LOCUS       JX975330               15293 bp    DNA     linear   BCT 27-AUG-2013
DEFINITION  Salmonella enterica strain G2463 O antigen gene cluster, complete
            sequence.
ACCESSION   JX975330
VERSION     JX975330.1
KEYWORDS    .
SOURCE      Salmonella enterica
  ORGANISM  Salmonella enterica
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Salmonella.
REFERENCE   1  (bases 1 to 15293)
  AUTHORS   Liu,B., Knirel,Y.A., Feng,L., Perepelov,A.V., Senchenkova,S.N.,
            Reeves,P.R. and Wang,L.
  TITLE     Structural diversity in Salmonella O antigens and its genetic basis
  JOURNAL   FEMS Microbiol. Rev. (2013) In press
   PUBMED   23848592
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 15293)
  AUTHORS   Liu,B., Knirel,Y.A., Feng,L., Perepelov,A.V., Reeves,P.R. and
            Wang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-OCT-2012) TEDA School of Biological Sciences and
            Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin
            300457, P.R. China
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..15293
                     /organism="Salmonella enterica"
                     /mol_type="genomic DNA"
                     /strain="G2463"
                     /db_xref="taxon:28901"
                     /note="serogroup: O39"
     misc_feature    1..15293
                     /note="O antigen gene cluster"
     gene            106..1179
                     /gene="rmlB"
     CDS             106..1179
                     /gene="rmlB"
                     /note="RmlB"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase"
                     /protein_id="AFW04689.1"
                     /translation="MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLS
                     EISESNRYIFEHADICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIV
                     GTYVLLEAARKYWSALGEDKKNSFRFHHISTDEVYGDLPHPDEVDNIVTLPLFTETTA
                     YAPSSPYSASKASSDHLVRAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KPLPIYGKGDQIRDWLYVEDHARALYMVVTEGKAGETYNIGGHNEKKNLDVVFTICDL
                     LDEIVPKATSYREQITYVADRPGHDRRYAINADKISRELDWKPQETFESGIRKTIEWY
                     LNNTEWCRRVQDGSYQRERLGLE"
     gene            1181..2050
                     /gene="rmlA"
     CDS             1181..2050
                     /gene="rmlA"
                     /note="RmlA"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="AFW04690.1"
                     /translation="MKGIILAGGSGTRLYPITMGISKQLLPIYDKPMIYYPLSVLMLA
                     GLRDILIITTPEEQDIFIRLLGDGSQFGINLSYAIQPSPDGLAQAFIIGEDFIGQDSV
                     CLVLGDNIFFGQGFTPKLRTAVERKSGATVFGYQVMDPERFGVVEFDNNFKALSIEEK
                     PINPKSNWAVTGLYFYDNNVIDIAKSIKPSTRGELEITAVNEIYLKSNELTVEVLGRG
                     FAWLDTGTHDSLIEAGSFVETVQKRQGMMVACPEEIAWRNGWLSNSELLELGNKLKKN
                     RYGQYLIKVASQI"
     gene            2047..2442
                     /gene="qdtA"
     CDS             2047..2442
                     /gene="qdtA"
                     /note="QdtA"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-6-deoxy-3,4-keto-hexulose isomerase"
                     /protein_id="AFW04691.1"
                     /translation="MNVELIPLQIHGDKRGSLISLERGINVPFDIRRIYYIFDTKKDV
                     VRGFHAHKKLKQIAIVIKGSCDFTLDNGRERISLTLNNPAQGLLIDSFIWREMSNFTS
                     DCVLMVLADQEYNESDYIRDYEQFKQMVK"
     gene            2443..2898
                     /gene="qdtC"
     CDS             2443..2898
                     /gene="qdtC"
                     /note="QdtC"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-Quip3N acetylase"
                     /protein_id="AFW04692.1"
                     /translation="MFIHKLSDVHSSKIGKNTRIWQYTVIMQGAVIGEDCNICAHTLI
                     ENDVLIGNRVTIKSGVYIWDGITIEDDVFIGPCVTFTNDKLPRSKKYPEKFSLTVIKK
                     GASIGANATILPGIIIGEGAMVGAGSVVTKNVPAHATVIGNPARNIKVK"
     gene            2900..4003
                     /gene="qdtB"
     CDS             2900..4003
                     /gene="qdtB"
                     /note="QdtB"
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase"
                     /protein_id="AFW04693.1"
                     /translation="MVDFLNLQKINNRYEHELKEACARVIDSGWYILGTELTNFEQEY
                     ASWCGVKHAIGVANGLDALTLVFRAWKEMGKLHSGDEVIVPANTYIASVLAITQNDLV
                     PVLVEPDALTFNLEENGIRNAITNKTKAILPVHLYGQISPMEEIMEIALAHNLLVLED
                     CAQAHGAAINKRQAGAWGHAAGFSFYPGKNLGALGDAGAVVTNDTQLAEMLMALRNYG
                     SHEKYKNKYQGVNSRLDEIQAAMLRVKLRYLDNDNILRKHIAQRYLNEINNINISLPT
                     VTHTEGHVWHLFVIQTTYREELQRYLSSYGIQTLIHYPLPPHKQQAYNHLNNLVLPIT
                     ENMHERVLSLPMDPNMSKNDIDKVIKVVNSFRV"
     gene            4000..5253
                     /gene="wzx"
     CDS             4000..5253
                     /gene="wzx"
                     /note="Wzx"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="AFW04694.1"
                     /translation="MKKIFKVTALSGLLTLLKMIMGFIIAKIIAIYTGPAGMAMLGQI
                     QSIINSFNGIINSPVGSGIVRFTAENHSRGYDKCSPWWRASLEWMIVLCAVLIPLGIL
                     SSDLLSTWLLQTPDYSWTICLIVIFLPLSALGTFIISIINGLESYRRYITLIMISVII
                     SSAIMVLMIIYAGIRGALIAAIIQSSLIGLIMLIGNIKQPWFMLHYLWGETHSKARKD
                     IAGYIIMAITTAITAPLSLILVRNVIITQVGWEQAGQWQAVWKISEVYLSVITIALGT
                     YYLPKLSALIGSEIIIKEINRTAIYVIPFAIILASIVYIFRDFIIHILFTPDFKPARD
                     LFMIQLCGDVIKIASWLYAYPMLSRGATKWYVLTEIVFAITFVAFAWLFINIVNNAHG
                     ANYAYLLNYVIYLLFILLNFKRIVR"
     gene            5273..6526
                     /gene="wdaO"
     CDS             5273..6526
                     /gene="wdaO"
                     /note="WdaO"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AFW04695.1"
                     /translation="MQKLVVYHPSKYLGGTEVLFSRILDLLISRKYENIHIIDYSDGV
                     LSSRFYKTSITYHNVISYDVKEVLDGAVVIASARNISRVIYESKQNNVKYIKPLFWLL
                     HPSELYAGYCLGSTFLKRLSYKLLYRYIKLLPAIKVYMSIINKLDLNNNIWIMDRSCQ
                     LESEWALNYKFREKVILPLITNLDYQPVKNIEQERYTILIISRLDDFKIHGIVKLLDD
                     IIQYTKKNKSCKISVHIVGDGIAGKFLKENYVNSINMDVFFHGYVSGKKLTELFHNGN
                     YSLLFAMGTSALEGASRGLPTVLLPCTDKSIRNRDNVYRYLHIDNDQGLGEYIDTPFE
                     GTEYLTFNEIVEIFNRDKENLVCNTRKYFLNNYGKEITQKKFLLSLEKVKILSINEVK
                     ISLTFRIYTKFILKKRLSTGGLILE"
     gene            6532..7872
                     /gene="wzy"
     CDS             6532..7872
                     /gene="wzy"
                     /note="Wzy"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="AFW04696.1"
                     /translation="MPIAVHLIELAYVLIIISFIILFYMKNVPLLEGGFLLLIICSPY
                     SISIIPFRQDTIELYGLYSNSGLLNLFNFYKVAGLSILDLIALLVIVKNFKLALKMPI
                     FFKFFYILISFFSIIAYAISAYLIWSPELDNVIRALSVFKSIIYIISIYCVIEKICSR
                     IGFKLFLKILMNIILTYCIINCVLLSFLPSWYTWVKYSFNYLFLDQTDQFLVFLFCLL
                     TFWGPLSKLYRYKLYAFLLCIMLFLSGGKAGVYSIMILAMGWLYQKSNIKGSNLGVIF
                     LCAMIFSWLLSYFIGVYELDISIYSRYFQVQQLFLNYSNNILLVFFGIGPSKAYIFYD
                     FPTIFDPGAYTSEELSSSFRLGFQMPYLSWIKNFGLSGVILLLLALNYIIKVAWSFKK
                     DDIFFSGAVYSLGLYFILIGFMDFPAFGLKTIIPISLYIYIINNKLTYKKQEII"
     gene            7869..8909
                     /gene="wdaP"
     CDS             7869..8909
                     /gene="wdaP"
                     /note="WdaP"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AFW04697.1"
                     /translation="MIVIDGVIFSLQKSGGISVYFSELLRRIRTDKEDVLHLLYNNQN
                     IYTKGSDYVVNRIARLHISVERFIKVNISGTKNDIFHSSYYRLPNAKFNGKIITTVHD
                     FTEEIYPRGLISKVHHKQKRQAILGSDGIICISNNTMKDMHKFIPESVNIPTRVIYNG
                     VGDFSVRNIDAKFESYVIFVGARSGYKNFKMCVSALRYFDDIELIVVGGGEFSKEEIK
                     FLDSEIPGRYVHAGFLSEKELNRLYQNALALIYPSLYEGFGIPVIEAMKSGCPVIASK
                     TSSVEEISNEAAILIDNISAHQIRDCIHNLKNPSFRMEKIALGIENANGYSWDKMALE
                     TVDFYNYIRGLK"
     gene            8906..10024
                     /gene="gmd"
     CDS             8906..10024
                     /gene="gmd"
                     /note="Gmd"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="AFW04698.1"
                     /translation="MKVALITGITGQDGSYLAEFLLEKGYTVHGIKRRSSSFNTERVD
                     HIYQDPHVNNPKFHLHYGDLTDTSNLTRILSEVKPDEVYNLGAMSHVAVSFESPEYTA
                     DVDAIGTLRLLEAIRFLGLEKKTKFYQASTSELYGLVQEIPQKESTPFYPRSPYAVAK
                     LYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGLESCLYLG
                     NMDSLRDWGHAKDYVRMQWMMLQQEYPEDFVIATGKQISVREFVRMAALEAGIELEFS
                     GVGVDEVGTVVKVTGDSEKYVRVGDEIVRVDSRYFRPAEVETLLGDPSKAKDKLGWVP
                     EISVEEMCREMVNSDLQKAKQYALLRENGFDVSISLEN"
     gene            10028..10990
                     /gene="fcl"
     CDS             10028..10990
                     /gene="fcl"
                     /note="Fcl"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-fucose synthetase"
                     /protein_id="AFW04699.1"
                     /translation="MTKRVFVAGHNGMVGSALVRMLQQEQDIEIITRKRNELDLLSQQ
                     AVSSFFKSERIDQVYLAAAKVGGIYANNTYPADFIYQNLMIECNIINAAFHNGVQKLL
                     FLGSSCIYPRDTIQPIREDALLTGILESTNEPYAVAKIAGIKLCESYNRQYGCDYRSV
                     MPTNLYGPNDNFHAENAHVIPALLRRFHEASLDESESVIVWGSGNPMREFLYVDDMAA
                     ASVHVMNLPKEIYDKNTAPMLSHINVGTGVDCTIRELAETIASVVKFRGDIIFDESKP
                     DGTPRKLLDVSRLANMGWRWSTSLEEGLQLTYAWFLKNQEKFRK"
     gene            11000..11446
                     /gene="gmm"
     CDS             11000..11446
                     /gene="gmm"
                     /note="Gmm"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose mannosylhydrolase"
                     /protein_id="AFW04700.1"
                     /translation="MLDYALFKTIVDNTPLISIDLIIYNAKSEVLLGKRNNPPAKAHY
                     FVPGGRIYKNEKITEAFQRICKAEIGVDIYLQSARFLGVFEHFYEDAYVGEDISTHYV
                     VLAYEIHMDLELNMLPLAQHNQYVFMPSELIASTSEVHFYTQRYFC"
     gene            11456..12850
                     /gene="manC"
     CDS             11456..12850
                     /gene="manC"
                     /note="ManC"
                     /codon_start=1
                     /transl_table=11
                     /product="GDP-mannose pyrophosphorylase"
                     /protein_id="AFW04701.1"
                     /translation="MSNIILPVVMAGGAGSRLWPLSRALYPKQFLSLTSTNSMLQETI
                     IRLEGIEHEYPLFICNEEHRFIVAEQLRQLSIDHSGIILEPDGRNTGPAIALAAFHAL
                     NNGYDPVMLVLAADHEIQERKNFIDSIEIAKQFAENDKLVTFGIVPASPETGYGYIKV
                     GEKIGPDGYKVAAFVEKPHRLLAEEYINSGKYLWNSGMFMFKASVFLNELKKFRPDIY
                     SICETSLLKSESDLDFIRVNGKVFNCCPSESIDYAVMENTMQAVVVPLDAKWSDVGSW
                     TALWDISKKNENGNIIRGDVIAKDTDNCYLHSESRLIGTVGVKDLVIVETKDAVLVAH
                     KNNVQDVKNIVEQLKIQNRQEYLHHREVYRPWGSHDAVADGERFRVKHVTVLPGHAIS
                     KQVHYHRAEHWVIVSGTARVYIGDENFLLGENESTFIPVGTVHSIENPGKIPLEIIEV
                     QSGTYLHEDDVERS"
     gene            12953..13717
                     /gene="wdaG"
     CDS             12953..13717
                     /gene="wdaG"
                     /note="WdaG"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="AFW04702.1"
                     /translation="MKVSIITATYNSQDTLKDTLLSVEQQDYPDIEYIIIDGGSSDQT
                     LQLIKKYSTRVKCLISEKDNGIYDALNKGVKLATGDIVGFIHSDDILASPQVISNIVN
                     KFKGNTADIVYGDLLFVDREKPDIIHRFWHSGEFKKSKLRYGWAPPHPAFYIRRALYK
                     KYGCFDLNFKIAADYDQMLRLLLVPYLQIIYVPEVFVKMRLGGESTKLNNALLSTKEI
                     IAIMRKHNINWQVAILTRKLSKLWQIFSKFKRSNIS"
     gene            13714..15084
                     /gene="manB"
     CDS             13714..15084
                     /gene="manB"
                     /note="ManB"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase"
                     /protein_id="AFW04703.1"
                     /translation="MKKLPCFKAYDIRGRLGEELNEDIAWRIGRAYGEYLKPKTIVLG
                     GDVRLTSEALKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPM
                     DYNGMKLVREGARPISGDTGLRDVQRLAEAGDFPPVNEAARGSYRQISLRDAYIDHLL
                     GYISVSNLTPLKLVVNSGNGAAGPVIDAIEARLKALGASVEFIKIHNTPDGTFPNGIP
                     NPLLPECRDDTRKAVIEHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLE
                     KHPGAKIIHDPRLTWNTEAVVTAAGGTPVMSKTGHAFIKERMRTEDAIYGGEMSAHHY
                     FRDFAYCDSGMIPWLLVAELVCLKGQSLGELVRDRMAAFPASGEINSRLAEPAAAIAR
                     VESHFAEEAQAVDRTDGLSMSFPDWRFNLRSSNTEPVVRLNVESKANTELMEEKTQAI
                     LTLLRK"
BASE COUNT     4782 a   2400 c   3226 g   4885 t
ORIGIN
        1 attggtagct gtaagccaag ggcggtagcg tgtgtaacga cttgagcaat taatttttat
       61 tggcaaatta aataccacat taaatacgcc ttatggaata gaaaagtgaa gatacttatt
      121 actggcgggg caggttttat tggatcagct gttgtccgcc atattattaa gaatacacag
      181 gacactgtag ttaatattga taaattaacc tacgccggta atcttgaatc cctttctgaa
      241 atttctgaaa gtaatcgcta tatttttgaa cacgcggata tttgtgattc tgctgagata
      301 acgcgtattt ttgagcagta tcagcctgac gcagtgatgc atttggctgc agaaagccat
      361 gtggaccgtt cgattaccgg gccggcagca tttattgaaa ccaatattgt cggaacctat
      421 gtgctgcttg aagctgcgcg taaatattgg tctgcgcttg gcgaagataa aaagaatagt
      481 ttccgctttc atcatatttc aactgacgaa gtttatggcg atctaccaca tcctgatgaa
      541 gttgataata tcgttacatt gccgttattt actgaaacga cggcatatgc gccaagtagt
      601 ccgtactccg cttcaaaagc atccagcgat catttagtcc gtgcctggaa gcgtacttat
      661 ggtctaccaa cgatcgttac taattgttct aataattatg gaccttatca ctttcctgaa
      721 aaacttattc cgttggtcat tttgaatgcg ctggaaggaa agcctttgcc aatttatggc
      781 aaaggggatc agattcgcga ctggttatat gtagaagatc acgctcgcgc gctttatatg
      841 gtagtgactg aaggtaaggc aggggagact tataacattg gtggccacaa tgagaagaaa
      901 aatctcgatg tggtatttac catctgtgat ctgctggatg agattgtacc caaagcgact
      961 tcttatcgtg aacaaatcac ttatgttgcg gatcgtccag gccatgatcg tcgttatgcc
     1021 attaatgctg ataaaattag ccgtgagtta gattggaaac ctcaggaaac ttttgaaagt
     1081 ggtattcgta aaactattga gtggtattta aataatactg aatggtgtcg tcgagttcag
     1141 gatggtagct atcaacgtga gcgtttagga ttagaataaa atgaaaggta ttattttagc
     1201 aggtggatca ggaacaagac tttatcctat tacaatgggg atatctaaac agttactccc
     1261 catttacgat aagccgatga tttattaccc tctctctgta ttgatgctag ccggtttaag
     1321 agatatttta ataattacca ctccagaaga acaggatatt tttatccgac ttctaggtga
     1381 tggtagtcaa tttggtatta atttatccta tgctattcaa ccgtcacctg atggacttgc
     1441 tcaagcgttt attattggcg aagatttcat tggacaggac tctgtttgcc tagtattagg
     1501 tgataatatt ttttttggac aagggtttac accaaaattg agaacggctg ttgaaagaaa
     1561 gtcgggagct acagtttttg gctatcaagt catggaccca gagcgttttg gtgtagtcga
     1621 atttgataat aattttaagg cattaagcat tgaggagaaa ccaattaatc ctaaatcaaa
     1681 ttgggcagta acaggactct atttttatga taataatgtt atagatattg caaaatcaat
     1741 taagccatca actcgtggtg agctggaaat tacagcggtt aatgaaattt accttaaaag
     1801 taatgaactt actgttgagg tgttaggtcg tggtttcgca tggcttgata ctggtacaca
     1861 tgatagccta atagaagcgg gtagtttcgt agaaacagtt cagaaacgac aggggatgat
     1921 ggttgcatgc ccggaagaga ttgcatggcg taatggttgg ttgagtaaca gcgagttatt
     1981 agaactgggc aataaattga aaaagaaccg ctatgggcaa tacctaatta aagttgcgag
     2041 tcaaatatga atgttgagct aataccatta caaatacatg gcgataaaag aggatcttta
     2101 atatctttgg agagaggtat taacgtccct tttgatattc gtagaatata ttacatattt
     2161 gataccaaaa aagatgtcgt aagaggtttt catgcacata agaaattaaa gcaaatagct
     2221 attgtgatta aaggatcctg cgattttacg ttagacaatg gacgagagag gatttcactt
     2281 actttgaata atcctgctca agggttacta attgattcgt tcatatggcg tgaaatgagt
     2341 aattttactt ctgattgtgt gcttatggtt ttagcagatc aagagtataa tgaatccgat
     2401 tatattcgtg attatgaaca atttaaacaa atggtaaagt aaatgtttat acataagctt
     2461 agcgatgtac attcatctaa gataggaaaa aatactcgaa tatggcaata cactgtaata
     2521 atgcaagggg ctgttatagg ggaagattgt aatatttgtg ctcacacact aattgaaaat
     2581 gatgttttaa ttggcaatag agttacaata aaatccggtg tttatatctg ggatggtata
     2641 actattgaag atgatgtatt tattgggcca tgtgtcactt tcactaatga taaattacca
     2701 agatctaaaa aatatccaga aaaattttct cttactgtga taaaaaaagg agcatcaata
     2761 ggcgcaaatg caacaatcct tccgggtatt ataatcggag aaggcgctat ggttggtgcg
     2821 ggatctgttg ttacaaaaaa tgtacctgca catgcaacag ttatagggaa tccggcaaga
     2881 aacattaagg tgaaataata tggtagattt tctgaactta caaaaaatta ataaccgtta
     2941 tgaacatgaa ttaaaagaag cttgtgcaag agttatcgat tctggttggt atattttggg
     3001 tacagagtta actaattttg aacaagaata tgccagctgg tgtggtgtaa agcatgccat
     3061 tggggtagct aatggtctgg atgcgttaac actagtattt agagcatgga aagaaatggg
     3121 gaaattgcat agtggtgatg aagttattgt ccctgcaaat acctatattg cttcagtatt
     3181 agctataact caaaacgatc ttgtacctgt attagtggaa cccgatgcgt taacttttaa
     3241 tttagaggaa aatggtatac gaaatgctat aactaataaa acaaaagcaa ttttacctgt
     3301 acatttatac gggcaaatat ctccgatgga ggagataatg gagatagctt tggcacataa
     3361 tttattggta cttgaggatt gtgctcaagc acatggtgcc gcaatcaata aacgtcaggc
     3421 tggagcgtgg gggcatgcgg cgggttttag tttttatcca ggtaagaatc ttggagcttt
     3481 aggcgatgcg ggggctgttg ttacaaatga tactcaatta gctgaaatgt tgatggcgct
     3541 gagaaattat ggctcgcatg aaaaatataa aaataaatat caaggcgtga atagtcgttt
     3601 agatgaaatt caggcggcta tgctgcgggt aaaattacgt tatttggata acgataatat
     3661 tttaaggaaa catatagctc aacgatatct aaatgaaatt aataatatta atatttcatt
     3721 gccaactgtc acacatactg aaggccacgt ttggcatttg tttgttatac aaactaccta
     3781 cagagaagaa ttacagcgat acttatcttc ttatggaata caaacattga tccattatcc
     3841 attacctcct cataaacaac aggcttataa tcaccttaat aatttagtgc tccccataac
     3901 tgaaaatatg catgagagag tcttatcgtt gcctatggat ccaaatatgt caaaaaatga
     3961 tattgataag gtaattaaag tagttaatag cttccgagta tgaaaaaaat atttaaagta
     4021 acagcattga gtggactatt aacattgctt aaaatgataa tgggcttcat tattgctaaa
     4081 ataattgcta tatataccgg gccagccggt atggctatgc ttggccaaat tcaaagtatt
     4141 ataaatagtt tcaatggtat tataaattcc cctgtaggta gtgggatagt tagatttacg
     4201 gccgaaaatc attcacgtgg ctatgataaa tgctctccgt ggtggagagc atcattagaa
     4261 tggatgattg tcctttgcgc tgtattgatt ccgctgggga ttctatcatc tgatttatta
     4321 tcaacttggc ttttgcaaac tccagattat agttggacta tatgtcttat agtcatattt
     4381 ttacctttaa gtgcactggg tacctttatt atctctatta taaatggatt agagagttat
     4441 cggagatata ttacgttgat aatgatatcg gtaattatat ccagtgcgat aatggtttta
     4501 atgattatat atgcaggaat taggggggct ttaatagcag caataattca atcatctttg
     4561 attggactaa ttatgctaat agggaatatt aaacaaccat ggtttatgtt acattattta
     4621 tggggggaga ctcacagtaa agctcgtaaa gatatcgcgg gttatattat tatggctata
     4681 acaacagcaa ttactgcgcc cttatcattg atactggtgc gtaatgtaat aattactcag
     4741 gtcggatggg agcaggcggg acagtggcag gctgtatgga aaatttcaga agtgtatttg
     4801 agcgttatta caatagcatt aggaacttat tatttaccaa aattatctgc actgataggt
     4861 tctgagatta taattaaaga aatcaataga accgctattt acgttatccc atttgcaata
     4921 attcttgcct caatagtcta tatttttcgc gattttatta tacatatact gtttacacct
     4981 gatttcaaac cagctcgaga cttattcatg attcagcttt gtggagatgt aattaaaatt
     5041 gcgagctggt tatatgcata ccctatgtta tctcgggggg ctacaaaatg gtatgttcta
     5101 accgaaatcg tatttgcaat tacatttgta gcttttgcat ggctttttat taatattgtt
     5161 aataatgcac atggagctaa ttatgcttat ctattgaatt atgttattta cttattattt
     5221 atattgctta attttaagag aatagttcga tagcagtatt taggaaggta ttatgcagaa
     5281 attagtcgtt tatcatccaa gcaaatacct tggtggaact gaagttttgt tttcccggat
     5341 attggattta ttaatttctc gaaagtatga gaatatacat attattgatt attccgatgg
     5401 tgtattatcc tcaagatttt ataagactag tattacatat cataacgtaa ttagctatga
     5461 tgttaaagag gtgttagatg gggcagtagt gattgccagt gcaagaaata tatctcgagt
     5521 aatttatgaa agcaaacaaa ataatgtgaa gtatattaaa cctttatttt ggttattgca
     5581 tccttctgaa ctatacgcag gttattgttt gggaagtacc tttttaaaac gtctaagtta
     5641 taaattgctc tatagataca ttaagttact ccctgcaatt aaagtataca tgagtataat
     5701 taacaagctt gacttgaata ataacatatg gattatggat cgttcttgtc aacttgagag
     5761 cgagtgggct cttaattata aatttcgaga gaaagttata ttacctctta tcacaaattt
     5821 agattatcag cctgtaaaaa atattgagca ggaaagatat acgattttaa ttattagtcg
     5881 acttgatgat tttaaaatac atggaatagt gaaattactt gatgacataa ttcaatatac
     5941 gaaaaaaaat aaaagttgta aaatatctgt tcatatagtt ggtgatggta ttgcaggtaa
     6001 atttttaaag gaaaattatg ttaattccat caatatggat gtctttttcc atggctatgt
     6061 ttcaggaaaa aaattaacag agttattcca taatggtaat tactcattac tatttgctat
     6121 ggggacatct gcgcttgaag gggcgtcaag agggttacca actgtcctgt taccttgcac
     6181 agataaatct ataagaaatc gagacaatgt atatagatat ctgcatatcg ataatgatca
     6241 gggacttgga gagtatattg atacgccttt tgaaggtaca gagtatctaa cttttaatga
     6301 aatagttgag atttttaata gagataaaga aaacttggtg tgtaatacaa gaaaatattt
     6361 tttaaataat tatggaaaag aaattactca aaaaaaattt ttgttaagct tagaaaaagt
     6421 taaaattttg tccataaacg aagttaaaat ttctctaact tttcgcatat atacgaagtt
     6481 tatattgaaa aaaagactga gcactggggg tctgatactg gaataagcga aatgcctata
     6541 gctgtacatt tgattgagct agcatatgta ttaataataa tatcatttat tatcttgttt
     6601 tacatgaaaa atgtcccatt attagaggga gggtttttat tacttattat ttgttcacct
     6661 tactctattt caattatacc atttagacaa gatacaatag aactctatgg attgtatagt
     6721 aatagcgggc ttcttaattt atttaatttt tacaaagtag ccggcttatc tattttagat
     6781 ctaatagcat tactagttat agtgaaaaac tttaaattag cattgaagat gccaatcttt
     6841 tttaagtttt tttatatact aataagtttt ttttcaataa tagcttatgc aatatcagct
     6901 tatttaatat ggtctcctga actagataat gtaattcgcg ctttatctgt cttcaaatca
     6961 attatatata taataagtat ttattgtgtt attgagaaaa tttgttcacg tattggtttt
     7021 aaattatttc tcaaaatact tatgaatata atactaacat attgtattat taattgtgta
     7081 ctactaagtt ttctccccag ctggtatacg tgggtgaaat attcattcaa ttatttattt
     7141 cttgaccaaa cagatcaatt ccttgttttt ttattttgtc tgttaacttt ttgggggcca
     7201 ttaagtaagc tatatcgtta taagctgtat gcttttttat tatgtattat gctttttctt
     7261 agtggaggaa aggctggagt ctattcaata atgatattag caatgggatg gctatatcaa
     7321 aaaagtaata ttaaaggctc taatcttgga gtaattttcc tctgtgctat gatattttca
     7381 tggctattat catattttat tggagtatat gaactagata tatcaatata cagtcgttat
     7441 tttcaagtac agcaattatt tcttaattac tctaataata ttcttttggt attttttggt
     7501 attggaccct caaaagctta tattttttat gattttccaa ctatattcga tcccggagcc
     7561 tatacatcag aagagttaag ctccagtttt agattgggtt ttcaaatgcc gtatttatca
     7621 tggattaaaa actttggtct gtctggagtt atattgctat tattggcact taattatatt
     7681 attaaagtcg catggtcatt taagaaagac gatatatttt tttctggggc agtatattct
     7741 ttaggcttat attttattct aattggattc atggattttc ctgcttttgg tttaaagaca
     7801 attatcccaa taagtttata tatatatata ataaataata agctaacata taaaaaacag
     7861 gagattatat gattgttata gacggggtta ttttttcatt acaaaagtca ggaggtatat
     7921 cagtatattt ttctgaatta ttacgtcgta ttaggacaga taaggaagat gttttacatt
     7981 tactttataa taatcaaaat atttatacaa aaggctccga ttacgtagtc aatagaatag
     8041 cgcgtttaca tatttcagtt gagcggttta taaaggtcaa catatcagga acaaaaaatg
     8101 atatttttca ttcaagttat tatcgattac ctaacgcaaa atttaacgga aagattataa
     8161 cgacagttca tgatttcaca gaagaaatat atccgcgagg tttgatttca aaagttcatc
     8221 ataagcaaaa aaggcaggct attttaggta gtgatggtat tatttgcata tctaataata
     8281 cgatgaaaga tatgcataaa tttattcccg aatctgttaa cattccaact agagttattt
     8341 ataatggagt gggggatttt tctgtacgta atattgatgc caagtttgaa tcgtacgtta
     8401 tttttgtcgg ggctcgtagt ggatataaaa attttaagat gtgtgtttct gcacttagat
     8461 attttgatga tattgaattg attgttgttg gtggtggaga attctcgaaa gaagaaatta
     8521 aatttcttga tagtgagata cctggtcgtt atgttcatgc tggttttctt tctgaaaaag
     8581 aacttaatcg actctatcaa aatgctcttg cattgattta tccttcttta tatgaaggct
     8641 ttggtattcc ggtaattgag gcaatgaaat caggatgtcc tgtaattgcc tcgaagacgt
     8701 cctcagtaga ggaaatatca aatgaggcag ctattttgat cgataatatt tcagcccatc
     8761 aaattagaga ttgcattcat aatttaaaaa atccaagttt cagaatggaa aaaatagctt
     8821 taggaataga aaatgccaac ggttattctt gggacaaaat ggcattagaa acagtagatt
     8881 tttataatta tatacgaggt ttaaaatgaa ggttgcttta attacaggta ttactgggca
     8941 ggacggttcc tatcttgcgg agtttctatt agaaaaaggt tataccgtac atggtattaa
     9001 acgtcggtca tcctctttta atacagagcg tgttgatcat atctatcagg atccccatgt
     9061 taataatcca aaatttcatc ttcattatgg agatttgact gatacttcta acttgacacg
     9121 tatcttgtct gaagttaaac ctgatgaggt ttataatctc ggtgcaatga gccatgttgc
     9181 tgtatctttt gagtcaccag aatatacagc tgatgtagat gctataggta cattacgctt
     9241 gttagaggct attcgtttct taggattgga aaagaaaacc aaattttatc aggcttcaac
     9301 ttctgaattg tatggtttag ttcaagagat acctcaaaaa gagtccacac ctttttatcc
     9361 tcgctctccg tatgctgttg ctaagcttta cgcatattgg atcactgtaa attatcgtga
     9421 atcttatggt atgtatgctt gtaatggtat tttatttaac cacgaatctc cccgccgtgg
     9481 agaaactttt gttaccagaa agatcactcg tgcaattgcg aatatctctc aaggtttaga
     9541 gtcatgtcta tatcttggaa atatggactc attacgggat tggggacacg ctaaagatta
     9601 cgtaagaatg caatggatga tgctccaaca ggagtatcca gaagatttcg ttatcgcaac
     9661 aggaaaacaa atctctgtac gcgagtttgt tcgcatggct gctttagaag caggcataga
     9721 gttggagttc agtggtgtag gtgttgatga agttggaacg gtagtgaagg ttacgggaga
     9781 tagtgagaaa tatgttcgtg taggcgatga gattgttcgt gttgattctc gttatttcag
     9841 gcctgctgaa gtagaaactc ttcttggaga tccatctaaa gcgaaagata agctaggttg
     9901 ggttccagag atttctgttg aggaaatgtg tcgagaaatg gttaatagtg atcttcagaa
     9961 agctaaacag tatgctttgc tgcgagaaaa tggttttgat gtttctattt cattagagaa
    10021 ttaatttatg acgaaaagag ttttcgttgc tggccataat ggtatggttg gttctgcttt
    10081 agtaagaatg cttcaacaag agcaagatat tgagattatc actagaaaac gtaatgagtt
    10141 agatcttctt tctcaacaag ctgtaagctc tttttttaaa agtgaaagaa tagatcaagt
    10201 atatcttgct gcagcaaaag taggagggat ttatgccaat aatacctatc cggctgactt
    10261 tatttaccag aatttaatga ttgaatgtaa tatcattaac gcagcgtttc ataatggtgt
    10321 tcagaaatta ttgtttctag gatctagttg tatttacccg agagatacaa tacaacctat
    10381 acgtgaggat gcgttattaa ctggtatttt ggaaagtaca aatgaacctt atgctgtagc
    10441 caaaattgcg ggtattaagt tatgtgaatc atacaacaga caatatggct gtgattatcg
    10501 gagtgtaatg cctactaatc tttatggacc aaatgataac tttcatgctg aaaatgcaca
    10561 tgttattcct gctttactta gacgctttca tgaagccagt ttggacgaat ctgaaagtgt
    10621 tatagtttgg gggagtggta accccatgcg tgagtttctt tatgttgatg atatggcagc
    10681 agcatcggtt catgtgatga atttaccaaa ggaaatttat gataagaaca cagcgcctat
    10741 gctttctcat ataaatgtcg gcactggggt tgattgtacg attcgtgaat tagcagaaac
    10801 tatcgcctcg gtcgttaagt ttcgaggaga tattattttt gatgaatcga aaccggatgg
    10861 tacacctcga aaattattag atgtttcacg cttagctaat atgggatgga ggtggtcgac
    10921 atcgttagaa gaagggcttc aattaactta tgcttggttc ttaaaaaacc aagaaaaatt
    10981 cagaaaatag gcacttagta tgttggatta tgcgttattt aaaacgatag tagataatac
    11041 tccattgata tcaatagatc ttattattta taatgcaaaa tctgaagtat tgcttggtaa
    11101 gaggaataat cccccagcta aagcacacta ttttgttcct ggaggcagaa tatataaaaa
    11161 tgaaaaaatc acagaggctt ttcaacgtat ttgcaaagca gaaatcggtg ttgatattta
    11221 tttgcaatca gcaagatttt taggtgtttt tgaacatttt tatgaagatg catatgttgg
    11281 agaagatatt agcacgcatt atgttgtatt agcttatgaa atacatatgg acctagaatt
    11341 aaatatgtta cctttagcgc aacataatca atatgttttt atgccttctg aattgatagc
    11401 ttcgacttct gaagtccatt tttataccca gcgttatttt tgctaaaagg tcaaaatgtc
    11461 taatattata ctccctgtag tcatggctgg tggagcagga agccgactat ggccactgtc
    11521 aagagcttta tatcccaaac aattcctctc acttacatct acaaattcaa tgcttcaaga
    11581 aacgataata cgacttgaag gaatagaaca tgaatatccc ttgtttatct gcaatgaaga
    11641 gcatcgattt atagttgcag agcaactccg tcaattgagt atagatcata gtggaattat
    11701 ccttgaacct gatgggcgta atacaggtcc ggccattgcg ctagctgctt ttcatgctct
    11761 taataatgga tatgatccag taatgcttgt tcttgcagca gatcatgaga ttcaagaaag
    11821 aaaaaatttt atagattcta tagaaattgc aaaacaattt gctgaaaatg ataagcttgt
    11881 cactttcggt atagttccag cctctcctga aacagggtat ggatatataa aagttggtga
    11941 aaaaataggg cctgatggat ataaagttgc tgcatttgtt gaaaaacctc atagactttt
    12001 ggctgaagaa tacataaata gcgggaagta tctttggaac agcggaatgt ttatgtttaa
    12061 agcatctgtc tttctaaatg agttaaagaa atttcgtcca gatatttata gcatttgtga
    12121 gacttcactt ttaaagtcag agagcgatct cgattttata cgagttaatg gcaaagtatt
    12181 caattgttgc ccatcagagt caatagatta tgctgttatg gaaaatacta tgcaagcggt
    12241 agttgttccg cttgatgcaa aatggagcga tgtaggatca tggacagctt tatgggatat
    12301 tagtaagaaa aatgaaaatg gaaatattat acgcggtgat gttatagcta aagatacaga
    12361 taattgttat ttgcattcag aatcacgact tattggtacc gttggagtca aagatttagt
    12421 tatagttgaa actaaagacg cagttttagt cgcgcataaa aacaacgtac aagatgttaa
    12481 aaatatagtt gaacaattaa aaatccaaaa tcgacaagaa taccttcatc atagagaagt
    12541 ttaccgtcct tggggaagtc atgatgcagt ggctgatggt gaacgattta gggttaaaca
    12601 tgttacggta ttgcccggtc atgccatatc caaacaagtt cattaccata gagctgaaca
    12661 ttgggtaatt gtgagtggaa cagctcgtgt atatataggt gatgaaaatt ttttattggg
    12721 agaaaatgag tcgacattta ttccggtcgg gactgtacac tctattgaaa atccgggtaa
    12781 aatcccacta gagattattg aagtacaatc aggaacgtat ttgcatgaag atgatgttga
    12841 aaggtcttaa ttacttaata tattatatat tctgtagata atattgctgt tattaatatt
    12901 gtacattctt tataataact gtaattattt ttagacagca ttatggatta ctatgaaagt
    12961 aagtattatt acagctacgt ataatagtca agatacacta aaagatacat tgctatctgt
    13021 tgagcaacaa gattatcctg atatagaata tataataatt gatggaggtt cctcagatca
    13081 aactttgcag cttattaaaa aatactccac aagagttaaa tgcctaatat cggagaaaga
    13141 taatggtatt tatgatgctt taaataaggg ggttaagctt gcgaccggtg atattgtcgg
    13201 atttatacat tctgatgata tattagcaag cccacaagtt ataagtaata ttgtaaataa
    13261 gttcaaggga aatactgctg atatagttta tggtgatctc ctttttgttg atagagaaaa
    13321 acctgatatt atacatagat tttggcatag cggggaattt aagaaatcta agcttagata
    13381 tggttgggct cctccgcatc ccgcctttta tataaggcgc gcgttatata aaaaatatgg
    13441 ctgctttgat ttgaatttta aaattgcagc tgattatgat cagatgcttc gtttattact
    13501 agtaccttac ttacaaatca tctatgtacc agaagtcttt gttaaaatga gacttggtgg
    13561 agaaagtacg aagttaaata atgcgctttt aagtactaaa gaaataattg cgataatgcg
    13621 taagcataat ataaattggc aagtagcaat attgacgaga aagttaagta aactttggca
    13681 aattttttcg aaatttaaaa ggtcaaatat ttcatgaaaa aactaccttg tttcaaggcc
    13741 tacgacattc gcggcaggct gggcgaagag ctcaatgaag atatcgcgtg gcggattggc
    13801 cgcgcctacg gcgaatattt aaaaccgaaa accatcgtgc taggcggcga cgtgcgcctg
    13861 accagcgagg cgctgaagct ggcgctggcg aaagggttac aggacgcggg cgtcgacgtg
    13921 ctggatatcg gtatgtccgg caccgaagag atttacttcg ccaccttcca cctcggcgtg
    13981 gacggcggta ttgaggtgac cgccagccat aacccgatgg actacaacgg catgaagctg
    14041 gtacgcgagg gcgcccgccc gataagcggc gacaccggtc tgcgcgacgt tcagcgtctg
    14101 gcggaagcgg gcgacttccc gccggtgaac gaggccgcgc gcggcagcta cagacaaatc
    14161 agcctgcgcg acgcctacat cgaccacctg ctggggtata tcagcgtcag caatctcacc
    14221 ccgctgaagc tggtggtgaa ttccggcaac ggcgcggcgg ggccggtcat tgacgccatc
    14281 gaagcgcgcc tgaaggcgct gggcgcgtcg gtggagttca tcaaaatcca caacaccccg
    14341 gacggcacct tcccgaacgg cattcccaac ccgttgctgc cggagtgtcg cgacgacacc
    14401 cgcaaggccg ttattgaaca cggggcggac atgggtatcg cctttgacgg cgacttcgac
    14461 cgttgcttcc tgttcgatga gaaagggcag tttatcgagg ggtattacat cgtcgggctg
    14521 ctggcggaag cgtttctgga aaaacacccg ggggcgaaga ttatccacga cccgcgcctg
    14581 acctggaaca cggaggcagt ggtgacggcg gcgggcggga cgccggtgat gtcaaaaacc
    14641 gggcacgcct ttatcaagga gcggatgcgt acggaggatg ccatttatgg cggggaaatg
    14701 agcgcgcatc actatttccg tgattttgcc tactgcgaca gcgggatgat cccgtggctg
    14761 ctggtggcgg agctggtgtg cctgaaaggg cagtcgctgg gtgaactggt ccgcgaccgg
    14821 atggcggcgt tcccggcgag cggggaaatc aacagcaggc tggcggagcc ggcggcggcc
    14881 attgcgcggg tggaatcgca ctttgcggaa gaggctcagg cggtggatcg cacggacggt
    14941 ctcagcatgt cattcccgga ctggcgtttc aacctgcgct cgtcgaacac cgaaccggtg
    15001 gtgcgcctga atgtggaatc caaagcaaat acagaattga tggaagaaaa aacgcaagca
    15061 atcctgacat tattacggaa atagtttttc gtgtgacata catatagagt tattccatag
    15121 tcaattcatt tatgcaatca atgcgatacg aatccgtaaa agctatccat attttccaat
    15181 tctgagttaa catctaagcc acatttcaag ccgcgctctc gtcgcgcggt gaccacacct
    15241 gacaggagta tgtaatgtcc aagcaacaga tcggcgtcgt cggtatggca gtg
//
