LOCUS       HQ437686               24676 bp    DNA     linear   BCT 01-FEB-2012
DEFINITION  Neisseria meningitidis strain CMCC29044 capsular gene cluster,
            partial sequence.
ACCESSION   HQ437686
VERSION     HQ437686.1
KEYWORDS    .
SOURCE      Neisseria meningitidis
  ORGANISM  Neisseria meningitidis
            Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
            Neisseriaceae; Neisseria.
REFERENCE   1  (bases 1 to 24676)
  AUTHORS   Zhu,H., Wang,Q., Wen,L., Xu,J., Shao,Z., Chen,M., Chen,M.,
            Reeves,P.R., Cao,B. and Wang,L.
  TITLE     Development of a Multiplex PCR Assay for Detection and Genogrouping
            of Neisseria meningitidis
  JOURNAL   J. Clin. Microbiol. 50 (1), 46-51 (2012)
   PUBMED   22090406
REFERENCE   2  (bases 1 to 24676)
  AUTHORS   Zhu,H., Wang,Q., Xu,J., Shao,Z. and Wang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2010) TEDA School of Biological Sciences and
            Biotechnology, Nankai University, No. 23, Hongda Street, Tianjin
            300457, China
FEATURES             Location/Qualifiers
     source          1..24676
                     /organism="Neisseria meningitidis"
                     /mol_type="genomic DNA"
                     /strain="CMCC29044"
                     /db_xref="taxon:487"
                     /note="serogroup: I"
     misc_feature    1..>24676
                     /note="capsular gene cluster"
     gene            complement(294..1553)
                     /gene="lipB"
     CDS             complement(294..1553)
                     /gene="lipB"
                     /note="capsule polysaccharide modification protein"
                     /codon_start=1
                     /transl_table=11
                     /product="LipB"
                     /protein_id="AEQ62023.1"
                     /translation="MKQTVLKNNLQSLLESAENILLLQGPVGDFFLRLADWLTANGKT
                     VHKFNFNAGDGYFYPPTQAHTVVFNDNYDAFPEFLQEYITQHHIQAVVCFGDTRPYHV
                     IAKRIANENQASFWAFEEGYFRPYYITLEKDGVNAFSPLPRRADFFLEQFPKLAQQEY
                     KAPTPVHGGFTPMAKNAIRYYIELFRNPRKYPDYIHHRAPNAGHYLKLWSLSILKRLN
                     YYIEDIQIAKRVEAGKYGKFFIVPLQVFNDSQVRIHCDFPSVRSFLLHVLSSFAEHAP
                     ADTNIIIKHHPMDRGFIDYWRDIKRFIKEHPELQGRVIYVHDVPLPVFLRHGLGMVTI
                     NSTSGLSGLIHNMPVKVLGRAYYDIPGITDQNTLAEFWNHPTPPDKELFHAYRMYHLN
                     VTQINGNFYSQVFFPNKKTSDSSTPAT"
     gene            complement(1690..3714)
                     /gene="lipA"
     CDS             complement(1690..3714)
                     /gene="lipA"
                     /note="capsule polysaccharide modification protein"
                     /codon_start=1
                     /transl_table=11
                     /product="LipA"
                     /protein_id="AEQ62024.1"
                     /translation="MIFSTFGLFKQRLLLTKFLDKISTDKTALFWGKKHPKRRKLAHI
                     LRLSLLNLEDGFLRSLGLGVAGYPPYSIVYDDIGIYYDTTRPSRLEQLILAADTMPSE
                     TLAQARQAMDFILQHHLSKYNHAPELSDDHPLRSPSKPETVLIIDQTFGDMAIQYGGA
                     DASTFELMFQTALNENPQADIWVKTHPDVLCGKKQGYLTQLAQQHRVHLLAEDINPIS
                     LLQAVDKVYCVTSQMGFEALLCGKPLVTFGLPWYAGWGVSDDRHPEINRLVQTQRRAT
                     RNLLQLFAAAYLQYSRYLNTNTGEAGSLFDVIDYLATVKRKNDKLRGELYCVGMSLWK
                     RAVAKPFFNVPSCRLKFISSTQKLARVKLSDDARILAWGNGKEAIVRFAEQHHIPLLR
                     MEDGFIRSVGLGSNLVPPLSLVTDDMSIYFNAETPSRLEYILQNQNFDDQDFQTALKL
                     QKMLTENHISKYNVGSSDFTAPSTDKTVILVPGQVEDDASIRYGSPQIYRNLDLLRTV
                     RERNPNAYIIYKPHPDVVSGNRIGHISPEDAARYADQTAEQTDILTCLQYADEVHTMT
                     SLTGFEALLRGKKVSCYGLPFYAGWGLTQDLLPIPRRSRRLELWQLIAGTLIHYPDYI
                     HPETHQAINAETAAQILIRQKNMQKNNNGLHRGYFAKKLGKIKQLYRSFK"
     gene            complement(3759..4880)
                     /gene="sacB"
     CDS             complement(3759..4880)
                     /gene="sacB"
                     /note="capsular polysaccharide phosphotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="SacB"
                     /protein_id="AEQ62025.1"
                     /translation="MNLNKIRKFFRESHIFFRDFLNKRFPPYNVEQPIPETEEFTLIN
                     ADANLASLTENVLPNFPIDVVFTWVDNTDKAWQEQYYRTLQPIDQEDIGLYATDPARF
                     SNHNELFYSVQAVQKFMPWVRNIFIVTADQKPKWLDENIHSKIKLINHSQLIDAKYLP
                     TFNSHVIEANLYKIPDLSEHFIYFNDDVFVARPLMPNHFFENNGLASLFVANKSFQKM
                     RQRGLITPTLTASEHALKLLKRHYPTININTPLVHTYVPLRKTSFQKAWSLFEDEINS
                     FLNNKVRHNSELNMASFLIPWLMYLDGYATPKREICYYFNIRSSHAQTQYKKLLFEKE
                     HLHMPHSFCINDSSSNNADKNYALHFRNFMDTYFEIETE"
     gene            complement(4936..5478)
                     /gene="rmlC"
     CDS             complement(4936..5478)
                     /gene="rmlC"
                     /note="dTDP-4-dehydrorhamnose 3,5-epimerase; RfbC"
                     /codon_start=1
                     /transl_table=11
                     /product="RmlC"
                     /protein_id="AEQ62026.1"
                     /translation="MNIIDTALPDVKILKPQVFKDGRGFFMETFRDGWFKENIADCSF
                     VQENHSKSGKGVLRGLHYQTENTQGKLVRVVVGEVFDVAVDMREGSPTFGKWTGATLS
                     AQNQYQLWIPEGFAHGFYVLGDAAEVVYKCTDYYNPKAEHSLIWNDPTVGIDWPLQGE
                     PNLSPKDLAGKVLAEAVTFG"
     gene            complement(5523..6533)
                     /gene="rmlA"
     CDS             complement(5523..6533)
                     /gene="rmlA"
                     /note="glucose-1-phosphate thymidylyltransferase; RmlA"
                     /codon_start=1
                     /transl_table=11
                     /product="RmlA"
                     /protein_id="AEQ62027.1"
                     /translation="MVSGQQNLVAKCIERQLSFGTFRYWKIVFRRHPDAMPSENPSQR
                     KKEKMKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILVITA
                     PEDNASFKRLLGDGSDFGISISYAVQPSPDGLAQAFIIGEEFIGNDNVCLVLGDNIFY
                     GQSFTQTLKQAAAQTHGATVFAYQVKNPERFGVVEFNENFRAVSIEEKPQRPKSDWAV
                     TGLYFYDNRAVEFAKQIKPSARGELEITDLNRMYLEDGSLSVQILGRGFAWLDTGTHE
                     SLHEAASFVQTVQNIQDLQIACLEEIAWRNGWLEKKDVETRAKPLEKTAYGQYLLHLI
                     GK"
     gene            complement(6452..7534)
                     /gene="rmlB"
     CDS             complement(6452..7534)
                     /gene="rmlB"
                     /note="dTDP-glucose 4,6-dehydratase; RfbB"
                     /codon_start=1
                     /transl_table=11
                     /product="RmlB"
                     /protein_id="AEQ62028.1"
                     /translation="MQTANKKTILVTGGAGFIGSAVVRHIIRNTQDSVVNLDKLTYAG
                     NLESLTDIADNPRYAFEQVDICDRAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEF
                     IQTNIVGTFNLLEAARAYWQQMPSEQHEAFRFHHISTDEVYGDLGGTDDLFTETAPYA
                     PSSPYSASKASSDHLVRAWLRTYGLPTIVTNCSNNYGPYHFPEKLIPLMILNALDGKP
                     LPVYGDGMQIRDWLFVEDHARALYQVVTEGVVGETYNIGGHNEKANIEVVKTICTLLE
                     ELVPEKPAGVARYEDLITFVQDRPGHDVRYAVDAAKIRRDLGWLPLETFESGLRKTVQ
                     WYLDNKTWWQNVLNGSYRLERLGTGK"
     gene            complement(7535..8551)
                     /gene="galE"
     CDS             complement(7535..8551)
                     /gene="galE"
                     /note="UDP-glucose 4-epimerase"
                     /codon_start=1
                     /transl_table=11
                     /product="GalE"
                     /protein_id="AEQ62029.1"
                     /translation="MNILVTGGTGFIGSHTVISLLKSGHQVVILDNLCNSSINILPRL
                     KTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVS
                     GSLVLVEEMARTGVFSIVFSSSATVYGDPGKVPYTEDMPPGDTANPYGASKAMVERML
                     TDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVF
                     GGDYPTPDGTGMRDYIHVMDLAEGHIAAMKAKGGVAGVHLFNLGSGRAYSVLEIIRAF
                     EAASGLTIPFEIKPRRAGDLACSFADPSHTKQQTGWETKRGLQQMMEDSWRWVSRNPN
                     GYGD"
     CDS             complement(8581..9231)
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="AEQ62030.1"
                     /translation="MRRSRLSQYKQNKLIELFIAGVTARTAAQLVGVNKNTTAYYFHR
                     LHLLIFHNSPHLEMFDGEVEVDESYFGGQRKGKRGRGAAGKVAVFGLLKRNGKVYTVA
                     VPNTQTATLLPIIREQVKPDSIVYTDCYKSYDVLDVSEFSHFRINHSTHFAERQNHIN
                     GIENFWNQAKRHLRKFNGIPKEHFELYLKECEWRFNHSEIKVQIFILKQLVKQNLF"
     mobile_element  complement(<8581..>9231)
                     /mobile_element_type="insertion sequence:IS1016-like"
     mobile_element  complement(9272..10116)
                     /mobile_element_type="insertion sequence:IS1301"
     misc_feature    complement(9284..9628)
                     /note="similar to transposase orf2; ISS0d6"
     misc_feature    complement(9616..10035)
                     /note="similar to transposase orf1; ISS0d6"
     gene            10245..11369
                     /gene="mnaA"
     CDS             10245..11369
                     /gene="mnaA"
                     /note="UDP-N-acetylglucosamine 2-epimerase; WecB"
                     /codon_start=1
                     /transl_table=11
                     /product="MnaA"
                     /protein_id="AEQ62031.1"
                     /translation="MNATQKFLVVFGTRPEAIKMAPLVDGFKKLNFDFKVCVTAQHRQ
                     MLDQVLKLFEIKPDYDLDIMSSGQTLSDITATILQKIQPVIENYKPTVIFVHGDTATT
                     LATSLAAYYNQIDIAHIEAGLRTGNIYSPWPEEGNRKLTGALAKYHFTPTQGTQENLI
                     KEHVSIDKIYVTGNTVIDALFLASEKIEQDKQLHEKLQSDFEFLSDDKVVLITGHRRE
                     NFGQGFENICKAIAKLSDDNPTVRFVYPVHLNPNVREPVQRLLANKANVHLIEPLDYF
                     SFTYLMKKSYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVQAGTVKLVGTNYEKI
                     VQEVNTLLRDKLQYQMMSEAHNPYGDGTSVEKILKVFKSN"
     gene            11387..12661
                     /gene="mnaB"
     CDS             11387..12661
                     /gene="mnaB"
                     /note="UDP-N-acetyl-D-mannosamine dehydrogenase; WecC"
                     /codon_start=1
                     /transl_table=11
                     /product="MnaB"
                     /protein_id="AEQ62032.1"
                     /translation="MNMYQNKIISVIGLGYIGLPTAAAFAGHGVKVIGVDVNQHAVDT
                     INQGKIHIVEPDLDIAVHQCVTNGTLKATLVPEPAEAFLIAVPTPFKGNDYEPDLSYI
                     EAASKAIAPVLKKGDLVILESTSPVGATEQMAAWLASERADLSFPQQKGEDSDIRIAH
                     CPERVLPGQVMRELIENDRIIGGMTSKCSEQAVALYKTFVKGDCIITNARTAEMCKLT
                     ENSFRDVNIAFANELSIICDKLDINVWELISLANRHPRVNILQPGCGVGGHCIAVDPW
                     FIVNKTPDLAKLIHTARLVNDGKPEWVIGKVDEAVIQVLQKNPTKTVADVKIACLGLA
                     FKPDIDDLRESPALKITEKLAEKYPNQILAVEPNVDELPTKLADKGIKLVQLDDVLAV
                     ADVLVVLVDHKEFKGEQLVDVKGLVVDTKGLV"
     gene            12813..15101
                     /gene="wnmB"
     CDS             12813..15101
                     /gene="wnmB"
                     /note="glycosyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="WnmB"
                     /protein_id="AEQ62033.1"
                     /translation="MLKKFRKNATKTVNSLKKHKIIQQISSANEKRIAKFFDLYLKDK
                     SVPYQLPHHKSERESLILNTYLSNGINGLIGILEKDQTNSKMERSKVYLEAGQIVKKH
                     NKYDAYLLCYMANGLYKSETTCRALGWAALHAKELEIAQMCVQELDEFYQKEGDVQHK
                     KLAERLKLSVSKAVEVLRGDAIKASSIKISYKQDEVVSETFEEHRVDVEFLLALYKQS
                     TREKVVAVIQNSELKQKEKAQLCIQLSKHFRELFKIEQSVYFADQALFFDESATILRG
                     VYWAYKRAGEQSKTDNVLKKLEQNMLTLSRKEQDAIKKLRANYNSTYSVLKVLEDLKS
                     VRKQYPEHAPIKNRICYVLHNSLPYASGGYATRGHGLAKGFLNHGFDIKVVNRPGFPY
                     ETKPELDELHPPKLEQVDGVDYIKISQPRRGVGLTTADYIGQATEALLQEFLELKPEI
                     IIGASNYLTALPALLAARKLGIPFIYEVRGFWEITRLSREPEFAHHPSFKIQVEMESA
                     VVKAADHVFTLTNAMKDELVKRGADISKITLIPNSCNPEQFIPRTKDVALMQKLSFPE
                     NIPVIGYIGTFVIYEGLEYLAEACGKLKQRGIEFRLLLVGNENTAGTNRGEITEMIAQ
                     TVEKYGFTDWLVMPGRIPFKEVESYYSIIDIVPFPRKPWPVCEMVSPMKPLEALAMEK
                     AIVVSSVGALAEMVNPNETGVVFRKGDIDDLADKLQMLISNPDLCKIMGKNGRMWVEH
                     ERTWQKTSDKASSMLKLVLDGK"
     gene            15131..17650
                     /gene="wnmC"
     CDS             15131..17650
                     /gene="wnmC"
                     /note="glycosyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="WnmC"
                     /protein_id="AEQ62034.1"
                     /translation="MDLTQSWDLIPLNGFLYRIFLVDSQTIDEIIEKRSFKPRKDCDN
                     FFLVEPIDWEATHKPSDRNWRMQLQGWFFLNPIMNGFDSYPDKDRLVQFFLDLALSWW
                     DKYKNDADDIVTSRMPSSYAWYDMSVGSRALCLAFFQNRIKVYGLDISEQNKKVIHEM
                     AQKHIRHLSNKAVFSLNNHGIFQAHGLMALAHVFESKASIKEYATELVKRLLDNQFDE
                     NGIHLEHSPHYHFYALSAFRALLRSELYKESQDFNQKIQKAEDKCKWLIDPLKRPICV
                     GDSILTTQNRVMFPTSDSQDFLISDFCESGYSVVRSPWSTSPELASMIFFAGAYHSKS
                     HKHRDCLTFDWFEQGRRIIADSGKYGYKSDKYRNYFLSNKAHNSVEIEGFDILKIKPY
                     GSAVSNPKKIADDIYQLNGTLDYPAIKHNRTLTYRPLSWVIVEDILDFARERHATQWF
                     HLENDFNLVSSAENQLCFQRANEELHIHCLDEDLNLLLHYGDEVSMQGFLSQKDFMFD
                     SAYAIGFKGKFKQKRILTILARSMADLDNAKEFLGVKQPDVSLPNSPLTPQIIKGERH
                     LALSEMNELKRNHLDNKGTFQVVSDNVTFTFFGNFFQDKKKKIVFFFPGATNRSKSKF
                     DMQRFSWSSELNDVETVFFADPTYKPNNDLSIGWFQHTYKDFGIDALEKLIRHITALK
                     GYAQDEMVFFGSSAGGFVSLKLAERFDKSDAICINPQIYLPKYSRDFYQHLLSVCYPG
                     LSEQEVLERFGDRIAVTKDLSQNTGRIIIFQNQYDENHMKNHIGYYLKNHNLINCRLS
                     FENYSPENVENGLSVVIYQDEKLGHSPPSKEITLQWIQDLL"
     gene            17669..18655
                     /gene="wnmD"
     CDS             17669..18655
                     /gene="wnmD"
                     /note="glycosyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="WnmD"
                     /protein_id="AEQ62035.1"
                     /translation="MNVGSMKLYLISDNLTHQSLLLENIDLQESWWWLRKANKPILFV
                     ESAWNGYQDRWEFQIAAYPDYPERNNQKLIKLLEKAKSKGIPTVFWNKEDSVHFDRFI
                     DSAKHFDHIFTVDENCVERYRAVVPASITVDVAMFPVQPRIHNYQGFNFQQLEANFVG
                     SFSRHIHDKRRERQEMLFSAALKAGLPVTIFDRNSDRKSDNYRYPEQEFGLKIMPALD
                     YAQTADIYRRFAVSLNVNTIEDSPTMFSRRVVEILACGGILVSTPGMAMDRLFKDYCH
                     IVNNEDEAVALFERLKYGPSERDLEMAKAGADFVLNNFTWQKFLEKIQSVVF"
     gene            18698..19900
                     /gene="ctrA"
     CDS             18698..19900
                     /gene="ctrA"
                     /note="capsule polysaccharide export outer membrane
                     protein"
                     /codon_start=1
                     /transl_table=11
                     /product="CtrA"
                     /protein_id="AEQ62036.1"
                     /translation="MAKFFILKAGNMNKLFGKPFLALMTGMLLVGCGALPSSGPSAKK
                     VVSLGQQSETQIPEVELIDVNHAVAQSLYKAQVNQSFTQFGDGYASAGTLNVGDVLDI
                     MIWEAPPAVLFGGVLSSMGSGSAHQTKLPEQLVTARGTVSVPFVGDISVVGKTPGQVQ
                     EIIKGRLKKMANQPQVMVRLVQNNAANVSVIRAGNSVRMPLTAAGERVLDAVAAVGGS
                     TANVQDTNVQLTRGNVVRTVALEDLVANPRQNILLRRGDVVTMITNPYTFTSMGAVGR
                     TQEIGFSARGLSLSEAIGRMGGLQDRRSDARGVFVFRYTPLVELPAERQDKWIAQGYG
                     SEAEIPTVYRVNMADAHSLFSMQRFPVKNKDVLYVSNAPLAEVQKFLSFVFSPVTSGV
                     NSINNLTN"
     gene            19915..21078
                     /gene="ctrB"
     CDS             19915..21078
                     /gene="ctrB"
                     /note="capsule polysaccharide export inner-membrane
                     protein"
                     /codon_start=1
                     /transl_table=11
                     /product="CtrB"
                     /protein_id="AEQ62037.1"
                     /translation="MSEQLPVAVATETKAERKKPKKKSWIKKLSPLFWVTVIIPTVIS
                     LVYFGFFASDRFTSQSSFVVRSPKSQSSLNGLGAILQGTGFARAQDDIYTVGEYMRSR
                     SSLDELRKILPVREFYETKGDAFSRFNGFGFRGEEEAFYQYYKNQVMINFDTVSGIST
                     LNVTSFDALESKKINEALLKQGEALINQLNDRARADTVRYAEEVVKTAAERVKEASQN
                     LTDYRIANGVFDLKAQSEVQMGLVSKLQDELIVIQTQLDQVKAVTPENPQIPGLQARE
                     QSLRKEIDQQLRAISGGGHSSLSNQAAEYQRVYLENQLAEQQLAAAMTSLESAKVEAD
                     RQQLYLEVISQPSLPDLAHEPKRLYNIVATLIIGLMVYGILSLLTASIREHKN"
     gene            21078..21875
                     /gene="ctrC"
     CDS             21078..21875
                     /gene="ctrC"
                     /note="capsule polysaccharide export inner-membrane
                     protein"
                     /codon_start=1
                     /transl_table=11
                     /product="CtrC"
                     /protein_id="AEQ62038.1"
                     /translation="MKALHKTSFWESLAIQRRVIGALLMREIITRYGRNNIGFLWLFV
                     EPLLMTFVIVLMWKFLKADRYSTLNIVAFAITGYPMLMMWRNASKRAVGSISSNASLL
                     YHRNVRVLDTILARMILEIAGATIAQIVIMAVLIAIGWIEMPADMFYMLMAWLLMAFF
                     AIGLGLVICSIAFNFEPFGKIWGTLTFVMMPLSGAFFFVHNLPPKVQEYALMIPMVHG
                     TEMFRAGYFGSDVITYENPWYIVLCNLVLLLFGLAMVSKFSKGVEPQ"
     gene            21872..22522
                     /gene="ctrD"
     CDS             21872..22522
                     /gene="ctrD"
                     /note="capsule polysaccharide export ATP-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="CtrD"
                     /protein_id="AEQ62039.1"
                     /translation="MISVEHVSKQYQMRGGMRTVLDDINFSLQKGEKVGILGRNGAGK
                     STLIRLISGVEPPTSGEIKRTMSISWPLAFSGAFQGSLTGMDNLRFICRIYNVDIDYV
                     KAFTEEFSELGQYLYEPVKRYSSGMKARLAFALSLAVEFDCYLIDEVIAVGDSRFADK
                     CKYELFEKRKDRSIILVSHSHSAMKQYCDNAMVLEKGHMYQFEDMDKAYEYYNSLP"
     gene            22586..>24676
                     /gene="tex"
     CDS             22586..>24676
                     /gene="tex"
                     /note="putative transcriptional accessory protein"
                     /codon_start=1
                     /transl_table=11
                     /product="Tex"
                     /protein_id="AEQ62040.1"
                     /translation="MNITQILSQELSATAAQITAAVELLDDGATVPFIARYRKEATGG
                     LDDTQLRRLAERLQYLRELEERKAVVLKSIEEQGKLSDDLRAQIEAADNKTALEDLYL
                     PYKPKRRTKAQIAREHGLQPLADVLLAEQSQDVEAAAQGYLNENVPDAKAALDGARAI
                     LMEQFAEDAELIGTLRDKLWNEAEIHAQVVGGKETEGEKFSDYFDHREPIRAMPSHRA
                     LAVLRGRNEGVLNIALKYQPDDTPITQQSEYEQIIARRFKVSDGHKWLRDTVRLTWRA
                     KIFLSLELEALNRLKEAADTDAITVFARNLKDLLLAAPAGRLTTLGLDPGYRNGVKCA
                     VVDDTGKLLDTVIVYLHQENNMLATLSRLIKQHGVKLIAIGNGTASRETDKIAGELVR
                     EMSKMGLHKIVVSEAGASIYSASELAAREFPDLDVSLRGAVSIARRLQDPLAELVKID
                     PKSIGVGQYQHDVNQSQLAKSLDAVVEDCVNAVGVDVNTASAPLLARISGLNQTLAQN
                     IVAYRDENGAFDSRKKLLKVPRLGEKTFEQAAGFLRINGGKEPLDASAVHPEAYPVVA
                     KMLAQQGISAAELIGNRERVKQIKVSDFTDERFGLPTILDILSELEKPGRDPRGEFQT
                     ASFAEGIHEISDLQVGMILEGVVSNVANFGAFVDIGVHQDGLVHISALSNKFVQDPRE
                     VVKAGDVVKVKVLEV"
ORIGIN      
        1 aaaaatattg cttggcacgg ttttgtagag tgtgttgcct tgccggctta tctttaggat
       61 gtttggcttg ttatattgtt ttgcctaggg atacatccat attttgtgtg ttacaaaggg
      121 ctcaggttga gtcggtatgc gctcatgaca gctcggtcat tatactgttt ttgtaattta
      181 ttgttaatga taaatgcagg tttttgtgtt ttatttacat ggcagtagct aaggtattga
      241 ttgtttcagg ccgtctgaaa tgttttcaga cggcctgaat tatttttgct aagtcaggtt
      301 gctggagtgg aagagtcgga ggtttttttg ttaggaaaaa agacctgact gtagaagttg
      361 ccgttaattt gggtcacgtt gaggtggtac attcggtagg catggaacag ctctttgtca
      421 ggcggtgtcg gatgattcca aaattctgcc aaggtatttt ggtcagtaat accgggaata
      481 tcataatagg cacggccgag aaccttaact ggcatattgt gaatcagtcc ggacaggccg
      541 ctggtgctgt tgatggtaac catgccgaga ccgtggcgca ggaaaacggg cagggggaca
      601 tcatggacat aaatcacacg gccttggagt tcggggtgtt ctttgataaa gcgtttaatg
      661 tcgcgccagt agtcgataaa accgcggtcc atcggatgat gcttgatgat gatgttggta
      721 tcggcaggcg cgtgctcggc aaatgaactc aaaacatgga gcaggaagct gcggacgctg
      781 ggaaagtcgc aatggatacg gacttggctg tcgttgaata cctgtaaggg aacaataaaa
      841 aacttgccgt atttgcctgc ttccacacgt ttggcgattt ggatgtcttc aatatagtag
      901 ttcaaacgct tgaggatgga gagcgaccac agtttgaggt aatggccggc attgggtgcg
      961 cggtggtgga tgtagtcggg gtatttgcgt ggattgcgga acaactcgat atagtaacgg
     1021 atagcgtttt ttgccatggg cgtaaaaccg ccgtgtaccg gcgttggcgc tttatattct
     1081 tgctgggcaa gcttagggaa ttgttcaaga aaaaagtcgg cacggcgcgg caacggggaa
     1141 aatgcgttga cgccgtcttt ttctaaggtg atgtagtagg ggcggaaata gccttcttca
     1201 aacgcccaga aactggcttg gttttcgttt gcaatgcgtt ttgcaatgac gtgataaggg
     1261 cgtgtgtcgc caaagcagac aacggcctgg atgtgatgtt gagtgatgta ttcttgcaaa
     1321 aactcaggaa aggcatcgta gttgtcgtta aaaacaacgg tatgcgcttg agtgggcgga
     1381 taaaaatagc cgtcgcctgc attaaagttg aatttatgta cggttttgcc gtttgcagtc
     1441 agccagtcgg caaggcgcag aaaaaaatcg ccgacagggc cttgaagcag caggatattt
     1501 tctgcgcttt caagcaggct ttgcaggtta tttttgagga cggtctgttt catgttgcaa
     1561 tgtggttttg ttttttatgt aatagtttta ggttgaactt tcaagcatac gccaagagaa
     1621 ttaacgatgc aaaggcaatg atgccgcaat agaggcaagt ttatgacgca tcgttaactt
     1681 tgatggtatt tatttgaaag atcgatatag ttgtttgatt ttacctaatt ttttggcaaa
     1741 gtacccgcga tgtaatccgt tgttgttttt ttgcatattt ttttgtcgta tcaggatttg
     1801 ggctgcggtt tctgcattta tggcctgatg ggtttcgggg tggatgtagt cgggatagtg
     1861 gatgagcgtg ccggcaatca gctgccaaag ctcaagtctg cggctacggc gcgggatggg
     1921 gagcagatct tgggtaagcc cccagcctgc gtaaaaaggc aggccgtagc agctgacttt
     1981 tttgccgcgc aacaaggctt caaaaccggt cagcgaagtc atggtatgta cttcgtctgc
     2041 gtattggaga caggtcagga tgtcggtttg ctcggcggtt tggtcggcat atcgtgcagc
     2101 atcttcaggg gaaatatggc cgatgcggtt accgctgact acatcgggat gcggtttgta
     2161 gatgatatag gcattggggt ttcgttcgcg tacggtacgg agcaaatcca gattgcggta
     2221 gatttggggc gaaccgtagc ggatagacgc atcatcttca acctggccgg gaacgaggat
     2281 cacggttttg tcggttgacg gggcggtgaa gtctgagctg ccgacgttgt atttactgat
     2341 gtggttttcg gtcagcattt tttgcagctt caaggccgtc tgaaagtctt gatcgtcgaa
     2401 gttttggttt tgtaggatgt attcaagacg ggacggggtt tcggcattga aataaatgct
     2461 catatcgtcg gtaacgagcg acagcggcgg cactaagttg gagccgagtc cgaccgagcg
     2521 gataaagccg tcttccatgc gcagcagggg gatgtggtgt tgttcggcaa agcggacgat
     2581 ggcctctttg ccgttgcccc aagccaggat gcgtgcatcg tcggacagtt tgacccttgc
     2641 cagtttttgg gtggaagaga taaatttcag acggcaagag ggtacgttaa agaacggttt
     2701 ggcaaccgcg cgtttccaca aagacatacc gacgcaatat aactcgccac gcaatttgtc
     2761 gtttttacgt ttgaccgtcg ccagatagtc gatgacatca aagaggctgc ctgcttcgcc
     2821 ggtattggtg ttgaggtagc ggctgtattg cagataggct gcggcgaaga gctgcagcaa
     2881 gttgcgggtg gcgcggcgtt gggtttgaac aaggcggttg atttcaggat ggcggtcgtc
     2941 gcttacaccc cagccggcat accacggcaa accaaacgtt accaaaggct tgccgcacaa
     3001 caaggcttca aaacccattt gcgaggtcac gcaatacact ttgtccaccg cttgcagcag
     3061 cgaaatcgga ttaatgtctt cagccaaaag atggacgcgg tgttgctgcg ccagctgggt
     3121 cagatagcct tgttttttgc cgcacaaaac atcgggatgg gtttttaccc agatatcggc
     3181 ttgcgggttt tcattcaagg ccgtctgaaa catcagttca aacgtagagg cgtctgcgcc
     3241 gccatattgg atggccatat cgccgaaggt ttggtcgata atgaggacag tttcaggctt
     3301 ggatggggag cgtaaaggat gatcgtctga aagttcgggc gcgtggttgt atttggacag
     3361 gtggtgttgc aggatgaaat ccatcgcctg ccgcgcctga gccaaggttt cagacggcat
     3421 ggtatcggcg gcaagaatca gttgttccaa acgcgaagga cgggtggtgt cgtagtagat
     3481 gccgatgtcg tcatagacga tggaataggg aggatagccg gcgacaccca gtccgagcga
     3541 tcgtaaaaag ccgtcttcaa gattgagcaa ggacaatctt aagatatgtg ctaattttct
     3601 acgtttggga tgtttcttgc cccaaaataa tgcggtctta tccgttgaaa ttttgtctaa
     3661 aaatttggtt agcaagagac gttgtttaaa taggccgaat gttgaaaaaa tcattttaaa
     3721 ttattatgtt atctattaag tatcattaat gtaaaaattt attctgtctc tatttcaaag
     3781 taagtgtcca taaaattacg gaaatgaagg gcatagtttt tatccgcatt attactgctt
     3841 gaatcgttaa tgcagaagga gtggggcata tgaagatgtt ctttttcaaa taataatttt
     3901 ttatattgag tctgggcgtg tgaactgcgt atattgaaat agtagcaaat ttcacgtttc
     3961 ggtgttgcat atccgtcaag gtacatcaac cagggtatca agaaactggc catattaagt
     4021 tcagaattat ggcgaacctt gttatttagg aaagaattta tttcatcttc aaataatgac
     4081 catgcttttt gaaaggatgt tttccgtagc ggaacgtaag tatgtactaa cggtgtattg
     4141 atattaattg tcggataatg tctttttaag agctttaatg cgtgttctga tgcggtcaat
     4201 gtcggcgtga ttagaccccg ttgacgcatt ttttgaaaac ttttattggc aacaaatagg
     4261 gaagccaaac cattattttc aaaaaagtgg ttaggcatca gtggtcttgc aacgaaaaca
     4321 tcatcattga aataaataaa atgttcactt aaatctggaa ttttatataa gtttgcttca
     4381 atgacgtggg aattgaacgt tggtaagtat ttggcatcaa taagttgcga atgattgatt
     4441 aatttaattt tagaatggat gttttcatct aaccatttag gtttttgatc cgccgttaca
     4501 ataaaaatat tgcggaccca cggcataaac ttttgtacgg cctgtactga ataaaaaagt
     4561 tcattatggt tggaaaagcg ggcagggtcg gtcgcataca ggccgatatc ttcctgatcg
     4621 atgggctgca gggtacggta atactgttct tgccatgctt tatcggtatt gtcgacccaa
     4681 gtaaaaacaa catcgatggg aaagtttggc aaaacgtttt ctgtgagtga tgcaagattg
     4741 gcatctgcat tgatcagagt gaattcttca gtttcaggaa taggctgttc tacattataa
     4801 ggaggaaagc gtttatttag aaaatcccta aagaaaatat gggactctct aaaaaatttt
     4861 ctaattttat ttaaattcat ttgaaacttt ctaatactac aaaatagaaa cagttgattc
     4921 tgttatgttt tgaagttatc caaacgttac tgcttcggcc aatactttgc ctgccaagtc
     4981 tttaggcgac aggttcggct cgccttgcaa tggccagtcg atgccgacgg tcggatcatt
     5041 ccaaatcagc gagtgttcgg ctttggggtt gtaatagtcc gtgcatttgt acacgacttc
     5101 cgccgcgtct cccaaaacgt aaaacccgtg cgcgaagcct tcgggtatcc aaagctggta
     5161 ttggttttgt gccgacaggg ttgcgcctgt ccatttgccg aaagtcggcg aaccttcgcg
     5221 catatcgacg gccacgtcga acacttcgcc gacaaccacg cgtacgagtt tgccttgtgt
     5281 gttttcggtt tggtagtgca ggccgcgcaa tacgcctttg ccggatttgg agtggttttc
     5341 ctgaacaaag gaacagtcgg caatattttc tttgaaccac ccgtcgcgga aggtttccat
     5401 aaaaaagccg cgcccgtctt tgaagacttg cggttttaaa atttttacgt cggggagggc
     5461 ggtgtcgatg atgttcatga ttttctctgt atgccgtctg aagaaagtgg ttcagacggc
     5521 atttatttgc cgatcaggtg cagcaggtat tgcccgtagg cggttttttc caaaggcttt
     5581 gcgcgtgttt ccacatcttt tttctccagc cagccgttgc gccaggcgat ttcttccaga
     5641 caggcgattt gcaggtcttg gatgttttgc acggtttgga cgaacgaagc cgcctcgtgc
     5701 aggctttcgt gcgtaccggt gtccagccac gcgaaaccgc gtcccaatat ttgaacggag
     5761 agcgagccgt cttccaaata catccggttg aggtcggtaa tttccaattc gccgcgtgcg
     5821 gacggtttga tttgtttggc gaactcgacg gcacggttgt cgtagaagta caagccggtt
     5881 accgcccaat cggatttggg ccgttgcggt ttttcttcga tggaaacggc gcggaagttt
     5941 tcgttaaatt caaccacgcc gaaacgttcg gggtttttga cctgataagc aaacacggtt
     6001 gcgccgtgcg tttgcgctgc cgcctgtttc aatgtttgcg taaacgactg accgtaaaaa
     6061 atattgtcgc ccaaaaccaa gcaaacattg tcgttgccga taaattcttc gccgatgata
     6121 aatgcctgtg ccaagccgtc cggactgggt tgcacggcat aactgatgga aatgccgaaa
     6181 tcgctgccgt cgccaagcag gcgtttgaaa gaggcgttgt cttcaggcgc ggtaatcacc
     6241 aaaatatcgc ggattcccgc cagcatcaaa accgacaagg ggtaataaat catcggtttg
     6301 tcgtacacgg gcaggagctg tttggatacg ccgcgcgtga tggggtagag gcgcgtgccg
     6361 ctgccgcctg ccagtatgat gcctttcatc ttttctttct tcctttgcga tgggttttca
     6421 gacggcattg cgtcgggatg ccgtctgaaa actattttcc agtacctaaa cgttccaaac
     6481 gatagctgcc gttcaataca ttttgccacc aggttttgtt gtccagatac cattgcacgg
     6541 ttttgcggag gccggactcg aaggtttcca aaggcagcca gcccaaatcc cgcctgattt
     6601 tggctgcgtc gacggcgtag cgtacgtcat ggccggggcg gtcttgtacg aaagtaatca
     6661 aatcttcata acgcgccaca ccggccggtt tttcaggaac aagctcttcc agcagggtgc
     6721 agatggtttt gacgacttca atattggctt tttcattgtg gccgccgata ttgtaggttt
     6781 cgccgacaac accttcggta acaacctgat acagtgcgcg cgcgtggtct tcgacaaaca
     6841 gccagtcgcg gatttgcata ccgtcgccgt acacaggcag cggtttgccg tcaagcgcgt
     6901 tcagaatcat caaaggaatg agtttttccg gaaaatggta aggaccgtag ttgttggagc
     6961 agttggttac aatggtcggc aagccgtaag tacgcaacca cgcgcggacg aggtggtcgc
     7021 tggacgcttt agaggcagag taggggctgg acggcgcgta gggcgcggtt tcggtaaaca
     7081 aatcgtccgt gccgcctaaa tcgccataga cttcatcggt ggaaatatgg tggaaacgga
     7141 aggcttcgtg ctgttcagac ggcatttgtt gccagtaggc gcgggctgct tcaagtaggt
     7201 tgaatgtgcc gacgatattg gtttggataa actcgcctgc cgaaccgata gagcggtcga
     7261 catggctttc cgccgccaag tgcatcacgg catcgggccg gtgttgtgcg aatacgcggt
     7321 cgagttcggc gcggtcgcaa atgtccactt gctcgaaagc atagcgggga ttatcggcaa
     7381 tgtcggtcag cgattcgaga ttgcccgcgt aggtcagttt gtcgaggttg acgacggaat
     7441 cttgggtgtt tcggataata tgacggacaa cggcagaacc gataaagccc gcaccgccgg
     7501 taacgaggat ggtttttttg tttgcggttt gcatttaatc cccatatccg ttggggttgc
     7561 ggctgaccca acgccacgaa tcttccatca tttgctgcaa gccgcgtttg gtttcccagc
     7621 cggtttgttg tttggtatgg gacgggtcgg caaaggaaca cgccaaatca ccggcgcggc
     7681 gcggtttgat ttcaaatgga atggttaaac ccgaagccgc ttcgaaggca cggatgattt
     7741 ccaaaacgga ataggcgcgc cccgaaccca agttgaacaa atgtacgccg gcaacgccgc
     7801 cttttgcctt cattgccgcg atatgccctt ctgccaaatc catcacatga atgtagtcgc
     7861 gcattcccgt accgtcgggg gtcggataat cgccgccgaa taccgacagt tgcggcagcc
     7921 tgcccgaagc cacttggcag atatagggca aaaggttgtt gggaataccg ttgggctgtt
     7981 cgccgatcaa gccgctttcg tgcgccccaa tcgggttgaa ataacgcaac aaaatcacgc
     8041 tccaacgcgg atcggccttt tggatgtcgg ttaacatccg ttccaccatc gctttggatg
     8101 cgccataagg attagcggta tcgcccggcg gcatgtcttc agtataaggt actttgcccg
     8161 ggtcgccata aaccgtcgct gaagagctga acacaatact aaacacgccc gtgcgcgcca
     8221 tttcttctac caacaccaag ctgcccgaaa cattattatc ataatacttc atcggctcgg
     8281 ccacactttc gcctaccgct tttaagccgg caaaatgaat taccgaatca atgcggtttt
     8341 ccgcaaaaat acggcgcaaa atttcacgat cgcggatatc accttgataa aacggaatct
     8401 cttggccggt aatcgttttc aagcgtggca ggatattgat gctggaattg cacaggttat
     8461 ctaaaatcac cacctgatgg ccgcttttca gcaaagaaat gacagtatgc gaaccaataa
     8521 aaccggtgcc accggtaacg agaatattca tagtttagga tttggggctg tactagataa
     8581 ctagaataaa ttctgcttta ctaattgttt taaaatgaaa atttgaactt ttatttcact
     8641 gtggttaaaa cgccattcac attccttcaa atacagttca aaatgctctt tgggaatgcc
     8701 gttaaacttc cgtaagtggc gttttgcctg attccaaaag ttctcaattc cgttaatatg
     8761 attttgtcgt tcagcaaaat gtgtgctgtg attgatgcga aagtggctaa actcactcac
     8821 atcaagtaca tcatagcttt tgtaacaatc agtataaaca atactgtcag gctttacctg
     8881 ctcacgtatt atcggtaata aagtggcagt ttgcgtattg ggcacagcaa cggtgtaaac
     8941 cttgccgttg cgtttcaaaa gcccgaatac agccactttg ccggccgcac ctcgaccgcg
     9001 tttacctttg cgctgtccgc caaaatagct ttcatcaact tctacttcgc catcaaacat
     9061 ttccagatgc gggctgttat ggaaaatcag taagtgtaaa cgatgaaaat aataggcagt
     9121 agtgttttta ttaacgccga ctaattgtgc tgctgtgcgt gcggtaacac ctgcaataaa
     9181 cagttcaatc agtttgtttt gcttgtactg acttaaacga cttcttctca tagggattat
     9241 tctaacctga aattagattt ccctagttat ctagggcgtg tcctcaattt aacttagcat
     9301 gaataataga gcaagccaag taaagcatcg atttaaaatt acgagctaat ttctcatagc
     9361 gagtagcaat actacgaaac tgctttaatc gtgcaaatgc attctcgact aagtggcgta
     9421 atttataaag gtagctatca aaatcagggt taggtttctt ggcattttta cgctttggta
     9481 taatagcttt cataccgtgt tctatcgctt tatctctgat ttcttgcgag tcataccctt
     9541 tgtcagcgat aaaatactgg gcttcttgta tgacttctat caagtcgttt gcaacttgac
     9601 cgtcgtgcac gttaccccca gtgactttaa aatcgagcgg atttccatgc gagtccacac
     9661 ataggtgtat ttttgtcgtg tttccgccac ggctttgtcc aattgctcta tcgaaaccac
     9721 gccgagctcc acttgcatgt tgatgacacc gtacataact tccgtcgatg aatacccatt
     9781 ctttgtcaat ttcttttcgt agatcaaaaa aaaattctgc cacaagcctt ttttagacca
     9841 tcggttaaag cggttataag cggttttcca tgaccctagc tcaataggta tgtctcgcca
     9901 tggtgcacct gttcttagct tccatagtat ggcttccatc acggtacggt cgttcttcca
     9961 ttgatgacag ccgtgcgctt tcatggttgt ttgtaattgt tcccatatgt tgtcagttat
    10021 tgcggttctc gccattgttt gtgtttgcct atatttcgtt ggaatatagg gttaaaatag
    10081 ggctcttttg ggcttattca aattagggac acgccctaat aaaaaacaga caaagttccc
    10141 acaatcattt gtaaaaaaaa taaattaatt taaaatattt gctaggttat gatatactaa
    10201 acgacttgaa gaattcaaaa ataaccattg gataacagaa agctatgaat gccacacaaa
    10261 aattcttagt cgtatttgga acgcgtccag aagccatcaa gatggctccg cttgttgatg
    10321 ggtttaaaaa gctcaatttt gattttaaag tttgtgttac cgcgcaacat cggcaaatgc
    10381 ttgatcaagt attgaagctc tttgagataa agcctgatta tgatttagat attatgagta
    10441 gtggacaaac tttatcagat atcacagcga ctattctgca aaagatacag cctgtaattg
    10501 agaattataa gcctacagta atttttgtac atggagatac ggcaactacc ttagctacct
    10561 ctctagctgc atattacaat caaatcgata ttgcgcacat tgaagcaggt ttgagaacag
    10621 ggaatattta ctctccgtgg ccggaagaag gtaatcgtaa attaacgggt gcattagcta
    10681 aatatcactt taccccaact cagggtacgc aagaaaacct aattaaagag catgtttcta
    10741 ttgataaaat ttatgtaaca ggcaatactg taattgatgc tttatttcta gcttctgaaa
    10801 aaatcgaaca agataaacag ttacatgaga aattacaatc agattttgaa tttttatcag
    10861 atgataaagt agtactcatt acaggacatc gaagagagaa ttttgggcaa ggcttcgaga
    10921 atatttgtaa agccatcgca aaattatcag atgataatcc aacagtacgt tttgtttacc
    10981 cagttcactt aaacccaaat gtaagagagc ccgtacaaag attattggca aataaagcta
    11041 atgttcattt gattgagcct ttagattatt tctcatttac atatttaatg aaaaagtcat
    11101 atctaatttt gaccgattct ggtggtattc aagaagaagc accttcacta ggaaaacctg
    11161 ttttggttat gagagatact acagaacggc ctgaagcagt ccaagcgggt acagtcaaat
    11221 tggttgggac gaattatgaa aaaatcgttc aagaggtcaa tacactttta agagacaagc
    11281 ttcagtatca gatgatgtca gaagctcata acccctatgg cgatggaaca tcagtagaaa
    11341 aaattcttaa ggtttttaaa tcaaattaaa ttttttagtt aaaggtatga atatgtatca
    11401 aaataaaata atttcagtta ttggtctcgg atatatcgga ttgcctacag ccgctgcatt
    11461 tgccggccat ggcgtgaagg taatcggtgt ggatgttaac cagcacgctg tagataccat
    11521 caatcaggga aaaattcaca ttgtggaacc cgacttggat attgccgtgc accaatgtgt
    11581 taccaatggc acactcaaag ctaccttagt tccagagcct gccgaagcat ttttaattgc
    11641 cgttcccacc ccttttaaag gaaacgatta cgagcctgac ttaagctaca tcgaagcagc
    11701 cagcaaagcc attgcgccgg ttttgaaaaa aggcgactta gtaattttag aatctacttc
    11761 gcccgttggc gccactgaac aaatggctgc ctggttggcc tcagaacgcg cagatttaag
    11821 ctttcctcaa caaaaaggtg aagattccga tattcggatt gcccactgcc ccgagcgcgt
    11881 gctccccggc caagtaatgc gcgaattgat tgaaaacgac cgtatcatag gcggcatgac
    11941 ctcgaaatgc tcggaacaag ccgtagccct gtataaaact tttgtaaaag gcgactgtat
    12001 tattaccaat gcccgcacag ccgaaatgtg caaactaacc gaaaactctt tccgcgacgt
    12061 aaacatcgcc tttgccaacg aactttccat tatttgcgac aaactggata tcaacgtgtg
    12121 ggaattgatt tccctcgcca accgccaccc tcgtgtcaac atcctgcaac caggttgcgg
    12181 tgtagggggg cattgcattg cggttgatcc atggtttatt gttaacaaga ctcctgattt
    12241 ggcgaaactg attcataccg ctcgtttggt caatgatggt aagcctgaat gggtgattgg
    12301 taaagttgat gaagcggtta ttcaagtatt gcaaaaaaat cctactaaaa ctgtggctga
    12361 tgtcaaaatt gcgtgtttag gattggcttt taagccagat attgatgatt tgcgtgaaag
    12421 cccagcgcta aaaatcactg aaaaactggc agagaaatat ccaaatcaaa tcttggcggt
    12481 agagccaaat gtagatgaat tgccaacaaa actagccgac aaaggtatta agctcgttca
    12541 gcttgatgat gtgttagcag tagcagatgt attggtggtt ctagtggatc ataaagaatt
    12601 taagggcgag caactggttg atgttaaagg attggttgtg gatacaaagg gtcttgttta
    12661 atatttaact ctctactcgc aacttaaaat ttaacttatg gattttataa gggcgtatca
    12721 tcttgccttt ataaaaatcc ataagttata caaagttaag aatagggtat ttgatagaaa
    12781 tctagttgaa aaaaagctat acggtgtcgc aaatgctaaa aaaattcaga aaaaatgcta
    12841 caaaaacagt taattcgtta aaaaagcata aaattattca acaaatctca tctgcaaacg
    12901 agaagagaat tgcaaaattt tttgatttgt atttaaaaga taagtcggta ccatatcaat
    12961 tacctcatca taaaagcgaa agagagtctc tgattcttaa tacttatctt tcaaatggta
    13021 ttaatggtct tattggcata cttgagaaag atcaaaccaa ctccaaaatg gaaaggtcta
    13081 aggtttattt agaggcaggt caaattgtta aaaagcataa caaatatgat gcatatttgt
    13141 tatgctatat ggcaaatggt ttatacaaat ctgagacaac atgtcgagct ttggggtggg
    13201 ctgcgctgca tgcaaaagag ctagagattg ctcaaatgtg tgtgcaggag cttgatgaat
    13261 tttatcaaaa agagggggat gtacagcaca agaaactggc tgagcgttta aagttgtctg
    13321 taagcaaggc ggtggaagta ttgcggggtg atgcaataaa agcttcaagc attaaaatat
    13381 catataagca agatgaggta gtgtctgaaa cttttgaaga acaccgagta gatgttgaat
    13441 ttcttctagc gttatacaaa caatcaacac gagagaaagt tgtggctgta attcaaaaca
    13501 gtgaattgaa acaaaaagaa aaagctcagc tttgcattca gctgagtaag cattttcgtg
    13561 aattattcaa aattgaacaa tctgtttact ttgcagatca agcactattc tttgatgaaa
    13621 gtgctaccat acttagaggt gtgtattggg catacaagcg cgcaggtgag caaagtaaaa
    13681 ctgataatgt tctaaaaaaa ttagaacaga atatgcttac gctttcacgg aaagaacaag
    13741 atgctatcaa aaagctgaga gcaaactaca atagtactta tagcgtattg aaagtgctag
    13801 aagacttaaa atctgtaaga aagcaatatc cagagcatgc ccctattaaa aataggattt
    13861 gctatgtatt acataatagt ttgccttatg cttcaggagg gtatgcaaca agagggcatg
    13921 gtttggcaaa aggatttcta aatcatggtt ttgatatcaa agttgtgaat agacctggct
    13981 tcccttatga aacaaagccg gagttggatg agttgcaccc cccgaaatta gagcaagtcg
    14041 atggagttga ctacattaaa atatctcaac caagaagagg ggttggatta acgacagctg
    14101 attatattgg acaggcaacc gaagcattgt tgcaagagtt tttggaatta aaacctgaaa
    14161 ttattattgg tgcatcaaat tatttgactg cattaccagc gttattagcg gcaagaaaat
    14221 tgggaattcc ttttatttat gaagttcggg gtttttggga aattaccaga ctttcaagag
    14281 agcctgagtt tgcacaccat ccaagtttta aaattcaagt tgaaatggaa tcagctgttg
    14341 ttaaagccgc tgatcatgtt ttcacattaa ctaatgcaat gaaagatgaa ttggttaagc
    14401 gaggggctga tatatctaaa attacactaa ttcctaactc ttgcaatcca gagcaattta
    14461 tcccaagaac taaagatgtt gccctgatgc aaaagctaag tttccctgaa aatatccctg
    14521 ttataggata cataggaact tttgttattt atgaagggct agaatattta gctgaagctt
    14581 gcggtaaact aaagcagcgt ggcattgagt ttcgcctgtt attagtagga aatgaaaata
    14641 ctgcaggaac aaatcgtggt gaaatcacag aaatgattgc tcaaactgtg gaaaaatatg
    14701 gttttacgga ctggttagta atgcctgggc gaattccttt taaagaagta gaatcttatt
    14761 actctattat tgatattgtc ccctttcctc gcaaaccctg gcctgtatgc gaaatggtat
    14821 ctcccatgaa accactagaa gcacttgcaa tggaaaaagc tattgttgta tctagtgttg
    14881 gtgcattagc tgagatggta aaccctaatg aaactggggt tgtatttaga aaaggcgata
    14941 ttgatgacct tgctgataaa ttacaaatgc taatttccaa tcctgactta tgcaaaataa
    15001 tgggtaaaaa tggacgcatg tgggttgagc atgaaagaac ttggcagaag acatcggata
    15061 aagcatcgtc tatgctaaaa ctggtattgg atggtaagta aatatcacgg tttgaaaaat
    15121 aaggattaat atggacttaa ctcaatcttg ggatctgata cctcttaatg gattcttata
    15181 tagaatcttt cttgtggatt cgcagaccat tgatgagatt atagaaaaac gtagttttaa
    15241 gcctaggaaa gattgtgata acttctttct tgttgaacca attgattggg aagcaacaca
    15301 caaaccatca gatagaaact ggaggatgca gttacaagga tggtttttct tgaatcctat
    15361 tatgaatggc ttcgattctt atcctgataa ggataggttg gttcagtttt ttcttgatct
    15421 tgctttgagc tggtgggata agtataaaaa tgatgcagat gatattgtca caagtagaat
    15481 gccaagtagt tatgcttggt atgatatgtc agtaggttca agagccttgt gtcttgcttt
    15541 ttttcaaaat cgaattaagg tttatggact tgacatcagc gaacaaaata aaaaagttat
    15601 ccacgagatg gcacaaaagc atattcgtca tttaagcaat aaggcagtat ttagtttaaa
    15661 taatcacggt atttttcaag ctcatggttt gatggctctt gcccatgttt ttgaatctaa
    15721 ggcctccata aaagagtatg ccactgaatt ggtcaaaaga ttgttagaca accaatttga
    15781 tgaaaatgga attcatttag aacacagccc tcattatcat ttctacgcat taagtgcatt
    15841 tcgtgcattg ctaagatctg aattatataa agaatcacaa gactttaatc aaaaaattca
    15901 gaaggctgaa gataaatgta aatggttgat tgatccatta aagcgtccga tttgtgttgg
    15961 tgactctatt ttgacaactc aaaatagagt gatgtttccg acgtcagact cacaagattt
    16021 cttgattagt gatttttgtg aatctggata ctctgtagtg aggtctccat ggtctacctc
    16081 acctgagctg gcgtcaatga ttttttttgc cggtgcatat cattcaaaaa gtcataagca
    16141 tagagactgt ttaacttttg attggtttga acaaggaagg cgtatcattg cagattcggg
    16201 aaaatatgga tacaaaagtg ataagtatag aaattatttt ttatctaata aagctcacaa
    16261 cagtgtagag atcgagggtt ttgatattct taaaataaaa ccttatggct cggctgtgtc
    16321 caatccaaaa aaaatagctg atgatatata tcaattaaac ggtaccttag actacccagc
    16381 aattaaacat aatagaaccc ttacctatag acctttaagt tgggttattg ttgaagacat
    16441 tctagatttt gcaagagagc gccatgcaac acaatggttt catttggaga atgattttaa
    16501 tcttgtatct agtgctgaaa atcaactttg ttttcagcgt gcaaatgaag agttgcatat
    16561 ccattgcctg gatgaagatt taaatctttt attacattat ggtgacgaag tttccatgca
    16621 aggttttttg tcgcaaaaag acttcatgtt tgattcagct tatgcgattg ggtttaaagg
    16681 aaagtttaag caaaaaagaa ttttgactat actagcacgt agtatggcgg atttagataa
    16741 tgccaaggag tttcttggtg tcaaacagcc tgatgttagc ctgcccaatt ctccgctgac
    16801 accccaaatt ataaaaggag agcgacatct tgcattatca gaaatgaatg agctaaaaag
    16861 gaatcacctt gataataaag gcacatttca agtggtatca gataatgtga catttacttt
    16921 ttttggtaat ttttttcaag ataaaaaaaa gaaaatagtg ttcttcttcc ctggtgcaac
    16981 caatagaagt aaaagcaaat ttgatatgca gcgtttttca tggtcttctg aactgaatga
    17041 tgttgaaaca gtattttttg cagatcctac atacaaacca aataatgatt tgtcaattgg
    17101 ctggtttcag catacttata aagattttgg cattgatgca ttggaaaaat taatcaggca
    17161 tattactgcc ttaaaaggtt atgctcaaga tgagatggta ttttttggat cctctgcagg
    17221 tgggtttgtt tcattaaaat tagccgagag gtttgataag tctgatgcta tctgtattaa
    17281 tccacagatt tatttgccaa aatactctag agacttttat caacatttat tgagcgtgtg
    17341 ttatcctggt ctaagtgagc aagaagtttt ggagagattt ggtgatagaa ttgcagtcac
    17401 taaagatctt tcacaaaata caggtagaat tattattttt caaaaccaat atgatgaaaa
    17461 tcatatgaaa aatcacatag gatattatct aaagaatcat aatttaataa attgtagatt
    17521 atcttttgaa aattattcac ccgagaatgt tgaaaatgga ttatctgtag taatttacca
    17581 agatgaaaaa ttaggacatt ctcctcctag caaagagata actcttcaat ggattcaaga
    17641 cttgttgtga ttttgcaatt caggttatat gaatgttgga tcaatgaaac tctacctaat
    17701 cagcgacaac cttacccatc aatccctgct cttggagaat atcgatcttc aagagtcttg
    17761 gtggtggttg cgtaaagcaa acaagccgat tttatttgta gaatcggctt ggaatggtta
    17821 tcaggacaga tgggaatttc aaatcgctgc ctatcctgat tatcctgagc gtaataatca
    17881 aaaactgatt aaattgctag aaaaagcaaa gtcaaaaggt attccgacgg ttttttggaa
    17941 taaagaagat tcggtgcatt ttgatcgttt tattgattct gctaagcatt ttgatcatat
    18001 ttttactgtg gatgaaaatt gtgtggaacg gtatcgggcg gttgtgccgg cttcaatcac
    18061 ggttgatgtg gcgatgtttc ccgtccagcc ccgtattcat aactatcagg ggtttaactt
    18121 tcagcaattg gaagcgaatt ttgtcggcag tttcagcagg catatccacg acaagcgccg
    18181 cgagcgtcaa gaaatgttgt tttctgctgc cttgaaagca ggcttgccgg ttacgatttt
    18241 cgatcgtaat tcagacagaa aatcagataa ctaccgttat cctgagcagg aatttggcct
    18301 gaaaatcatg ccggctttag attatgccca aaccgccgat atctaccgtc gttttgcggt
    18361 ttcattgaat gtcaatacga ttgaagattc gcccactatg ttttcacggc gggtggtgga
    18421 aatcttggct tgcggcggta ttttggtttc cacgcccggc atggcaatgg acaggttgtt
    18481 taaagattat tgccatatcg taaacaatga agatgaagcg gtggctttgt ttgagcgttt
    18541 gaaatacggg ccgtctgaaa gagatttgga aatggccaag gcaggggcgg attttgtatt
    18601 aaataacttc acttggcaga agtttttaga aaaaatacaa tcagttgtat tttgatatat
    18661 gctgattttt taaattaggt atatttaatt gagtataatg gctaaatttt ttattttaaa
    18721 ggctgggaat atgaataaac tgtttggaaa gccttttttg gctttgatga ctgggatgct
    18781 tttggttggg tgcggggcat taccttcctc cggcccaagt gcaaaaaaag ttgtctcgtt
    18841 aggccaacag tctgaaactc aaattcctga agtggagttg attgatgtca accatgccgt
    18901 ggcacagtcg ctgtataagg ctcaggtgaa tcagtcgttt actcagtttg gtgatggtta
    18961 tgcttctgcc ggtacgctga atgtcggtga tgtattggat attatgattt gggaagcgcc
    19021 gcctgctgtt ttgtttggcg gtgttctttc ttcgatgggc tcgggtagtg cgcatcaaac
    19081 caagttgcca gagcagttgg tcacggcacg tggtacggtt tctgtgccgt ttgttggcga
    19141 tatttcggtg gtcggtaaaa cgccgggtca ggttcaggaa attatcaaag gccgtctgaa
    19201 gaaaatggcc aatcagccgc aagtgatggt gcgtttggtg caaaataatg cggcaaatgt
    19261 gtcggtgatt cgtgcaggca atagtgtgcg tatgccgttg acggcagccg gtgagcgtgt
    19321 gttggatgcg gtggctgcgg taggtggttc aacggcaaat gtgcaggata cgaatgtgca
    19381 gctgacacgt ggcaatgtag tacgaactgt tgccttggaa gatttagttg caaatccgcg
    19441 acaaaatatt ttgctgcgtc gcggtgatgt ggttaccatg attaccaatc cctatacctt
    19501 tacgtctatg ggtgcggtgg ggagaacaca agaaatcggt ttttcagcca gaggcttatc
    19561 gctttctgaa gccattggcc gtatgggcgg tttgcaagat cgccgttctg atgcgcgtgg
    19621 tgtgtttgtg ttccgctata cgccattggt ggaattgccg gcagaacgtc aggataaatg
    19681 gattgctcaa ggttatggca gtgaggcaga gattccaacg gtatatcgtg tgaatatggc
    19741 tgatgcgcat tcgctatttt ctatgcagcg ctttcctgtg aagaataaag atgtattgta
    19801 tgtgtcgaat gcgccgttgg ctgaagtgca gaaattcttg tcgtttgtgt tctcgccggt
    19861 taccagtggc gtgaacagta ttaataattt aactaattaa tgtgagtaag taagatgtct
    19921 gagcaacttc ctgtggcagt tgccactgaa accaaagccg agcgtaaaaa gccgaaaaag
    19981 aaaagttgga ttaaaaagct aagcccttta ttttgggtaa cggtgattat ccctacggta
    20041 atttcgttgg tgtatttcgg cttcttcgct tccgatcgtt ttacgtcgca atcgagcttt
    20101 gtggtgcgct cgcctaaaag ccaatcttct ctcaatggcc tgggtgccat tttgcagggc
    20161 acaggttttg cccgtgcgca agatgatatt tacacggttg gggagtatat gcgttcgcgc
    20221 tcgtctttgg atgaactgcg taaaatcttg ccggtgcgtg agttttatga aaccaaaggt
    20281 gatgcgttca gccgctttaa tgggtttggg ttccgtggcg aggaagaggc tttttatcaa
    20341 tactataaaa atcaggtgat gatcaatttt gatacggttt cgggtatttc cacgttgaat
    20401 gtaacttcct ttgatgcgct ggaatctaag aaaatcaatg aggctttgtt aaaacaaggt
    20461 gaagcattga ttaaccagtt gaacgatcgt gcacgtgctg atacggtgcg ctatgcggaa
    20521 gaagtagtga aaacggcggc agagcgggta aaggaagcct ctcagaatct gacggattac
    20581 cggattgcca atggcgtttt tgatttgaaa gcgcaatcgg aagtgcaaat ggggttggtt
    20641 tccaagctgc aagatgaatt gattgtgatt caaacccagc tggatcaggt gaaagcagtc
    20701 actccggaga atccgcagat tccgggtttg caggcgcgtg agcagagctt gcgtaaagaa
    20761 attgaccaac agttacgtgc catttcgggc ggtgggcatt cttcgttgtc taatcaggct
    20821 gccgaatatc agcgtgtgta tttggaaaac cagttggcag agcagcagtt ggcagccgcc
    20881 atgacttctt tggaaagtgc caaggttgaa gcagaccgtc agcagcttta tttggaagtg
    20941 atctcgcaac cgagcctgcc ggatttggca catgagccta aacggttata caacattgtt
    21001 gccactctga ttatcggctt gatggtttat ggtattttga gcctgttgac tgccagcatt
    21061 cgtgagcata aaaactgatg aaagccttgc ataaaacatc attttgggaa tctttagcca
    21121 ttcaaaggcg cgtaatcggt gcgcttttga tgcgggaaat tatcacccgt tacggtcgca
    21181 ataatattgg ctttttatgg ctgtttgttg agccgttgct gatgacattc gttatcgtct
    21241 tgatgtggaa atttttaaag gcagaccgat attcaacttt gaatattgtc gcatttgcga
    21301 ttactggcta tccgatgttg atgatgtggc gtaatgcctc aaaacgggca gttgggtcga
    21361 tttcttcaaa tgccagcttg ctttatcacc gcaatgtaag agttttggat accatcttgg
    21421 cgcgcatgat tttggaaatt gctggtgcaa ccattgcgca gattgtgatt atggcggtat
    21481 tgattgcgat tggctggatt gaaatgccgg cagatatgtt ttatatgctg atggcttggc
    21541 ttttgatggc tttttttgcg attggtttgg gtttggtgat ttgttcgatt gcctttaatt
    21601 tcgagccgtt tggcaagatt tggggcacat tgacttttgt gatgatgccg ttatcgggtg
    21661 cattcttttt tgtacataat ttgcctccga aagtgcaaga gtatgcattg atgatcccga
    21721 tggtgcatgg cacagaaatg ttccgtgccg gatattttgg cagcgatgta attacctatg
    21781 aaaatccttg gtatatcgta ttgtgcaatc tggtgttgtt gttgtttggc ttggcgatgg
    21841 tcagtaaatt cagtaaagga gtcgagccgc aatgatttcg gttgaacatg tttccaagca
    21901 gtatcaaatg cgcggcggta tgcggacggt gttagacgat atcaattttt cgctgcaaaa
    21961 gggtgagaaa gttggtattt tgggtcgaaa cggtgcaggt aaatcgacgt tgatccgttt
    22021 gattagtggt gtcgagccgc ctacctcggg cgaaatcaag cgaaccatga gtatttcttg
    22081 gccgctggcg ttttctggtg ccttccaagg aagcctgacc gggatggata atctgcgttt
    22141 tatctgccgg atttataatg tcgatatcga ttatgtgaaa gcgtttacgg aagaattttc
    22201 ggagctgggg caatatttgt atgagccggt gaaacgctat tcttcaggta tgaaagcgcg
    22261 tttggctttt gcgctgtcgt tggcggtgga gtttgactgt tacctgattg acgaagtgat
    22321 tgcagttggt gactcgcgtt ttgccgataa atgtaagtac gagttgtttg aaaagcgcaa
    22381 agaccgttcc atcatcttgg tgtcgcacag ccacagcgcc atgaagcaat attgcgataa
    22441 tgcgatggtg ctggaaaaag ggcatatgta ccagtttgaa gatatggaca aagcctacga
    22501 atattataat tcgctgcctt aaagcgattg tttttaaatc aggccgtctg aaatttcaga
    22561 cggcctgtcc gttggaattc tattgatgaa cattactcaa attctttccc aagaactctc
    22621 cgcgactgcc gcgcaaatca ccgccgccgt cgagcttttg gacgacggcg cgaccgtgcc
    22681 gtttatcgcc cgctaccgca aggaagcgac gggcgggttg gacgatacgc agttgcgccg
    22741 gcttgccgag cggctgcaat atctgcgcga gttggaagag cgcaaagccg ttgttttaaa
    22801 aagcattgaa gagcaaggca agctttcaga cgacctcagg gcgcaaatcg aagccgccga
    22861 taacaaaacc gcgctggaag acctgtatct gccctacaaa cccaaacgcc gcaccaaagc
    22921 gcaaatcgcg cgcgaacacg gtttgcagcc gctggcggac gtgttgcttg ccgagcagtc
    22981 gcaggacgtg gaagccgccg cacaaggcta cctgaacgaa aacgtccccg atgccaaagc
    23041 cgcgttggac ggcgcgcgtg cgattctgat ggagcagttt gccgaagacg cggaactcat
    23101 cggcacgctg cgcgacaagc tgtggaacga agccgaaatc cacgcgcaag ttgttggagg
    23161 caaagaaacc gaaggcgaaa aattcagcga ttattttgac caccgcgaac ctattcgtgc
    23221 gatgcccagc catcgtgcgc tagcggtttt gcgcggacgc aacgaaggcg tgttgaacat
    23281 cgcgctcaaa tatcagcccg acgacacgcc gattacgcag caaagcgaat acgagcaaat
    23341 catcgcccgc cgcttcaaag tttcagacgg ccacaaatgg ctgcgcgaca ccgtgcgcct
    23401 gacttggcgc gcgaaaatct ttttgtcgtt ggaacttgaa gctctcaatc gtttgaaaga
    23461 agccgccgac accgacgcga ttaccgtgtt cgcccgcaat ctcaaagact tgctgcttgc
    23521 tgcgcccgcc ggacggctga ccacgctggg tctcgacccc ggctaccgca acggcgtgaa
    23581 atgcgccgtg gtggacgaca ccggcaagct gctggatacc gtcatcgtct atttgcatca
    23641 agaaaacaat atgttggcaa cgctgtcgcg cctgattaaa cagcacggcg tgaagctcat
    23701 cgccatcggt aacggcaccg ccagccgtga aaccgacaaa atcgcgggcg aactggtgcg
    23761 tgaaatgtcg aaaatggggc tgcataaaat cgtcgtgtcc gaagccggcg cgtcgattta
    23821 ttccgcgtcc gaactggcgg cgcgcgagtt ccccgacttg gacgtttccc tgcgcggcgc
    23881 ggtgtccatc gcccgcaggc tacaagaccc gcttgccgag ttggtcaaaa tcgaccccaa
    23941 atccatcggc gtggggcagt atcagcacga cgtgaaccaa agccagctcg ccaaatcgct
    24001 ggacgcggtg gtcgaagact gcgtgaacgc cgtcggcgtg gacgtgaaca ccgcctccgc
    24061 cccgctcttg gcgcgaattt ctggtttgaa tcaaaccctt gcccaaaaca tcgttgccta
    24121 ccgcgatgaa aacggcgcgt tcgacagccg caaaaaattg ctgaaagtac cgcgtttggg
    24181 cgaaaaaacc ttcgagcagg cggcaggctt tttgcggatt aacggcggta aagagccgtt
    24241 ggacgcgagc gccgtccacc ccgaagccta tcccgtcgtc gccaaaatgc tggcgcaaca
    24301 aggcattagc gccgccgaac tcatcggcaa ccgcgagcgc gtgaagcaaa tcaaagtgtc
    24361 cgacttcacc gacgaacgct tcggcctgcc gaccattttg gacatcctgt ccgaactgga
    24421 aaaacccggc cgtgatccgc gcggcgagtt tcagacggca tcgtttgccg aaggtatcca
    24481 cgaaatcagc gacttgcaag tcggtatgat actcgaaggc gtggtttcca acgtcgccaa
    24541 cttcggcgcg ttcgtggaca tcggcgtcca tcaggacggc ttggtgcaca tctccgccct
    24601 gtccaacaag ttcgtccaag acccgcgcga agtggtgaaa gctggcgacg tggtgaaagt
    24661 gaaagtgctg gaagtc
//

