LOCUS       MH444268               22644 bp    DNA     linear   BCT 18-AUG-2018
DEFINITION  Providencia alcalifaciens serogroup O46 antigen biosynthesis gene
            cluster, complete sequence.
ACCESSION   MH444268
VERSION     MH444268.1
KEYWORDS    .
SOURCE      Providencia alcalifaciens
  ORGANISM  Providencia alcalifaciens
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Providencia.
REFERENCE   1  (bases 1 to 22644)
  AUTHORS   Du,Y. and Liu,B.
  TITLE     Development of a Molecular Serotyping Scheme and a Multiplexed
            Luminex-Based Array for Providencia
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 22644)
  AUTHORS   Du,Y. and Liu,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2018) Teda Institute of Biological Sciences and
            Biotechnology, Nankai University, 23 Hongda street, TEDA, Tianjin,
            Tianjin 300457, China
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: Velvet Optimiser v. v2.2
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..22644
                     /organism="Providencia alcalifaciens"
                     /mol_type="genomic DNA"
                     /isolation_source="human urinary tract"
                     /host="Homo sapiens"
                     /db_xref="taxon:126385"
                     /country="Poland"
                     /note="serogroup: O46"
     gene            1..1257
                     /gene="cpxA"
     CDS             1..1257
                     /gene="cpxA"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor protein"
                     /protein_id="AXL96459.1"
                     /translation="MESEQRQGEMLEQHIEAELAQAPMNDLLWWRRISNAIKKWAPPG
                     QRLIIVTSEGRVIGAMPSEMQVIRNFIGQSDNADHPKKKKYGRAEILGPFSIRDGEDH
                     YQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAAD
                     DVAKGNLRPHPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTR
                     LQLATALLRRRHGESKELERIETETHRLDSMINDLLVLSRSQHKNEILREHIKADELW
                     GDILDDASFEAEQMNKTLDVTSHPGSWPLYCNPSAIGSAFENIVRNALRYSNTHIAVD
                     FKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQ
                     HKGWVKADDSPLGGLRLQIWLPEHGR"
     misc_feature    1..22644
                     /note="antigen biosynthesis gene cluster"
     gene            2085..3377
                     /gene="wzx"
     CDS             2085..3377
                     /gene="wzx"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="AXL96460.1"
                     /translation="MQNILSKLKNNPNIYKIISNSSWLLFDKFTRMGLGLLVSVWIAR
                     YLGPSQYGELAYVLAYLAFFQSISTLGMDSLIVRDIAKNKNIANEVLGTAFTLRASTG
                     LICWILAIIGMGLLNGWHSQSIYITALAGATLVFQSADTVDLWFQSQSQNKRTVIVKL
                     SAYIIANGIKVILILNEAPLLAFAAVITFETSAIACGLFYAYRKFPCSNLWNRTKQRA
                     ITLLHESWPFMVSGLSIVLYMRVDQLMIKNYLGDVELGIYAAVLPLAALWQFLPMTLS
                     VSLAPMVAQSKAQGDDQFYKTLGYIFRVFAILGWLVCIPISILSYFIVNILFGETYIA
                     GASVLSIIIFTNLFINMGVAQSLWIVNERKSKLSLYKTLMGAVVCVTANIILIPYYGI
                     IGAAISAVLAQAVSAMLSNIILSKKILYLQCKSLLLIK"
     gene            3391..4299
                     /gene="gt1"
     CDS             3391..4299
                     /gene="gt1"
                     /note="GT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AXL96461.1"
                     /translation="MNQPNLAPVVLFVYGRPIHTQRTIDALLKNPESKDTDLIIYSDG
                     PKQHNDTEKVESVREIIKKTSGFKSINLIERTENLGLAANIIDGVTKVCEEYGKVIVL
                     EDDIVTSPFFLNFMNSALNKYQSNEKVWHISGWNYPLKNTEELPETFFWRTMNCWGWA
                     TWKDRWQYFEKDPSKLITTWNKDAIKRFNLDGIYNFWSQVEVNMNGKLNTWAIFWYAT
                     IFSHNGLCLNPTKSFVANIGNDGSGENCGNSDIYKSELSHNPIIEWPNIFLENSHAVN
                     YIKFFYKKNQPSYMRRILSKIKRGIL"
     gene            4296..5591
                     /gene="gt2"
     CDS             4296..5591
                     /gene="gt2"
                     /note="GT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AXL96462.1"
                     /translation="MKVLHLSHSDIIGGAARASYRLHKALLKSDIDSKIMVRIKKSDD
                     WTIQGPKSHISXXXXXXXXXGPKSHISKLTNTFRATLGRALTNLQHSENMNLHSCNWL
                     TSSWAKKINATDADLVHIHWIGNETLSIKDIGKIEKPIIWTMHDMWPFCGTEHYAEDQ
                     IDSRWTTGYTQKNRIQGDYRLDIDKLIWNRKIKAWKNTNMNIISPSKWLADCARKSIL
                     FRNSNINVIPNPLDTQTYKPFDTSFCREILRLPQNKNIILFGAISGGNDPRKGYNLLI
                     DSLHKLKYKVDSSSTICVIFGQSKPKNVPELPFPTYWLGHLNDDPTLSLLYNSATVMV
                     VPSTQEAFGQTASEAQACGKPVVAFSTTGLLDIVEHKKTGYLAKPFDTQDMADGLCWI
                     LNDKIAYSELCINARKRALELWADDIVTNSYLDIYKKII"
     gene            5657..6907
                     /gene="wzy"
     CDS             5657..6907
                     /gene="wzy"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="AXL96463.1"
                     /translation="MTILLSSIQFSIVLFLLLSSKFKTGNSLTLIPCMAMIWLVHSIL
                     ANSGYTGFYPLSEKANLLITLYLLGYAFSFCIFNQTSNKYGLLVFEFRKIIIEKLIIN
                     LSLILTIFLSIVVLIYSIIASIDLQSLRDIIYSSDNPYSAIISPIIWIVTGLFFYLFL
                     FSFYAYFSGKIPKWYVIASILNIILFNLSSGGRTSIIYLLILLASSWILIRKNIPRPF
                     NIIKINATIKKGLYSIIIVIISITVIRSGGDITSIYYTYNKYFIGSFVAMSEFIDVYN
                     LELQNVRFGYSLMGLDTFTVSGLCRFIFNIDIPSILSQVSGAMHHGVYISNDIVTNAH
                     YTILTSFYWDYGYAGAFLIGFLSCSLFIIFHNKFYRTLSFGYFTLTIFMILLIVYSIR
                     TNILLEPQFFIMFIFIFIRTKLAR"
     gene            6911..7693
                     /gene="gt3"
     CDS             6911..7693
                     /gene="gt3"
                     /note="GT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AXL96464.1"
                     /translation="MFSIVTINYNNHDGLKNTFDSMKSQTISKELYEFIVIDGNSTDS
                     SKKLISDNSEYIDKVIIENDNGIFDAMNKGISLADKKYIFFLNSGDQFDNPSVLTDMY
                     AIIKSNPNRNLYKGRVNTFIDGTFLREAELCPWVCHQAVFLKTELSKKYLFDTNLKIF
                     GDLDLWYRLKADGLYSIFETNILICNMEMDGVGNSPLFIRKRIQDKIIFNNKHNLSTR
                     LYIDRIIQYTSYIFFKLFGKKAYHKYYIGSLIYVRKKIHSSI"
     gene            7662..8237
                     /gene="at"
     CDS             7662..8237
                     /gene="at"
                     /note="AT"
                     /codon_start=1
                     /transl_table=11
                     /product="transferase"
                     /protein_id="AXL96465.1"
                     /translation="MLEKKYTQAFKKILTNPGFAYFKLKKIISSIIKSPFNFLFFKKF
                     GRFSYISYHASIINKPKITVGSFVEINRGCCIWPLSLDIANGVQINPNTVIYGVVSIG
                     ENTMIGPNCNIIGGNHNFANTHVPMKYQGSTEKGIKIGNDVWIGAGVTILDGVTIGSG
                     SIIGAGSIVTKDLPPFSISVGNPIRIIKIRT"
     gene            8234..9277
                     /gene="gt4"
     CDS             8234..9277
                     /gene="gt4"
                     /note="GT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AXL96466.1"
                     /translation="MNIIFQPYYYWTGHFKQYADSLLGSDDILIKSKKNKKYSGFISY
                     CYFRFYYFTISLFKLIKYKKKINNIFILDFEPISILLFNRLIFKKEIQYIITIHAIEK
                     NDYKSTFKNKVAQFQRFALKSALATINKKFNCKFVVHTHAHQTQLIDFLKTEHLNINV
                     IEYPAPQPASSPNSLVKSFNIYPKSLLVFGAIRADKGLYEFIESIRKANLDESIEIIF
                     AGKVMDDRFDSYIPPKNVKIINKFLTEPELHNLVQNCHFFLVPYAKNYTGGAGPAKDA
                     TSYGKPIITSNLAIFNEFSKNSFVYTINDANDLNNIINNITDTEYDASCVASLEYSKL
                     NNWSTFRNKYISL"
     gene            9338..10444
                     /gene="gmd"
     CDS             9338..10444
                     /gene="gmd"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="AXL96467.1"
                     /translation="MKKALITGITGQDGSYLAEFLLEKGYQVHGLIRRASSFNTERID
                     SVVNNSDSIKLHYGDLTDTSNLIRLVKEIEPDEIYNLGAMSHVAVSFESPEYTADVDA
                     IGTLRLLEAIRINGLEKKTRFYQASTSELYGEVQEIPQRETTPFHPRSPYAVAKMYAY
                     WITVNYRESYGMYACNGTLFNHESPRRGETFVTRKITRTIANISQGLESCLYLGNMDA
                     LRDWGHAKDYVRMQWMMLQQEQADDFVIATGKQISVREFVRMSAKEAGIELLFTGEGV
                     DEIATVTNVDKSIAPHVNVGDIIVRVSPKFFRPAEVETLLGDPSKAKEKLGWVPEITV
                     EEMCAEMVASDVQKAKQHALLKANGFDVSISLEN"
     gene            10455..11417
                     /gene="fcl"
     CDS             10455..11417
                     /gene="fcl"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-L-fucose synthetase"
                     /protein_id="AXL96468.1"
                     /translation="MKKRVFVAGHNGMVGSAIVRQLANRSDIELITKSRNELDLTNQA
                     DVDNFFAHNEIDEVYLAAAKVGGIHANNTYPADFIYQNLIMECNIINAAHKNNVQHLL
                     FLGSSCIYPKLASQPMSEHALLTGVLEATNEPYAIAKIAGIKLCESYNRQYGRDYRSV
                     MPTNLYGENDNFHPENSHVIPALMRRFHEAKLNNDEQVIVWGTGTPMREFLHVDDMAA
                     ASVYVMELDIKTYQDNTQPMLSHINVGTGVDCTIREMAETIAKVVGFAGKVVFDSSKP
                     DGTPRKLMDVSRLKDLGWSYSIELEDGLDKTYQWFLQNQNNFRK"
     gene            11430..11906
                     /gene="gmm"
     CDS             11430..11906
                     /gene="gmm"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosyl hydrolase NudD"
                     /protein_id="AXL96469.1"
                     /translation="MTQRLELNTFKTVVASTPLVSIDLIVCNSNNQALLGLRNNRPAQ
                     GYWFVPGGRICKDETFDDAFCRLTHAELGFSYDINESIFIGHYQHLYADNFSEDNFST
                     HYVVLGYLIKQDIDLNTLPLEQHNNYKWWDINELLASSEVHDNTKAYFLSHHFNSR"
     gene            11913..13319
                     /gene="manC"
     CDS             11913..13319
                     /gene="manC"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="AXL96470.1"
                     /translation="MLLPVIMAGGSGSRLWPLSRSLYPKQFISLTSKKTMLQETIARL
                     KNIEHQPPLLICNEEHRFIVAEQLRQENFKHSGIILEPVGRNTGPAIALAAIKAMQNG
                     DNPLLLVLAADHVIQDHASFTKSIEKAITSAEQGALITFGIVPTAPETGYGYIKKGNL
                     VNESAFQVERFVEKPNVNTAEQYIASNQYLWNSGMFLFKASCYINELKKHAPEILSSC
                     ELALQNSLSDLDFTRINAEIFEACPEDSIDYAVMEKADNVLVVPMDAGWSDVGSFSSL
                     WEVSPKDQQSNVIIGDVLTENTKNSYVYSQSKLVSTVGVDNLVIIETKDAVLVANKDN
                     VQDVKSIVNQLKQAGRSECEQHREAYRPWGTHDEIAQGERFHVKHLKVKPGEKTALQM
                     HYHRAEHWVVVQGTAKVTNGDKSYILSENESTYIPIGSPHRIENPGKIDLHLIEVRSG
                     NYLEEDDIVRIKEYGLDD"
     gene            13361..14827
                     /gene="manB"
     CDS             13361..14827
                     /gene="manB"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="AXL96471.1"
                     /translation="MTNHLDILNDDMIMNSYDVIKKSGIQFGTSGARGLVTQFTHEAC
                     AAFTHAFLASIKSKFNFRQVAIAIDNRPSSEFIAAACIDAIQKQGFEPLFYGVIPTPA
                     LAYAAMQSNIPCIMVTGSHIPFDRNGLKFYRPDGEITKADELEILNSNVEFELSPILA
                     PLLPVNTLATEQYIQRYCSIFDEKLLTGKRIGIYEHSSAGRDIYPVLFKKLGAEVISL
                     ERSDVFVPIDTEAVSEEDKIRAQNWSKLHGFDAIFSTDGDGDRPLVADENGVWLRGDI
                     LGLLCSLEMGIEALAIPVSCNTIISKAEQFKCVKQTKIGSPYVIEEFTNLAQDHSKIA
                     GFEANGGFLLGSDVLVNNKPLAALPTRDAVLPFLMLLSAAKKVGIASLVNSLPQRITF
                     SDRIQNFATEKSKSIIEKATSNPDKLLSNLGFSDARILEVNTIDGLRMTLSNGNIIHL
                     RSSGNAPELRCYAEANSAEIAQSTVIQVLRKIQTFSDF"
     gene            14842..15576
                     /gene="ugd"
     CDS             14842..15576
                     /gene="ugd"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="AXL96472.1"
                     /translation="MKIAIAGTGYVGLSNAMLLSQHHEVVAVDIIPEKVAMLNNKQSP
                     IIDTEIEQFLTEKQLNFRATEDKVEAYTGAQYVIVATPTDYDPKTNYFNTNSVESVIH
                     DVNKLNPEATIIVKSTIPVGFTERLREEFGYTNVIFSPEFLREGRALWDNLYPSRIVV
                     GERSERAQIFADLLLEGAIKKDVPVLFTDGTEAEXHPVSWWVSAQNAHRFSLTCCWKA
                     RLKKMCRCCLLTGLKPKRLNYSPTPS"
     gene            15579..16130
                     /gene="orf15"
     CDS             15579..16130
                     /gene="orf15"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AXL96473.1"
                     /translation="MRVAYFNELDTYAESRGLNARQIIEGVSLDPRIGSHYNNPSFGY
                     GGYCLPKDTKQLLANYDDVPNNLINAIVESNRTRKDFISDAIIAKAPRKVGVYRLVMK
                     AGSDNFRASAVQGVMKRIKAKGIEVVVYEPVLKDDEFFRSKVIRDLDAFKAESDIILA
                     NRMVPELDDVADKVYTRDLFGND"
     gene            16132..16878
                     /gene="gt5"
     CDS             16132..16878
                     /gene="gt5"
                     /note="GT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AXL96474.1"
                     /translation="MVTTENNKLVSIIMPCYNSERFIVESINSVLDQSYKFFELIIVN
                     DASTDNSVNLISSYKDSRIVLINLEKNEGVSSARNKGLSIAKGDYIAFIDSDDIWISN
                     KLEKQIELLNKDWDVICSNYSTFNLNGLINTRYAPEIITYKDMLRSCFIGNLTGIYHA
                     KKIGKFYQKNVGSEDYLMWLSVLKKAEKAYCIQEPLAKYRIHETSLSSNKIKSINWQW
                     NIYRKELKLNFIQSFYYLCCYIFHALKKRI"
     gene            16904..17929
                     /gene="galE"
     CDS             16904..17929
                     /gene="galE"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactose 4-epimerase"
                     /protein_id="AXL96475.1"
                     /translation="MNNPSILVTGGLGYIGSHTCVQMIQQGIQPIILDNLHNANLEVL
                     NRIETITGTKPTFYQGDVRDKAILDTIFAKHSISSVIHFAGLKAVGESVEKPIEYYDV
                     NVNGTLVLIQSMRQAGVKSLIFSSSATVYGEPEHTPLTEESSVGNTNSPYGTSKYMVE
                     RILTDLSISDNEWSISLLRYFNPVGAHNSGLMGEDPNGIPNNLTPFIAQVAVGRRKEL
                     AVFGGDYATKDGTGVRDYIHVMDLADGHIAALNYMNKDSGLYIYNLGTGTGTSVLEVI
                     AAFEKAVGKPIPYKIAERRAGDIAEYWSTPAKAERELGWKAKYTIQDMADDVWRWQSM
                     NPNGYQS"
     gene            18253..19401
                     /gene="wza"
     CDS             18253..19401
                     /gene="wza"
                     /codon_start=1
                     /transl_table=11
                     /product="putative polysaccharide export protein"
                     /protein_id="AXL96476.1"
                     /translation="MFSKFLMAITMSILISGCHLVPGTYISTSGKRTIDTGKQDINQL
                     VDIYPISPKLLSEMQIAPVIATSNPQLEEQLASYDYRVGVGDVLAITVWNHPELTIPA
                     GSYRSAADSGNWVHADGTIYYPYIGKVSVLGKTISEIRKLVSTRLAAYLEAPQIDVSI
                     AAFRSQKIYVSGEVTKPGSLPITNVPLTILEAFNTAGGLTEKADWDNVILTREGKEIK
                     ISLQSLIQYGDLTQNYLMLSGDVLYVPRNDAQKVFVMGEVGKPSTLTIDRAGMSITEA
                     LSKANGLSQTTASATGIFVIRSTHKPAPITDSEDENPFSKMAEIYQLDLSDATSLVMG
                     TEFKLQPYDLVYVTAAPVVRWNRLITQLLPTIASYNQLAEGTKRIYAW"
     gene            19490..19852
                     /gene="wzb"
     CDS             19490..19852
                     /gene="wzb"
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight
                     protein-tyrosine-phosphatase"
                     /protein_id="AXL96477.1"
                     /translation="MQGLFPQKKIHSAGLIALENQPADAQARHIAKNHHISLEENRSR
                     RLTGHLCQMADLILVMENTHTQKLYRQFPQTRGKVMLFGEWLDKTEIPDPYKHSEEMF
                     VHVYQLMEKAAESWQGKI"
     gene            19885..21972
                     /gene="wzc"
     CDS             19885..21972
                     /gene="wzc"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wzc"
                     /protein_id="AXL96478.1"
                     /translation="MNNTEKKHVPNTDEIDLLAILKTLKSNTLTIAAFTIAAILSAGV
                     YCWLASPIYQANATLQYDKVNQASLLEKMNDGMLFGGNNGQIDSEIEVIKSRMVLGKT
                     VSDLNLDIQILPSKLFSRFLSSTPVVHIAEYQLPLDLIGQPATLTFLDNCQYTLDLTD
                     QTYHGQIGIPLKQGEIHLLIDSCTAQGGEKLTLIKNDRYSAIENLRRRLSMNEASKGS
                     GIINLTIKGTNQRENIEILDNVIQNYINQNREHRKLATNNTLIFLDNYIPKIKNKLDH
                     YENQLNTFRKQNESIDLTLEAKSALESALHVEERLNELTFKEVELQQRYTRSHPAYQA
                     LLDTRQKLLLEKEKASKNIQQLPNTQQQIIRLTRDVESEQAIYNQLVTKQRELSVLNS
                     GITADVRIIDSAESYPMAIAPKKNLIMVLASLLGLVMGFAFVIGKELLNNKIKNTEEL
                     EALGLRVYATIPFSLDEKKSRYRESKKPLSIENPADMAIESIRSLRTSVYFSVMNQDN
                     NIVMVTSASPNVGKSFITANMAVVLANAGKKILLIDTDLRKGHIHKTFGLENKSGLSE
                     FLSLHGGNSISKHQQVIENLDIISRGKSTTHSSELLMSEQFKHLLDSVKHQYDMVLLD
                     TAPIFAITDPAIIGKYAGTSLLVAYYGVNTVKEIERALKHFKQNNIEITGTILNGIDE
                     KSDDYHYVYQYXP"
     gene            22141..22644
                     /gene="yibK"
     CDS             22141..22644
                     /gene="yibK"
                     /codon_start=1
                     /transl_table=11
                     /product="putative tRNA/rRNA methyltransferase"
                     /protein_id="AXL96479.1"
                     /translation="MPHIVLFEPEIPPNTGNIIRLCANTGFSLHLIHPLGFTWDDKRL
                     RRAGLDYSEFADIKHHHDYYAFLESEGLNPDNNQSPTGARVFALTTKGKPSHSNVSYR
                     EDDYLMFGPETRGLPPYVLDNMPIEQKIRIPMLAESRSMNLSNSVAVVVFETWRQLGY
                     PGALLKD"
BASE COUNT     7304 a   4265 c   4198 g   6847 t
ORIGIN
        1 atggaaagtg agcaacgcca aggggagatg cttgagcaac acatcgaagc cgaactcgcg
       61 caagctccaa tgaacgacct actttggtgg cgacggattt ccaacgccat caaaaaatgg
      121 gcgcccccag ggcaacggtt gattatcgtg accagtgaag gccgcgtgat tggtgcgatg
      181 ccgagtgaaa tgcaggtgat ccgcaacttt attggtcaat ctgataatgc cgaccatccg
      241 aagaagaaaa agtacggacg cgcagaaatt ttgggcccat tttctattcg agacggtgaa
      301 gatcattacc aactctattt agttcgccct gcaagcagcc cgcaatcaga ctttattaac
      361 ctcttgtttg acagaccatt tttactcttg attgccacaa tgttaatcag cgcaccgttg
      421 ctattatggc tatcatggag cttggctcgc cctgcccgta aattaaaaat ggcggcggac
      481 gatgtggcaa aaggtaactt gcgcccacac ccagagctag aatcgggtcc acaagaattc
      541 ttatcgacgg gtaacagttt taaccagatg atcagtgcgt tagatggcat ggtcactgcc
      601 cagcagcgat tgatttctga catatctcac gagttgcgca ccccactcac acgattacag
      661 ctagcgacgg cattattacg tcgccgccat ggtgagagta aagaactgga gcgcatcgag
      721 acagaaactc accgtttaga tagcatgatc aatgatttgc tggtgctttc tcgcagtcag
      781 cataagaatg agattcttcg cgaacacatc aaagccgatg agttatgggg agatattctg
      841 gatgatgcaa gcttcgaagc ggagcagatg aacaagacgc tggatgtcac gtcgcaccct
      901 ggctcatggc cgttatattg caatccatcc gccattggca gtgcgtttga aaacatagtg
      961 cgtaacgcgc tacgttactc aaacacccat attgcggttg atttcaaaga agaaaataac
     1021 ggtattttga ttactgtcga cgatgatggc ccgggtgtca gccctgctga ccgcgagcat
     1081 atcttccgac cgttctatcg caccgatgaa gctcgcgaca gagaaaccgg tggtacaggg
     1141 cttggcttag caattgtgga aacagcgatt tcccaacata aaggctgggt aaaagctgac
     1201 gacagcccgc taggtggatt acgcctacag atttggctgc cagaacacgg acgctaatct
     1261 tgcattatga aggtctttgg tgcttatgtg ccaaagacct ttttatatat cagccatata
     1321 ttcctatctt atttcgccga atattcccta ccaaactcaa cctgcctgat aattaacttg
     1381 ttcatattca caaacagtga tgaaattagt gtctcaaaca tttggcgata tttgcctata
     1441 cggttttact acatatactt gtaagtaaga aatagctcag acaattctta taaatattat
     1501 atttcattga ttatatcgtt attcgagtaa ttaccttttt ctacgccaca tgggcgtgat
     1561 ctatttatat attaataaca tacatcaagt tacagctgtg attatcatta ttttttatac
     1621 tatctaaccg catgcatgct ttttcttgac tattaggttg ccccctaagt atagatacca
     1681 tccaaaccaa tatactaccc aatgttaaat taacattttt tgatagagct atatactaag
     1741 aaatcactta atggtttcaa aaaggtgatc agatgattac gggtaaagta gtgattttta
     1801 ggcgtctcac accgatagtc actccgatac tttagtgcta ttattaaggg cttttgattg
     1861 attgtgctta cggcacgggt caacctatat gggaaggcta tcataagcag tgtttattaa
     1921 ttgagcagac ctgaaaaaaa tgcagcattt tcaattaata aacactaaac tctgaaattc
     1981 aatggcgctc tgggacccga taacccagtg cggtagctat gggtttatcc agcaaataaa
     2041 tctttaataa attatttacc tatcaaaaaa gtatacatat tattttgcaa aatatcttaa
     2101 gcaaattaaa gaataatccc aatatatata aaattattag taatagtagt tggttactat
     2161 ttgataaatt tactcgcatg ggattaggat tattagtcag tgtttggata gctcgctatt
     2221 taggaccatc ccaatatggt gagttggcct atgttttagc atatctagct tttttccaat
     2281 caatatcaac tttaggtatg gatagcctaa tagttcggga tattgcaaaa aataaaaata
     2341 ttgcaaatga agttttaggt acagcattca cattacgggc ttcaaccggt ttaatatgct
     2401 ggatactagc tatcattggt atgggattat taaatggctg gcatagccaa agtatctata
     2461 ttactgctct agctggggca acattagttt ttcaatcagc agatactgtt gatttatggt
     2521 ttcaaagcca aagccaaaat aaacgcaccg tcattgtaaa gctttccgct tacataatag
     2581 caaatggtat taaagttatt ttaatactta atgaagcacc attattagct tttgctgcag
     2641 tcatcacatt tgaaacaagt gctattgctt gcggtctttt ctatgcatac agaaagtttc
     2701 cttgctcaaa cttatggaat agaactaagc aaagagccat taccttatta cacgaatcgt
     2761 ggccatttat ggtcagtggc ttgtctattg ttctctacat gagagtagac cagttaatga
     2821 tcaaaaatta cttaggtgat gtagagctag gaatttatgc agcagtactt cctttggcag
     2881 cactatggca atttcttcct atgacactat ccgttagcct tgccccaatg gtagctcaaa
     2941 gtaaagccca aggagatgat cagttttaca aaacactggg ttatattttc cgtgtttttg
     3001 caatacttgg ctggctagtt tgtattccaa tatccatttt atcttacttt attgtaaata
     3061 tattatttgg tgaaacctat attgcaggtg catctgtatt atcaataatc atattcacaa
     3121 atttatttat aaacatgggt gtcgcacaaa gtttatggat agttaatgaa agaaagtcaa
     3181 agttaagcct ttataaaaca cttatgggtg cagtggtatg tgtgactgct aacataattc
     3241 ttattccata ctatggaata attggagccg ctatcagtgc agtattagca caagctgttt
     3301 cagccatgct ttctaatata atactaagta aaaaaatctt atatttacag tgtaagagtc
     3361 tacttttaat taaataatca gaaatcaatc atgaatcaac ctaacttggc tcccgttgta
     3421 ttatttgttt atggacgccc tattcataca caacgaacaa tcgatgcttt attgaaaaat
     3481 ccagaatcaa aggatactga tttaatcatt tattctgacg gaccaaagca acataacgat
     3541 acagaaaaag tagagtccgt cagagaaata attaaaaaaa catcaggatt taaaagtatt
     3601 aatttaatag aacgaactga aaatcttggt ttagctgcaa atattattga tggtgtaaca
     3661 aaagtctgtg aagaatatgg aaaagtgatt gtattagagg atgatatagt tacgtcacca
     3721 ttttttttga atttcatgaa ttcagcatta aataaatatc aaagcaatga aaaagtatgg
     3781 catataagcg gctggaatta cccacttaaa aacacggaag aacttcccga aacatttttc
     3841 tggcgtacta tgaattgctg gggttgggct acatggaaag atcgctggca atactttgaa
     3901 aaagatccat caaaactaat aactacttgg aataaagacg ccataaaaag attcaacctt
     3961 gatggcattt ataatttctg gtcccaagtt gaagtaaata tgaatggaaa actaaataca
     4021 tgggccattt tttggtatgc cacaattttc tcacataatg gcttatgcct caatccaaca
     4081 aaaagctttg ttgcgaatat tggtaatgat ggaagtggtg aaaactgcgg taattcagat
     4141 atttacaaaa gtgaattatc tcacaatccg attattgaat ggccaaatat tttcctggaa
     4201 aattcccacg ctgtaaatta cattaaattc ttctataaga agaatcaacc tagctatatg
     4261 cgtcgcattt taagtaaaat aaaacgaggt atactatgaa agttcttcat ctttctcact
     4321 ccgatattat aggaggagca gctagggcat cttatcgttt acataaagca ctactaaaat
     4381 cagatattga ttctaaaata atggtgagaa ttaaaaagtc tgacgattgg actatacagg
     4441 gcccaaaatc acacattagt nnnnnnnnnn nnnnnnnnnn nnnnnnnggc ccaaaatcac
     4501 acattagtaa actaacaaat acctttcgag ccactctggg gagagccctt acaaatctac
     4561 aacactcaga aaacatgaac ttacattcat gcaactggtt aacatcatct tgggcaaaaa
     4621 aaattaatgc tactgatgcc gacttagtcc atatacattg gattggtaat gaaacattat
     4681 ctataaaaga catcgggaaa attgaaaaac caattatatg gacaatgcat gacatgtggc
     4741 cattttgtgg taccgaacac tatgctgaag atcaaattga ctctagatgg actactggat
     4801 atacgcaaaa aaatagaata caaggtgact acagacttga tattgataag ctaatttgga
     4861 atagaaaaat aaaagcttgg aaaaatacta atatgaatat tatatctcca agcaaatggc
     4921 ttgcagattg tgcaagaaaa agtattctct ttcgtaattc aaatattaat gttataccta
     4981 accctttaga tactcaaaca tataaaccat ttgatacatc attttgtaga gaaatattaa
     5041 gattaccaca gaacaaaaat ataatattat ttggtgctat cagcggagga aatgaccccc
     5101 gtaaagggta caatttatta atagattctc tacataaact aaaatataaa gttgatagca
     5161 gctctacaat ttgtgtaata tttggacaaa gcaagcctaa gaatgtccct gaattacctt
     5221 ttccaacata ctggttagga catcttaatg atgacccaac attatcatta ctctataatt
     5281 cagctactgt aatggtagta ccatcgaccc aagaagcatt tggacaaaca gcatctgaag
     5341 ctcaagcttg tggaaaacct gtagtagctt tttccacaac tggtttgctc gatatcgttg
     5401 agcataaaaa aacagggtat ctagcgaaac catttgacac tcaagatatg gctgatgggt
     5461 tatgttggat cttaaatgat aagattgctt actctgaatt atgtattaac gctcgcaagc
     5521 gcgcgttaga actatgggct gatgatattg ttactaacag ttacctagat atatataaaa
     5581 aaataattta gtcacactaa gttttatata acactaaaat catttaatat ctaataacgt
     5641 aacacagggt tattaattga ctatactatt atcttcaatt cagttttcca tagtattatt
     5701 tttattattg tcatctaaat ttaaaactgg aaattcatta actcttattc cttgtatggc
     5761 gatgatttgg ttagttcatt ccattttagc taattcagga tacactggct tttatccgtt
     5821 atcagaaaaa gcaaacttgc ttattacctt atacttgcta ggatatgcct tctcattttg
     5881 tattttcaat cagacatcaa ataaatatgg tttattagtt tttgaattta gaaaaataat
     5941 aatagaaaag ttaataataa acttatcgct tatattaaca atattcttaa gcatagtagt
     6001 tttaatttat tccattatag catccatcga cctacaatca ttgagagata ttatttattc
     6061 ttctgacaat ccatactcgg ccattatatc tcctattata tggattgtaa cagggctatt
     6121 tttttatctt ttcctttttt cgttctatgc ttatttttca ggaaaaatac ctaaatggta
     6181 tgttattgcg tcaatattaa acattatact ttttaattta tcttcaggtg gaagaacatc
     6241 tattatttac ttattaattc tacttgcatc atcttggatt ttaattagaa aaaacattcc
     6301 ccgaccattc aatattataa aaataaatgc aacaataaaa aagggattat attccattat
     6361 tattgtaata attagtatta cagtaattag atctggtgga gatattacat ccatatacta
     6421 tacctataat aagtatttta taggctcatt cgttgctatg agtgaattca tagatgtata
     6481 taatttagaa ttacagaacg tgcggtttgg ctattcatta atgggtttag atacattcac
     6541 tgtctctggc ctttgtcgct ttatttttaa tatagatatt ccaagtattt taagccaagt
     6601 tagcggagct atgcatcatg gtgtttatat ttcaaatgat atagtaacaa atgcacatta
     6661 tactatatta acttcctttt attgggatta tggctacgct ggcgcattct tgattggatt
     6721 tttatcgtgt agtctattta ttatctttca taataaattt tacagaactc ttagctttgg
     6781 atactttact ctcactattt tcatgattct tttaattgtt tattcgataa gaacaaacat
     6841 tttattagaa cctcaatttt ttataatgtt tatctttata ttcattagaa caaagttagc
     6901 taggtaatat atgttttcaa ttgtgactat taattataac aatcatgacg ggctaaaaaa
     6961 tacttttgac tccatgaaat cgcaaactat atcaaaagag ctatatgaat ttatcgttat
     7021 cgatggaaat tcaacagata gttcaaaaaa attaatttct gataattcag aatatataga
     7081 taaagttatt attgaaaatg ataatggaat ttttgatgca atgaataaag gaatttcact
     7141 tgctgataaa aaatatattt tctttttaaa ttctggtgat caatttgaca atccaagtgt
     7201 tctaactgat atgtatgcaa tcatcaagtc aaatcctaat agaaatttat acaaaggaag
     7261 ggttaatacc tttattgatg gtactttctt aagggaggca gaattatgtc cttgggtatg
     7321 tcatcaagct gtatttttaa aaactgaact atcaaaaaaa tatttatttg atacaaatct
     7381 aaagattttt ggtgaccttg atttatggta tagacttaaa gctgatggac tttattctat
     7441 tttcgaaacc aacatattaa tttgtaatat ggaaatggat ggtgtaggaa actcacctct
     7501 ttttataaga aaacgaatac aagataaaat tattttcaac aacaaacata atttatctac
     7561 aaggttgtat attgatagaa tcatacaata tacatcttat attttcttta aattatttgg
     7621 aaaaaaagca taccataaat attatatagg ttctttaatt tatgttagaa aaaaaataca
     7681 ctcaagcatt taaaaaaata ctaactaatc ctggctttgc atatttcaaa ctaaaaaaaa
     7741 taatttcttc gataataaaa tcccctttca attttttatt ttttaaaaaa tttggtagat
     7801 tttcatatat ttcatatcat gcttcaatta taaataagcc caagataaca gttgggagct
     7861 tcgttgagat taatcgaggg tgttgtattt ggccacttag tttagatata gctaacggag
     7921 tgcaaattaa ccctaataca gtaatttatg gtgtagtttc tatcggcgag aatacaatga
     7981 ttggacctaa ttgtaatatt attggaggta atcataattt tgccaataca catgtaccta
     8041 tgaaatatca aggttcaact gagaaaggaa tcaaaattgg taatgatgta tggataggtg
     8101 ctggtgttac tattttagat ggtgtaacaa ttgggagtgg ttctatcata ggtgcaggct
     8161 caatagtgac taaagattta ccaccgtttt ccatttctgt tggcaaccct ataaggataa
     8221 taaagatcag aacatgaata ttatatttca gccatactat tactggacag gacactttaa
     8281 acaatacgct gattcattat tgggtagtga tgatatttta ataaaatcaa agaaaaataa
     8341 aaaatattct ggatttattt cttattgtta ctttagattc tattacttta cgataagttt
     8401 atttaaacta ataaaataca aaaaaaagat taataatatt tttattttgg atttcgaacc
     8461 aatatcaatc ctattattta atagattaat atttaaaaaa gaaatccaat atatcataac
     8521 aatacatgcc attgaaaaaa atgattataa gtccaccttt aaaaataaag tggcacaatt
     8581 ccaacgtttt gctcttaaat ccgcattagc tactataaat aagaaattta attgcaagtt
     8641 tgtagtccat actcatgctc atcaaactca attaattgat tttttgaaga ctgaacatct
     8701 aaatatcaat gtaattgaat atccagcacc tcagcctgct tcatcgccca attcactagt
     8761 aaaatcattc aatatatacc ctaaaagctt acttgtattt ggagcaatta gagcagataa
     8821 aggcctatat gaatttatcg agtcaatacg aaaagctaac ttagatgaat ctatagagat
     8881 tatcttcgca ggtaaggtaa tggacgatag atttgactct tacattcccc ctaagaatgt
     8941 taaaataatt aataaattct tgactgagcc tgagttacat aacctagttc aaaactgcca
     9001 cttttttctt gttccatatg cgaaaaatta tactggtggg gctggtccgg caaaagatgc
     9061 aacatcttat gggaaaccca tcataacaag taacttggca atttttaatg agttctcaaa
     9121 aaatagtttt gtttacacga taaatgatgc taatgactta aataatataa ttaataacat
     9181 tacagatact gaatatgatg catcctgtgt tgcatcctta gaatattcaa aacttaataa
     9241 ctggtcaaca ttcaggaata agtatatttc cctataattc acataatact ttacaagtac
     9301 agtaacccca tccatataaa cgattttggt ataacatatg aaaaaagcat taatcactgg
     9361 tattactggt caagatggtt cttatttagc tgaatttctt ctagagaaag gctatcaagt
     9421 tcacggtctt attcgtcgtg catcatcatt taacactgaa cgtattgact ctgttgtcaa
     9481 taatagcgac agcattaaat tgcactatgg tgatttaact gacacttcaa acttaattcg
     9541 cctagtcaaa gaaatcgaac ctgatgaaat ttataacctc ggcgctatgt cccatgtagc
     9601 agtctctttc gagtcccctg aatatactgc agatgtggat gcaattggta cattacgttt
     9661 acttgaagct atccgtataa atgggttaga gaaaaaaacc cgtttttatc aggcttcaac
     9721 ttctgagcta tacggtgaag tgcaagaaat tccacagcgt gaaacgacac cattccatcc
     9781 tcgctcccct tacgctgtag caaaaatgta cgcttactgg atcacagtga actaccgtga
     9841 atcatatggc atgtatgcat gtaatggcac actctttaac catgaatcac cacgccgcgg
     9901 tgaaaccttt gtaacacgca aaattactcg tactatcgcg aatatttctc aaggattaga
     9961 gtcatgctta tatctaggta atatggatgc acttcgtgat tggggccatg caaaagatta
    10021 cgttcgcatg caatggatga tgttgcagca agaacaagcg gatgattttg ttatcgcaac
    10081 aggtaaacaa atttctgtac gagagtttgt gagaatgtca gcaaaagaag cgggtattga
    10141 acttttattc acgggcgaag gtgttgatga aatagctact gtcactaatg ttgataagtc
    10201 aatagctcca catgttaatg tcggcgatat aattgttcgt gttagcccca aattctttag
    10261 acctgccgaa gttgaaacat tattaggcga tccatcaaaa gcgaaagaaa aactgggatg
    10321 ggtaccagag atcactgttg aagaaatgtg tgctgaaatg gttgcttcag atgtgcagaa
    10381 agcaaaacaa catgccttat tgaaggcaaa tggttttgat gtctctattt ctttagaaaa
    10441 ctaaggatta ttacgtgaaa aaaagagttt ttgttgctgg tcataatggt atggttggct
    10501 cagcaatagt tagacaactg gccaatcgta gtgatattga attaattact aaatcacgta
    10561 atgaattaga cctgacaaat caagctgatg ttgataattt ttttgctcac aatgaaattg
    10621 atgaagttta tttagctgct gcaaaagtag gcggtattca cgctaataat acttatccag
    10681 cagactttat ttatcaaaat ctcattatgg aatgcaatat cataaatgct gctcataaaa
    10741 ataatgttca gcatttacta tttttaggat cttcatgtat ttatcctaag cttgcatctc
    10801 aaccaatgtc agaacatgct cttctaactg gcgttttaga agcgactaac gagccttatg
    10861 ctattgcaaa aattgccggt ataaaactgt gtgaatccta taatcgccaa tacggtcgtg
    10921 attatcgcag tgttatgcca acaaacttat acggtgaaaa tgataatttt catccagaga
    10981 actctcacgt tattccagca ttaatgcgtc gtttccacga agcaaagctc aataatgatg
    11041 agcaagtcat tgtttgggga actggtaccc caatgcgtga attccttcac gttgatgata
    11101 tggccgcggc atctgtctat gtcatggagc ttgatatcaa gacttatcaa gacaataccc
    11161 agccaatgct ttctcatatc aacgtaggta caggcgtcga ctgcactatt cgtgaaatgg
    11221 cagaaactat agcaaaagtt gttggttttg ccggaaaagt agtctttgat agcagcaaac
    11281 cggatggaac tccacgtaaa ctcatggatg tttcacgctt gaaagatcta ggctggagct
    11341 actctattga gttagaagat ggtcttgata aaacttatca atggtttttg cagaatcaaa
    11401 ataacttccg aaaataatag gttgttaata tgacgcaacg attagaatta aatacgttta
    11461 aaacggtcgt tgcatctacg cccctcgttt ccattgactt aattgtttgc aattcaaaca
    11521 accaagcatt actaggatta cgtaataacc gcccggctca aggttattgg tttgttcctg
    11581 gaggacgtat ttgcaaagat gaaacgtttg atgatgcatt ctgtcgcctg acgcatgcag
    11641 aacttggttt ttcttacgat ataaacgaat ctatctttat tgggcattat cagcatttat
    11701 atgctgataa tttttctgaa gacaattttt caactcacta tgtcgtactg ggttatttaa
    11761 ttaaacaaga tattgacctc aatacattac cactagaaca acataataat tataagtggt
    11821 gggatatcaa tgagctactt gcttcaagtg aagttcatga taatacaaag gcttactttc
    11881 ttagtcatca cttcaattca cggtaaatta taatgttatt gcctgttatt atggccggag
    11941 gctctggtag tcgtttatgg cctctttctc gtagcttata tccaaaacaa tttattagcc
    12001 tcacgagcaa aaaaacgatg ctacaagaga ctattgctcg cctaaaaaat atagagcatc
    12061 aacctccatt actcatttgt aatgaagagc accggtttat tgttgcagaa caattgaggc
    12121 aagaaaattt taaacacagt ggtattattt tagagccagt tgggcgtaac acagggccag
    12181 caattgcatt agcggcaatt aaagccatgc aaaatggtga taacccgcta ctgcttgttt
    12241 tagctgcgga tcatgttatt caagaccatg catccttcac aaagagcatt gaaaaggcaa
    12301 tcacctccgc agaacaaggc gctttaatta cctttggtat tgttccgact gctccagaaa
    12361 caggttatgg ttatattaaa aaaggtaatt tagtcaatga atccgccttc caagttgaac
    12421 gtttcgttga aaagcctaat gtaaatactg ctgagcaata tattgctagt aatcagtatc
    12481 tttggaatag cggaatgttt ttatttaaag catcttgcta tattaacgag ttaaaaaaac
    12541 atgcccctga aatcctgtcc agctgtgagc tagcccttca aaattcgctt agtgacctag
    12601 actttacacg catcaatgcc gaaatttttg aagcctgtcc agaagactcc attgactatg
    12661 ctgttatgga aaaagcagac aatgtcttag ttgttccaat ggatgcagga tggagtgatg
    12721 tcggctcatt cagttcactt tgggaagttt cccctaaaga tcagcagtct aacgtgatca
    12781 ttggtgacgt ccttacagaa aatactaaaa atagttatgt ctactcacaa agtaaactcg
    12841 tttccactgt tggtgttgat aaccttgtta ttattgaaac taaagatgcg gttcttgttg
    12901 cgaacaaaga taatgtccaa gatgtcaaaa gtatcgttaa tcaactgaaa caagctggcc
    12961 gtagtgaatg tgagcaacac cgtgaagcat atcgcccatg gggaactcat gacgaaattg
    13021 cacaggggga acgatttcat gttaaacatt tgaaagtcaa acccggtgaa aaaaccgcac
    13081 tacaaatgca ttatcaccga gctgagcact gggtagttgt acaaggcact gcgaaggtta
    13141 ctaacggcga taaaagctat attttaagtg agaacgaatc gacctatatc cctataggtt
    13201 cacctcatcg aatagaaaat cctggaaaaa ttgaccttca tttaattgaa gttcgttctg
    13261 gaaattatct cgaagaagat gacattgttc gcattaaaga atatgggtta gatgactaac
    13321 cacctagtca ttcttnttcg cattaaagaa tatgggttag atgactaacc acctagacat
    13381 tcttaacgat gatatgatta tgaatagtta tgatgtaata aaaaaatcag gtattcagtt
    13441 tggtaccagt ggtgcccgtg gtttagtgac tcagtttact catgaagcct gtgcagcttt
    13501 cacccacgca ttcctagcaa gcatcaaaag taaatttaat tttcgtcaag tcgctatcgc
    13561 gatagataac cgcccgagta gtgaatttat tgcagcagct tgtattgacg ctatccagaa
    13621 acaaggcttt gagccgcttt tctatggcgt tatccctacc ccagcccttg cttatgctgc
    13681 aatgcaaagt aatattcctt gcattatggt aacgggtagc cacattcctt ttgatagaaa
    13741 cggtttaaag ttttatcgac ctgatggtga aataaccaag gctgatgaac ttgaaattct
    13801 gaacagtaat gtagaatttg aactctctcc tatcttagct ccgttattac ccgtaaacac
    13861 tctcgcaaca gagcaataca ttcaacgata ttgctctatc tttgatgaaa aactattaac
    13921 aggaaaacgt attggtattt atgagcactc aagtgctggt cgagatattt atccggttct
    13981 atttaagaag ctaggcgccg aagttatttc tttggaaaga agtgacgtat ttgttccgat
    14041 tgatactgaa gctgtttctg aagaagacaa aatcagggca cagaactggt ctaaattaca
    14101 cggctttgat gcaatattct caacggatgg agatggtgac cgacctctag tggctgatga
    14161 aaatggtgta tggctacgag gtgatatact aggtttacta tgttcattag aaatgggtat
    14221 tgaagcacta gcgattccgg taagttgcaa tacaattatc tcaaaagcag agcagtttaa
    14281 atgtgtaaag caaacaaaaa ttggctcacc ttatgtcatt gaagagttta ctaatttagc
    14341 tcaagaccat tccaaaattg caggctttga agccaatggt ggcttcctgc ttgggtcaga
    14401 cgttctagtt aataataaac cactcgcagc actaccaacc cgcgatgctg tcttaccatt
    14461 cctaatgtta ttatcagcag caaagaaagt aggtatcgcc tctttggtta attcattacc
    14521 acagcgcatc acttttagtg accgtataca aaactttgca acagaaaaaa gcaaaagcat
    14581 cattgaaaaa gccacaagta atcctgataa attattgagt aatttaggct ttagcgatgc
    14641 acgtatacta gaggtcaaca ctattgatgg cttaagaatg acattatcca acggtaatat
    14701 tatccatcta aggtcttctg gtaatgcacc agaattaaga tgctatgctg aagcaaatag
    14761 tgctgaaata gcgcaatcta ccgtcattca agtattacgc aaaattcaaa cattttctga
    14821 cttctaaaaa ttggttacca catgaaaata gcaatcgcag gtaccggcta cgtcggtctg
    14881 tctaacgcca tgttactgtc ccaacaccat gaagtggtgg cggtggatat cattcctgaa
    14941 aaagtggcga tgcttaacaa taagcaatcc ccaattatcg ataccgaaat cgaacagttt
    15001 ctcacggaaa aacaactcaa tttccgtgca accgaagata aagtcgaagc ctatacgggt
    15061 gcgcaatacg tgattgtggc gaccccgaca gactacgacc caaaaacgaa ctacttcaac
    15121 accaattcag tggaatccgt cattcatgat gtgaacaaac tgaacccgga agcgaccatt
    15181 atcgtcaaat ccaccattcc agtgggcttt acggagcgtc tgcgtgaaga gtttggctac
    15241 accaacgtga ttttctcccc ggaattctta cgtgaaggtc gtgcgctgtg ggataaccta
    15301 tacccatccc gtatcgtggt gggtgagcgc tcagaacgcg cacagatttt cgctgactta
    15361 ttgttagaag gcgcgattaa aaaagatgtg ccggtgctgt ttactgacgg taccgaagcc
    15421 gaagnccatc ccgtatcgtg gtgggtgagc gctcagaacg cgcacagatt ttcgctgact
    15481 tgctgttgga aggcgcgatt aaaaaagatg tgccggtgct gtttactgac gggactgaag
    15541 ccgaagcggt taaattattc gccaacacct tcttagccat gcgtgtggcg tacttcaacg
    15601 aattagacac ttacgcagaa agccgtggct taaatgcgcg tcaaatcatt gaaggcgtct
    15661 ctttagaccc acgtatcggc agccactaca acaacccatc attcggttat ggcggctact
    15721 gcttaccgaa agacaccaag cagttgctgg cgaactacga cgatgtgccg aataacctga
    15781 ttaacgcgat tgtggaatct aaccgtacgc gtaaagactt tatctcggat gcgattatcg
    15841 ctaaagcacc acgtaaagtc ggtgtgtatc gcttagtgat gaaagcgggc tccgataact
    15901 tccgtgcctc tgcggtgcag ggtgtgatga agcgtattaa agcgaaaggc attgaagtgg
    15961 tggtttacga gccagtactg aaagacgatg aattcttccg ctcgaaagtt attcgtgatt
    16021 tagacgcctt caaagcggaa agcgacatta tcctggcaaa ccgtatggta cctgaactgg
    16081 atgatgtggc ggacaaagtc tatacccgtg acctgtttgg taatgattga tatggtaact
    16141 acagaaaata acaaattggt atctattata atgccatgtt ataactctga gagattcatc
    16201 gttgagtcga ttaattctgt attagatcaa agttataaat tttttgaatt aattattgta
    16261 aatgatgcat caactgataa ctctgtaaat ttaatttctt cttataaaga ctcacggata
    16321 gtattaataa atttagaaaa aaatgaaggt gtctcctcag caagaaataa aggcttatct
    16381 attgcaaaag gtgattacat tgcttttatt gatagcgatg atatatggat atcaaataaa
    16441 ctagaaaagc aaattgaatt attaaataaa gactgggatg tgatatgttc aaattattct
    16501 acatttaact taaatggatt aattaacact cgatatgccc cagaaataat aacatataag
    16561 gacatgctac ggtcttgttt tattggtaac ttaactggaa tatatcatgc aaaaaaaata
    16621 gggaaatttt accaaaaaaa tgtagggtca gaagattatt taatgtggtt atctgtacta
    16681 aaaaaagccg aaaaagcata ctgtatacaa gaacctttag ctaaatatcg cattcacgaa
    16741 acatccttgt ctagtaataa gataaaatca attaattggc aatggaatat atacagaaaa
    16801 gagctcaagc taaactttat acaaagtttc tattatcttt gttgttatat ttttcacgca
    16861 ttaaaaaaaa gaatttaata ttaagaaaaa ataaggtgaa ataatgaaca accctagcat
    16921 tttagtcacc ggcggtcttg gctatatcgg cagccatacc tgcgtacaaa tgatccaaca
    16981 aggtattcag ccgattattt tagataatct tcataatgcc aaccttgaag tgcttaatcg
    17041 cattgaaacc atcacgggaa ctaaaccgac gttttatcaa ggtgatgttc gtgataaagc
    17101 cattttggat accatttttg ctaaacattc cattagctca gtcatccact ttgcggggtt
    17161 aaaagcagtc ggtgaatctg tcgaaaaacc tattgaatac tatgatgtaa atgtgaatgg
    17221 caccttagtt ttaatacaaa gtatgcgtca ggcgggtgtt aaaagcttaa tttttagctc
    17281 ctctgcgaca gtgtatggtg agcctgaaca taccccgtta actgaagaat cctctgtcgg
    17341 aaataccaat agcccatatg gtacgagtaa atatatggtt gagcgtattt taactgacct
    17401 cagtatctca gataacgaat ggtcaatttc cttactgcgc tacttcaacc cagttggtgc
    17461 acataattct ggcttgatgg gtgaagaccc taatgggatc ccaaataacc tgaccccatt
    17521 tattgcgcaa gtagctgtcg gtcgccgtaa agaacttgct gtattcggcg gggattatgc
    17581 caccaaagac ggcactggcg tccgcgatta tatccatgtg atggatttag ctgatggaca
    17641 tattgctgcg ttaaactata tgaataaaga ttcagggctt tatatctata atctgggtac
    17701 cggtacagga accagcgtgc tggaagtgat cgctgctttt gaaaaagctg tcggtaaacc
    17761 aatcccttat aaaattgccg aacgtcgtgc aggagatatt gctgaatatt ggtcaactcc
    17821 agcaaaagca gagcgcgagc ttggttggaa agccaaatat accattcagg atatggctga
    17881 tgatgtatgg cgctggcaat ctatgaatcc taacggttat caaagctaaa tcattcttta
    17941 tatagcatca attaggcgag ccaccggctc gcttttttat tttttacatt ctcaaacttt
    18001 attctcacca cacagttaac ctactcactc cctagttcgc ttctagtcta ttcctccaac
    18061 cacctttcac tcacaaaaca ttttctgcat caatatcatt ttttgtttta ttatattttt
    18121 atataacatc gatttttgga tgaattattt ggttttttgt ttaaaactga actattatcc
    18181 cgagctgact ttgtgtcgtg taacttcgat tgctaaaaat taccattatc catcctgatt
    18241 agggctatta tcatgttcag taaatttctc atggctatca caatgagcat cctaatttct
    18301 gggtgtcatc tcgtcccggg aacctatatt tccacatcag gaaaaaggac tattgatact
    18361 ggtaagcaag atatcaacca acttgtggat atttacccta tctcccctaa gctgctaagc
    18421 gaaatgcaaa ttgcccctgt gattgccaca tctaatcctc agcttgaaga gcagctagca
    18481 agttatgact atcgtgttgg cgtgggggat gtgctggcaa ttaccgtatg gaatcaccct
    18541 gagctcacta tccccgctgg ctcctatcgc agcgctgcgg attcagggaa ttgggttcac
    18601 gcagatggca ccatttatta tccctatatt ggaaaagtct ccgttcttgg taaaacaatc
    18661 agtgaaatca ggaaattagt cagcacccga cttgctgctt accttgaagc gccacaaatc
    18721 gatgtcagca ttgccgcctt tcgttcgcaa aaaatttatg tgtctggcga agtgactaag
    18781 ccgggttcct tgcccatcac taatgtccct ctcactattt tggaagcctt taataccgca
    18841 ggcgggttaa ccgaaaaagc ggactgggac aatgtgatcc tcacccgtga aggcaaagag
    18901 ataaaaatct cgctgcaatc gttaattcaa tacggcgatt taacccaaaa ctacttaatg
    18961 ctatctggcg atgttctcta tgttccccgt aatgatgcgc aaaaggtctt tgtgatggga
    19021 gaagtgggga aaccatcaac attgactatc gaccgggcag gaatgagcat cactgaagcg
    19081 ctaagtaaag ccaatggact cagccaaact accgcaagtg caacagggat ttttgtcatt
    19141 cggtcaacgc ataaacccgc accaataaca gattctgaag acgagaaccc cttttctaaa
    19201 atggcagaaa tttatcaact cgacctctcc gatgcgacat cactcgtgat gggaactgaa
    19261 tttaaattac aaccttatga ccttgtttat gtgacagcgg caccagttgt tcggtggaac
    19321 cgtttaatca cccaattact gccaaccatc gcctcataca accagcttgc cgaaggaact
    19381 aagcgtattt atgcatggta atcttatttt taatcaaata cttatgttta ataacattct
    19441 tatcgtatgc atggggaaca tctgccggtc acccactgcg gagcgtttaa tgcaggggct
    19501 tttcccccaa aaaaagatcc actccgcagg gctgattgca ctggaaaatc aacctgctga
    19561 tgctcaagct cgccatatag caaaaaacca tcacatttct ttggaggaga atcgttcacg
    19621 tcgtttaacc gggcatttat gccagatggc ggatttgatc ctcgtaatgg aaaacactca
    19681 tacccaaaaa ctttatcggc aatttccgca aacccgaggc aaagtcatgt tattcggtga
    19741 atggctggat aaaaccgaaa tcccagatcc ttataaacat agcgaggaga tgtttgtgca
    19801 tgtttatcag cttatggaaa aagcagccga gtcgtggcaa ggaaagattt agactctatt
    19861 taaacttatt taaaaactaa ctctatgaac aatacagaaa aaaagcatgt gccgaacacc
    19921 gatgaaatcg acttactcgc catactaaaa acactgaaat ctaacacgct aacgatagcg
    19981 gcgtttacta ttgccgccat tttaagtgcc ggagtgtatt gctggctcgc ttctcctatt
    20041 taccaagcga atgctacatt acagtacgat aaagtaaacc aagcctcact attagaaaaa
    20101 atgaacgatg gaatgctttt tggcggcaat aacgggcaaa tcgattcaga aattgaagtc
    20161 attaaatcca gaatggtgtt aggcaaaacg gtgtcagatt tgaatctaga tattcagatt
    20221 ttgccttcaa agttattctc cagatttcta agtagtactc ccgttgttca tattgcagag
    20281 tatcaactac ccctagattt aatcggtcaa ccagctactt taaccttttt agataattgc
    20341 caatatacgt tggaccttac ggaccaaact tatcatgggc aaattggcat ccctttaaag
    20401 caaggtgaaa ttcacttatt gattgattca tgtaccgctc aaggtgggga aaaactgacc
    20461 ttaataaaaa atgatcgtta ttctgctatc gaaaatttac gacgccgtct cagtatgaat
    20521 gaagccagta aaggctctgg tatcattaac ttaacaatta aagggacaaa tcagcgagaa
    20581 aatatcgaga ttttagataa tgtgattcaa aattatatta atcaaaatag agaacatagg
    20641 aagctagcta caaacaacac gttgattttt ctagataact acataccaaa aataaaaaat
    20701 aagctcgacc attatgagaa tcagttaaat acgtttcgta aacaaaatga gtccattgac
    20761 ctaacgctag aggccaaatc cgcgcttgag agtgcattgc atgtagaaga aaggctaaat
    20821 gagcttactt ttaaagaagt ggagcttcaa caacgatata cccgcagcca cccggcttat
    20881 caagccttac ttgatacacg ccaaaagttg ctactcgaga aagaaaaagc cagcaaaaat
    20941 attcaacagc tgccaaacac ccagcagcaa attattcgtt taactcgtga tgttgaatcc
    21001 gagcaagcta tttataatca gttggtgacc aagcaacgcg aactcagtgt gctgaattca
    21061 gggatcactg ccgatgtgcg aattattgac tctgcggagt cttaccccat ggccatcgct
    21121 cccaagaaaa acttaatcat ggttttggcc tctttattgg gtctcgtgat gggcttcgcc
    21181 tttgtgatcg gaaaagagct tctcaataat aaaattaaga acacggaaga actcgaggcg
    21241 ctaggccttc gtgtttatgc cactattcca ttctcgttgg atgaaaaaaa atcacggtat
    21301 cgcgaaagta aaaagcccct atccattgaa aatccagcag atatggcaat agaatccatt
    21361 cgttcattaa gaaccagtgt ctatttctct gttatgaatc aagacaataa tattgtgatg
    21421 gtgacaagtg catccccaaa tgtcggaaaa agttttatta ctgcaaatat ggctgtcgtc
    21481 ctcgccaatg caggtaaaaa aattctgctt attgataccg atttacgcaa aggacatatt
    21541 cataaaacat ttgggttaga aaataaatct gggctttcag aattcttatc tctacacggc
    21601 gggaattcca tctcaaaaca tcaacaagtt attgagaatt tggatattat cagtcgagga
    21661 aaaagtacca cgcactcttc agaactgctt atgagcgagc aatttaagca tttattggac
    21721 tcagttaagc atcaatatga catggttttg ttggacactg cgcccatttt tgcgattaca
    21781 gatcccgcta ttatcggaaa atatgccggc acatcactct tagtggccta ttatggcgtg
    21841 aataccgtta aagaaattga acgcgcactt aaacatttca aacaaaataa tatcgaaatt
    21901 actggcacca tccttaatgg cattgatgaa aaatctgacg attatcatta tgtctaccag
    21961 tattancctt aatggcattg atgaaaaatc tgacgattat cattatgtct accagtatta
    22021 atagaatggc gagccacccc tcgcctttcg ctctcatacc gacacaacta atgcatcttt
    22081 ccaaatttgc gcgtaaactc tgcatcatct ttttcatccc gaccaatagc cgttaacgtt
    22141 atgccacata ttgttttatt cgaacctgaa atcccaccaa atactgggaa tatcatccgc
    22201 ttatgcgcca atacaggctt tagtctgcac ctgatccatc ccctcggttt tacttgggat
    22261 gacaaacgct tacgccgtgc agggctagat tacagcgaat ttgcggatat caaacatcat
    22321 catgactatt acgcattctt agaaagtgaa gggttaaatc ctgataataa tcagtcgcca
    22381 acaggtgctc gtgtgtttgc gttgaccacc aaaggcaagc cgagccacag caatgtgagc
    22441 tatcgggaag atgattattt gatgtttgga ccagaaaccc gcggtttacc tccttatgtt
    22501 cttgacaata tgccaatcga gcagaaaatt cgtatcccga tgctggctga aagccgcagt
    22561 atgaatcttt ctaactcggt cgccgttgtg gttttcgaaa cttggcgcca gcttggatat
    22621 ccgggtgcgc tgctgaaaga ctaa
//
