LOCUS       CR931675               18617 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain Nr. 141/68 (serotype 19a).
ACCESSION   CR931675
VERSION     CR931675.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18617)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 18617)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..18617
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Nr. 141/68"
                     /db_xref="taxon:1313"
     gene            <1..136
                     /gene="dexB"
                     /locus_tag="SPC19A_0001"
     CDS             <1..136
                     /gene="dexB"
                     /locus_tag="SPC19A_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI33621.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K117"
                     /translation="ANEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVEMTD
                     "
     gene            complement(267..1697)
                     /gene="tnp"
                     /locus_tag="SPC19A_0002"
                     /pseudo
     CDS             complement(267..1697)
                     /gene="tnp"
                     /locus_tag="SPC19A_0002"
                     /note="member of homology group 17; member of homology
                     group 17"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1202 transposase"
     misc_feature    complement(693..1193)
                     /gene="tnp"
                     /locus_tag="SPC19A_0002"
                     /note="HMMPfam hit to PF00665, Integrase core domain,
                     score 1.8e-21"
                     /pseudo
     gene            1852..3297
                     /gene="wzg"
                     /locus_tag="SPC19A_0003"
     CDS             1852..3297
                     /gene="wzg"
                     /locus_tag="SPC19A_0003"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33623.1"
                     /db_xref="GOA:Q4K116"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K116"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSEIENVTQLMSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEHPDYASKIKKIYTKGFTKKVEAP
                     KTSKDQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGVDVYNDQ
                     DFTSLHGKFHFPVGNVHLDSEQALGFVRERYSLADGDHDRGRNQQKVIAAILQKLTSS
                     EALKNYSRIIDSLQDSIQTNMPLETMINLVNAQLESGGTYKVNSQDLKGMGRTDLPSY
                     AMPDSNLYMMEINDSSLASVKTAIQDVLEGR"
     misc_feature    1852..1968
                     /gene="wzg"
                     /locus_tag="SPC19A_0003"
                     /note="Signal peptide predicted for SPC0963 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    2056..2403
                     /gene="wzg"
                     /locus_tag="SPC19A_0003"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 2.7e-63"
     misc_feature    2581..3024
                     /gene="wzg"
                     /locus_tag="SPC19A_0003"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 3e-72"
     gene            3299..4030
                     /gene="wzh"
                     /locus_tag="SPC19A_0004"
     CDS             3299..4030
                     /gene="wzh"
                     /locus_tag="SPC19A_0004"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33624.1"
                     /db_xref="GOA:Q9ZFU0"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFU0"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTSDVLDKLEKNRIPTLNNS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELINMGCYT
                     QVNSSHVLKSKLFGERYKFMKKRAQYFLERDLVHIIASDMHNVDSRPPHMAEAYDLVS
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    3302..3910
                     /gene="wzh"
                     /locus_tag="SPC19A_0004"
                     /note="HMMPfam hit to PF02811, PHP domain, score 5.8e-37"
     gene            4036..4731
                     /gene="wzd"
                     /locus_tag="SPC19A_0005"
     CDS             4036..4731
                     /gene="wzd"
                     /locus_tag="SPC19A_0005"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33625.1"
                     /db_xref="GOA:Q9ZFT9"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFT9"
                     /translation="MMKEQNTIEIDVFQLLKTLWKHKLIILLVALVTGAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGTYLVKDYREIILSQDVLEKVATNLKL
                     DMPAKTLTSKVQVTVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIIAVTRVSDV
                     TTLEEARPAMTPSSPNVRRNTLVGFLGGAAVTVITVLLIELLDTRVKRPEDVEDVLQM
                     PLLGVVPDFDKMK"
     misc_feature    4057..4473
                     /gene="wzd"
                     /locus_tag="SPC19A_0005"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.8e-56"
     misc_feature    4579..4656
                     /gene="wzd"
                     /locus_tag="SPC19A_0005"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4741..5430
                     /gene="wze"
                     /locus_tag="SPC19A_0006"
     CDS             4741..5430
                     /gene="wze"
                     /locus_tag="SPC19A_0006"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33626.1"
                     /db_xref="GOA:Q9ZFT8"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFT8"
                     /translation="MPTLEISQAKLELVKKAEEYYNALCTNLQLSGDDLKVFSITSVK
                     AGEGKTTTSTNIAWAFARAGYKTLLIDADMRNSVMSGVFKSRERITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFTTMLETLRKYFDYIVVDTAPVGVVI
                     DAAIIMQKCDASILVTKAGETKRRDLQKAKEQLEQTGKSCLGVVLNKLDTSVEKYGSY
                     GSYGNYRKQKK"
     gene            5445..6806
                     /gene="wchA"
                     /locus_tag="SPC19A_0007"
     CDS             5445..6806
                     /gene="wchA"
                     /locus_tag="SPC19A_0007"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33627.1"
                     /db_xref="GOA:Q9ZFT7"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFT7"
                     /translation="MSEKLAKPSVAIVQSFLVILLTYLLSAVRETEIVSTTAIVLYIL
                     HYFVFYISDYGRNFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LLLHVFLVYVLNPFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESDDVVGEL
                     VAVSVLDKPDFQHDDLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDWARNKQICEMAGLNVVTFSTTFYKTSHVIAKRIIDIVGSLVGLILCG
                     LVSIVLVPLIRKDGGSAFFAQTRIGKNGRHFTFYKFRSMCVDAEEKKRELMEQNTMQG
                     GMFKVDDDPRITKIGHFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPEQK
                     RRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDGWTIWKDIEILLKTVKVVLMKD
                     GAK"
     misc_feature    6222..6803
                     /gene="wchA"
                     /locus_tag="SPC19A_0007"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 1.8e-158"
     gene            6812..7555
                     /gene="wchO"
                     /locus_tag="SPC19A_0008"
     CDS             6812..7555
                     /gene="wchO"
                     /locus_tag="SPC19A_0008"
                     /note="member of homology group 33"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33628.1"
                     /db_xref="GOA:Q9ZFT6"
                     /db_xref="InterPro:IPR004629"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFT6"
                     /translation="MNERIQILGITIDPLTMKETVDAVEQYVLKKHPLHLMGVNADKI
                     NQCYEDEKIKKIVNESGIINADGASVVLASKFLGTPVPERVAGIDLMKHLLELSNEKG
                     YSVYFFGAKEDVLQDMLKIFEERYPALNVVGYRNGYFSPEDEKHIQEDIKEKKPDFVF
                     VGITSPKKEYIIQSFMDNGINAVFMGVGGSFDVLSGHIKRAPLWMQNAHLEWLFRVAN
                     EPKRLFKRYFVGNVSFIRKVLRAKRGYKL"
     misc_feature    6974..7489
                     /gene="wchO"
                     /locus_tag="SPC19A_0008"
                     /note="HMMPfam hit to PF03808, Glycosyl transferase
                     WecB/TagA/CpsF f, score 3.8e-91"
     gene            7552..8376
                     /gene="wchP"
                     /locus_tag="SPC19A_0009"
     CDS             7552..8376
                     /gene="wchP"
                     /locus_tag="SPC19A_0009"
                     /note="member of homology group 95"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI33629.1"
                     /db_xref="GOA:Q4K110"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4K110"
                     /translation="MNQTEIVKLIQKVELDAIKEFQKICKENNIDFFLRGGSVLGAVK
                     YDGFIPWDDDMDIAVPREGYDKLPGIFKDRIIAGKYQVLAYQYCDTLHCYFPRLFLLE
                     DERKRLGLPRNTNLGLHLIDIIPLDGAPNHSFLRKLYFGKVYWYRFLASLGTTYVGDH
                     VDMHSAKQKLIIGFFKKLGFAKLFPQNYVYRRLDNLYKKYDWKKQKYAGTINASLFAK
                     EVMPVEIWGEGVEKPFEDAFFKVPTEYDRYLKRLYGENYLHEEPSDDEKKSHLGGQ"
     misc_feature    7624..8313
                     /gene="wchP"
                     /locus_tag="SPC19A_0009"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     1.2e-104"
     gene            8378..9256
                     /gene="wchQ"
                     /locus_tag="SPC19A_0010"
     CDS             8378..9256
                     /gene="wchQ"
                     /locus_tag="SPC19A_0010"
                     /note="member of homology group 43"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33630.1"
                     /db_xref="GOA:Q4K109"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K109"
                     /translation="MFCYIILHYKVLEETISCVKSIKEGNSNTKQIVIIDNFSNNGTG
                     EKLQELYESDSEIDVLINHENAGFARGNNVAYQFAKEKYKPDFMVIMNNDIEIETEEF
                     EKIVTDIYRKEKFHLLGPDIFSTTYQLHQNPKRLTHYTYEEVKALNEKFKKGSQVSLA
                     LKIKCWLKSSKVLRTAIYQNRRKKKSVDYRKQVENPILHGSFIVYSRDFIEKEEYAFN
                     PNTFFYYETEILDYEAELKGYKRIYTPKIKVLHHQNVATNQVYTNLVEKTLFSNKCNF
                     ESTSYFLKLMKENEGV"
     misc_feature    8384..9019
                     /gene="wchQ"
                     /locus_tag="SPC19A_0010"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 6.3e-10"
     gene            9257..10591
                     /gene="wzy"
                     /locus_tag="SPC19A_0011"
     CDS             9257..10591
                     /gene="wzy"
                     /locus_tag="SPC19A_0011"
                     /note="member of homology group 161"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33631.1"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFT3"
                     /translation="MTYLFLLCLTLFLLTFFYFFAFNQDLIAPPVVMSVMFLISSVFA
                     LINVQNWNIEYSGLAYLLIISGIIVFSMPLLALNSPSLNTKIKVTDRLIDIQFWKIAL
                     TIIVDLIILYLYRREIHNLALSHGYTGSNFQWFFRNATSYEGELTVRTSIRVLIRIID
                     VSAYIFGYTFINNFFIYSHKRSKDLLLLVPFLIFISKTLLSGGRLDIIKILIAYVVMA
                     YIQQKRKVGWDKVISHKYMRLGFVGLIAGIPTFYYSLFLSGRSTTRTVFESISTYLGG
                     SIQHFNQYIQNPIGVAEVFGDESFVAIMNILGNLGFVNYNSTVHLEFRQLGITMGNVY
                     TFFRRPWHDFGLVGMYIFSFVVGVFFAIFYLKLRKSRAGFKLDIHTIIYSYFFYWIFL
                     SSIEQYSFTTISLFTLVFIVLVYLMAFFYWNLDFHRGKLVIKLSDTSIKSEN"
     misc_feature    9257..9388
                     /gene="wzy"
                     /locus_tag="SPC19A_0011"
                     /note="Signal peptide predicted for SPC0971 by SignalP 2.0
                     HMM (Signal peptide probability 0.988) with cleavage site
                     probability 0.615 between residues 44 and 45"
     gene            10619..12043
                     /gene="wzx"
                     /locus_tag="SPC19A_0012"
     CDS             10619..12043
                     /gene="wzx"
                     /locus_tag="SPC19A_0012"
                     /note="member of homology group 82"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33632.1"
                     /db_xref="GOA:Q4K107"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K107"
                     /translation="MNSKIKNILTNFSYVISSNLLTVLTSSLVVLIFPKLMGVTEYSY
                     WQLYIFYLTYIGFFHLGWIDGIYLKYGGLEYNNLDRKQFYSQMILFSSFLMIISLLLF
                     GLNVLAVTDSNARYIYNMTIISMIITNLRTLYVYVLQMTNRLKDSSIILLSDRVLYVL
                     LLFLFIVFGWHEYKVMILADILGRSFSLILSFWICKDIVFQPLSKFIFNIKESFDNIR
                     VGINLMLSNIASSLIIGIVRLGIQWNWNIETFGKVSLTLSVSNLLMTFINAIGLVVFP
                     LLRRTKAENLPKIYSNLRNVLMLIMFAILLIYYPLKIVLDLWLPAYQDALIFMTLIFP
                     MSVYEGKMALVINTYLKALRMERDILRVNALVMLISMGVTLVTTYLLNSLELTVVSIV
                     VLLALRSIIAELILSKKLDVSVKKDIVLEFLLTLVFISSSWYLPIGLAVIVYTIAYGL
                     YLYLKHEDIKTYLAYFKASKKTSN"
     misc_feature    10619..10738
                     /gene="wzx"
                     /locus_tag="SPC19A_0012"
                     /note="Signal peptide predicted for SPC0972 by SignalP 2.0
                     HMM (Signal peptide probability 0.731) with cleavage site
                     probability 0.397 between residues 40 and 41"
     gene            12108..13196
                     /gene="mnaA"
                     /locus_tag="SPC19A_0013"
     CDS             12108..13196
                     /gene="mnaA"
                     /locus_tag="SPC19A_0013"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33633.1"
                     /db_xref="GOA:Q4K106"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K106"
                     /translation="MKKIMLVFGTRPEAIKMCPLVNELKKHEDMETIVCVTGQHKEMV
                     SPVLDLFGVVPDYDLEIMKANQTLFSITTSILEKIKPVLEKEQPDIVLVHGDTTTTYA
                     AALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIATYHFAPTELAKENLLKE
                     GRENVYVTGNTVIDALTTTVQEDYTHTHLDLNANNRLILLTAHRRENLGEPMRHMFRA
                     VKRVLNEYEDVKVIYPIHKNPLVRETAAEIFGDTERIQIIEPLDVLDFHNFMNQSYMI
                     LTDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKLLLDDSG
                     EYKKMSQASNPYGNGDASQQIVQILRGI"
     misc_feature    12171..13187
                     /gene="mnaA"
                     /locus_tag="SPC19A_0013"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 1.9e-193"
     gene            13359..14228
                     /gene="rmlA"
                     /locus_tag="SPC19A_0014"
     CDS             13359..14228
                     /gene="rmlA"
                     /locus_tag="SPC19A_0014"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33634.1"
                     /db_xref="GOA:Q4K105"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K105"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIKDILIISTPQDLPRFKDLLLDGSEFGIKLSYAEQPSPDGLAQAFLIGEEFIGDDSV
                     ALILGDNIYHGPGLSTMLQKAAKKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEK
                     PEYPRSNYAVTGLYFYDNDVVEIAKQIKPSARGELEITDVNKAYLNRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEISYRMGYISREDVLELAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    13362..14078
                     /gene="rmlA"
                     /locus_tag="SPC19A_0014"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 7.9e-118"
     gene            14229..14825
                     /gene="rmlC"
                     /locus_tag="SPC19A_0015"
     CDS             14229..14825
                     /gene="rmlC"
                     /locus_tag="SPC19A_0015"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33635.1"
                     /db_xref="GOA:Q9ZFS9"
                     /db_xref="HSSP:1NYW"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9ZFS9"
                     /translation="MSDNFFGKTLVVRKIDAIPGLLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAAGKLQNNVSFSRKNVLRGLHAEPWDKYISVADDGKVLGSWVDLREG
                     ETFGNVYQTEIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKNHPLLKDVKPLKKEDLE"
     misc_feature    14262..14795
                     /gene="rmlC"
                     /locus_tag="SPC19A_0015"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 2.6e-16"
     gene            14835..15884
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
     CDS             14835..15884
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33636.1"
                     /db_xref="GOA:Q9RQL6"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9RQL6"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQATD
                     AYDHVTDRAGHDLRYAIDASKLREELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    14850..15806
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 5e-05"
     misc_feature    14853..15593
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 5.4e-77"
     misc_feature    14853..15689
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0045"
     misc_feature    14856..15668
                     /gene="rmlB"
                     /locus_tag="SPC19A_0016"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.4e-05"
     gene            15950..16801
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
     CDS             15950..16801
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33637.1"
                     /db_xref="GOA:Q9RQL5"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9RQL5"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    15950..16798
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.1e-148"
     misc_feature    15953..16582
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-19"
     misc_feature    15953..16594
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 9.3e-05"
     misc_feature    15956..16684
                     /gene="rmlD"
                     /locus_tag="SPC19A_0017"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.4e-08"
     gene            order(16877..17830,17841..18059)
                     /gene="tnp"
                     /locus_tag="SPC19A_0018"
                     /pseudo
     CDS             join(16877..17830,17841..18059)
                     /gene="tnp"
                     /locus_tag="SPC19A_0018"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    16883..17326
                     /gene="tnp"
                     /locus_tag="SPC19A_0018"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 7.5e-05"
                     /pseudo
     gene            18258..>18617
                     /gene="aliA"
                     /locus_tag="SPC19A_0019"
     CDS             18258..>18617
                     /gene="aliA"
                     /locus_tag="SPC19A_0019"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33639.1"
                     /db_xref="GOA:Q4JZ60"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ60"
                     /translation="MMKSSRLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKD
                     AKWYTSEGEEYAAVKAQD"
     misc_feature    18258..18344
                     /gene="aliA"
                     /locus_tag="SPC19A_0019"
                     /note="Signal peptide predicted for SPC0979 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
     misc_feature    18504..18572
                     /gene="aliA"
                     /locus_tag="SPC19A_0019"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     5675 a   3084 c   3996 g   5862 t
ORIGIN
        1 tgccaatgaa gagcaagact tgacagtaga aggaaaagtc aaatctgtct tgattgaaaa
       61 caccctagct caagaagtct ttgaaaaaca aatcttagtt ccatgggatg ctttctgtgt
      121 ggaaatgact gactagaatg agcaaacctc aagtttttga agcttgaggt tttttactat
      181 agtggattga aactagaata gtgcacctct gcttctaaaa cattgttaga aatcgatttg
      241 actgtcccga tcgatttgtc ctattcttat ttcattttgc tatacttgta gttgaggaga
      301 attaagctcc tcactagtaa actcttcata atccttttta tttttatgaa gatattgttt
      361 gaaagatgtg agtttccacg gatgggtttg tggagggata tacttgcgtc tttctttttt
      421 tgttctggtt cttgttcaaa gtttttcgaa tagagttcat gatttagtag ctcctttgtg
      481 tgatagattt tgtcagcgat attgaggtag atgtctccgt caaatgcttt tataactaat
      541 gctttcgtct ttctgatgaa atagacttct tttccttgtt cggtagggat atagtaacga
      601 ttttggaatc ggatatggtg tccactatcg acgactctct ccgccagtct agccagaatg
      661 agattccttt cagaggggtt aggaacctcc tcgaagacag agagttttgt cttgtttcca
      721 aactgttcat taaaggtttg aatgtaggaa agcaggaagg tattggcttc ttccaaggta
      781 tgaatattgt tttgttccag ttcgataggc aggcgagatt gtagtgtctg attgagtctt
      841 tcgactctcc ctttagcttg agggatagag gttgtctcaa ggagaatccc tagttggtga
      901 caggcgtatc caaactgtgt atgggtatcg tcctccattt tcttagagtt ggaggcttga
      961 taggtaaaga ccgttctctt atctgtttta atttgaaggg gaatgccgtg attggctaag
     1021 atttgttcga ggacatgata gtaagcattc aagttctctt gtttatcaaa ataagcgcct
     1081 aggatattgc cggaagcatc atcaatggct aagtgtaagt tagatgtttg ggctccaaac
     1141 taggcatgag ggctggcatc catttgaatg agttcaccag caaatttctt tctgggtcta
     1201 ctaggatgta cttttttagg gtcttcaagg aagttttcag ccgtcggtaa gattggattg
     1261 tctaggggtt gattcaggtt cagtttagct tgttttctta ctctcttctt tgtctttcta
     1321 tgggacttag gcgacaggat atttttctta tagagtattt ttctaacagt agtatcagag
     1381 agctgaattc cttcttcttc agctagcaat tcacagaaat gaaggacatt tggtttatat
     1441 gtttcatagg agaggtattt ttttaggaga cgttctttga tttcatcagg gattgcatgt
     1501 tttggttttc gatttctgtt tccgtgtctg aaggcttctt ttcctttcag ttgataggct
     1561 agtagcagac gattgatttg tctttcagaa agattgagct cgacacaggc tcgtttcttt
     1621 gttttctttc cttgggctat agcttttatc acaagatatt ttttcgtttc attcatattc
     1681 agttggatcc ttttcatatg actattctac caaatgggac attttcacgt tcgatttact
     1741 aaagacatta tcacattcga attacacaag atgcagatag tgaaaaaagg tgtagacatt
     1801 accgtaaaaa agtgatataa tcgtatgatg ttcaaggtat aggtgttaat catgagtaga
     1861 cgttttaaaa aatcacgttc acagaaagtg aagcgaagtg ttaatatcgt tttgctgact
     1921 atttatttat tgttagtttg ttttttattg ttcttaatct ttaagtacaa tatccttgct
     1981 tttagatatc ttaacctagt ggtaactgcg ttagtcctac tagttgcctt ggtagggcta
     2041 ctcttgatta tctataaaaa agctgaaaag tttactattt ttctgttggt gttctctatc
     2101 cttgtcagct ctgtgtcgct ctttgcagta cagcagtttg tgggactgac caatcgttta
     2161 aatgcgactt ctaattactc agaatattcg atcagtgttg ctgttttagc agatagtgag
     2221 attgagaatg ttacgcaact gatgagtgtg acagcaccga ctgggactga taatgaaaat
     2281 attcaaaaac tactagctga tatcaaatca agtcagaata ccgatttgac ggtcaatcag
     2341 agttcgtctt acttggcagc ttataagagt ttgattgcag gagagactaa ggccattgtc
     2401 ttaaatagtg tctttgaaaa tatcatcgaa tcggagcatc cagattacgc atcgaagata
     2461 aaaaagattt ataccaaggg attcactaaa aaagtagaag ctcctaagac gtctaaggat
     2521 cagtctttca atatctatgt tagtggaatt gacacctatg gtcctattag ttcggtgtcg
     2581 cgttcagatg tcaatatcct gatgactgtc aatcgagata ccaagaaaat tctcttgacc
     2641 acaacgccac gtgatgctta tgtaccaatc gcagatggtg ggaataatca aaaagataaa
     2701 ttgacccatg cgggcatcta tggagttgat tcgtccatcc acactttaga aaatctctat
     2761 ggagtggata tcaattacta tgtgcgattg aacttcactt ctttcttgaa attgatcgat
     2821 ttgttgggtg gggtagatgt ttataatgac caagatttta catctctaca tgggaagttc
     2881 catttcccag ttggaaatgt ccacttagat tctgagcagg ctctgggatt tgttcgtgag
     2941 cgctattccc tagcggatgg tgatcatgac cgcgggcgca atcaacaaaa ggtgattgcg
     3001 gccatccttc aaaaattaac ttcgagcgaa gcgctgaaaa attatagtag gatcattgat
     3061 agcttgcaag attctatcca aacaaacatg ccacttgaga ccatgataaa cttggtcaat
     3121 gctcagttag aaagtggtgg aacgtacaaa gtgaattcgc aagacttgaa gggtatggga
     3181 cggacggatc ttccttccta tgcgatgcca gatagtaacc tctatatgat ggaaattaac
     3241 gacagtagcc ttgcatctgt caaaactgct attcaggatg tgttggaggg cagatgaaat
     3301 gattgatatt cattcgcaca tcgtctttga tgtagatgat ggtcccaagt caagagagga
     3361 aagcaaggct ctcttggcag aatcctacag gcagggggtg cgaaccattg tctctacctc
     3421 tcaccgtcgc aagggcatgt ttgaaactcc ggaagagaag atagcagaaa actttcttca
     3481 ggttcgggaa atagctaagg aagtggcgag tgacttggtc attgcttacg gggctgaaat
     3541 ttactacaca tcagatgttt tggataagct ggaaaaaaat cggattccga ccctcaataa
     3601 tagtcgttat gccttgatag agtttagtat gaacacccct tatcgcgata ttcatagtgc
     3661 cttgagtaaa atattgatgt tgggaattac tccagtcatt gcccacattg agcgctatga
     3721 tgcacttgaa aataatgaaa aacgcgttcg agagctgatc aatatgggct gttacacgca
     3781 agtaaatagt tcacatgtcc tcaaatccaa actttttgga gaacgttata aattcatgaa
     3841 aaaaagagct cagtattttt tggagcgtga cttggttcat atcattgcaa gtgatatgca
     3901 taatgtggac agcagacctc cccatatggc agaagcatat gaccttgttt cccaaaaata
     3961 cggagaagcg aaggctcagg aactttttat agacaatcct cgaaaaattg taatggatca
     4021 actaatttag gagaaatgat gaaagaacaa aacacgatag aaatcgatgt atttcaatta
     4081 cttaaaacct tgtggaaaca caagctaata attttattag tggcacttgt gacaggggcg
     4141 ggagcttttg catatagcac ttttattgtt aagccagaat atacaagcac cacgcgtatt
     4201 tacgtagtca accgtaatca aggagataag ccgggactga cgaatcagga cttgcaggca
     4261 ggaacttatc tggtaaaaga ctaccgcgaa attatccttt cgcaagatgt attggaaaag
     4321 gtagcgacaa atttgaagtt ggatatgcca gcaaaaacgt taactagcaa agtgcaagtg
     4381 actgtaccag ccgacactcg tatcgtctca atctctgtca aggataaaca accagaggaa
     4441 gccagtcgca ttgctaattc tctacgagaa gttgctgcag aaaagatcat cgctgtaacg
     4501 cgagtatctg atgtaacgac gcttgaagaa gcgcgaccag ctatgactcc ctcttctcca
     4561 aatgttcgac gcaacacctt agttggtttt cttggaggag ccgccgtaac agtaattact
     4621 gttcttttga ttgagttgct cgatacccgt gtaaaacgtc ctgaagatgt tgaagatgta
     4681 ctgcaaatgc cacttctagg agtcgttcca gattttgata aaatgaaata ggaggaagtt
     4741 atgccaacgt tagaaatctc acaggcgaaa ttagaacttg tgaaaaaggc agaggaatat
     4801 tataatgctt tgtgcacgaa cctacagtta agtggagatg atttgaaagt attttctatc
     4861 acttctgtga aagcaggaga aggaaaaaca acgacttcca ccaatatcgc ttgggctttt
     4921 gcgcgtgcag gttacaaaac gcttctgatt gatgcagaca tgcgtaactc cgttatgtca
     4981 ggtgtcttta aatcaaggga aaggattact ggactaacag aatttctatc agggacaaca
     5041 gacctgtcac aggggctttg cgataccaat attgagaatc tctttgtgat tcaggctggc
     5101 tctgtgtcac caaatccgac agcccttctt caaagtaaga atttcactac aatgcttgaa
     5161 accttgcgta aatattttga ctatatcgtc gtagacactg cccctgtcgg tgtcgtgatt
     5221 gatgcggcta tcattatgca gaaatgtgat gcttctattt tagtgacgaa ggcaggtgaa
     5281 acaaaacgac gggatcttca aaaagcgaaa gaacagttgg aacaaactgg gaagtcgtgt
     5341 ttaggagttg tgttgaataa actcgatact tcagtagaga aatacggttc ttatgggagt
     5401 tatgggaatt acaggaaaca gaaaaaatag gttgagggat agaaatgagt gaaaaactag
     5461 caaagccttc agtagccata gtccagagtt ttcttgttat tttattgact tatctactta
     5521 gtgctgtgag agaaacggag attgtttcaa caacagctat tgtactttat atcctccact
     5581 attttgtctt ttatatcagt gattatggac ggaatttctt taaaagggga tatttgattg
     5641 aacttgtcca gacattgaaa tatatcctat tctttgcgct agcgattagt atttctaatt
     5701 ttttcttaga agatcgattt agtatttcca gaagaggcat gatttacttc ctcttattac
     5761 atgttttctt agtctatgtg ctaaacccat ttatcaagtg gtattggaag cgggcttatc
     5821 ccaactttaa aggaagtaag aagattctcc tacttacagc aacttctcgt gttgaaaagg
     5881 tactggatag actaatagaa tcagatgatg ttgttgggga gttggtagcc gtcagtgttt
     5941 tagataaacc agattttcag catgatgatt taaaggttgt agcagagggg gagatagtaa
     6001 attttgcgac tcatgaggtg gtcgatgaag tctttatcaa tcttccaagt gaaaaataca
     6061 atattggaga gcttgtctct cagtttgaaa cgatgggaat tgatgtaaca gtcaatctaa
     6121 atgctttcga ttgggcacgt aacaagcaaa tttgtgagat ggcaggacta aatgttgtga
     6181 ctttttctac aacattttat aagactagcc atgtgattgc taagcggatt attgatattg
     6241 tcggttccct ggtaggtttg atattatgtg gtctagtcag tattgtgctg gttcctttga
     6301 ttcgaaagga tgggggttct gctttttttg ctcagacgcg tataggaaaa aatggccgcc
     6361 attttacttt ttataagttt cgctctatgt gtgtggatgc tgaggagaaa aaaagagaac
     6421 tcatggaaca aaataccatg caaggtggaa tgtttaaggt ggacgatgat cctcgtatca
     6481 cgaaaattgg tcattttata cggaagacga gcttggacga gctaccacag ttttataatg
     6541 ttctaaaggg agatatgagt ttggtaggta cacgaccacc aacagtggac gagtatgagc
     6601 actatacccc agaacaaaaa cgtcgcctaa gttttaaacc tggcataaca ggtttatggc
     6661 aggtcagcgg acgaagtgaa atcaaaaatt tcgatgaagt tgtcaaatta gatgtggcct
     6721 atattgatgg ttggacaatc tggaaagata ttgaaatttt attgaagaca gttaaggttg
     6781 tattgatgaa ggatggagcg aaatagttca tatgaatgag agaattcaaa tattaggaat
     6841 tactatagat ccattaacga tgaaagaaac agtggatgct gttgaacagt atgttttaaa
     6901 gaagcaccct ttgcacttga tgggagttaa cgcggataaa attaatcagt gctatgaaga
     6961 tgagaaaatc aaaaaaatcg ttaatgaatc aggaataatt aatgccgacg gtgcttcagt
     7021 agttttagcg agtaagtttt taggaacacc agttcctgag cgagttgctg gaatagactt
     7081 gatgaaacat ttactagagt tgtctaatga aaaaggatac tcggtctact tttttggagc
     7141 aaaagaagac gttttacaag atatgttaaa aatttttgaa gaaagatatc cagctctaaa
     7201 tgttgttggc tatagaaatg gatatttttc gcctgaagat gaaaaacata ttcaggaaga
     7261 tattaaagag aaaaaaccag attttgtgtt tgtaggaatt acttctccta agaaagaata
     7321 tattatccaa tcattcatgg ataatggaat taatgctgtg tttatggggg ttggtggaag
     7381 ttttgatgta ctatcagggc atatcaaacg agctccatta tggatgcaaa atgctcacct
     7441 agagtggttg tttcgtgtgg caaatgagcc taaacgtctc tttaagcgtt attttgtagg
     7501 gaatgtttca tttataagaa aagttttaag agcgaaaagg ggatataaac tttgaaccaa
     7561 acagaaatag ttaaattgat tcagaaagtt gaattggatg ctataaaaga gtttcaaaaa
     7621 atttgtaaag agaacaatat agatttcttc cttcgtgggg ggagtgtact tggggcagtc
     7681 aaatatgatg gctttattcc atgggatgat gacatggata ttgctgtgcc tcgtgaaggc
     7741 tacgataaac ttccaggtat ctttaaggat agaattatcg caggcaaata tcaggttctt
     7801 gcttatcaat attgcgatac tttacattgc tactttcctc gcttattcct tttagaagat
     7861 gaaagaaaac gtttgggatt gccacgaaat accaatttag gtttgcattt gattgatatc
     7921 attcctttgg atggtgcccc aaatcattca tttttaagaa agctttactt cggtaaagta
     7981 tactggtatc gttttttagc aagtttagga actacctatg ttggagacca tgtggatatg
     8041 cattccgcta agcaaaaact aatcattggt ttctttaaaa agctaggatt tgcaaaacta
     8101 ttccctcaaa attatgtgta cagacgcttg gataatctct ataaaaagta tgattggaaa
     8161 aagcagaagt atgctgggac aattaatgca tctctgtttg ccaaagaagt catgccagta
     8221 gagatttggg gagaaggagt agagaagcct tttgaggatg ccttctttaa agttcccacg
     8281 gagtatgacc gctatctgaa aagactttac ggagaaaact atcttcacga agagcctagt
     8341 gatgatgaaa agaaatcgca tttaggagga caataatttg ttttgttata ttattttgca
     8401 ttacaaagtc ttagaggaaa ctatttcttg tgttaaatca ataaaagaag gcaattccaa
     8461 tacaaagcag atcgttatta ttgataattt ttctaataac ggtacgggtg aaaaactaca
     8521 agagctgtat gagtcagatt cagagattga tgtcttgatt aaccatgaaa atgctggttt
     8581 cgctcgaggt aataatgtag catatcagtt tgctaaggaa aagtacaaac ctgattttat
     8641 ggttatcatg aataatgata ttgagataga aacagaagag tttgaaaaaa tcgtgacaga
     8701 tatctatcgg aaggaaaaat tccatttgtt aggaccagat atcttttcga cgacgtatca
     8761 gcttcaccaa aacccaaaac ggttgacgca ttatacttat gaagaggtta aggctctcaa
     8821 tgaaaaattt aagaaaggga gccaagttag tctagcatta aaaattaaat gttggttgaa
     8881 gtctagtaaa gttcttcgga cagcaatcta tcaaaatagg cgtaaaaaga aatcagtaga
     8941 ctatagaaaa caggtagaaa acccaattct tcatggttcg tttattgtat attctagaga
     9001 ttttattgag aaagaggagt atgcttttaa tcccaatacc ttcttctatt atgaaacaga
     9061 gatattagat tatgaagctg agttaaaagg atataagaga atttatacac cgaagattaa
     9121 ggtcttgcac catcaaaatg ttgcaaccaa tcaagtctat acaaacttag tagaaaaaac
     9181 cttgttttca aacaaatgca actttgaatc cactagttat tttttgaagt tgatgaaaga
     9241 aaacgagggt gtgtaaatga cttatttatt tttactctgc ctgaccttat tcttattaac
     9301 tttcttctat ttttttgctt tcaatcaaga tttgatagct ccgccagttg tcatgtctgt
     9361 tatgtttctc attagttctg tatttgccct tattaatgtg caaaactgga atattgagta
     9421 tagtggttta gcttatcttt tgattattag tggcattatt gttttttcaa tgcctctctt
     9481 ggctcttaat tcgcctagtc taaataccaa gattaaagtg acggatcggc tcattgatat
     9541 ccaattctgg aaaatagctc ttactattat agttgacctc attattctat atctttatag
     9601 gagagagatt cataatcttg cacttagcca tggttatacg ggttcaaatt ttcagtggtt
     9661 ctttagaaat gctaccagtt atgaaggtga gctaacagtg cgaacttcga ttcgggtcct
     9721 cattcgtatc attgacgtat ctgcttatat ttttggatat acttttatta ataatttctt
     9781 catttatagt cataaacgct ctaaagattt actgctctta gttccattct tgatttttat
     9841 ttctaaaacc ttattatctg ggggtagatt ggatattata aaaattttaa ttgcgtatgt
     9901 tgtaatggcc tatattcagc aaaaacgaaa agttggctgg gataaggtca tctcccataa
     9961 atatatgaga cttggttttg taggcttgat agctgggatt cctacctttt actattcttt
    10021 attcttatct ggacgttcta cgactagaac tgtatttgaa agtatttcaa cctatttagg
    10081 aggttcgatt cagcatttta atcagtatat tcaaaatcct attggagtag ctgaggtttt
    10141 tggcgatgag tcatttgtag ctattatgaa tattttgggt aatcttggct ttgtcaatta
    10201 caatagtacc gttcacttag aatttcggca gttagggatt actatgggta acgtttatac
    10261 tttctttaga agaccctggc atgactttgg gttagtcggt atgtatatct tttcctttgt
    10321 tgtcggtgtg ttttttgcta ttttttattt gaaattaaga aagagccgtg ctggttttaa
    10381 attggatatt catacaatta tttactctta tttcttttat tggatttttt tatcgtccat
    10441 tgagcaatac tcgtttacaa caatcagttt gtttacactt gtatttatag tcttggttta
    10501 cctaatggct ttcttctatt ggaatttgga tttccacaga ggaaaactag taattaaact
    10561 ctctgacaca agtattaaat cggaaaactg aaaacaataa aaatagagag gatagttgat
    10621 gaatagcaaa attaaaaata tactaactaa tttctcttat gtcatttctt caaatctttt
    10681 gacagtcttg acctcttcct tggttgtctt aattttcccc aaattaatgg gggtaacaga
    10741 gtacagttac tggcaacttt atatttttta tctgacctat atcggttttt tccacttggg
    10801 ttggattgat gggatttatc ttaaatatgg tggcttagaa tataataatt tagatagaaa
    10861 acagttttat tctcagatga ttctattttc tagcttctta atgattatct ccttgctatt
    10921 gtttggttta aatgtattag ctgtaacaga ttcgaatgca cgatatattt ataatatgac
    10981 tattataagt atgataatca caaatttaag aacgctctac gtgtatgttt tgcagatgac
    11041 aaaccgcttg aaggatagtt ccatcattct actcagtgat cgcgttttat atgtgctcct
    11101 tttattcctg tttattgtat ttggttggca tgaatacaag gttatgattt tggcagatat
    11161 tctaggtcga tcattttctc tcatactttc cttctggatt tgtaaagata ttgtgtttca
    11221 gcctttgtca aaattcatct ttaatataaa agagtctttt gataatatcc gagttggtat
    11281 caatttaatg ttatccaaca tcgcaagtag tttgattatc ggtattgttc gtctaggaat
    11341 ccaatggaac tggaatatcg aaacattcgg gaaagtatct ctgaccttga gtgtttccaa
    11401 tctattgatg actttcatta atgccattgg actagtcgtc tttccgctat taagacgaac
    11461 aaaagcagaa aacttaccta agatttattc taatttaaga aacgttttga tgcttatcat
    11521 gttcgcgatt ttgctcattt actatccttt aaaaattgta ttagacctct ggttgccagc
    11581 ctatcaagat gccttgattt tcatgaccct tattttccct atgtcagtct atgaagggaa
    11641 aatggcattg gtcattaata cttacttaaa ggcattaaga atggaaagag atatccttag
    11701 agtcaatgcc ttagtaatgt tgatcagtat gggagtgacc ctggttacaa catacctgtt
    11761 aaatagtttg gagctgactg ttgtatcgat agttgttttg ctagctttga gaagtatcat
    11821 agccgaatta attctgtcta aaaaactgga tgtttcggtt aagaaggata ttgtattaga
    11881 atttcttttg acgcttgtct ttatttcttc aagttggtat ttgccgattg ggctggcagt
    11941 aattgtctac acaatagcct acggtttata tctctatttg aaacacgaag atatcaaaac
    12001 ctatttagct tactttaaag ctagtaaaaa aacatcaaat taaaaaatta tataatgatt
    12061 aagtggtaga ttctatttct accgttttag atattcggga ggtaatgatg aaaaaaatta
    12121 tgttagtatt cggtacacgt ccggaagcca tcaaaatgtg tccattagtc aatgagttga
    12181 aaaaacacga agatatggaa acaattgtgt gtgttactgg acaacacaaa gagatggtta
    12241 gtcctgtttt agatttattt ggtgttgtac cagattatga tttagaaatt atgaaggcta
    12301 accaaacctt gttctctatc acaactagta tcttggaaaa gataaaacca gttttagaga
    12361 aggaacaacc agatattgtc ctagttcacg gtgacactac gacaacttat gcagcagcct
    12421 tggcagcatt ctatttggga attaaagtag gacatgttga agctggtttg cgaacgtaca
    12481 atttacaaag tccatttcct gaagaattta acaggcaatc gacatcaatc attgcaactt
    12541 accattttgc tccaactgag ttggctaaag aaaatctctt aaaagaaggt agagagaatg
    12601 tttatgtgac tggaaatact gtcattgatg ctcttacaac tactgttcaa gaggattata
    12661 cacacactca tttagattta aacgctaaca atcgtctcat cttattgact gctcatagac
    12721 gcgaaaatct cggcgaaccg atgagacata tgtttagagc agttaaacga gtattgaatg
    12781 aatacgaaga tgttaaagtc atttatccaa ttcataagaa tcctttggta cgtgaaacag
    12841 ctgcagagat ctttggagat acagaacgga ttcaaattat tgaacctttg gatgttcttg
    12901 atttccacaa cttcatgaac caaagttata tgattttaac agattctggc ggagttcagg
    12961 aagaagcacc ttctttagga aaacctgtat tggttatgcg cgatactact gaaagacctg
    13021 aaggagtagc ggcaggaacc ttgaaattag taggaactga cgaagaaaca atttatcaaa
    13081 acttcaaact acttctagat gattctggag aatacaaaaa aatgagtcag gctagcaatc
    13141 catacggtaa tggtgatgct agtcaacaga ttgttcagat tttgcgtggg atttaagaag
    13201 attctctaaa agagtctaag aggaatccac tccacaaaca taaaactctt atgctatcat
    13261 ttatgattga gatagactca taacttaata tttttatcct aagaaaattc gttcatattc
    13321 aatatgaatg aaaaacaacg aagaaaggtt atttcattat gaaaggtatt attcttgcag
    13381 gcggctcagg tacccgcctg tacccactta ctcgggctgc gtcaaaacag ctgatgccgg
    13441 tttatgataa acctatgatt tattatccgt tgtcgacatt aatgttggct ggaattaaag
    13501 atattttgat tatctcaact cctcaagatt tgccccgttt taaggacttg ctcttggatg
    13561 gttccgaatt tgggatcaag ctttcctatg cggaacaacc tagtcccgat ggacttgctc
    13621 aggcttttct tatcggtgaa gaatttatcg gtgacgatag cgttgccttg attttaggcg
    13681 acaatatcta ccatggtcct ggtctgagca caatgcttca aaaagcagcc aagaaagaga
    13741 aaggtgcgac tgtttttggc taccaagtga aggatccaga gcgttttggt gtggttgagt
    13801 ttgatacaga catgaatgct atttctatag aagaaaaacc ggagtatcct cgctccaact
    13861 atgcagtgac aggactgtat ttctatgata atgatgttgt ggagattgct aaacagatca
    13921 aacctagtgc tcgtggcgag ttagaaatta cagacgttaa caaggcttac ctaaatcgtg
    13981 gtgacctttc tgttgagctg atggggcgtg gttttgcctg gttggatacg ggaacccatg
    14041 aaagcttgct agaagcttct cagtatattg aaacggttca gcgtatgcag aacgttcaag
    14101 tggcaaatct agaagaaatt tcctatcgta tgggctacat tagtcgtgaa gacgtgctgg
    14161 aattggctca gcctcttaag aaaaatgaat acggacaata tttgctccgt ttgattggag
    14221 aagcatagat gtcagataat ttttttggaa agacacttgt ggtacgcaag attgatgcta
    14281 taccaggact gctagagttt gatattcccg ttcatggaga caatcgtggt tggtttaagg
    14341 aaaatttcca gaaggaaaag atgctaccgc ttggttttcc tgaaagcttc tttgctgcag
    14401 ggaaactgca aaataacgtc agcttttctc gcaaaaatgt tcttcgagga ctccatgctg
    14461 aaccttggga caagtatatc tctgttgcag acgatgggaa ggttttagga tcttgggtag
    14521 atttgcgtga aggcgagacc tttggaaatg tttaccagac agagattgat gcaagcaagg
    14581 gaatctttgt tcctcgaggc gtagctaatg gcttccaagt tctatcagat acagtgtcat
    14641 atagctatct ggtcaatgat tactgggcgc ttgaactcaa acccaagtat gcctttgtga
    14701 actacgctga tccaagcctt ggtattgaat gggaaaatat tgcagaagca gaggtttcag
    14761 aagcagataa aaatcatcca ctacttaagg atgtaaaacc tttgaaaaaa gaagatttgg
    14821 aataaggaaa gaatatgact gaatacaaaa atattatcgt gacaggtgga gctggcttta
    14881 tcggttctaa ctttgtccat tatgtttacg agaactttcc agatgttcat gtgacagtcc
    14941 tagataagtt gacttatgct ggaaaccgcg cgaatattga ggaaatttta ggtaatcgtg
    15001 ttgagttagt tgttggtgac attgctgatg cggagttggt agacaagttg gctgctcaag
    15061 cagatgctat cgttcattat gcagcggaaa gccacaatga taattcgctc aatgatccat
    15121 cgccatttat tcatactaac ttcattggaa cctatactct tttagaagct gctcgtaagt
    15181 atgatattcg cttccaccat gtatcgacag atgaagttta tggggatctc cctttacgcg
    15241 aagatttgcc aggtcatgga gaagggccgg gtgagaaatt tacggctgaa accaagtaca
    15301 atccaagctc gccttactca tcaaccaagg cagcctcaga tttgattgtc aaagcctggg
    15361 tgcgttcttt tggagtcaag gcaacgattt ccaactgttc aaataactac ggtccttatc
    15421 aacatatcga aaaattcatc ccacgtcaga ttactaacat cctaagtgga attaagccaa
    15481 aactttacgg tgaaggtaag aatgttcgtg actggattca taccaatgac cattcttcag
    15541 gagtttggac aatcttgaca aaagggcaaa tcggtgaaac ctacttgatt ggggctgatg
    15601 gtgagaagaa caataaggaa gttttggaac ttatccttaa ggaaatggga caagctacgg
    15661 atgcctatga tcatgtgact gaccgtgcag gacatgacct tcgctatgcg attgatgcca
    15721 gcaagctccg tgaggagttg gggtggaaac ctgaatttac caactttgaa gctgggctca
    15781 aggcaacaat caagtggtat acagataacc aagaatggtg gaaagcagaa aaagaagctg
    15841 ttgaagccaa ttatgctaag actcaggaga ttattacagt ataaaaagca ggaaatagct
    15901 gctttttatt gctatattgg gaagagttac atattagaaa ggtctagaga tgattttaat
    15961 tacaggggca aatggccaat taggaacgga acttcgctat ttattggatg aacgtaatga
    16021 agaatacgtg gcagtagatg tggctgagat ggacattacc gatgcagaaa tggttgagaa
    16081 agtttttgaa gaggtgaaac cgactttagt ctaccactgt gcagcctaca ccgctgttga
    16141 tgcagcagag gatgaaggaa gagagttgga cttcgccatc aatgtgacgg ggacaaaaaa
    16201 tgtcgcaaaa gcatctgaaa agcatggtgc aactctagtt tatatttcta cggactatgt
    16261 ctttgatggt aagaaaccag ttggacaaga gtgggaagtt gatgaccgac cagatccaca
    16321 gacagaatat ggccgtacta agcgtatggg ggaagagtta gttgagaagc atgtgtctaa
    16381 tttctatatt atccgtactg cctgggtatt tggaaattat ggcaaaaact tcgtttttac
    16441 catgcaaaat cttgcgaaaa ctcataagac tttaacagtt gtaaatgacc agtacggtcg
    16501 tccgacttgg actcgtacct tggctgagtt catgacctac ctagctgaaa atcgtaagga
    16561 atttggttat tatcatttgt caaatgatgc gacagaagac acaacatggt atgattttgc
    16621 agttgaaatt ttgaaagata cagatgtcga agtcaagcca gtagattcca gtcaatttcc
    16681 agccaaagct aaacgtccgc taaactcaac gatgagcctg gccaaagcca aagctactgg
    16741 atttgttatt ccaacttggc aagatgcatt gcaagaattt tacaaacaag aagtgagata
    16801 agtagtagaa tgattttcta gtctaataaa agaggcagat aatgaactcc aaaggagctt
    16861 aagatgtacg attatcttgt tgttggtgct ggtctctttg gcgcatagct ttggctcagc
    16921 ttctattatc gctcacacca tccatcagaa gtttaatctg aaggtaccca attatcgcca
    16981 agaagaagat tgggctagga tgggtttacc aatcacacgt aaggaaatct ctaattggca
    17041 tatcaaggca agtcaatact atttagagtc cctttataac cttttacgag aaaagttgtt
    17101 agaacaacct cttcttcatg cggatgaaac ctcttatcgg gtgctagaga gtgatagcca
    17161 tctgacctac tattggacct ttttgtctgg gaaagctgag aatcaagcaa tcacgctgta
    17221 ccatcatgat cagcgtcgga gtggtttagt agtacaagaa ttcctaggag attattctgg
    17281 ctatgtgcat tgtgatatgt tgcggcagta acttaggact ttagtcctct agttctgcct
    17341 atgcgatagc agtccaaggt ttaggagcaa ggcgacgcta agcttggtaa actacgaacc
    17401 gctagaagct tatcgtcaac tggaagaagc tgaacttgtt ggatgttggg cgcatgtgag
    17461 aaggaagttt tttgaagcgc cccccaagca agcggataaa tcatcgttag gagctaaagg
    17521 tttagcttat tgtgatcagt tatttgcctt ggaaagagac tgggaggctt tgctagctga
    17581 tgaacgacta cagaaacgtc aagaagagct ccaaccccta atggaagatt tctttgcttg
    17641 gtgccggcgt cagtcagttt tatcgggttc aaaactagga agggcaattg aatacagcct
    17701 caagtataaa gaaacctttc agaccatttt aaaagacgga catctggtcc tttccaataa
    17761 tctagctgaa cgcgccatta aatcattggt tatgggacgg agtaaaagag tccagtggac
    17821 tcttttagcc taagctcagt ttaaaaaagt gagggtggtt attttctcaa aattttgaag
    17881 gagctaaagc aagagctatt attatgagct tattggaaac agctaaacgt catcaactaa
    17941 atagcgagaa atatctatcc tatcttctag aatgtcttcc aaacgaggaa actctcgtaa
    18001 acaaagaggt tttagaggct tatttaccat gtactaaagt tgtacaagaa aagtgcaaat
    18061 aagaaatctc cagattagga actatatatg agttctctag tctggagatt tttcaatata
    18121 cttcgttatt ggacggttac gatattcata ttttttgcaa agatgttgtt tgaaaaataa
    18181 ttttcaaaaa ttctgaaaat tctgttgaca actttctgaa aagagtctat aatggagaga
    18241 aagttttaaa ggagaaaatg atgaaaagtt caagactatt tgcccttgcg ggcgtgacat
    18301 tattggcggc gactacttta gctgcatgct ctggatcagg ttcaagcact aaaggtgaga
    18361 aaacattctc atacatttat gagacagacc ctgataacct caactatttg acaactgcta
    18421 aggctgcgac agcaaatatt accagtaacg tggttgatgg tttgctagaa aatgatcgct
    18481 acgggaactt tgtgccgtct atggctgagg attggtctgt atccaaggat ggattgactt
    18541 acacttatac tatccgtaag gatgcaaaat ggtatacttc tgaaggtgaa gaatacgcgg
    18601 cagtcaaagc tcaagac
//
