LOCUS       CR931671               21887 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 8609/43 (serotype 18a).
ACCESSION   CR931671
VERSION     CR931671.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21887)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 21887)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..21887
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="8609/43"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC18A_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC18A_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI33524.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            294..467
                     /gene="aliB"
                     /locus_tag="SPC18A_0002"
                     /pseudo
     CDS             294..467
                     /gene="aliB"
                     /locus_tag="SPC18A_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
                     /db_xref="PSEUDO:CAI33525.1"
     gene            complement(460..1086)
                     /gene="tnp"
                     /locus_tag="SPC18A_0003"
                     /pseudo
     CDS             complement(460..1086)
                     /gene="tnp"
                     /locus_tag="SPC18A_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1297..2742
                     /gene="wzg"
                     /locus_tag="SPC18A_0004"
     CDS             1297..2742
                     /gene="wzg"
                     /locus_tag="SPC18A_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33527.1"
                     /db_xref="GOA:Q4K198"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K198"
                     /translation="MSRRFKKSRSQKVKRSINIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALFLLVALVGLLLIIYKKAEEFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSEFENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYRSLIAGETKAIVLSSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KMSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTATPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSDLHGKFHFPVGNAHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAIIQKLTST
                     EVLKDYSSILQGLQDSLQTNMPIETMMDLVNTQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1297..1413
                     /gene="wzg"
                     /locus_tag="SPC18A_0004"
                     /note="Signal peptide predicted for SPC0865 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.553 between residues 39 and 40"
     misc_feature    1501..1848
                     /gene="wzg"
                     /locus_tag="SPC18A_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.3e-60"
     misc_feature    2026..2469
                     /gene="wzg"
                     /locus_tag="SPC18A_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 3.8e-69"
     gene            2744..3475
                     /gene="wzh"
                     /locus_tag="SPC18A_0005"
     CDS             2744..3475
                     /gene="wzh"
                     /locus_tag="SPC18A_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33528.1"
                     /db_xref="GOA:Q4K197"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K197"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAEAYRQGVRTIVSTSHRR
                     KGMFETPEEKIATNFIKVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSHHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     misc_feature    2747..3355
                     /gene="wzh"
                     /locus_tag="SPC18A_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 8.7e-40"
     gene            3484..4176
                     /gene="wzd"
                     /locus_tag="SPC18A_0006"
     CDS             3484..4176
                     /gene="wzd"
                     /locus_tag="SPC18A_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33529.1"
                     /db_xref="GOA:Q4K196"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K196"
                     /translation="MKEQNTLEIDGLQLFRALWKRKLVILLVAIITSSVAFTYSTFVI
                     KPEFTSTTRIYVVNRNQEEKPGLTNQDLQAGSYLVKDYREIILSQDVLEEVVSGLKLD
                     LTPKGLANKIEVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPAISPSSPNIKRNTLIGFLAGGIGTSVIVFLLELLDTRVKRPEDIEDTLQMT
                     LLGVVPNLNKLK"
     misc_feature    3502..3918
                     /gene="wzd"
                     /locus_tag="SPC18A_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 6.1e-49"
     misc_feature    4024..4101
                     /gene="wzd"
                     /locus_tag="SPC18A_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4186..4869
                     /gene="wze"
                     /locus_tag="SPC18A_0007"
     CDS             4186..4869
                     /gene="wze"
                     /locus_tag="SPC18A_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33530.1"
                     /db_xref="GOA:Q4K195"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K195"
                     /translation="MPTLEIAQKKLEFIKKAEEHYNALCTNIQLSGDKLKVISVTSVS
                     PGEGKTTTSVNIAWSFARAGYKTLLIDGDTRNSVISGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGAVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGETNKRDVQKAKQQLKQTGKLFLGVVLNKLDISVDKYGVY
                     GFYGNYGKK"
     gene            4885..6252
                     /gene="wchA"
                     /locus_tag="SPC18A_0008"
     CDS             4885..6252
                     /gene="wchA"
                     /locus_tag="SPC18A_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33531.1"
                     /db_xref="GOA:Q4K194"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K194"
                     /translation="MDEKGLKIFLAVLQSIVVILLIYFLSFVRETELERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSVSRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMG
                     IDVTVNLNAFDKNLGRNKQIHEMVGLNVVTFSKNLYKTSHVISKRILDICGATIGLIL
                     FAIASLVLVPLIRKDGGPAIFSQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTM
                     QGGMFKINNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPE
                     QKRRLSFKPGITGLWQVSGRSKITDFDAVVKLDVAYIDNWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    5668..6249
                     /gene="wchA"
                     /locus_tag="SPC18A_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 1.9e-146"
     gene            6283..7455
                     /gene="wchF"
                     /locus_tag="SPC18A_0009"
     CDS             6283..7455
                     /gene="wchF"
                     /locus_tag="SPC18A_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33532.1"
                     /db_xref="GOA:Q4K193"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K193"
                     /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMR
                     ENSAKSGTTEDVFEHNGAICYNVDVPNIGPARAIAYDIAAINRAIEIAKENNGEDPIF
                     YILACRIGPFIHGIKKRIQAIGGALLVNPDGHEWLREKWSLPVRKYWKYSERLMVKHA
                     DLLVCDSKNIEKYIQEDYKQYQPKTTYIAYGTDTTRSILKSSDEKVRSWFKEKNVSEN
                     EYYLVVGRFVPENNYEAMIRGFLASNSKKDFVLITNVEQNKFYNQLLAKTGFDKDPRV
                     KFVGTVYEQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVGE
                     QSAIYWKKDELSQVIEKVEQFDAKMIDELDRQSNQRITDSFTWEKIVTDYEKLFKK"
     gene            7452..8723
                     /gene="wciU"
                     /locus_tag="SPC18A_0010"
     CDS             7452..8723
                     /gene="wciU"
                     /locus_tag="SPC18A_0010"
                     /note="member of homology group 59"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33533.1"
                     /db_xref="GOA:Q4K192"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K192"
                     /translation="MKILHYTLGFQPQRTGGLVKYAEDLMIEQIAQGYQVAALCPGRI
                     KFFSKKIEIIKATSRQFECYELLNSLPIALFGGISDPTAFMTPCDKNVYRTFLEKVQP
                     DIIHIHSFMGLHKEFLEIAKNLNIRVVFTSHDYYGLAPVPHFYFNGVDYSDKNTNLTW
                     NIMSSNALSVKKLRLFQVSFYPTIRKLLKLLGKNPKSKKNLVIRDVIEEQDYSELRYY
                     YNEMFHLIDGYLFNSRLAKKVYEINEIQPANSVVLSITSSSIKHHQRLTTTNNKIRVS
                     YIGSDEEYKGYFDFIDFAGTLEQESYEVVTYGHLPNEECPSFIEQKGYFTKETIDSVY
                     ENIDILIIASKCKETFGLITVEALSYGVNVFVSENVGSKDLLPETHVFKDKEDLLAKI
                     INNQLEKVPLKTMEKHVEEVISYYKQVRSNN"
     misc_feature    8226..8696
                     /gene="wciU"
                     /locus_tag="SPC18A_0010"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.0002"
     gene            8729..9793
                     /gene="wciV"
                     /locus_tag="SPC18A_0011"
     CDS             8729..9793
                     /gene="wciV"
                     /locus_tag="SPC18A_0011"
                     /note="member of homology group 91"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33534.1"
                     /db_xref="GOA:Q4K191"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K191"
                     /translation="MIKDMSCPEISVIVPVYNVERYLRQCMDSLINQTYRDFEIILVN
                     DGSTDSSGILCEEWAKKDERIHVVHKKNEGLGFARNTGVEHAKGKYITFVDSDDYVSL
                     DMLQTLYNAVQEYDVEVVYSAGYYRSFSNGEIKKTDVGTKKPQLFEGGDVASELLPNV
                     ISAPPEYPNDGKVGVSAWKVLYKANLFKDKGLLFHSEREFISEDAIFQIDCLKLATSA
                     LVIPDILYYYRENFGSLSMKYKEDRFELDKILYNEQLKRVEGLPNQEILEERIERILI
                     ANIRLCVFQESLHKSSRIHKRLQRIRQICKDPVSKVVLHHYPIHRLPFPKRLICVLAK
                     YNMSLFLLALTLLKYRNRSV"
     misc_feature    8759..9301
                     /gene="wciV"
                     /locus_tag="SPC18A_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 2.2e-45"
     gene            9799..10710
                     /gene="wciW"
                     /locus_tag="SPC18A_0012"
     CDS             9799..10710
                     /gene="wciW"
                     /locus_tag="SPC18A_0012"
                     /note="member of homology group 92"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33535.1"
                     /db_xref="GOA:Q4K190"
                     /db_xref="InterPro:IPR008441"
                     /db_xref="UniProtKB/TrEMBL:Q4K190"
                     /translation="MGMNIEKLKLSLKNRTFFPVVIHALRNRWPLWWIRSKAIREVQL
                     EDRAYRILKKKYGSLISNSFDKAYLSEKVPKQIWICWFQGMENAPDLVKSCYRSLKKQ
                     FPEYVITVISSENIFEYVEIPDILYEKWVNGVIGNAHFSDILRVELLRKFGGIWIDST
                     VYCTGITTIQIIGKNPFFMYKSVSSVEERISSSNWMIASVPNHPFMITMSKLLQSYWS
                     KEVIAIHYYLFHILFTIMIESLPELWQLVPTYTNAAPHIMIDELNNVFSKERYQQLCQ
                     ISDFHKLNYKKNYNDKSESLYSYLLNQ"
     misc_feature    9880..10698
                     /gene="wciW"
                     /locus_tag="SPC18A_0012"
                     /note="HMMPfam hit to PF05704, Capsular polysaccharide
                     synthesis protein, score 6.1e-139"
     gene            10722..12179
                     /gene="wzx"
                     /locus_tag="SPC18A_0013"
     CDS             10722..12179
                     /gene="wzx"
                     /locus_tag="SPC18A_0013"
                     /note="member of homology group 7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33536.1"
                     /db_xref="GOA:Q4K189"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K189"
                     /translation="MPSLKKNIVYNVLYQILAVIVPFITSPYLARVLGAEQIGVYSFT
                     YSIAFYFMILSMLGISNYGNRTIARVRTSREHLNQEFSNIYAVQLTCSLVMTISYLIY
                     ATVFVNSFQIVAYIQVLHVLSYATDVSWFFYGLEEFRITVARNSFVKLLTLISIFTFV
                     KSPNDIYLYTFIMAGGTLLGQLITWPFLLKQVNFVCPSLGKIKKHMKPIIILFFPVLA
                     VSIFSFLDKIMLGMYSSLKETAFYENSDKIISIPKALIQAFGAVMLPRTVHLLSIGDE
                     QKSLEYVDKTMWAVLVITMGCAFGLAGVSATFAPVYWGEEFRASSQIIAGMTPALVFS
                     AFGNVIRTQFLIPRSFDKEYTVSLLYGAVVNILINILLIPKIGAMGAVIGTIVAELVL
                     CCYQTWIARNYLHIREYLINAGILFLIGSVMYMVLILISSILPTSLLTLIIEIIVAAF
                     IYISLLILHIFSSKNRVIIGLRTNFLERTHLFKRK"
     misc_feature    10731..11534
                     /gene="wzx"
                     /locus_tag="SPC18A_0013"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 8.6e-59"
     gene            12182..13453
                     /gene="wzy"
                     /locus_tag="SPC18A_0014"
     CDS             12182..13453
                     /gene="wzy"
                     /locus_tag="SPC18A_0014"
                     /note="member of homology group 93"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33537.1"
                     /db_xref="InterPro:IPR007016"
                     /db_xref="UniProtKB/TrEMBL:Q4K188"
                     /translation="MKFKFKFNPIAILYILLVYLELATDRQHLYPVTYMTKYYIGILI
                     TVLFVLLLVGRGKLIFVNKKLLYLAKILAIPTIVLFLYSVLLDVMNPVEFDGYFSRLS
                     STTIFGLLAIFQAIVVFQFFGQKVVDYTFTAISLSYLTSIIVAFRQGGLSQFILMLTD
                     DSFNGSVLEMHEVAPITALFILYYLYKYFIKENSFSSVFRNILIALIILFLSLKRIVF
                     LSVLIIIPVFLIIYWYDKKVSKLGKERKILSLLNSFSLIFITGIFLYVYSVKSGFIYT
                     FIQEHNINSMARTDLWKGIESTYSFAPIFMGRGIGFVTKWMDNNWMTLNINGLTESTG
                     LHNDILKYYIEIGFVGLFIYFYTLLYRNAKRIFVKIGHKESFIYFVLIMFQMLIWFTD
                     NISTYHNFLWILNLLLFSLTNTDAELETQKL"
     misc_feature    13025..13237
                     /gene="wzy"
                     /locus_tag="SPC18A_0014"
                     /note="HMMPfam hit to PF04932, O-Antigen Polymerase, score
                     1.7e-09"
     gene            13533..14693
                     /gene="wciY"
                     /locus_tag="SPC18A_0015"
     CDS             13533..14693
                     /gene="wciY"
                     /locus_tag="SPC18A_0015"
                     /note="member of homology group 78"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol phosphotransferase"
                     /protein_id="CAI33538.1"
                     /db_xref="GOA:Q4K187"
                     /db_xref="InterPro:IPR007554"
                     /db_xref="UniProtKB/TrEMBL:Q4K187"
                     /translation="MKFYIKNLLKKVFTLPLHLLPIQSNKIIFDNFGGRGFGDNPKYI
                     LEELVSREKNLNLVWVTKDREISIPEGVRVVKYGSYRSFYEWLTARVWVDNIRNSDRP
                     WKRKGQIYLQTWHGSDGVKLIEKSVAGNLKKTYLRMAKYDGKITDGIVSSRHFQTLGM
                     QNNFWLTENVEFLEFGLPRNDDFFKSEKIKTTNIKFRTLFDIDLDELVVLYMPTFRDD
                     GSLNAYNLDYSKLIHVFQNKFRKNVKILVRFHPNVDSNFINLQDTDCINVSTYSNPQD
                     LMMSADVMITDYSSASIDFMLLNRPVFLYLPDYQSYVNDRPLDDNFDKLPFPRAYHNN
                     ELTEIIRDFERSKYDEKVRLYELEDVRFDRGKASVQCANWIEEKIKNNKVID"
     misc_feature    14118..14663
                     /gene="wciY"
                     /locus_tag="SPC18A_0015"
                     /note="HMMPfam hit to PF04464,
                     CDP-Glycerol:Poly(glycerophosphate) gl, score 3.3e-68"
     gene            14735..15127
                     /gene="gct"
                     /locus_tag="SPC18A_0016"
     CDS             14735..15127
                     /gene="gct"
                     /locus_tag="SPC18A_0016"
                     /note="member of homology group 28"
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol-1-phosphate biosynthetic protein
                     Gct"
                     /protein_id="CAI33539.1"
                     /db_xref="GOA:Q4K186"
                     /db_xref="InterPro:IPR004820"
                     /db_xref="InterPro:IPR004821"
                     /db_xref="InterPro:IPR006409"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="UniProtKB/TrEMBL:Q4K186"
                     /translation="MKRIITYGTFDLLHYGHISLLKRAKQLGDYLIVVVSSDEFNLKE
                     KNKVCYFNYEHRKNLVEAIRYVDLVIPETSWEQKKSDVKEYHIDTFVMGDDWKGKFDY
                     LEEEGVEVVYLPRTKEISTTKIKEDLSE"
     misc_feature    14747..15115
                     /gene="gct"
                     /locus_tag="SPC18A_0016"
                     /note="HMMPfam hit to PF01467, Cytidylyltransferase, score
                     3.4e-29"
     gene            15180..15856
                     /gene="HG94"
                     /locus_tag="SPC18A_0017"
                     /pseudo
     CDS             join(15180..15350,15340..15594,15521..15856)
                     /gene="HG94"
                     /locus_tag="SPC18A_0017"
                     /note="member of homology group 94"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein (pseudogene)"
     gene            complement(order(15740..16110,16139..16444))
                     /gene="tnp"
                     /locus_tag="SPC18A_0018"
                     /pseudo
     CDS             complement(join(15740..16066,16063..16110,16139..16444))
                     /gene="tnp"
                     /locus_tag="SPC18A_0018"
                     /note="member of homology group 19; member of homology
                     group 19"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1381 transposase"
     misc_feature    complement(join(15752..16066,16063..16110,16139..16201))
                     /gene="tnp"
                     /locus_tag="SPC18A_0018"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 7.5e-05"
                     /pseudo
     gene            16838..17707
                     /gene="rmlA"
                     /locus_tag="SPC18A_0019"
     CDS             16838..17707
                     /gene="rmlA"
                     /locus_tag="SPC18A_0019"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33542.1"
                     /db_xref="GOA:Q4K185"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K185"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSV
                     ALILGDNIYHGPGLSKMLQKAAGKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLTLAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    16841..17557
                     /gene="rmlA"
                     /locus_tag="SPC18A_0019"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 4.1e-120"
     gene            17708..18301
                     /gene="rmlC"
                     /locus_tag="SPC18A_0020"
     CDS             17708..18301
                     /gene="rmlC"
                     /locus_tag="SPC18A_0020"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33543.1"
                     /db_xref="GOA:Q7BTQ6"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q7BTQ6"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
     misc_feature    17744..18274
                     /gene="rmlC"
                     /locus_tag="SPC18A_0020"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            18314..19363
                     /gene="rmlB"
                     /locus_tag="SPC18A_0021"
     CDS             18314..19363
                     /gene="rmlB"
                     /locus_tag="SPC18A_0021"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33544.1"
                     /db_xref="GOA:Q4K2P4"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K2P4"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPGVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    18329..19285
                     /gene="rmlB"
                     /locus_tag="SPC18A_0021"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.0001"
     misc_feature    18332..19072
                     /gene="rmlB"
                     /locus_tag="SPC18A_0021"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 2.7e-76"
     misc_feature    18335..19147
                     /gene="rmlB"
                     /locus_tag="SPC18A_0021"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.7e-05"
     gene            19429..20280
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
     CDS             19429..20280
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33545.1"
                     /db_xref="GOA:Q4K182"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K182"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVTEMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    19429..20277
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.6e-146"
     misc_feature    19432..20061
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-18"
     misc_feature    19432..20073
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00012"
     misc_feature    19435..20163
                     /gene="rmlD"
                     /locus_tag="SPC18A_0022"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 2.9e-08"
     gene            order(20356..21309,21326..21541)
                     /gene="tnp"
                     /locus_tag="SPC18A_0023"
                     /pseudo
     CDS             join(20356..21309,21326..21541)
                     /gene="tnp"
                     /locus_tag="SPC18A_0023"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    20362..20805
                     /gene="tnp"
                     /locus_tag="SPC18A_0023"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 5.5e-05"
                     /pseudo
     gene            21840..>21887
                     /gene="aliA"
                     /locus_tag="SPC18A_0024"
     CDS             21840..>21887
                     /gene="aliA"
                     /locus_tag="SPC18A_0024"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33547.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ89"
                     /translation="MMKSSKLLALAGVTLL"
BASE COUNT     7101 a   3305 c   4380 g   7101 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaggactgt ataaaagaca gaaatccttt gttttttata actaaggttt ataaactttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactattt aaggagaaag aagatgaaca
      301 taaagaagcg tgtccttagt gcaggcctga cttttgcatc tgctttgctt ttagctgctt
      361 gcggccaatc aggttcagat acaaaaactt actcatcaac ctttggtgga aatccaacta
      421 catttaacta tctattagac tattacgctg ataacatagt caattgaaac aagaacagga
      481 caaaagagcc tcgtaaaagg tatggcaact tggtaatacc tttttgaggt gctttttgat
      541 ataagcccat gttttctcaa taggattgta ctcaggtgag tagggaggaa gaggtaaaag
      601 tttatgccca gactcttcgc ataaaagttc tagcttcccc attctatgga atcttgcatt
      661 atccataata tagtagattg aaactagaat agtacacctc tacttctaaa acattgttag
      721 aattcgattt tactgtcctg atcgatttat cttattctta tttcatttta ctataataac
      781 cgatggtatg gttaatgttg gtaagaaaaa cttctgaaac caagcttcaa aaaagtcgct
      841 cgtcatcgtc tcttcgtaag tcattggagc aattaactca ccatttgtta gccctgcaac
      901 caaagaaatc ctctgatatc ttcttccaga tactttgcct cttattaact gaccttttaa
      961 tgagcgacca tattctcgat aaaaataagt atcgaatcct gtttcgtcaa tataaacagg
     1021 tgctaggtgc tttaaactat taaaattctt aagaaataag gctacttttt ctgggtcttg
     1081 ttcataatta gattgaaact agagtagtac acctctgctt ctaaaacgtt gttagaaatc
     1141 ggtttaaccg tcctgttctt atttcatttt actatatttt tgtttcgcgg gaagtctact
     1201 aagatactta aagatgcaga tagtgaaaat aaaagtgtag acattaccgt aaaaaagtga
     1261 tataatcgta taatgttgaa tgtataggtg ttaatcatga gtagacgttt taaaaaatca
     1321 cgttcacaga aagtgaagcg aagtattaat atagttttgc tgactattta tttattgtta
     1381 gtttgttttt tattgttctt aatctttaag tacaatatcc ttgcttttag atatcttaat
     1441 ctagtggtaa ctgcgttatt cctactagtt gccttggtag ggctactctt gattatctat
     1501 aaaaaagctg aagaatttac tatttttctg ttggtattct ctatccttgt cagctctgtg
     1561 tcgctctttg cagtacagca gtttgttgga ctgaccaatc gtttaaatgc gacttctaat
     1621 tactcagaat attcaatcag tgtcgctgtt ttagcagata gtgagttcga aaatgttacg
     1681 caactgacga gtgtgacagc accgactggg actgataatg aaaatattca aaaactacta
     1741 gctgatatca agtcaagtca gaataccgat ttgacggtca accagagttc gtcttacttg
     1801 gcagcttaca ggagtttgat tgcaggggag actaaggcca ttgtcctaag tagtgtcttt
     1861 gaaaacatca tcgagtcaga gtatccagac tacgcatcga agataaagaa gatttatacc
     1921 aagggattca ctaaaaaagt agaagctcct aagatgtcta agaatcagtc tttcaatatc
     1981 tatgttagtg gaattgacac ctatggtcct attagttcgg tgtcgcgatc agatgtcaat
     2041 atcctgatga ctgtcaatcg agataccaag aaaatcctct tgaccgcaac gccacgtgat
     2101 gcctatgtac caatcgcaga tggtggaaat aatcaaaaag ataaattaac ccatgcgggc
     2161 atttatggag ttgattcgtc cattcacacc ttagaaaatc tctatggagt ggatatcaat
     2221 tactatgtgc gattgaactt cacttctttc ttgaaaatga ttgacttatt gggaggggta
     2281 gatgttcata atgatcaaga gttttcagat ctacatggga agttccattt cccagtaggg
     2341 aatgcccatc tagactctga gcaagcttta ggttttgtac gtgaacgcta ctcactagcc
     2401 gatggagacc gtgaccgtgg tcgcaatcaa caaaaggtca ttgtagcgat tattcagaag
     2461 ttaacttcta cagaggtctt gaaagactat agtagtattc ttcaaggatt gcaggattct
     2521 cttcaaacaa atatgccgat tgagactatg atggatttag tgaataccca gttggaaagc
     2581 ggagggaatt ataaagtaaa ttctcaagat ttaaaaggga caggtcggat ggatcttcct
     2641 tcctatgcaa tgccagacag taacctctat gtgatggaaa tagatgatag tagtttagct
     2701 gtagttaaag cagctataca ggatgtgatg gagggtagat gaaatgatag acatccattc
     2761 gcatatcgtc tttgatgtag atgatggtcc caagtcaaga gaggaaagta aggctctctt
     2821 ggcagaagcc tacagacagg gggtgcgaac cattgtctct acctctcacc gtcgcaaggg
     2881 catgtttgaa actccagaag aaaaaattgc aacaaatttt attaaggttc gtgaaattgc
     2941 aaaagaagta gcagatgatt tagtcattgc ttatggcgca gagatatact atactctgga
     3001 tgctctagaa aagctagaaa aaaaagaaat tcctaccctt aatgatagtc gttatgcttt
     3061 gattgagttt agcatgcata cttcctatcg tcagattcat acgggattga gcaatatttt
     3121 gatgttggga atcacgccag taattgctca tattgaacgt tatgatgctt tagagaataa
     3181 cgaaaaacgt gttcgtgaac tgattgatat ggggtgctat actcagataa atagccatca
     3241 tgtttcaaaa cctaagttct ttggtgaaaa atataaattc atgaaaaaga gagctcggta
     3301 ttttttggaa cgtgatttag ttcatgtagt tgcaagtgac atgcacaatt tagacagtag
     3361 acctccatat atgcaacagg catatgatat cattgctaag aaatatggag cgaaaaaagc
     3421 gaaagaactt tttgtagata atcccagaaa aattataatg gatcaattaa tttaggagaa
     3481 aatatgaagg aacaaaacac tttggaaatc gatggattgc aactattcag agctttatgg
     3541 aaaagaaagt tagtcatttt attagtggca attataactt cttcagttgc ttttacctac
     3601 agtacttttg ttatcaaacc tgagtttact agtacgactc ggatttatgt agttaaccgt
     3661 aatcaggaag agaagcctgg tttaaccaat caagacttgc aggcaggatc atacttggtt
     3721 aaagactatc gtgaaattat cctatcgcag gatgttttgg aggaagttgt ttctggtttg
     3781 aaactagatt tgacgccaaa aggtttggct aataaaattg aagtaacagt accagttgat
     3841 acccgtattg tctctgtttc agttaatgat cgagttcctg aagaggcgag ccgtatcgct
     3901 aactctttga gagaagtagc tgctcaaaaa attattagta ttactcgtgt ttctgatgtg
     3961 acaacactgg aggaggcaag accggcgata tcaccgtctt caccaaatat taaacgcaat
     4021 acactaattg gttttttggc aggggggatt ggaactagtg ttatagtttt tcttcttgaa
     4081 cttttggaca ctcgtgtgaa acgtccggaa gatatcgaag atacactgca gatgacactt
     4141 ttgggagttg taccaaactt gaataagttg aaataggaga gagagatgcc gacattagaa
     4201 atagcacaaa aaaaactgga gttcattaag aaggcagaag aacattacaa tgctttgtgt
     4261 acaaatatac agttgagcgg agataaacta aaagtaattt ccgttacttc tgttagccct
     4321 ggggaaggaa aaacaactac ttccgtaaat atagcatggt cgtttgcgcg tgcaggctat
     4381 aaaactcttt tgattgatgg cgatactcga aattcggtta tatcaggatt ttttaaatct
     4441 cgtgaaaaaa ttacagggct aacagaattt ttatctggga cagctgattt atctcacggt
     4501 ttatgtgata caaacattga aaatttattt gtagttcaat cgggagctgt atcaccaaac
     4561 cctacagcct tgttacaaag taaaaatttt aatgatatga ttgaaacatt gcgtaaatat
     4621 tttgattata tcattgttga tacagcacct attggaattg ttattgatgc ggcaattatc
     4681 actcaaaagt gtgatgcgtc catcttggta acagcaacag gtgagacgaa taaacgtgat
     4741 gtccaaaaag cgaaacaaca attaaaacaa acagggaaac tgttcctagg agttgtttta
     4801 aataaattag atatctcggt tgataagtat ggagtttacg gtttctatgg aaattatggt
     4861 aaaaaataac ttaggaaaga ttttatggat gaaaaaggat tgaaaatttt tctggcagta
     4921 ttacagagta ttgttgtcat tttattgatt tattttctta gctttgttag agagacagaa
     4981 cttgaacgtt cttcgatggt tatactatac cttctccact tttttgtatt ctattttagt
     5041 tcctatggta acaatttttt taaaagaggg tacctagttg agtttaatag tactataaga
     5101 tatatttttt tctttgcaat agctataagt gtattaaact tttttatagc ggaacggttt
     5161 agtgtctcta gaagaggaat ggtatacttc ttaactttag aaggaatatc cttatacttg
     5221 ttaaatttct tagtaaagaa atattggaag catgtgtttt ttaatctaaa aaatagcaag
     5281 aaaattttac tgttaacagt aacgaaaaat atggaaaaag ttcttgataa attgttagaa
     5341 tctgatgaac tttcatggaa attggtagca gtaagtgttt tggataaatc tgattttcaa
     5401 catgataaaa tacctgtaat tgaaaaggaa aaaattattg aatttgcaac gcatgaagtt
     5461 gtggatgagg tgtttgtcaa tcttccagga gagagctacg atattggaga aattatctct
     5521 aggtttgaga caatggggat agatgtaact gtaaatctta atgcatttga taagaatttg
     5581 ggtcgcaata aacaaattca tgagatggta ggattgaatg tagtcacttt ctctaaaaat
     5641 ctttataaaa ctagtcatgt gatttcaaag agaattctcg atatttgtgg tgccactatt
     5701 ggccttattc tttttgctat agctagtcta gttttagttc cattgattcg taaagatggc
     5761 ggaccagcta ttttttctca aactcgtata gggaaaaatg gtcgacattt taccttttat
     5821 aaattccgtt cgatgcggat cgatgctgaa gctatcaaag aacagttgat ggatcaaaat
     5881 acgatgcaag gtggtatgtt taagataaac aatgatcctc gtgttacaaa aattggtcgc
     5941 tttattcgta aaaccagttt agatgagtta ccccagtttt ggaatgtctt tataggagat
     6001 atgagcttgg tgggaacacg tccacctaca gtagacgagt atgatcagta tactccagaa
     6061 cagaaacgtc gactcagctt taaacctggt attacaggtt tatggcaggt tagcggccgt
     6121 agtaaaataa ccgattttga cgctgttgta aaattagatg tggcttatat tgataattgg
     6181 acaatctgga aagatattga aattttgctt aaaactgtta aagttgtatt tatgagagat
     6241 ggagcgaagt aatttctgta tatccatcct attaggagag aaatgaaaaa gtcagtttat
     6301 atcattggtt caaaaggaat tcctgctaag tatggaggat ttgaaacttt tgttgaaaaa
     6361 ttaacagcct tccaacaaga taaggctatc caatattatg tggcttgtat gcgtgaaaac
     6421 tctgcaaaat cagggactac tgaggatgtt tttgaacata atggtgctat ctgttataat
     6481 gtcgatgttc ctaatattgg tccagcgcga gctatagcgt atgatatcgc tgcaattaac
     6541 agagctattg aaattgctaa agaaaataat ggtgaagatc caatcttcta tattttagct
     6601 tgtcgaattg gtccgttcat ccatggaatt aagaaaagaa ttcaagcaat aggtggggct
     6661 cttctggtta atccggatgg tcatgaatgg ctacgagaaa aatggagttt acctgttcgc
     6721 aaatattgga aatactctga aagacttatg gtcaaacatg cagatctttt agtgtgtgat
     6781 agtaagaata ttgaaaaata tatccaagaa gattataaac agtatcaacc taagacaacc
     6841 tatatcgctt atgggactga tacaacacgc tccatattaa agagtagtga cgaaaaagta
     6901 cgttcttggt tcaaagagaa gaatgtttct gaaaacgagt attacctagt tgtaggacgt
     6961 tttgttccag aaaataacta tgaggctatg atacgtgggt ttttagcatc taattctaag
     7021 aaggactttg tcttaatcac aaatgtagaa cagaataaat tttataatca gttgttggca
     7081 aaaactggtt ttgataagga cccacgagta aaatttgtag gtacagtcta tgagcaagag
     7141 cttcttaaat atattcgtga aaacgccttt gcttacttcc acgggcatga agttggtgga
     7201 accaatcctt cgcttttaga agctctggca tcaactaaac tgaatttatt gctagatgtt
     7261 ggctttaacc gagaagttgg ggagcaaagt gcgatctatt ggaaaaaaga tgagctttcc
     7321 caagtaatcg agaaagttga gcaatttgat gcaaaaatga ttgatgagtt agatagacaa
     7381 tcaaatcaga gaattacgga ttctttcact tgggaaaaga ttgtcacaga ctacgagaaa
     7441 ttatttaaaa aatgaaaata ctacattata ctttaggatt tcaaccccag cgaacaggtg
     7501 gtttggttaa atatgctgag gatttaatga tagagcaaat tgctcaaggt tatcaagtag
     7561 ccgccctatg tccagggaga attaagttct tttcaaaaaa aatagaaata attaaagcga
     7621 cgtcaaggca gtttgagtgt tatgaactgc ttaatagctt acctatagct ttatttggag
     7681 gtatatccga tccaactgct ttcatgacac cttgtgacaa aaatgtttat cgtacttttt
     7741 tagaaaaagt acaacccgac attatacata ttcactcgtt tatgggattg cataaagaat
     7801 tcctcgaaat tgctaaaaac ttgaatatta gagtggtttt tacgagccat gattattatg
     7861 gattagcacc cgtacctcat ttctatttta atggggtgga ttatagtgat aaaaatacaa
     7921 acttaacatg gaatattatg tcttccaatg ctttaagtgt gaaaaaacta agactttttc
     7981 aagtttcatt ttatcctact attcgtaaac ttttgaaact attagggaaa aatccaaaat
     8041 ctaaaaagaa tttagttatt cgagatgtta ttgaggaaca agattatagt gaacttcgat
     8101 actattataa tgagatgttt cacttaatag atggttattt gtttaatagt agacttgcaa
     8161 agaaggtata tgagataaac gagattcaac cagctaatag tgtagtatta tctataacaa
     8221 gtagttcaat taaacatcat cagagattaa cgactacaaa taataagatt agggtttctt
     8281 atattggttc agacgaagaa tataaaggtt actttgattt tattgacttt gctggaactt
     8341 tagaacaaga atcatatgaa gtggtaactt atggtcattt accaaatgaa gagtgccctt
     8401 cattcattga acaaaaagga tattttacca aggaaacgat tgacagtgtc tatgaaaata
     8461 ttgatatttt gattatagca agcaaatgta aagaaacctt tggattgata acagtagaag
     8521 cattatccta tggggtaaat gtttttgtga gtgaaaatgt tggatcaaaa gacttgcttc
     8581 cagaaacaca tgtttttaaa gacaaggaag atttgttggc taaaatcatc aataatcagt
     8641 tggagaaagt tccgcttaaa acgatggaaa aacatgtaga agaagttatt agttattaca
     8701 aacaggttag aagcaacaat taaggagaat gattaaagat atgtcctgtc cagaaattag
     8761 cgtaattgta ccagtttata atgtggaacg atatttaaga cagtgtatgg attcattgat
     8821 aaatcaaact tatagggatt ttgaaataat tttagtaaac gatggatcaa cggattcttc
     8881 tgggattctc tgtgaagagt gggcaaaaaa agatgaaaga attcatgtag ttcacaaaaa
     8941 aaatgagggg cttggcttcg ctcgtaatac aggggttgaa cacgcaaagg ggaaatacat
     9001 aacctttgta gattcagatg actatgtttc tctagatatg ctgcaaactc tatataatgc
     9061 tgttcaagaa tatgatgtcg aagttgtata cagtgcggga tattatcgtt cctttagtaa
     9121 tggagaaata aagaagacag atgtaggaac aaaaaagcct caacttttcg aaggaggaga
     9181 tgttgcctct gaattactcc ctaatgtaat ttctgctcct cctgaatatc cgaatgatgg
     9241 gaaagttgga gtgtcggcat ggaaggttct ctataaagct aatttattta aggataaagg
     9301 gctattattt cattcggaaa gagaattcat ttcagaagat gctatttttc aaattgattg
     9361 tttaaaatta gcaacatctg cccttgttat cccagatatt ttatactact atcgtgaaaa
     9421 ctttggttct ttaagtatga aatataaaga agatcggttt gagttggata agatcttgta
     9481 taacgagcaa ttaaaaagag ttgaggggtt acctaatcaa gaaattttgg aagaaagaat
     9541 cgagagaatt ttaattgcta atattcgttt atgtgtcttt caggaatctt tacataaaag
     9601 ttctagaata cataaacgct tgcaaagaat tagacagatt tgtaaggatc cagtctcaaa
     9661 agtagtttta caccactatc caatccatcg cttacctttt cctaaacgtt tgatctgtgt
     9721 attagctaag tataatatgt cgctgtttct tttagcttta accctattaa aatatcggaa
     9781 tcggagtgta taacttttat ggggatgaat atagaaaaat taaaactatc tttgaaaaat
     9841 agaacgtttt ttcctgttgt tattcatgcc ttacgtaacc gttggccctt gtggtggatt
     9901 cggagtaagg ctattcgaga agtacaactt gaagataggg cctacagaat actaaaaaag
     9961 aaatacggtt ccttaatttc aaactctttt gataaagcat acttatcaga aaaagttccc
    10021 aagcaaatct ggatttgctg gtttcaaggt atggagaatg ctccagattt ggtgaaatca
    10081 tgttatagat cacttaaaaa gcaatttcct gaatatgtca ttacggttat ttcttcagag
    10141 aatatttttg aatatgtaga gatacctgat attctatatg aaaagtgggt gaatggtgta
    10201 ataggcaatg ctcatttttc tgatatcctt cgggtagagt tgttacgtaa gtttggagga
    10261 atatggattg actctacagt gtattgtaca ggaattacta ccatacagat aattggaaaa
    10321 aatccatttt ttatgtataa aagtgtatct tcggtcgagg agaggatctc ctcttccaac
    10381 tggatgattg cttctgttcc taatcatcca ttcatgatta cgatgagcaa acttttgcaa
    10441 tcttattggt caaaagaagt tatagcaatt cattattatc tatttcatat tctttttacg
    10501 attatgatag aatcacttcc tgagttgtgg cagcttgtac ccacctatac gaacgcagca
    10561 ccacatataa tgattgatga attaaataat gttttttcaa aggaacgtta ccagcaattg
    10621 tgtcaaattt cagattttca taaattaaat tataaaaaaa attacaatga taaatcagag
    10681 agtttgtaca gttatttact gaatcagtag aggggagaat cttgcctagt ttaaagaaaa
    10741 atattgttta caatgtctta tatcagatct tagctgtaat agtaccattt attacctcac
    10801 cttacttagc gcgtgtgtta ggtgcagagc aaattggagt ttattctttt acttattcca
    10861 ttgcttttta ctttatgatt ctgtccatgt tggggatttc taattatggg aatcggacaa
    10921 tagcacgggt acgaacaagt agagaacatt tgaatcagga attttcgaat atttacgcgg
    10981 ttcagttgac gtgttcacta gtaatgacca tctcatattt gatttatgca acagtatttg
    11041 tgaatagttt tcagattgta gcctatatcc aagtattaca tgttttatcg tatgcaacag
    11101 atgttagttg gtttttttat ggtcttgaag agtttcgtat tacggttgct aggaattcat
    11161 ttgttaagtt attaacttta atatctatct ttacatttgt aaaaagccct aatgatatct
    11221 atttatatac ctttataatg gcagggggta ccctgcttgg tcagttgatt acatggccat
    11281 ttttgctaaa acaagtaaac tttgtgtgcc ctagtcttgg aaaaataaag aaacacatga
    11341 aacctattat tattttattt ttccccgtct tagcggttag tattttttcg tttctagata
    11401 aaataatgct tgggatgtat agtagtttga aggaaactgc tttttatgag aattcagata
    11461 agatcattag tattccaaaa gctctgattc aagcctttgg agctgtaatg ttgcctcgaa
    11521 cagtacattt actgagtata ggtgatgaac aaaaaagttt agaatatgtt gataaaacga
    11581 tgtgggctgt tttagtgatt acaatgggct gtgctttcgg tttagcagga gtttctgcaa
    11641 cctttgctcc tgtttattgg ggtgaagaat ttagagccag tagccaaatt attgcaggaa
    11701 tgacaccggc tttagtattt tcggcttttg gaaatgtcat ccgaacccag tttttaattc
    11761 cacgaagttt tgacaaggaa tatacggtat ctttacttta tggagccgtt gttaatattt
    11821 tgattaatat tcttttaatt ccgaagatag gagcaatggg agctgttatc ggaacaattg
    11881 ttgcagagtt agttctatgt tgctatcaaa catggattgc tagaaattat ttacatatca
    11941 gagaatatct gataaatgct gggatattat ttcttatcgg ttcagtaatg tatatggttt
    12001 taattcttat ttcaagtatt ttacctactt cgttacttac acttattatt gaaattatag
    12061 tcgcagcttt catttatatt agtttactga ttctgcatat cttttcttca aaaaacaggg
    12121 taattattgg tttacgaaca aattttttag aacgtactca tttatttaaa aggaagtaat
    12181 agtgaaattt aaatttaaat ttaatccaat cgcgatactg tatatattgc tagtatactt
    12241 agagttagct acagataggc aacatctgta tcctgtaacg tacatgacaa aatattatat
    12301 tggtatttta atcactgtgt tgtttgtttt gttattagta ggccgtggga agcttatttt
    12361 tgttaataaa aaattattat atcttgctaa gatattagct ataccaacaa ttgttctttt
    12421 cctgtactca gtcttactag acgtaatgaa cccagttgaa tttgatggat attttagtag
    12481 gttatcaagt acgactattt ttggtttgtt agctatcttt caagctatag ttgtttttca
    12541 attttttgga caaaaagtag tagattacac ttttacagct atctccctca gctacttaac
    12601 cagtatcatt gttgccttta ggcagggagg acttagtcaa tttatcttga tgctaacaga
    12661 tgatagtttc aatggttcgg tactagaaat gcatgaagtt gcacctatta cagctctctt
    12721 tattctgtac tatttgtaca aatattttat aaaagaaaat agtttttctt cagtatttcg
    12781 taatatctta atagctctca ttattctttt tttaagcctt aaacgaatcg tttttttgag
    12841 tgtattaatt atcataccag tatttttgat aatttattgg tatgataaaa aagtaagcaa
    12901 actagggaaa gaacgaaaaa ttttaagttt attaaatagc ttttccttaa tatttataac
    12961 aggaatattc ctttatgttt atagtgtaaa atctggtttt atatatacat ttattcaaga
    13021 acataatatt aattcgatgg ctagaacaga tttatggaag ggaattgaat caacctatag
    13081 tttcgcccct atatttatgg ggagagggat agggtttgta acaaaatgga tggataataa
    13141 ttggatgact ttgaatatca atggtcttac agagtcaacg gggctccata atgatatttt
    13201 gaagtactac attgagatag gatttgtagg attatttatt tatttttaca ctcttcttta
    13261 tagaaatgct aaacgtatat ttgtaaaaat tggtcataaa gaatcattta tatattttgt
    13321 attgataatg tttcagatgc tgatatggtt tacagataat atttcaactt accataattt
    13381 tttatggatt ctaaatctac tgctcttttc tttaactaat acggatgcag aattggaaac
    13441 tcagaaatta taaaatattt atttcttgaa tttatggtct tacgccgtaa atttgatttc
    13501 actaatgact aatactaatt tataaaaata atatgaaatt ttatataaaa aatttattaa
    13561 aaaaagtctt tacattaccg ttgcatttat tgcctattca gtctaataag ataatatttg
    13621 ataattttgg tggtagaggt tttggggaca atcctaagta tatacttgaa gaacttgtct
    13681 ctcgagaaaa gaatctaaat cttgtgtggg taacaaaaga tagagaaatt tctatccctg
    13741 aaggcgttcg agtagtaaaa tacggcagtt accgttcttt ttatgaatgg ttaacagcta
    13801 gagtttgggt agataatatt cgtaattctg atcgaccttg gaagcgaaaa ggacagattt
    13861 atcttcaaac ttggcatggt tcagatgggg taaagttaat tgaaaaaagt gttgcaggga
    13921 atctaaaaaa aacatatctt agaatggcga agtatgatgg aaagattaca gacggtatcg
    13981 tatcaagtcg gcactttcaa actttgggta tgcaaaataa tttttggctg acagagaatg
    14041 tggaatttct ggaatttgga ttacctcgaa atgatgattt ttttaaaagt gaaaaaatca
    14101 aaaccacaaa tataaaattt agaacattat ttgatatcga tttagacgaa ctggtagttt
    14161 tgtatatgcc gacgttcaga gatgatggat cgttgaatgc ctataattta gattactcga
    14221 aactaataca tgtttttcaa aataaattta gaaaaaatgt aaaaatatta gttcgttttc
    14281 atccaaatgt tgattctaat tttataaatt tacaggatac agactgtata aatgtgtcga
    14341 cctattcaaa tcctcaggat ctgatgatga gtgcggatgt gatgattacg gattattcat
    14401 cggcttctat tgattttatg ttattaaatc gtccagtatt tctgtattta ccagattatc
    14461 aaagttatgt gaatgataga ccattggatg ataactttga taaattgcca tttccaagag
    14521 catatcataa caatgagttg acagaaatta ttagagactt tgaaagaagt aaatatgatg
    14581 aaaaagttcg tctgtatgaa ttagaggatg ttcgttttga tagaggaaaa gcatcagtac
    14641 agtgtgctaa ttggattgaa gaaaaaataa aaaacaataa agttattgat tgaaataatt
    14701 atatttattg aatgataaat aaggaggcct ttagatgaaa agaattataa catatggtac
    14761 atttgattta ttgcattatg gtcatatcag tcttttgaaa cgtgctaaac agctaggtga
    14821 ttatttgatt gtagttgttt caagtgatga gtttaattta aaagaaaaga ataaagtatg
    14881 ttactttaac tacgaacaca gaaaaaattt agtagaagct attcgatatg tcgatttagt
    14941 aatccctgaa actagttggg aacagaaaaa gtcagatgtt aaagagtacc atattgacac
    15001 ttttgtaatg ggtgatgatt ggaaaggtaa atttgattat cttgaagaag aaggtgttga
    15061 agtagtctat ttgcctagaa caaaggaaat atcaaccaca aagataaaag aagatttatc
    15121 ggaataaaat attattaaaa aatgctgaca taagaaattg tggcttttgt gtatagtttt
    15181 tgatagaata aagtaacaac actttaacca atgaggtgtg aataatggca gtaattttta
    15241 aagatgtact tgttgaagag aagactgatg aagaaaaaca acatatttta tctattttag
    15301 atgatgagaa tgttagagct tttgattgtg gatattaaga attgaatgat gttttttgat
    15361 atttagaaca aatacgatga agaaacaggc catgtattgc ctattgtaaa tcaaaatttt
    15421 gaattattag gttttatttc ttgtagacta gtatcatttt ctttcatagc tcgggttaaa
    15481 gagatgggaa ttagcataga ttatcttggt gtttataagg attgccagaa aatgggggat
    15541 cggttcgctt ttggtgacct ttgcacttcg attatcttta actattgact gttgattacc
    15601 aataaaaggt gtaatagttc atgctttaga ggatgttgta gaattctatg acaaactggg
    15661 ttttattgac cctagagata tagtgattta taatggcaaa ccggttacta tatattttag
    15721 taatagactt cctgcaaaac tagaatccta gttcatgatt gataatacca gcattcaaat
    15781 tcattcgtaa tccgaagcgt ttacgatgat ttcgataggt tgttgaaaac attttaaaca
    15841 tttttacttt ggcaaagatg ttctcaacct tgcttctctc cttagatagc gcatggttac
    15901 aggctttatc ttcagctgtt agtggcttga gtttgctgga tttacgtgga gtttgtgctt
    15961 gaggatatat cttcatgagc ccttgataat cactgtcagc caagatttta ccagcttgtc
    16021 cgatatttct gcgactcatt ttgaacaact tcatatcatg gcaatagaaa caattctccc
    16081 ttgacttgtg acaatcgctt gagccttcat agcgtggcat ttctttttac cagaatcatt
    16141 cgctaattgt ttttttaggt cgattgattt ttacttccgt cgcatcaatc attaccgtgt
    16201 cctcaaaact aagaggagtt cttgaaatcg taacaccact ttgaacaaga gttacttcaa
    16261 cccattggct ccgacggatt aagttgcttt cgtggatacc aaaatcagcc gcaatttctt
    16321 cataagttca atattctcgc acatattgaa gagtggccat aagaaggtct tctaggctta
    16381 atttaggttt tcgtccacct tttgcgtgtt taagttgata agctgttttt aatacagcta
    16441 acatctcttt aaaagtcgtg cgctgaacac caacaagacg cttaaatcgt gtatcagtta
    16501 attgtttact tgcttcataa ttcatagaac tactatacca tattttgttt cgcaggaagt
    16561 ctattgaaaa attaagaaat ggtgaaatta ttcctcacac acagttattt gaaacatcct
    16621 tagaaaatga tttttaattg tatgcaaaca aagtagaatt cacttatttt atcttatgct
    16681 aaatgtaata tgaaacaagt gaatttttat agacaaagaa gaatttttct gtaattttta
    16741 gataataatt ttaaaaaatg tgatgattat tttcttttta gagcagtaca gaattaatag
    16801 taattgactc taaatcaata aagaaaggta ccctattatg aaaggtatta ttctagcagg
    16861 tggttcggga actcgcttgt atcctttgac tcgcgctgca tcaaaacaac tgatgccggt
    16921 ttatgataaa cccatgattt actatccact ttcaacattg atgttggctg ggattaggga
    16981 tattttgata atctcaactc ctcaagattt gcctcgtttt aaagagcttc ttcaagacgg
    17041 atctgagttt gggatcaagc tttcttatgc agagcaacca agtccagatg gtttggcaca
    17101 agcctttatc attggggaag agtttattgg tgatgatagc gttgctctaa tcttaggcga
    17161 caatatctat cacggacctg gcctttctaa gatgttacaa aaggcagcag gtaaggagtc
    17221 gggagcaact gtttttggct accatgtcaa ggatccagag cgctttggtg tggttgagtt
    17281 tgatcaggat atgaaggcta tttctattga agaaaagcca gagcaacctc gttcaaacta
    17341 tgcagttaca ggtctctatt tctatgataa tgatgtagta gagattgcca agagtattaa
    17401 accaagtcct cgtggtgaac tggaaattac agatgtaaac aaagcttacc tagatcgtgg
    17461 tgatttgtct gttgagctta tgggacgtgg ctttgcttgg ctggatactg gaactcatga
    17521 aagtttacta gaggcttcac agtacatcga aacagtgcaa cggatgcaaa atgttcaggt
    17581 agcaaactta gaagaaattg cctatcgcat gggttatatc agtcgtgaag atgtattgac
    17641 cttagcccaa ccacttaaga aaaatgaata cggacagtat ctgctccgtt tgattggaga
    17701 agcatagatg acagataatt ttttcggtaa gacgcttgcg gcacgcaagg ttgaagctat
    17761 tccaggcatg ttggagtttg atatccccgt tcatggagat aatcgtggct ggtttaaaga
    17821 aaatttccaa aaggaaaaaa tgcttccact tggatttcca gagtctttct ttgcagaagg
    17881 aaaattgcaa aacaatgtat ccttctcacg taaaaatgtc cttcgagggc tccacgcaga
    17941 gccttgggat aagtacatct ctgtagcaga tggagggaaa gttctgggtt cttgggttga
    18001 tctacgcgag ggtgaaacct ttgggaatac ctatcagaca gtaattgatg caagcaaggg
    18061 aatctttgtt cctcgaggcg tagctaatgg cttccaagtt ctatcagata cagtgtcata
    18121 tagctatctg gtcaatgatt actgggctct cgagctcaaa cccaagtatg cctttgtgaa
    18181 ctacgctgat ccaagccttg gtattgaatg ggaaaatatt gcagaagcag aggtttcaga
    18241 agcagataaa catcatcccc tacttaagga tgtaaaacct ttgaaaaaag aagatttgta
    18301 aaaaggaaag aatatgactg aatacaaaaa tattatcgtg acaggtggag ctggctttat
    18361 cggttctaac tttgtccatt atgtttacga gaactttcca ggtgttcacg tgacagtcct
    18421 agataagttg acttatgctg gaaatcgcgc gaatattgag gaaattttag gtaatcgtgt
    18481 tgagttagtt gttggtgaca ttgctgatgc ggagttggta gacaagttgg ctgctcaagc
    18541 agatgctatc gttcattatg cagcggaaag ccacaatgat aattcactca atgatccatc
    18601 gccatttatt catactaact tcatcggaac ctatactctt ttagaagctg ctcgtaagta
    18661 tgatattcgc ttccaccatg tatcgacaga tgaagtttat ggggatctcc ctttacgcga
    18721 agatttgcca ggtcatggtg aaggaccagg tgagaaattt actgctgaaa caaaatacaa
    18781 cccaagctct ccgtactcat caaccaaggc agcctcagat ttgattgtca aagcttgggt
    18841 gcgttctttt ggagtcaagg caacgatttc caactgttca aataactacg gtccttatca
    18901 acatatcgaa aaattcatcc cacgtcagat tactaacatc ctaagtggaa ttaagccaaa
    18961 actttacggt gaaggtaaga acgttcgtga ctggattcat accaatgacc attcttcagg
    19021 agtttggaca atcttgacaa aagggcaaat cggtgaaacc tacttgattg gggctgatgg
    19081 tgagaagaac aataaggaag ttttggaact tatccttaag gaaatgggac aagctgcgga
    19141 tgcctatgat catgtgactg accgtgcagg acatgacctt cgctatgcga ttgatgccag
    19201 caagctccgt gatgagttgg ggtggaaacc tgaatttact aactttgaag ctgggctcaa
    19261 ggcaacaatc aagtggtata cagataacca agaatggtgg aaagcagaaa aagaagctgt
    19321 tgaagccaat tatgctaaga ctcaggagat tattacagta taaaaagcag gaaatagctg
    19381 ctttttattg ctatattggg aagagttaca tattagaaag gtctagagat gattttaatt
    19441 acaggggcaa atggccaatt aggaacggaa cttcgctatt tattggatga acgtaatgaa
    19501 gaatacgtgg cagtagatgt gactgagatg gacattacca atgaagaaat ggttgagaaa
    19561 gtttttgaag aggtgaaacc gactttagtc taccattgtg cagcctacac cgctgttgat
    19621 gcagcagagg atgaaggaaa agagttggac ttcgccatca atgtgacggg gacaaaaaat
    19681 gtcgcaaaag catctgaaaa gcatggtgca actctagttt atatttctac ggactatgtc
    19741 tttgacggta agaaaccagt tggacaagag tgggaagttg atgaccgacc agatccacag
    19801 acagaatatg gacgcactaa gcgtatgggg gaagagttag ttgagaagca tgtgtctaat
    19861 ttctatatta tccgtactgc ctgggtattt ggaaattatg gcaaaaactt cgtttttacc
    19921 atgcaaaatc ttgcgaaaac tcataagact ttaacagttg taaatgacca gtacggtcgt
    19981 ccgacttgga ctcgtacctt ggctgagttc atgacctacc tagctgaaaa tcgtaaggaa
    20041 tttggttatt atcatttgtc aaatgatgcg acagaagaca caacatggta tgattttgca
    20101 gttgaaattt tgaaagatac agatgtcgaa gtcaagccag tagattccag tcaatttcca
    20161 gccaaagcta aacgtccgct aaactcaacg atgagcctgg ccaaagccaa agctactgga
    20221 tttgttattc caacttggca agatgcattg caagaatttt acaaacaaga agtgagataa
    20281 gtagtagaat gattttctag tctaataaaa gaggcagata atgaactcca aaggagctta
    20341 agatgtacga ttatcttgtt gttggtgctg gtctctttgg cgcatagctt tggctcagtt
    20401 tctattatcg ctcacaccat ccatcagaag tttaatctga aggtacccaa ttatcgtcaa
    20461 gaagaagatt gggctaggat gggtttacca atcacacgta aggaaatctc taattggcat
    20521 atcaaggcaa gtcaatacta tttagagtcc ctttataacc ttttacgaga aaagttgtta
    20581 gaacaacctc ttcttcatgc ggatgaaacc tcttatcggg ttctagggag tgatagccat
    20641 ctgacctact attggacctt tttgtctggg aaagctgaga atcaagcaat cacgctgtac
    20701 catcatgatc agcgtcggag tggttcggta gtgcaagaat tcctaggaga ttattctggc
    20761 tatgtgcatt gtgatatgtt gcggcagtaa cttaggactt tagtcctcta gttctgccta
    20821 tgcgatagca gtccaaggtt taggagcaag gcgacgctaa gcttggtaaa ctgcgaaccg
    20881 ctagaagctt atcgtcaact ggaagaagct gaacttgttg gatgttgggc acatgtgaga
    20941 aggaagtttt ttgaagcgac ccccaagcaa gcagataaat catccttagg agctaaaggt
    21001 ttagcttatt gtgatcagtt attttccctg gaaagagact gggaggcttt gccagctgat
    21061 gaacgactac agaaacgtca agaacatctc cagcccttaa tggaagactt ctttgcttag
    21121 tgccggcgtc agtcagtttt agcaggttca aaactaggaa gggcaattga atacagcctc
    21181 aagtatgaag aaacctttaa gactattttg aaagacggac atctggtcct ttccaataat
    21241 ctagctgaac gcgccattaa atcattggtt atgggacgga gtaaaagagt ccagtggact
    21301 cttttagcct aagctaaatt ttaaaaagcg agggtggtta ttttctcaaa gttttgaagg
    21361 agctaaagca agaactatta ttatgagttt gttggaaaca gctaaacgtc atcaattaaa
    21421 tagcgagaaa tatctattct atcttctaga atgtctttca aacgaggaaa ctctcgtaaa
    21481 caaagaggtt ttagaggctt atttaccatg gactaaagtt gtacaagaaa agtgcaaata
    21541 agaaatctcc agattaggaa ctatccgtga gttctctagt ctggagattt ttcggctctt
    21601 tgtcaactgt agtgggttga aaaaaagcta agctcgagaa aggacaaatt ttgtcctttc
    21661 tttttttaga aatagtatta aaaattcctt gactatgtga tatagttgag ggatttttaa
    21721 atgatattca tattttttgc aaagatgttg tttgaaaaat aattttcaaa aattctgaaa
    21781 attctgttga catctttctg aaaagagtct ataatggaga gaaagtttta aaggagaaaa
    21841 tgatgaaaag ttcaaaacta cttgcccttg cgggcgtgac attattg
//
