LOCUS       LC177554               22955 bp    DNA     linear   BCT 15-DEC-2018
DEFINITION  Escherichia coli DNA, O-antigen biosynthesis gene cluster OgN17,
            strain: E1647.
ACCESSION   LC177554
VERSION     LC177554.1
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1
  AUTHORS   Iguchi,A., von Mentzer,A., Kikuchi,T. and Thomson,N.R.
  TITLE     An untypeable enterotoxigenic Escherichia coli represents one of
            the dominant types causing human disease
  JOURNAL   Microb Genom 3 (2017) In press
  REMARK    DOI:10.1099/mgen.0.000121
            Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 22955)
  AUTHORS   Iguchi,A., von Mentzer,A. and Thomson,N.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2016) Contact:Atsushi Iguchi University of
            Miyazaki, Faculty of Agriculture; Gakuenkibanadai-nishi 1-1,
            Miyazaki, Miyazaki 889-2192, Japan
FEATURES             Location/Qualifiers
     source          1..22955
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="E1647"
                     /db_xref="taxon:562"
                     /note="Escherichia coli O-antigen biosynthesis gene
                     cluster OgN17"
     gene            14..1408
                     /gene="wcaM"
     CDS             14..1408
                     /gene="wcaM"
                     /codon_start=1
                     /transl_table=11
                     /product="colanic acid biosynthesis protein"
                     /protein_id="BAV90538.1"
                     /translation="MPFKKLSRRTFLTASSALAFLHTPFARALPARQSVNINDYNPHD
                     WIASFKQAFGEGQTVVVPAGLVCDNINTGIFIPAGKTLHILGSLRGNGRGRFVLQDGS
                     QVTGGEGGSMHNITLDVRGSDCTIKGLTMSGFGPVTQIYIGGKNKRVMRNLTIDNLTV
                     SHANYAILRQGFHNQIIGANITNCKFSDLQGDAIEWNVAINDSDILISDHVIERINCT
                     NGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKHFVIRNIK
                     ARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYLSIPQNF
                     RVNNIQLDNTHLVYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFMRNINV
                     MQESSLGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNERGQSSVDIDRINHHIV
                     NVEKINFRLPERRE"
     gene            1571..2476
                     /gene="galF"
     CDS             1571..2476
                     /gene="galF"
                     /note="OgN17_1"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /protein_id="BAV90539.1"
                     /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYI
                     VDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVT
                     IMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNE
                     TGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGR
                     YVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQA
                     FVKYGLRNLKEGAKFRKGIEKLLSE"
     gene            2847..3932
                     /gene="rmlB"
     CDS             2847..3932
                     /gene="rmlB"
                     /note="OgN17_2"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6 dehydratase"
                     /protein_id="BAV90540.1"
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLA
                     DVSDSERYVFEHADICDAAVMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARNYWSALDGDKKNSFRFHHISTDEVYGDLPHPDEVNNTEELPLFTETTA
                     YAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KTLPIYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDL
                     LDEVVPKEKSYREQITYVADRPGHDRRYAIDAEKISRELGWKPQETFESGIRKTVEWY
                     LANAKWVENVKSGAYQSWIEQNYEGRQ"
     gene            3932..4831
                     /gene="rmlD"
     CDS             3932..4831
                     /gene="rmlD"
                     /note="OgN17_3"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="BAV90541.1"
                     /translation="MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPE
                     GVAETVGSIRPDIIVNAAAHTAVDKAESEPEFAQLLNATSVEAIAKAANEVGAWVIHY
                     STDYVFPGTGEIPWQETDATAPLNVYGETKLAGEKALQEHCAKHLIFRTSWVYAGKGN
                     NFAKTMLRLAKEREELSVINDQFGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVAS
                     GTTTWYDYAALVFEEAREAGIPLALNKLNAVPTTAYPTPARRPHNSRLNTVKFQQNFA
                     LVLPDWQVGVKRMLNELFTTTAI"
     gene            4889..5767
                     /gene="rmlA"
     CDS             4889..5767
                     /gene="rmlA"
                     /note="OgN17_4"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="BAV90542.1"
                     /translation="MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTL
                     MLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPTPDGLAQAFIIGEEFIGG
                     DDCALVLGDNIFYGHDLPKLMDVAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISL
                     EEKPLQPKSNYAVTGLYFYDNDVVEMAKNLKPSARGELEITDINRIYMEQGRLSVAMM
                     GRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAYRKGFIDAEKVKVLAEPL
                     KKNAYGQYLLKMIKGY"
     gene            5772..6320
                     /gene="rmlC"
     CDS             5772..6320
                     /gene="rmlC"
                     /note="OgN17_5"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="BAV90543.1"
                     /translation="MNVIKTDIPDVLIFEPKVFGDERGFFMESFNQKVFEEAVGRKVE
                     FVQDNHSKSTKGVLRGLHYQLEPYAQGKLVRCVVGEVFDVAVDIRKSSPTFGKWVGVN
                     LSAENKRQLWIPEGFAHGFLVLSETAEFVYKTTNYYHPESDRGIRWNDHQLCISWPTV
                     DEYQLSPKDTRQPFFFDIELFH"
     CDS             6332..7210
                     /note="OgN17_6"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf7"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90544.1"
                     /translation="MLVSIAMTTYNGALYVKQQLRSLVSQTYKNIEIVIVDDCSTDST
                     IEIIEEFADERIILIKNDSNIGCTLSFQKAIELCRGDYIALCDQDDVWMLNKIEILLK
                     EIGEHSLAYSNYSLIDKEGNSIKNFNRYVNKLHGMDSSFENFELYALFNSFILGCSIM
                     FDKAIVKNILPIFDNGSNHDKWIVFQAALENGVKYVNKELFMYRIHGTNYSFQKRKVK
                     RNNIMIYFPYDVLLQYKLNEKLNDKYNTILNIVKNFDEKRLSKIKAVIKYYRFIGARY
                     NYFTKIKQLIKFVVVS"
     gene            7217..8464
                     /gene="wzx"
     CDS             7217..8464
                     /gene="wzx"
                     /note="OgN17_7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="BAV90545.1"
                     /translation="MEMIKSTLMRNILFLGLIQGSSFLLPLILLPFLIKTLGTETYGK
                     MILYQVFFLYLSTIIDFGYNFSATQNIARNQNDSYHIKKVFSCTIWCKIFIFIIVFIF
                     LLGCGLWTKKNYDILLVICFIPQLIGYVLTPQWLFQGIEKTNILAICTITARLFTTLI
                     ILITVHKSTDIYLAAFLQSVTFLLTAILSLYYIYSTKIASFSYVCMKDIKDSLIESFP
                     FFISIFSVNLYTTLPALVIGVVLGNVNLAYYNIALTIRNALLGLFNPISQSLFPRVNN
                     LYSIDQNRAYKLIKQSLIVVAVIFIFLAITTNIMSDFIVNKILGHSEFIVVSLVKMIC
                     FIPAISAINNILGIQTIILHGYKKLFSTVTIFYGVLNCIIIYPSLIYFGVIGAIYSSI
                     FIELLIFITLALIVLQKKLLVAA"
     CDS             8732..9808
                     /note="ISEc1 family; OgN17_8"
                     /codon_start=1
                     /transl_table=11
                     /gene="IS"
                     /product="transposase"
                     /protein_id="BAV90546.1"
                     /translation="MKHKLSDILVLTIFAVISDAEGWENVEDFGETHLDFLKQFCVFA
                     NGIPVHDTIARVVSCISPAKFHECFIHWIMRDCFSSDGKDDIAIDGTTLRHSYGKSRR
                     KGAIHVISAFSTMHSLVIGRIKTDDKSNEITAPPELLNILDIKGKIITTDAMGCQKDI
                     AEKIQKQGGDYLFAVKGNQGRLNKAFEEKFLLKELNNPEHDSYAISEKSHGREEIRLP
                     IVCDVPDEIIDFTFEWKGLKKLCVAASFRSIIAEQKKEPEMTVRYYISSPDLTAEKFA
                     TAIRNHWHVENKLHWRLDVVMNEDDCKIRRGNAAELFSGIRHIAINILTNDKVFKAGL
                     RRKMRKAAMDRNYLALVLAGSGLS"
     CDS             9894..10724
                     /note="OgN17_9"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf10"
                     /product="hypothetical protein"
                     /protein_id="BAV90547.1"
                     /translation="MIKSVMKIKVIIAIYYPQYLKKVKEEISRIFAGKDYQVLFVSNN
                     DKCNINENENSNSFWIKGSNCAGEFSAWDEGYAFLKDKELLSENDIVVFMNDTFCHHR
                     LFTFYDRVLYRKAILSCSDINILGEVNAIGDIFYINNFPLSSWISSYIFFGKKNNIDK
                     LLPFNKTNTLDNKDILHIESELKNNKVDVPFFSRELNEHLTKWLFPSNASGWYKANKT
                     SSAILFFKLKAIVNEKLLAYNILSKDILIEDIYEGQMNRIYNSIRYRVYHLCKKYKLL
                     "
     gene            10738..12054
                     /gene="wzy"
     CDS             10738..12054
                     /gene="wzy"
                     /note="OgN17_10"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="BAV90548.1"
                     /translation="MNAIIHDKSNIIHKHSVFASLCILFILLAMCINDLPVQLYGGTL
                     AASPIWILSVILLIITLLRNNYYLHLDPYSYLFLNFFILSFTISFIQCVYYYLAEGVY
                     INNYGVSIIGKLFFASSYYFVFFLVVYCSNYLLCFVSKKTFINILTGVSFFLFLIMVI
                     EYIDPSLLSVFHLTMDGYGVGARLRLLSPEPSIAAFTFNLFIMITLTFSKNIFLRIFY
                     VGLLILGNLVIGSKSSLILIVCAGLLVFYLNLSFIQKLKSLILLIPSIVLCGYVTVNT
                     ILPALTIDVEQFSSVSTRLITSIWALLSLLYYPLGEGYGTYTVWFTSPLESAIDFANE
                     FVPFSLNLSEINAMINTGNYLSAKSGILSSVIYSGFIAVMFFFLLFKKSFKDISLSNI
                     VYYQKISLRIVLWYTFLSLLLAVNIEVLYVFLLPFIVVNFVRNFTA"
     CDS             12065..13183
                     /note="OgN17_11"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf12"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90549.1"
                     /translation="MEKILYISLSLEKSNYGGSIVSRSNLKGLKHNTALQIKEIAIVR
                     KIEDIYSYELLADTSKIKTAFNNFRGYAGRLNSRIISEIRNIIIDYKPTIIYLDSSLL
                     GCIAKWCKNEVPQAKVVTFFHNAEYDFEMGRLKTGKLHFLPSLYSSVLAEREAVKYSD
                     IIITLHKNDSERLFELYQRRADFCVPVCIIDEPYLDIIEHDKTIELEKPFTIGFIGTA
                     FYANIQAAEYISQHIATAFNNDTQFIIAGNGFEDYATKLNRPNLKTYGFVESLYDFYE
                     NIDVVISPITIGGGMKVKIAEAFKYNRKVIASSFSLIGYEDSLNNSDVCSCSNLKDYL
                     HAINHLRKSREVKSTTRELYKKYYSEKACASYFKDVFK"
     CDS             13226..14332
                     /note="OgN17_12"
                     /codon_start=1
                     /transl_table=11
                     /gene="orf13"
                     /product="glycosyltranslocase"
                     /protein_id="BAV90550.1"
                     /translation="MRILEVSKLYPPFWGGIETVVYDISTVLKQKDYDVDVLCVSESN
                     HSSREVMDNVNVYRCSSIVHMASTYISFEFIKVWRSIRNNYDVIHVHLPNPLALLAIF
                     LFRPRRGCKIIVHWHSDIIKQKFLKIPFIPLQNSLLSNCDKIIATSQVYANSSLDLKK
                     YLNKVAIIPIGIDDKRMSIDVDRIKKIKNSYPGKLIVFSLGRHVYYKGFDYLIDAAKY
                     LDDNYIIIIGGQGQLTSSLNEKISKYDLSKRVKLIGRINEEDVSSYFYAADIFCLPSI
                     ERSEAYGVVQLEAMACGTPIISTDISGSGVSWVNKHGVTGLVVKNKNPQELAKGIKYL
                     SAHPFEKEHIQKYFMENYTRTKMVDCLIEVIKSA"
     gene            14325..15752
                     /gene="manC"
     CDS             14325..15752
                     /gene="manC"
                     /note="OgN17_13"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="BAV90551.1"
                     /translation="MLKMKILPVIMAGGSGTRLWPLSRYQYPKQFLSLFNEHSLLQAT
                     VLRLNTLECLKPLIISNDEHRFIVAEQLRTSGINSFDVILEPVGRNTAPAIALAALHA
                     QKGGQDPVMLVLAADHVIQNEDEFCKSILIAQEQAAKGNMVTFGVVPSRAETGYGYIR
                     KGERVTESVYKVDAFVEKPDLSTAMFYLSDGHYLWNSGMFMFKASVYLTELQKFCPEI
                     IELCQIALAKGSSDLDFIRLEKKAFSQCPDVSIDYAVMEKTSHSVVVPMDAQWSDIGS
                     WNSLWDISSKDKNGNVTHGDVIYHNSNNNFVYADNALVATIGADNLVIVQTKDAVLIA
                     KQDQVQNIKQVVDVLKREKRTEHLSHREEYRPWGRFDLIDHGSRYQVKRITVKPGERL
                     STQKHYHRAEHWVVVSGTAKVTRGEEVYLISENESTYIPLGVIHSLENPGKIPLEVIE
                     IQSGVYLGGDDIIRLNDKYGRIKGE"
     gene            15749..17182
                     /gene="manB"
     CDS             15749..17182
                     /gene="manB"
                     /note="OgN17_14"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="BAV90552.1"
                     /translation="MIVLNSKYIIEHSNISFGTSGARGLVSDFEPKVCAAFVHSFLDI
                     MARKFKFDTVAVAIDNRPSSYSMAQACVHAIIEKGYKPIFFGVIPTPALAYQSLQEKI
                     PAIMVTGSHIPFDRNGLKFYHPDGEISKEDERQILQHESLFNITLPLPSLSVSQIASK
                     NYIKRYTSLFKENLLAGMRIGIYEHSSAGRDLYAKIFTRLGAEIISIERSNEFVPIDT
                     EAVSKEDKDKARRWVREFNLDAIFSTDGDGDRPLVADEQGEWLRGDILGLLCAKALNI
                     EALAIPVSCNTAVIKCGYFSHVTLTKIGSPYVIAAFESLRKKYHCIAGFEANGGFLLG
                     SDIIYENNNISALPTRDALLPFLMVLAHSKKYNTPISKLLLELPSRYTHSDRIQNFSN
                     VLSNKIIANCHRDPNAFIKSLGLDQDVKKVDSTDGMRITLNDDSILHLRPSGNAPELR
                     CYAESSSLCAAILLVEHTLKKLVDLSA"
     CDS             17745..18134
                     /note="OgN17_15"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="BAV90553.1"
                     /translation="MLLCIVGYIITIIFTLINFHVFGNNQASYGIGMNMAFCAIGLFI
                     LFQSIKESVITRNITKLSKYTHDVYLTHIFMMYYISAYIKIATTNDTFNSLLTVVASF
                     IMALIFPFVIDNVVILRMINKLKLRSI"
     gene            18268..19674
                     /gene="gnd"
     CDS             18268..19674
                     /gene="gnd"
                     /note="OgN17_16"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAV90554.1"
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA
                     ENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGN
                     TFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIA
                     AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQT
                     FTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEP
                     LSLITESVFARYISSLKEQRVAASKVLSGPQAQPAGDKGEFIEKVRRALYLGKIVSYA
                     QGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPY
                     FKQIADDYQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGA
                     HTYKRIDKEGVFHTEWLD"
     gene            19923..21089
                     /gene="ugd"
     CDS             19923..21089
                     /gene="ugd"
                     /note="OgN17_17"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="BAV90555.1"
                     /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISP
                     IVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIK
                     DVVEINPYAVMVIKSTVPVGFTAAIHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
                     GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYA
                     ESLGLNSRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAI
                     VDANRTRKDFIADAILSRKPHVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVII
                     YEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD"
     gene            21199..22212
                     /gene="wzz"
     CDS             21199..22212
                     /gene="wzz"
                     /note="OgN17_18"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen chain length determinant protein"
                     /protein_id="BAV90556.1"
                     /translation="MRTWKFPSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQLWRGKM
                     TIIIFVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSD
                     VQETLIGRFSSAFSALAETLDNQEEPEKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKL
                     AQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLKTQEVVAQEQKDLRIRQIQEALQY
                     ANQAQVAKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDI
                     ENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNY
                     NAK"
     gene            complement(22309..22920)
                     /gene="hisI"
     CDS             complement(22309..22920)
                     /gene="hisI"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="BAV90557.1"
                     /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDK
                     TIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTS
                     SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
                     ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ"
BASE COUNT     6953 a   4096 c   4795 g   7111 t
ORIGIN
        1 tagaggagaa cgtatgccat ttaaaaaact ctcccgacgc accttcctga cggcaagctc
       61 cgcgcttgcc ttcctccata cacctttcgc ccgtgcactt cctgcccgac aaagcgttaa
      121 cattaacgac tacaaccctc acgactggat cgcctcattt aaacaagcct tcggcgaagg
      181 gcaaacggtc gtcgtgcctg ccggattggt ttgcgacaat atcaacaccg gcatcttcat
      241 tcctgcaggt aaaacgttac acatccttgg aagcctgcgc ggcaacggca gagggcgatt
      301 tgtcttacag gacggcagcc aggtgacagg gggggagggc ggcagtatgc ataacatcac
      361 cctggatgtg cgcggctctg actgcaccat caaagggctg actatgagcg gctttggtcc
      421 ggtaacgcag atttatatcg gcggcaaaaa caaacgggtc atgcgcaacc tgaccatcga
      481 taacctgacc gttagccacg ctaattacgc catcttacgc cagggatttc ataaccagat
      541 tatcggtgcc aacatcacca actgtaagtt cagcgactta caaggcgacg ccattgaatg
      601 gaacgtggca attaacgaca gtgatatttt gatctccgac catgtcatcg agcgcatcaa
      661 ctgtactaat ggcaaaatca actggggcat cggcataggc cttgcgggga gtacctacga
      721 taataactac ccggaagacc aggcagtgaa aaactttgtc gtggcgaata tcacgggatc
      781 ggattgtcgg cagttgatcc atgttgaaaa tggcaaacat tttgttattc gtaatatcaa
      841 agctcgcaat atcacgccgg atttcagtaa gaaagcaggc attgataacg cgacagttgc
      901 tatttacggt tgtgacaatt tcgtgattga taatattgaa atgattaata gcgccgggat
      961 gttaatcggc tatggggtaa ttaaaggcaa atatctctcg ataccgcaaa atttccgagt
     1021 gaataatatt caactggata acacccatct tgtttataaa ttgcgcggca tccaaatctc
     1081 cgccgggaat gctgtctcct ttgtggcgct gactaacatt gagatgaagc gtgcgtcgct
     1141 ggagttacac aacaaaccgc aacatctttt tatgcgtaat attaatgtga tgcaggaatc
     1201 ctctcttgga cccgcattga gcatgaactt cgacatgcgc aaagacgttc gcggcgtctt
     1261 tatggcgaaa aaagaaacac tcctgtctct tgcaaatgtt catgcggtga atgaaagagg
     1321 acaaagctcc gtcgatatcg acaggattaa tcaccatatt gttaatgtgg aaaagattaa
     1381 ctttagattg ccagaacgga gggagtagat ttgcgaccat tcctggaaaa atggagccat
     1441 acttaggaac aatgctactg caatccacaa cgaagcggcg taacatcaca agtaattcag
     1501 taatcaattc agggtaattg atgctggcga aaaaaatcga acaagctata attcagcaac
     1561 cattttacag gtggatgaaa taatgacgaa tttaaaagca gttattcctg tagcgggtct
     1621 tgggatgcat atgttgcctg ccactaaggc gattcccaaa gagatgctac cgatcgtcga
     1681 caagccaatg attcagtaca ttgttgacga gattgtggct gcagggatca aagaaatcct
     1741 cctggtaact cacgcgtcca agaacgcggt cgaaaaccac ttcgacacct catatgaatt
     1801 agaatctctc cttgagcagc gcgtgaagcg tcaactgctt gcggaagtgc agtccatctg
     1861 tccaccgggc gtgaccatta tgaacgtgcg tcagggcgaa cctttaggtt taggccactc
     1921 cattttatgt gcacgacccg ccattggtga caacccattt gtcgtggtgc tgccagacgt
     1981 tgtgatcgac gacgccagcg ccgacccgct gcgctacaac cttgctgcca tgattgcgcg
     2041 cttcaacgaa acaggacgca gccaggtgct ggcaaaacgt atgccgggtg acctctctga
     2101 atactccgtc attcagacca aagaaccgct ggatcgcgaa ggcaaagtca gccgcatcgt
     2161 ggaatttatc gaaaaaccgg atcagccgca gacgctggac tcagacatca tggccgtggg
     2221 tcgctatgtg ctttctgccg atatttggcc ggaacttgaa cgcactcagc ctggtgcatg
     2281 ggggcgtatt cagctgactg atgccatcgc tgaactggcg aaaaaacagt ctgttgatgc
     2341 catgctgatg acaggtgaca gctatgactg cggtaaaaaa atgggttata tgcaggcatt
     2401 tgtgaagtat ggactacgca acctgaaaga aggggcgaag ttccgtaaag ggattgagaa
     2461 gctgttaagc gaataatgaa aatctgaccg gatgtaacgg ttgataagaa aattataacg
     2521 gcagtgaaga ttcgtggcga aagtaattgt tgcgaatttt cctgccgttg ttttatataa
     2581 acaatcagaa taacaaagag ttagcaatag gattttcgtc aaagttttcc aggattttcc
     2641 ttgtttccag agcggattgg taagacaatt agcgtttgaa tttttcgggt ttagcgcgag
     2701 tgggtaacgc tcgtcacatc gtaggcatgc atgcagtgct ctggtagctg taaagccagg
     2761 ggcggtagcg tgcattaata cctctattaa tcaaactaag agccgcttat ttcacagcat
     2821 gctctgaagt aatatggaat aaaagagtga agatacttgt tactggtggc gcaggattta
     2881 ttggttctgc tgtagttcgt cacattataa ataatacgca ggatagtgtt gttaatgtcg
     2941 ataaattaac gtacgccgga aacctggaat cacttgctga tgtttctgat tccgaacgct
     3001 atgtttttga acatgcggat atttgcgatg cagctgtaat ggcacggatt tttgctcagc
     3061 atcagccgga tgcagtgatg cacctggcag ctgaaagcca tgttgaccgt tcaattacag
     3121 gccctgcggc atttattgaa accaatattg ttggtactta tgtcctttta gaggccgctc
     3181 gcaattactg gtctgctctt gatggcgaca agaaaaatag cttccgtttt catcatattt
     3241 ctactgacga agtctatggt gatttgcctc atccagatga agtaaataat acagaagaat
     3301 tacccttatt tactgagacg acagcttacg cgccaagcag cccttattcc gcatccaaag
     3361 catccagcga tcatttagtc cgcgcgtgga aacgtaccta tggtttaccg accattgtga
     3421 ctaattgctc taacaattat ggtccttatc atttcccgga aaaattaatt ccattggtta
     3481 ttctcaatgc tctggaaggt aaaacattac ctatttatgg taaaggggat caaattcgcg
     3541 actggttgta tgttgaagat catgcgcgtg cgttatatac cgtcgtaacc gaaggtaaag
     3601 cgggtgaaac ttataacatt ggtggacaca atgaaaagaa aaacatagat gtagtgctca
     3661 ctatttgtga tttgctggat gaggttgtac cgaaagagaa atcttaccgc gagcaaatta
     3721 cttatgttgc cgatcgcccg ggacacgatc gccgttatgc gattgatgca gagaagatta
     3781 gtcgcgaatt gggatggaaa ccacaggaaa cgtttgagag cgggattcgt aaaacagtgg
     3841 aatggtacct tgctaatgca aaatgggtcg aaaatgtgaa aagtggtgcc tatcaatcgt
     3901 ggattgaaca gaactatgag ggccgccagt aatgaatatt ctccttttcg gcaaaacagg
     3961 gcaggtaggt tgggaactac agcgtgctct ggcacctctg ggtaatttga ttgctcttga
     4021 tgttcactcc actgattatt gtggtgattt tagtaatcct gaaggtgtag ctgaaaccgt
     4081 aggaagcatt cggcctgata ttattgtcaa cgcagccgct cacaccgcag tagacaaagc
     4141 agaatcagaa ccggagtttg cacaattact taacgcgaca agtgtcgaag cgattgcgaa
     4201 agcagccaat gaagtcggcg cctgggttat tcactactct actgactacg tatttccggg
     4261 gaccggtgaa ataccatggc aggagacgga tgcaaccgca ccgctaaatg tttatggtga
     4321 aaccaagtta gctggagaaa aagcattaca agagcattgt gcgaagcacc ttattttccg
     4381 taccagctgg gtatatgcag gtaaaggaaa taacttcgcg aaaacgatgt tgcgtctggc
     4441 aaaagagcgt gaagaattat cggttattaa cgatcagttt ggtgcgccaa caggggctga
     4501 gttgctggct gattgtacgg cacatgccat tcgtgttgca ctgaataaac cagaagtcgc
     4561 aggcttgtac catctggtag ccagtggtac cacaacctgg tacgattatg ctgcgctggt
     4621 ttttgaagag gcgcgcgaag caggcattcc ccttgcactc aacaagctca acgcggtacc
     4681 aacaacagct tatcctacac cagctcgtcg tccacataac tctcgtctta atacagtaaa
     4741 atttcagcag aactttgcgc ttgtcttgcc tgactggcag gttggcgtga aacgcatgct
     4801 caacgaatta tttactacta cagcaattta atagtttttg catcttgttc gtgattgtgg
     4861 agcaagatga ataaaaagga atgatgaaat gaaaacgcgt aaaggtatta ttttagcggg
     4921 tggttctggt actcgccttt atcctgtaac tatggctgtc agtaagcagc tgttaccgat
     4981 ttatgataaa ccgatgatct attacccgtt gtctacactg atgttagcgg gtattcgcga
     5041 tattctgatt atcagtacgc cacaggatac tcctcgtttt caacaactgc tgggtgacgg
     5101 tagccagtgg gggctaaatc ttcagtacaa agtgcaaccg actccagatg ggcttgcgca
     5161 ggcgtttatt atcggtgaag agtttatcgg tggtgatgat tgtgctttgg ttcttggtga
     5221 taatatcttc tacggccacg atctgccgaa gttaatggac gtagctgtta acaaagaaag
     5281 tggtgcaaca gtatttgctt atcacgtaaa tgatcctgaa cgctacggtg tcgttgagtt
     5341 tgataaaaac ggtacggcaa tcagtctgga agaaaaaccg ctacaaccaa aaagtaatta
     5401 tgcggtaacc gggctttatt tctatgataa cgacgttgtc gaaatggcga aaaaccttaa
     5461 gccttctgcc cgcggtgaac tggaaattac cgatattaac cgtatctata tggaacaagg
     5521 gcgtttatct gttgctatga tggggcgtgg ttatgcgtgg ttagacacgg ggacacatca
     5581 gagcctgatt gaggcaagca actttattgc aacaattgaa gagcgtcaag ggttgaaagt
     5641 ttcctgcccg gaagaaattg cttaccgtaa agggtttatt gatgctgaga aggtgaaagt
     5701 attagctgaa ccgctgaaaa aaaatgctta tggtcagtat ctgctgaaaa tgattaaagg
     5761 ttattaataa aatgaacgta attaaaacag acattccaga tgtattaatt ttcgagccga
     5821 aagtttttgg tgatgaacgt ggttttttta tggaaagctt taatcagaaa gttttcgaag
     5881 aggctgtagg gcggaaggtt gaatttgttc aggataatca ttctaaatca actaagggtg
     5941 tgttacgcgg actgcactat cagctggaac cttatgctca aggtaaatta gttcgttgtg
     6001 tggtcggtga agtttttgat gtagcagttg atattcgtaa atcgtcacca acttttggca
     6061 aatgggttgg ggtgaattta tctgctgaga ataagcgcca gttgtggatc cctgaaggat
     6121 ttgcacatgg ttttttggtg ctgagtgaga cggctgagtt tgtttataaa actacaaatt
     6181 attatcatcc ggaaagtgac agaggaatta ggtggaatga tcatcaatta tgtatatcat
     6241 ggcccacagt cgatgagtat caactttcac ctaaagatac aagacaacca ttttttttcg
     6301 atattgaatt atttcattaa taggtgaata aatgttagtg tcaattgcta tgactactta
     6361 taatggggcc ttatatgtaa aacaacagtt gagatctttg gtatctcaga catataagaa
     6421 tatagaaatt gttattgttg atgattgttc tactgacagc acaatagaaa ttatcgaaga
     6481 atttgcagat gaaagaataa tattaattaa gaatgatagt aatattggat gtacattgtc
     6541 ttttcaaaaa gctatagaac tgtgccgtgg tgattatata gctctttgtg atcaagatga
     6601 tgtttggatg ttaaataaaa ttgaaattct tttgaaagaa attggtgagc actccttagc
     6661 atacagcaat tattcattaa ttgataaaga aggaaatagc atcaaaaatt tcaatagata
     6721 tgtcaataaa ctacatggaa tggattcttc atttgagaac tttgagcttt atgcattgtt
     6781 taattccttt atattgggat gctcaataat gtttgataaa gctatagtta aaaatattct
     6841 acctatattc gacaatgggt ctaatcatga taaatggatt gtctttcagg cagctcttga
     6901 aaatggtgtg aaatatgtga ataaagaact tttcatgtat cgcattcatg gtactaatta
     6961 ttcattccaa aaacgaaaag tgaagcgtaa taatataatg atttattttc cttatgatgt
     7021 gctgttacaa tataagctta atgagaagct aaatgacaag tataatacta tcttgaatat
     7081 tgttaaaaat tttgatgaaa aaagattaag taaaattaaa gctgtaatca aatactatcg
     7141 atttataggg gccagatata attattttac taaaataaag caattaataa aatttgttgt
     7201 agtgagttga atgtaaatgg aaatgattaa atctacatta atgaggaata tattattttt
     7261 aggactaata caaggtagtt ctttcctgtt acctcttata ttgttgccat ttctaattaa
     7321 aacactaggt actgaaacat atggaaaaat gatattgtat caagtctttt ttttatactt
     7381 aagcacaatt attgattttg gatataattt ttccgcgaca caaaatattg caagaaatca
     7441 aaatgattct tatcatataa agaaagtctt tagctgtaca atttggtgta aaatatttat
     7501 ttttataatt gtttttatat ttttattagg atgtggattg tggacaaaaa aaaattatga
     7561 tatattatta gttatatgtt ttataccaca attgattggc tatgttttaa cccctcaatg
     7621 gctatttcaa ggaatagaaa aaaccaatat acttgcaatt tgtacaataa ctgcacgact
     7681 attcaccact ttaattatct tgataacagt tcataaaagt acagatatat acttggccgc
     7741 atttttgcaa agtgtgactt ttttattgac tgcgatattg tctctgtatt acatctactc
     7801 aacaaagatt gcctcatttt cttatgtgtg tatgaaagat ataaaagatt ctttaataga
     7861 aagttttcca ttttttatat ccatattctc tgtaaatctt tacacaacat taccggcctt
     7921 ggttattgga gtagtattag gaaatgtgaa tctagcatat tataatatag ccttaactat
     7981 aagaaatgca ttattaggat tatttaatcc aatttctcaa tcacttttcc cacgagtcaa
     8041 caatttatat tccattgacc aaaatagagc atataaatta ataaagcaat ctttaatagt
     8101 tgtcgcggta atatttattt ttttagcgat aacgacaaat atcatgtcag attttattgt
     8161 caataaaatc ttaggtcatt cagaatttat cgtagtttct ttagtaaaaa tgatatgttt
     8221 tataccggca atttcagcaa ttaacaatat cttaggtata caaacaatta ttttgcatgg
     8281 ctacaaaaaa ttattcagta ctgtaactat cttttatgga gtacttaatt gtataataat
     8341 atatccatca ctaatttatt ttggtgtaat aggagcgatt tattcttcta tttttattga
     8401 actattaata tttataacat tagcattaat agttttacaa aaaaagctat tagtagcggc
     8461 gtgaatttta ttttcgagtt attaatacct tcaggggaag aacatcggaa gtacactact
     8521 tgtaccaggg aaagatcttc ataagtacac ttttcgtact aagcaattcg catttcatgt
     8581 tcataattga gatattcctt atgacctaaa gctgtttttt attgcttata cataatcaaa
     8641 tactccttac ataattaagg agtacaaaat ggaacttaaa aaattgatgg aacatatttc
     8701 tggcatccct aattacagac aagcctagaa tgtgaaacat aaattgtcgg atattctagt
     8761 gttgactatt tttgctgtca tttctgatgc agaaggttgg gaaaatgtag aggattttgg
     8821 ggaaacacat ctcgattttt tgaagcaatt ttgtgttttt gcaaatggta ttcctgttca
     8881 cgataccatt gccagagttg tatcctgtat tagtcctgca aaatttcacg agtgctttat
     8941 tcactggata atgcgtgact gcttttcttc agatggtaaa gacgacatcg ctattgatgg
     9001 aacaactctc cggcattctt atggcaagag tcgccgcaag ggagcgattc atgtcataag
     9061 tgcgttctca acaatgcaca gtctggtcat cggacggatc aagacggatg ataaatctaa
     9121 tgagattaca gctccccctg aacttcttaa catactggat attaaaggaa aaatcatcac
     9181 aactgatgcg atgggttgcc agaaagatat tgcagagaag atacaaaaac agggaggtga
     9241 ttatttattc gcggtaaaag gaaaccaggg gcggctaaat aaagcctttg aggaaaaatt
     9301 tctgctgaaa gaattaaata atccagagca tgacagttac gcaattagtg aaaagagtca
     9361 cggcagagaa gaaatccgtc ttcctattgt ttgcgatgtc cctgatgaaa ttattgattt
     9421 cacgtttgaa tggaaagggc tgaagaaatt atgcgtggca gcctcctttc ggtcaataat
     9481 agcagaacaa aagaaagagc cagaaatgac ggtcagatat tatatcagtt ctcctgattt
     9541 aaccgcagag aagttcgcca ctgcaatccg aaaccactgg cacgtggaga ataagctgca
     9601 ctggcgtctg gacgtggtaa tgaatgaaga cgactgcaaa ataagaagag gaaatgcagc
     9661 agaattattt tcagggatac ggcacatcgc tattaatatt ttgacgaatg ataaggtatt
     9721 caaggcaggg ttaagacgta agatgcgaaa agcagccatg gacagaaact atctggcgtt
     9781 agtccttgcg gggagcgggc tctcgtaatc ttgccctgcg ggaagcagac tttcgtaata
     9841 ttttccctaa tatgtattgt ttatttcaaa tctaaacctt aaaagatctt aatatgataa
     9901 agagtgttat gaaaattaaa gtaattattg caatttatta tcctcaatat ttaaaaaaag
     9961 taaaagaaga aataagccga atattcgcag gtaaagatta tcaggtttta ttcgtaagta
    10021 acaatgataa gtgtaatata aatgaaaatg aaaatagtaa ttcattttgg ataaaaggga
    10081 gtaactgcgc tggggagttt tctgcatggg acgaaggtta tgctttttta aaagacaaag
    10141 aactattatc agaaaatgat attgtagtat ttatgaatga tactttttgc catcatcgtt
    10201 tatttacttt ttatgaccga gtattatata ggaaggcaat attatcttgt tcagatataa
    10261 acatactagg ggaagtaaat gctattggtg atatttttta tataaataat tttcctcttt
    10321 cgtcatggat atcatcttat atattttttg gtaaaaaaaa taatatcgat aaacttcttc
    10381 catttaataa aacaaacact ttagacaaca aggatattct acatatagaa agtgaattga
    10441 aaaataacaa ggtagatgtt cctttttttt ctagagaact taatgagcat ttaactaaat
    10501 ggttgtttcc atcaaatgct agtggttggt ataaagcaaa taaaacgtct tcggcaatat
    10561 tattttttaa acttaaagca attgtaaatg aaaaattact tgcttataac attttgtcta
    10621 aagatatctt gattgaagat atatatgaag gacagatgaa taggatttat aattctattc
    10681 ggtatagagt ctaccatctt tgtaaaaaat ataaactact ataagtgtaa aaaattcatg
    10741 aacgcaataa tacatgacaa gtctaatatt attcataagc attctgtctt tgcatcttta
    10801 tgtattctat ttatcttgtt agctatgtgc attaatgatc ttcctgtaca gttatatgga
    10861 ggaacgttag cagcgagtcc aatatggatc ttatcagtta tacttttgat tattacatta
    10921 ttgagaaata attattattt acatttggat ccttatagct atctattttt aaattttttt
    10981 atcctttcat tcactatctc atttattcaa tgtgtatact attatcttgc ggaaggagta
    11041 tatataaata attatggtgt ttctattatc ggaaagcttt tttttgcatc gtcatactat
    11101 tttgtctttt ttcttgttgt ttattgttct aattatttat tgtgctttgt ttccaaaaaa
    11161 acatttataa atatattaac aggagtctct ttctttctct ttttgataat ggttatagaa
    11221 tatattgatc caagtttgtt atcggtattt catttaacta tggatggata tggagttggt
    11281 gccagattgc ggctactttc tcctgaacca tcaatagctg catttacgtt taatctcttc
    11341 ataatgataa cacttacttt tagtaagaat atctttttaa gaatatttta tgtcggttta
    11401 ttgattttag gtaacctagt gatagggtct aaatcctcac tcatactaat tgtttgtgcg
    11461 ggattacttg tgttctattt aaatctatca tttattcaga agttaaaatc tctaatttta
    11521 ctaataccat caattgtatt atgcggttat gtaacggtta atactatact tcctgctctg
    11581 actatcgatg ttgagcaatt ttccagtgtt agcacgcgtt tgataacttc tatatgggca
    11641 cttcttagtc tactttatta tcctttgggt gaaggttatg gcacttatac agtttggttt
    11701 acttcacctc ttgagagtgc aattgatttt gcgaatgaat ttgttccatt ttcacttaat
    11761 ctttctgaaa ttaatgctat gattaataca ggaaattatc tttctgcaaa atcaggaatt
    11821 ttatcatcag ttatctatag cggatttata gcagtaatgt tttttttcct ccttttcaaa
    11881 aaatctttta aggatataag tcttagtaat attgtttact atcagaaaat aagcttacgg
    11941 atagttttat ggtacacttt cttgtcacta ctattagctg taaatattga agtgttatat
    12001 gtttttctac tgccatttat agttgtgaat tttgtaagaa attttacggc atgaagtaat
    12061 aattatggaa aaaatactat atatatcatt gtctttagaa aaatcaaatt atggtggaag
    12121 tatcgtttca cgatcaaatc taaaaggatt aaaacataat acagctttgc aaattaagga
    12181 gattgcaatt gtaaggaaaa tagaagacat ctattcttat gaattattgg cagacacatc
    12241 aaaaattaaa acagcgttta ataatttccg tggctatgct ggtagactta attcaagaat
    12301 aatttctgag ataaggaata ttatcattga ttataaacct acaataatat atcttgattc
    12361 gagtttgctg ggttgtattg ctaaatggtg taagaatgaa gttcctcaag caaaagttgt
    12421 aacttttttt cataatgctg aatatgattt tgaaatgggg cgtttgaaaa ctggtaaatt
    12481 acattttctt ccgtccttat attcttctgt attagctgag cgggaagctg taaaatatag
    12541 tgatataata atcacattac ataaaaatga ctcggagagg ctttttgaat tatatcaacg
    12601 aagagctgac ttttgtgtgc ctgtttgcat tattgatgaa ccgtatcttg atataattga
    12661 gcatgataaa accatcgagc tagagaaacc gttcactatc ggttttattg gtactgcatt
    12721 ttatgccaat attcaggcgg ctgaatatat ttctcaacat atagcgactg catttaataa
    12781 tgatacacag tttataatcg ctggaaatgg atttgaggac tatgcgacta agcttaatag
    12841 accgaacctt aaaacttatg gttttgtcga gtctctatat gatttctacg aaaatattga
    12901 tgtggttatt tctcctatta ctattggcgg cgggatgaaa gtaaaaatag cagaagcttt
    12961 caaatataat cgaaaagtca ttgcgtcatc attctctttg atcggatatg aagattcatt
    13021 aaataattca gatgtctgtt cctgctctaa tttaaaagac tatttgcatg caatcaacca
    13081 tttaagaaaa tcacgcgaag ttaaatctac tacaagagaa ttatataaaa aatattactc
    13141 tgaaaaagca tgtgcaagtt attttaaaga cgttttcaag taatagacta actatatatt
    13201 aaatatgttc taagcagagg tatgtgtgcg tatacttgaa gtaagtaaat tgtatcctcc
    13261 attctggggg ggaattgaga ctgtggtgta tgatatatca acagtattga agcaaaaaga
    13321 ttatgatgtt gatgttctgt gtgtctctga aagtaatcat tcctctaggg aagtaatgga
    13381 taatgtaaat gtttatcgtt gttcaagtat tgttcatatg gcgagtactt atatttcttt
    13441 tgagtttata aaggtctggc gcagtattag aaataattat gatgtgatac atgttcactt
    13501 acctaatcct cttgcgctgc tagcgatatt tttatttaga ccacggagag gatgcaaaat
    13561 tatcgttcat tggcatagtg atattatcaa acaaaaattc ttaaagattc cttttattcc
    13621 tttacaaaat agtctgttaa gtaactgcga taaaataatt gcaaccagtc aggtgtatgc
    13681 taattcatct ctcgacctaa aaaaatatct taataaagtt gcaataattc ctattggaat
    13741 agatgataaa agaatgtcaa tagatgttga tagaataaaa aaaattaaaa atagctatcc
    13801 cggtaaatta attgtattct ctttgggacg ccatgtgtat tacaagggct ttgattatct
    13861 tatagacgct gcaaaatacc tagatgataa ctatattatt ataataggtg gacaaggcca
    13921 attaacatca tcattaaatg aaaagatcag taaatatgat ctgagtaaac gagttaaact
    13981 aattggtaga ataaatgaag aagatgtttc ctcttatttt tatgctgctg atattttttg
    14041 tcttccttct attgaacgct ccgaagcata cggcgttgta cagttggaag ctatggcatg
    14101 tggtactcca attatctcca cagatatcag tgggtctggt gtgtcttggg tcaataaaca
    14161 tggtgttaca ggattggtcg ttaaaaataa aaacccacaa gagttagcga aaggaattaa
    14221 atatttatca gcacatccat ttgaaaaaga acatattcaa aaatatttta tggaaaacta
    14281 tactagaaca aagatggttg attgtttaat cgaagttata aagagtgctt aaaatgaaaa
    14341 tattacctgt tattatggct ggtggctcag gaactcgctt atggccgtta tctcgatacc
    14401 aatatccaaa gcaattttta tcactattta atgagcattc actgttacaa gcaaccgtac
    14461 tacgcctaaa tacacttgag tgcctaaaac ctctaataat cagtaatgat gagcatcgtt
    14521 ttattgttgc cgagcagtta cgtacgtcag gaattaattc ttttgatgta atacttgaac
    14581 ctgtaggtcg taataccgct ccagcaatag cacttgctgc attacatgct caaaaaggtg
    14641 gtcaggatcc tgtaatgctg gttcttgctg ctgaccatgt aatacagaat gaggatgaat
    14701 tctgtaaaag catattaatt gcacaagagc aagctgcaaa gggaaatatg gtcacctttg
    14761 gtgttgtacc atctcgagca gaaaccggtt atggctatat ccgcaaggga gaaagggtaa
    14821 ctgaatctgt atataaagtt gatgcattcg tagaaaaacc tgatctctcc actgcgatgt
    14881 tttatttgag tgatggacac tatttatgga atagtggtat gtttatgttc aaagctagtg
    14941 tttatctaac tgagttgcaa aaattttgtc cagaaataat tgaattatgc caaatagcat
    15001 tggcaaaagg gtcatccgac cttgacttta tacgccttga aaagaaagct tttagtcagt
    15061 gcccagatgt atcgatagat tatgcggtaa tggaaaaaac atctcatagt gtagttgtgc
    15121 cgatggatgc gcaatggagt gacataggat cttggaattc attatgggat atttctagta
    15181 aagataaaaa tggtaacgtt acgcatggtg atgttatcta ccataatagc aataataatt
    15241 ttgtttatgc agataatgcg ttagtagcaa ctattggtgc agataatctt gttatagtgc
    15301 aaacaaaaga tgcagtgtta atagctaagc aggatcaagt ccaaaatatt aagcaagttg
    15361 tcgatgttct taaaagagag aaacgtactg aacatctctc tcatcgagaa gaatatagac
    15421 cttggggacg cttcgatttg attgatcacg gttcacgtta ccaagtgaaa cgaattacag
    15481 tcaaaccagg ggaacgcctt tcaacacaga agcattatca tcgtgcagaa cattgggtgg
    15541 tagtatcagg tactgcaaaa gttactcggg gagaggaggt ttatttaatc tctgaaaacg
    15601 agtcaacata tataccatta ggtgttattc attcccttga aaatccaggg aaaatacctc
    15661 tggaagtaat tgagattcag tccggggttt atcttggtgg cgatgatata atacgtttga
    15721 atgataagta tggacgaatt aaaggagaat gatagtgtta aactccaaat atataattga
    15781 gcatagtaat atttcctttg gaacaagtgg cgccagaggg ctggtttcag attttgaacc
    15841 taaagtatgt gctgcttttg tgcattcttt tttagatatt atggccagaa aatttaaatt
    15901 tgatactgtc gctgtagcta ttgataatag accaagcagt tactcaatgg ctcaagcctg
    15961 tgttcatgca ataattgaaa aaggttataa acctatattc tttggtgtaa taccaacacc
    16021 agcattggca taccagtctt tgcaggagaa aattccagca attatggtga caggaagcca
    16081 tattccgttt gatcgaaatg gtcttaagtt ttatcatcca gatggggaga tttctaagga
    16141 agatgaacgt cagattctgc agcatgagtc attatttaat ataactttac cactaccatc
    16201 tttatccgta tctcaaattg cttctaaaaa ttatattaaa cgttacacat cgctttttaa
    16261 agaaaattta ttagcaggta tgcgaatagg tatttatgag cattcaagtg ctggtcgtga
    16321 tctctatgct aagattttta ctcgattagg tgctgagatt attagcattg aacgtagtaa
    16381 tgaatttgtg cctattgata ctgaggctgt atctaaagaa gataaagata aagcacgtag
    16441 atgggttcga gaatttaatc ttgatgcaat tttctccact gatggtgatg gtgaccgtcc
    16501 attagttgct gatgaacagg gagaatggct acgtggtgat attttaggtt tactctgtgc
    16561 aaaggcttta aacatagagg cgctagccat tccagttagt tgtaatactg ctgttattaa
    16621 atgtggttat ttctcccatg tcactcttac taaaattggc tctccgtacg taattgctgc
    16681 tttcgaaagc ttgaggaaaa aataccactg tatcgcagga ttcgaggcta atggtggttt
    16741 tttactggga agcgatataa tttatgagaa taataatatt tcagctttgc ctactagaga
    16801 tgctttgtta ccattcctga tggtgttagc tcactcaaaa aaatataata ctcctatctc
    16861 aaaactgtta cttgaactgc catcgagata tactcattca gatcgtatac agaatttttc
    16921 taatgtttta agtaataaga tcattgctaa ttgtcatcgt gatcctaatg cttttatcaa
    16981 gtcattaggc cttgatcaag atgttaaaaa ggtagatagt accgatggaa tgcgcattac
    17041 cttgaatgat gattctattc tgcatttacg cccgtcaggc aatgcaccag agttacggtg
    17101 ttatgctgaa agcagtagtc tatgcgcagc aattctatta gtagagcata cccttaagaa
    17161 acttgtggat ttatcagcat aatcatcatt gttcttataa atgtgtagca ggtaactgat
    17221 ttagttgcct gctaaatttc ttagataggt gcgctcaatt aatatgaaaa ccaagagtat
    17281 acatggcatt gaattgttac gtcttttcgc tatttttatg gttgttttta ttcactcgac
    17341 tcgtgaatat gaaagagtgg tagaggaaaa tattgcttct ttaattttat gatctatatc
    17401 tcaagcaggt tttatctgtt ttttattata atttgatatt ttgctcttaa tcaaaaaaat
    17461 tataatataa aaatattatt ataatagatt tatagtcatt gttattcctt ttttatttat
    17521 gctttttctc cttttttagc ttatttaatt caacgtattg atttaaagat gcgcatggga
    17581 ctattatagt tttactagga atgagttagt attgtattaa tattatttgt tatttccatt
    17641 atgatgatat aatatctacg ccatctatat tcaactgctg cctgtttatt tctaataggc
    17701 tgatttttta tgggattatt tttgataagt ataataagtc agcgttgtta ttatgtattg
    17761 taggttatat aataactatt atctttacgc taataaattt tcatgtgttt gggaataatc
    17821 aagcatctta tggtataggt atgaatatgg ccttttgtgc tataggatta tttatacttt
    17881 ttcaatctat aaaagagtcg gtaatcacgc gcaatattac aaagttatca aaatacactc
    17941 atgatgtata tttaactcat atttttatga tgtattacat aagtgcttat ataaagattg
    18001 cgacaaccaa tgatactttc aattcactgt taacagtcgt tgcatctttt ataatggcgc
    18061 ttatatttcc ttttgtgata gataatgttg tgatattaag gatgattaat aaattaaaat
    18121 taaggagtat atgaaattta taaatcacat tgacggcttt tatctttatt cacaagatta
    18181 gaatcgtttt aatgtccgcg ttaagcttac gagtataaac tatacagcct ttaatataaa
    18241 cttggcaacc cctgacagga gtaaacaatg tcaaagcaac agatcggcgt agtcggtatg
    18301 gcagtgatgg ggcgcaacct tgcgctcaac atcgaaagcc gtggttatac cgtctctatt
    18361 ttcaaccgtt cccgtgaaaa gacggaagaa gtgattgccg aaaatccagg caagaaactg
    18421 gttccttact atacggtgaa agagtttgtt gaatctctgg aaacgcctcg tcgcatcctg
    18481 ttaatggtga aagcaggtgc aggcacggat gctgctattg attccctcaa accatatctc
    18541 gataaaggcg acatcatcat cgatggtggt aacaccttct tccaggacac cattcgtcgt
    18601 aaccgtgagc tttctgccga aggctttaac ttcatcggta ccggtgtttc cggcggagaa
    18661 gagggggcgt tgaaaggtcc ttccattatg cctggtgggc agaaagaagc ctatgaactt
    18721 gttgcgccga tcctgaccaa aatcgccgcc gttgctgaag atggcgaacc gtgcgttacc
    18781 tatattggtg ccgatggcgc gggtcactat gtgaagatgg ttcacaacgg tattgaatac
    18841 ggtgatatgc aactgattgc tgaagcctat tctctcctga aaggcggcct gaatctttct
    18901 aacgaagaac tggcacagac ctttaccgag tggaataacg gtgaactgag cagctacctg
    18961 atcgacatca ccaaagacat cttcactaaa aaagatgaag acggtaacta cctggttgat
    19021 gtgatcctgg atgaagcggc taacaaaggt accggtaaat ggaccagcca gagcgcgctg
    19081 gatctcggcg aaccgctgtc gctgattacc gagtctgtgt ttgcacgtta tatctcttct
    19141 ctgaaagagc agcgtgttgc cgcatctaaa gttctctctg gcccgcaagc gcagccagct
    19201 ggcgacaaag gtgagttcat cgagaaagtt cgtcgtgcgc tgtatctggg taaaatcgtt
    19261 tcttacgctc agggcttctc tcagctgcgt gcggcgtctg aagagtacaa ctgggatctg
    19321 aactacggcg aaatcgcgaa gattttccgt gctggctgca tcatccgtgc gcagttcctg
    19381 cagaaaatca ccgatgcata tgccgaaaat ccgcagatcg ctaacctgct gctggccccg
    19441 tacttcaagc aaattgccga tgactaccag caggcgctgc gcgatgtcgt tgcttatgca
    19501 gtacagaacg gtatcccggt tccgaccttc gccgctgcgg ttgcctatta cgatagctac
    19561 cgtgccgctg ttctgcctgc gaacctgatc caggcacagc gtgactattt cggtgcacat
    19621 acttataagc gcattgataa agaaggtgtg ttccatactg aatggctgga ttaatctgat
    19681 ttaaccaaca ataaaattca ggcccggcgt atattacacc gggctttttt ttgccattta
    19741 tcttatagac taaatttcac tgcttaatat taacttaata aatatcagct attcttataa
    19801 agaaaatctg aattgttttt cgttgcgttg accatctgac aacgtagcgt taaaactttt
    19861 agctcttatc aggatgctaa aaacatcatg attcacagtt aagttaattc tgagagcatg
    19921 aaatgaaaat taccatttcc ggtaccggct atgtaggctt gtcaaacggg cttctaatcg
    19981 cacaaaatca tgaggttgtg gcattagata ttttaccgtc acgcgttgct atgctgaatg
    20041 atcggatatc tccaattgtt gataaggaaa ttcagcagtt tttgcaatca gataaaatac
    20101 actttaatgc cacattagat aaaaatgaag cctaccggga tgctgattat gtcatcatcg
    20161 ccactccaac cgactatgat cctaaaacta attatttcaa tacatccagt gtagaatcag
    20221 taattaaaga cgtagttgag ataaatcctt atgcggttat ggtcatcaaa tcaacggttc
    20281 ccgttggttt taccgcagcg atccataaga aatatcgtac tgaaaatatt attttctctc
    20341 cggaattcct ccgcgaaggt aaagcccttt acgataatct ccatccttca cgtattgtca
    20401 tcggtgagcg ttcagaacgc gcagaacgtt ttgctgctct gttacaggaa ggcgctatta
    20461 agcaaaatat cccgaccctg tttaccgact caaccgaagc agaagcgatt aaactgtttg
    20521 caaacaccta cctggcgatg cgcgtggcgt actttaacga actggatagc tacgcagaaa
    20581 gtttaggtct gaattcccgt caaataatcg aaggcgtttg tctcgaccca cgtattggca
    20641 accattacaa caatccgtcg tttggttatg gtggttattg tttgccgaaa gataccaagc
    20701 agttactggc gaactatcag tctgtgccga ataacctgat ctcggcaatt gtcgatgcaa
    20761 accgcacgcg taaagatttt attgccgatg ccattttgtc acgcaaaccg catgtggtag
    20821 gtatttatcg cctgattatg aagagcggtt cagataactt ccgtgcgtct tctattcagg
    20881 ggattatgaa gcgtatcaag gcgaaaggtg ttgaagtaat catctacgag ccagtgatga
    20941 aagaagactc attcttcaac tctcgcctgg aacgtgatct cgccaccttc aaacaacaag
    21001 ccgacgtcat tatctccaac cgtatggcag aagagcttag ggatgtggca gataaggtct
    21061 acacccgcga tctctttggc agcgactaac atcttgttat cagggctatt tacgccctga
    21121 ttgtcttttg ttacttacgc aacaattcat tatttttatc acttatccta tagcattcac
    21181 gaggattatc gctaaactat gcggacttgg aaatttccgt cagttagggt aatgatgaga
    21241 gtagaaaata ataatgtttc tgggcaaaac catgacccgg aacagattga tttgattgat
    21301 ttactagtgc agttgtggcg tggcaagatg acaatcatca ttttcgtcat tgtggctatt
    21361 gccctggcta ttggatattt ggcagtagcg aaggagaaat ggacgtcaac agcaattatc
    21421 actcagcccg acgtggggca aattgctggc tataacaatg ccatgaatgt tatctatggt
    21481 caggctgcac cgaaagtatc ggatgtgcag gagacgttaa ttggtcgctt cagttctgcc
    21541 ttctctgcat tagcagaaac gctggataat caggaagagc cagagaaact taccatcgaa
    21601 ccttctgtta agaaccagca attaccattg actgtttctt atgttgggca aacagcagag
    21661 ggcgcacaaa tgaagttggc ccaatacatt cagcaagttg acgataaagt caatcaagag
    21721 ctagaaaagg atctcaagga caacattgct ctgggacgga aaaacttgca ggattctctg
    21781 aagacccagg aagtggttgc gcaggagcag aaagatctgc gtatccgtca gattcaggaa
    21841 gcgttgcagt atgcgaatca ggcgcaggtg gcaaagccac aggttcagca gactgaagat
    21901 gtgacgcaag atacgttgtt ccttttgggg agcgaagctc tggagtcgat gattaagcat
    21961 gaggcgactc gtccgttagt gttctcacca aactactatc agacacgtca aaacctgctg
    22021 gatatcgaaa acttaaaggt tgatgatctt gatattcatg cttaccgtta tgtgatgaaa
    22081 ccgacgttac ctattcgtcg cgatagcccg aaaaaggcaa ttaccttgat tctggcggtg
    22141 ctgctgggcg gcatggttgg cgcggggatt gtgttggggc gtaacgctct gcgtaattac
    22201 aacgcgaagt aatctttgca gttttaaaga aaaagggcag ggtggtgaca ccttgcccgt
    22261 tttttttgcc ggatgcgaca acaatatcgc atccgcttac cccacaactc actgatgccg
    22321 tttacgcagg ttctcaatca ccgtcgttaa atccagatcc tgatcctgca acaataccag
    22381 caggtgatac atcaaatcag atgcctcgtt ggtcagctca aagcggtcat gtaccgtcgc
    22441 tgccagtgcg gtttccacgc cttcttcgcc cactttctgc gcaatgcgtt tggtgccgct
    22501 ggcatacagt ttggcggtat aggaggtttc cgggtctgca gatttacgtt cggcgagcag
    22561 ttgttccagt tgatacagga acagccactg atgagcggtg tcgccgaagc agctgctggt
    22621 gcctttgtgg caggttggcc cgatgggatt cgccagcacc agtaacgtgt cgttgtcgca
    22681 gtccggcgca atactcacca cattgaggaa attgcccgac gtttcgcctt tggtccacag
    22741 tcgctgttta gtgcgcgaga agaaggtgac tttgccgctt tcgatggttt tgtctaaggc
    22801 ttccgggttc atatagccca gcattaacac ttcgccggat acagcgtgtt gcacaatcac
    22861 cggcatcagt ccgtcggttt tttcccagtc cagttcgcga cgttgttgtt ctgttaacat
    22921 atcctgatct ccacgccctg tgttgccagg tacgc
//
