LOCUS       CR931658               27104 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 559/66 (serotype 12a).
ACCESSION   CR931658
VERSION     CR931658.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 27104)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 27104)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..27104
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="559/66"
                     /db_xref="taxon:1313"
     gene            <1..163
                     /gene="dexB"
                     /locus_tag="SPC12A_0001"
     CDS             <1..163
                     /gene="dexB"
                     /locus_tag="SPC12A_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI33214.1"
                     /db_xref="GOA:Q4K2R1"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K2R1"
                     /translation="DRRFLVVANLSNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVP
                     WDAFCVELL"
     gene            322..490
                     /gene="aliB"
                     /locus_tag="SPC12A_0002"
                     /pseudo
     CDS             322..490
                     /gene="aliB"
                     /locus_tag="SPC12A_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(491..1024,1026..1232,2935..3060))
                     /gene="tnp"
                     /locus_tag="SPC12A_0003"
                     /pseudo
     CDS             complement(join(491..1024,1026..1232,2935..3060))
                     /gene="tnp"
                     /locus_tag="SPC12A_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(order(962..1024,1026..1232,2935..3042))
                     /gene="tnp"
                     /locus_tag="SPC12A_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 3e-20"
                     /pseudo
     gene            complement(1423..2769)
                     /gene="tnp"
                     /locus_tag="SPC12A_0004"
     CDS             complement(1423..2769)
                     /gene="tnp"
                     /locus_tag="SPC12A_0004"
                     /note="member of homology group 225"
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1380-Spn1 transposase"
                     /protein_id="CAI33217.1"
                     /db_xref="GOA:Q97CV5"
                     /db_xref="InterPro:IPR002559"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="UniProtKB/TrEMBL:Q97CV5"
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKE
                     RISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQL
                     ASQPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEG
                     VAYNAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFR
                     MDSGFATPKLYDLIEKTGQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSET
                     LYQAGSWSHKRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIK
                     EMKEGFFGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLH
                     VVGKCVRTGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPRRKASLMMH"
     misc_feature    complement(1672..2340)
                     /gene="tnp"
                     /locus_tag="SPC12A_0004"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 6.9e-24"
     gene            3265..4719
                     /gene="wzg"
                     /locus_tag="SPC12A_0005"
     CDS             3265..4719
                     /gene="wzg"
                     /locus_tag="SPC12A_0005"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33218.1"
                     /db_xref="GOA:Q4JYN0"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN0"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     FAFRYLNLVVTVLVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIIDSLQNSIQTNMPLETMINLVNAQLESGGSYKVNSQDLKGTGRMDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    3265..3402
                     /gene="wzg"
                     /locus_tag="SPC12A_0005"
                     /note="Signal peptide predicted for SPC0545 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 46 and 47"
     misc_feature    3478..3825
                     /gene="wzg"
                     /locus_tag="SPC12A_0005"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 2.3e-64"
     misc_feature    4003..4446
                     /gene="wzg"
                     /locus_tag="SPC12A_0005"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            4721..5452
                     /gene="wzh"
                     /locus_tag="SPC12A_0006"
     CDS             4721..5452
                     /gene="wzh"
                     /locus_tag="SPC12A_0006"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33219.1"
                     /db_xref="GOA:Q4JYM9"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JYM9"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLVEAYRQGVRTIVSTSHRR
                     KGMFETPEEKIEENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKSKLFGERYKFMKKRAQYFLEQDLVHAIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    4724..5332
                     /gene="wzh"
                     /locus_tag="SPC12A_0006"
                     /note="HMMPfam hit to PF02811, PHP domain, score 7.8e-36"
     gene            5458..6153
                     /gene="wzd"
                     /locus_tag="SPC12A_0007"
     CDS             5458..6153
                     /gene="wzd"
                     /locus_tag="SPC12A_0007"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33220.1"
                     /db_xref="GOA:Q4JYM8"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4JYM8"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILLVALVTGAGAFAYSAFI
                     VKPEYTSTTRIYVVNRDQGDKSGLTNQDLQAGTYLVKDYREIILSQNVLEKVATNLKL
                     DIPAKTLARKVQVTVPVDTRIVSISVKDKQPEEASRIANSLREVAAEKIIAVTRVSDV
                     TTLEEARPATTPSSPNVRLNSLFGFFGGAVVTVIAVLLIELFDIRVKRPEDVEDVLQI
                     PLLGVVPDLNKMK"
     misc_feature    5458..5574
                     /gene="wzd"
                     /locus_tag="SPC12A_0007"
                     /note="Signal peptide predicted for SPC0547 by SignalP 2.0
                     HMM (Signal peptide probability 0.729) with cleavage site
                     probability 0.460 between residues 39 and 40"
     misc_feature    5479..5895
                     /gene="wzd"
                     /locus_tag="SPC12A_0007"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.5e-54"
     misc_feature    6001..6078
                     /gene="wzd"
                     /locus_tag="SPC12A_0007"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            6163..6837
                     /gene="wze"
                     /locus_tag="SPC12A_0008"
     CDS             6163..6837
                     /gene="wze"
                     /locus_tag="SPC12A_0008"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33221.1"
                     /db_xref="GOA:Q4K1Y2"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y2"
                     /translation="MPTLEISQAKLDFVKKAEENYNALCTNLQLSGDDLKVFSITSVK
                     QGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITQKCDASILVTKAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGKK"
     gene            order(7111..7536,7548..7925)
                     /gene="tnp"
                     /locus_tag="SPC12A_0009"
                     /pseudo
     CDS             join(7111..7536,7548..7925)
                     /gene="tnp"
                     /locus_tag="SPC12A_0009"
                     /note="member of homology group 148"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1515 transposase"
     misc_feature    order(7444..7536,7548..7916)
                     /gene="tnp"
                     /locus_tag="SPC12A_0009"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 1.1e-10"
                     /pseudo
     gene            8057..8656
                     /gene="wciI"
                     /locus_tag="SPC12A_0010"
     CDS             8057..8656
                     /gene="wciI"
                     /locus_tag="SPC12A_0010"
                     /note="member of homology group 29"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33223.1"
                     /db_xref="GOA:Q4JYM6"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="UniProtKB/TrEMBL:Q4JYM6"
                     /translation="MYREIKRLGDILLSFIGIIVLFPVFIIIAIAIKLDSKGPVIFKQ
                     KRFGLHKKSFYVLKFRTMKVESPKYVATRDLDKPEQWITKVGACLRKTSLDELPQLWN
                     ILVGDMSVVGPRPVAINELDLIKEREQYGANDILPGLTGWAQINGRDNLSTEMKAEID
                     GYYVKHMSLRMDLRCILRTIPYVLKRKGIVEGSGKKELE"
     misc_feature    8057..8149
                     /gene="wciI"
                     /locus_tag="SPC12A_0010"
                     /note="Signal peptide predicted for SPC0551 by SignalP 2.0
                     HMM (Signal peptide probability 0.855) with cleavage site
                     probability 0.449 between residues 31 and 32"
     misc_feature    8072..8626
                     /gene="wciI"
                     /locus_tag="SPC12A_0010"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 1.4e-36"
     gene            8622..9887
                     /gene="wciJ"
                     /locus_tag="SPC12A_0011"
     CDS             8622..9887
                     /gene="wciJ"
                     /locus_tag="SPC12A_0011"
                     /note="member of homology group 35"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33224.1"
                     /db_xref="GOA:Q4JYM5"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4JYM5"
                     /translation="MWRVVVRKSWSDAMKILFVCQHYKPEPFRLSDICEDLVQRGHEV
                     AVLTGIPNYPEGEIYADYRKRKKRRETINGVAIFRSYTIARRQNTLYRILNYFSFALS
                     STIGVIFGRYKAKDGSDFDCVFVNQLSPVMMAWAGIAYKNKYNKPMFLYCMDVWPDSL
                     IVGGVKENGLIYKIFEFVSKKVYQASDYIFVTSLSFKDYFVKKFNIPLHKITYLPQYA
                     EDLFVPNELKTNKNTIDLTFAGNIGKAQNLETILKAASAIEQIPDLAKRVHFHFVGDG
                     TELLNMQKLACELELENTSFYGRRPLEEMPDFYTKSDAMLVSLIGDSIISRTLPGKVQ
                     SYMAAGKPIIGAISGDTQRVVKEAKCGFISPEGNVDQLVRNIRKFCLLSVEEREKLGR
                     QARCCYEEQFSKEWFMTYLENHLKEGFLS"
     misc_feature    9279..9812
                     /gene="wciJ"
                     /locus_tag="SPC12A_0011"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.7e-14"
     gene            9836..11053
                     /gene="wcxB"
                     /locus_tag="SPC12A_0012"
     CDS             9836..11053
                     /gene="wcxB"
                     /locus_tag="SPC12A_0012"
                     /note="member of homology group 55"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33225.1"
                     /db_xref="GOA:Q4K1Z8"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Z8"
                     /translation="MVYDILRKSFKRGVSIMKVLMINSVCGIRSTGRICTDLATALTE
                     EGYEVKIAYGREYVPKQFQQYAVKIGTKSDIRFHAIRSRLFDESGFGSRQATVNFIKW
                     IKEFDPDVIHLHNLHGYYINIELLFDYLRICGKKIIWTLHDCWAFTGHSAHFDCLECE
                     SKGVCDHPSQKNDYPKSFVNFSKRNYQRKKKCFTHIPNLTIVTPSQWLANLVGQSFLK
                     EYPVKVIHNGIDTTVFQPRLIAAQKLKKRYHLEGKQVLLGVAAIWTDKKGFSDMLVLA
                     SHLADNQRIVLIGLKDRQLKKLPKGIIGLTETNSPEELAAWYTLADVFLNPTYQDSYP
                     TTNLEAISCGTPVISYPTGGSVESAKLYGLVCQDRNVASILSSLEKVSQLSKTEKLDF
                     SIASFIKQMKYLY"
     misc_feature    10556..11038
                     /gene="wcxB"
                     /locus_tag="SPC12A_0012"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 3.6e-12"
     gene            11091..12302
                     /gene="wzy"
                     /locus_tag="SPC12A_0013"
     CDS             11091..12302
                     /gene="wzy"
                     /locus_tag="SPC12A_0013"
                     /note="member of homology group 71"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33226.1"
                     /db_xref="InterPro:IPR007016"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Z7"
                     /translation="MMKRIYYHLLAILAWTLPNSYAFIDSLKVFFPNISLQIAGSLLA
                     VISIGIFITRIYYTGYEVFISLLVCIFILIFYSTRFFYSINVELYQSFFNSFLIRPVP
                     GILVAMLLAKNNHIKGFIKWSEPMMLFYTLTSFLAALSPRNSIIIYQSLSYYAMTAYM
                     INVFNIIYKEKILEEQLTYFRFSAWNFIRYFLLLIQAFNALSGGGRGAFILLIIFTGI
                     LLIRIAMNFKFLFSFIGGLSAIALVVFCIKDLDFTWLLNMDGGERLLNFFGRPERIST
                     DNRLLIYDTVWSAIQEKPFLGWGVGSTFLKFNGYSHNIVLDLLHDMGSFGLLIILSAF
                     FASSVILYKLRKIDWKVNLFILMFLEVYVHMSFSGSYLADGRLWFLVIFTYCYYRWKV
                     QEKDEVSNFII"
     misc_feature    11907..12074
                     /gene="wzy"
                     /locus_tag="SPC12A_0013"
                     /note="HMMPfam hit to PF04932, O-Antigen Polymerase, score
                     1.1e-08"
     gene            12277..13353
                     /gene="wcxD"
                     /locus_tag="SPC12A_0014"
     CDS             12277..13353
                     /gene="wcxD"
                     /locus_tag="SPC12A_0014"
                     /note="member of homology group 72"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33227.1"
                     /db_xref="GOA:Q4K1Z6"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Z6"
                     /translation="MKLAILLSDISKIGGVQRVTTALVNELCQNIDVTIISIFSENEL
                     PAFGLSDRVQVSYLLKEHVNLKKNFFKVSGALRKVLKKQQFDVVLSSGTGLVSFLWFA
                     SLGIPTRLLAWEHQCFYFGRSFGLEWLGRKLACRFAESIVVLTKKDEGFYKENRPKAH
                     IEQIYNILDMDSQTAKCQLSSKKIISVGSLGRQKGFDLALEVASQIQLSYPDWQWDIY
                     GDGPDREKLEEKVREYQLEGFINLKGLVQNVRELYPDYSIYALTSRYEGLSMALLEAK
                     NCQMPAISFDCNCGPSDIISDGRNGFLIDCFDVNIYAKTLSKLMTSLELREQVAKSSV
                     IPAEELSTTYILDKWNNLLKIERR"
     misc_feature    12778..13284
                     /gene="wcxD"
                     /locus_tag="SPC12A_0014"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.6e-32"
     gene            13355..14533
                     /gene="wcxE"
                     /locus_tag="SPC12A_0015"
     CDS             13355..14533
                     /gene="wcxE"
                     /locus_tag="SPC12A_0015"
                     /note="member of homology group 73"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33228.1"
                     /db_xref="GOA:Q4K1X6"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X6"
                     /translation="MKIVHVEDFFHPDAGYQINVLPKYLAKFGHEQVIITSEMDKIPD
                     NLTQFFGRENIEERDRSYEEKHHVKIIRLPLHGFVSGRAIFSGKLISAIKGLSPEVLY
                     IHGNDTLTGIRLLLARKKLNCRIVTDSHMLEMASRNPFNNYFRRFYKTLITPILIKEQ
                     IPIIRTQDDNYVEKHLGIPLSQAPWISYGSDTAFFHADSQIKEDFRSQYQIASDALIC
                     VYAGKLDEHKGGMFLAESLSKKLNTEQPIVFIIVGNTNGEYGEAVEKSFSQSENQILR
                     FPTQKYQKLAQFFQVADFALFPKQCSLSFYDAQACGLPVLLEDNNINLDRTSHYNGWT
                     FKANSKLSLRDSLKMIASLDKEKRQEYSQNALHYILEHYNYEDKAREYEKILIGERTK
                     "
     misc_feature    13958..14458
                     /gene="wcxE"
                     /locus_tag="SPC12A_0015"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.00013"
     gene            14566..15762
                     /gene="wcxF"
                     /locus_tag="SPC12A_0016"
     CDS             14566..15762
                     /gene="wcxF"
                     /locus_tag="SPC12A_0016"
                     /note="member of homology group 74"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33229.1"
                     /db_xref="GOA:Q4K1Z4"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Z4"
                     /translation="MDLMKICIVSVGVGGLPIPAVKGGAVENLIDNYLSYNEKYNHDE
                     ITVVSCDHKEAREASKKYKYAQFVYIDIHSLKYKINKTIRYAINKYSPFFVGNAYISQ
                     LPDLSGFDTVLIENRPEYGYYIRKKFKGNLVLHLHNDLLMDNEYSVDYSVYDKIITIS
                     DYIRDRSEVVTSGVPIQTVYNGIDTELFLQNFSEIDLSDLKNQLEILSDDFVIVFFGR
                     INKNKGIKELLEAFLLIPKNLNIKLLAVGSSIFGQTELDTFTTELRQLAKQASDKVVF
                     TGYVNYKDIPKYHHIADCIVVPSIWEEPAGLTVCEALISGKYVITTDAGGIPEIVAGS
                     EALVVANDECIVEHLKTALLSVYQKGKCSSVITSNRDRGAYFSIEKYGRDLRKELTQN
                     ERIINI"
     misc_feature    14566..14640
                     /gene="wcxF"
                     /locus_tag="SPC12A_0016"
                     /note="Signal peptide predicted for SPC0557 by SignalP 2.0
                     HMM (Signal peptide probability 0.653) with cleavage site
                     probability 0.406 between residues 25 and 26"
     misc_feature    15154..15681
                     /gene="wcxF"
                     /locus_tag="SPC12A_0016"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 2.2e-28"
     gene            15759..17303
                     /gene="wzx"
                     /locus_tag="SPC12A_0017"
     CDS             15759..17303
                     /gene="wzx"
                     /locus_tag="SPC12A_0017"
                     /note="member of homology group 56"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33230.1"
                     /db_xref="GOA:Q4JYL9"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4JYL9"
                     /translation="MSRVKNSFFNILAGIVGTIISSVLAFIVRTVFIRVLGETYLGFN
                     GLYTNILTVLSLTELGIGSSIAYLMYKPLAEKDGDKLAQVVQFYKKIYRVIGIIILIL
                     GLCLVPFLPVIVNLKNAEDLNYTALYLLYLADTVSTYLFFAYKRGVLAADQKIYVANI
                     FDIIITTILSIFQIITLMIFKDFYLYIILKIAKNLTLNLVISLKVDKMYPSIHKFKGI
                     APLPKMERRLVWKNVYATSVRQIFNELMNSTDSIVISIVLGIVMVGKYSNYAYILSIV
                     YIFFGGIFNPIQASIGNLSLSASIEKKNEIFNRLRFINFFFLSFCSSCLLVLVNPFIT
                     IWIGENYTLSFTGVIAIVGMLFVRQTGNCTTIFRLGEGYFRDYHFSPLIAGILNLVVS
                     VILVNYIGIAGVFVGTMLGFGFQFILVDTIVTYKKVLSRPLSEFYLRWLQTILLTVGL
                     CIASYYLSRLVRVNSIYDLILLFVVVIGFNFFALCFIYWRNDDFQYFIQLVKNFMKNL
                     EEKNHD"
     misc_feature    15759..15833
                     /gene="wzx"
                     /locus_tag="SPC12A_0017"
                     /note="Signal peptide predicted for SPC0558 by SignalP 2.0
                     HMM (Signal peptide probability 0.819) with cleavage site
                     probability 0.398 between residues 25 and 26"
     gene            17296..18519
                     /gene="mnaB"
                     /locus_tag="SPC12A_0018"
     CDS             17296..18519
                     /gene="mnaB"
                     /locus_tag="SPC12A_0018"
                     /note="member of homology group 75"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmannosamine dehydrogenase MnaB"
                     /protein_id="CAI33231.1"
                     /db_xref="GOA:Q4K1X3"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR014028"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X3"
                     /translation="MINVIGLGYIGLPTILMLATNGVKVVGTDYNQDLVRTLNEGQTT
                     FKEDGLDELFHKAVESGVDFTTEYQQTDTYIISVPTPYDSFSKKIDPSYVIEATKTVL
                     DNCNKGAVIIIESTVSPGTVDKFIRPVVEEKGFVIGSDIHLVHAPERIIPGNMVYELV
                     NNNRTIGADDLEIGYKVKELYASFCKGDIVVTDIRTAEMTKVVENTFRAVNIAFANEL
                     AQICSYDNMNVYEIIRICNMHPRVNILQPGPGVGGHCISVDPWFLVGDYPELTNVIEH
                     SMRTNAAMPEFVLNRIYTIMNEHHLTDISRVGLYGLTYKENVDDMRESPTLQLLESMS
                     RHLATPAIKVYDPFIEKDVVANQSHDLDEFLSNVDIVVLLVGHDEILQNMDKLKDKIV
                     LDTRYICHLDGTYRL"
     misc_feature    17299..17853
                     /gene="mnaB"
                     /locus_tag="SPC12A_0018"
                     /note="HMMPfam hit to PF03721, UDP-glucose/GDP-mannose
                     dehydrogenase, score 1.4e-45"
     misc_feature    17875..18135
                     /gene="mnaB"
                     /locus_tag="SPC12A_0018"
                     /note="HMMPfam hit to PF00984, UDP-glucose/GDP-mannose
                     dehydrogenase, score 4.5e-33"
     misc_feature    18217..18480
                     /gene="mnaB"
                     /locus_tag="SPC12A_0018"
                     /note="HMMPfam hit to PF03720, UDP-glucose/GDP-mannose
                     dehydrogenase, score 2.5e-15"
     gene            18542..19645
                     /gene="mnaA"
                     /locus_tag="SPC12A_0019"
     CDS             18542..19645
                     /gene="mnaA"
                     /locus_tag="SPC12A_0019"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33232.1"
                     /db_xref="GOA:Q4K1V3"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K1V3"
                     /translation="MTMKKIVVIFGTRPEAIKMCPLVKELRTRENLETLVCVTGQHRQ
                     MLDQVLDTFRITPDFDLSIMKDKQTLFDVTIGILEGMKTVLESVNPDLILVHGDTSTT
                     FASSLAAFYLQIPIGHVEAGLRTYDIYSPYPEEFNRQAVGALAQYHFTPTQLSKDNLL
                     REGKNSEAIFITGNTAIDALQTTIQEDYTHPELNWVGDSKLILITAHRRENIGDPMRH
                     MFRAIRRIIEEHSDIKALYPIHMNPLVRQIAEEELSGCERIKMIDPLEVLDFHNFLSR
                     SYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEGIKAGTLKLVGTDEDNIYRHFKELL
                     ENDLVYQAMSQASNPYGDGTACKKIADILEGEV"
     misc_feature    18611..19633
                     /gene="mnaA"
                     /locus_tag="SPC12A_0019"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 2.5e-174"
     gene            19649..20704
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
     CDS             19649..20704
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="member of homology group 36"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlA"
                     /protein_id="CAI33233.1"
                     /db_xref="GOA:Q4JYL6"
                     /db_xref="InterPro:IPR003869"
                     /db_xref="InterPro:IPR013692"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYL6"
                     /translation="MSQFTGKTLLITGGTGSFGNAVLNRFLQTDIGEIRIFSRDEKKQ
                     DDMRHEFQVKVPEVAGKIRFYLGDVRDLASVKNAMHGVDYVFHAAALKQVPSCEFFPV
                     EAVKTNILGTENVLTAAIEAGVKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAKSRTV
                     NPEHTKICVTRYGNVLCSRGSVVPLWIEQIKQGNALTITEPSMTRFVMTLEEAVDLVL
                     FAFEEGKSGDILVQKAPACTIEVLAKAVSEIFASEQDIKIIGIRHGEKRYETLLTNEE
                     CANAIDLGDFYRVPSDNRNLNYDKYFKDGSTNRNLLTEFNSNNTDLMDVEQVKRKLLE
                     LDEIQTAIRDMVADEEM"
     misc_feature    19670..20524
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.0018"
     misc_feature    19673..20344
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 8.3e-09"
     misc_feature    19673..20521
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 3.1e-162"
     misc_feature    19676..20311
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 8.4e-09"
     misc_feature    20522..20665
                     /gene="fnlA"
                     /locus_tag="SPC12A_0020"
                     /note="HMMPfam hit to PF08485, Polysaccharide biosynthesis
                     protein C, score 2e-23"
     gene            20804..22033
                     /gene="fnlB"
                     /locus_tag="SPC12A_0021"
     CDS             20804..22033
                     /gene="fnlB"
                     /locus_tag="SPC12A_0021"
                     /note="member of homology group 37"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlB"
                     /protein_id="CAI33234.1"
                     /db_xref="GOA:Q4K1Y9"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y9"
                     /translation="MIKNILITGAKGFVGKNLICTLEALKDGRDRTRPNLEIGEIFQY
                     DRDTDPILLDEYCKKADFVFHLAGVNRPQNPDEFMEGNYGFSSRLLEILEKYENTCPV
                     LLSSSTQASLEGRFSNSIYGQSKLAGEELFFEYGKKTGAPVLVYRFPNLYGKWCRPNY
                     NSAVATFCHNIAHDLPIQVNDPSVELELLYIDDLIQECLTALEGNPHRCNLDGLQILP
                     SPSGNYCYVPTTHRATLGEIVSLLETFKKQPNSLVMPEIPQGSFKKKLYSTYLSYLPV
                     DKFRFPLKMNIDERGSFTELLKTENTGQFSVNISKPGITKGQHWHHSKWEFFMVVSGR
                     ALIQERRIGLDENGQEYPILNFEVSGDKIEAIHMIPGYAHNIINLSDTENLITVMWAN
                     ESFDPRHPDTFFEQVEK"
     misc_feature    20816..21439
                     /gene="fnlB"
                     /locus_tag="SPC12A_0021"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 3.5e-09"
     gene            22034..23218
                     /gene="fnlC"
                     /locus_tag="SPC12A_0022"
     CDS             22034..23218
                     /gene="fnlC"
                     /locus_tag="SPC12A_0022"
                     /note="member of homology group 38"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-L-fucosamine FnlC"
                     /protein_id="CAI33235.1"
                     /db_xref="GOA:Q4K1W9"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K1W9"
                     /translation="MKIKTDYSDIHFKDNGKLKLLIIVGTRPEIIRLSSVITKCRKYF
                     DVILAHTGQNYDYNLNGIFFDNLGLDTPDVYMDAVGDDLGATVGNIINTSYKLMNQIK
                     PDALLILGDTNSCLSAIAAKRLHIPIFHMEAGNRCKDECLPEETNRRIVDIISDVNLA
                     YSEHARKYLHECGLPKERTYVTGSPMAEVLHKNLSAIESSDIHERLGLKKGGYILLSA
                     HREENIDTDKNFISLFTAINQLAEKYNMPILYSCHPRSKKRLQESGFKLDKRVIQHEP
                     LGFHDYNCLQMNAFVVVSDSGTLPEESSFFTSQGYPFPAVCIRTSTERPESLDKAGFI
                     LAGIDENSLLQAVETAVSLAEDEDFGLPVPDYVEENVSTKVVKIIQSYTGIVDKIVWR
                     KS"
     misc_feature    22145..23173
                     /gene="fnlC"
                     /locus_tag="SPC12A_0022"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 4.8e-105"
     gene            complement(23413..23502)
                     /gene="tnp"
                     /locus_tag="SPC12A_0023"
                     /pseudo
     CDS             complement(23413..23502)
                     /gene="tnp"
                     /locus_tag="SPC12A_0023"
                     /note="Lone member of homology group 0226"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1167 transposase (fragment)"
     gene            complement(23584..24639)
                     /gene="tnp"
                     /locus_tag="SPC12A_0024"
                     /pseudo
     CDS             complement(join(23584..23901,23903..24253,24253..24639))
                     /gene="tnp"
                     /locus_tag="SPC12A_0024"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     gene            24720..24908
                     /gene="tnp"
                     /locus_tag="SPC12A_0025"
                     /pseudo
     CDS             24720..24908
                     /gene="tnp"
                     /locus_tag="SPC12A_0025"
                     /note="member of homology group 0047 7"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            complement(25120..25693)
                     /gene="tnp"
                     /locus_tag="SPC12A_0026"
                     /pseudo
     CDS             complement(join(25120..25443,25424..25693))
                     /gene="tnp"
                     /locus_tag="SPC12A_0026"
                     /note="member of homology group 31"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1671 transposase"
     misc_feature    complement(order(25424..25428,25126..25443))
                     /gene="tnp"
                     /locus_tag="SPC12A_0026"
                     /note="HMMPfam hit to PF05717, IS66 Orf2 like protein,
                     score 1.7e-52"
                     /pseudo
     gene            order(25760..25966,25968..26078,26095..26484)
                     /gene="tnp"
                     /locus_tag="SPC12A_0027"
                     /pseudo
     CDS             join(25760..25966,25968..26078,26095..26484)
                     /gene="tnp"
                     /locus_tag="SPC12A_0027"
                     /note="member of homology group 19"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1381 transposase (orf2)"
     misc_feature    order(26007..26078,26095..26472)
                     /gene="tnp"
                     /locus_tag="SPC12A_0027"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 4.6e-14"
                     /pseudo
     gene            26745..>27104
                     /gene="aliA"
                     /locus_tag="SPC12A_0028"
     CDS             26745..>27104
                     /gene="aliA"
                     /locus_tag="SPC12A_0028"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33241.1"
                     /db_xref="GOA:Q4K2T2"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKD
                     AKWYTSEGEEYAAVKAQD"
     misc_feature    26745..26831
                     /gene="aliA"
                     /locus_tag="SPC12A_0028"
                     /note="Signal peptide predicted for SPC0574 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
     misc_feature    26991..27059
                     /gene="aliA"
                     /locus_tag="SPC12A_0028"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     8622 a   4354 c   5495 g   8633 t
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact tgacagtaga
       61 aggaaaagtc aaatctgtct tgattgaaaa caccctagct caagaagtct ttgaaaaaca
      121 aatcttagtt ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa
      181 atttaaaatt gaaatcgtat aaaaacaagg gaggactgta taaaagacag aaatcctttg
      241 ttttttataa ccaaggttta taaactttca ttatcgaaat tcaattaact ttacaaattc
      301 ccactattaa ggagaaagaa aatgaacata aagaagcgtg tccttagtgc aggtctgact
      361 tttgcatctg ctttgctttt agctgcttgc gaccaatcag gttcagatac aaaaacttac
      421 tcatcaacct ttagtggaaa tccaactaca tttaattacc tgttagacta ttacgctgat
      481 aatatagtca attgaaacaa gagcaggaca aaagagcctc gtaaaaggta ttgcaacttg
      541 gtaatacctt ttacgaggct ttttgatatg agcccatgtt ttctcaatag gattgtactc
      601 aggtgagtag ggaggaagaa ggtaaaagtt tatgcccaaa ctcttcgcat aaaagttcta
      661 gcttccccat tctatggaat cttgcattat ccataataat aaccgatggt gtggttaatg
      721 ttggtaagaa aaacttctga aaccaagctt caaaaaagtc gctcgtcatc atctcttcgt
      781 aagtcattgg agtgattaac tcaccatttg ttagacctgc aaccaaagaa atcctctgat
      841 atcttcttcc agatactttg cctcttatta actgaccttt taatgagcga ccatattctc
      901 gataaaaata agtatcgaat cctgtttcgt caatctaaac aggtgctagg tgctttaatc
      961 tattaaaatt cttaagaaac aaggctactt tttctgggtc ttgttcatag taggtgtggt
     1021 tctttttttc gagtgtagcc catagctttg agcgcatagt ggatggtagt tggatgacag
     1081 ccaaattcag aagctatttc agtcaaataa gcgtctggat tgtcagtaag atagttttta
     1141 agtctatctc tatcaacttt tcttggtttt attcctttta cttggtggtt tagctctcct
     1201 gttttctctt ttagctttaa ccagccataa acccaaatca ttcatacctc tctcaactag
     1261 atgtaactta ccaaacccct gacctcatga gccactttct tcctcctcat gaggtcagtt
     1321 ttactttctg ctgttccagt atcgtttttc ctcgctagat ttcctcaaaa gggcagactc
     1381 ctcccttggt gcgtcacacg attttttcat ctcgactgtt ctttaatgca tcattaacga
     1441 cgcttttctt ctaggtggtt cataaggaac aggaagattc aggttgactt ttctaatcct
     1501 agaataaagt gctgaaaaca attcggaata ggcatagaga ctagacaatt tgaggagctg
     1561 cttgcgtcct gttcgaacac attttcctac cacgtgaaga aaaagatggc ggaagcgttt
     1621 gattgttaaa gtttggaagt cacctccagc tagatgtttg agaaaaagat agagattgta
     1681 ggcgatacag ctcatcatca tacgaacttc gtttttgatt aaggttgaac tatccgtttt
     1741 atcgccaaaa aatccctcct tcatctcctt gatgaaattc tcggcttgac cacgtccacg
     1801 ataaagctga aactggtctt ggcttgttcc actcgtcata tttgtaacga gagaaataac
     1861 atcgtagaac aagtttcctt cttttcgttc agagaactgg cagacacgac gcttgtgcga
     1921 ccaagatcct gcttgataga gagtttctga gtaggcggag tggggcaaga tggttaagtc
     1981 ctcatcctgt gggcaaggga gggaaaggtc tccaagacgg ctcagaacag tatttttctt
     2041 gagttttatg aggtagtatt gccctgtttt ttcaattaaa tcgtataatt ttggggtcgc
     2101 aaagccacta tccattcgaa agagaagttg attaaaccgt tctaaaacag gtgtgataaa
     2161 gctgtctgcc tcttcagaac aataacgatt accaggacga agctgggcat tgaaacaata
     2221 acctgtcttc ccctcgaaag cataaagagg atgatagcca tgagcacgat agtgggcgtt
     2281 ataagcaaca ccttcttgct tgccataagt tgtgaaatgg gtagaatcga tatctacaat
     2341 gagttggttt agctggtgaa actgtaaaaa gaattcgacc aattcaaggt tgaggcatcg
     2401 caaactatgg actgtttcct cgtcagttct ggaaagaaaa cgggataagg ttggctgtga
     2461 agcaagctgc cctccttcca acaattttgg aaagtaggca tcagctgaca attctttaca
     2521 agcatagtcc gttccataac ctgttaacag ttgaaagagg aactggacaa ggatatctga
     2581 atccgaataa cgacagtagc ggcgttggtc attcgttact aaatacttag aaatccgctc
     2641 ttttagtttc aactgggaaa aaagttcctg aaaaaagata agaccaccat actgggttaa
     2701 atgacctcca tcgaaagata gttggtaaaa agacttgttt tggaagtgat gatttggtaa
     2761 actgttcatg tgagtttcct ttctttttgt gtttttttct acacttatac cataaagggg
     2821 aaactctttt ttgtctagta aaaaacaccc attgggtgaa aaaagaaacc atccaggatc
     2881 taagctaagg caaggattct ggatggtttt tagatttggg gtgaataatt ggggataaat
     2941 ggtattacgt gagatttgga aaacgtgtga tgcttctgtt atactacctg ttcgctcaca
     3001 ataagagaga acttttttac gaaaatctat tgaatatgcc ataaaaagat tataccacat
     3061 tgtgtactat attagattga aactagaata gtacacatct gcttctaaaa cattgttaga
     3121 aatcgatttg actgtcctta tttcatttta ctatattttt ggttcgcggg aagtctacta
     3181 agatacttaa agatgcagat agtaaaaaaa gatgtagaca ttaccgtaaa aaagtgatat
     3241 aattgtatga tgttcaaggt ataggtgtta atcatgagta gacgttttaa aaaatcacgt
     3301 tcacagaaag tgaagcgaag tgttaatatc gttttgctga ctatttattt attattagtt
     3361 tgttttttat tgttcttaat ctttaagtat aatatctttg cttttagata tcttaatcta
     3421 gtggtaactg tgttagtcct actagttgcc ttggtagggc tactcttgat tatctataaa
     3481 aaggctgaaa agtttactat ttttctgttg gtgttctcta tccttgtcag ctctgtgtcg
     3541 ctctttgcag tacagcagtt tgttggactg accaatcgtt taaatgcgac ttctaattac
     3601 tcagaatatt caatcagtgt cgctgtttta gcagatagtg agatcgaaaa tgttacgcaa
     3661 ctgacgagtg tgacagcacc gactgggact gataatgaaa atattcaaaa actactagct
     3721 gatatcaagt caagtcagaa taccgatttg acggtcaacc agagttcgtc ttacttggca
     3781 gcttacaaga gtttgattgc aggggagact aaggccattg tcctaaatag tgtctttgaa
     3841 aatatcatcg agtcagagta tccagactac gcatcgaaga taaaaaagat ttataccaag
     3901 ggattcacta aaaaagtaga agctcctaag acgtctaaga atcagtcttt caatatctat
     3961 gttagtggaa ttgacaccta tggtcctatt agttcggtgt cgcgatcaga tgtcaatatc
     4021 ctgatgactg tcaatcgaga taccaagaaa atcctcttga ccacaacgcc gcgtgatgcc
     4081 tatgtaccaa tcgcagatgg tggaaataat caaaaagata aattaaccca tgcgggcatt
     4141 tatggagttg attcgtccat tcacacctta gaaaatctct atggagtgga tatcaattac
     4201 tatgtgcgat tgaacttcac ttctttcttg aaaatgattg acttattggg aggggtagat
     4261 gttcataatg atcaagagtt ttcagctcta catgggaagt tccatttccc agtagggaat
     4321 gtccatctag actctgagca ggctctaggt tttgtacgtg aacgctactc cctagcagat
     4381 ggcgatcgtg accgtggtcg caaccaacaa aaggtgattg tggctatcct tcaaaaatta
     4441 acgtcaaccg aagcactgaa aaattatagt acgatcattg atagcttgca aaattctatc
     4501 caaacaaata tgccacttga gaccatgata aatttggtca atgctcagtt agaaagtgga
     4561 gggagttata aagtaaattc tcaagattta aaagggacag gtcggatgga tcttccttct
     4621 tatgcaatgc cagacagtaa cctctatgtg atggaaatag atgatagtag tttagctgta
     4681 gttaaagcag ctatacagga tgtgatggag ggtagatgag atgatagaca tccattcgca
     4741 tatcgttttt gatgtagatg acggtcccaa gtcaagagag gaaagcaagg ctctcttggt
     4801 agaagcctac agacaggggg tgcgaaccat tgtctctacc tctcaccgtc gcaagggcat
     4861 gtttgaaact ccggaagaga agatagaaga aaactttctt caggttcggg aaatagctaa
     4921 ggaagtggcg agtgatttag tcatcgctta cggggctgaa atttactaca caccagatgt
     4981 tctggataag ctagaaaaaa agcggattcc gaccctcaat gatagtcgtt atgccttgat
     5041 agagtttagt atgaacactc cttatcgcga tattcatagc gccttgagca agatcttgat
     5101 gttgggaatt actccagtca ttgcccacat tgagcgctat gatgctcttg aaaataatga
     5161 aaaacgcgtt cgagaattga tcgatatggg ctgttacacg caagtaaata gttcacatgt
     5221 cctcaaatcc aaactttttg gcgaacgtta taaattcatg aaaaaaagag ctcagtattt
     5281 tttagagcag gatttggtcc atgccattgc aagtgatatg cacaatctag acggcagacc
     5341 tcctcatatg gcagaagcat atgaccttgt tacccaaaaa tacggagaag cgaaggctca
     5401 ggaacttttt atagacaatc ctcgaaaaat tgtaatggat caactaattt aggagaaatg
     5461 atgaaagaac aaaacacgat agaaatcgat gtatttcaat tatttaaaac cttgtggaaa
     5521 cgcaagctaa tgattttatt agtggcactt gtgacaggtg cgggggcttt tgcatatagc
     5581 gcttttattg ttaagccaga atatacgagt accacgcgaa tttacgtagt gaatcgcgat
     5641 caaggagaca agtcggggct gacaaatcag gatttgcagg caggaactta tctggtaaaa
     5701 gactaccgtg agattatcct ttcgcagaat gtattggaaa aagtagcgac aaatttgaag
     5761 ttggatatac cagccaaaac gttagctaga aaagttcaag tgactgtacc agttgacact
     5821 cgtatcgtct caatctctgt caaggataaa cagccagagg aagccagtcg tatcgctaat
     5881 tctctacgag aagttgctgc agaaaagatc atcgctgtaa cgcgagtatc tgatgtaacg
     5941 acacttgaag aagcgcgacc agctacgact ccctcttctc caaatgttcg tctcaattcc
     6001 ttgtttggtt tttttggagg agcagtcgta acagtaattg ctgttctttt gattgagttg
     6061 ttcgacatcc gtgtgaaacg tcctgaagat gtcgaagatg tactgcaaat tccactttta
     6121 ggggtcgttc cagatttgaa caaaatgaaa taggaggaag ttatgccaac attagaaatc
     6181 tcacaggcaa aattggattt tgtaaaaaag gcagaggaaa attataacgc tttgtgcacg
     6241 aacctacagt taagtggaga tgatttgaaa gtattttcta tcacttctgt gaaacaagga
     6301 gaaggaaaat caacgacttc caccaatatt gcttgggctt ttgcgcgtgc aggttacaaa
     6361 acgctgctga ttgatggaga tattcgcaat tctgttatgt taggtgtctt taaagcaaga
     6421 gataagatta caggcctgac agaattttta tcaggaacta cagacctatc acaagggctt
     6481 tgtgatacca atatcgaaaa tctctttgta attcaggctg gctctgtgtc accgaatccg
     6541 acagctcttc ttcaaagtaa gaatttcagt acaatgcttg aaaccttgcg taaatatttt
     6601 gactatatca ttgtagatac tgctcctgtc ggtgtcgtga ttgatgcggc tattattacg
     6661 caaaaatgcg atgcttctat tttagtgacg aaggcaggtg aaataaatcg acgggatatt
     6721 caaaaagcaa aagaacagtt ggaacacaca gggaagccgt ttttgggagt tgtgttgaat
     6781 aaattcgata cttcagtaga caaatacggt tcttatggaa attacggaaa aaaataagtc
     6841 gttaagtatt tgtgtaagga catttttaga actacaatca aaatctttgg aattgctggc
     6901 ttcaaatcat attgatttga aatgaaactt gcaaaagagt tttttaggtg agtttcttaa
     6961 tttgtgactg aaatcaatct tctacttcca taccttggaa aaatagggta aacgagaaat
     7021 gttttttcca taataaagtt ttgatatggc tagtagagta gtaatataat agacttgttc
     7081 ggtaactgta aaaagtgtta tactattttt atggaaacag tatacgacaa agcacaaaaa
     7141 cttaactcaa aaaacttcaa actattgatt ggtgtcaaaa aggaaacctt tcaactcatg
     7201 ctagaacacc tgaattcagc ctatcagatt cagcaccgaa aaggtggacg tccacgtagt
     7261 ctgcccatgg aagaccagct cattatgacc ctccgttact tgcgatatta tcccactcag
     7321 cgtctgctgg cctttgattt tggcgtcggt gtagctacgg taaatgccat catcacttgg
     7381 gtggaggata cacttcgtgc gtcaggtagc tttgatttgg accatttaga agccccgagt
     7441 gctgctgtgg ctattgacgt gaccgaaagt ccgattcagc gtccaaaaaa aaccaaagca
     7501 aaaattattc tggtaaaaag aaacgacaca ccttaaaaac tcaaattatg ctggatttga
     7561 cgacacataa agtctgtcaa atggcctttt ctgacggaca tacgcatgat tttactctct
     7621 tcaaagaaag tattggacaa agtttgcctg aaacgacgct tgcctttgtt gacctaggtt
     7681 atttaggcat cttgaaattt catgagaata ctttcattcc tgctaaaaat tccaaaaatc
     7741 gccgcctgag tgaggatgat aagcagttaa ataaagagat gtcagcgata cgaattgaaa
     7801 ttgaacattt taacgctaaa ttcaagacct tccaaatcat gtcagtccct tatcgtaacc
     7861 gcagaaaacg tttcgagtta cgggcggaat taatttgtgc catcatcaat tatgaagtga
     7921 actagattcc gaacaagtct aatgaattgt aatcattagt gttcatacca agaaatatca
     7981 agtacctatt tttggaaatt ataaatgtta gatagtgttt aaatttttac ggagagattg
     8041 ttttgagagg taatttatgt atagggaaat aaaacgatta ggtgatattt tactttcttt
     8101 cataggaata atagtactgt ttccagtgtt tattataatt gcaatcgcaa taaagcttga
     8161 ttcaaaaggt ccagtaatat ttaagcaaaa gcgatttgga cttcataaga aatcgttcta
     8221 tgtcttgaag tttcgaacta tgaaggttga atcgccaaaa tatgtggcga ctcgagactt
     8281 agataaacca gaacagtgga ttaccaaagt aggagcttgt ttgcggaaaa catctttaga
     8341 tgaactgcct caactgtgga acattcttgt tggtgatatg agtgttgtag gacctaggcc
     8401 tgtagctata aatgaacttg atttgataaa agaaagagaa cagtatggtg ccaatgatat
     8461 cttaccagga ttaactggat gggcacaaat taatggacgt gataatttgt caacagagat
     8521 gaaggcagag atagatggtt attatgtaaa acatatgtcg ttaagaatgg atcttagatg
     8581 tatccttaga acaatcccct acgtattaaa acgtaaggga attgtggagg gtagtggtaa
     8641 gaaagagttg gagtgatgca atgaaaattc tatttgtttg tcaacattat aagccagaac
     8701 cttttagatt gtcagatatt tgtgaggatc tagttcaaag agggcacgag gtggctgttt
     8761 tgacagggat tcctaactat cccgaggggg aaatatatgc tgattatcgt aagagaaaaa
     8821 aaagaagaga gactataaat ggtgttgcta tttttcgttc atacaccatt gctaggaggc
     8881 aaaatacttt ataccgtata ttgaattatt ttagttttgc tctttcttct acgataggtg
     8941 ttatatttgg gcgttataaa gcgaaagatg gctcagattt tgattgtgtc tttgttaatc
     9001 aactatctcc agttatgatg gcttgggctg gtatagctta taagaacaag tacaataaac
     9061 ctatgttttt gtattgcatg gatgtttggc cggatagttt aattgtaggt ggggtgaagg
     9121 aaaatggatt gatttacaag atatttgaat ttgtttcaaa aaaagtatat caagccagcg
     9181 attatatatt tgttactagt ctatctttta aagattattt tgtaaaaaaa tttaatattc
     9241 ctctccacaa aattacttac ttaccacaat atgcagagga tttatttgta ccaaatgaat
     9301 taaaaacgaa caaaaatact attgacttaa cttttgctgg aaatattgga aaagctcaga
     9361 atttagagac tattttgaaa gcagccagtg caatagaaca gattcccgat ttagcaaaga
     9421 gagttcattt tcattttgtt ggagatggta cggaactatt aaacatgcaa aaattagcat
     9481 gtgaactaga attagagaac acttcatttt atggtagacg tccattagaa gagatgccgg
     9541 atttttatac aaaatcagat gcgatgctag tttctttaat aggcgactct ataatttctc
     9601 gcaccttacc aggtaaggta caatcttata tggcggcagg aaaaccaatt ataggagcga
     9661 tttcaggaga tactcagaga gttgtaaaag aagcaaaatg tggtttcata agtccggaag
     9721 ggaatgttga tcagttagtg agaaatattc gtaagttctg tttgctttct gtagaggaaa
     9781 gagagaaact aggaaggcaa gctcgttgtt gttatgaaga acagttttcg aaagagtggt
     9841 ttatgacata cttagaaaat catttaaaag aggggtttct atcatgaagg ttttaatgat
     9901 taattccgtt tgtggtatta ggagcactgg gagaatttgt acggatctcg caactgcttt
     9961 gacagaagaa ggatatgagg ttaaaatcgc ctatggtcgt gagtatgttc cgaaacaatt
    10021 tcaacagtat gcagtgaaaa ttggtacaaa gtctgatatt cgttttcatg cgattcgttc
    10081 tcgattattt gacgaatctg gctttggaag tagacaggca actgttaatt ttattaaatg
    10141 gataaaagag tttgaccctg atgttattca tcttcataat cttcatggat attatatcaa
    10201 tattgaactg ttatttgatt atctccgtat atgcggtaaa aagattatat ggactttgca
    10261 tgattgttgg gcatttacag gacactcggc tcactttgat tgtttggaat gtgagtcaaa
    10321 gggggtttgt gaccatccat ctcagaaaaa tgattatcct aagtcgttcg tgaatttttc
    10381 aaagcgaaat tatcaaagga agaaaaaatg ttttacacat attcctaatc tcactattgt
    10441 tactccttcg caatggctag ctaacttggt aggacagtca tttttaaaag aatatccagt
    10501 gaaagtaatt cataatggca ttgatactac tgtctttcaa ccgaggctaa tagccgctca
    10561 aaagttgaaa aaaagatacc atcttgaagg aaagcaggta ttgcttggtg tggctgctat
    10621 ctggactgat aaaaagggat tttctgatat gttagtcctt gcgagtcatc tagctgataa
    10681 tcagagaata gttttgatag ggttaaaaga taggcaactc aaaaaattac ccaaaggtat
    10741 tattgggcta acagagacta atagtccaga agagttggca gcatggtata cactagcgga
    10801 tgtattctta aatcctactt atcaagatag ttacccgaca actaatttag aagctatttc
    10861 ttgtgggaca ccagttatca gctatccgac aggtggtagt gtagaaagtg ctaaacttta
    10921 tggtctcgtt tgtcaggata gaaacgtagc ttctatttta tcttcgttag aaaaagtctc
    10981 tcagctatct aaaacagaaa aattagattt ttcaattgca agttttatta aacaaatgaa
    11041 atatttatac tagaacttga attataggaa aatgaggaat ttgcattaaa atgatgaaaa
    11101 gaatttatta tcaccttttg gctattttgg cttggactct tccaaattct tatgctttta
    11161 ttgattcgtt aaaggtgttt tttccgaata ttagtttaca aattgcaggt tctcttttgg
    11221 ctgttatctc gataggaatt tttatcacta gaatatatta tacaggatac gaagttttta
    11281 tatctctatt ggtttgtatt tttattttaa ttttttattc aactcgcttt ttttattcga
    11341 ttaatgtaga gttgtatcag tctttcttca attcctttct gattcgtcca gttcctggga
    11401 tattagtagc gatgctgtta gctaagaata atcatataaa aggtttcata aaatggtcag
    11461 aacctatgat gcttttctat acattgacat catttttagc agccctatct cctagaaata
    11521 gcattattat ttaccaatct ttatcttatt atgccatgac agcttatatg attaatgtgt
    11581 ttaatattat atacaaagag aaaatattgg aggagcaact gacgtatttc agattctcag
    11641 cgtggaattt tattagatat tttttacttt tgattcaagc ttttaatgca ctctcaggag
    11701 gtgggagagg tgcctttatc ttattaatta tttttacagg aatattatta ataagaattg
    11761 ctatgaattt taagttcctt ttctcattca ttggaggctt atctgctata gctctagttg
    11821 ttttttgtat aaaagatttg gatttcacat ggctcttgaa tatggacggt ggagagcgat
    11881 tgttgaactt cttcggcaga cctgaacgta tatctacaga taatagacta ttgatttatg
    11941 atactgtttg gtctgcaata caggaaaaac cctttttagg atggggagtt ggttcaactt
    12001 ttttaaaatt taatggatat tcacataata ttgtattgga tttattgcat gatatgggaa
    12061 gttttggttt attaattatt ctttcggctt tctttgcttc ttcagtaata ttgtacaaat
    12121 tacgtaaaat agattggaaa gtgaatttat ttattctgat gtttctagaa gtatatgttc
    12181 acatgagttt cagtggaagc tatcttgcag atggtagact atggtttttg gtgatcttta
    12241 cttattgtta ctacaggtgg aaagtgcagg aaaaggatga agttagcaat tttattatct
    12301 gatatttcaa aaataggagg agtgcagcgt gtcacgacag ctcttgttaa tgaactttgt
    12361 caaaatatag acgttacaat tatcagcatc ttttcggaaa atgagctacc agcttttgga
    12421 ctttcagata gagttcaggt gagctatctt ttgaaagaac atgttaattt gaagaagaat
    12481 ttttttaaag ttagtggagc tttgcgaaaa gtgttgaaaa aacagcagtt tgatgttgtt
    12541 ctatcgtcag gaactggtct agtatccttt ctttggtttg ctagtttggg aattcctacc
    12601 agacttttgg catgggaaca tcagtgtttt tactttggga gatcgtttgg tctagagtgg
    12661 ttggggcgaa agctagcctg tcgttttgct gagagtattg ttgtcttgac taaaaaagat
    12721 gaaggatttt acaaagagaa tcgtcctaag gctcatattg aacaaatcta taatatccta
    12781 gacatggatt cacaaacagc taagtgtcag ctctcttcta aaaaaattat cagtgttggc
    12841 tctttaggac gacaaaaagg ttttgatctg gctcttgagg tagctagtca aatacaatta
    12901 agttatccag attggcagtg ggacatttat ggtgatggcc ccgatagaga aaaattagag
    12961 gagaaagtca gggaatacca attagaaggc tttataaatt tgaaagggct tgttcagaat
    13021 gttcgggagc tctatcctga ctactctatc tacgccttga catcacgata tgaaggatta
    13081 tcaatggcat tattagaagc taaaaactgc cagatgcctg ctatttcatt tgattgtaac
    13141 tgtggaccct ctgatattat ttcagatgga agaaatggtt ttttgattga ttgttttgat
    13201 gtaaatatct atgcaaaaac tttatctaaa ttaatgacta gtttagagtt gcgagaacaa
    13261 gttgcaaaat cgagtgttat tccagcagaa gaattgtcaa caacctatat cctagataag
    13321 tggaacaatc tattaaagat agaaagaaga taatatgaaa atagtccatg tagaagattt
    13381 ttttcatcca gatgcaggtt accagattaa tgttttacca aaatatctag caaagtttgg
    13441 tcatgaacaa gtgattatca cttcagaaat ggataaaatc cccgataatc ttacccaatt
    13501 ttttggacga gaaaatatag aagagagaga tagaagttac gaagagaagc atcatgtgaa
    13561 gattattcgc ttgcctcttc atggatttgt aagcggacgt gcgatttttt ctggaaagct
    13621 tatttcggct attaagggtc tttctccaga ggtattgtat attcatggga atgacacttt
    13681 aacagggatt cgtctccttt tagctcgaaa gaaacttaat tgcagaatcg tcaccgatag
    13741 tcatatgctt gaaatggcat caagaaatcc tttcaacaac tactttagga gattttataa
    13801 aaccttgatt actcccattt tgataaaaga acagatacca attattcgga cgcaagatga
    13861 taattatgtt gaaaaacact tgggaattcc tttatcgcaa gctccatgga tttcttatgg
    13921 gtcggataca gcgttctttc acgcagatag ccagattaag gaagattttc gttctcagta
    13981 tcaaatcgct tcagatgctc ttatttgtgt ttacgcagga aagttagatg agcataaggg
    14041 tgggatgttt ttagcagagt ctctaagtaa aaagttaaat acggagcaac caattgtttt
    14101 cattatagtg ggtaatacaa atggagagta tggagaagct gtcgagaaaa gtttctccca
    14161 atctgaaaac caaattttgc gctttccgac tcaaaaatat caaaaattag cacagttttt
    14221 tcaggtagca gattttgctt tatttcctaa acaatgtagt ttaagttttt atgatgcaca
    14281 ggcctgtggt ttaccagttt tattggaaga taataatatc aacctcgata gaacttctca
    14341 ttataatggt tggacgttca aggctaacag caaattaagt ttgagagatt cattaaaaat
    14401 gattgcgagt ctagataaag agaagagaca agagtactct cagaatgcac tgcactatat
    14461 ccttgaacat tataattatg aagataaagc aagagaatat gaaaagattc ttatagggga
    14521 acgtacgaaa tgagatagtt aatatttcgt tattttatag gaaaggtgga tttaatgaaa
    14581 atttgcattg tttcagtcgg agtgggcgga ctaccgattc cagctgtaaa agggggagca
    14641 gtagaaaatc tcattgataa ttatttaagt tacaatgaga aatataatca tgatgaaatt
    14701 acggtcgtta gttgtgacca taaggaggcg cgtgaggctt caaaaaaata caagtatgcc
    14761 caatttgtct atatagatat tcattcactt aaatataaaa taaacaaaac aatacgttat
    14821 gccattaata aatattcacc tttcttcgta gggaacgctt atatcagtca attgccagac
    14881 ttgtctggtt ttgatacagt tttgattgaa aatcgccctg aatacggtta ttatattcgt
    14941 aaaaagttta aaggaaatct tgttttacat cttcacaatg atttattaat ggacaatgag
    15001 tattctgtag attatagcgt ttatgataaa attatcacaa tatctgacta tattagggat
    15061 aggtcagaag tagtaacgtc aggtgttccg atacagactg tctataatgg tattgacaca
    15121 gaactttttt tgcagaattt ctctgaaatt gatttatcag atcttaaaaa tcagttggaa
    15181 attttgtcgg atgattttgt gattgttttt tttggacgta tcaacaaaaa taaaggtatc
    15241 aaagaactgc ttgaagcctt cttgttgata ccaaagaatt tgaatataaa attactagct
    15301 gttggtagtt ctatatttgg tcagacggag ttggatactt tcacaacaga gctacggcaa
    15361 ttggcaaaac aagcatcaga taaagttgtt tttacaggct atgttaatta caaagacatt
    15421 cctaagtatc atcatattgc agattgcatt gttgttccat ctatttggga ggaaccagcg
    15481 ggtttgacgg tctgtgaagc tttgatatca gggaaatatg ttattacaac agatgctgga
    15541 gggataccag agattgtagc tggcagtgaa gcccttgtgg tagcaaatga tgagtgtata
    15601 gttgaacacc tcaaaacagc cctattgagt gtctaccaaa aagggaaatg ctcttcggtt
    15661 attacttcta atagagatag aggagcctat ttttctattg aaaaatatgg aagagactta
    15721 cggaaagagc tcacacaaaa tgaaagaatc attaacatat gagtcgtgta aaaaatagtt
    15781 tttttaatat tttagctgga atagttggta ctatcatatc gagtgtttta gctttcatag
    15841 ttagaacagt gtttatccga gttttgggag agacttatct aggtttcaat ggtctataca
    15901 ccaatatctt aacagtttta tccctaactg aattagggat cggatcatca attgcttatt
    15961 tgatgtacaa acctttagca gaaaaagatg gggacaaatt agctcaagta gttcaattct
    16021 ataaaaaaat atatcgagtg attggtatca ttattcttat tttaggtttg tgtctcgttc
    16081 cttttttacc agtcattgta aatttaaaaa atgcagaaga tttgaactat acagcattgt
    16141 atttgcttta tttagcagat acagtttcta cttatctatt ctttgcatat aaaagagggg
    16201 tattggctgc tgatcaaaag atctatgttg cgaatatctt tgatataatt ataacgacaa
    16261 ttttatctat tttccaaatt atcactttga tgatttttaa agacttttat ctatatatta
    16321 ttttaaaaat tgctaaaaat cttactttga acctagtaat tagtttaaaa gtagataaaa
    16381 tgtatccaag tattcataaa tttaaaggga tagctccgct tccaaaaatg gaaagacgac
    16441 tagtttggaa aaatgtatat gctacctctg ttcgacaaat ctttaacgaa ttaatgaatt
    16501 caacagatag tatagttatt tccattgtct taggaatagt tatggttggt aagtattcga
    16561 actatgctta tattttatca atcgtatata ttttctttgg aggaattttt aatccgattc
    16621 aggcttctat tggaaaccta tctctgtcag cttctataga gaaaaaaaat gaaatcttca
    16681 atagattacg ttttataaat tttttctttt tatcattttg ctcaagttgt cttctagtat
    16741 tggtaaatcc ttttatcact atttggattg gagaaaatta cactttatca tttacaggtg
    16801 tgattgcaat agttggtatg ttattcgtta gacaaactgg aaattgtaca accatttttc
    16861 gtttgggaga aggatatttt agagattatc atttttctcc tttaatcgcg ggcattttaa
    16921 atttagttgt ttcagtaatt ttagtgaatt atataggtat tgcaggtgtt tttgttggaa
    16981 caatgttagg atttggtttc caatttatac tggtggatac aattgttact tataaaaaag
    17041 tacttagtcg tccactatca gagttttatt taagatggtt gcagacgatc ttattaactg
    17101 taggtttatg tattgcgagt tactatttat ctcgattggt tagagtgaat agtatatatg
    17161 atttgatact gttgtttgta gtggttattg gatttaattt ttttgcttta tgttttattt
    17221 attggcgaaa tgatgatttt caatatttta ttcaattggt taaaaatttt atgaaaaatt
    17281 tggaggaaaa aaatcatgat taatgtaatc ggattaggtt atattggatt gccaacaatt
    17341 ttaatgttgg caacaaacgg cgtgaaagta gttggaactg actacaatca ggatttggtg
    17401 agaactttaa atgaaggtca aacaaccttt aaagaagatg gattggatga actatttcat
    17461 aaagcagtgg agtcgggtgt ggactttaca accgaatatc aacaaacgga tacctatatt
    17521 atttccgttc caacaccata tgactccttc tctaaaaaaa ttgatccaag ctatgtgatt
    17581 gaagctacga aaacggtact tgataattgc aataaaggag cggttattat tattgaatcg
    17641 accgtatcac caggaacggt tgataaattt attcgacctg ttgtagaaga aaaaggtttt
    17701 gttattggta gtgatattca tcttgtccat gctccagaac gtattattcc agggaatatg
    17761 gtctatgaat tggtgaataa taaccgtaca attggagctg atgacctaga aatcggctat
    17821 aaagtgaaag agctttatgc ttcattttgt aagggcgata ttgttgttac agatattaga
    17881 actgcggaga tgaccaaggt agtagaaaat acatttagag ctgtaaatat tgctttcgct
    17941 aacgaattag cacagatctg tagttatgat aatatgaatg tttatgaaat tatccggatc
    18001 tgtaatatgc acccacgggt aaatattcta caacctggac ctggtgttgg tgggcattgt
    18061 atttctgtgg atccttggtt cttagttgga gattatcctg agttgacaaa tgttattgaa
    18121 cattctatgc gaacaaatgc tgccatgcca gaatttgtat taaatcgtat ctataccatt
    18181 atgaacgaac atcatctaac agatattagt cgggttggtc tatatggtct tacctacaaa
    18241 gagaatgtag atgatatgcg tgaatctcca acgcttcagt tattagaatc tatgagccgc
    18301 catctggcaa cacctgctat taaagtatat gatccattta tagaaaaaga tgttgtggcg
    18361 aatcagtcac atgatttaga tgaattttta tctaatgttg atattgttgt actgttggtt
    18421 ggtcatgatg agattttaca aaatatggat aaactaaaag ataagatagt gttagataca
    18481 cgttatatct gtcatcttga tggaacttac agattataat tagtgataaa taaagtaagg
    18541 attgactatg aaaaaaatag ttgtaatttt cggaactcgt cccgaagcta tcaagatgtg
    18601 tcccttggtt aaagagctaa gaacacgtga gaatcttgaa acattggtct gtgttacggg
    18661 tcaacatcgt caaatgctgg atcaagtttt ggatactttt aggattacgc ctgattttga
    18721 tttatctatt atgaaggaca aacaaactct ctttgatgtc acaattggca ttttggaagg
    18781 catgaagact gtcttagagt cagttaatcc tgatttaata ttagttcatg gggatacgag
    18841 tacaacattt gccagttcac tggccgcctt ttatctacag attccaattg gacatgtaga
    18901 ggctggtttg cgtacttatg atatttattc accttatcct gaagaattta atcgtcaagc
    18961 agtaggtgct ttggctcagt atcattttac accaacacaa ctctcaaaag acaatctctt
    19021 gagagaagga aaaaattctg aagctatatt tatcacaggt aacacagcaa ttgatgcttt
    19081 acaaactaca attcaagagg attatactca tcctgagtta aattgggttg gggatagcaa
    19141 actaatatta attactgctc atcgtcgtga aaatattggt gacccgatga ggcacatgtt
    19201 tagagcaatc cgacgtatca ttgaagaaca ttcggatata aaggctcttt accccattca
    19261 tatgaatcct ctagttcgtc agattgctga ggaagaacta agcggatgtg aacgtatcaa
    19321 aatgatcgat ccgttggaag tattagattt tcataacttt ttatcacgga gttatctcat
    19381 tttaacagat agtggtggta tccaagaaga ggcacctagt ttaggaaaac ctgttttagt
    19441 tatgagagat acaactgaac gtccggaggg aattaaagca ggaactttga agcttgtagg
    19501 tactgatgag gacaatattt atagacattt taaagaattg ttagaaaatg atttagttta
    19561 tcaagcgatg agccaagctt caaatccgta tggagatgga acagcttgca agaaaattgc
    19621 agacatacta gaaggagaag tataatatat gtcacaattt acaggaaaaa ctctcctaat
    19681 tacaggagga acaggttcat ttggtaatgc tgtccttaat cgttttttac agactgatat
    19741 tggtgaaatt cgtatttttt cccgtgatga aaaaaaacag gatgatatgc gtcatgagtt
    19801 tcaggtaaaa gtaccagaag tagctgggaa aatccgtttt taccttggag atgtgcgtga
    19861 cttagcttcg gtaaaaaatg ctatgcatgg tgtggattat gtttttcatg ctgctgctct
    19921 taaacaagta ccttcgtgtg aatttttccc tgtagaagcg gtaaaaacta acattttggg
    19981 aacggagaat gtcctcactg cggctatcga agctggtgta aagcaagtta tctgtctttc
    20041 tacagataag gcggcttatc ctgtcaatgc tatgggaaca tccaaggcta tgatggaaaa
    20101 gattgctgtt gctaagtcca ggacggtaaa tcctgagcat acaaagatat gtgtgactcg
    20161 ctatgggaat gttctgtgta gccgtggatc tgtcgttcct ctttggattg agcaaattaa
    20221 gcaaggaaat gctcttacaa ttactgaacc tagcatgaca cgttttgtga tgacattaga
    20281 agaagcagta gacttggttt tatttgcatt tgaagaaggg aaatctggag atatactagt
    20341 tcagaaagca ccagcatgta cgattgaagt gttggctaag gctgtatcag aaatttttgc
    20401 ctcagaacaa gatattaaga ttataggtat tagacacgga gaaaaaaggt atgaaacact
    20461 attaactaat gaagagtgcg caaatgcaat tgatttgggt gatttttata gagttcctag
    20521 tgataatcgt aatcttaact atgataagta tttcaaagat ggtagtacga atagaaattt
    20581 gttgacagaa ttcaatagta ataataccga tttgatggat gtagagcaag ttaaaagaaa
    20641 gttgctagaa ttagatgaaa tacagacagc aattcgtgat atggtagcag atgaagagat
    20701 gtaaaatctt ttaagataca ttaaaattat caaggatata taatgtatca tgtattgtcg
    20761 agagagttga ctattaaaac agcatataaa acaaggaggg ggcatgatta aaaatatttt
    20821 aatcacagga gcgaaaggat ttgtaggaaa aaatcttatc tgtactctgg aagctttgaa
    20881 agatggacga gataggactc gtcctaattt agagattgga gagatttttc agtatgatcg
    20941 tgatacagat ccgattttat tagatgaata ttgtaagaag gccgatttcg tattccattt
    21001 agctggtgtc aatcgtccac agaatcctga tgaattcatg gagggaaatt acggtttttc
    21061 aagtagatta ttggagattt tagaaaagta tgaaaacact tgtcctgttc tactctcaag
    21121 ttctactcaa gctagtttag aaggccgatt ttcaaactct atatatggac aatctaagct
    21181 agcaggggaa gaactcttct ttgaatatgg aaagaaaacg ggagcacctg tcttagttta
    21241 ccgtttcccg aatctttatg ggaagtggtg ccgtcctaac tacaattctg ctgtagcaac
    21301 tttctgtcat aatatagctc acgatttacc tattcaagta aatgatccaa gtgtagaatt
    21361 ggagttgctg tatattgatg atttgataca agagtgtcta actgcattgg aaggaaatcc
    21421 tcatcgttgt aatctagatg gattacaaat cttacctagc ccatcaggaa actactgcta
    21481 cgtaccaacg actcatcgtg caaccttagg agagattgtc tctctattag aaacatttaa
    21541 aaaacagcct aatagtttag ttatgcctga aattcctcaa ggatcgttta aaaagaaatt
    21601 gtattctacc tacctatctt atttaccagt agataagttt aggtttcctc taaaaatgaa
    21661 tatagatgaa cgaggtagtt ttacggaatt attaaaaaca gaaaatacgg gtcaattttc
    21721 tgttaatatt tctaaacctg gcattaccaa agggcaacat tggcatcatt ctaagtggga
    21781 atttttcatg gttgtttctg gtcgtgcttt aatacaagag cgtaggatag ggctggatga
    21841 aaacggtcaa gagtatccta ttctgaactt tgaagtgtcg ggcgataaga ttgaagcaat
    21901 acatatgata ccgggctatg cacataatat tattaatctt tctgatacag aaaatctaat
    21961 tactgtcatg tgggctaatg agtcatttga tcctagacat ccagatactt tttttgaaca
    22021 agtggagaaa taaatgaaaa ttaagacaga ttatagtgat attcatttta aagataatgg
    22081 caaacttaag ttattgatta ttgtgggaac acgtccagag attatacgtc taagtagtgt
    22141 tatcactaaa tgtcgaaagt attttgatgt tattttggca catactggac aaaactatga
    22201 ttacaattta aatggtattt tctttgataa tttagggtta gacactccgg acgtatacat
    22261 ggatgctgtt ggagatgatc ttggtgctac tgtagggaat attattaata cttcatacaa
    22321 attgatgaat caaattaaac cagatgcttt attgatttta ggggatacaa attcttgttt
    22381 atcagctatt gctgccaagc gtttacatat tccaattttt catatggagg ctggcaatcg
    22441 ctgtaaagat gagtgcctgc cggaagagac taatcgtcgg attgttgata ttatttcaga
    22501 tgttaactta gcatactctg aacatgcacg taagtattta catgagtgtg gtttacctaa
    22561 agagcgcaca tatgtaactg gttctcctat ggcagaagtg ctacataaaa atttatctgc
    22621 cattgagtct tcagatatcc atgaacgttt gggattgaaa aaaggaggtt atatcttact
    22681 ttcagctcac cgtgaggaaa atattgatac agataaaaat tttatttctc tctttacagc
    22741 aattaatcaa ttagctgaaa agtataatat gccaatctta tattcttgcc atcctagatc
    22801 aaagaaaagg ctacaagaga gcggttttaa actagataaa cgtgtgattc agcatgagcc
    22861 actaggattc catgactata attgtttaca gatgaatgca tttgttgtag tatctgattc
    22921 gggaacttta ccggaagaaa gtagtttctt tactagtcaa ggttatcctt ttcccgctgt
    22981 atgtattcgt acaagtacag aacgtcctga gtccttagat aaggcaggat ttattttggc
    23041 aggcattgat gaaaattctc ttcttcaagc agttgaaact gctgttagct tggcagaaga
    23101 tgaggatttt ggattaccgg ttccagatta tgttgaggaa aatgtctcta ctaaagttgt
    23161 taagataata cagagctata cagggatagt ggataaaata gtttggagga aaagctgaat
    23221 tgtatatttt taataaatca aaacgagatg attaattctt agtagaacaa gagtaaaatt
    23281 gaacgtattt gatggaaatg tcttacttga tagtcgaggg atagccattc tatcggattt
    23341 ttggcttgtt tttgcgcttc atgtttgata gaataaaggg ctctttgtca actgtagtgg
    23401 gttgaagaaa agctaagctt gagaaaggac aaatttcgtc ctttcttttt tgatgttcag
    23461 agcgataaaa atccgttttt tgaagttttc aaagtttcga aagtaaccgc ccaataacga
    23521 agtatattga aaaatctcca gactagagaa ctcacggata gttcctaatc tggagatttc
    23581 ttatttgcac ttttcttgta caactttagt ccatggtaaa taagcctcta aaacctcttt
    23641 gtttacgaga gtttcctcgt ttggaagaca ttctagaaga taggatagat atttctcgct
    23701 atttataatg gattgaaata agatatgaac aaatcgatta ggaaaggaaa attgatttat
    23761 agaaatgttt tagcagtcga tgcgtactgt tatagattca acgcactata attgatgacg
    23821 tttagctgtt tccaacaagc tcataataat agctcttgct ttagctcctt caaaactttg
    23881 agaaaataac caccctcgct tttttaaact gagctcaggc taaaagagtc cactggactc
    23941 ttttactccg tcccataacc aatgatttaa tggcgcgttc agctagatta ttggaaagga
    24001 ccagatgtcc gtctttcaaa atagtcttaa aggtttcttc atacttgagg ctgtattcaa
    24061 ttgcccttcc tagttttgaa cctgctaaaa ctgactgacg gcggcaccaa gcaaagaagt
    24121 cttccattag gggctggaga tgttcttgac gtttctgtag tcgttcatca gctggcaaag
    24181 cctcccagtc tctttccaag gaaaataact gatcacaata ggctaaacct ttagctccta
    24241 aggatgattt atctgcttgg gggtcgcttc aaaaaacttc cttctcacat gtgcccaaca
    24301 tccaacaagt gcagcttctt ccagttgacg ataagcttct agcggttcgc agtttaccaa
    24361 gcttagcgtc gccttgctcc taaaccttgg actgctatcg cataggcaga actagaggac
    24421 taaagtccta agttactgcc gcaacatgtc acaatgaaca tagccagaat aatctcctag
    24481 gaattcttgt actactaaac cactccgacg ctgatcatgg tggtacagcg tgattgcttg
    24541 attctcagct ttcccagaca aaaaggtcca atagtaagtc agctgactat cactctctag
    24601 caccctataa gaagtttcat ctgcatgaag taagggcttg agtcaatagt ctcgttataa
    24661 aggggcttta ggaataggag ctttcacaag cttatccaga tgattatctt ttactcgtta
    24721 tggacaatgc tatatggcat aaatcaagta ccttaaagat tccgactaat attggtttta
    24781 cctttattcc tccatacaca ccagagatga accccattga acaagtgtgg aaagagattc
    24841 gtaaacgtgg atttaagaat aaagcctttc gaactttgga agatgtcata caaggactgg
    24901 agaaggaggt gataaagtcc atcgttaatc ggagatggac tagaatgctt tttgaaagca
    24961 gatgagtata aaaagaaagt cctcatttca atagaaatca cgactttctg atggatttat
    25021 agtaaaatga aataagaaca ggacaaatcg atcaggacag tcaaatcgat ttctaacaat
    25081 gttttagaag cagatgtgta ctattctagt ttcaatctac tatatttttg gagtgataga
    25141 aaagcccttc atcagccaat ctacttgttc aggtgcgaga gctttgacat ccttttctgt
    25201 actgggccaa gtcagtctgc cgttctcaaa gcgtttatat agtagccaaa atccttgacc
    25261 atcccagtaa agggctttaa agcggtcttt acgtccacca caaaagagaa aaacttgacc
    25321 tgagaaagga tctaattcaa agtgggtttt aaccagataa gccagtgaat caatgccttg
    25381 cctcatatcc gttttcccac atacgagata gacctgccct aggctagata gatgaattgt
    25441 catagagcaa caccttatcc aaaagctgtt ctatcatttc gagattgaga gattgaaaaa
    25501 aacttacttc aagcttgcca atacgaattt taagcagaat atcatttctc tttttagaat
    25561 caaaaggacg agattgtgga atctctacag gaacaatagg ttgtggcatt aaaatatcct
    25621 ccaatagttt tactttacta atagtataca ggaggagctc catgaatgat agataccttg
    25681 ttatgacgcg cttactaaac aactaactga tgcacgattt aagcgccttg ttggtgttca
    25741 gcgcacgact tttgaagaga tattagctgt attaaaaaca gcttatcaac ttaaacacgc
    25801 aaaaggtgga cgaaaaccta aattaagcct agaagacctt cttatggcca ctcttcaata
    25861 tatgcgagaa tatcgcactt atgaacaaat tgcggctgat tttggtatcc acgaaagcaa
    25921 cttactccgt cggagccaat gggttgaagt aactcttgtt caaaggtggt gttacgattt
    25981 caagaactcc tctcagttct gaggacacgg taatgattga tgcgacggaa gtacaaatca
    26041 atcgccctaa aaaaacaatt agcgaatcat tctggtaaaa agaaatttca cgctatgaag
    26101 gctcaagcga ttgtcacaag tcaagggaga attgtttctt tggatatcgc tgtgaactat
    26161 agtcatgata tgaagttgtt caaaatgagt tgcagaaata tcggacaagc tggtaaaatc
    26221 ttggccgaca gtggttatca agggctcatg aagatatatc ctcaagcaca aactccacgt
    26281 aaatccagca aactcaagcc gctaacagct gaagataaag cctgtaacca tgcgctatct
    26341 aaggagagaa gcaaggttga gaacatcttt gccaaagtaa aaacgtttaa aatgttttca
    26401 acaacctatc gaaatcatcg taaacgcttc ggattacgaa tgaatttgat tgctggtatt
    26461 atcaatcatg aactaggatt ctagttttgc aggaagtcta ttgaaggatc ttttgcttta
    26521 gttccttggt caaggttgat tattttcacg gagcgcttcc gattgttttc ataaaccatt
    26581 tgcgcatagt cagcagaata aatctttttg aaacgtccct ttcctagaca ttatagaact
    26641 ttcagattca tctgaattta ccaaatcaac acaaaaattc tgaaaattct gttgacatct
    26701 ttctgaaaag agtctataat ggagagaaag ttttaaagga gaaaatgatg aaaagttcga
    26761 aactatttgc ccttgcgggc gtgacattat tggcggcgac tactttagct gcatgctctg
    26821 gatcaggttc aagcactaaa ggtgagaaga cattctcata catttatgag acagaccctg
    26881 ataacctcaa ctatttgaca actgctaagg ctgcgacagc aaatattacc agtaacgtgg
    26941 ttgatggttt gctagaaaat gatcgctacg ggaactttgt gccgtctatg gctgaggatt
    27001 ggtctgtatc caaggatgga ttgacttaca cttatactat ccgtaaggat gcaaaatggt
    27061 atacttctga aggtgaagaa tacgcggcag tcaaagctca agac
//
