021 gaataatatt caactggata acacccatct tgcttataaa ttgcgcggta tccaaatctc
     1081 cgccgggaat gccgtctcct ttgtggcact gactaacatt gagatgaagc gtgcctcgct
     1141 tgagctgcac aacaagccgc aacatctttt tatgcgtaat atcaaagtga tgcaggaatc
     1201 ctctgttgga cccgcattga gcatgaactt cgacatgcgc aaagacgttc gcggcgtctt
     1261 tatggcgaaa aaagaaacac tgctatctct tgcaaatgtt catgcggtga atgaaagagg
     1321 gcaaagctcc gtcgatatcg acaggattaa tcaccatatt gttaatgtgg aaaagattaa
     1381 ctttagattg ccggaacgga gagagtagat ttgcgaccat tcctggaaaa atggagccat
     1441 acttaggaac aatgctactg caatccacaa cgaagcggcg taacatcaca agtaattcag
     1501 taatcaattc aaggtaattg atgctggcga aaaaaatcga acaagctata attcagcaac
     1561 cattttacag gtggatgaaa taatgacgaa tttaaaagca gttattcctg tagcgggtct
     1621 tgggatgcat atgttgcctg ccactaaggc gattcccaaa gagatgctac cgatcgtcga
     1681 caagccaatg attcagtaca ttgttgacga gattgtggct gcagggatca aagaaatcct
     1741 cctggtaact cacgcgtcca agaacgcggt cgaaaaccac ttcgacacct cttatgaatt
     1801 agaatctctc cttgaacagc gcgtgaagcg tcagctgctg gcggaagtgc agtccatctg
     1861 tccgccgggt gtgaccatta tgaacgtgcg tcagggcgaa cctttaggtt tgggccactc
     1921 cattttatgt gcacgacccg ccattggtga caacccattt gtcgtggtgc tgccagacgt
     1981 tgtgatcgac gacgccagcg ccgacccgct gcgctacaac cttgctgcca tgattgcgcg
     2041 cttcaacgaa acaggacgca gccaggtgct ggcaaaacgt atgccgggtg acctctctga
     2101 atactccgtc attcagacca aagaaccgct ggatcgcgaa ggcaaagtca gccgcatcgt
     2161 ggaatttatc gaaaaaccgg atcagccgca gacgctggac tcagacatca tggccgtggg
     2221 tcgctatgtg ctttctgccg atatttggcc ggaacttgaa cgcactcagc ctggtgcatg
     2281 ggggcgtatt cagctgactg atgccatcgc tgaactggcg aaaaaacagt ccgttgatgc
     2341 catgctgatg acaggtgaca gctacgactg cggtaaaaaa atgggttata tgcaggcatt
     2401 tgtgaagtat ggactacgca acctcaaaga aggggcgaag ttccggaaag ggattgagaa
     2461 gctgttaagc gaataatgaa aatctgaccg aatgtaacgg ttgataagaa aattataacg
     2521 gcagtgaaga ttcgtggcga aagtaatttg ttgcgaatat tcctgccgtt gttttatata
     2581 aacaatcaga ataacaacga gttagcaata ggattttagt caaagttttc caggattttc
     2641 cttgtttcca gggcggattg gtaagacaat tagcgtttga atttttcggg ttaagcgcga
     2701 gtgggtaacg ctcgtcacat cgtagacatg catgcagtgc tctggtagct gtaaagccag
     2761 gggcggtagc gtgcattaat acctctatta atcaaactga gagccgctta tttcacagca
     2821 tgctctgaag aatatggaat aataaagtga agatacttgt tactggtggc gcaggattta
     2881 ttggttctgc tgtagttcgt cacattataa ataatacgca ggatagtgtt gttaatgtcg
     2941 ataaattaac gtacgccgga aacctggaat cgcttgctga tgtttctgat tctgaacgct
     3001 atgtttttga acatgcggat atttgcgatg cagctgcaat ggcacggatt tttgctcagc
     3061 atcagccgga tgcagtgatg cacttggctg ctgaaagcca tgttgaccgt tcaattacag
     3121 gtcctgcggc atttattgaa accaatattg ttggtactta tgtccttttg gaagccgctc
     3181 gcaattactg gtctgctctt gatagcgaca agaaaaatag cttccgtttt catcatattt
     3241 ctactgacga agtctatggt gatttgcctc atccagatga agtaaataat aacgaagaat
     3301 tacccttatt tactgagacg acagcttacg caccaagcag cccttattcc gcatcaaaag
     3361 catccagcga tcatttagtc cgggcgtgga aacgcaccta tggtttaccg accattgtga
     3421 ctaactgttc gaataactac ggtccttatc actttccgga aaaattgatt ccactagtaa
     3481 ttcttaatgc tctggaaggt aaggcattac ctatttatgg caaaggggat caaattcgtg
     3541 actggctgta tgttgaagat catgcgcgtg cgttatatac cgtcgtaacc gaaggtaaag
     3601 cgggtgaaac ttataacatt ggtggacaca acgaaaagaa aaacatcgat gtagtgctca
     3661 ctatttgtga tttgttggat gagattgtac cgaaagagaa atcttatcgt gagcaaatta
     3721 cttatgttgc cgatcgcccg ggacacgatc gccgttatgc cattgatgca gagaagatta
     3781 gccgcgaatt gggctggaaa ccgcaggaaa cgtttgagag cgggattcgt aaaacggtgg
     3841 aatggtacct gtccaataca aaatgggttg ataatgtgaa aagtggtgcc tatcaatcgt
     3901 ggattgaaca gaactatgag ggccgccagt aatgaatatc ctccttttcg gcaaaacagg
     3961 gcaggtaggt tgggaactac agcgtgctct ggcacctctg ggtaatttga ttgctcttga
     4021 tgttcactcc actgattact gtggtgattt tagtaatcct gaaggtgtag ctgaaaccgt
     4081 aagaagcatt cggcctgata ttattgtcaa cgcagccgct cacaccgcag tagacaaagc
     4141 agaatcagaa ccggagtttg cacaattact taacgcgacg agtgtcgaag cgatcgcgaa
     4201 agcagccaat gaagtcggcg cctgggctat tcactactct actgactacg tatttccggg
     4261 aacaggtgaa ataccatggc aggaggcgga tgcaaccgca ccgctgaacg tttatggaga
     4321 aaccaagtta gccggagaaa aagcattaca agagcattgt gcgaagcacc ttattttccg
     4381 gaccagctgg gtctatgcag gtaaaggaaa taacttcgcc aaaacaatgt tgcgtctggc
     4441 aaaagagcgc gaagaactag ccgttattaa tgatcagttt ggtgcgccaa cgggcgcaga
     4501 gttgctggct gattgtacgg cacatgcaat tcgtgtggca ctgaataaac cagaagtcgc
     4561 aggcttgtat catctggtag ccagtggtac cacaacctgg cacgattatg ctgcgctggt
     4621 ttttgaagag gcgcgcaaag caggcattcc ccttgcactc aacaagctca atgcagtacc
     4681 aacaacagcc tatcctacac cagcccgtcg cccccataac tctcgtctta atacagaaaa
     4741 atttcagcag aactttgcgc ttgtcttgcc tgactggcag gttggtgtga aacgaatgct
     4801 caacgaatta tttacgacta cagcaattta atagtttttg catcttgttc gtgatggtgg
     4861 agcaagatga attaaaagga atgatgaaat gaaaacgcgt aaaggtatta ttttagcggg
     4921 tggttctggt acacgtcttt atcctgtgac tatggctgtc agtaaacagc tattacctat
     4981 ttatgataag ccgatgatct attacccgct ttctacactg atgttagcgg gtattcgcga
     5041 tattctgatt atcagtacgc cgcaggatac tcctcgtttt caacaactgc tgggtgacgg
     5101 gagccagtgg gggctaaatc ttcagtataa agtgcaaccg agtccagatg gtcttgcgca
     5161 ggcatttatc atcggtgaag agtttattgg tggtgatgat tgtgctttgg ttctaggtga
     5221 taacatcttt tacggtcacg atctgccgaa gttaatggac gcagctgtta acaaagaaag
     5281 tggtgcaacg gtatttgcct atcacgttaa tgatcctgaa cgctacggtg tcgttgagtt
     5341 tgataaaaaa ggtacggcaa ttagcctgga agaaaaaccg ttacaaccaa aaagtaatta
     5401 tgcggtaacc gggctttatt tctatgataa cggcgttgtg gaaatggcga aaaaccttaa
     5461 gccttctgcc cgtggtgaac tggaaattac cgatattaac cgtatttata tggaacaggg
     5521 gcgtttatcc gttgccatga tggggcgtgg ttatgcatgg ctggacacgg ggacacatca
     5581 gagtcttatt gaagcaagca acttcattgc aacaattgaa gagcgccagg gactaaaggt
     5641 ttcctgcccg gaagaaattg cttaccgtaa agggtttatc gatgctgagc aggtgaaagt
     5701 attagctgaa ccgctgaaaa aaaatgctta tggtcaatat ctgctgaaaa tgattaaagg
     5761 ttattaataa aatgaacgta attaaaacag aaattccaga tgtacttatt tttgaaccga
     5821 aagtttttgg tgatgagcgt ggtttctttt ttgagagctt taaccagaag gtttttgagg
     5881 aagctgtagg ccgcaaagtt gaatttgtcc aagataacca ttcgaagtct agtaaaggtg
     5941 ttttacgcgg gctgcattat cagttagaac cgtatgcgca aggaaaattg gtacgttgcg
     6001 ctgttggtga ggtttttgac gtagcggttg atattcgtaa atcgtcacca acttttggca
     6061 aatggattgg agtgaattta tctgctgaga ataagcgcca gttgtggata cctgaaggat
     6121 tcgcacatgg gtttttggtg ctgagtgaaa cggcggagtt tttgtataag acgacgaatt
     6181 attataatcc gcagagtgat aggggcatta tatggaatga tccaagttta aatataaagt
     6241 ggccattagc ggaaaaacct atcctttcca aaaaggattc tgagcaaaaa aaaatagaag
     6301 tgtaagagaa aaaatgatta gcagattaaa taaaatattg aaaaaattcg tacctaatat
     6361 tttaatttta tatcgcaggt ataatataat atttggtcga tatcccaatt tattaatacc
     6421 aaaaagtttt aatgaaaagg tgttatatcg tatgcttcga tataatgcta cgtttagcag
     6481 actatctgat aaattggctg taagagatta tgtggcgaat gtaattggag atgaatactt
     6541 aacaaaaatc aaatgggatg gggattattt aactagggct gtatttgaat caatatcgcc
     6601 tccttatata ataaaggcaa atcatggcag tggtactaat ctgatcgtat gggatcatga
     6661 tatcgactat gaatatatag aaacgaaaac aaaggaatgg ttaaagactg atttttcaaa
     6721 aataaatctt gaaaagcatt ataaaaatat taagcctcgc ttatttattg aggaattact
     6781 gatgctcgat aatggaaaaa ttccttcgga ttataaggta cattgcttta atgctgcagg
     6841 gaagtatttt attcaagtag attatgatag atttgaagag ggggggggga aacacacaag
     6901 aaatatatat gatgaatcat ggaataaact aaatcttaag atcgcacatg ataataataa
     6961 atatgtagaa aagaaaccag agttattgga tgaaattttg tctttatcta aaaaattaag
     7021 tcaaaaattt aattatgtga gagttgattg gtatttagta aataataagc tctactttgg
     7081 tgaaatgact tttactcatg gtgcgggaac ggaattattt gaacctgctt atatggatcg
     7141 aatatggggt acatactggg gaaatgaaaa aggctaaaaa cgagtttgtg agcaatctga
     7201 ttggtttagg ttctgttaat gttcttaatc tgataatacc aataataaca atgccgattt
     7261 tatcaagagc attgggggga gatggatatg gaatagtttt gctatttagt agtgtgacca
     7321 tttttatgat gattattgta gattatagcg taaatataaa tggagttcgt gatgttgctt
     7381 taaatccgaa ttctcttgaa tcaatttata tccgattcca aggagtaagg tgtctcttcg
     7441 gaatggtata ttttccactc gctgtattat attgttatta taatatatca gaaatcaatt
     7501 tcaacaatat agttgaactg ctttttgtaa gcataattgg ttattatttt atggcacctt
     7561 ggtttcatca aggaacagga accttaatat ttttttctgg agtttcaaca gtattaaggt
     7621 tgttacagat tttgctaata ataattttcg ttaaagatcg tgcggatctc ttatatgcat
     7681 taaggataaa tgcttatgta tttttagtaa atggagtctt gttatatttg tatagaaaat
     7741 ttaagtttga ttttagtttc tcaataatca atccttttaa attgaaagaa ataaaaaatg
     7801 gatttggaaa cttcattggt gactttagtc caaatctata tagtaatctt cctccattaa
     7861 tcttaggtgg actagtatcg tcaaatatat ttgcaagtta ttcattagca ttgaggttga
     7921 taaatgttgc tggaagtttt caatcaatca tatgcagatc aatgtaccct attgcagcca
     7981 aaagaaaaat taatgtaaat gcttttctac tgattaatat tgtattatca ttggtcccta
     8041 ttatttttat attgacaagt tctgatttcc tcattgaatg gtttctaggt aatggtttcg
     8101 atgaagccgc tctatttcta aaattaggca cgttgggaat attattttac gcaatatcat
     8161 cttcactaat gtttgcatat gtattaccaa ataatcatga tgctctcttt aggaaaatat
     8221 cactattttc ttctatagtc cctgcgatag tagggtaccc actcatatat ttatttggcg
     8281 ctctcggcgc aatttcaatg tttatttttg caaggttttg ctttgcaata ttatatttgt
     8341 ttaattactt aaagttgaaa taacagtgga taaagatatc gttgtatata catccctttt
     8401 tggggattat gatgagctta cagaagtatc agagcctgat cttgaatgtg aatatatatg
     8461 tttcacagat caaattaatt tgaaatctaa aacatggaaa attattataa taaaacataa
     8521 taatgaatca gcatatatga atagaatgta taaaatctta ccgcatagat ttttatctga
     8581 atacaaggca tcattatacg ttgactcgaa tattatatta aagaaaaaca tgtcacaaat
     8641 aattcggcac tatacaacgc tatctaatat ttcaatccct aaacatttta tgcggaattg
     8701 tatatacgaa gaagcattat tttgtttaag aacaaataaa attgataaga tcatatatga
     8761 acgattaatt aatcaatatt atttattgaa taaatttcct aagggatatg gaatgggaga
     8821 aaataatata ataattagaa aacataatag tccagaaata atagaagcaa tggaacaatg
     8881 gtggttattt tacgttaata tagcaaaacg ggatcagcta agtcttatgt ttattctttg
     8941 gcttaagaac gttaatttca tgttgatgca agagacatca cgtaataaaa atgattattt
     9001 tgattataag ctacataagc atcttatatc aaaatcaaag gttaaaacat ttcttcgtag
     9061 tgcatctgca agacgtgatc gaaatttatt atttaaatta atcggtaaaa taatggataa
     9121 ttgtaaagga tataaatgat aatttataac attattttct tctcaatttt gactttatca
     9181 ttacccacgt tttattcgtt acataaaact aaattaagca acgtaatata ctttgccata
     9241 agtattttac ttattatgtt cgctgcattt agaggagata ttgatagaga tcatcaaaat
     9301 tatattaata tatatgggta tattttaaat ggccaacttt atctgattga gccaactttt
     9361 tatttattca cttatatttc taaatggatt gcaaacgatt attatttttt atttataata
     9421 tatgcattca taggcgtgtt atgtaagcta tttgtaatta ataaatatag ttatgtacca
     9481 ttgttgtcat tgttagttta ttattcaaat agtttctttt tgcatgagat gacacaaatt
     9541 agagttggtg tggcagttgg attatgtttt ctaagtttgt cattcttaat aagaaaaaat
     9601 aatttagcat attgtttgat agttggtctg gcaacattat ttcattattc agcatgcctt
     9661 ttctttattt ttttaatttc acctaaagga gttataaaga acaaagagct tttgttttat
     9721 ggtattgtat tgattgctgc gtatatatta tatgcattta atatagggtt agcgaatata
     9781 ttctcatata tccctattgg ttttataaaa caaaagttta tcgaatatag cgacaaaact
     9841 gccggcgggt tagtaataga cgttaatgtg ttcagtacgc ttcaaataat aaggattatc
     9901 tgtacaataa ttattgtata ttatgtgaaa agaaatactg ttcccgaatt gacttttata
     9961 ttattgcgaa tttatattat atcaataatc gcatgggtct tattttttga tatacctgct
    10021 tttgcaatca gggtttcaga gttgttagga tttgctgagg tcattttatt gccttattta
    10081 gccaaatcat ttaaaccaaa aatatttggg attatagtgt ttgttttagt atgctgtgtt
    10141 atgtattata tcaacctata tcataatgaa atgttactgc cgtattcttt attaggtgag
    10201 tgatgaaaat tttacccgtt attgtattat ataaaaaaaa gatcgaagaa tgtgaaagct
    10261 tattttcgtt aattaaaatg gatgggattt taacgtatat tgatactata tatattcatg
    10321 ataattctgc gaatgaaaat caaccaataa aaaaatatgg aacttttaaa gttaaatact
    10381 atggtgatgg ttataatcat ggagttagta aggcatacaa tgacgcatgt cggtatgcta
    10441 aagaaaatgg ttatacatgg ttgctactcc ttgatcaaga tacacagttc ccagaaaatg
    10501 cattaaatga atattgttgt gggataaatt cctatccagg cttgccttta tatgtccctg
    10561 ttttacgaac aaaagatgat attatatgct caccatgtgc gtatagatgg catagaggat
    10621 tcactcctag acaactaaaa attggtgtta attcacttaa tgaattctca ccaataaata
    10681 gtggaatgtt aatacgtgta gaaagcttca ttgcggcagg tggatacaat gagaaggtgt
    10741 atttagattt tagtgatttt cagtttatag aaagagtacg aattgtacaa gataagtttt
    10801 gcataatcaa tcttgaagca aaacaagatt tttcaaatga tacaaatgat gttagatcat
    10861 tgatttcaag attcaaaata tattgtgagt gcgcattaaa ttgcgaaaaa aaaactataa
    10921 ttgataaaat tcaatatgca agcattgtat tcgcacgcac atcaaaactt tttattagaa
    10981 caaaaaatat agagtttttt aaaattttct ttatgcagta tatttttaag ggggaatcat
    11041 gatatcagtc tgcatggcta cctataatgg tggtgaatat gtttatacac aattgaatag
    11101 catattgaaa caactgggta gaaatgatga gctaattata tctgatgatg gaagtacaga
    11161 taatactata aatattatag agaagtataa tgatccaaga ataaaattaa tcagacatga
    11221 tcgggggtgg ttagacccaa aaacaccact tttatctcgt gtaaagaaaa attttgaaga
    11281 ggctatacgt ttagccacag gagagtttat ttttttgtct gaccaggatg acatttggct
    11341 tcctggaaga gttgaagaat gtttggctga gttcaaaaat ggatttgact taatagtctg
    11401 tgattgcata gttacagata aaaataaaat attattctct tcctattatg agatcataaa
    11461 acctagtagc aatatattgc gtacattata taaaagttct tttcatggtt gttgcctagc
    11521 attcagtaga aaaatgaacc attacatcct ccctatgcca aatgagaata taggacatga
    11581 tatatggatt ggtttgcaat gtattattaa tggcaaggta aaatttatag ataagcaact
    11641 tgttaactat cggcgacatg atgatactgt tactcaatgt ggattcaaaa gtactaataa
    11701 attgaaagat aagattatat atagattggc aattttgacc gctttatgta aaaggaagta
    11761 tatttcatgc ctaaaatagc acacgtacaa gttataccta agctttcagg agcacagagg
    11821 ttttctttaa acatattgag caagttggat gattatgaca aatttatcat ttgttcgggg
    11881 agagaagaag tctctaagga acagctatat tcgttcatta atcagatgaa aaaaatgaac
    11941 ataaatataa tatgggctcc aagtctacaa cgacgtatcg gtatccacga cataaaatgt
    12001 ttctttgaat tgtattctat ttttaaaaaa tataactttg atatcgttca tacaaattct
    12061 actaaaccgg gtattgttgc tagaatagct gcgcgtattg ctggtgtcaa aaaaataatc
    12121 catacggtac atggaatagc atttcattca aatgaatcaa ttttcaaaaa aatattttac
    12181 tatttagttg aagctatagc attacaattt ggcagctata atgttactgt gaacaactat
    12241 tatcttaggt attataaatt atttttttgg aaaaaaagct taaggatata taatggagtt
    12301 gatttttctg caatcgagag aagtttaaca aataaaggtg aaaaaaatcc agatgagcgt
    12361 actgtaaaaa aaattctctt tgttggtcgt ttagataagc agaaaaatcc attgaccgca
    12421 ctaagagcat ttaaatattt aatccaaaaa aacagcaatg ttatttttga tgttgtaggg
    12481 gatggtgaat taagaaagga atgtgagacg tatgttattg aaaataattt agagtcaaaa
    12541 gtattttttc atggctgggt agaagaaccg tcatcatttt ataataatgc cgatatattt
    12601 tattgtccat catcatatga agcttttggc tttacatttg tcgaggcggc ttttttcggc
    12661 ttgccaataa ttgcatccaa tgtcgaaggt attccagaag ttgttataca tgggaaaatg
    12721 ggatttttaa ctgctcctga tgactatatt gaccaagcaa atttcattga aaggctttta
    12781 tatgataatg aattatatga agagttttca aaatatggaa aaaaatatgt cgttaacaat
    12841 ttttctttgc caacttcctt aagttcttat ataagcctat ataatgagac ttgcggtaaa
    12901 aaaaagtgaa gtgttaatat ctctacgctt tatgttttta ttcttattat ggcattaaat
    12961 taatatatag tacgccgcat acatcgcggt aatcccccct gacaggagta aacaatgtca
    13021 aagcaacaga tcggcgtcgt cggtatggca gtgatgggac gcaaccttgc gctcaacatc
    13081 gaaagccgtg gttataccgt ctctattttc aaccgttccc gtgaaaagac cgaagaagtg
    13141 attgccgaaa atccaggcaa gaaactggtt ccttactata cggtgaaaga gtttgttgaa
    13201 tctctggaaa cgcctcgtcg catcctgtta atggtgaaag caggtgcagg cacggatgct
    13261 gctattgatt ccctcaagcc atacctcgat aaaggcgaca tcatcattga tggtggtaac
    13321 accttcttcc aggacaccat tcgtcgtaac cgtgagcttt ctgccgaagg ctttaacttc
    13381 attggtaccg gtgtctctgg tggtgaagaa ggcgcgctga aaggtccttc cattatgcct
    13441 ggtgggcaga aagaagccta tgaactggtt gcgccgatcc tgaccaaaat cgccgccgtt
    13501 gctgaagatg gcgaaccgtg cgttacctat ataggtgccg atggtgcagg tcactatgtg
    13561 aagatggttc acaacggtat cgaatacggt gatatgcagc tgattgctga agcctattct
    13621 ctgcttaaag gtggcttgaa cctttccaac gaagaactgg cgcagacctt taccgagtgg
    13681 aataacggtg aactgagcag ctacctgatt gacatcacta aagatatctt cactaaaaaa
    13741 gatgaagacg gtaactacct ggttgatgtg attctggatg aagcagcaaa caaaggtacg
    13801 ggcaaatgga ccagccagag tgcgctggat ctcggcgagc cgctgtcgct gattaccgag
    13861 tctgtgtttg cacgttatat ctcttctctg aaagatcagc gtgttgccgc atctaaagtt
    13921 ctctctggcc cgcaagcaca gccagcaggc gacaaggctg agttcatcga aaaagttcgc
    13981 cgtgcgctgt atctgggcaa aatcgtttct tacgctcagg gcttctctca gctgcgtgct
    14041 gcgtctgaag agtacaactg ggatctgaac tacggtgaaa tcgcgaagat tttccgtgct
    14101 ggctgcatta tccgtgcgca gttcctgcag aaaatcaccg atgcttatgc cgaaaatccg
    14161 cagattgcta acctgctgct ggctccgtat ttcaagcaaa ttgccgatga ctaccagcag
    14221 gcgctgcgtg atgtcgttgc ttatgcggta cagaacggta tcccggttcc gaccttcgcc
    14281 gctgcggttg cctattatga cagctaccgt gccgctgttc tgcctgcgaa cctgatccag
    14341 gcacagcgtg actatttcgg tgcgcatact tataagcgca ttgataaaga aggtgtgttc
    14401 cataccgaat ggctggatta atctgattta aatcgattaa tcaatgcaag gcccggagaa
    14461 accctccggg cttttttatt atacaaagcg gcaggttatg gccttttttt ataatttata
    14521 gttaaaaacg cgatataata cagcgccgca cagcaggatc gctgccttga cagttcatct
    14581 acttcagcgt taaaaatccc gcagtagatg aagttgtggt ggtgggttaa tgaccactct
    14641 aaatgtttaa ccggaagaag tcagagctaa tgaaaataac aatttcagga acaggttatg
    14701 ttggtctttc aaatggtatt ctgattgcgc aaaaccacga agtggttgca ctggatatcg
    14761 ttcaggccaa agtggacatg cttaacaaga agcagtcacc gattgttgat aaggagattg
    14821 aagagtatct ggcgactaaa gatctcaatt tccgcgctac gacagataag tatgatgcgt
    14881 ataaaaatgc cgattacgtt attattgcca cacctaccga ttatgacccg aaaacaaatt
    14941 attttaatac ttcaagcgtg gaagcggtca tccgtgatgt gacagaaatt aatcccaacg
    15001 cggtaatgat tataaaatca actatccctg tcggttttac agagtccatt aaagaacgtt
    15061 ttggtgttga aaatgtgatc ttttcgcctg agtttttacg cgaagggaaa gcactttatg
    15121 ataacttaca cccatcacgc atagtgattg gagagcagtc tgaacgcgct gaacgttttg
    15181 cagcattatt acaagaaggt gctattaagc aagatattcc aacgttgttt actgactcaa
    15241 cggaagctga ggcgattaaa ctttttgcaa acacctatct ggcgatgcgc gtggcgtact
    15301 ttaacgagct ggatagttat gcggaaagtt taggtctgaa tactcgccag attatcgaag
    15361 gcgtttgtct cgatccgcgt attggcaacc attacaacaa tccgtcgttt ggttatggtg
    15421 gttattgtct gccgaaagat accaagcagt tactggcgaa ctaccagtct gtgccgaata
    15481 acctgatctc ggcaattgtt gacgccaacc gcacgcgcaa agattttatt gccgattcta
    15541 tccttgcacg taaaccgaaa gttgttggcg tctatcgttt gattatgaag agtggttcag
    15601 acaattttcg tgcttcctcg attcagggta ttatgaagcg aatcaaggcg aaaggcgtgc
    15661 ctgtaatcgt ttatgagcca gctatgaaag aggacgattt tttccggtcg cgcgtggtac
    15721 gtgatctgga tgcgttcaaa caagaagctg atgttattat ttctaaccgt atgtctgccg
    15781 atctggctga tgtagcagat aaagtttata cgcgcgactt gtttggcaat gattaattat
    15841 tttgtttcat tctaagaaaa ggccctaata aattagggcc ttttcttatg gttttgtaaa
    15901 atcaaacttt atagaagtta cgataccatt ctacaaagtt ctttacccct tctttaactg
    15961 acgtttcagg tttgaatcct attacgtcat acagtgcttt tgtatcagca ctggtttcca
    16021 gtacatcacc gggttggaga ggcatcatat ttttgttggc ttcaataccc agagcctctt
    16081 ctaacgcatt gatatagtcc atcaactcca caggcgaact attaccaatg ttatagacac
    16141 gatatggtgc tgaacttgtt gcaggcgagc ctgtttctac agcccactgt gggttttttt
    16201 ctggaataac atcctgtaag cgaataatag cttcggcaat atcatcaatg taagtaaagt
    16261 cacgcttcat tttgccgaag ttgtaaacat caatgctttt accttccagc atggctttag
    16321 tgaatttaaa taatgccata tccggacgtc cccatggacc ataaaccgta aagaaacgca
    16381 gccctgtggt cggtaagcca tacaaatgag aatatgtatg ggccatgagt tcattcgctt
    16441 ttttagttgc tgcataaagc gaaacaggat gatctacaga gtcatctgta gagaaaggca
    16501 tcttgcggtt catgccataa acagaactgg aggaagcgta aagtagatgc tgaacattat
    16561 tatggcgaca tccttctagt atgttcagga atccaatcag gtttgcatct gcatatgcat
    16621 tgggattttc aagagagtaa cgtacaccgg cttgcgcagc gaggtttatt acgcgttcga
    16681 accgctcgtc tgcaaacagt gccgccattt tctcacgatc ggccaggtca attttataaa
    16741 aactgaagtt gtcgtgcttg agtaaatcaa gtcgtgcttg tttgaggttg acatcgtaat
    16801 aatcatttaa gttgtcaatg cctacaacct gatgaccagc tgcaagaagc cgtttactta
    16861 catagaaacc gataaagcca gcagctcccg taaccagaaa tttcatttat aatcctcgct
    16921 caggctagaa tatagccaat cttcatctgg cataactgaa agttaaatca taccgttaga
    16981 caagaaaaaa agataatcgg tatcagttct aaacttggct gtttattctg gtaacgtgct
    17041 cattttacaa tcaaagctgt tctaagctga ctatacaagc cgacgtcatt atctccaacc
    17101 gtatggcaga agagcttaag gatgtggcag acaaagtcta cacccgcgat ctctttggca
    17161 gtgactaaca tcctgttatc atggcgattt tcgccctgat tctcttatgt tccctttgta
    17221 ataattcatt atttttatca tttatcctat agcattcatg gcgattatcg ctaaactatg
    17281 gcgacttaaa attatttcgt ccgttagggt aatgatgaga gtagaaaata ataatgtttc
    17341 tgggcaaaac catgacccgg aacagattga tttgattgat ttactggtgc agttgtggcg
    17401 tggcaagatg acaattatca tctctgtcat tgttgctatt gccctggcta tagggtatct
    17461 ggccgttgcc aaagaaaagt ggacttccac agctatcgtt actcaacctg atgtggggca
    17521 aatcgctggt tataccaacg cgatgaatgt gatttacgga tcggctgtac cgaaagtctc
    17581 cgacattcag gcttcactta tcggacgtta cagcactgca ttttcagcat tagcggaaac
    17641 gctggataac caggaagaag cagagaagct caccattgag cctaccgtca aaaatcagtc
    17701 attaccttta gcggtgtctt atgttggtga aacacctgaa ggtgcgcaga aacagctggc
    17761 gaagtatatc cagcaagttg acgaccaggt aaatgaagaa ctggaaaaag acctgaaaga
    17821 caacatcgcg ctgcgtatga aaaacttgca ggattctctg aaaactcagg aagtagttgc
    17881 gcaggagcag aaagatctgc gtatccgtca gattcaggaa gcgttgcagt atgcgaatca
    17941 ggcgcaggtg acaaagccac aggttcagca gactgaagat gtgacgcaag atacgttgtt
    18001 ccttttgggg agcgaagcgc tggagtcgat gattaagcat gaggcgactc gtccgttggt
    18061 gttctcatca aactactatc agactcgtca aaacctgctg gatatcgaca atcttgacgt
    18121 tgataaactt gatattcatg cttaccgcta tgtgatgaaa ccgacgttac ctattcgtcg
    18181 cgatagcccg aaaaaggcaa ttaccttgat tctggcggtg ctgctgggcg gcatggttgg
    18241 cgcggggatt gtcttggggc gtaacgctct gcgtaattac aacgcgaagt aatcttttcg
    18301 gttttaaaga aaaggggcag ggtggtgaca ccttgcccgt ttttttttcc ggatgctaca
    18361 acaatatcgc atccgcttac cccgcaactc actgatgccg tttacgcagg ttctcaatca
    18421 ccgtcgttaa gtccagatcc tgatcctgca acagcaccag caggtgatac atcaaatcag
    18481 atgcctcgtt ggtcagctca aagcggtcat gtaccgttgc ggcaagtgcg gtttccaccc
    18541 cttcttcgcc cactttctgc gcaatgcgtt tggtgccgct ggcatacagt ttggcggtat
    18601 aggaggtttc cggatcggca gatttacgtt cggcgagcag ttgttccagt tgatacagga
    18661 acagccactg gtgagcggtg tcgccgaagc agctgctggt gcctttgtga caggttggcc
    18721 cgatgggatt cgctagcacc agtaacgtgt cgttgtcgca gtccggcgca atgctcacca
    18781 cattgaggaa attgcccgac gtttcgcctt tggtccacag tcgctgttta gtgcgcgaga
    18841 agaaggtgac tttgccgctt tcgatggtct tgtctaaagc ttccgggttc atatagccca
    18901 gcattaacac ttcaccggat accgcgtgtt gcacaatcac cggcataagt ccgtcggttt
    18961 tttcccagtc cagttcgcga cgttgttgtt ctgttaacat atcctgatct ccacgccctg
    19021 tgttgccagg tacgc
//
