LOCUS       CR931632               22182 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 519/43 (serotype 1).
ACCESSION   CR931632
VERSION     CR931632.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 22182)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 22182)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..22182
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="519/43"
                     /db_xref="taxon:1313"
     gene            <1..163
                     /gene="dexB"
                     /locus_tag="SPC01_0001"
     CDS             <1..163
                     /gene="dexB"
                     /locus_tag="SPC01_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI32694.1"
                     /db_xref="GOA:Q4K2R1"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K2R1"
                     /translation="DRRFLVVANLSNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVP
                     WDAFCVELL"
     gene            321..494
                     /gene="aliB"
                     /locus_tag="SPC01_0002"
                     /pseudo
     CDS             321..494
                     /gene="aliB"
                     /locus_tag="SPC01_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
                     /db_xref="PSEUDO:CAI32695.1"
     gene            complement(order(490..630,2097..2279,2281..2826))
                     /gene="tnp"
                     /locus_tag="SPC01_0003"
                     /pseudo
     CDS             complement(join(490..630,2097..2279,2281..2826))
                     /gene="tnp"
                     /locus_tag="SPC01_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     gene            complement(order(665..1249,1306..1971))
                     /gene="tnp"
                     /locus_tag="SPC01_0004"
                     /pseudo
     CDS             complement(join(665..1249,1306..1971))
                     /gene="tnp"
                     /locus_tag="SPC01_0004"
                     /note="member of homology group 13"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1167 transposase"
     misc_feature    complement(join(1169..1249,1306..1515))
                     /gene="tnp"
                     /locus_tag="SPC01_0004"
                     /note="HMMPfam hit to PF01610, Transposase, score 6.6e-42"
                     /pseudo
     misc_feature    complement(2437..2808)
                     /gene="tnp"
                     /locus_tag="SPC01_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 4.1e-23"
                     /pseudo
     gene            3061..4506
                     /gene="wzg"
                     /locus_tag="SPC01_0005"
     CDS             3061..4506
                     /gene="wzg"
                     /locus_tag="SPC01_0005"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI32698.1"
                     /db_xref="GOA:Q4K384"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K384"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLICFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLLFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSKIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADS
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLTDGDRDRGRNQQKVIVAIIQKLTST
                     EVLKNYSSILQGLQDSLQTNIPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLTVVKAAIQDVMEGR"
     misc_feature    3061..3177
                     /gene="wzg"
                     /locus_tag="SPC01_0005"
                     /note="Signal peptide predicted for SPC0007 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    3265..3612
                     /gene="wzg"
                     /locus_tag="SPC01_0005"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 2.1e-62"
     misc_feature    3790..4233
                     /gene="wzg"
                     /locus_tag="SPC01_0005"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 1.3e-68"
     gene            4508..5239
                     /gene="wzh"
                     /locus_tag="SPC01_0006"
     CDS             4508..5239
                     /gene="wzh"
                     /locus_tag="SPC01_0006"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI32699.1"
                     /db_xref="GOA:Q4K383"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K383"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     misc_feature    4511..5119
                     /gene="wzh"
                     /locus_tag="SPC01_0006"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.3e-37"
     gene            5248..5940
                     /gene="wzd"
                     /locus_tag="SPC01_0007"
     CDS             5248..5940
                     /gene="wzd"
                     /locus_tag="SPC01_0007"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI32700.1"
                     /db_xref="GOA:Q4K382"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K382"
                     /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRNQGEKPGLTNQDLQAGAYLVKDYREIVLSQDVLEEVISDLKLD
                     LVPKGLANKIKVTVPVDTRIVSVSVSDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPAISPSSPNIKRNTLIGFLAGVIGTSVIVLLLELLDTRVKRPEDIENALQMT
                     LLGVVPNLGKLK"
     misc_feature    5266..5682
                     /gene="wzd"
                     /locus_tag="SPC01_0007"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.6e-50"
     misc_feature    5788..5865
                     /gene="wzd"
                     /locus_tag="SPC01_0007"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            5950..6615
                     /gene="wze"
                     /locus_tag="SPC01_0008"
     CDS             5950..6615
                     /gene="wze"
                     /locus_tag="SPC01_0008"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI32701.1"
                     /db_xref="GOA:P96475"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:P96475"
                     /translation="MPTLEIAQKKLEFIKKAEEYYNTLCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIAMSFARAGYKTLLFDGDIRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTPPIGIVI
                     DAAIITQKCDASILITATGEANKRDVQKAKQQLEQTGELFLGVVLNKLDISVDKYGVY
                     GRK"
     gene            6756..7892
                     /gene="wchB"
                     /locus_tag="SPC01_0009"
     CDS             6756..7892
                     /gene="wchB"
                     /locus_tag="SPC01_0009"
                     /note="member of homology group 206"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32702.1"
                     /db_xref="GOA:Q4K392"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K392"
                     /translation="MNLQKKKIMLITNHDDDIYCFRKEVIESLVEYGYEVLVSCPYGD
                     KIELMKSIQFEYEDITIDRRGINPLKDIRLFLSYIRLLRKYRPDVVLTYTVKPNVYAS
                     LAATILGIKYINNVTGLGSVLTMGSCVRSLVLLLFRISFRKSNCVFFQNEYNMKMLKT
                     LGLILGDSKLIPGSGVNIEKYPVQQYPNGGNGIQGETIVFNFIGRILKEKGIDTYLAA
                     AQIIKSRYPKTEFNIIGFIEPTESNYELKICDLEKKGIVYYLGQQKDVIPHITRSHAI
                     IHPSVYGEGMSNVLLENASSGRVLITTDNPGCKEIVKDRETGYIFQGGNVEELVSILE
                     VFLGLENEKRKEMGLQGRMYIEQYFSRQIIIDAYLDKIKGALDE"
     misc_feature    7305..7817
                     /gene="wchB"
                     /locus_tag="SPC01_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 2e-40"
     gene            7885..8436
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
     CDS             7885..8436
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
                     /note="member of homology group 207"
                     /codon_start=1
                     /transl_table=11
                     /product="galacturonic acid acetyl transferase"
                     /protein_id="CAI32703.1"
                     /db_xref="GOA:P96477"
                     /db_xref="HSSP:1MR9"
                     /db_xref="InterPro:IPR011004"
                     /db_xref="InterPro:IPR018357"
                     /db_xref="UniProtKB/TrEMBL:P96477"
                     /translation="MNRIIKNIVGLLRANICLILLKVCRNKDLTFHYFLKFGKNVTVE
                     QESNAKLILGKKIRVNAGGVLKVRKGAKLKISDDVFLSNNCMIACRKYIDIKSGVKCG
                     PGVLIYDHDYDVSVPGGLKAKKFKTAPVMIGENVWIGANSIVLKGVSIGENSVVAAGS
                     VVTKDIPADTIFIQKRLSREMKL"
     misc_feature    8098..8151
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 81"
     misc_feature    8269..8322
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 6.8"
     misc_feature    8296..8382
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
                     /note="PS00101 Hexapeptide-repeat containing-transferases
                     signature."
     misc_feature    8323..8376
                     /gene="wchC"
                     /locus_tag="SPC01_0010"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 1.7"
     gene            8433..9587
                     /gene="wchD"
                     /locus_tag="SPC01_0011"
     CDS             8433..9587
                     /gene="wchD"
                     /locus_tag="SPC01_0011"
                     /note="member of homology group 208"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32704.1"
                     /db_xref="GOA:P96478"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:P96478"
                     /translation="MKVFIATEFRCTIYKNEIYLKPKAYFIYERYAKAFGEIVLCSRY
                     EKVESYPEGYHKANFINKFIPIEGLHQVLFGQNKNKIIEGMIDSDLIVVRIPSIIGSK
                     TADYALKIGKPYLTEIMGDAWDSYWYHSLKGKLLAPYIYAKTKSIVKNANYCIYVTEK
                     YLQDRYPNIKSNIVASNVNITSVENRSLKSRLYKLKKFNPQKISIMTTASVNVRAKGH
                     RFVLEAMKRLEIQGILLDYYLAGDGDQSFLKKKAEELGVANRIHFLGELTTSQIYEYL
                     DKVDLYIQPSLQEGLPRAVIEAMSRACPCIGSNKAGIPELLGPHCLFTPSSSQAIAGS
                     IIDFISMDKEKMVIKQFEFSKKFLSSVLNKRRSDYFAQIRRELNNSDGLD"
     misc_feature    8997..9503
                     /gene="wchD"
                     /locus_tag="SPC01_0011"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 8.5e-22"
     gene            9704..11008
                     /gene="wzy"
                     /locus_tag="SPC01_0012"
     CDS             9704..11008
                     /gene="wzy"
                     /locus_tag="SPC01_0012"
                     /note="member of homology group 209"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI32705.1"
                     /db_xref="UniProtKB/TrEMBL:P96479"
                     /translation="MKFSLQSNDIKNKIILLVGVVFSGTLILCSENNDVTIPLFSMIF
                     LSFMAMIIVKFNIFHPYVWYSSFFTIYSISYPLLYRMEYINYGYTKDLIFMQWLALAT
                     LLLTLPSKAIVLSERKINLNNNNYLLFLNNMNTFITTVAIIYLLGSGFRNKGEIYSGA
                     NIVIMLVFSLVYFMILIHTYQLFIQLSTKKWRLLNCNTNTAIVICLFSIVTGERDYMF
                     TLFILDVIILFYFHKIKRFYLVMLVPLAALLIPLSAVFKYTLLSGQVSSINTNNIWFD
                     LLDGEFVSASRNLQILILHNMGNYFEGRSFFNDIVRIFYNTGYSNQTWFMDTFFPNVH
                     STKYGFTLVGEGYVNGGYFGIVMIFMLTGFLMRFLYINAQRNIYGMLIYLYMIPIFIY
                     STRADFANILSPLLKYAILGTLVIVFINRMVLISPLDEMGGE"
     misc_feature    9704..9799
                     /gene="wzy"
                     /locus_tag="SPC01_0012"
                     /note="Signal peptide predicted for SPC0014 by SignalP 2.0
                     HMM (Signal peptide probability 0.933) with cleavage site
                     probability 0.413 between residues 32 and 33"
     gene            11323..12363
                     /gene="wzx"
                     /locus_tag="SPC01_0013"
     CDS             11323..12363
                     /gene="wzx"
                     /locus_tag="SPC01_0013"
                     /note="member of homology group 210"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI32706.1"
                     /db_xref="GOA:Q4K388"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="InterPro:IPR004268"
                     /db_xref="UniProtKB/TrEMBL:Q4K388"
                     /translation="MNLVEIFYILGGVGLGQAYSTFKRNHSNEYQNKFVFLTFIQGLL
                     FGIIGLIIVLADVPIDYGGVIIVLSSLSIMRTNLTMIAVIENSIKRNKIVLGVSVVYS
                     VMLVLLLLFHLVSIEMVFLVYAINEFLRIILFLYYYNMFPVFEHISIKEFFTIYKFGF
                     LSMILTLLITFNYSIDIIMLKQMSSSYNVGIYSVAVTFSNMFLMVPDSFKEILFGDSA
                     KRTFEKNKAINAIKVSFLFMILLIIGFLSFGEFAITLLYGSSYIKAFPITLVIFLGSL
                     SMIFFKILQPIYISQGKQSVAIKILSVSALINISLNWYLIPNYQITGAAIASAISYTV
                     CGLFFIIDYLRN"
     gene            12431..13501
                     /gene="gla"
                     /locus_tag="SPC01_0014"
     CDS             12431..13501
                     /gene="gla"
                     /locus_tag="SPC01_0014"
                     /note="member of homology group 96"
                     /codon_start=1
                     /transl_table=11
                     /product="putative epimerase"
                     /protein_id="CAI32707.1"
                     /db_xref="GOA:P96481"
                     /db_xref="HSSP:1ORR"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR008089"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:P96481"
                     /translation="MRGKTILITGVAGFIGSNLVRKLLELEGTMTIIGLDNLNDYYDI
                     ALKDYRLLQLNKLIQDYPEKNWIFIKGDIADKMLINKIFKSYHPQIVVNLAAQAGVRY
                     SITNPDVYIESNIVGFHNVLEACRHSYEIYDGGVEHLVYASSSSVYGGNKKIPFATED
                     KVDNPISLYAATKKTNELQAYAYSKIYNIPSTGLRFFTVYGPAGRPDMAYFGFTDKLR
                     SGSDIEIYNHGNCKRDFTYIDDIVEGIVRVMQSAPKKLVGSDNLPLAPYKVYNIGNSK
                     PENLLDFVDVLQQELIKAGVLPENYDFDSHKKLVPMQPGDVPVTYADTSDLERDFGFK
                     PKTSLREGLRKFAEWYKDYYNV"
     misc_feature    12443..13486
                     /gene="gla"
                     /locus_tag="SPC01_0014"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 3.1e-05"
     misc_feature    12446..13249
                     /gene="gla"
                     /locus_tag="SPC01_0014"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 5.3e-58"
     misc_feature    12446..13255
                     /gene="gla"
                     /locus_tag="SPC01_0014"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 3.7e-06"
     misc_feature    12449..13327
                     /gene="gla"
                     /locus_tag="SPC01_0014"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 3.6e-09"
     gene            13530..14762
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
     CDS             13530..14762
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="member of homology group 20"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase Ugd"
                     /protein_id="CAI32708.1"
                     /db_xref="GOA:Q4K386"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR014028"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="UniProtKB/TrEMBL:Q4K386"
                     /translation="MKIAVAGTGYVGLSIAILLAQHHQVVAVDIIPEKVELINKKKSP
                     IQDDYIEKYLAEKELNLVATLNAEEAYENADFIVIAAPTNYDPKKNFFDTSSVEAVIE
                     AVMKYNPDAIIIIKSTVPVGYTKSVRRKFLTDNIMFSPEFLRESKALYDNLYPSRIII
                     GTDKDDKDLVKSAEIFVKMLQEGAVKENIETLYMDFTEAEAVKLFANTYLALRVSYFN
                     ELDTYSEMKGLDTQAIIDGVCLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYSDVPQ
                     EMITAIVQSNRTRKDYIADRILDLAGSYVGNDFYKPDKEKEIVVGIYRLTMKSNSDNF
                     RQSSIQGIMKRLKAKGVTIIIYEPTLESGTTFYGSQVVNDFEIFKKSSQVIVANRFDE
                     TLEDVRGKVYTRDIFKRD"
     misc_feature    13530..13610
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="Signal peptide predicted for SPC0017 by SignalP 2.0
                     HMM (Signal peptide probability 0.752) with cleavage site
                     probability 0.397 between residues 27 and 28"
     misc_feature    13530..13946
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="HMMPfam hit to PF00056, lactate/malate
                     dehydrogenase, NAD bind, score 0.0013"
     misc_feature    13530..14042
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="HMMPfam hit to PF01210, NAD-dependent
                     glycerol-3-phosphate deh, score 0.00016"
     misc_feature    13530..14063
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="HMMPfam hit to PF03721, UDP-glucose/GDP-mannose
                     dehydrogenase, score 9.3e-50"
     misc_feature    14115..14396
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="HMMPfam hit to PF00984, UDP-glucose/GDP-mannose
                     dehydrogenase, score 1.3e-36"
     misc_feature    14490..14741
                     /gene="ugd"
                     /locus_tag="SPC01_0015"
                     /note="HMMPfam hit to PF03720, UDP-glucose/GDP-mannose
                     dehydrogenase, score 9e-05"
     gene            complement(order(15448..15825,15829..16032,16086..16754))
                     /gene="tnp"
                     /locus_tag="SPC01_0016"
                     /pseudo
     CDS             complement(join(15448..15825,15829..16032,16086..16754))
                     /gene="tnp"
                     /locus_tag="SPC01_0016"
                     /note="member of homology group 13"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1167 transposase"
                     /db_xref="PSEUDO:CAI32709.1"
     misc_feature    complement(join(15952..16032,16086..16298))
                     /gene="tnp"
                     /locus_tag="SPC01_0016"
                     /note="HMMPfam hit to PF01610, Transposase, score 7.2e-43"
                     /pseudo
     gene            16968..17825
                     /gene="rmlA"
                     /locus_tag="SPC01_0017"
     CDS             16968..17825
                     /gene="rmlA"
                     /locus_tag="SPC01_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI32710.1"
                     /db_xref="GOA:O08434"
                     /db_xref="HSSP:1FXO"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:O08434"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLHRFQELLQDGSEFGIKLSYAEQPSTDGLAIGEEFISDDSVALIL
                     GDNIYHGPGLSTMLQKAAKKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEKPEYP
                     RSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRGFAWL
                     NTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKNEYGQ
                     YLLRLIGEA"
     misc_feature    16971..17675
                     /gene="rmlA"
                     /locus_tag="SPC01_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 6.2e-111"
     gene            17826..18422
                     /gene="rmlC"
                     /locus_tag="SPC01_0018"
     CDS             17826..18422
                     /gene="rmlC"
                     /locus_tag="SPC01_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI32711.1"
                     /db_xref="GOA:O08435"
                     /db_xref="HSSP:1NZC"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:O08435"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     VLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENLEEADVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    17862..18392
                     /gene="rmlC"
                     /locus_tag="SPC01_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 1.7e-15"
     gene            18432..19481
                     /gene="rmlB"
                     /locus_tag="SPC01_0019"
     CDS             18432..19481
                     /gene="rmlB"
                     /locus_tag="SPC01_0019"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI32712.1"
                     /db_xref="GOA:O08436"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O08436"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLVAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGIYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQATD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    18447..19403
                     /gene="rmlB"
                     /locus_tag="SPC01_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 8.7e-05"
     misc_feature    18450..19190
                     /gene="rmlB"
                     /locus_tag="SPC01_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 7.5e-76"
     misc_feature    18453..19265
                     /gene="rmlB"
                     /locus_tag="SPC01_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 5.1e-05"
     gene            19547..20398
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /pseudo
     CDS             19547..20398
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
     misc_feature    19547..20392
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.2e-142"
                     /pseudo
     misc_feature    19550..20176
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-16"
                     /pseudo
     misc_feature    19550..20188
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 6e-05"
                     /pseudo
     misc_feature    19553..20278
                     /gene="rmlD"
                     /locus_tag="SPC01_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 6.3e-08"
                     /pseudo
     gene            order(20522..21427,21438..21624)
                     /gene="tnp"
                     /locus_tag="SPC01_0021"
                     /pseudo
     CDS             join(20522..21427,21438..21479,21517..21624)
                     /gene="tnp"
                     /locus_tag="SPC01_0021"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    20522..20923
                     /gene="tnp"
                     /locus_tag="SPC01_0021"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 0.0093"
                     /pseudo
     gene            21826..>22182
                     /gene="aliA"
                     /locus_tag="SPC01_0022"
     CDS             21826..>22182
                     /gene="aliA"
                     /locus_tag="SPC01_0022"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI32715.1"
                     /db_xref="GOA:Q4K378"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4K378"
                     /translation="MKSSKLLALAGVTLLAATTLAAWSGSGSSTKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDA
                     KWYTSEGEEYAAVKAQD"
     misc_feature    21826..21897
                     /gene="aliA"
                     /locus_tag="SPC01_0022"
                     /note="Signal peptide predicted for SPC0028 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.207 between residues 24 and 25"
     misc_feature    22069..22137
                     /gene="aliA"
                     /locus_tag="SPC01_0022"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     7202 a   3322 c   4521 g   7137 t
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact tgacagtaga
       61 aggaaaagtc aaatctgtct tgattgaaaa caccctagct caagaagtct ttgaaaaaca
      121 aatcttagtt ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa
      181 atttaaaatt gaaatcatat aaaaacaagg gaggactgta taaaagcaga aatcctttgt
      241 tttttataac caaggtttat aaactttcat tctcgaaatt caattaactt tacaaattcc
      301 cactattaag gagaaagaag atgaacataa agaagcgtgt ccttagtgca ggcctgactt
      361 ttgcatctgt tttgctttta gctgcttgcg gccaatcagg ttcagataca aaaacttact
      421 catcaacctt tagtggaaat ccaactacat ttaactatct attagactat tacactgata
      481 atatagtcaa ttgaaacaag aacaagacaa aagagcctca taaaaggtat tgcaacttgg
      541 taataccttt ttgaggtgct ttttgatatg agcccatgtt ttctcaatag gattgtactc
      601 aggtgagtag ggaggaagag gtaaaagctt aggctctttg tcaactgtag tgggttgaag
      661 tcagctaagc tcgagaaagg acaaatttcg tcctttcttt tttgatgttc agagcgatga
      721 aaatccgttt tttgaagttt tcaaagtttc gaaaaccaaa ggcattgcgc ttgataagtt
      781 tgatgagatt attggtcgct tccagtttgg cgttagaata gtgtagttga agggcgttga
      841 caatcttttc tttatctttg aggaaggttt taaagacagt ctgaaaaata ggatgaacct
      901 gcttaagatt gtcctcaata agtccgaaaa atttctctgg ttccttattc tggaaatgaa
      961 aaagcaagag ctgatagagt tgatagtggt gtttcaagtc ttccgaataa ctcaaaagct
     1021 tgtttaaaat ctctttattg gttcaatgca tacgaaaagt aggacgataa aaatgtttat
     1081 cactcagttt acgactatcc tgttgaatga gtttccagta gcgcttgata gccttgtatt
     1141 catgggattt tcgatgaaac tgatttatga tttgaacacg cacacgactc atagcacggc
     1201 taagatgttg tacaatgtga aagcgatcca acacgatttt agcattcggg agtgaaacag
     1261 tctgggagac tgtttcagcc tgagcctaga aatttgaaag cgaaactgtt tagccaagtc
     1321 atagtaaggg ctaaacatat ccatagtaat gattttgacg cgacatcgga caactctatc
     1381 gtagcgaaga aagtgatttc gaatgatagc ttgtgttcta ccctcaagaa cagtgatgat
     1441 attgagattg ttaaaatctt gcgcaatgaa gctcatcttt ccctttgtaa aagcatactc
     1501 atcccaagac ataatctcag gaagacaaga aaaatcatgt ttaaagtgaa aatcattgag
     1561 cttacgaata acagttgaag ttgagatgga aagctgatgg gcaatatcag tcatagaaat
     1621 cttttcaatt aacttttgag caatcttttg gttgatgata cgagggattt ggtgattctt
     1681 cttgacgata gaagtttcag cgaccatcat ttttgaacag tgatagcact tgaatcgacg
     1741 ctttctaagg agaattctag taggcatacc agtcgtttca agataaggga tcttagacgg
     1801 tttttgaaag tcatatttct tcattagact tccacaatca gggcaagatg gagcctcata
     1861 atccagctta gcgataattt ctttgtgggt atccatattg atgatatcta gaatcttgat
     1921 gtttgggtct ttgatatcga gtagttttgt gataaaatgt aattgtccca tatgaatctt
     1981 tctaatgagt tgtttggtcg cttttcatta taggtcatat gggacttttt ttctacaata
     2041 aaataggctc cataatatct ataagggatt tacccactac aaatattata gagccaaagt
     2101 ttatacccaa actcctcgca taaaagttct aacttaccca ttctatggaa tcttgcatta
     2161 tccataataa taaccgatgg tgtggttaat gttggtaaga gaaacttctg aaaccaagct
     2221 tcaaaaaagt cgctcgtcat cgtctcttcg taagtcattg gagcgattaa ctcaccattc
     2281 atttgttaga cctgcaacca aagaaattct ctgatatctt cttccagata ctttgcctct
     2341 tcttaactga ccttttaatg agcgaccata ttctcgataa aaataagtat cgaatcctgt
     2401 ttcgtcaatc taaacaggtg ctaggtgctt taaactatta aaattcttaa gaaataaggc
     2461 tactttttct gggtcttgtt catagtaggt gtggttcttt tttcgagtgt agcccatagc
     2521 tttgagcgca tagtggatgg tagttggatg acagccaaag tcagaagcta tttcagtcaa
     2581 ataagcgtct ggattgtcag taagatagtt tttaagtcta tctctatcaa cttttcttgg
     2641 ttttgttcct tttacttggt ggtttagctc tcctgttttc tcttttagct ttaaccagcc
     2701 ataaatggta ttacgtgaga tttggaaaac gtgtgatgct tctgttatac tacctgttcg
     2761 ctcacaataa gagagaactt ttttacgaaa atctattgaa tatgccataa gaagattata
     2821 ccacattgtg tactatatta tattgaaact agaatagtac acatctgatt ctaaaacatt
     2881 gttagaaatc gatttgactg tcctgattga tttgtcctat tcttatttca ttttactata
     2941 tttttggttc gcgggaagtc tactaagata cttaaagatg cagatagtga aaataaaggt
     3001 gtagacatta ccgtaaaaaa gtgatataat tgtatgatgt tcaaggtata ggtgttaatc
     3061 atgagtagac gttttaaaaa atcacgttca cagaaagtga agcgaagtgt taatatcgtt
     3121 ttgctgacta tttatttatt gttaatttgt tttttattgt tcttaatctt taagtacaat
     3181 atccttgctt ttagatatct taacctagtg gtaactgcgt tagtcctact agttgccttg
     3241 gtagggctac tcttgattat ctataaaaaa gctgaaaagt ttactatttt tctgttgctg
     3301 ttctctatcc ttgtcagctc agtgtcgctc tttgcagtac agcagtttgt tggactgacc
     3361 aatcgtttaa atgcgacttc taattactca gaatattcaa tcagtgtcgc tgttttagca
     3421 gatagtaaga tcgaaaatgt tacgcaactg acgagtgtga cagcaccgac tgggactgat
     3481 aatgaaaata ttcaaaaact actagctgat atcaagtcaa gtcagaatac cgatttgacg
     3541 gtcaaccaga gttcgtctta cttggcagct tacaagagtt tgattgcagg ggagactaag
     3601 gccattgtcc taaatagtgt ctttgaaaat atcatcgagt cagagtatcc agactacgca
     3661 tcgaagataa aaaagattta taccaaggga ttcactaaaa aagtagaggc tcctaagacg
     3721 tctaagaatc agtctttcaa tatctatgtt agtggaattg acacctatgg tcctattagt
     3781 tcggtgtcgc gatcagatgt caatatccta atgactgtca atcgagatac caagaaaatc
     3841 ctcttgacca caacgccacg tgatgcctat gtaccaatcg cagatagtgg aaataatcaa
     3901 aaagataaat taacccatgc gggcatttat ggagttgatt cgtccattca caccttagaa
     3961 aatctctatg gagtggatat caattactat gtgcgattga acttcacttc tttcttgaaa
     4021 atgattgact tattgggagg ggtagatgtt cataatgatc aagagttttc agctctacat
     4081 gggaagttcc atttcccagt agggaatgtc catctagact ctgagcaagc tttaggtttt
     4141 gtacgtgaac gctactcact aaccgatgga gaccgtgacc gtggtcgcaa ccaacaaaag
     4201 gtcattgtag caattattca gaagttaact tctacagagg ttttgaaaaa ctatagtagt
     4261 attcttcaag gattgcagga ttctcttcaa acaaatatac cgattgagac tatgatagat
     4321 ttagtgaata ctcagttgga aagtggaggg aattataaag taaattctca agatttaaaa
     4381 gggacaggtc ggatggatct tccttcttat gcaatgccag acagtaacct ctatgtgatg
     4441 gaaatagatg atagtagttt aactgtagtt aaagcagcta tacaggatgt gatggagggt
     4501 agataaaatg atagacatcc attcgcacat cgtctttgat gtagatgatg gtcccaagtc
     4561 aagagaggaa agcaaggctc tcttggcaga atcctacagg cagggggtga gaaccattgt
     4621 ctctacctct caccgtcgca agggcatgtt tgaaactccg gaagagaaga tagcagaaaa
     4681 ctttcttcag gttcgggaaa ttgcaaaaga agtagcagat gatttagtca ttgcttatgg
     4741 cgcagagata tactatactc tggatgctct agaaaagcta gaaaaaaaag aaattcctac
     4801 ccttaatgat agtcgttatg ccttgattga gtttagcatg catacttcct atcgtcagat
     4861 tcatacggga ttgagcaata ttttgatgtt gggaatcacg ccagtaattg ctcatattga
     4921 acgttatgat gctttagaga ataacgaaaa acgtgttcgt gaactgattg atatggggtg
     4981 ctatactcag ataaatagtt atcatgtttc aaaacctaag ttctttggtg aaaaatataa
     5041 attcatgaaa aagagagctc ggtatttttt ggaacgtgat ttagttcatg tagttgcaag
     5101 tgacatgcac aatttagaca gtagacctcc atatatgcaa caggcatatg atatcattgc
     5161 taagaaatat ggagcgaaaa aagcgaaaga actttttgta gataatccca gaaaaattat
     5221 aatggatcaa ttaatttagg agaaaatatg aaggaacaaa acactttgga aatcgatgta
     5281 ttgcaactat tcagagcttt atggaaaaga aagttggtca ttttattagt ggcaattata
     5341 acttcttcag ttgcttttgc ctacagtact tttgttatca aacctgagtt tactagtacg
     5401 actcggattt atgtagttaa ccgtaatcag ggagagaagc ctggtttaac caatcaagac
     5461 ttgcaggcag gagcatactt ggttaaagac tatcgtgaaa ttgtcctatc gcaggatgtt
     5521 ttggaggaag ttatttctga tttgaaacta gatttggtgc caaaaggttt ggctaataaa
     5581 attaaagtaa cagtaccagt tgatacccgt attgtctctg tttcagttag tgatcgagtt
     5641 cctgaagagg caagccgtat cgctaactct ttaagagaag tagctgctca aaaaattatc
     5701 agtattactc gtgtttctga tgtgacaaca ctggaggagg caagaccggc gatatcaccg
     5761 tcttcgccaa atattaaacg caatacacta attggttttt tggcaggggt gattggaact
     5821 agtgttatag ttcttcttct tgaacttttg gacactcgtg tgaaacgtcc ggaagatatc
     5881 gaaaatgcac tgcagatgac acttttggga gttgtaccaa acttgggtaa gttgaaatag
     5941 gagagagaga tgccgacatt agaaatagca caaaaaaaac tggagttcat taagaaggca
     6001 gaagaatatt acaatacctt gtgtacaaat atacagttga gcggagataa actaaaagta
     6061 atttccgtta cttctgttaa tccgggggaa ggaaaaacaa ctacttccgt aaatatagca
     6121 atgtcatttg cgcgtgcagg ctataaaact cttttgttcg atggcgatat tcgaaattca
     6181 gttatgtcag gattttttaa atctcgtgaa aaaattacag ggctaacaga atttttatct
     6241 gggacagctg atttatctca cggtttatgt gatacaaata ttgaaaattt atttgtagtt
     6301 caatcgggat ctgtatcacc aaaccctaca gccttgttac aaagtaaaaa ttttaatgat
     6361 atgattgaaa cattgcgtaa atattttgat tatatcattg ttgatacacc acctattgga
     6421 attgttattg atgcggcaat tatcactcaa aagtgtgatg cgtccatctt gataacagca
     6481 acaggtgagg cgaataaacg tgatgtccaa aaagcgaaac aacaattaga acaaacaggg
     6541 gaactgttcc tgggagttgt tttaaataaa ttggatatct cggttgataa gtatggagtt
     6601 tacggtcgta aatagtttgt aagttctata tgtgtataga attttaaagt gtcacaattt
     6661 ggaaacaatt acttatagaa aattactatt tttaaaatga tagttgtaaa ggataatgga
     6721 gtagcggtta attatatttt aggaagatta ttttgatgaa tttacaaaag aaaaaaatta
     6781 tgttaataac taatcatgac gatgatatct attgttttcg aaaagaagtt atagagtcac
     6841 tagttgagta tgggtatgaa gtgctagtgt catgtcctta tggagataag atagagttga
     6901 tgaagtctat tcaatttgag tatgaagata ttactattga tagaagagga ataaaccctt
     6961 taaaagatat tcgtctattt cttagttata taagattatt gagaaaatat agaccggatg
     7021 tagtcttgac atataccgtg aaaccaaatg tatatgctag cctagctgca acaattttag
     7081 gaataaaata tataaataac gtaacaggtt taggtagtgt cttaacaatg ggttcttgtg
     7141 taagaagcct ggtgttatta ctgtttagaa tttcttttag gaaatcaaat tgtgtttttt
     7201 ttcaaaatga atataatatg aaaatgttaa aaactcttgg cttgattttg ggtgactcta
     7261 agctgatacc tgggtcagga gtgaacattg aaaagtatcc tgtgcaacag tatccaaatg
     7321 gtggaaatgg aattcaagga gaaacaatcg tttttaattt tattggtagg atattaaaag
     7381 aaaaaggtat agatacttat ctggctgctg cccaaattat taagagtcga tatcccaaaa
     7441 cagagtttaa tattattggc tttatagaac cgacagagag taattatgaa cttaaaattt
     7501 gtgacttaga aaaaaaagga atcgtttatt atttgggaca acaaaaagat gtgatacctc
     7561 atattacccg ttcccatgca attatccatc ccagtgtgta tggtgaagga atgagcaatg
     7621 tattactaga aaacgctagt tcaggacgtg ttttaattac gacagataat ccaggttgca
     7681 aagaaattgt taaagataga gagacaggct atatatttca agggggaaat gttgaggaac
     7741 tagtctctat attggaagtt tttttaggtc tagaaaatga aaaacgaaaa gagatgggac
     7801 ttcaagggag aatgtatata gagcaatatt tttctcgtca aattattata gatgcttatt
     7861 tagataaaat aaaaggagct ttagatgaat aggattataa aaaatattgt tggtttactt
     7921 cgtgcaaata tttgcttgat attattaaaa gtgtgtcgaa acaaggatct tacttttcat
     7981 tattttttaa aatttggaaa gaatgtaact gtcgaacagg aatctaatgc taaattaatc
     8041 ttaggaaaaa agattagagt aaacgccggg ggagtattga aagttagaaa aggagcaaaa
     8101 ctcaagattt ctgatgatgt atttttgagt aataattgta tgatagcttg tcgtaaatac
     8161 atagatatta aatctggagt aaaatgtggt cctggagtac ttatatatga tcatgactat
     8221 gatgttagtg ttccaggtgg attgaaagca aaaaaattta agacggcccc agttatgatt
     8281 ggagaaaatg tttggattgg agctaacagc attgtcttga agggagtgag tattggtgag
     8341 aatagtgtgg ttgcagcagg aagtgttgta acaaaggata ttccagctga tactatattt
     8401 attcagaaac gtttatcaag ggagatgaaa ttatgaaagt atttatagcg actgaattta
     8461 gatgtacaat ctataaaaat gaaatatatt taaaaccgaa agcttatttt atttatgagc
     8521 gctatgctaa agcatttgga gagattgtac tatgtagtcg ttatgagaag gtggaatcat
     8581 accctgaagg atatcataaa gcgaacttta ttaataaatt tatccctata gaaggtctac
     8641 atcaggttct atttggtcaa aataaaaata agattattga aggaatgatt gatagcgact
     8701 taatagttgt tcgtattccg tctataattg gatcaaaaac tgcagactac gcattgaaga
     8761 taggtaagcc gtatctgaca gaaataatgg gggatgcttg ggattcttac tggtatcata
     8821 gtttaaaggg aaaattatta gctccatata tatacgccaa aactaaatca attgtaaaaa
     8881 acgctaatta ttgcatatac gtgacagaaa aatatttaca agatagatat cctaatatta
     8941 aatctaatat cgttgcttca aatgttaata ttacctctgt agagaataga tctttgaaga
     9001 gccgtcttta taagttgaaa aaatttaatc ctcaaaaaat ttcaataatg acaacagcat
     9061 ctgtgaatgt acgagccaag ggccatagat ttgtattgga agcaatgaag agattagaaa
     9121 tacaaggtat tttgttggat tattatttag caggtgatgg tgatcaaagt ttcttaaaaa
     9181 agaaagcaga ggaattggga gtagcgaata gaatccattt tttaggggaa ttgactacat
     9241 cacaaattta tgagtatttg gataaagttg atttatatat acaaccaagt ttacaagaag
     9301 ggttacctcg tgcggtaatt gaagctatga gccgtgcttg cccttgtata gggtctaata
     9361 aagcaggaat tccagagttg ctggggccac attgtctatt tactccatcc tcttcacaag
     9421 cgattgcggg atctattata gattttatta gtatggataa ggaaaagatg gtgataaaac
     9481 agtttgaatt ctcaaaaaaa tttctttcga gtgtattaaa taaacgcaga agtgactatt
     9541 ttgctcaaat tagaagagaa ttaaataatt ctgatggttt agattaaaat gcgatggaaa
     9601 atccgtttcg atatattaaa tatgctataa aaactgacta catagccaat caaatttttg
     9661 aatacgcatt acgtttaaat tattagttaa aggaaaaaag taaatgaagt ttagtctaca
     9721 atcaaatgat ataaaaaata aaataatact tctagtaggt gtagtttttt cagggacttt
     9781 aattttatgc agtgaaaata atgatgttac aattccatta ttttcaatga tttttttaag
     9841 ttttatggca atgataattg tgaaatttaa tatttttcat ccctatgtgt ggtatagtag
     9901 cttctttact atttattcta tttcttaccc gctactctat agaatggagt atataaacta
     9961 tggttataca aaagatttga ttttcatgca atggctggct ttggcaactt tgttgttaac
    10021 tctaccttct aaagccattg tgttaagcga aaggaaaata aacctaaata acaataacta
    10081 tttattattt ctcaataata tgaatacgtt tatcacaaca gtagcaatta tatatctatt
    10141 aggaagtggt tttagaaata aaggggaaat atattcaggt gccaatattg tgataatgtt
    10201 agtattttct ttggtttatt ttatgattct cattcataca tatcagctat ttatacagtt
    10261 gagtactaaa aaatggagac tactaaattg taatactaac acagcgatag ttatctgtct
    10321 cttctctatc gttacagggg aaagagatta tatgtttact ttattcatcc ttgatgtgat
    10381 tatattattt tactttcaca aaataaaacg tttttatctt gtaatgttag ttccgcttgc
    10441 ggcactactg attccgttat ctgcagtttt taaatatact ttattaagtg ggcaagtttc
    10501 atctataaat acaaataata tttggtttga tttgctagat ggtgagtttg tatcagctag
    10561 tcgtaattta cagattctga tattacataa tatgggcaat tatttcgaag gtcgttcttt
    10621 ttttaatgac atagtaagaa ttttttataa tacggggtat tctaatcaaa cttggtttat
    10681 ggacaccttt tttccaaacg tacattcaac caaatatggt tttactcttg tgggagaggg
    10741 atatgtgaat ggaggatact ttggaattgt aatgattttt atgctaacag gctttttgat
    10801 gagatttctt tatataaacg ctcaaagaaa tatatacggg atgctgatat atctgtatat
    10861 gatacctatt tttatttatt ctactcgtgc tgattttgct aacatattat ctccattact
    10921 taaatatgct atattgggaa cattggttat tgtttttatc aatagaatgg tgttgatatc
    10981 accattggat gaaatgggtg gtgagtagtt tatttaaaaa ggtggggtat actttttgat
    11041 actatagtgg tttgaagttg gagtagtaca atgcagcttc taaagaattt ttataaatta
    11101 ctttaaattc cctaatcgtt ttgttcatat tctatttcaa tatactataa ttttaaattt
    11161 actgttataa aatttaacat acggagaaaa taagtgagac tatctaagaa atattggttt
    11221 gctttaacga gtaaattttt gttaatctta ttaacacttt tatcctcaat tataattaat
    11281 aggggattag gtgttgaaaa aaaaggagat tatgcctatg taatgaactt agtagaaatt
    11341 ttttatattt taggtggagt tggtttaggt caggcttact cgacctttaa aaggaatcat
    11401 tctaatgagt atcagaataa atttgttttt ttaactttta ttcaaggatt attgtttgga
    11461 ataataggtt taataatagt tttagctgat gttccgatag attatggtgg ggtaataata
    11521 gttttgtcca gtctatctat tatgagaaca aatcttacta tgattgcagt aatagaaaat
    11581 agtataaaga ggaataagat tgtattagga gtaagcgtag tatattccgt tatgctagta
    11641 ttgttgttac tatttcattt agtttctata gagatggtat ttttggtata tgctattaat
    11701 gaatttttac gtatcatttt atttttatac tattacaata tgttcccagt ttttgaacat
    11761 attagtatta aagaattttt cactatatat aagtttggat ttctttctat gattcttact
    11821 ctattaatta catttaatta tagtattgat atcataatgt tgaagcaaat gtctagtagt
    11881 tataatgtag gtatatacag tgtcgcagtt acgttttcta atatgttttt gatggttcca
    11941 gactcattta aagagatttt atttggtgat tcggctaaaa gaacttttga gaaaaataaa
    12001 gcaataaatg caataaaagt atcatttcta tttatgattt tattaattat tggatttctt
    12061 tcttttggag aatttgcgat tacgctcctt tatggttcca gttatataaa ggcatttcct
    12121 ataacattag tcattttttt aggaagctta tcgatgattt tctttaaaat tttacaacca
    12181 atttatatat ctcagggtaa acagagtgta gctataaaaa ttttatctgt gtcggctttg
    12241 ataaatataa gtttaaactg gtacttaatt cctaactacc aaattacagg agctgcgata
    12301 gcatcagcaa tctcttatac tgtatgtggt ttgtttttta ttatagatta tcttagaaat
    12361 tgattataat agttgttaaa gaatgtgtat tagtggatga aaatataaaa ataacaagag
    12421 gtattatgat atgagaggaa aaacaattct aattacagga gtagctggtt ttattggatc
    12481 aaatctggtt aggaaattat tggaattaga aggaacgatg acaatcattg gtttggacaa
    12541 tttgaatgat tactatgata ttgcacttaa agattatcga ttgcttcaac ttaataagct
    12601 aattcaggat tatccagaaa aaaactggat atttatcaag ggtgatattg cagataaaat
    12661 gcttattaat aagattttta agagttatca tcctcagatt gttgttaatc tagctgccca
    12721 ggcaggagta cgctactcca ttacaaatcc agatgtatat atagaaagta atatcgttgg
    12781 ctttcataat gtgttggaag cttgtcgtca ttcgtatgag atatatgatg gtggtgtgga
    12841 acacttagtt tatgcatcgt cctcatcggt atatggtgga aataaaaaaa tcccgtttgc
    12901 aacagaagat aaggtagaca atcctatttc actatatgct gcgactaaaa aaacaaatga
    12961 acttcaagcg tatgcttatt caaagattta caatattcct tcgacaggct tacgcttttt
    13021 tacagtttat ggtcctgctg ggcgcccaga tatggcctat tttggattta cagataaatt
    13081 gcgaagtggt tccgatattg agatttataa tcatggtaat tgtaaacgag attttactta
    13141 tatagatgat atcgttgagg ggatagtaag ggtcatgcaa tcagctccga agaaactagt
    13201 gggatctgat aatttaccgt tagccccata taaagtgtac aatattggga atagtaaacc
    13261 cgaaaatttg ttagattttg tggatgttct tcaacaggag ctaatcaagg caggagtttt
    13321 gccggaaaat tatgattttg atagtcataa aaaattagtt cctatgcaac caggcgatgt
    13381 tcctgttact tatgcagata caagtgattt agagagagat tttggtttta aaccaaaaac
    13441 ttctttacga gaaggtttga gaaagtttgc agagtggtat aaagactact ataatgtata
    13501 acgagagtgt tttgagaaag gaaaaaatta tgaaaatagc agtagcaggt acaggatatg
    13561 ttggattatc tattgcaatc ttactggctc aacatcatca agttgttgcc gtagatatca
    13621 ttcctgagaa agttgagtta atcaataaaa agaagtcccc tatccaagac gattatatag
    13681 aaaaatatct cgcggaaaaa gaattgaatc tcgtagctac attgaatgca gaggaagcat
    13741 atgagaatgc ggattttata gttattgcgg ctccaactaa ttatgatccg aaaaaaaatt
    13801 ttttcgatac atcttcagtc gaggctgtca ttgaagcagt tatgaaatat aatcctgatg
    13861 caattataat aattaaaagt actgttcctg ttggatatac aaagtcagta cggaggaaat
    13921 ttcttacaga caatattatg tttagtcctg agtttttacg ggagtcaaaa gcgttatatg
    13981 ataacctata tccgagtcga attattatag gtacagataa agatgataaa gatttggtaa
    14041 agtctgctga aatttttgta aaaatgcttc aggaaggtgc agtgaaagaa aatattgaaa
    14101 cattgtatat ggattttaca gaagctgaag cagtaaaact ttttgctaat acctatcttg
    14161 ccctccgggt ttcctatttt aacgagttag atacttattc tgagatgaaa ggactagata
    14221 ctcaagcgat tattgatgga gtttgtttag atccgagaat aggttctcac tacaataatc
    14281 cttcttttgg ttatgggggt tactgtcttc ctaaagatac caagcaactt cttgcaaatt
    14341 attctgacgt tccacaagaa atgataacag ctatagtaca aagtaatcgg acaagaaaag
    14401 attatattgc agatcgtatt ttagatcttg ctggatctta tgtaggcaat gatttctata
    14461 aaccagataa agaaaaagag attgttgtag gaatttatcg tttaacaatg aaaagtaatt
    14521 cagataattt tagacaatct tctattcaag gtattatgaa gcgtttgaaa gcaaaaggtg
    14581 ttactattat tatttacgaa ccaactcttg aaagtggtac tactttctat ggtagtcaag
    14641 tagttaatga ttttgaaata tttaagaaat ctagtcaagt gattgttgca aatcgttttg
    14701 atgagacttt agaagatgtg aggggtaaag tttatactag ggatattttt aagagagatt
    14761 aaatcaattt gtatatttct agtccctaat aatctatatc atttgaatga tagaatagtt
    14821 aaaaactagc tggaggatag cgacaactca tctaaaacaa taaagatatt tctatattct
    14881 cgctcgcact tagtgaagta aatatacttc ttttgtcagt agagattgac ttaataggat
    14941 atagttgcat atattccttc gaagtgaggt gctgataatg gcagtaattt ttaaaaatgt
    15001 gcttattgaa gagaagactg aagaagaaaa acaacatatt ctatctattc taaatggtga
    15061 gtatgactta tctgatgatg taagttgtag attacgacga ctgaatgagg aaagtaaacg
    15121 cttggaagtg tttgttaagg agacgaactc acttgtctag ttcgtattct gttaatgaat
    15181 tgaaatcaat aagtatctca ttgtcatttt ttaactatga ggaagttaga gatttctaat
    15241 agctctccag ttactatgta atttagcatt gaaaaactaa gaaatggtga aattatgcct
    15301 tttacacagt tatttaaaac atccttagga attgattttt aattgtatgc aaacaaagta
    15361 gaattcgctt atttcatttc atgctaaatg taatatgaag taagtgaatt tttaggctct
    15421 ttgtcaactg tagtgggttg aagtcagcta agctcgagaa aggacaaatt tcgtcctttc
    15481 ttttttgatg ttcagagcga tgaaaatccg ttttttgaag ttttcaaagt ttcgaaaacc
    15541 aaaggcattg cgcttgataa gtttgatgag attattggtc gcttccagtt tggcgttaga
    15601 atagtgtagt tgaagggcgt tgacaatctt ttctttatct ttgaggaagg ttttaaagac
    15661 agtctgaaaa ataggatgaa cctgcttaag attgtcctca ataagtccga aaaatttctc
    15721 tggttcctta ttctggaaat gaaaaagcaa gagctgatag agttgatagt ggtgtttcaa
    15781 gtcttccgaa taactcaaaa gcttgtttaa aatctcttta ttggttcaat gcatacgaaa
    15841 agtaggacga taaaaatgtt tatcactcag tttacgacta tcctgttgaa tgagtttcca
    15901 gtagcgcttg atagccttgt attcatggga ttttcgatga aactgattta tgatttgaac
    15961 acgcacacga ctcatagcac ggctaagatg ttgtacaatg tgaaagcgat ccaacacgat
    16021 tttagcattc gggagtgaaa cagtctggga gactgtttca gcctgagcct agaaatttga
    16081 aagcgaagct gtttagccaa gtcatagtaa gggctaaaca tatccatagt aatgattttg
    16141 acgcgacatc ggacaactct atcgtagcga agaaagtgat ttcgaatgat agcttgtgtt
    16201 ctaccctcaa gaacagtgat gatattgaga ttgttaaaat cttgcgcaat gaagctcatc
    16261 tttccctttg taaaagcata ctcatcccaa gacataatct caggaagaca agaaaaatca
    16321 tgtttaaagt gaaaatcatt gagcttacga atagcagttg aagttgagat ggaaagctgc
    16381 tgggcaatat cagtcataga aatcttttca attaactttt gagcaatctt ttggttgatg
    16441 atacgaggga tttggtgatt cttcttgacg atagaagttt cagcgaccat catttttgaa
    16501 cagtgatagc acttgaatcg acgctttcta aggagaattc tagtaggcat accagtcgtt
    16561 tcaagataag gaattttaga aggtttttga aagtcatatt tcttcaattg acttccgcac
    16621 tcagggcaag atggagcctc ataatccagc ttagcgataa tttctttgtg ggtatccata
    16681 ttgatgatat ctagaatctt gatgtttggg tctttgatat cgagtagttt tgtgataaaa
    16741 tgtaattgtc ccatatgaat ctttctaatg agttgtttgg tcgcttttca ttatagatct
    16801 tatgggactt tttttctaca ataaaatagg ctccataata tctatagtgg atttacccac
    16861 tacaaatatt atagagccat ataaaacatg ggatgattgt tttcttttta gagcagtaca
    16921 caattaatag taattgactc taaaataaca aagaaaggta ccctactatg aaaggtatta
    16981 ttctagcagg tggttcgggg acacgtttat atcctttgac tcgcgctgcg tcaaaacaac
    17041 ttatgccggt ttatgataaa ccgatgattt actacccact ttcaacattg atgttggctg
    17101 ggattaggga tattttgatt atttccactc cacaggattt acatcgattt caagagcttc
    17161 ttcaagacgg atctgagttt gggatcaaac tttcttatgc agagcaacca agtacagatg
    17221 gtttggcaat tggggaagag tttatttctg acgatagcgt tgccttgatt ttaggcgaca
    17281 atatctacca tggtcctggt ctgagcacaa tgcttcaaaa agcagccaag aaagagaaag
    17341 gtgcgactgt ttttggctac caagtgaagg atccagagcg ttttggtgtg gttgagtttg
    17401 atacagacat gaatgctatt tccatagaag aaaaaccgga gtatcctcgc tccaactatg
    17461 cagtgacagg actgtatttc tatgataacg atgttgtcga aattgccaag agtattaaac
    17521 caagccctcg tggtgaactg gaaattacag atgtaaacaa ggcttaccta gatcgtggtg
    17581 atttgtctgt tgagcttatg ggacgtggct ttgcttggct gaatactgga actcatgaaa
    17641 gtttactaga ggcttcacag tacatcgaaa cagtgcaacg gatgcaaaat gttcaggtag
    17701 caaacttaga agaaattgct taccgtatgg gctatatcag tcgagaagat gtattggcct
    17761 tagcccaacc acttaagaaa aatgaatacg gacagtatct gctccgtttg attggagaag
    17821 catagatgac agataatttt ttcggtaaga cgcttgcggc acgcaaggtt gaagctattc
    17881 caggcatgtt ggagtttgat atccccgttc atggagataa tcgtggctgg tttaaagaaa
    17941 atttccaaaa ggaaaaagtg cttccacttg gatttccaga gtctttcttt gcagaaggaa
    18001 aattgcaaaa caatgtatcc ttctcacgta aaaatgtcct tcgaggcctc cacgcagagc
    18061 cttgggataa gtacatctct gtagcagatg gagggaaagt tctgggttct tgggttgatc
    18121 tacgcgaggg tgaaaccttt gggaatacct atcagacagt aattgatgca agcaagggaa
    18181 tctttgttcc tcgaggcgta gctaatggct tccaagtttt atcagataca gtgtcatata
    18241 gctatctggt caatgattac tgggctcttg aactcaaacc caagtatgcc tttgtgaact
    18301 acgctgatcc aagccttggt attgaatggg aaaatctgga agaagcagac gtatctgaag
    18361 cagacaaaca tcatccccta cttaaggacg tgaagccttt gaaaaaagaa gatttggaat
    18421 aaggaaagaa tatgactgaa tacaaaaata ttatcgtgac aggtggagct ggctttatcg
    18481 gttctaactt tgtccattat gtttacgaga actttccaga tgttcacgtg acagtcctag
    18541 ataagttgac ttatgctgga aaccgcgcga atattgagga aattttaggc aatcgtgttg
    18601 agttagttgt tggtgacatt gctgatgcgg agttggtaga caagttggtt gctcaagcag
    18661 atgctatcgt tcattatgca gcggaaagcc acaatgataa ttcgctcaat gatccatcgc
    18721 catttattca tactaacttc attggaatct atactctttt agaagctgct cgtaagtatg
    18781 atattcgctt ccaccatgta tcgacagatg aagtttatgg ggatctccct ttacgagaag
    18841 atttgccagg tcatggtgaa ggaccaggtg agaaatttac tgctgaaaca aaatacaacc
    18901 caagctctcc gtactcatca accaaggccg catcagactt gattgtcaaa gcctgggtgc
    18961 gttcttttgg agtcaaggca acgatttcca actgttcaaa taactacggt ccttatcaac
    19021 atatcgaaaa attcatccca cgtcagatta ctaacatcct aagtggaatt aagccaaaac
    19081 tttacggtga aggtaagaac gttcgtgact ggattcatac caatgaccat tcttcaggag
    19141 tttggacaat cttgacaaaa gggcaaatcg gtgaaaccta cttgattggg gctgatggtg
    19201 agaagaacaa taaggaagtt ttggaactta tccttaagga aatgggacaa gctacggatg
    19261 cctatgatca tgtgactgac cgtgcaggac atgaccttcg ctatgcgatt gatgccagca
    19321 agctccgtga tgagttgggg tggaaacctg aatttaccaa ctttgaagct gggctcaagg
    19381 caacaatcaa gtggtataca gataaccaag aatggtggaa agcagaaaaa gaagctgttg
    19441 aagccaatta tgctaagact caggagatta ttacagtata aaaagcagga aatcgctgct
    19501 ttttattgct atattgggaa gagttacata ttagaaaggt ctagagatga ttttaattac
    19561 aggggcaaat ggccaattag gaacggaact tcgctattta ttggatgaac gtaatgaaga
    19621 atacgtggca gtagatgtgg ctgagatgga cattaccaat gaagaaatgg ttgagaaagt
    19681 ttttgaagag gtgaaaccga ctttagtcta ccattgtgca gcctacaccg ctgttgatgc
    19741 agcagaggat gaaggaaaag agttggactt cgccatcaat gtgatgggga caaaaaatgt
    19801 cgcaaaagca tctgaaaagc atggtgcaac tctagtttat atttctacgg actaggtctt
    19861 tgacggtaag aaaccagttg gacaagagtg ggaagttgat gaccgaccag atccacagac
    19921 agaatatgga cgcactaagc gtatggggga agagttagtt gagaagcatg tgtctaattt
    19981 ctatattatc cgtactgcct gggtatttgg aaattatggc aaaaacttcg tttttaccat
    20041 gcaaaatctt gcgaaaactc ataagacttt aacagttgta aatgaccagt acggtcgtcc
    20101 gacttggact cgtaccttgg ctgaattcat gatctaccta gctgaaaatc gtaaggaatt
    20161 tggttattat catttgtcaa atgatgcgac agaagacaca acatggtatg attttgcagt
    20221 tgaaattttg aaagatacag atgtcgaagt caagccagta gattccagtc aatttccagc
    20281 caaagctcaa cgtccgctaa actcaacgat gagcctggcc aaagccaaag ctactggatt
    20341 tgttattcca acttggcaag atgcattgca agaattttac aaacaagaag tgagataagt
    20401 agtagaatga ttttctagtc taataaaaga ggcagataat gaactccaaa ggagcttaag
    20461 atgtacaatt atcttgttgt tggtgctggt ctctttggtg catagctttg gctcagtttc
    20521 tattatcgct cacaccatcc atcagaagtt taatctgaag gtacccaatt atcgccaaga
    20581 agaagattgg gctaggatgg gtttaccaat cacacgtaag gaaatctcta attggcatat
    20641 caaggcaagt caatactatt tagagtccct ttataagctt ttacgagaaa agttgttaga
    20701 acaacctctt cttcatgcgg atgaaacctc ttatcgggtt ctagagagtg atagccatct
    20761 gacctactat tggacttttt tgtctgggaa agctgagaat caagcaatca cgctgtacca
    20821 ccatgatcag cgtcggagtg gtttagtagt acaagaattc ctaggagatt attctggcta
    20881 tgtgcattgt gatatgttgc ggcagtaact taggacttta gtcctctagt tctgcctatg
    20941 cgatagcagt ccaaggttta ggagcaaggc gacgctaagc ttggtaaact gcgaaccgct
    21001 agaagcttat cgtcaactgg aagaagctga acttgttgga tgttgggcac atgtgagaag
    21061 gaagtttttt gaagcgcccc ccaagcaaac ggataaatca tccttaggag ctaaaggttt
    21121 agcttattgt gatcagttat tttccctgga aagagactgg gaggctttgc cagctgatga
    21181 acgactacag aaacgtcaag aacatctcca gcccctaatg gaagacttct ttgcttggtg
    21241 ccggcgtcag tcagttttag caggttcaaa actaggaagg gcaattgaat acagcctcaa
    21301 gtatgaagaa acctttaaga ctattttgaa agacggacat ctggtccttt ccaataatct
    21361 agctgaatgc gccattaaat cattggttat gggacggagt aaaagagtcc agtggactct
    21421 tttagcctaa gctcagttta aaaaagcgag ggtggttatt ttctcaaagt tttgaaggag
    21481 ctaaagcaag agctattata attaaatagc gagaaatatc tatcctatct tctagaatgt
    21541 cttccaaacg aggaaactct cgtaaacaaa gagattttag aggcctattt accgtggact
    21601 aaagttgtac aagaaaagtg caaataagaa atctccagat taggaactat ccgtgagttc
    21661 tctagtctgg agatttttca atagacttcg ttattgggcg gttacgatat tcatattttt
    21721 tgcaaagatg ttatttgaaa aataattttc aaaaattctg aaaattctgt tgacaacttt
    21781 ctgaaaagag tctataatgg agagaaagtt ttaaaggaga aaaggatgaa aagttcaaaa
    21841 ctacttgccc ttgcgggcgt gacattattg gcggcgacta ctttagctgc atggtctgga
    21901 tcaggttcaa gcactaaagg tgagaagaca ttctcataca tttatgagac agaccctgat
    21961 aacctcaact atttgacaac tgctaaggct gcgacagcaa atattaccag taacgtggtt
    22021 gatggtttgc tagaaaatga tcgctacggg aactttgtgc cgtctatggc tgaggattgg
    22081 tctgtatcca aggatggatt gacttacact tatactatcc gtaaggatgc aaaatggtat
    22141 acttctgaag gtgaagaata cgcggcagtc aaagctcaag ac
//
