LOCUS       GU356399               11688 bp    DNA     linear   BCT 08-JUN-2010
DEFINITION  Salmonella enterica serogroup O55 O-antigen gene cluster, complete
            sequence.
ACCESSION   GU356399
VERSION     GU356399.1
KEYWORDS    .
SOURCE      Salmonella enterica
  ORGANISM  Salmonella enterica
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Salmonella.
REFERENCE   1  (bases 1 to 11688)
  AUTHORS   Liu,B., Perepelov,A.V., Svensson,M.V., Shevelev,S.D., Guo,D.,
            Senchenkova,S.N., Shashkov,A.S., Weintraub,A., Feng,L., Widmalm,G.,
            Knirel,Y.A. and Wang,L.
  TITLE     Genetic and structural relationships of Salmonella O55 and
            Escherichia coli O103 O-antigens and identification of a
            3-hydroxybutanoyltransferase gene involved in the synthesis of a
            Fuc3N derivative
  JOURNAL   Glycobiology 20 (6), 679-688 (2010)
   PUBMED   20147450
REFERENCE   2  (bases 1 to 11688)
  AUTHORS   Liu,B., Perepelov,A.V., Svensson,M.V., Shevelev,S.D., Guo,D.,
            Senchenkova,S.N., Shashkov,A.S., Weintraub,A., Feng,L., Widmalm,G.,
            Knirel,Y.A. and Wang,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-DEC-2009) TEDA School of Biological Sciences and
            Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin
            300457, P.R. China
FEATURES             Location/Qualifiers
     source          1..11688
                     /organism="Salmonella enterica"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:28901"
                     /note="serogroup: O55"
     gene            107..1180
                     /gene="rmlB"
     CDS             107..1180
                     /gene="rmlB"
                     /note="RmlB"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase"
                     /protein_id="ADI39336.1"
                     /translation="MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLS
                     DISESNRYNFEHADICDKAAMEHIFAAHKPDAVMHLAAESHVDRSITGPADFIETNIV
                     GTYVLLEAARGYWNELNADKKLAFRFHHISTDEVYGDLPHPDEVQAGSTLPLFTENTA
                     YAPSSPYSASKASSDHLVRAWLRTYGFPTIVTNCSNNYGPYHFPEKLIPLVILNALEG
                     KALPIYGRGDQIRDWLYVEDHARALYTVVTKGVVGETYNIGGHNEKKNLDVVHTICDL
                     LDEIVPKEGSYRDQLTYVADRPGHDRRYAIDADKISRELGWKPLETFESGIRKTVEWY
                     LNNRAWCQRVQDGSYQRERLGLE"
     misc_feature    107..11535
                     /note="O-antigen gene cluster"
     gene            1182..2051
                     /gene="rmlA"
     CDS             1182..2051
                     /gene="rmlA"
                     /note="RmlA"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="ADI39337.1"
                     /translation="MKGIILAGGSGTRLYPITMGVSKQLLPIYDKPMIYYPLSVLMLA
                     GLKDILIITTPEDQDGFIRLLGDGSQFGINLSYAIQPTPDGLAQAFIIGEEFIGQDSV
                     CLVLGDNIFFGQGFTPKLKAAAERKSGATIFGYQVMDPERFGVVEFDEDFKALSIEEK
                     PSCPKSNWAVTGLYFYDNNIIDIAKSIKPSARGELEITTINEVYLKNNALTVELLGRG
                     FAWLDTGTHDSLIEAGSFVETVQKRQGMMVACPEEIAWRNGWLSNSELISKGEFLIKN
                     HYGKYLLRLIKGH"
     gene            2059..2448
                     /gene="fdtA"
     CDS             2059..2448
                     /gene="fdtA"
                     /note="FdtA"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-6-deoxy-D-xylo-hex-4-ulose
                     3,4-ketoisomerase"
                     /protein_id="ADI39338.1"
                     /translation="MKLIQLSKKEDHRGALVVVEQHRDIPIEIKRVYYMFDTDTNVRR
                     GFHAHKRLTQVAISIKGSCKFLLDDGEAVEHVLLDSPSAGLVIEPMVWHEMYDYSDDC
                     ILMILADDYYDEDDYIRNYEQFKSMVK"
     gene            2449..2904
                     /gene="fdtC"
     CDS             2449..2904
                     /gene="fdtC"
                     /note="FdtC"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-Fuc3N acetyltransferase"
                     /protein_id="ADI39339.1"
                     /translation="MFIHKFSDVHSSKIGKNTRVWQFSVILENAIIGEDCNICAHTLI
                     ENDVSIGNRVTIKSGVYIWDGITIEDDVFIGPCVTFTNDKKPKSKKYPEKFSRTIIKK
                     GASIGANATILPGITIGEGAMIGAGSVVTKDVPANITVIGNPAKAVKEK"
     gene            2906..4009
                     /gene="fdtB"
     CDS             2906..4009
                     /gene="fdtB"
                     /note="FdtB"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-6-deoxy-D-xylo-hex-3-ulose
                     aminotransferase"
                     /protein_id="ADI39340.1"
                     /translation="MIDFLNLKRINNKYEKELKDACARVIDSGWYIMGKELDSFESNF
                     SEWCNVKNTVGVANGLDALILVLRAWIELGKLEAGDEVIVPANTYIASILAITENKLM
                     PVLIEPDPVTFNICPENIKKAITNKTKVILPVHLYGQICPMDIIMDIAKENNLLVLED
                     SAQAHGASINGIKAGAWGHASGFSFYPGKNLGALGDAGAITTNDDELAQVVRALRNYG
                     SHKKYENYYKGINSRLDEIQAAMLNVKLKYLDEDINIRRKIAEQYLEKIINPNIQLPA
                     IKDASNHVWHLFVVKTEERLLLKDYLDKHNIQSLIHYPIAPHHQKAYEELKSLDLPIA
                     ELLHKNVLSIPMDPTMTQLEVDSVIDVLNGWKI"
     gene            3997..5277
                     /gene="wzx"
     CDS             3997..5277
                     /gene="wzx"
                     /note="Wzx"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="ADI39341.1"
                     /translation="MENLNFAKITILSGIITCLRLVCGLLISKVVAIYTGPAGISNLG
                     QLQSFVTFVNGFISSQVSQGVNRYSAEYKYNYNEAQKYWRAAAKLSAIACCFIMCLGI
                     FSSGYLADYLFHNRSLFWLIIVALLVLPLNIINNIFLGVLNGLGDYNKFFIANVFAII
                     SSVLSMTGLVYFLGLKGALISAALNNAIAGVWLVLIILKRPWFNFKYWIGSVPKEQLA
                     DMGKYFLMGIIGALTGPISMIIVRTILTNNFSIEYSGYWQAVTKISEAYLAVLTTAMT
                     VYYFPKTASAKTVSEHIAILLTGVKIVVPLSFLMAFTIFQLKDFIISLLFTREFHTAR
                     ELFLFQNIGDFLRICSWLFATILLAKGYFIINATLEISVSILFPVLVKLLITHFGLSG
                     ASIAYCATYFIYLICTAFVYYWHIKFKVREDHAA"
     gene            5267..6271
                     /gene="wdbT"
     CDS             5267..6271
                     /gene="wdbT"
                     /note="WdbT"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ADI39342.1"
                     /translation="MRLDRDVLSIIIPAYNEERNIEKILGLLEKQTIEGFEVIVVDDG
                     STDNTPLLVSSYVPTKYSLVLLQQQNRGAAYAREIAINKSCSRFIAVIDCDDSIANDT
                     LEKAIKPLLNSKVIDISLFKLNYVNNVGGEILKVFTYYTKNKILDGRDVFNNCIRFWG
                     VHAFGIYKRERILHSYAIYHELNRDKKNYLNNDEVISRITFDISNRIIITDADYFFVN
                     NLQSTTRRINKNYFKVINNVFLLKRYIENKKETRQSLHVMTDIQALSISTVWGVTVRY
                     LKWRKFLNKTEQLQWQELISTASIQLISAGKEHNISISIKNKLQLIIIRCLTRKWILC
                     "
     gene            6256..7140
                     /gene="wdbU"
     CDS             6256..7140
                     /gene="wdbU"
                     /note="WdbU"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ADI39343.1"
                     /translation="MDTMLVTIIIACYNAEQYIQDTLDSCINQTYSNVQIIIADDCSK
                     DNSVNIINNWIEARRKTHPHTECILITNDKNRGIPANFNNGLRYAKGEWIKCLGSDDL
                     LVADAISKFVERIELEPYKVNTGAIFTYFETFGDVNISHRYPLAWTKWISAMQPSAFK
                     RCMANIHFNNLAPGAFINKAFLESFDTNYWLLEDLPLWLKLINADVRTSFYDIVSVKY
                     RIHARQVTALGTRNNEILFNDLKKLNKIRLKNKHIIAYMHNKFNLYCIGKRKYLKILN
                     PINIFIKLIEKGFSKCLF"
     gene            7128..8255
                     /gene="wzy"
     CDS             7128..8255
                     /gene="wzy"
                     /note="Wzy"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="ADI39344.1"
                     /translation="MFVLINVFILLFFSCFWGRFDFKSKVILRFLIWSGLVFSFSSFY
                     INGVDWTVYFSKFSYEDNYYLFLSFEPGFVIFLKALLFLTYGNFGGAIFCFFMITFGF
                     LMYSLEKYKINEPLFLAGLILACGYTLILEQLRQFIACLIVFVFLINYNKNKSLVRLI
                     FGVTIASFFHISALVVIPAVILCNIKNRFVFIVTTIIFGILFVLFLFFGLYILEQIPQ
                     FAFVVRKINFYLEQNPTILQLGWLNLFVLIYTVAYVFFSYSIERNSNANLLNRFIFVG
                     SIIFIFSGTFPFLGRMTLYFIFIALYIISDPKKNWRIGNAIVVNGYFSIFLVLNFSSY
                     FRNDLAPVDFDNLNYCFLNLFDNNYMQKIATENLPEMLVGE"
     gene            8257..9363
                     /gene="wdbV"
     CDS             8257..9363
                     /gene="wdbV"
                     /note="WdbV"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ADI39345.1"
                     /translation="MNAAKPKLLFIITGLGLGGAERQLCDLADGFYHRNCDVKIISLT
                     GNGICRPAEKNINIVSLGLSKNPLSFLRTYIQARKIIKIYRPDVIHSHMYHANIFSRL
                     LRLTVRIRYLITTAHNKNEGGRGRMLAYRMTNFLSDITTNVSQEAVDSFISQGAFNKN
                     DIIPIYNGIDINKFHYDSSWRDYIRNTLGIEPKTPLLVAVGRLTEAKDYPNLLNAFSL
                     VNVNPLPVLAIVGTGTLESSLKELAKELKVENRVFWLGARHDVEKWYSACDLFILSSQ
                     WEGFGLVVAEAMASEALVVVTDAGGVAEIVDDSEFVVPTSNSLALAKKINQVLTYDKV
                     KVDKIRKDNRRKIVEKFSLESAIQKWLSLYKVEQ"
     gene            9360..10481
                     /gene="wfbG"
     CDS             9360..10481
                     /gene="wfbG"
                     /note="WfbG"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="ADI39346.1"
                     /translation="MKVLLIGNISDTIILFRQHLIIKLIEKGNSVYTLTMDNNPDNFA
                     RIRKYGAIPKSYFFSRSGINPFVDIINTYKLSKEIKNIKPDIVLCFFPKPVIYGTIAA
                     KIAGVKSIYNLLEGLGFCYTQSLGRESFKKIFLKKIQTLLYKFSLPLANKILFLNADD
                     YRDLILENNIRIKDFEVIGGIGVNLKNYTYMQPDISAIHFGMVSRLLIEKGVREFVEA
                     ARFVKTIYPQVKFSIAGAVDDNPGGISREQVATWEKEGVVKFLGQVSDINEYLSNINI
                     FVLPSYREGIPRSTQEAMAMGLPVITTDVPGCRETVKNEVNGLVVPPWDAEALVEAMT
                     FFIANPEKIIAMGKQSRIMAEEKFDENEATSKLLRVFFN"
     gene            10516..11535
                     /gene="gne"
     CDS             10516..11535
                     /gene="gne"
                     /note="Gne"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-GlcNAc-4-epimerase"
                     /protein_id="ADI39347.1"
                     /translation="MAILVTGGAGYIGSHTVLTLLEKGKKVVVIDNLSNSSYISLCRI
                     KEITGIEPTFYKGDILDKSILRKIFSENNITDVIHFAGVKSVGESVLLPLKYYKNNIS
                     GTLCLLEEMVSFGVNNFIFSSSATVYGEPEMIPLTESCEIGGTTNPYGTSKLFVEKIL
                     EDFAAAHSNFRINILRYFNPVGAHSSGKIGEDPNGIPSNLMPYICQVAIGKHSHVSVF
                     GCDYPTTDGTGVRDFIHVMDLAEGHVAALEYKNDGPNLKIYNLGTGRGYSVLELLKTF
                     ERMTSIPVPYVFAERRVGDIAECWSDPTKARVELGWKAKRKLEDMIRDAWNWQMKNPN
                     GYDVN"
BASE COUNT     3663 a   1749 c   2361 g   3915 t
ORIGIN
        1 attggtagct gtaagccaag ggcggtagcg tgtgtaacga cttgagcaac tacattatta
       61 ttggcaaatt aaatgccgta ttaaatacgc cttatggaat agaaaagtga agatacttat
      121 tactggcggg gcaggtttta ttggatctgc tgttgttcgc catatcatta agaatacaca
      181 ggacactgta gttaatattg ataaattaac ctacgccggt aatcttgaat ccctttctga
      241 tatttctgaa agtaatcgct acaattttga acacgcggat atttgtgata aagcggctat
      301 ggagcatatt ttcgccgcgc ataaaccaga tgcagtaatg catctggctg ctgaaagtca
      361 tgttgatcgc tctattactg gtcctgcaga ctttattgaa acgaatatcg tcggcactta
      421 tgtattactc gaagccgctc gtggctactg gaacgagttg aatgcagata agaaactggc
      481 atttcgtttc catcatatct ccacggatga agtatacggc gacctgccac atcccgacga
      541 ggtacaagcc ggtagcactt tgccgttgtt tacggaaaat acggcctatg caccgagcag
      601 cccgtactcg gcttctaaag cctccagcga tcacctggtt cgcgcatggt tacgcaccta
      661 tggttttccg acaatcgtca ccaactgttc caacaactat ggcccgtatc acttccctga
      721 gaagctgatt ccgctggtga tcctgaatgc acttgagggt aaagcattgc caatttatgg
      781 cagaggcgat cagattcgcg actggttgta tgttgaagat catgcccgag cgttatacac
      841 cgttgtgact aagggcgttg taggtgaaac ctacaatatt ggtgggcata acgagaagaa
      901 aaatctggac gtggtccata ctatctgcga cttgttggac gagatagtgc caaaagaagg
      961 ttcttaccgc gatcaactta cctatgtagc cgaccgccca ggacacgatc gccgctatgc
     1021 gattgatgca gataaaatta gtcgcgaatt aggctggaaa ccgctggaga cctttgaaag
     1081 cggcattcgt aaaaccgtgg agtggtattt aaacaataga gcatggtgcc aacgtgtaca
     1141 agatggtagc tatcagcgtg aacgtttagg gctagaataa gatgaaaggc attatattag
     1201 caggtggttc aggaaccagg ctttatccta tcactatggg agtatccaaa cagttacttc
     1261 ccatttacga taagccaatg atttattatc ctctctcagt tttgatgctg gctggtttaa
     1321 aagatatttt gattattact actccagagg atcaggatgg ctttatccga cttctcggcg
     1381 atggtagcca atttggcatt aatttatctt atgctattca gccgacacct gatgggctcg
     1441 cccaagcgtt tattattggt gaagagttta tcggccagga ttctgtttgc cttgttttgg
     1501 gagataacat cttttttgga caggggttta caccgaaatt gaaggctgca gccgaaagaa
     1561 aatcgggcgc tactatcttt ggttatcagg ttatggaccc tgagcgtttt ggtgtagttg
     1621 aattcgatga ggattttaaa gcactaagca ttgaagaaaa accatcctgc cctaaatcaa
     1681 attgggccgt taccggactt tatttttatg ataacaatat catagatatt gcaaaatcaa
     1741 ttaaaccgtc agctcgcggt gaactggaga ttacaacaat taatgaagtt tatcttaaaa
     1801 acaatgccct gacggttgaa cttttaggcc gtggcttcgc atggcttgat actggaacac
     1861 acgatagcct aatagaagct ggtagctttg ttgagacggt tcagaaacgg caaggaatga
     1921 tggtcgcatg tccagaagag attgcttggc gtaatggttg gttaagtaat agcgaattga
     1981 tttcaaaagg agagttctta ataaaaaatc attatggaaa atatttgctt agattaatta
     2041 aaggtcatta aaagaaaaat gaaattaatt cagttaagta aaaaagagga tcatcgagga
     2101 gctttggttg ttgttgaaca acatagagat attcctatcg aaatcaaacg agtctattat
     2161 atgtttgata cagatactaa tgtcagacgt ggttttcatg cgcataagag attaactcaa
     2221 gtagcaattt caataaaagg ttcatgtaag tttttacttg acgatggtga agcggtcgag
     2281 catgttttat tggattctcc atccgcaggg ttagtcatag aaccaatggt ttggcatgaa
     2341 atgtacgatt attctgatga ctgcatttta atgattcttg ctgatgacta ctatgatgag
     2401 gatgattata tccgcaatta tgagcagttt aaatcaatgg taaaataaat gttcatacat
     2461 aagtttagcg atgtacattc atcaaaaatt gggaaaaaca caagagtatg gcaattctct
     2521 gttattctgg agaacgctat aataggtgag gattgtaata tttgtgccca tacattaatc
     2581 gaaaatgacg tttcaattgg aaatagagtt acaattaaat ccggggttta tatatgggat
     2641 ggtattacta ttgaagatga tgtgtttatt gggccatgtg ttacctttac taatgataaa
     2701 aaacccaagt ctaaaaaata tccggaaaaa ttttctcgca caataataaa aaaaggtgcc
     2761 tcaataggtg caaatgcaac gatcttacca ggtattacga ttggtgaagg tgcaatgatt
     2821 ggtgccggtt cggttgttac gaaagatgtg cctgcaaata ttacagttat tggaaaccca
     2881 gcaaaagcgg tcaaggagaa gtagcatgat tgattttctt aatttgaaaa gaattaataa
     2941 taaatatgaa aaagagttga aagatgcctg tgctcgcgtt atcgattcag gttggtatat
     3001 tatggggaaa gaactggata gtttcgaaag taatttttct gaatggtgta atgtaaaaaa
     3061 taccgtaggt gtggcaaatg gccttgatgc tttaattctg gtattgaggg cctggattga
     3121 gttaggtaaa ttggaagcgg gtgatgaagt tattgtacca gcgaacacgt atattgcatc
     3181 tattcttgca ataactgaaa acaaacttat gccagtgcta attgagccag atccagttac
     3241 ttttaatatt tgtcctgaaa atattaagaa agcaataaca aataagacaa aagtgatact
     3301 tcctgttcat ttatatgggc agatatgtcc aatggatatt ataatggaca tagcaaaaga
     3361 gaataaccta cttgttttag aggatagtgc ccaagctcat ggtgcttcaa tcaatggtat
     3421 aaaagcaggc gcatggggac atgcttcagg ctttagcttt tatccaggaa agaatctggg
     3481 ggctttaggt gatgctggcg ctatcacaac gaatgatgat gaactggctc aagttgttcg
     3541 tgcactgcgt aactatggtt ctcataagaa atatgaaaat tattataaag gcattaatag
     3601 tcgccttgat gaaattcagg cagcgatgtt gaatgttaaa ttaaaatact tagatgaaga
     3661 tattaatatt cgtcgtaaga tcgcagaaca atacttagaa aaaataatta atccgaatat
     3721 tcaattgcct gcaataaaag atgcatcgaa tcatgtctgg catttatttg tggttaaaac
     3781 agaagaaaga ttattattga aagactattt agataaacat aatatacaaa gtcttatcca
     3841 ttatccaatt gcacctcacc atcaaaaagc atatgaagaa ttaaaatcac tcgatttacc
     3901 aattgctgag ttgctccata aaaatgttct atctattcca atggacccaa caatgacaca
     3961 attagaagtt gatagcgtta ttgatgtctt aaatggatgg aaaatttgaa ttttgcaaag
     4021 ataacaatcc tgagtggcat aatcacttgc ttgaggttgg tttgcggact tctcatatcg
     4081 aaagtagttg caatctatac tgggccggct ggaatatcta acttaggaca attacaaagt
     4141 tttgtaacat ttgtcaatgg attcatatca tcacaagtat cacagggagt aaatcgctat
     4201 tctgcggaat ataaatataa ttataatgaa gcacagaaat attggcgagc agcggcaaaa
     4261 ctgtcagcta ttgcatgttg ctttatcatg tgcttgggga ttttttcatc cggttattta
     4321 gctgactact tatttcataa tcgaagcctt ttttggctaa tcatagtggc cttattagtt
     4381 ctgcctttaa atataattaa taatatattt ttgggagttt taaatggatt aggcgattat
     4441 aataagtttt ttattgcgaa tgtttttgca attatatcat cagtcctgtc gatgacaggg
     4501 cttgtttatt ttcttggctt aaaaggggca ctcatttctg ctgcgttaaa taatgcgatt
     4561 gcaggagttt ggctggtttt aataatatta aagcgacctt ggtttaattt taaatattgg
     4621 attggttctg ttcctaaaga acaacttgct gatatgggaa agtattttct tatggggata
     4681 ataggtgctc ttactggccc tatttctatg atcattgtgc gaaccatttt gacaaataat
     4741 ttttccattg aatactcagg ttattggcaa gcggtgacta agatttccga ggcttatctt
     4801 gctgtgctaa ctacagcgat gactgtttac tattttccca aaacagcatc ggcgaaaaca
     4861 gtttctgaac atattgctat tttattgaca ggcgtaaaaa ttgttgtacc attatcattt
     4921 ttaatggcat ttactatttt tcagttaaag gatttcatta ttagtttgtt attcacacgt
     4981 gaatttcata cggcccgtga gctttttctc tttcaaaata taggtgattt tttacgaatt
     5041 tgtagttggc tatttgcaac tatacttttg gcaaaaggtt attttataat aaatgcaaca
     5101 ctggaaattt ctgtttctat tctattccct gtattggtga aactcctgat tactcatttc
     5161 ggtttgtcgg gcgcaagtat agcgtattgc gctacatatt tcatctattt aatatgtact
     5221 gctttcgtat attattggca tataaaattt aaagtgagag aggatcatgc ggcttgatag
     5281 ggatgttttg agtattatta tcccagctta taatgaagaa cgtaatatag agaaaatatt
     5341 aggtctactt gaaaaacaaa caatagaggg gtttgaagtt atagtagtgg atgatggttc
     5401 gactgataat acaccattat tagtgagtag ctatgtacct actaaatatt ctttagtcct
     5461 tttacaacag caaaatagag gtgcggctta tgccagagaa attgcaataa ataaaagttg
     5521 ttctcgattt atagctgtta ttgattgtga tgatagtatt gctaatgata cacttgaaaa
     5581 agcaatcaaa ccgctattga acagtaaggt tatcgatatc tcgttgttca aactgaatta
     5641 tgtcaataat gttggtggtg aaatattaaa agtatttact tattacacta aaaataaaat
     5701 attagacggt agggatgttt tcaataactg cataaggttt tggggggttc atgcttttgg
     5761 catctataag agagagcgta ttctccattc ttatgctata tatcatgaat taaatcgcga
     5821 caaaaaaaat tatttgaata atgatgaggt tatctcaaga attacttttg atatctcaaa
     5881 taggataatt attacggacg cagattattt ctttgtaaat aatttgcagt caaccaccag
     5941 acgtataaat aagaattatt ttaaggttat taataatgtg tttttgctaa aaagatacat
     6001 tgaaaataaa aaagagactc ggcaatcttt acatgttatg actgatattc aggctttatc
     6061 catcagtacc gtttgggggg ttactgtaag atatcttaaa tggagaaaat ttctgaataa
     6121 aactgaacaa ttgcagtggc aagaattaat cagtacggcc tctattcagc tcattagtgc
     6181 tggtaaagag cataatatat cgatcagtat taaaaataaa ttacaactga ttattattag
     6241 atgtttaact agaaaatgga tactatgtta gtaactatca ttatagcttg ttataacgcg
     6301 gagcaatata tacaagatac gcttgattct tgtataaatc agacctatag caatgtgcag
     6361 ataattattg ctgatgattg ctcaaaggat aacagtgtta atattattaa taactggata
     6421 gaagcaagac ggaaaaccca tcctcatact gaatgtattc ttattactaa tgataaaaat
     6481 agaggcattc ctgcaaattt taataatgga cttaggtatg ctaaaggaga atggataaaa
     6541 tgtttgggat ctgatgattt attggttgcc gatgccatta gtaaatttgt cgaacgtatt
     6601 gagcttgaac cgtataaagt aaatacaggc gctattttta cttattttga aacttttggt
     6661 gatgttaaca tttcgcacag atacccattg gcatggacta aatggattag tgctatgcag
     6721 ccttctgcat ttaagagatg tatggcaaat attcatttca ataatttagc tccaggtgcc
     6781 tttattaata aggcattttt agagtccttt gatactaatt attggcttct ggaagattta
     6841 cctttgtggt tgaagttgat aaatgctgat gtgcgaacca gtttctatga cattgtctct
     6901 gtgaaatatc ggattcatgc aaggcaagta acagccttag gtactcgaaa taatgaaata
     6961 ttatttaatg atttaaaaaa attaaataaa ataagattaa aaaataaaca tattattgca
     7021 tatatgcata acaaatttaa tttatattgc atagggaaaa gaaaatattt aaagatattg
     7081 aatccaatta atatatttat taaattaatt gagaaagggt tttctaaatg tttgttttaa
     7141 taaatgtatt tatcttgttg tttttttctt gtttttgggg acgttttgat tttaagagta
     7201 aagtcattct taggtttcta atatggtcag ggttagtatt ctctttttct tcattttata
     7261 tcaatggtgt tgattggact gtttatttca gcaaatttag ttatgaggat aattattatt
     7321 tatttttgtc atttgaacct ggttttgtca tctttttaaa agcattgctg ttcttgactt
     7381 atggtaattt tgggggggct attttttgtt ttttcatgat tacatttggt tttctaatgt
     7441 actcattaga aaaatataaa attaatgaac cgctgtttct tgctggatta atattggcat
     7501 gtggatatac actgatactt gagcagctta ggcaatttat agcatgtctt attgtttttg
     7561 tttttcttat taattataat aaaaataaat ctttagttag attaattttt ggtgtgacaa
     7621 ttgcttcatt ttttcatatt tctgcacttg tggtaattcc tgccgttatt ctatgtaata
     7681 ttaaaaatcg atttgtattt attgttacaa caattatttt tggtattctg tttgttttat
     7741 ttttattttt cggtttatat atactggagc aaattccaca atttgctttt gtagtccgga
     7801 aaattaattt ttatctggaa caaaacccaa cgatcttaca actgggatgg ttgaatttat
     7861 tcgtgcttat ttatacggta gcttatgttt tttttagcta ttctatagaa agaaactcga
     7921 atgctaattt attgaatcgt tttatttttg ttggttctat aatttttatt tttagtggaa
     7981 cattcccttt tttggggcgg atgacgcttt atttcatatt tatcgctctt tatataatct
     8041 cagatcctaa aaagaattgg cgaattggta atgcgatagt agtaaacgga tatttttcta
     8101 ttttcttggt gttgaatttt tcttcatatt ttcgtaatga tttagcaccc gtagactttg
     8161 ataatttaaa ttattgtttt ttaaatttgt ttgataataa ctatatgcag aaaatagcga
     8221 ctgaaaattt acctgaaatg ttagttggag aataaaatga atgccgctaa gccaaaattg
     8281 ctttttataa ttacaggtct gggattaggt ggtgctgaac gacaattgtg tgatcttgct
     8341 gatggatttt accatcgaaa ttgtgatgta aagattattt ctcttactgg taatggaatt
     8401 tgccgccctg ccgaaaaaaa tataaatatc gtatcgttag gattgtcaaa aaatccactc
     8461 tcttttttaa ggacatatat tcaagctcgt aagataatta aaatatatag acccgatgtt
     8521 atccatagtc atatgtatca tgcgaatata ttttcacgtt tgcttcgctt aactgtaagg
     8581 attcgctatt taattactac tgctcataat aagaacgaag gtggtcgagg gcgaatgctg
     8641 gcttatcgta tgacaaattt cttgagtgat ataactacta atgttagtca ggaggcagtt
     8701 gattccttca ttagtcaagg tgcatttaac aaaaatgata ttatcccgat ttataatggt
     8761 attgatatta ataagttcca ctatgattct tcatggagag attatatacg aaacacgctg
     8821 ggtatcgaac caaaaacacc attattggtt gccgtaggaa gattaactga agctaaagat
     8881 tatcctaatt tactgaatgc tttctcatta gttaacgtga atcctttgcc tgttctggca
     8941 atagttggta caggaactct tgaaagttca ttaaaggaac tggcaaaaga attaaaagtt
     9001 gaaaaccgag tgttttggtt aggtgcgcgg catgatgttg aaaagtggta ttctgcttgt
     9061 gatctattta ttttatcttc tcaatgggaa ggatttgggc ttgttgttgc ggaagcaatg
     9121 gcaagtgaag cattagttgt agttaccgat gctggtggtg ttgctgaaat agttgatgac
     9181 agtgaattcg tcgttccaac ttcgaatagt ttagcactgg ccaagaagat taatcaggtg
     9241 cttacgtatg acaaagttaa agttgataag ataagaaaag ataatagaag aaaaatagtt
     9301 gaaaagtttt ctctggaaag cgccattcag aaatggttat ccttatataa ggtagagcaa
     9361 tgaaagtcct tttaattggt aatatatcag atactattat tcttttcaga caacatttaa
     9421 taataaagct aatcgaaaaa ggtaattctg tatatacttt gactatggat aataatcctg
     9481 ataattttgc aaggatacgt aaatatggag caataccgaa atcctatttt ttttctcgtt
     9541 ctggaattaa tccttttgtt gatattatta atacctataa actatcaaaa gaaattaaaa
     9601 atattaaacc tgatatagtc ctgtgctttt ttcctaagcc agttatttat ggtacaattg
     9661 ctgctaaaat agcaggcgtg aaaagtattt ataatctcct ggaggggttg gggttttgtt
     9721 atacccaatc tctggggcgg gaatctttca aaaaaatctt tttaaaaaag atacagacgt
     9781 tgttatataa attttcttta cctctggcga ataaaatcct ttttttaaat gctgatgatt
     9841 accgagatct cattttggaa aacaatatcc ggattaagga ttttgaagta atcggtggca
     9901 ttggtgttaa cctcaaaaat tatacgtaca tgcaacctga tattagcgca atccattttg
     9961 gtatggtttc acgtctttta attgaaaaag gtgtgagaga atttgttgag gctgccaggt
    10021 ttgttaaaac gatatatcca caagttaaat ttagtatcgc tggcgcagtg gatgacaatc
    10081 ctggtggaat atctcgcgaa caagttgcaa cttgggaaaa agaaggcgtt gtaaaatttt
    10141 tagggcaagt ttctgatata aatgagtacc ttagcaatat aaacattttt gttttgccat
    10201 catatcgtga aggaatcccg cggagtacgc aggaagcaat ggccatgggt cttcctgtta
    10261 ttactactga tgtacccgga tgccgtgaga cggttaaaaa tgaagtaaat ggattagttg
    10321 ttccaccatg ggatgcggag gcgcttgttg aagcaatgac tttttttata gctaatccag
    10381 aaaaaataat agcaatgggg aaacaaagca gaattatggc tgaagaaaag tttgatgaga
    10441 atgaagcaac tagcaagtta ctccgggtct tttttaatta aggtttaaca aaatatcata
    10501 agagcggagt tgtctatggc tattcttgtt acaggtggtg ctggttatat tgggtcgcat
    10561 actgtgctaa cactacttga aaaaggtaaa aaagtagttg tcattgataa tctatcaaat
    10621 tcctcgtata tatcattatg cagaatcaaa gaaattaccg gtattgagcc taccttttat
    10681 aagggagaca ttttagataa atcgattctg agaaaaatat tctcggaaaa taatattact
    10741 gatgtcattc attttgctgg tgtaaagtca gtaggagaat cggttttatt gccattgaaa
    10801 tattataaaa ataatatttc aggtacgctt tgtctcttag aggaaatggt aagttttggg
    10861 gttaataatt tcattttcag ttcatctgca actgtatatg gtgaacctga aatgatccca
    10921 ctcactgaga gttgtgagat tggtggaaca acaaatccct atggtacttc aaagttattt
    10981 gttgaaaaaa ttttagaaga ttttgctgct gcacattcta atttccgtat taatatcctt
    11041 agatacttta atccagtagg tgcacattca tcaggtaaaa ttggtgaaga tccaaacgga
    11101 atacccagca atcttatgcc ttacatttgc caggttgcta tcggcaaaca tagtcacgtg
    11161 tcggttttcg gttgcgatta ccctacaaca gatggaactg gggttcgtga ttttatccat
    11221 gtgatggatt tggctgaagg tcatgttgct gccttagaat ataaaaatga tgggccaaat
    11281 ctaaaaatct ataatttagg aaccgggagg ggctattcag ttcttgaact tttaaaaaca
    11341 tttgaacgta tgacctcgat tcctgtgcca tacgtattcg cagaacggcg agttggtgat
    11401 attgcagaat gttggtccga cccaactaaa gctcgcgtag aacttggttg gaaagctaaa
    11461 cgaaaacttg aagatatgat tagagatgcc tggaactggc agatgaagaa tcccaatggt
    11521 tatgatgtta actaaatttt aatgtatgtt ttggattgtt ggttaccaga aacgcatgtc
    11581 ctgcgttaag atagcatcta catcaatatg cattgtgtat catagtacca cacctgacag
    11641 gagtatgtaa tgtccaagca acagatcggc gtcgtcggta tggcagtg
//
