LOCUS       AJ576117                9230 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Neisseria meningitidis capsule synthesis genes (cap29eABCDEFGH) and
            ctrA and galE genes.
ACCESSION   AJ576117
VERSION     AJ576117.1
KEYWORDS    cap293H gene; cap29eA gene; cap29eB gene; cap29eC gene; cap29eD
            gene; cap29eE gene; cap29eF gene; cap29eG gene; capsule transport;
            CMP-KDO synthetase; ctrA gene; D-arabinose-5-phosphate isomerase;
            galE gene; glycosyl transferase; KDO 8-phosphate phosphatase; KDO
            8-phosphate synthase; UDP-glucose 4-epimerase.
SOURCE      Neisseria meningitidis
  ORGANISM  Neisseria meningitidis
            Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
            Neisseriaceae; Neisseria.
REFERENCE   1
  AUTHORS   Claus,H. and Vogel,U.
  TITLE     Identification and characterisation of the capsule synthesis genes
            of serogroup 29E meningococci
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9230)
  AUTHORS   Claus,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUL-2003) Claus H., University of Wuerzburg,
            Institute for Hygiene und Microbiology, Josef-Schneider-Str. 2,
            97080 Wuerzburg, GERMANY
FEATURES             Location/Qualifiers
     source          1..9230
                     /organism="Neisseria meningitidis"
                     /mol_type="genomic DNA"
                     /strain="alpha707"
                     /serovar="29E"
                     /db_xref="taxon:487"
     gene            complement(<1..251)
                     /gene="ctrA"
     CDS             complement(<1..251)
                     /gene="ctrA"
                     /function="capsule transport"
                     /codon_start=1
                     /transl_table=11
                     /product="CtrA protein"
                     /protein_id="CAE11281.1"
                     /db_xref="UniProtKB/TrEMBL:Q70JW7"
                     /translation="MEVKKISSFIICGLVLITLTACGAIPSSGPSAKKIVSLGQQSEA
                     QIPEVELIDVNHAVAQSLYKAQMNQSFTQFGDGYASTGTL"
     gene            307..1503
                     /gene="cap29eA"
     CDS             307..1503
                     /gene="cap29eA"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eA protein"
                     /protein_id="CAE11282.1"
                     /db_xref="GOA:Q70JW6"
                     /db_xref="InterPro:IPR007833"
                     /db_xref="UniProtKB/TrEMBL:Q70JW6"
                     /translation="MKIALITQNIKDPINFSSHFLNNLSLIIKEKFNIFLFTDTDKPL
                     LTNYNTKQYNFISPRIKRSNHINLSVTDVNNIKKQINVYKKLGRKHNIWTLVTDYIDI
                     SEFYRKNFIEIRPDVLIVWNGITHSFQTAAVEVAKSFDIPVIFLERGLIPRSIFYDFQ
                     GVNAESEIGQNQQWQQQESLLTDKDIFNNIRKIIIETGGGLVAEKVTRSTLLKQNYIF
                     FPLQRDTDSNMLFNSPYVKNMYSILNGLNNWCHENNNIPKILVRPHPEDPNTHYTKHM
                     NFENLTIQSDGALLETIQKANAIMTVNSTVGFTSLILDKVVIALGKSIYNNRELCIEP
                     KNMNELYATLNCPNDWILNSYMREKRKDFVSKVIANSHISFQHNIFLDIQLLALKNKI
                     YSKILL"
     gene            1516..2154
                     /gene="cap29eB"
     CDS             1516..2154
                     /gene="cap29eB"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eB protein"
                     /protein_id="CAE11283.1"
                     /db_xref="UniProtKB/TrEMBL:Q70JW5"
                     /translation="MKSKELHIFVLSSNQKELNQKTSNSLQLFELFPLEITWINNLVD
                     IKDIHILAPYCLLIPAGDHLTKSYLDGFFAMPKILNYAYQPYYSYIFSKRGSIFYRKN
                     TDITPRTDEINTLLLAPHHSRHIIFPSFLLKKIIEDNIFPENIFWRISQSLIENDICI
                     AVLPDSISIEYLNYTIHHKEEIYKNVFPSIANTIFSHKNFLITQNFSDLYGD"
     gene            2144..3604
                     /gene="cap29eC"
     CDS             2144..3604
                     /gene="cap29eC"
                     /function="putative glycosyl transferase"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eC protein"
                     /protein_id="CAE11284.1"
                     /db_xref="GOA:Q70JW4"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q70JW4"
                     /translation="MEIDTIMSLKDIFEILKKKGMRQKKKLLTPNVLQKQNNLTPAKK
                     NLISIHPNISRDLLSLNFVDYRITTTKVVNEANIIFYNKHFSLDYVRLALELDINYYD
                     MIITIKTFRTGGTDKLLLRYLEGIKFSNPKINIILLILEGDSGEWDDLVPENVTLIYL
                     KKYTKSSFNQTVYNQILQRLIIQFEIKILWNFNCRETYNFTERCSPFIREYLSVWGLV
                     FAHWLRPGSLQEFGMAHENLPFVIDDYDVLISDNKTFTEYLCHQYGWNQDKFKTLYVP
                     NSSESIQVKHHRKGNSLKVLWASGIEWNKGVEILPKIAEKISNLPITIDIYGGTKNKD
                     GEDLLLKLNKDILLKGNIKYKGKFDNFRKLVEEGQYDCFLFTSIIEGMPNVIIEAAER
                     QMSIITPLIGGLGEFLNSENAYIVDNKNDVEKYIIELQKVLENKNTGKFTKEINLAHS
                     YNKKFTLDSFKLSYNSLQDYLYTIKDKKNKRIINEN"
     gene            3594..5162
                     /gene="cap29eD"
     CDS             3594..5162
                     /gene="cap29eD"
                     /function="putative glycosyl transferase"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eD protein"
                     /protein_id="CAE11285.1"
                     /db_xref="GOA:Q70JW3"
                     /db_xref="InterPro:IPR008940"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="InterPro:IPR013026"
                     /db_xref="InterPro:IPR013105"
                     /db_xref="UniProtKB/TrEMBL:Q70JW3"
                     /translation="MKIELINSYKQKKYVEAKYIAKKILLTDAKDYEALFYLANSFLF
                     TGEFKSAKDYFQLIIEYYPDKYQGYEGLYKIYKANGDRYNELIQLKKILENFPNVVHI
                     YKETTLLLLQENLINEAENISLECIKKFPDSYHGYESYAFVLEKKQEWEKALEIWNNI
                     IHKFPNFLAAHLNMLKLHVKIYGYERTTSLFESSSQKFKNTEKIDKLYAIEAEKAFKW
                     NDATEIWSRLLSQYPLNTFFISRKAIALRHVKGIIASREYLFSALKDQPDNLVLKLNI
                     LDTYLIEKKWEYSLLYGNDIIKNVQDTAQKSNIYFKLRIPYRELKKLDELENIFLDLI
                     KENPSIYISWKGYATVPELMLDGNEKLLKKACHRWKRASEKFPNIVEAKIKYGEILLS
                     MQQLDFANQVFIELKRDFPNNFYAWKGWCLAAHHMRNWVEARKRLLETRIKFPSQFNS
                     IYYYLVNVLQNDNRLAEIENSFIWHTKSLFKENIKNSLNECLELSKINIYRIIGNYKK
                     ADEKALELLNGITI"
     gene            5260..5889
                     /gene="cap29eE"
     CDS             5260..5889
                     /gene="cap29eE"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eE protein"
                     /protein_id="CAE11286.1"
                     /db_xref="UniProtKB/TrEMBL:Q70JW2"
                     /translation="MDGKRTQNHYRNYGLQCIDKIAFNSSDTYNYQGFANKTIKYNFL
                     LLRDNYNSWYQIHTDYYRTIIENYIKSGNYKKIVLVGASSGGFAAMMYGQLVHADIVY
                     VQAPQTLAFTSYSTQFNKELELQYNLSSTAYTSIAKLQNQSNGFIPKVYVQVCENNGI
                     DMFSINMLNTSDPNLFVHKYKNDTHSVHTIIGKSKMFQDICSIIDDLQK"
     gene            5961..6812
                     /gene="cap29eF"
     CDS             5961..6812
                     /gene="cap29eF"
                     /codon_start=1
                     /transl_table=11
                     /product="KDO 8-phosphate synthase"
                     /protein_id="CAE11287.1"
                     /db_xref="GOA:Q70JW1"
                     /db_xref="HSSP:P0A715"
                     /db_xref="InterPro:IPR006218"
                     /db_xref="InterPro:IPR006269"
                     /db_xref="UniProtKB/TrEMBL:Q70JW1"
                     /translation="MPNINLPTFNIKISNSLPFTLFGGINVLEDLDSTLFACEKYVEV
                     TEKLKIPYVFKASFDKANRSSIHSYRGVGLEEGMNIFSAVKDRFGVPVITDVHEPYQC
                     NAVAEVVDILQLPAFLARQTDLVFAMAQTGRVINIKKPQFLSPEQMKNIVEKFKEAGN
                     DQLILCERGANFGYDNLVVDMLGFGVMKKTCDDLPVIFDVTHALQKRDSGSSASGGRR
                     EQVLDLAMAGMATGLAGLFLEAHPNPDKARCDGPSALPLDKLEDFLLRVKAVDETVKS
                     FPKLDIA"
     gene            6812..8101
                     /gene="cap29eG"
     CDS             6812..8101
                     /gene="cap29eG"
                     /function="CMP-KDO synthetase and KDO 8-phosphate
                     phosphatase"
                     /codon_start=1
                     /transl_table=11
                     /product="Cap29eG protein"
                     /protein_id="CAE11288.1"
                     /db_xref="GOA:Q70JW0"
                     /db_xref="HSSP:P04951"
                     /db_xref="InterPro:IPR003329"
                     /db_xref="InterPro:IPR004528"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006549"
                     /db_xref="InterPro:IPR010023"
                     /db_xref="UniProtKB/TrEMBL:Q70JW0"
                     /translation="MNTENLKTVIVVPARYASTRLPGKPLADICGKPMIQHVYERACK
                     VPYIDDVIVAVDDRRVAEVVESFGGKVIMTSTQHDSGTDRLVEVMGKYAADIYINIQG
                     DEPLIRSEDIALLAQGMKDEQISVGTLCHALPASEATNPNTVKVVLSANGNALYFSRS
                     PIPYPRDKEHAYYFKHIGVYAYRKETLAKYSNLKQPDIELSEKLEQLRLLDAGIDIRV
                     FEVPETGPGVDTPECLERVRAIMSGQLPIDKHSVNLADIRLVITDVDGVLTDGGIFYN
                     ENGECLKRFHVRDGLGIRLLEESGIKVAVLSGRDSPTLRKRIDDLGISYYQLGIKDKH
                     AACIELMQEANCLKEQTAYIGDDTIDLPAFSACGLSFAVADTPEYIRNQADITLTLPG
                     GYGAFRELADKILAAQGKEDVFSSEAGFAQVMHGANQ"
     gene            8128..9075
                     /gene="cap293H"
     CDS             8128..9075
                     /gene="cap293H"
                     /codon_start=1
                     /transl_table=11
                     /product="D-arabinose-5-phosphate isomerase"
                     /protein_id="CAE11289.1"
                     /db_xref="GOA:Q70JV9"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR001347"
                     /db_xref="InterPro:IPR004800"
                     /db_xref="UniProtKB/TrEMBL:Q70JV9"
                     /translation="MKTNFLKLAVETLQLEANAIMEMSKRLDNEFEKAIEIILNTQGR
                     VVVVGMGKSGIIGQKLAATMASTGTSAFFVHPGEAFHGDLGMIKPIDVALLISNSGET
                     EEIIRILPFLKEQGNKIIAMTGNIKSTLAKHAHSLLDISVSREACSNNLAPTSSTTCT
                     LAMGDALAMVLQSEKKFLPEDFARFHPGGSLGRRLLTRVSDVMKTKIPHCLPDASFKE
                     IVYSINRGYMGLTLVMEHDTLHGIITDGDLRRAFDRFDNINQIKAKDIMSLSPKYVSA
                     DARFAEAEAYMHAEKIDSLVVKESNKVIGVLNIYDIDHY"
     gene            9149..>9230
                     /gene="galE"
     CDS             9149..>9230
                     /gene="galE"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase"
                     /protein_id="CAE11290.1"
                     /db_xref="GOA:Q70JV8"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="UniProtKB/TrEMBL:Q70JV8"
                     /translation="MKVLVTGGTGFIGSHTAISLIKAGYDV"
ORIGIN      
        1 agcgtaccgg tagaagcata accatcgcca aactgggtaa aagactgatt catctgagct
       61 ttatacaaag actgcgccac agcatgattg acgtcaatca actccacttc aggaatttga
      121 gcttcggact gttgccctaa ggagacaatc tttttagcac ttggacctga ggaaggaatg
      181 gctccacatg ccgtcagcgt aataagtacc aaaccgcaga tgataaaaga agatattttt
      241 tttacttcca taatataacc taatcaacta aaataatgtt tttgctagac acttccggag
      301 aggaaaatga aaattgcttt aattacacaa aatattaagg acccaatcaa ttttagttca
      361 cattttttaa ataacctttc attgataata aaggaaaaat tcaatatttt tttattcaca
      421 gatacagata aacctctcct aaccaactat aatacaaaac aatataattt catttcgcct
      481 agaatcaaaa gatccaatca tatcaatcta tctgttactg atgtaaataa tataaaaaaa
      541 cagatcaatg tttataaaaa actagggaga aaacataaca tatggacact agtaactgat
      601 tatatagata tttctgagtt ttaccggaaa aattttattg aaattcgacc tgatgtacta
      661 attgtatgga atggcatcac tcactctttt caaacggcag cagttgaagt tgctaaatcc
      721 tttgatattc cagtaatttt cttagagcga ggactaatcc caagaagcat tttttatgat
      781 tttcaaggag tgaatgctga gtcagaaatt ggccaaaacc aacaatggca acaacaagaa
      841 agtttactaa ctgataaaga tatatttaat aatatacgta aaattattat agaaacaggg
      901 gggggattgg ttgcagaaaa agtaactcgt agtactctac taaaacagaa ttatatcttt
      961 tttcctctac aaagagatac agatagcaat atgttattta actctccata tgttaaaaat
     1021 atgtattcaa tcttaaatgg attaaataat tggtgtcacg aaaataataa tatccctaag
     1081 atattagtaa gacctcatcc tgaggatcct aatacccact atactaaaca tatgaacttt
     1141 gaaaatttaa ctattcaatc tgatggtgca cttttagaaa ctattcaaaa agctaatgca
     1201 ataatgactg taaactcaac agttggattc acttcattaa ttttagataa agtagttatt
     1261 gcattaggaa aatctattta taataatcgg gaactatgta ttgagcctaa aaatatgaat
     1321 gaactttatg caacattgaa ttgcccaaat gactggatac ttaatagtta catgagagaa
     1381 aaacggaaag attttgtatc aaaagtaatt gcaaacagcc atatctcttt tcaacataat
     1441 atttttcttg atattcaatt actagcatta aaaaataaaa tatattcaaa aatcttatta
     1501 taaggatata atataatgaa atctaaggaa ttacatattt ttgtattatc ctcaaatcaa
     1561 aaggaattaa atcaaaaaac atctaacagt ttacagttat tcgaattatt ccctcttgaa
     1621 ataacttgga ttaataatct tgttgatata aaagatatac acatcttagc tccttattgt
     1681 cttcttatcc cagctggaga tcacttgaca aaaagctatc tagatggttt ttttgccatg
     1741 cccaaaatac taaattatgc atatcaacct tattatagtt atattttttc aaaacgtggt
     1801 tctatttttt atagaaaaaa tacagatatt actcctagaa ctgatgaaat aaatacatta
     1861 ttactggccc ctcatcattc tcgacatatt attttcccat catttttgtt aaaaaaaata
     1921 attgaagata acatattccc agaaaatatt ttttggcgaa tatctcagtc ccttatagaa
     1981 aatgatattt gcattgctgt tcttcctgat tcaattagta tagaatattt aaattataca
     2041 atccatcata aagaagaaat atataaaaat gtttttcctt caatagctaa taccattttt
     2101 tctcataaaa attttctgat aacccaaaac ttttctgatt tatatggaga ttgatacaat
     2161 catgtcatta aaagatattt ttgaaatttt gaaaaaaaaa ggaatgcgtc aaaaaaagaa
     2221 attattgacg ccaaacgttt tacagaaaca gaataactta actccagcaa aaaagaattt
     2281 aatttctata catccgaata ttagtaggga tcttttatct ttaaattttg tagattatcg
     2341 gattactact actaaagtag taaatgaagc aaatataatt ttttataata aacatttttc
     2401 tctagactat gttcgattag cccttgaact agatattaac tattacgaca tgataataac
     2461 cataaaaaca tttcgtacgg ggggaacaga caaattatta ttacgatatc tagaaggaat
     2521 caaatttagc aaccctaaaa ttaatattat tttactaata ttagaaggag attcaggaga
     2581 atgggatgat cttgtcccag aaaatgtaac gctcatttat ttaaaaaaat atacaaaatc
     2641 ttcatttaat cagactgttt ataatcagat tctacaaaga ttaataattc aatttgagat
     2701 taaaatctta tggaatttta attgtaggga aacatataat tttacagaaa gatgctcccc
     2761 attcatacgt gaatatttat cggtgtgggg attagttttt gctcattggc tgcgaccagg
     2821 aagtttacaa gaattcggca tggctcacga aaatttgcca tttgtgattg atgactacga
     2881 tgtattgatt tctgacaata aaacatttac cgagtattta tgtcaccaat atggctggaa
     2941 tcaagataaa ttcaaaactt tatatgtgcc caactcttca gaatctattc aagttaaaca
     3001 ccatcgtaaa ggtaactcac taaaagtttt atgggcttca ggtatcgaat ggaataaagg
     3061 tgtagaaatt cttcctaaaa ttgcagaaaa gatttcaaac ttaccaatta ctattgatat
     3121 ttatggaggt actaaaaata aagatggtga agacttatta ttaaagctta ataaagatat
     3181 tttattaaag ggaaatatta aatataaagg taaatttgat aatttcagaa aattagtaga
     3241 agaaggccag tatgattgtt ttctatttac aagtataatt gaaggaatgc caaatgttat
     3301 tatagaagca gctgagagac aaatgtcaat cattactcct cttattgggg ggcttggtga
     3361 attcttaaac tcagaaaatg catatattgt tgacaataaa aatgatgtgg aaaaatatat
     3421 aatagagtta caaaaagttt tagagaataa aaatactgga aaatttacaa aagaaattaa
     3481 cttagctcat agttataaca aaaaatttac cctcgatagt tttaagttat catataattc
     3541 tttacaagat tatttgtata ctattaagga taagaaaaat aaaaggatta taaatgaaaa
     3601 ttgaattaat taattcatat aaacagaaaa aatatgtaga ggcgaaatat attgctaaaa
     3661 aaatattact tacggatgca aaagattatg aggccttatt ctatcttgca aacagctttt
     3721 tatttacagg agaattcaaa agcgcaaaag actactttca gttgattata gaatattacc
     3781 ctgataaata ccaaggatac gaaggcttat ataagattta taaagccaat ggagataggt
     3841 ataatgaatt aatccaacta aagaaaattt tagaaaattt cccaaacgtt gttcatatat
     3901 ataaagaaac tactttgctt ctactacaag aaaatttaat aaatgaagct gagaatatta
     3961 gccttgagtg tattaaaaaa tttcctgatt cctaccatgg atatgaaagc tatgcttttg
     4021 tattagaaaa aaagcaagag tgggaaaaag cacttgaaat atggaataat atcattcata
     4081 aatttcctaa tttcttagca gcacatttaa atatgctgaa attacacgtg aaaatttatg
     4141 gctatgaaag gactacctca ctatttgaga gtagttctca aaagtttaaa aatactgaga
     4201 aaatagataa attatatgca attgaagctg aaaaagcctt taaatggaat gatgctacag
     4261 aaatctggtc acgactgctt tctcagtatc ctctaaatac cttttttata tcccgcaaag
     4321 caatagcact aagacatgta aaaggcataa tagcctctcg agaatattta ttttctgcac
     4381 tcaaggatca gcctgataat ttagtattaa aactaaatat attagatact tacttaattg
     4441 aaaaaaaatg ggaatattct ctattatatg gaaatgacat tataaaaaac gtgcaagata
     4501 ctgcacaaaa atcaaatatt tattttaaac ttcgaatccc ttatcgtgaa ttgaaaaaat
     4561 tagatgaact agaaaacatt tttttagatt taattaaaga gaatccgagt atttatatta
     4621 gctggaaagg ttatgctaca gttccagaat taatgttaga tggtaatgaa aaacttctaa
     4681 aaaaagcttg tcatcggtgg aaaagagcct ctgaaaaatt tccaaatatc gttgaggcta
     4741 aaataaaata tggtgagatt cttttgtcta tgcaacagct agattttgct aaccaagttt
     4801 ttattgaact taaacgagac tttccaaata acttttatgc atggaaaggt tggtgcctag
     4861 ctgctcatca tatgagaaat tgggtagaag ctcgtaaaag gcttttagaa actcgtatta
     4921 aatttccaag tcagtttaat agcatttatt attatttagt taatgtatta caaaatgata
     4981 atagactagc cgaaatagag aactccttta tctggcatac taaatctttg tttaaagaga
     5041 atataaaaaa ctcccttaat gaatgtttag aactatctaa aattaatatt tacaggatta
     5101 taggaaatta taaaaaagct gatgagaagg cattagagtt attaaacggt attaccattt
     5161 aaagatccta ctactctgcc aaaacctcag aaatctaata tctctcaata tattgaacat
     5221 tctaaaaata atgaaacttt agttatatgc ttttcaggca tggatggtaa acgcactcaa
     5281 aatcattata gaaattatgg gttacaatgt atagataaaa ttgcttttaa ttctagtgat
     5341 acttataatt atcaaggttt tgctaacaaa accataaaat ataattttct cttactaaga
     5401 gataattata acagttggta tcaaatacat acagattatt atagaacgat cattgaaaac
     5461 tatataaaat ctggcaatta taaaaaaata gtattagttg gagcttcatc tggaggcttt
     5521 gcagctatga tgtatggaca gttagtacat gccgacattg tatatgttca agctcctcag
     5581 acattagctt tcacaagcta ctcaacacaa tttaataaag agctagagct tcaatataat
     5641 ttaagttcta ctgcatatac aagtattgct aagcttcaaa atcaatcaaa tggatttatt
     5701 cccaaagtat atgttcaagt ttgtgaaaac aatggaattg atatgttttc tatcaatatg
     5761 cttaatactt ctgatcctaa tttatttgtt cacaaatata aaaatgatac tcattctgtt
     5821 catacaatta taggaaaatc aaaaatgttt caagacatat gtagtataat agatgattta
     5881 caaaaataat ttcttattga ataaaaattc aatcattaaa ttagatctaa aaaatttatt
     5941 tttaatcaag gattttaaaa atgcctaata ttaatttacc aaccttcaat ataaaaatta
     6001 gtaatagcct accctttaca ttatttggag gaattaatgt cttagaagac ctagattcca
     6061 ctttatttgc ctgtgaaaaa tatgttgaag taacggaaaa attaaaaatc ccatatgtat
     6121 ttaaagcatc ttttgataaa gccaatcgct cttcaattca ttcttaccgc ggagtaggcc
     6181 ttgaagaagg catgaacatc ttttctgcgg ttaaagaccg ttttggtgtc cctgtgatta
     6241 cagatgtgca tgagccatat caatgtaatg cagttgctga agtagtggat attttgcaat
     6301 taccggcctt tcttgcccgc caaactgatt tggtattcgc catggctcaa accggtagag
     6361 ttatcaacat taaaaaacct caatttctta gccctgaaca gatgaaaaat attgtggaga
     6421 aattcaaaga ggctggcaat gaccaattga tcttatgtga acgtggcgct aattttggct
     6481 atgataattt ggttgtcgat atgctgggct tcggtgtaat gaagaaaact tgcgatgatt
     6541 taccggttat ttttgatgta acacatgctc ttcaaaaacg tgattcaggc tcctctgctt
     6601 ccggtgggcg tcgtgagcaa gttttggatt tagcaatggc cggcatggca actggtttag
     6661 caggtttatt cttggaagct catccaaatc ctgataaagc gcgttgtgat ggcccaagtg
     6721 ctcttcctct agataaattg gaggatttct tgttacgtgt gaaagctgtg gatgaaacag
     6781 ttaaatcatt tcctaaattg gatattgctt aatgaatacc gaaaatctga aaacggttat
     6841 tgttgttcct gcacgctatg cttctactcg tttacccgga aagcctttgg ctgatatctg
     6901 cggtaaacca atgatccaac atgtctatga acgtgcttgt aaagtaccct atattgatga
     6961 tgtgatcgtt gctgttgatg atcgtcgtgt tgctgaagtt gtagaatctt ttggtggcaa
     7021 agttatcatg acttctactc aacatgattc tggtacagat cggttagttg aagtaatggg
     7081 aaaatatgct gctgatattt atattaatat ccaaggagat gagccattaa ttcgatctga
     7141 agatattgct ttgctcgctc aaggcatgaa ggatgagcaa atctcagtgg gcaccctttg
     7201 tcatgctcta cctgcttcag aagcaactaa tccaaatact gtcaaagtcg tactatctgc
     7261 aaacggtaat gcactttact ttagtcgtag ccctattcct tatcctcgag ataaagagca
     7321 tgcttattat ttcaaacata tcggcgttta tgcttatcgt aaggaaactc tagcaaaata
     7381 cagtaacctc aagcagcctg atatagagct aagtgagaaa ctggaacagt tgcgtttatt
     7441 agatgccggc atcgatattc gggtttttga agtacctgaa acaggaccgg gtgtagatac
     7501 accagaatgc ttagaacgtg tacgcgccat catgtcaggc cagcttccta ttgataaaca
     7561 ttcggtcaat ttagctgata ttcgtctcgt tattaccgac gttgatggtg tactaacaga
     7621 tggcggtatt ttctacaatg aaaatggaga atgtttaaaa cgttttcatg tacgagatgg
     7681 tttaggtatt agattgcttg aggaatcagg cattaaagta gcggtattat caggaagaga
     7741 ttctcccacc ctgcgaaaac gaattgatga tttaggtatt tcttattatc aactcggcat
     7801 taaagacaaa catgcggcat gtattgagtt aatgcaagaa gctaattgtc ttaaagagca
     7861 aacagcatat atcggtgatg acaccatcga tctacctgct ttctccgctt gtggtttaag
     7921 ttttgctgtc gcagatacgc ctgaatatat acgtaatcaa gcagacataa ctttaacatt
     7981 accaggaggc tatggggcat ttcgtgagtt agcagataaa attcttgctg ctcagggcaa
     8041 ggaggacgtt ttttcttcag aagctggatt tgctcaagtt atgcatggtg ctaaccagta
     8101 atcataaaaa aataatagga gttaataatg aaaactaact ttctaaaatt ggcggttgaa
     8161 accttacaat tagaagctaa tgccattatg gaaatgagta agcgcttaga taatgaattt
     8221 gagaaagcaa tagaaattat cttaaatact caaggtcgcg tagttgtggt agggatggga
     8281 aaatctggga ttatcggtca aaagcttgct gcaactatgg cttctaccgg tacttctgct
     8341 ttttttgtcc atcctggtga ggcatttcat ggcgatttag ggatgattaa accaatagac
     8401 gttgccttat taatttcaaa ttcgggagaa actgaggaaa ttatccgaat tcttcctttt
     8461 ctgaaagagc aaggcaataa aattattgcc atgaccggta atattaaatc aactttagcc
     8521 aaacatgctc attctttact ggatatcagt gtatcacgtg aggcttgttc aaataatctt
     8581 gcgccaacct catcaacaac ctgtacactt gcaatgggcg atgcattggc aatggtttta
     8641 caatctgaaa aaaaattctt gcccgaagat tttgctagat ttcatcctgg tggcagctta
     8701 ggccgccgtc tgttaacgcg tgtttcagat gtgatgaaaa ccaaaattcc gcattgccta
     8761 cccgatgctt cctttaaaga aattgtatat agtattaatc gaggttacat ggggctaacc
     8821 ttggtaatgg agcatgatac gcttcatggc attattactg atggagattt acgtcgtgcc
     8881 ttcgatagat ttgataatat caatcaaatt aaagcaaaag acataatgtc tttatctcct
     8941 aaatatgttt ctgctgatgc ccgctttgca gaagctgaag cctatatgca tgctgaaaaa
     9001 attgattcat tagtcgtaaa agagtccaat aaagtaattg gcgttttgaa tatttacgat
     9061 attgatcatt attaaaaagc taactgctaa ttacgaatta tttcaaatat aatgtaatta
     9121 actctaaact aaataaagtt aaagaataat gaaagtcctc gttacgggcg gaaccggttt
     9181 tatcggttca cataccgcca tctcactaat taaagcaggt tatgatgttg
//

