LOCUS       CR931659               23673 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain Gambia 1/81 (serotype 12b).
ACCESSION   CR931659
VERSION     CR931659.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23673)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 23673)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..23673
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Gambia 1/81"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC12B_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC12B_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI33242.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            293..458
                     /gene="aliB"
                     /locus_tag="SPC12B_0002"
                     /pseudo
     CDS             293..458
                     /gene="aliB"
                     /locus_tag="SPC12B_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(459..980)
                     /gene="tnp"
                     /locus_tag="SPC12B_0003"
                     /pseudo
     CDS             complement(459..980)
                     /gene="tnp"
                     /locus_tag="SPC12B_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1203..2648
                     /gene="wzg"
                     /locus_tag="SPC12B_0004"
     CDS             1203..2648
                     /gene="wzg"
                     /locus_tag="SPC12B_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33245.1"
                     /db_xref="GOA:Q4K1Y5"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y5"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLICFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLLFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYESKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIINSLQDSIQTNVPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1203..1319
                     /gene="wzg"
                     /locus_tag="SPC12B_0004"
                     /note="Signal peptide predicted for SPC0578 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    1407..1754
                     /gene="wzg"
                     /locus_tag="SPC12B_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 3.7e-63"
     misc_feature    1932..2375
                     /gene="wzg"
                     /locus_tag="SPC12B_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 8.4e-70"
     gene            2650..3381
                     /gene="wzh"
                     /locus_tag="SPC12B_0005"
     CDS             2650..3381
                     /gene="wzh"
                     /locus_tag="SPC12B_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33246.1"
                     /db_xref="GOA:Q4K1Y4"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y4"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLVEAYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKSKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    2653..3261
                     /gene="wzh"
                     /locus_tag="SPC12B_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 9e-37"
     gene            3387..4082
                     /gene="wzd"
                     /locus_tag="SPC12B_0006"
     CDS             3387..4082
                     /gene="wzd"
                     /locus_tag="SPC12B_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33247.1"
                     /db_xref="GOA:Q4K1W4"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K1W4"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILLVALVTGAGAFAYSAFI
                     VKPEYTSTTRIYVVNRDQGDKSGLTNQDLQAGSYLVKDYREIILSQNVLEKVATNLKL
                     DIPAKTLARKVQVTVPVDTRIVSISVKDKQPEEASRIANSLREVAAEKIIAVTRVSDV
                     TTLEEARPATTPSSPNVGRNSLFGFFGGAVVTVIAVLLIELFDIRVKRPEDVEDVLQI
                     PLLGVVPDLDKMK"
     misc_feature    3387..3503
                     /gene="wzd"
                     /locus_tag="SPC12B_0006"
                     /note="Signal peptide predicted for SPC0580 by SignalP 2.0
                     HMM (Signal peptide probability 0.729) with cleavage site
                     probability 0.460 between residues 39 and 40"
     misc_feature    3408..3824
                     /gene="wzd"
                     /locus_tag="SPC12B_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.4e-54"
     misc_feature    3930..4007
                     /gene="wzd"
                     /locus_tag="SPC12B_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4092..4766
                     /gene="wze"
                     /locus_tag="SPC12B_0007"
     CDS             4092..4766
                     /gene="wze"
                     /locus_tag="SPC12B_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33248.1"
                     /db_xref="GOA:Q4K1Y2"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y2"
                     /translation="MPTLEISQAKLDFVKKAEENYNALCTNLQLSGDDLKVFSITSVK
                     QGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITQKCDASILVTKAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGKK"
     gene            5113..5712
                     /gene="wciI"
                     /locus_tag="SPC12B_0008"
     CDS             5113..5712
                     /gene="wciI"
                     /locus_tag="SPC12B_0008"
                     /note="member of homology group 29"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33249.1"
                     /db_xref="GOA:Q4K1Y1"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y1"
                     /translation="MYREIKRLGDILLSFIGIIVLFPVFIIIAIAIKLDSKGPVIFKQ
                     KRFGLHKKSFYVLKFRTMKVESPKYVATRDLDKPEQWITKVGACLRKTSLDELPQLWN
                     ILVGDMSVVGPRPVAINELDLIKEREQYGANDILPGLTGWAQINGRDNLSTEMKAEID
                     GYYVKHMSLRMDLRCILRTIPYVLKRKGIVEGSGKKELD"
     misc_feature    5113..5205
                     /gene="wciI"
                     /locus_tag="SPC12B_0008"
                     /note="Signal peptide predicted for SPC0582 by SignalP 2.0
                     HMM (Signal peptide probability 0.855) with cleavage site
                     probability 0.449 between residues 31 and 32"
     misc_feature    5128..5682
                     /gene="wciI"
                     /locus_tag="SPC12B_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 1.4e-36"
     gene            5717..6943
                     /gene="wciJ"
                     /locus_tag="SPC12B_0009"
     CDS             5717..6943
                     /gene="wciJ"
                     /locus_tag="SPC12B_0009"
                     /note="member of homology group 35"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33250.1"
                     /db_xref="GOA:Q4K1Y0"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1Y0"
                     /translation="MKILFVCQHYKPEPFRLSDICEDLVQRGHEVAVLTGIPNYPEGE
                     IYADYRKRKKRRETINGVAIFRSYTIARRQNTLYRILNYFSFALSSTIGVIFGRYKAK
                     DGSDFDCVFVNQLSPVMMAWAGIAYKNKYNKPMFLYCMDVWPDSLIVGGVKENGLIYK
                     IFEFVSKKVYQASDYIFVTSLSFKDYFVKKFNIPLHKITYLPQYAEDLFVPNELKTNK
                     NTIDLTFAGNIGKAQNLETILKAASAIEQIPDLAKRVHFHFVGDGTELLNMQKLACEL
                     ELENTSFYGRRPLEEMPDFYTKSDAMLVSLIGDSIISRTLPGKVQSYMAAGKPIIGAI
                     SGDTQRVVKEAKCGFISPEGNVDQLVRNIRKFCLLSVEEREKLGRQARCYYEEQFSKE
                     WFMTYLENHLKEGFLS"
     misc_feature    6335..6868
                     /gene="wciJ"
                     /locus_tag="SPC12B_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 3.8e-16"
     gene            6940..8109
                     /gene="wcxB"
                     /locus_tag="SPC12B_0010"
     CDS             6940..8109
                     /gene="wcxB"
                     /locus_tag="SPC12B_0010"
                     /note="member of homology group 55"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33251.1"
                     /db_xref="GOA:Q4K1X9"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X9"
                     /translation="MKVLMINSVCGIRSTGRICTDLATALTEEGYEVKIAYGREYVPK
                     QFQQYAVKIGTKSDIRFHAIRSRLFDESGFGSRQATVNFIKWMKEFDPDIIHLHNLHG
                     YYINVELLFDYLRICGKKIIWTLHDCWAFTGHSAYFDCLECESKGVCDHPSQKNDYPK
                     SFVNFSKRNYQRKKKCFTHIPNLTIVTPSQWLANLVRQSFLKEYPVKVIHNGIDTTVF
                     QPRLIAAQKLRKRHHLEGKQVLLGVAAIWDNRKGFSDMLALANDLTDNQRIVLIGLKD
                     RQLKELPKGIIGLTETNSPEELVAWYTLADVFLNPTYQDNYPTTNLEAISCGTPVISY
                     PTGGSVESAKLYGLVCQDRNVASILSSLEKVSQLSKTEKLDFSIASFIKQMKYLY"
     misc_feature    7612..8094
                     /gene="wcxB"
                     /locus_tag="SPC12B_0010"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 4.2e-12"
     gene            8147..9358
                     /gene="wzy"
                     /locus_tag="SPC12B_0011"
     CDS             8147..9358
                     /gene="wzy"
                     /locus_tag="SPC12B_0011"
                     /note="member of homology group 71"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33252.1"
                     /db_xref="InterPro:IPR007016"
                     /db_xref="UniProtKB/TrEMBL:Q4K1V9"
                     /translation="MMKRIYYHLLAIWAWTLPNSYAFIDSLKVFFPNISLQIAGSLLA
                     VVSIGIFITRIYYTRYEVFISLLVCISILIFYSTRFFYSTNVELYQSFFNSFLIRPVP
                     AILVAMLLAKNNHIKGFIKWSEPMMLFYTLTSFLAALSPRNSIITYQSLSYYAMTAYM
                     INVFNIIYKEKILEEQLTYFRFSAWNFIRYFLLLIQAFNALSGGGRGAFILLIIFTGI
                     LLIRTAMKFKFLFSFIGGLSAIALVVFFTKGLDLTWLLNMDGGERLLNFFGRPEHIST
                     DNRLLIYDTVWSAIQEKPFLGWGVGSTFLKFNGYSHNIVLDLLHDMGSFGLLIILSAF
                     FASSVILYKLRKIDWKVNLFILMFLEVYVHMSFSGSYLADGRLWFLVIFTYCYYRWKV
                     QEKDEVSNFII"
     misc_feature    8963..9130
                     /gene="wzy"
                     /locus_tag="SPC12B_0011"
                     /note="HMMPfam hit to PF04932, O-Antigen Polymerase, score
                     9.9e-08"
     gene            9333..10409
                     /gene="wcxD"
                     /locus_tag="SPC12B_0012"
     CDS             9333..10409
                     /gene="wcxD"
                     /locus_tag="SPC12B_0012"
                     /note="member of homology group 72"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33253.1"
                     /db_xref="GOA:Q4K1V8"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1V8"
                     /translation="MKLAILLSDISKIGGVQRVTTALVNELCQNIDVTIISIFSENEL
                     PAFGLSDRVQVSYLLKEHVNLKKNFFKVSGALRKVLKKQQFDVVLSSGTGLVSFLWFA
                     SLGIPTRLLAWEHQCFYFGRSFGLEWLGRKLACRFAESIVVLTKKDEGFYKENRPKAH
                     IEQIYNILDMDSQTAKCQLSSKKIISVGSLVRQKGFDLALEVASQIQLSYPDWQWDIY
                     GDGPDREKLEEKVREYQLEGFINLKGLVQNVRELYPDYSIYALTSRYEGLSMVLLEAK
                     NCQMPAISFDCNCGPSDIISDGRNGFLIDCFDVNIYAKTLSKLMTSLELREQVAKSSV
                     IPAEELSTTYILDKWNNLLKIERR"
     misc_feature    9834..10340
                     /gene="wcxD"
                     /locus_tag="SPC12B_0012"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.2e-33"
     gene            10411..11589
                     /gene="wcxE"
                     /locus_tag="SPC12B_0013"
     CDS             10411..11589
                     /gene="wcxE"
                     /locus_tag="SPC12B_0013"
                     /note="member of homology group 73"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33254.1"
                     /db_xref="GOA:Q4K1X6"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X6"
                     /translation="MKIVHVEDFFHPDAGYQINVLPKYLAKFGHEQVIITSEMDKIPD
                     NLTQFFGRENIEERDRSYEEKHHVKIIRLPLHGFVSGRAIFSGKLISAIKGLSPEVLY
                     IHGNDTLTGIRLLLARKKLNCRIVTDSHMLEMASRNPFNNYFRRFYKTLITPILIKEQ
                     IPIIRTQDDNYVEKHLGIPLSQAPWISYGSDTAFFHADSQIKEDFRSQYQIASDALIC
                     VYAGKLDEHKGGMFLAESLSKKLNTEQPIVFIIVGNTNGEYGEAVEKSFSQSENQILR
                     FPTQKYQKLAQFFQVADFALFPKQCSLSFYDAQACGLPVLLEDNNINLDRTSHYNGWT
                     FKANSKLSLRDSLKMIASLDKEKRQEYSQNALHYILEHYNYEDKAREYEKILIGERTK
                     "
     misc_feature    11014..11514
                     /gene="wcxE"
                     /locus_tag="SPC12B_0013"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.00013"
     gene            11622..12818
                     /gene="wcxF"
                     /locus_tag="SPC12B_0014"
     CDS             11622..12818
                     /gene="wcxF"
                     /locus_tag="SPC12B_0014"
                     /note="member of homology group 74"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33255.1"
                     /db_xref="GOA:Q4K1X5"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X5"
                     /translation="MDLMKICIVSVGVGGLPIPAVKGGAVENLIDNYLSYNEKYNHDE
                     ITVVSCDHKEAREASKKYKYAQFVYIDIHSLKYKINKTIRYAINKYSPFFVGNAYISQ
                     LPDLSGFDTVLIENRPEYGYYIRKKFKGNLVLHLHNDLLMDNEYSVDYSVYDKIITIS
                     DYIRDRSEVVTSGVPIQTVYNGIDTELFLQNFSEIDLSDLKNQLEILSDDFVIVFFGR
                     INKNKGIKELLEAFLLLPKNLNIKLLAVGSSIFGQTELDTFTTELRQLAKQASDKVVF
                     TGYVNYKDIPKYHHIADCIVVPSIWEEPAGLTVCEALISGKYVITTDAGGIPEIVAGS
                     EALVVANDECIVEHLKTALLSVYQKGKCSSVITSNRDRGAYFSIEKYGRDLRKELTQN
                     ERIINI"
     misc_feature    11622..11696
                     /gene="wcxF"
                     /locus_tag="SPC12B_0014"
                     /note="Signal peptide predicted for SPC0588 by SignalP 2.0
                     HMM (Signal peptide probability 0.653) with cleavage site
                     probability 0.406 between residues 25 and 26"
     misc_feature    12210..12737
                     /gene="wcxF"
                     /locus_tag="SPC12B_0014"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.3e-28"
     gene            12815..14359
                     /gene="wzx"
                     /locus_tag="SPC12B_0015"
     CDS             12815..14359
                     /gene="wzx"
                     /locus_tag="SPC12B_0015"
                     /note="member of homology group 56"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33256.1"
                     /db_xref="GOA:Q4K1X4"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X4"
                     /translation="MSRVKNSFFNILAGIVGTIISSVLAFIVRTVFIRVLGETYLGFN
                     GLYTNILTVLSLAELGIGSSIAYLMYKPLAEKDGDKLAQVVQFYKKIYRVIGIIILIL
                     GLCLVPFLPVIVNLKNAEDLNYTALYLLYLADTVSTYLFFAYKRGVLVADQKVYVANI
                     FDIIITTILSIFQIITLMIWKDFYLYIILKIAKNLTLNLVISLKVDKMYPSIHKFKEI
                     APLPKMERRLVWKNVYATSVRQIFNELMNSTDSIVISIVLGIVMVGKYSNYAYILSIV
                     YIFFGGIFNPIQASIGNLSLLASIEKKNEIFNRLRFINFFFLSFCSSCLLVLVNPFIT
                     IWIGENYTLSFTGVIAIVGMLFVRQTGNCTTIFRLGEGYFRDYHFSPLIAGILNLVVS
                     VILVNYIGIAGVFVGTMLGFGFQFILVDTIVTYKKVLSRPLSEFYLRWLQTILLTVGL
                     CIASYYLSRLVRVNSIYDLILLFVVVIGFNFFALCFIYWRNDDFQYFIQLVKNFMKNL
                     EEKNHD"
     misc_feature    12815..12889
                     /gene="wzx"
                     /locus_tag="SPC12B_0015"
                     /note="Signal peptide predicted for SPC0589 by SignalP 2.0
                     HMM (Signal peptide probability 0.820) with cleavage site
                     probability 0.397 between residues 25 and 26"
     gene            14352..15575
                     /gene="mnaB"
                     /locus_tag="SPC12B_0016"
     CDS             14352..15575
                     /gene="mnaB"
                     /locus_tag="SPC12B_0016"
                     /note="member of homology group 75"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmannosamine dehydrogenase MnaB"
                     /protein_id="CAI33257.1"
                     /db_xref="GOA:Q4K1X3"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR014028"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X3"
                     /translation="MINVIGLGYIGLPTILMLATNGVKVVGTDYNQDLVRTLNEGQTT
                     FKEDGLDELFHKAVESGVDFTTEYQQTDTYIISVPTPYDSFSKKIDPSYVIEATKTVL
                     DNCNKGAVIIIESTVSPGTVDKFIRPVVEEKGFVIGSDIHLVHAPERIIPGNMVYELV
                     NNNRTIGADDLEIGYKVKELYASFCKGDIVVTDIRTAEMTKVVENTFRAVNIAFANEL
                     AQICSYDNMNVYEIIRICNMHPRVNILQPGPGVGGHCISVDPWFLVGDYPELTNVIEH
                     SMRTNAAMPEFVLNRIYTIMNEHHLTDISRVGLYGLTYKENVDDMRESPTLQLLESMS
                     RHLATPAIKVYDPFIEKDVVANQSHDLDEFLSNVDIVVLLVGHDEILQNMDKLKDKIV
                     LDTRYICHLDGTYRL"
     misc_feature    14355..14909
                     /gene="mnaB"
                     /locus_tag="SPC12B_0016"
                     /note="HMMPfam hit to PF03721, UDP-glucose/GDP-mannose
                     dehydrogenase, score 1.4e-45"
     misc_feature    14931..15191
                     /gene="mnaB"
                     /locus_tag="SPC12B_0016"
                     /note="HMMPfam hit to PF00984, UDP-glucose/GDP-mannose
                     dehydrogenase, score 4.5e-33"
     misc_feature    15273..15536
                     /gene="mnaB"
                     /locus_tag="SPC12B_0016"
                     /note="HMMPfam hit to PF03720, UDP-glucose/GDP-mannose
                     dehydrogenase, score 2.5e-15"
     gene            15604..16701
                     /gene="mnaA"
                     /locus_tag="SPC12B_0017"
     CDS             15604..16701
                     /gene="mnaA"
                     /locus_tag="SPC12B_0017"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33258.1"
                     /db_xref="GOA:Q4K1X2"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X2"
                     /translation="MKKIVVIFGTRPEAIKMCPLVKELRTRENLETLVCVTGQHRQML
                     DQVLDTFRITPDFDLSIMKDKQTLFDVTIGILEGMKTVLESVNPDLILVHGDTSTTFA
                     SSLAAFYLQIPIGHVEAGLRTYDIYSPYPEEFNRQAVGALAQYHFTPTQLSKDNLLRE
                     GKNSEAIFITGNTAIDALQTTIQEDYTHPELNWVGDSKLILITAHRRENIGDPMRHMF
                     RAIRRIIEEHSDIKALYPIHMNPLVRQIAEEELSGCERIKMIDPLEVLDFHNFLSRSY
                     LILTDSGGIQEEAPSLGKPVLVMRDTTERPEGIKAGTLKLVGTDEDNIYRHFKELLEN
                     DLVYQAMSQASNPYGDGTACKKIADILEGEV"
     misc_feature    15667..16689
                     /gene="mnaA"
                     /locus_tag="SPC12B_0017"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 2.5e-174"
     gene            16705..17760
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
     CDS             16705..17760
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="member of homology group 36"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlA"
                     /protein_id="CAI33259.1"
                     /db_xref="GOA:Q4K1X1"
                     /db_xref="InterPro:IPR003869"
                     /db_xref="InterPro:IPR013692"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K1X1"
                     /translation="MSQFTGKTLLITGGTGSFGNAVLNRFLQTDIGEIRIFSRDEKKQ
                     DDMRHEFQVKVPEVAGKIRFYLGDVRDLASVKNAMHGVDYVFHAAALKQVPSCEFFPV
                     EAVKTNILGTENVLTAAIEAGVKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAKSRTV
                     NPEHTKICVTRYGNVLCSRGSVVPLWIEQIKQGNALTITEPSMTRFVMTLEEAVDLVL
                     FAFEEGKSGDILVQKAPACTIEVLAKAVSEIFASEQDIKIIGIRHGEKKYETLLTNEE
                     CANAIDLGDFYRVPSDNRNLNYDKYFKDGSTNRNLLTEFNSNNTDLMDVEQVKRKLLE
                     LDEIQTAIRDMVADEEM"
     misc_feature    16726..17580
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.0018"
     misc_feature    16729..17400
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 8.3e-09"
     misc_feature    16729..17577
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 1.1e-162"
     misc_feature    16732..17367
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 8.4e-09"
     misc_feature    17578..17721
                     /gene="fnlA"
                     /locus_tag="SPC12B_0018"
                     /note="HMMPfam hit to PF08485, Polysaccharide biosynthesis
                     protein C, score 2e-23"
     gene            17860..19089
                     /gene="fnlB"
                     /locus_tag="SPC12B_0019"
     CDS             17860..19089
                     /gene="fnlB"
                     /locus_tag="SPC12B_0019"
                     /note="member of homology group 37"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlB"
                     /protein_id="CAI33260.1"
                     /db_xref="GOA:Q4K1V1"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K1V1"
                     /translation="MIKNILITGAKGFVGKNLICTLEALKDGRDRTRPNLEIGEIFQY
                     DRDTDPILLDEYCKKADFVFHLAGVNRPQNPDEFMEGNYGFSSRLLEILEKYENTCPV
                     LLSSSTQASLEGRFSNSIYGQSKLAGEELFFEYGKKTGAPVLVYRFPNLYGKWCRPNY
                     NSAVATFCHNLAHDLPIQVNDPSVELELLYIDDLIQECLTALEGNPHRCNLDGLQILP
                     SPSGNYCYVPTTHRATLGEIVSLLETFKKQPNSLVMPEIPQGSFKKKLYSTYLSYLPV
                     DKFRFPLKMNIDERGSFTELLKTENTGQFSVNISKPGITKGQHWHHSKWEFFMVVSGR
                     ALIQERRIGLDENGQEYPILNFEVSGDKIEAIHMIPGYAHNIINLSDTENLITVMWAN
                     ESFDPRHPDTFFEQVEK"
     misc_feature    17872..18495
                     /gene="fnlB"
                     /locus_tag="SPC12B_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 6.9e-09"
     gene            19090..20274
                     /gene="fnlC"
                     /locus_tag="SPC12B_0020"
     CDS             19090..20274
                     /gene="fnlC"
                     /locus_tag="SPC12B_0020"
                     /note="member of homology group 38"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-L-fucosamine FnlC"
                     /protein_id="CAI33261.1"
                     /db_xref="GOA:Q4K1W9"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K1W9"
                     /translation="MKIKTDYSDIHFKDNGKLKLLIIVGTRPEIIRLSSVITKCRKYF
                     DVILAHTGQNYDYNLNGIFFDNLGLDTPDVYMDAVGDDLGATVGNIINTSYKLMNQIK
                     PDALLILGDTNSCLSAIAAKRLHIPIFHMEAGNRCKDECLPEETNRRIVDIISDVNLA
                     YSEHARKYLHECGLPKERTYVTGSPMAEVLHKNLSAIESSDIHERLGLKKGGYILLSA
                     HREENIDTDKNFISLFTAINQLAEKYNMPILYSCHPRSKKRLQESGFKLDKRVIQHEP
                     LGFHDYNCLQMNAFVVVSDSGTLPEESSFFTSQGYPFPAVCIRTSTERPESLDKAGFI
                     LAGIDENSLLQAVETAVSLAEDEDFGLPVPDYVEENVSTKVVKIIQSYTGIVDKIVWR
                     KS"
     misc_feature    19201..20229
                     /gene="fnlC"
                     /locus_tag="SPC12B_0020"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 4.8e-105"
     gene            complement(20469..20570)
                     /gene="tnp"
                     /locus_tag="SPC12B_0021"
                     /pseudo
     CDS             complement(20469..20570)
                     /gene="tnp"
                     /locus_tag="SPC12B_0021"
                     /note="Lone member of homology group 0227"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1167 transposase (fragment)"
                     /db_xref="PSEUDO:CAI33262.1"
     gene            complement(20637..21582)
                     /gene="tnp"
                     /locus_tag="SPC12B_0022"
                     /pseudo
     CDS             complement(join(20637..20858,20869..21582))
                     /gene="tnp"
                     /locus_tag="SPC12B_0022"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     gene            21679..21864
                     /gene="tnp"
                     /locus_tag="SPC12B_0023"
                     /pseudo
     CDS             21679..21864
                     /gene="tnp"
                     /locus_tag="SPC12B_0023"
                     /note="Lone member of homology group 0228"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            complement(21974..22574)
                     /gene="tnp"
                     /locus_tag="SPC12B_0024"
                     /pseudo
     CDS             complement(join(21974..22324,22305..22574))
                     /gene="tnp"
                     /locus_tag="SPC12B_0024"
                     /note="member of homology group 31"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1671 transposase"
     misc_feature    complement(order(22305..22309,21983..22324))
                     /gene="tnp"
                     /locus_tag="SPC12B_0024"
                     /note="HMMPfam hit to PF05717, IS66 Orf2 like protein,
                     score 4.2e-56"
                     /pseudo
     gene            order(22641..22835,22837..22959,22976..23365)
                     /gene="tnp"
                     /locus_tag="SPC12B_0025"
                     /pseudo
     CDS             join(22641..22835,22837..22959,22976..23365)
                     /gene="tnp"
                     /locus_tag="SPC12B_0025"
                     /note="member of homology group 19"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1381 transposase"
     misc_feature    order(22888..22959,22976..23353)
                     /gene="tnp"
                     /locus_tag="SPC12B_0025"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 4.7e-11"
                     /pseudo
     gene            23626..>23673
                     /gene="aliA"
                     /locus_tag="SPC12B_0026"
     CDS             23626..>23673
                     /gene="aliA"
                     /locus_tag="SPC12B_0026"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33267.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K2C2"
                     /translation="MMKSSRLLALAGVTLL"
BASE COUNT     7598 a   3678 c   4769 g   7628 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcata taaaaacaag
      181 ggaggactgt ataaaaagca gaaatccttt gttttttata accaaggttt ataaactttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaaga agatgaacat
      301 aaagaagcgt gtccttagtg caggcctgac ttttgcatct gctttgcttt tagctacttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac
      421 atttaactat ctattagact attacgctga taatatagtc aattgaaaca agaacaagac
      481 aaaagagcct cgtaaaaggt attgcaactt ggtaatacct ttttgaggtt ctttttgata
      541 tgagcccatg ttttctcaat aggattgtac tcaggtgaat agggaggaag aggtaaaagt
      601 ttatgaccaa actcttcgca taaaagttct agcttaccca ttctatggaa tcttgcatta
      661 tccataataa taaccgatgg tgtggttaat gttggtaaga gaaatttctg aaaccatact
      721 tcaaaaaagt cgttcgtcat cgtctcttcg taagtcattg gagcgattaa ttcaccattt
      781 gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt
      841 aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttca
      901 tcaatctaaa caggtgctag gtgctttaaa ctattaaaat tcttaagaaa taaggctact
      961 ttttctgggt cttgttcata attagattga aactagagta gtacaccttt gcttctaaaa
     1021 cattgttaga aatcgattta actgtcctga ttgatttatc ctattcttgt ttcaatctac
     1081 tatatttttg tttcgcggga agtctactta agatacttaa agatgcagat agtaaaaaag
     1141 atgtagacat taccgtaaaa aagtgatata atcgtatgat gttcaaggta taggtgttaa
     1201 tcatgagtag acgttttaaa aaatcacgtt cacagaaagt gaagcgaagt gttaatatcg
     1261 ttttgctgac tatttattta ttgttaattt gttttttatt gttcttaatc tttaagtaca
     1321 atatccttgc ttttagatat cttaatctag tggtaactgc gttagtccta ctagttgcct
     1381 tggtagggct actcttgatt atctataaaa aagctgaaaa gtttactatt tttctgttgc
     1441 tgttctctat ccttgtcagc tctgtgtcgc tctttgcagt acagcagttt gttggactga
     1501 ccaatcgttt aaatgcgact tctaattact cagaatattc aatcagtgtc gctgttttag
     1561 cagatagtga tatcgaaaat gttacgcaac tgacgagtgt gacagcaccg actgggactg
     1621 ataatgaaaa tattcaaaaa ctactagctg atattaagtc aagtcagaat accgatttga
     1681 cggtcgacca gagttcgtct tacttggcag cttacaagag tttgattgca ggggagacta
     1741 aggccattgt cttaaatagt gtctttgaaa atatcatcga gtcagagtat ccagactacg
     1801 aatcgaagat aaagaagatt tataccaagg gattcactaa aaaagtagaa gctcctaaga
     1861 cgtctaagaa tcagtctttc aatatctatg ttagtggaat tgacacctat ggtcctatta
     1921 gttcggtgtc gcgatcagat gtcaatatcc tgatgactgt caatcgagat accaagaaaa
     1981 tcctcttgac cacaacgccg cgtgatgcct atgtaccaat cgcagatggt ggaaataatc
     2041 aaaaggataa attgactcat gctggtatat atggggttga ttcatccatt cataccctag
     2101 agaaccttta tggtgtagat attaattatt atgttcgttt gaattttacc tcatttttga
     2161 aattgattga cttattggga ggggtagatg ttcataatga tcaagagttt tcagctctac
     2221 atgggaagtt ccatttccca gtagggaatg tccatctaga ctctgagcag gctctaggtt
     2281 ttgtacgtga acgctactca ctagccgatg gagaccgtga ccgtggtcgc aaccaacaaa
     2341 aggtgattgt ggctatcctt caaaaattaa cgtcaaccga agcactgaaa aattatagta
     2401 cgatcattaa tagcttgcaa gattccatcc aaacaaatgt gccacttgag actatgataa
     2461 atttggtcaa tgctcagtta gaaagtggag ggaattataa agtaaattct caagatttaa
     2521 aaggtacagg tcggacggat cttccttctt atgcaatgcc agacagtaac ctctatgtga
     2581 tggaaataga tgatagtagt ttagctgtag ttaaagcagc tatacaggat gtgatggagg
     2641 gtagatgaga tgatagacat ccattcgcat atcgtttttg atgtagatga cggtcccaag
     2701 tcaagagagg aaagcaaggc tctcttggta gaagcctaca gacagggggt gcgaaccatt
     2761 gtctctacct ctcaccgtcg caagggtatg tttgaaactc cggaagagaa gatagcagaa
     2821 aactttcttc aggttcggga aatagctaag gaagtggcga gtgatttagt catcgcttac
     2881 ggggctgaaa tttactacac accagatgtt ctggataagc tagaaaaaaa gcggattccg
     2941 accctcaatg atagtcgtta tgccttgata gagtttagta tgaacactcc ttatcgcgat
     3001 attcatagcg ccttgagcaa gatcttgatg ttgggaatta ctccagtcat tgcccacatt
     3061 gagcgctatg atgctcttga aaataatgaa aaacgcgttc gagaattgat cgatatgggc
     3121 tgttacacgc aagtaaatag ttcacatgtc ctcaaatcca aactttttgg cgaacgttat
     3181 aaattcatga aaaaaagagc tcagtatttt ttagagcagg atttggtcca tgtcattgca
     3241 agtgatatgc acaatctaga cggcagacct cctcatatgg cagaagcata tgaccttgtt
     3301 acccaaaaat acggagaagc gaaggctcag gaacttttta tagacaatcc tcgaaaaatt
     3361 gtaatggatc aactaattta ggagaaatga tgaaagaaca aaacacgata gaaatcgatg
     3421 tatttcaatt atttaaaacc ttgtggaaac gcaagctaat gattttatta gtggcacttg
     3481 tgacaggtgc gggggctttt gcatatagcg cttttattgt taagccagaa tatacgagta
     3541 ccacgcgaat ttacgtagtg aatcgcgatc aaggagacaa gtcggggctg acaaatcagg
     3601 atttgcaggc aggatcttat ctggtaaaag actaccgtga gattatcctt tcgcagaatg
     3661 tattggaaaa agtagcgaca aatttgaagt tggatatacc agccaaaacg ttagctagaa
     3721 aagttcaagt gactgtacca gttgacactc gtatcgtctc aatctctgtc aaggataaac
     3781 agccagagga agccagtcgt atcgctaatt ctctacgaga agttgctgca gaaaagatca
     3841 tcgctgtaac gcgagtatct gatgtaacga cacttgaaga agcgcgacca gctacgactc
     3901 cctcttctcc aaatgttgga cgcaattcct tgtttggttt ttttggagga gcagtcgtaa
     3961 cagtaattgc tgttcttttg attgagttgt tcgacatccg tgtgaaacgt cctgaagatg
     4021 tcgaagatgt actgcaaatt ccacttttag gggtcgttcc agatttggac aaaatgaaat
     4081 aggaggaagt tatgccaaca ttagaaatct cacaggcaaa attggatttt gtaaaaaagg
     4141 cagaggaaaa ttataacgct ttgtgcacga acctacagtt aagtggagat gatttgaaag
     4201 tattttctat cacttctgtg aaacaaggag aaggaaaatc aacgacttcc accaatattg
     4261 cttgggcttt tgcgcgtgca ggttacaaaa cgctgctgat tgatggagat attcgcaatt
     4321 ctgttatgtt aggtgtcttt aaagcaagag ataagattac aggcctgaca gaatttttat
     4381 caggaactac agacctatca caagggcttt gtgataccaa tatcgaaaat ctctttgtaa
     4441 ttcaggctgg ctctgtgtca ccgaatccga cagctcttct tcaaagtaag aatttcagta
     4501 caatgcttga aaccttgcgt aaatattttg actatatcat tgtagatact gctcctgtcg
     4561 gtgtcgtgat tgatgcggct attattacgc aaaaatgcga tgcttctatt ttagtgacga
     4621 aggcaggtga aataaatcga cgggatattc aaaaagcaaa agaacagttg gaacacacag
     4681 ggaagccgtt tttgggagtt gtgttgaata aattcgatac ttcagtagac aaatacggtt
     4741 cttatggaaa ttacggaaaa aaataagtcg ttaagtattt gtgtaaggac atttttagaa
     4801 ctacaatcaa aatctttgga attgctggct tcaaatcata ttgatttgaa atgaaacttg
     4861 caaaagagtt tttaaggtga gtttcttaat ttgtgactga aatcaatctt ctacttccat
     4921 accttggaaa aatagggtaa acgagaaatg ttttttccat aataaagttt tgatatggct
     4981 agtagagtag taatataatg aattgtaatc attagtgttc ataccaagaa atatcaagta
     5041 cctatttttg gaaattataa atgttagata gtgtttaaat ttttacggag agattgtttt
     5101 gagaggtaat ttatgtatag ggaaataaaa cgattaggtg atattttact ttctttcata
     5161 ggaataatag tactgtttcc agtgtttatt ataattgcaa tcgcaataaa gcttgattca
     5221 aaaggtccag taatatttaa gcaaaagcga tttggacttc ataagaaatc gttctatgtc
     5281 ttgaagtttc gaactatgaa ggttgaatcg ccaaaatatg tggcgactcg agacttagat
     5341 aaaccagaac agtggattac caaagtagga gcttgtttgc ggaaaacatc tttagatgaa
     5401 ctgcctcaac tgtggaacat tcttgttggt gatatgagtg ttgtaggacc taggcctgta
     5461 gctataaatg aacttgattt gataaaagaa agagaacagt atggtgccaa tgatatctta
     5521 ccaggattaa ctggatgggc acaaattaat ggacgtgata atttgtcaac agagatgaag
     5581 gcagagatag atggttatta tgtaaaacat atgtcgttaa gaatggatct tagatgtatc
     5641 cttagaacaa tcccctacgt attaaaacgt aagggaattg tggagggtag tggtaagaaa
     5701 gagttggatt gatgcaatga aaattctatt tgtttgtcaa cattataagc cagaaccttt
     5761 tagattgtca gatatttgtg aggatctagt tcaaagaggg cacgaggtgg ctgttttgac
     5821 agggattcct aactatcccg agggggaaat atatgctgat tatcgtaaga gaaaaaaaag
     5881 aagagagact ataaatggtg ttgctatttt tcgttcatac accattgcta ggaggcaaaa
     5941 tactttatac cgtatattga attattttag ttttgctctt tcttctacga taggtgttat
     6001 atttgggcgt tataaagcga aagatggctc agattttgat tgtgtctttg ttaatcaact
     6061 atctccagtt atgatggctt gggctggtat agcttataag aacaagtaca ataaacctat
     6121 gtttttgtat tgcatggatg tttggccgga tagtttaatt gtaggtgggg tgaaggaaaa
     6181 tggattgatt tacaagatat ttgaatttgt ttcaaaaaaa gtatatcaag ccagcgatta
     6241 tatatttgtt actagtctat cttttaaaga ttattttgta aaaaaattta atattcctct
     6301 ccacaaaatt acttacttac cacaatatgc agaggattta tttgtaccaa atgaattaaa
     6361 aacgaacaaa aatactattg acttaacttt tgctggaaat attggaaaag ctcagaattt
     6421 agagactatt ttgaaagcag ccagtgcaat agaacagatt cccgatttag caaagagagt
     6481 tcattttcat tttgttggag atggtacgga actattaaac atgcaaaaat tagcatgtga
     6541 actagaatta gagaacactt cattttatgg tagacgtcca ttagaagaga tgccggattt
     6601 ttatacaaaa tcagatgcga tgctagtttc tttaataggc gactctataa tttctcgcac
     6661 cttaccaggt aaggtacaat cttatatggc ggcaggaaaa ccaattatag gagcgatttc
     6721 aggagatact cagagagttg taaaagaagc aaaatgtggc ttcataagtc cggaagggaa
     6781 tgttgatcag ttagtgagaa atattcgtaa gttctgtttg ctttctgtag aggaaagaga
     6841 gaaactagga aggcaagctc gttgttatta tgaagaacag ttttcgaaag agtggtttat
     6901 gacatactta gaaaatcatt taaaagaggg gtttctatca tgaaggtttt aatgattaat
     6961 tccgtttgtg gtattaggag cactgggaga atttgtacgg atctcgcaac tgctttgaca
     7021 gaagaaggat atgaggttaa aatcgcctat ggtcgtgagt atgttccgaa acaatttcaa
     7081 cagtatgcag tgaaaattgg tacaaagtct gatattcgtt ttcatgcgat tcgttctcga
     7141 ttatttgacg aatctggctt tggaagtaga caggcaactg ttaattttat taaatggatg
     7201 aaagagtttg atcctgatat tattcatctc cataaccttc atgggtatta tatcaatgtt
     7261 gaactgttat ttgattatct ccgaatatgc ggtaaaaaga ttatatggac tttgcatgat
     7321 tgttgggcat ttacaggaca ctcggcttat tttgattgtt tggaatgtga gtcaaaggga
     7381 gtttgtgacc atccatctca gaaaaatgat tatcccaagt cgttcgtgaa tttttcaaag
     7441 cgaaattatc aaagaaagaa aaaatgtttt actcatattc ctaatctcac tattgttact
     7501 ccgtctcaat ggctagctaa tttagtaaga cagtcatttt taaaagaata tccagtgaaa
     7561 gtaattcata atggtattga tactactgtc tttcaaccga ggctaatagc cgctcaaaaa
     7621 ttgagaaaaa gacaccatct tgaaggaaag caggtactgc ttggtgtggc tgctatctgg
     7681 gataatagaa agggattttc tgatatgtta gcgctcgcga atgatctaac tgataatcag
     7741 agaatagttt tgatagggtt aaaagatagg caactcaaag aactacccaa agggatcatt
     7801 gggttaacag aaactaatag cccagaagag ttggtagcat ggtatacact agcggatgta
     7861 tttctaaatc ctacttatca agataattac ccgacaacta atttagaagc tatttcttgt
     7921 gggacaccag ttatcagcta tccgacaggt ggtagtgtag aaagtgctaa actttatggt
     7981 ctcgtttgtc aggatagaaa cgtagcttct attttatctt cgttagaaaa agtctctcag
     8041 ctatctaaaa cagaaaaatt ggatttttca attgcaagtt ttattaaaca aatgaaatat
     8101 ttatattaga acttgaatta taggaaaatg aggaatttgc attaaaatga tgaaaagaat
     8161 ttattatcac cttttggcta tttgggcttg gactcttcca aattcttatg cttttattga
     8221 ttcgttaaag gtgttttttc cgaatattag cttacaaatt gcaggttctc ttttggctgt
     8281 tgtctcaata ggaattttta tcactagaat atattataca agatatgaag tttttatatc
     8341 tctattggtt tgtatttcta ttttaatttt ttattcaact cgcttttttt attcgactaa
     8401 cgtagagttg tatcagtctt tcttcaattc ctttctgatt cgtccagttc ctgcgatatt
     8461 agtagcgatg ctgttagcta agaataatca tataaaaggt ttcataaaat ggtcagaacc
     8521 tatgatgctt ttctatacat tgacatcatt tttagcagcc ctatctccta gaaacagcat
     8581 tattacttac caatctttat cttattatgc catgacagct tatatgatta atgtgtttaa
     8641 tattatatac aaagagaaaa tattggagga gcaactgacg tatttcagat tctcagcgtg
     8701 gaattttatt agatattttt tacttttgat tcaagctttt aatgcactct caggaggtgg
     8761 gagaggtgcc tttattttat taattatttt tacaggaata ttattaataa gaactgctat
     8821 gaaatttaag ttccttttct catttattgg aggcctgtct gctatagctc tagttgtttt
     8881 ttttacaaaa ggtttggatt tgacatggct cttgaatatg gacggtggag agcgattgtt
     8941 gaacttcttc ggcagacctg aacatatatc tacagataat agactattga tttatgatac
     9001 tgtttggtct gcaatacagg aaaaaccctt tttaggatgg ggagttggtt caactttttt
     9061 aaaatttaat ggatattcac ataatattgt attggattta ttgcatgata tgggaagttt
     9121 tggtttatta attattcttt cggctttctt tgcttcttca gtaatattgt acaaattacg
     9181 taaaatagat tggaaagtga atttatttat tctgatgttt ctagaagtat atgttcacat
     9241 gagtttcagt ggaagctatc ttgcagatgg tagactatgg tttttggtga tctttactta
     9301 ttgttactac aggtggaaag tgcaggaaaa ggatgaagtt agcaatttta ttatctgata
     9361 tttcaaaaat aggaggagtg cagcgtgtca cgacagctct tgttaatgaa ctttgtcaaa
     9421 atatagacgt tacaattatc agcatctttt cggaaaatga gctaccagct tttggacttt
     9481 cagatagagt tcaggtgagc tatcttttga aagaacatgt taatttgaag aagaattttt
     9541 ttaaagttag tggagctttg cgaaaagtgt tgaaaaaaca gcagtttgat gttgttctat
     9601 cgtcaggaac tggtctagta tcctttcttt ggtttgctag tttgggaatt cctaccagac
     9661 ttttggcatg ggaacatcag tgtttttact ttgggagatc gtttggtcta gagtggttgg
     9721 ggcgaaagct agcctgtcgt tttgctgaga gtattgttgt cttgactaaa aaagatgaag
     9781 gattttacaa agagaatcgt cctaaggctc atattgaaca aatctataat atcctagaca
     9841 tggattcaca aacagctaag tgtcagctct cttctaaaaa aattatcagt gttggatctt
     9901 tagtacgaca aaaaggtttt gatctggctc ttgaggtagc tagtcaaata caattaagtt
     9961 atccagattg gcagtgggac atttatggtg atggccccga tagagaaaaa ttagaggaga
    10021 aagtcaggga ataccaatta gaaggcttta taaatttgaa agggcttgtt cagaatgttc
    10081 gggagctcta tcctgactac tctatctacg ccttgacatc acgatatgaa ggattatcaa
    10141 tggtattatt agaagctaaa aactgccaga tgcctgctat ttcatttgat tgtaactgtg
    10201 gaccctctga tattatttca gatggaagaa atggtttttt gattgattgt tttgatgtaa
    10261 atatctatgc aaaaacttta tctaaattaa tgactagttt agagttgcga gaacaagttg
    10321 caaaatcgag tgttattcca gcagaagaat tgtcaacaac ttatatccta gataagtgga
    10381 acaatctatt aaagatagaa agaagataat atgaaaatag tccatgtaga agattttttt
    10441 catccagatg caggttacca gattaatgtt ttaccaaaat atctagcaaa gtttggtcat
    10501 gaacaagtga ttatcacttc agaaatggat aaaatccccg ataatcttac ccaatttttt
    10561 ggacgagaaa atatagaaga gagagataga agttacgaag agaagcatca tgtgaagatt
    10621 attcgcttgc ctcttcatgg atttgtaagc ggacgtgcga ttttttctgg aaagcttatt
    10681 tcggctatta agggtctttc tccagaggta ttgtatattc atgggaatga cactttaaca
    10741 gggattcgtc tccttttagc tcgaaagaaa cttaattgca gaatcgtcac cgatagtcat
    10801 atgcttgaaa tggcatcaag aaatcctttc aacaactact ttaggagatt ttataaaacc
    10861 ttgattactc ccattttgat aaaagaacag ataccaatta ttcggacgca agatgataat
    10921 tatgttgaaa aacacttggg aattccttta tcgcaagctc catggatttc ttatgggtcg
    10981 gatacagcgt tctttcacgc agatagccag attaaggaag attttcgttc tcagtatcaa
    11041 atcgcttcag atgctcttat ttgtgtttac gcaggaaagt tagatgagca taagggtggg
    11101 atgtttttag cagagtctct aagtaaaaag ttaaatacgg agcaaccaat tgttttcatt
    11161 atagtgggta atacaaatgg agagtatgga gaagctgtcg agaaaagttt ctcccaatct
    11221 gaaaaccaaa ttttgcgctt tccgactcaa aaatatcaaa aattagcaca gttttttcag
    11281 gtagcagatt ttgctttatt tcctaaacaa tgtagtttaa gtttttatga tgcacaggcc
    11341 tgtggtttac cagttttatt ggaagataat aatatcaacc tcgatagaac ttctcattat
    11401 aatggttgga cgttcaaggc taacagcaaa ttaagtttga gagattcatt aaaaatgatt
    11461 gcgagtctag ataaagagaa gagacaagag tactctcaga atgcactgca ctatatcctt
    11521 gaacattata attatgaaga taaagcaaga gaatatgaaa agattcttat aggggaacgt
    11581 acgaaatgag atagttaata tttcgttatt ttataggaaa ggtggattta atgaaaattt
    11641 gcattgtttc agtcggagtg ggcggactac cgattccagc tgtaaaaggg ggagcagtag
    11701 aaaatctcat tgataattat ttaagttaca atgagaaata taatcatgat gaaattacgg
    11761 tcgttagttg tgaccataag gaggcgcgtg aggcttcaaa aaaatacaag tatgcccaat
    11821 ttgtctatat agatattcat tcacttaaat ataaaataaa caaaacaata cgttatgcca
    11881 ttaataaata ttcacctttc ttcgtaggga acgcttatat cagtcaattg ccagacttgt
    11941 ctggttttga tacagttttg attgaaaatc gccctgaata cggttattat attcgtaaaa
    12001 agtttaaagg aaatcttgtt ttacatcttc acaatgattt attaatggac aatgagtatt
    12061 ctgtagatta tagcgtttat gataaaatta tcacaatatc tgactatatt agggataggt
    12121 cagaagtagt aacgtcaggt gttccgatac agactgtcta taatggtatt gacacagaac
    12181 tttttttgca gaatttctct gaaattgatt tatcagatct taaaaatcag ttggaaattt
    12241 tgtcggatga ttttgtgatt gttttttttg gacgtatcaa caaaaataaa ggtatcaaag
    12301 aactgcttga agccttcttg ttgctaccaa agaatttgaa tataaaatta ctagctgttg
    12361 gtagttctat atttggtcag acggagttgg atactttcac aacagagcta cggcaattgg
    12421 caaaacaagc atcagataaa gttgttttta caggctatgt taattacaaa gacattccta
    12481 agtatcatca tattgcagat tgcattgttg ttccatctat ttgggaggaa ccagcgggtt
    12541 tgacggtctg tgaagctttg atatcaggga aatatgttat tacaacagat gctggaggga
    12601 taccagagat tgtagctggc agtgaagccc ttgtggtagc aaatgatgag tgtatagttg
    12661 aacacctcaa aacagcccta ttgagtgtct accaaaaagg gaaatgctct tcggttatta
    12721 cttctaatag agatagagga gcctattttt ctattgaaaa atatggaaga gacttacgga
    12781 aagagctcac acaaaatgaa agaatcatta acatatgagt cgtgtaaaaa atagtttttt
    12841 taatatttta gctggaatag ttggtactat catatcgagt gttttagctt tcatagttag
    12901 aacagtgttt atccgagttt tgggagagac ttatctaggt ttcaatggtc tatacaccaa
    12961 tatcttaaca gttttatccc tagctgaatt agggatcgga tcatcaattg cttatttgat
    13021 gtacaaacct ttagcagaaa aagatgggga caaattagct caagtagttc aattctataa
    13081 aaaaatatat cgagtaattg gtatcattat tcttatttta ggtttgtgtc tcgttccttt
    13141 tttaccagtc attgtaaatt taaaaaatgc agaagatttg aactatacag cattgtattt
    13201 gctttattta gcagatacag tttctactta tctattcttt gcatataaaa gaggggtatt
    13261 ggttgctgat caaaaggtct atgttgcgaa tatctttgat ataattataa cgacaatttt
    13321 atctattttc caaattatca ctttgatgat ttggaaagat ttttatctat atattatttt
    13381 aaaaattgct aaaaatctta ctttgaacct agtaattagt ttaaaagtag ataaaatgta
    13441 tccaagtatt cataaattta aagagatagc tccacttcca aaaatggaaa gacgactagt
    13501 ttggaaaaat gtatatgcta cctctgttcg acaaatcttt aacgaattaa tgaattcaac
    13561 agatagtata gttatttcca ttgttttagg aatagttatg gttggtaagt attcgaacta
    13621 tgcttatatt ttatcaatcg tatatatttt ctttggagga atttttaatc cgattcaggc
    13681 ttctattgga aacctatctc tgttagcttc tatagagaaa aaaaatgaaa tcttcaatag
    13741 attacgtttt ataaattttt tctttttatc attttgctca agttgtcttc tagtattggt
    13801 aaatcctttt atcactattt ggattggaga aaattacact ttatcattta caggtgtgat
    13861 tgcaatagtt ggtatgttat tcgttagaca aactggaaat tgtacaacca tttttcgttt
    13921 gggagaagga tattttagag attatcattt ttctccttta atcgcgggca ttttaaattt
    13981 agttgtttca gtaattttag tgaattatat aggtattgca ggtgtttttg ttggaacaat
    14041 gttaggattt ggtttccaat ttatactggt ggatacaatt gttacttata aaaaagtact
    14101 tagtcgtcca ctatcagagt tttatttaag atggttgcag acgatcttat taactgtagg
    14161 tttatgtatt gcgagttact atttatctcg attggttaga gtgaatagta tatatgattt
    14221 gatactgttg tttgtagtgg ttattggatt taattttttt gctttatgtt ttatttattg
    14281 gcgaaatgat gattttcaat attttattca attggttaaa aattttatga aaaatttgga
    14341 ggaaaaaaat catgattaat gtaatcggat taggttatat tggattgcca acaattttaa
    14401 tgttggcaac aaacggcgtg aaagtagttg gaactgacta caatcaggat ttggtgagaa
    14461 ctttaaatga aggtcaaaca acctttaaag aagatggatt ggatgaacta ttccataaag
    14521 cagtggagtc gggtgtggac tttacaaccg aatatcaaca aacggatacc tatattattt
    14581 ccgttccaac accatatgac tccttctcta aaaaaattga tccaagctat gtgattgaag
    14641 ctacgaaaac ggtacttgat aattgcaata aaggagcggt tattattatt gaatcgaccg
    14701 tatcaccagg aacggttgat aaatttattc gacctgttgt agaagaaaaa ggttttgtta
    14761 ttggtagtga tattcatctt gtccatgctc cagaacgtat tattccaggg aatatggtct
    14821 atgaattggt gaataataac cgtacaattg gagctgatga cctagaaatc ggctataaag
    14881 tgaaagagct ttatgcttca ttttgtaagg gcgatattgt tgttacagat attagaactg
    14941 cggagatgac caaggtagta gaaaatacat ttagagctgt aaatattgct ttcgctaacg
    15001 aattagcaca gatctgtagt tatgataata tgaatgttta tgaaattatc cggatctgta
    15061 atatgcaccc acgggtaaat attctacaac ctggacctgg tgttggtggg cattgtattt
    15121 ctgtggatcc ttggttctta gttggagatt atcctgagtt gacaaatgtt attgaacatt
    15181 ctatgcgaac aaatgctgcc atgccagaat ttgtattaaa tcgtatctat accattatga
    15241 acgaacatca tctaacagat attagtcggg ttggtctata tggtcttacc tacaaagaga
    15301 atgtagatga tatgcgtgaa tctccaacgc ttcagttatt agaatctatg agccgccatc
    15361 tggcaacacc tgctattaaa gtatatgatc catttataga aaaagatgtt gtggcgaatc
    15421 agtcacatga tttagatgaa tttttatcta atgttgatat tgttgtactg ttggttggtc
    15481 atgatgagat tttacaaaat atggataaac taaaagataa gatagtgtta gatacacgtt
    15541 atatctgtca tcttgatgga acttacagat tataattagt gataaataaa gtaaggattg
    15601 actatgaaaa aaatagttgt aattttcgga actcgtcccg aagctatcaa gatgtgtccc
    15661 ttggttaaag agctaagaac acgtgagaat cttgaaacat tggtctgtgt tacgggtcaa
    15721 catcgtcaaa tgctggatca agttttggat acttttagga ttacgcctga ttttgattta
    15781 tctattatga aggacaaaca aactctcttt gatgtcacaa ttggcatttt ggaaggcatg
    15841 aagactgtct tagagtcagt taatcctgat ttaatattag ttcatgggga tacgagtaca
    15901 acatttgcca gttcactggc cgccttttat ctacagattc caattggaca tgtagaggct
    15961 ggtttgcgta cttatgatat ttattcacct tatcctgaag aatttaatcg tcaagcagta
    16021 ggtgctttgg ctcagtatca ttttacacca acacaactct caaaagacaa tctcttgaga
    16081 gaaggaaaaa attctgaagc tatatttatc acaggtaaca cagcaattga tgctttacaa
    16141 actacaattc aagaggatta tactcatcct gagttaaatt gggttgggga tagcaaacta
    16201 atattaatta ctgctcatcg tcgtgaaaat attggtgacc cgatgaggca catgtttaga
    16261 gcaatccgac gtatcattga agaacattcg gatataaagg ctctttaccc cattcatatg
    16321 aatcctctag ttcgtcagat tgctgaggaa gaactaagcg gatgtgaacg tatcaaaatg
    16381 atcgatccgt tggaagtatt agattttcat aactttttat cacggagtta tctcatttta
    16441 acagatagtg gtggtatcca agaagaggca cctagtttag gaaaacctgt tttagttatg
    16501 agagatacaa ctgaacgtcc ggagggaatt aaagcaggaa ctttgaagct tgtaggtact
    16561 gatgaggaca atatttatag acattttaaa gaattgttag aaaatgattt agtttatcaa
    16621 gcgatgagcc aagcttcaaa tccgtatgga gatggaacag cttgcaagaa aattgcagac
    16681 atactagaag gagaagtata atatatgtca caatttacag gaaaaactct cctaattaca
    16741 ggaggaacag gttcatttgg taatgctgtc cttaatcgtt ttttacagac tgatattggt
    16801 gaaattcgta ttttttcccg tgatgaaaaa aaacaggatg atatgcgtca tgagtttcag
    16861 gtaaaagtac cagaagtagc tgggaaaatc cgtttttacc ttggagatgt gcgtgactta
    16921 gcttcggtaa aaaatgctat gcatggtgtg gattatgttt ttcatgctgc tgctcttaaa
    16981 caagtacctt cgtgtgaatt tttccctgta gaagcggtaa aaactaacat tttgggaacg
    17041 gagaatgtcc tcactgcggc tatcgaagct ggtgtaaagc aagttatctg tctttctaca
    17101 gataaggcgg cttatcctgt caatgctatg ggaacatcca aggctatgat ggaaaagatt
    17161 gctgttgcta agtccaggac ggtaaatcct gagcatacaa agatatgtgt gactcgctat
    17221 gggaatgttc tgtgtagccg tggatctgtc gttcctcttt ggattgagca aattaagcaa
    17281 ggaaatgctc ttacaattac tgaacctagc atgacacgtt ttgtgatgac attagaagaa
    17341 gcagtagact tggttttatt tgcatttgaa gaagggaaat ctggagatat actagttcag
    17401 aaagcaccag catgtacgat tgaagtgttg gctaaggctg tatcagaaat ttttgcctca
    17461 gaacaagata ttaagattat aggtattaga cacggagaaa aaaagtatga aacactatta
    17521 actaatgaag agtgcgcaaa tgcaattgat ttgggtgatt tttatagagt tcctagtgat
    17581 aatcgtaatc ttaactatga taagtatttc aaagatggta gtacgaatag aaatttgttg
    17641 acagaattca atagtaataa taccgatttg atggatgtag agcaagttaa aagaaagttg
    17701 ctagaattag atgaaataca gacagcaatt cgtgatatgg tagcagatga agagatgtaa
    17761 aatcttttaa gatacattaa aattatcaag gatatataat gtatcatgta ttgtcgagag
    17821 agttgactat taaaacagca tataaaacaa ggagggggca tgattaaaaa tattttaatc
    17881 acaggagcga aaggatttgt aggaaaaaat cttatctgta ctctggaagc tttgaaagat
    17941 ggacgagata ggactcgtcc taatttagag attggagaga tttttcagta tgatcgtgat
    18001 acagatccga ttttattaga tgaatattgt aagaaggccg atttcgtatt ccatttagct
    18061 ggtgtcaatc gtccacagaa tcctgatgaa ttcatggagg gaaattacgg tttttcaagt
    18121 agattattgg agattttaga aaagtatgaa aacacttgtc ctgttctact ctcaagttct
    18181 actcaagcta gtttagaagg ccgattttca aactctatat atggacaatc taagctagca
    18241 ggggaagaac tcttctttga atatggaaag aaaacgggag cacctgtctt agtttaccgt
    18301 ttcccgaatc tttatgggaa gtggtgccgt cctaactaca attctgctgt agcaactttc
    18361 tgtcataatc tagctcacga tttacctatt caagtaaatg atccaagtgt agaattggag
    18421 ttgctgtata ttgatgattt gatacaagag tgtctaactg cattggaagg aaatcctcat
    18481 cgttgtaatc tagatggatt acaaatctta cctagcccat caggaaacta ctgctacgta
    18541 ccaacgactc atcgtgcaac cttaggagag attgtctctc tattagaaac atttaaaaaa
    18601 cagcctaata gtttagttat gcctgaaatt cctcaaggat cgtttaaaaa gaaattgtat
    18661 tctacctacc tatcttattt accagtagat aagtttaggt ttcctctaaa aatgaatata
    18721 gatgaacgag gtagttttac ggaattatta aaaacagaaa atacgggtca attttctgtt
    18781 aatatttcta aacctggcat taccaaaggg caacattggc atcattctaa gtgggaattt
    18841 ttcatggttg tttctggtcg tgctttaata caagagcgta ggatagggct ggatgaaaac
    18901 ggtcaagagt atcctattct gaactttgaa gtgtcgggcg ataagattga agcaatacat
    18961 atgataccgg gctatgcaca taatattatt aatctttctg atacagaaaa tctaattact
    19021 gtcatgtggg ctaatgagtc atttgatcct agacatccag atactttttt tgaacaagtg
    19081 gagaaataaa tgaaaattaa gacagattat agtgatattc attttaaaga taatggcaaa
    19141 cttaagttat tgattattgt gggaacacgt ccagagatta tacgtctaag tagtgttatc
    19201 actaaatgtc gaaagtattt tgatgttatt ttggcacata ctggacaaaa ctatgattac
    19261 aatttaaatg gtattttctt tgataattta gggttagaca ctccggacgt atacatggat
    19321 gctgttggag atgatcttgg tgctactgta gggaatatta ttaatacttc atacaaattg
    19381 atgaatcaaa ttaaaccaga tgctttattg attttagggg atacaaattc ttgtttatca
    19441 gctattgctg ccaagcgttt acatattcca atttttcata tggaggctgg caatcgctgt
    19501 aaagatgagt gcctgccgga agagactaat cgtcggattg ttgatattat ttcagatgtt
    19561 aacttagcat actctgaaca tgcacgtaag tatttacatg agtgtggttt acctaaagag
    19621 cgcacatatg taactggttc tcctatggca gaagtgttac ataaaaattt atctgccatt
    19681 gagtcttcag atatccatga acgtttggga ttgaaaaaag gaggttatat cttactttca
    19741 gctcaccgtg aggaaaatat tgatacagat aaaaatttta tttctctctt tacagcaatt
    19801 aatcaattag ctgaaaagta taatatgcca atcttatatt cttgccatcc tagatcaaag
    19861 aaaaggctac aagagagcgg ttttaaacta gataaacgtg tgattcagca tgagccacta
    19921 ggattccatg actataattg tttacagatg aatgcatttg ttgtagtatc tgattcggga
    19981 actttaccgg aagaaagtag tttctttact agtcaaggtt atccttttcc cgctgtatgt
    20041 attcgtacaa gtacagaacg tcctgagtcc ttagataagg caggatttat tttggcaggc
    20101 attgatgaaa attctcttct tcaagcagtt gaaactgctg ttagcttggc agaagatgag
    20161 gattttggat taccggttcc agattatgtt gaggaaaatg tctctactaa agttgttaag
    20221 ataatacaga gctatacagg gatagtggat aaaatagttt ggaggaaaag ctgaattgta
    20281 tatttttaat aaatcaaaac gagatgatta attcttagta gaacaagagt aaaattgaac
    20341 gtatttgatg gaaatgtctt acttgatagt cgagggatag ccattctatc ggatttttgg
    20401 cttgtttttg cgcttcatgt ttgatagaat aaagggctct ttgtcaactg tagtgggttg
    20461 aagaaaagct aagcttgaga aaggacaaat ttcgtccttt cttttttgat gttcagagcg
    20521 ataaaaatcc gttttttgaa gttttcaaag tttcgaaagt aaccgcccaa taacgaagta
    20581 tattgaaaaa tctccagact agagaactca cggatagttc ctaatctgga gatttcttat
    20641 ttgcactttt cttgtacaac tttagtccat ggtaaataag cctctaaaac ctctttgttt
    20701 acgagagttt cctcgtttgg aagacattct agaagatagg atagatattt ctcactattt
    20761 agttgatgac gtttagctgt ttccaacaag ctcataataa tagctcttgc tttagctcct
    20821 tcaaaacttt gagaaaataa ccaccctcgc ttttttaaac tgagctcagg ctaaaagagt
    20881 ccactggact cttttactcc gtcccataac caatgattta atggcgcgtt cagctagatt
    20941 attggaaagg accagatgtc cgtctttcaa aatagtctta aaggtttctt catacttgag
    21001 gctgtattca attgcccttc ctagttttga acctgctaaa actgactgac gccggcacca
    21061 agcaaagaag tcttccatta ggggctggag atgttcttga cgtttctgta gtcgttcatc
    21121 agctggcaaa gcctcccagt ctctttccaa ggaaaataac tgatcacaat aagctaaacc
    21181 tttagctcct aaggatgatt tatctgcttg cttgggggtc gcttcaaaaa atttccttct
    21241 cacatgcgcc caacatccaa caagttcagc ttcttccagt tgacgataag cttctagcgg
    21301 ttcgcagttt accaagctta gcgtcgcctt gctcctaaac cttggactgc tatcgcatag
    21361 gcagaactag aggactaaag tcctaagtta ctgccgcaac atatcacaat gaacatagcc
    21421 agaataatct cctaggaatt cttgtactac cgaaccactc cgactctgat catgatggta
    21481 cagcgtgatt gcttgattct caactttccc agacaaaaag gtccaatagt aggtcagatg
    21541 gctatgactc tctagaaccc gataagaagt ttcatccgca tgaagtaagg gctgagtcaa
    21601 tagtctctct cgcaagaggt tataaagggg ctttaggaat aggagctttc acaagcttat
    21661 ccagatgatt atcttttatt cgttatggac aatgctatat ggcataaatc aagtacctta
    21721 aagattccga ctaatattgg ctttgcattt attcctccat acacaccaga gatgaacccc
    21781 attgaacaag tgtggaaaga gattcgtaaa cgtggattta aaaataaagc ctttcaaact
    21841 ttggaagatg tcatgaatca actttaagat atcatacaag gactggagaa ggaggtgata
    21901 aagcccatcg ttaatcggag atggactaga atgctttttg aaagcagatg agtataaaaa
    21961 gaaagtcctc atttcaatag aaatcacgac tttctgatgg atttattttt ggagtgatag
    22021 aaaagccctt cataagccag tctacttgtt caggtgtgag agctttgaca tccttttctg
    22081 tactgggcca agtcagtctg ccgttctcaa agcgtttata tagtagccaa aatccttgac
    22141 catcccagta aagggcttta aagcggtctt tacgtccacc acaaaagaga aagacttgac
    22201 cggagaaagg atccaattca aagtgggttt taaccagata agtcagtgaa tcaatgcctt
    22261 gcctcatatc cgttttccca catacgagat agacctgccc taggctagat agatgaattg
    22321 tcatagagca acaccttatc caaaagctgt tctatcattt cgagattgag agattgaaaa
    22381 aaacttactt caagcttgcc aatacgaatt ttaagcagaa tatcatttct ctttttagaa
    22441 tcaaaaggac gagattgtgg aatctctaca ggaacaatag gttgtggcat taaaatatcc
    22501 tccaatagtt ttactttact aatagtatac aggaggagct ccatgaatga tagatacctt
    22561 gttatgacgc gcttactaaa caactaactg atgcacgatt taagcgcctt gttggtgttc
    22621 agcgcacgac ttttgaagag atgttagctg tattaaaaac agcttatcaa cttaaacacg
    22681 caaaaggtgg acgaaaacct aaattaagcc tagaagacct tcttatggcc actcttcaat
    22741 atgtgcgaga atatcgaact tatgaagaaa ttgcggctga ttttggtatc cacgaaagca
    22801 acttaatccg tcggagccaa tgggttgaag taactcttgt tcaaaggtgg tgttacgatt
    22861 tcaagaactc ctctcagttc tgaggacacg gtaatgattg atgcgacgga agtaaaaatc
    22921 aatcgcccta aaaaaacaat tagcgaatta ttctggtaaa aagaaatgcc acgctatgaa
    22981 ggctcaagcg attgtcacaa gtcaagggag aattgtttct ttggatatca ctgtgaacta
    23041 ttgtcgtaat atgaagttgt tcaaaatgag ttgcagaaat atcggacaag ctggaaaaat
    23101 cttggctgac agtggttatc aagggctcat gaagatatat cctcaagcac aaactccacg
    23161 taaatccagc aaactcaatc cgctaacagc taaagataaa gcctataacc atgcgctatc
    23221 taaggataga agcaaggttg agaacatctt tgccaaagta aaaacgttta aaatgttttc
    23281 aacaacctat cgaaatcatc gtaaacgctt cggattacga atgaatttga ttgctggtat
    23341 tatcaatcat gaactaggat tctagttttg caggaagtct attgaaggat cttttgcttt
    23401 agttccttgg tcaaggttga ttattttcac ggagcgcttc cgattgtttt cataaaccat
    23461 ttgcgcatag tcagcagaat aaatcttttt gaaacgtccc tttcctagac attatagaac
    23521 tttcagattc atctgaattt accaaattaa caaaaaaatt ctgaaaattc tgttgacaac
    23581 tttctgaaaa gagtctataa tggagagaaa gttttaaagg agaaaatgat gaaaagttca
    23641 agactacttg cccttgcggg cgtgacatta ttg
//
