LOCUS       CR931676               21567 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain nr. 4594 (serotype 19b).
ACCESSION   CR931676
VERSION     CR931676.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21567)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 21567)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..21567
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="nr. 4594"
                     /db_xref="taxon:1313"
     gene            <1..133
                     /gene="dexB"
                     /locus_tag="SPC19B_0001"
     CDS             <1..133
                     /gene="dexB"
                     /locus_tag="SPC19B_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI33640.1"
                     /db_xref="GOA:Q4K100"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K100"
                     /translation="VNEEQDLTVEGKVKSVLIENTAAKEVLEKQVLAPWDAFCVELL"
     gene            293..461
                     /gene="aliB"
                     /locus_tag="SPC19B_0002"
                     /pseudo
     CDS             293..461
                     /gene="aliB"
                     /locus_tag="SPC19B_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(462..979)
                     /gene="tnp"
                     /locus_tag="SPC19B_0003"
                     /pseudo
     CDS             complement(join(462..521,482..979))
                     /gene="tnp"
                     /locus_tag="SPC19B_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1201..2646
                     /gene="wzg"
                     /locus_tag="SPC19B_0004"
     CDS             1201..2646
                     /gene="wzg"
                     /locus_tag="SPC19B_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33643.1"
                     /db_xref="GOA:Q4K0Z9"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Z9"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIIDSLQDSIQTNMPLETMIDLVNAQLESGGTYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1201..1317
                     /gene="wzg"
                     /locus_tag="SPC19B_0004"
                     /note="Signal peptide predicted for SPC0983 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    1405..1752
                     /gene="wzg"
                     /locus_tag="SPC19B_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 6.7e-65"
     misc_feature    1930..2373
                     /gene="wzg"
                     /locus_tag="SPC19B_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            2648..3379
                     /gene="wzh"
                     /locus_tag="SPC19B_0005"
     CDS             2648..3379
                     /gene="wzh"
                     /locus_tag="SPC19B_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33644.1"
                     /db_xref="GOA:Q4K0Z8"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Z8"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     misc_feature    2651..3259
                     /gene="wzh"
                     /locus_tag="SPC19B_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.3e-37"
     gene            3388..4080
                     /gene="wzd"
                     /locus_tag="SPC19B_0006"
     CDS             3388..4080
                     /gene="wzd"
                     /locus_tag="SPC19B_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33645.1"
                     /db_xref="GOA:Q4K0Z7"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Z7"
                     /translation="MKEQNTLEIDVLQLFRSLWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRNQEEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVISDLKLD
                     LTPKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPATSPSSPNIKRNTLIGFLAGGIGTSVIVLLLELLDTHVKRPEDIEDTLQMT
                     LLGVVPNLSKLK"
     misc_feature    3406..3822
                     /gene="wzd"
                     /locus_tag="SPC19B_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 5.3e-53"
     misc_feature    3928..4005
                     /gene="wzd"
                     /locus_tag="SPC19B_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4090..4773
                     /gene="wze"
                     /locus_tag="SPC19B_0007"
     CDS             4090..4773
                     /gene="wze"
                     /locus_tag="SPC19B_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33646.1"
                     /db_xref="GOA:Q4K0Z6"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Z6"
                     /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVISGVFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVIQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVVLNKLDISVDKYGVY
                     GFYGNYGKK"
     gene            4789..6156
                     /gene="wchA"
                     /locus_tag="SPC19B_0008"
     CDS             4789..6156
                     /gene="wchA"
                     /locus_tag="SPC19B_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33647.1"
                     /db_xref="GOA:Q4K0X4"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X4"
                     /translation="MDEKGLKIFLAVLQSIIVILSVYFLSFVRETELERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGENYDIGEIISRFETMG
                     IDVTVNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVISKRILDICGATIGLIL
                     FAIASLVLVPLIRKDGGPAIFAQTRIGKNGRYFTFYKFRSMRIDAEAIKEQLMDQNTM
                     QGGMFKMDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPE
                     QKRRLSFKPGITGLWQISGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    5572..6153
                     /gene="wchA"
                     /locus_tag="SPC19B_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 7e-146"
     gene            6160..6903
                     /gene="wchO"
                     /locus_tag="SPC19B_0009"
     CDS             6160..6903
                     /gene="wchO"
                     /locus_tag="SPC19B_0009"
                     /note="member of homology group 33"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33648.1"
                     /db_xref="GOA:Q4K0X3"
                     /db_xref="InterPro:IPR004629"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X3"
                     /translation="MRDRIQLLGLTIDLLTMNETIDIVEQYVLEKRPLHLMGVNADKI
                     NQCHTDEKIKKIVNESGIINADGASVVLASKFLGTPVPERVAGIDLMQCLLELSNKKG
                     YSVYFFGAKEEVLQDMLKVFKRDYPNLIVIGHRNGYFSEEDEQAIQEDIREKNPDFVF
                     IGITSPKKEYIIQKFMDSGVNSVFMGVGGSFDVLSGHIQRAPLWMQKSNLEWLFRVAN
                     EPKRLFKRYFVGNISFIGKVLKAKRGVKY"
     misc_feature    6322..6837
                     /gene="wchO"
                     /locus_tag="SPC19B_0009"
                     /note="HMMPfam hit to PF03808, Glycosyl transferase
                     WecB/TagA/CpsF f, score 1.6e-95"
     gene            6915..7721
                     /gene="wchP"
                     /locus_tag="SPC19B_0010"
     CDS             6915..7721
                     /gene="wchP"
                     /locus_tag="SPC19B_0010"
                     /note="member of homology group 95"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI33649.1"
                     /db_xref="GOA:Q4K0X2"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X2"
                     /translation="MIRLIQKVELDAIKEFKKICEENDIDFFLRGGSVLGAVKYDGFI
                     PWDDDMDIAVPREAYDKLPSVFKDRIIAGKYQVLTYQYCDTLHCYFPRLFLLEDERKR
                     LGLPRNTNLGLHLIDIIPLDGAPNHSVLRKIYFGKVYWYRFLASLGTTYVGDHVDMHS
                     TKQKLIIGFFKKLGFAKLFPQNSVYRRLDNLYKKYDWKKQKYAGTINASLFAKEVMPV
                     EIWGEGVEKPFEDTFFKVPTEYDRYLKRLYGENYLHEEPSDDEKKSHLGG"
     misc_feature    6972..7661
                     /gene="wchP"
                     /locus_tag="SPC19B_0010"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     9.7e-110"
     gene            7726..8598
                     /gene="wchQ"
                     /locus_tag="SPC19B_0011"
     CDS             7726..8598
                     /gene="wchQ"
                     /locus_tag="SPC19B_0011"
                     /note="member of homology group 43"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33650.1"
                     /db_xref="GOA:Q4K0X1"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X1"
                     /translation="MFCYIILHYKVLDETISCVKSIKEGNSNEKQIVIIDNFSNNGTG
                     EKLQELYESDLEIDVLINHENAGFARGNNVAYQFAKEKYNPDFMVIMNNDIEIETEDF
                     EKIVTDIYHKEKFHLLGPDIFSTTYQLHQNPKRLTHYTYEEVVALNEKFKRGSQLSLT
                     LKIKCWLKASKVLRTAIYQNRRKKGSVDHRKQVENPILHGSFIVYSRDFIEKEEYAFN
                     PNTFFYYETEILDYEAELKGYKRIYTPKIKVLHHQNVATNQVYTNLVEKTLFSNKCNF
                     ESTSYFLTLMEKNE"
     misc_feature    7732..8367
                     /gene="wchQ"
                     /locus_tag="SPC19B_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 8.2e-10"
     gene            8602..9687
                     /gene="wchR"
                     /locus_tag="SPC19B_0012"
     CDS             8602..9687
                     /gene="wchR"
                     /locus_tag="SPC19B_0012"
                     /note="member of homology group 162"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAI33651.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X0"
                     /translation="MMKKILYVTNVDWNWIKQRPQFIAENLSNFYEMLVLYRYWYNRK
                     GLTEDRNTNITNISRIYALPFVNRSPKLKQLNDKIVAWNIRRKVKAFKPEYVYLTNPM
                     QFASLVDNSEQKIIYDCMDYHVAFIENREERQRLKDLEEKLVNRANLILVSSEKLREN
                     IISDYNLEEQVNKIVVVRNGYNGKILSIPTRHKKNNQKLVLAYVGTISHWFDFDIILR
                     SLKDFDNIEYNLIGPISKADIPEHDRIHYLGSVPHEKIYQYIENADVLIMPFQINDIV
                     EAVDPVKLYEYINFKKNILTVCYKEILRFEPFVYMYSNYLDYQMNLLQLIENNNLKYD
                     SIAREDFLKSNTWEKRAELIHQLINQL"
     gene            9706..10950
                     /gene="wzy"
                     /locus_tag="SPC19B_0013"
     CDS             9706..10950
                     /gene="wzy"
                     /locus_tag="SPC19B_0013"
                     /note="member of homology group 163"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33652.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W9"
                     /translation="MKRQKFEFIEILYYFTVMLSVGMFLMFTLNLYWHRNLLTILSIA
                     LSFLMLPILIVNAKRISKSAFIYGTFLSICIIYEILRAKTLYNYSVSNIFLASRQYIW
                     IFLFFVLIYLFKNKQENMRKILDNTLNIFMFSLGIRAFTWFLYTLFQVELFPSILREF
                     GDLWYRNEFSVRIDGTPLIIIGLLISTFFYFKFGNRKYFYYLFLILMYITFVNQTRVL
                     LVSVLISIFLMFVFSRRTSRLLTSLSFVTIIIAFVYGGGLDYIKAYLNIDAGTFDLGL
                     GFRYWELKYYLGLLANDVWKLGVGILTSSNINSNFILAGPSAVKMYLDDLGFLELFVQ
                     FGVAAIFMYGYIFYKLINLILRMSNDKYRVDRAFFIALLTNLIITSISLNIFGAQRSF
                     SLAIVLALIFYYDYRLKNDIEN"
     gene            10958..11860
                     /gene="wchS"
                     /locus_tag="SPC19B_0014"
     CDS             10958..11860
                     /gene="wchS"
                     /locus_tag="SPC19B_0014"
                     /note="member of homology group 164"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33653.1"
                     /db_xref="GOA:Q4K0Y9"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y9"
                     /translation="MDKVCIVILNYNNYEETIECVQSLRSTIKSNEYDIVIVDNNSVN
                     DSVKELSKALSPIKIITSLENRGYANGNNIGIKYAEDNGYDYICILNNDTLIEVDFLE
                     SCKRELENNSFVAFVSPVLVEYKDNNLVQSTGGDIFINRGIVTLKNHGAQRDKLPSKI
                     ESDYIGGACLMFKTSILKIIGYIPESYFLFYEETEWCYRAKKLGYKNICLTQSYVYHK
                     GSVSIKAVNGLQEYLMARNRVVFVRRNINSKLKYSAFLFYLFMQQLYHCFLRRDCSKR
                     KYKYYLDGVFNRIDPSYPFIFISE"
     misc_feature    10970..11497
                     /gene="wchS"
                     /locus_tag="SPC19B_0014"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 2.4e-23"
     gene            12064..13998
                     /gene="rbsF"
                     /locus_tag="SPC19B_0015"
     CDS             12064..13998
                     /gene="rbsF"
                     /locus_tag="SPC19B_0015"
                     /note="member of homology group 49"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phosphotransferase"
                     /protein_id="CAI33654.1"
                     /db_xref="GOA:Q4K0Y8"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006439"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y8"
                     /translation="MKMFDISQIKTKTVAFDFFDTVVHRNCHPEQILYQWAKEMALEV
                     NFNISPSILYQIRKSVENNKKLGTEEMCYLDLLSGIYNEIKDKIKNTSKEEFIHRAKI
                     LELKIELQHIYLDSEIKEVLKKLKSDSKQIILVSDFYTDKELIETVLKKFEIFDYFSS
                     IYISSEKGCRKSTGNLYKLILKELGLNPIEITMIGDNCKSDYEVPRSLGLNAIYRRYI
                     DKNSTVSEKELVRLYDQILFSNSKKAPFNIFLADIVFFISELHKKMIQDDVQIALFCS
                     REGQLLKRLFDIYQDTFLRENQKICTEYFYVSRRSTLYSSFTSLENEEFEMIFRQYKK
                     ITLQNFLLNLNFSNNEITLICQDLNVKPTYVLTVDDHLLENLRKHPQFIKKFNQEKKD
                     SQLLREYIKHLTKNRNEAYLVDVGWKGTIQDSIKKALPDKRIVGYYLGLMLNVYSVEN
                     KTDKTGLLFSDYPSKSKFYDIVSRNFGFYEDIFVADHGPVLKYKKESDIIPIIDDDKK
                     HVSIYQAVKDYQEELVLGFSEILEAYKKMKFLPFEQKNLWLTMSLKKECIYIPKLQSF
                     SESLKEKVVENFGEIVTLKTTKKSIKTLLREKSDLLWVDFVYRLFGGVNFLFIPELYT
                     RVIFLLKYLDLKLRLKNYGE"
     misc_feature    12094..12717
                     /gene="rbsF"
                     /locus_tag="SPC19B_0015"
                     /note="HMMPfam hit to PF00702, haloacid dehalogenase-like
                     hydrolase, score 4.9e-15"
     gene            13988..15433
                     /gene="wzx"
                     /locus_tag="SPC19B_0016"
     CDS             13988..15433
                     /gene="wzx"
                     /locus_tag="SPC19B_0016"
                     /note="member of homology group 47"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33655.1"
                     /db_xref="GOA:Q4K0Y7"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y7"
                     /translation="MGNKSIKLNALLNIVLTLSNIIFPLITFPYISRILNPNGIGLTS
                     FFSSIGNYGILLASLGISTYGIKAVASVRDDRDKLSKVVQELMIINVAMSIITTAILL
                     FMTILITQLNREFSLLLITCGTILSSPFALNWLYSGMEEYTYITTRSVVFKILSLILI
                     FLLVKRPEDYIVFASISLFSSLSSNILNLWHSRHFINIKLYKNLQFKYHFKPMWYLFA
                     SLLAVNIYTNLDTVMLGFINGNEAVGYYSVASKVKWILLSLITSISAVLLPRLSFYIS
                     KNDTSNFIKMLKESSAVIFFIAIPLMVFFIVEAKDSILLLGGSQYLPATLAMQILMPI
                     LLISGFSNITGNQILIPMNREKYFMVAVTIGAVINLILNLLLMPKFGIIGASVATLFA
                     ELSQMTVQLHFSKEYLVSNISIKSLVNVIIATVVSIIPLIILNQLITITIPFYSLMLA
                     GFAFFSLYLVILLLLKEEVTIQLFSLLAKKK"
     misc_feature    14003..14812
                     /gene="wzx"
                     /locus_tag="SPC19B_0016"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 3.8e-80"
     gene            15497..16582
                     /gene="mnaA"
                     /locus_tag="SPC19B_0017"
     CDS             15497..16582
                     /gene="mnaA"
                     /locus_tag="SPC19B_0017"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33656.1"
                     /db_xref="GOA:O07871"
                     /db_xref="HSSP:1O6C"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:O07871"
                     /translation="MKIMLVFGTRPEAIKMCPLVNELKKQADMETVVCVTGQHKEMVS
                     PVLELFGVQPDYDLEIMKANQTLFSITTSILEKIKPVLEEEQPDIVLVHGDTTTTYAA
                     ALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIANYHFAPTELAKENLTKEG
                     RNNVYVTGNTVIDALKTTVQKDYTHPDLDLNADNRLILLTAHRRENLGEPMKHMFRAV
                     KRILNEYDDVKVIYPIHKNPLVRETAAEIFGDIERIQIIEPLDVLDFHNFMNNSYMIL
                     TDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKMLLDDSEE
                     YKKMSQASNPYGNGDASKQIVRILRGI"
     misc_feature    15557..16573
                     /gene="mnaA"
                     /locus_tag="SPC19B_0017"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 5.6e-202"
     gene            16621..17490
                     /gene="rmlA"
                     /locus_tag="SPC19B_0018"
     CDS             16621..17490
                     /gene="rmlA"
                     /locus_tag="SPC19B_0018"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33657.1"
                     /db_xref="GOA:Q4K0Y5"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y5"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLHRFQELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFISDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    16624..17340
                     /gene="rmlA"
                     /locus_tag="SPC19B_0018"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 4.9e-120"
     gene            17491..18087
                     /gene="rmlC"
                     /locus_tag="SPC19B_0019"
     CDS             17491..18087
                     /gene="rmlC"
                     /locus_tag="SPC19B_0019"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33658.1"
                     /db_xref="GOA:Q4K0Y4"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y4"
                     /translation="MTDKFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    17527..18057
                     /gene="rmlC"
                     /locus_tag="SPC19B_0019"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            18097..19146
                     /gene="rmlB"
                     /locus_tag="SPC19B_0020"
     CDS             18097..19146
                     /gene="rmlB"
                     /locus_tag="SPC19B_0020"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33659.1"
                     /db_xref="GOA:O54546"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54546"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    18112..19068
                     /gene="rmlB"
                     /locus_tag="SPC19B_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00012"
     misc_feature    18115..18855
                     /gene="rmlB"
                     /locus_tag="SPC19B_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    18118..18930
                     /gene="rmlB"
                     /locus_tag="SPC19B_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.4e-05"
     gene            19212..20063
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
     CDS             19212..20063
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33660.1"
                     /db_xref="GOA:Q9AH81"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AH81"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAKMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    19212..20060
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 4.3e-146"
     misc_feature    19215..19844
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 2e-18"
     misc_feature    19215..19856
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00011"
     misc_feature    19218..19946
                     /gene="rmlD"
                     /locus_tag="SPC19B_0021"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 3.6e-08"
     gene            order(20139..21092,21109..21324)
                     /gene="tnp"
                     /locus_tag="SPC19B_0022"
                     /pseudo
     CDS             join(20139..21092,21109..21324)
                     /gene="tnp"
                     /locus_tag="SPC19B_0022"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    20145..20588
                     /gene="tnp"
                     /locus_tag="SPC19B_0022"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 7.7e-05"
                     /pseudo
     gene            21520..>21567
                     /gene="aliA"
                     /locus_tag="SPC19B_0023"
     CDS             21520..>21567
                     /gene="aliA"
                     /locus_tag="SPC19B_0023"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33662.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K1C2"
                     /translation="MMKSSKLFALAGVTLL"
BASE COUNT     7210 a   3139 c   4260 g   6958 t
ORIGIN
        1 tgtcaatgaa gagcaagact tgacagtaga aggaaaagtc aaatctgtct tgattgaaaa
       61 cactgcggct aaagaagtac ttgaaaaaca ggtcttggct ccatgggatg ctttctgtgt
      121 ggaattacta taaatatttt ttgcagaaaa atttaaaatt gaaatcatat aaaaacaagg
      181 gaggactgta taaaagacag aaatcctttg ttttttataa ccaaggttta taaactttca
      241 ttctcgaaat tcaattaact ttacaaattc ccactattta aggagaaaga agatgaacat
      301 aaagaagcga gtccttagtg caggcctgac ttttgcatct gctttgcttt tagctgcttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttggtggaa atccaactac
      421 atttaactat ctattagact attacgctga taacatagtc aattgaaaca agaacaagac
      481 aaaagagcct cataaaaggt atggcaactt ggtaatacct tttacgaggc tttttgatat
      541 gagcccatgt tttctcaata ggattgtact caggtgagta gggaggaaga ggtaaaagtt
      601 tatacccaaa ctcttcacac aagagttcta acttacccat tctatggaat cttgcattat
      661 ccataataat aaccgatggt gtggttaatg ttggtaagag aaacttctga aaccaagctt
      721 caaaaaagtc gctcgtcatc gtctcttcgt aagtcattgg agcgattaac tcaccatttg
      781 ttagacctgc aaccaaagaa atcctctgat atcttcttcc agatacttta cctcttatta
      841 actgaccttt taatgagcga ccatattctc gataaaaata agtatcgaat cctgtttcgt
      901 caatctaaac aggtgctagg tgctttaaac tattaaaatt cttaagaaat aaggctactt
      961 tttctgggtc ttgttcataa ttagattgaa actagaatag tacacctctg cttctaaaac
     1021 attgttagaa atcgatttga ctgtcctgat cgatttgtca tgttcttatt tcattttact
     1081 atatttttgt ttcgcgggaa gtctactaag atacttaaag atgcagatag taaaaaaaat
     1141 gcggacatta ccgtaaaaaa gtgatataat cgtatgatgt tcaaggtata ggtgttaatc
     1201 atgagtagac gttttaaaaa atcacgttca cagaaagtga agcgaagtgt taatatcgtt
     1261 ttgctgacta tttatttatt gttagtttgt tttttattgt tcttaatctt taagtacaat
     1321 atccttgctt ttagatatct taacctagtg gtaactgcgt tagtcctact agttgccttg
     1381 gtagggctac tcttgattat ctataaaaaa gctgaaaagt ttactatttt tctgttggtg
     1441 ttctctatcc ttgtcagctc tgtgtcgctc tttgcagtac agcagtttgt tggactgacc
     1501 aatcgtttaa atgcgacttc taattactca gaatattcaa tcagtgtcgc tgttttagca
     1561 gatagtgata tcgaaaatgt tacgcaactg acgagtgtga cagcaccgac tgggactgat
     1621 aatgaaaata ttcaaaaact actagctgat attaagtcaa gtcagaatac cgatttgacg
     1681 gtcgaccaga gttcgtctta cttggcagct tacaagagtt tgattgcagg ggagactaag
     1741 gccattgtct taaatagtgt ctttgaaaat atcatcgagt cagagtatcc agactacgca
     1801 tcgaagataa aaaagattta taccaaggga ttcactaaaa aagtagaagc tcctaagacg
     1861 tctaagaatc agtctttcaa tatctatgtt agtggaattg acacctatgg tcctattagt
     1921 tcggtgtcgc gatcagatgt caatatcctg atgactgtca atcgagatac caagaaaatc
     1981 ctcttgacca caacaccacg tgatgcctat gtaccaatcg cagatggtgg aaataatcaa
     2041 aaagataaat taacccatgc gggcatttat ggagttgatt cgtccattca caccttagaa
     2101 aatctctatg gagtggatat caattactat gtgcgattga acttcacttc tttcttgaaa
     2161 atgattgact tattgggagg ggtagatgtt cataatgacc aagagttttc agctctacat
     2221 gggaagttcc atttcccagt agggaatgtc catctagact ctgagcaagc tctaggtttt
     2281 gtacgtgaac gctactcact agccgatgga gaccgtgacc gtggtcgcaa ccaacaaaag
     2341 gtgattgtgg ctatccttca aaaattaacg tcaaccgaag cacttaaaaa ttatagcacg
     2401 atcattgata gcttgcaaga ttctatccaa acaaatatgc cacttgagac catgatagat
     2461 ttggtcaatg ctcagttaga aagtggtgga acttacaaag tgaattcgca agacttgaaa
     2521 ggtacaggtc ggatggatct tccttcttat gcaatgccag acagtaacct ctatgtgatg
     2581 gaaatagatg atagtagttt agctgtagtt aaagcagcta tacaggatgt gatggagggt
     2641 agatgaaatg atagacatcc attcgcatat cgtttttgat gtagatgacg gccccaagtc
     2701 aagagaggaa agcaaggctc tcttggcaga atcctacagg cagggggtgc gaaccattgt
     2761 ctctacctct caccgtcgca agggcatgtt tgaaactccg gaagagaaga tagcagaaaa
     2821 ctttcttcag gttcgggaaa ttgcaaaaga agtagcagat gatttagtca ttgcttatgg
     2881 cgcagagata tactatactc tggatgctct agaaaagcta gaaaaaaaag aaattcctac
     2941 ccttaatgat agtcgttatg ctttgattga gtttagcatg catacttcct atcgtcagat
     3001 tcatacggga ttgagcaata ttttgatgtt gggaatcaca ccagtaattg ctcatattga
     3061 acggtatgat gctttagaga ataacgaaaa acgtgttcgt gaactgattg atatgggctg
     3121 ttacacgcaa gtaaatagtt cacatgtcct caaacccaaa ctttttggcg aacgttataa
     3181 attcatgaaa aaaagagctc agtatttttt ggaacgtgat ttagttcatg tagttgcaag
     3241 tgacatgcac aatttagaca gtagacctcc atatatgcaa caggcatatg atatcattgc
     3301 taagaaatat ggagcgaaaa aagcgaaaga actttttgta gataatccca gaaaaattat
     3361 aatggatcaa ttaatttagg agaaaatatg aaggaacaaa acactttgga aatcgatgta
     3421 ttgcaactat tcagatcttt atggaaaaga aagttggtca ttttattagt ggcaattata
     3481 acttcttcag ttgcttttgc ctacagtact tttgttatca aacctgagtt tactagtacg
     3541 actcggattt atgtagttaa ccgtaatcag gaagagaagt ctggtttaac caatcaagac
     3601 ttgcaggcag gaacttatct ggtaaaagac taccgtgaga ttatcctttc gcaggatgtt
     3661 ttggaggaag ttatttctga tttgaaacta gatttgacgc caaaaggttt ggctaataaa
     3721 attaaagtaa cagtaccagt tgatacccgt attgtctctg tttcagttaa tgatcgagtt
     3781 cctgaagagg caagccgtat cgctaactct ttgagagaag tagctgctca aaaaattatc
     3841 agtattactc gtgtttctga tgtgacaaca ctggaggagg caagaccggc gacatcaccg
     3901 tcttcgccaa atattaaacg caatacacta attggttttt tggcaggggg gattggaact
     3961 agtgttatag ttcttcttct tgaacttttg gacactcatg tgaaacgtcc ggaagatatc
     4021 gaagatacac tgcagatgac acttttggga gttgtaccaa acttgagtaa gttgaaatag
     4081 gagagaggaa tgccgacatt agaaatagca caaaaaaaac tggagttcat taagaaggca
     4141 gaagaatatt acaatgcctt gtgtacaaat atacagttga gcggagataa actaaaagta
     4201 atttccgtta cttctgttaa ccctggggaa ggaaaaacaa ctacttccgt aaatatagca
     4261 aggtcgtttg cgcgtgcagg ctataaaact cttttgatcg atggcgatac tcgaaattca
     4321 gttatatcag gagtttttaa atcgcgtgaa aaaattacag ggctaacaga atttttatct
     4381 gggacagctg atttatctca cggtttatgt gatacaaata ttgaaaattt atttgtaatt
     4441 caatcgggat ctgtatcacc aaaccctaca gccttgttac aaagtaaaaa ttttaatgat
     4501 atgattgaaa cattgcgtaa atattttgat tatatcattg ttgatacagc acctattgga
     4561 attgttattg atgcggcaat tatcactcaa aagtgtgatg cgtccatctt ggtaacagca
     4621 acaggtgagg tgaataaacg tgatgtccaa aaagcgaaac aacaattaga acaaacaggg
     4681 aaactgttcc taggagttgt tttaaataaa ttggatatct cggttgataa gtatggagtt
     4741 tacggtttct atggaaatta tggtaaaaaa taacttagga aagattttat ggatgaaaaa
     4801 ggattgaaaa tttttctggc agtattacag agtattattg tcattttatc ggtttatttt
     4861 cttagctttg ttagagagac agaacttgaa cgttcttcga tggttatact ataccttctc
     4921 cacttttttg tattctattt tagttcctat ggtaacaatt tttttaaaag agggtaccta
     4981 gttgagttta atagtactat aagatatatt tttttctttg caatagctat aagtgtatta
     5041 aactttttta tagcggaacg gtttagtatc tctagaagag gaatggtata cttcttaact
     5101 ttagaaggga tatccttata cttgttaaat ttcttagtaa agaaatattg gaagcatgtg
     5161 ttttttaatc taaaaaatag caagaaaatt ttactgttaa cagtaacgaa aaatatggaa
     5221 aaagttcttg ataaattgct agaatctgat gaactttcat ggaaattggt agcagtaagt
     5281 gttttggata aatctgattt tcaacatgat aaaatacctg taattgaaaa ggaaaaaatt
     5341 attgaatttg caacgcatga agttgtggat gaggtgtttg tcaatcttcc aggagagaac
     5401 tacgatattg gagaaattat ctctaggttt gagacaatgg ggatagatgt aactgtaaat
     5461 cttaaagcat ttgataagaa tttgggtcgc aataaacaaa ttcatgagat ggtaggattg
     5521 aatgtagtca ctttctctac aaatttttat aaaactagtc atgtgatttc aaagagaatt
     5581 ctcgatattt gtggtgccac tattggcctt attctttttg ctatagctag tctagtttta
     5641 gttccattga ttcgtaaaga tggcggacca gctatttttg ctcagacgcg tatagggaaa
     5701 aatggtcgat attttacctt ttataaattc cgttcgatgc ggatcgatgc tgaagctata
     5761 aaagaacaat tgatggatca aaatacgatg caaggtggta tgtttaagat ggacaatgat
     5821 cctcgtgtta caaaaattgg tcgctttatt cgtaaaacca gtttagatga gttaccccag
     5881 ttttggaatg tctttatagg agatatgagt ttggtgggaa cacgtccacc tacagtagat
     5941 gagtatgatc agtatactcc agaacagaaa cgtcgactca gctttaaacc tggtattaca
     6001 ggcttatggc agattagtgg ccgaagtaaa ataaccgatt ttgacgatgt tgtaaaatta
     6061 gatgtggctt atattgataa ttggacaatt tggaaagata ttgaaatttt gcttaaaact
     6121 gttaaagttg tatttatgag agatggagcg aagtgaggaa tgagggatag aatccaactt
     6181 ttaggtttaa caattgatct gcttacgatg aatgaaacga tagatattgt agaacaatat
     6241 gtattagaaa aaagaccact acacttgatg ggcgtgaatg ctgataaaat taatcagtgc
     6301 catacagatg agaaaatcaa aaaaatcgtt aatgagtcag gaatcattaa tgcggatgga
     6361 gcatcagttg ttcttgcaag taagttttta ggaacgcctg ttcctgaacg agtagcgggt
     6421 attgatttga tgcaatgtct tttagagttg tcaaataaaa aaggatattc agtttacttt
     6481 tttggagcaa aagaagaagt tttgcaagat atgctcaaag tatttaagag agattatcca
     6541 aatttgatag ttattggaca cagaaatggc tatttttctg aagaggatga acaagctatt
     6601 caagaagata ttcgtgaaaa gaaccctgat tttgtgttta ttggaattac gtctcctaaa
     6661 aaagaatata ttattcaaaa atttatggat agtggcgtca attcggtatt tatgggagtt
     6721 ggcggtagtt ttgatgtctt gtctggtcat atccaacgag cacctctatg gatgcaaaag
     6781 tcaaatttag agtggttatt ccgtgtagct aatgagccta aacgtctctt taaacgttat
     6841 tttgtaggga atatttcatt cataggaaaa gttttaaaag caaaaagagg tgtaaaatat
     6901 tgaaccagac agagatgatt cgcttaattc aaaaagttga attagatgct ataaaagagt
     6961 ttaaaaaaat ctgtgaagag aatgatatag attttttcct ccgcggtggt agtgtacttg
     7021 gtgcagtcaa atacgacggc tttattccat gggatgatga tatggatatc gctgtccctc
     7081 gtgaagcata cgacaaactt ccaagtgttt tcaaagatag aattatcgct gggaaatatc
     7141 aggttcttac ttatcaatac tgtgatacgt tgcattgcta ctttcctcga ctatttcttt
     7201 tagaagatga aagaaaacgt ttgggcttgc cacgaaatac caatctggga ttgcatttga
     7261 ttgatatcat tcctttagat ggagcaccaa atcattcggt tttaagaaag atttactttg
     7321 gtaaagtata ctggtatcgt tttttagcaa gtttaggaac aacttatgtt ggcgaccatg
     7381 tggatatgca ttccactaag caaaaactaa ttattggttt ctttaaaaaa ctaggatttg
     7441 caaaactatt tcctcaaaat tctgtataca gacgcttgga taatctctat aaaaagtatg
     7501 attggaaaaa gcagaagtat gctgggacta tcaatgcttc tttatttgcc aaagaagtta
     7561 tgccagtaga gatttgggga gaaggagtag agaagccttt tgaggatacc ttctttaaag
     7621 ttccaacgga gtatgatcgc tacctgaaaa gactttacgg agaaaactat cttcacgaag
     7681 agccgagtga tgatgaaaag aaatcgcatt tagggggata aaaatttgtt ttgttatatt
     7741 attttacatt acaaagtctt agatgaaact atttcttgtg ttaaatctat aaaagaaggc
     7801 aattccaatg aaaagcaaat cgttattatt gataattttt ctaataatgg tacaggtgaa
     7861 aaactacaag agctttatga atcagattta gagattgatg tattgattaa ccacgaaaat
     7921 gctggatttg ctcgaggaaa taatgtagct tatcaatttg ctaaggaaaa gtataacccc
     7981 gatttcatgg ttatcatgaa taacgatatt gagatagaaa cagaagattt tgaaaaaatc
     8041 gtgacagata tctatcacaa agaaaaattt catttgctag ggccagacat tttttcgaca
     8101 acatatcagc tacatcaaaa tcctaaacgc ctgacacatt atacttatga agaggtagtg
     8161 gctctcaatg aaaaatttaa aagagggagc caacttagtc taactttaaa aatcaaatgt
     8221 tggttgaaag ctagcaaagt tcttcgaaca gcaatctatc aaaatagacg taaaaaagga
     8281 tcagtagacc atagaaaaca ggtagaaaac ccgattcttc atggttcctt tattgtatat
     8341 tcgagagatt ttattgaaaa agaggagtat gcttttaacc ctaatacctt cttttactat
     8401 gaaacagaga tattagatta tgaagctgag ttaaaaggat acaagagaat ttatacaccg
     8461 aagattaagg ttttacacca tcaaaatgtg gcaacaaatc aggtttatac aaacttagta
     8521 gaaaaaactt tgttttcaaa caaatgcaac tttgaatcca ctagttattt tttaacttta
     8581 atggagaaaa atgaataaaa aatgatgaaa aaaattttat atgtgacaaa tgttgattgg
     8641 aattggataa aacaacgtcc acaatttatt gcagaaaact tatctaattt ttatgagatg
     8701 ctagttctgt atcgctattg gtacaataga aaaggattga ctgaggatag aaatactaac
     8761 attacaaata tatcacgtat ttatgcccta ccttttgtta ataggtcacc gaaactaaag
     8821 caactgaatg ataaaattgt tgcttggaat attcgaagaa aagttaaggc ttttaaaccg
     8881 gaatatgtat atttgacaaa tccaatgcag tttgcatctc ttgtagacaa ttcagaacaa
     8941 aaaataatat atgattgtat ggattatcat gtggctttta tagaaaatag agaagaacgt
     9001 cagcgattaa aggatttaga agagaaactg gtcaatagag ctaatttaat cttggtttcg
     9061 agtgagaaac taagagaaaa tattatttct gattataact tggaagagca ggttaataaa
     9121 atagtggttg ttagaaatgg ttataatggt aaaatcttaa gcattcctac tcggcataaa
     9181 aagaataacc aaaagcttgt acttgcatat gttggaacta tcagtcattg gtttgacttt
     9241 gatatcattt tacgaagttt aaaagatttt gataatattg aatataattt gattggtccg
     9301 attagcaaag ctgatattcc tgaacatgat agaattcatt atttaggaag tgtaccacac
     9361 gagaagattt atcagtatat tgagaatgca gatgttctga ttatgccgtt tcaaattaat
     9421 gatattgttg aagcagtgga tccagtcaag ttgtatgaat atattaattt taaaaaaaat
     9481 atacttacgg tatgttataa ggaaattctg agatttgaac catttgtata catgtattca
     9541 aattatttag attaccaaat gaatttgttg caattgattg aaaataataa tttgaaatat
     9601 gacagtatag ctagagaaga ttttttgaaa agtaatactt gggaaaaaag agcggagctg
     9661 attcatcagc tgattaacca attgtaattt tttatggaga gatgaatgaa gagacagaag
     9721 tttgaattta tagagattct atactatttt acagtgatgt tatcagtggg aatgtttctt
     9781 atgtttaccc tcaacttata ttggcacaga aacttattaa ctattttatc tattgctctc
     9841 tcatttttaa tgcttcctat actgattgtt aatgctaaaa gaatttctaa atctgctttt
     9901 atctatggta cttttttatc tatatgtatt atatatgaga tattaagagc taaaacactg
     9961 tataattaca gtgtgagtaa tatttttttg gcctctagac aatatatatg gatttttcta
    10021 ttttttgtat tgatttacct ttttaaaaac aaacaagaaa atatgagaaa aattttagat
    10081 aatacactca atatttttat gttttctctc ggaattagag catttacttg gtttttatat
    10141 acgttatttc aagttgaatt atttccatct attttaagag aattcggaga tttgtggtat
    10201 cgaaatgaat tttcagtacg aatagatgga acaccattaa ttataatagg tttgttaatt
    10261 tccacttttt tctattttaa atttggaaat aggaaatact tttattattt gttcttgata
    10321 ttaatgtata taacatttgt aaatcagaca agagtgctac tggtttctgt tttgatttca
    10381 atttttctta tgtttgtatt ttctagaaga acttctagat tgctcacctc tttaagtttt
    10441 gtaactataa ttatagcatt cgtttatgga ggtggattgg attatattaa agcatattta
    10501 aatatagatg ctggaacatt tgatctggga ttaggattta gatactggga gttgaaatac
    10561 tatctgggtt tattagctaa tgatgtatgg aaacttgggg ttggaattct aacatcaagt
    10621 aatataaata gtaattttat tttggctggg ccaagtgctg ttaagatgta tctagatgat
    10681 ttaggttttt tagagttatt cgttcaattt ggtgtagccg caatttttat gtatggttat
    10741 atattttata aattaatcaa tttaattcta agaatgtcaa atgataaata tagagttgac
    10801 cgcgcctttt ttattgcact cttaactaat ttaataatta cttcaatttc tttaaatatc
    10861 tttggagcgc agagaagttt ctcattggca attgttcttg cattaatatt ctactatgac
    10921 tataggctga aaaatgacat agaaaattag gtgtataatg gataaagtat gtatagttat
    10981 tctcaattat aataattatg aagaaacgat tgagtgtgta caaagtttga gaagtactat
    11041 aaaatcaaat gagtatgaca tcgtgattgt agataataat tcggtgaatg atagtgtcaa
    11101 agagttatcc aaggcgttat cccctattaa gattattact agtttagaaa atagaggata
    11161 tgcgaatgga aacaatattg gaataaagta tgctgaggat aatggatatg attacatttg
    11221 tatattaaac aacgatacat taattgaggt tgattttttg gaatcgtgta aacgagaact
    11281 agaaaataat tccttcgttg cctttgttag tccagtgtta gttgaatata aagataataa
    11341 cttggtacaa tctacaggtg gtgatatttt tattaatagg ggaattgtaa ctttaaaaaa
    11401 tcatggtgct cagagagaca aacttccttc taaaatcgaa agtgactata ttgggggagc
    11461 atgtttgatg ttcaaaacct ctatcttgaa aattattgga tatatacctg aaagttactt
    11521 tctattttat gaagaaactg aatggtgtta tagggctaaa aaattaggct ataagaatat
    11581 atgccttact caaagttatg tgtatcataa aggttcggtc tctataaaag cggtcaatgg
    11641 acttcaagaa tatttaatgg caagaaatag agttgtattt gttcgtagaa atataaatag
    11701 caaactaaag tattctgctt ttttgttcta tttattcatg caacaacttt atcattgctt
    11761 cttgcgaagg gattgttcta aaagaaagta taaatattat ttagatggtg tatttaatag
    11821 aattgatcca tcctatccat ttattttcat aagcgaataa gttactactt ataactgtag
    11881 atgcactaag ataattatag tagactgaat ctaaaatagt acgaaataat tgctaaaaca
    11941 tttatagaaa ttaattttac tttcctaatc gatttgttct tatcttattt caatctgcta
    12001 tagattaaat aagtgaagaa agtggtcatt ataggaacat aatttaacat agttaggtga
    12061 aacatgaaaa tgtttgatat atctcaaata aaaacaaaaa cagttgcatt tgattttttt
    12121 gatactgttg tgcataggaa ttgtcatcct gagcaaattt tgtatcagtg ggctaaggaa
    12181 atggctttgg aggtgaattt caatatatct ccttcaatat tatatcaaat cagaaaaagt
    12241 gtcgaaaaca ataaaaagtt aggcactgaa gaaatgtgtt atctagacct tttgtctgga
    12301 atatataatg aaattaaaga taagataaaa aatacatcga aagaagagtt tattcataga
    12361 gctaaaattc tagagttgaa aattgaatta caacatattt atttggattc ggaaattaaa
    12421 gaagttttaa aaaaattgaa aagtgattca aaacagatta tcttagtttc tgatttttat
    12481 actgataaag aattaataga aactgtatta aaaaagtttg aaatttttga ttatttctct
    12541 tctatctata tttcgagtga gaaaggttgc cgtaaatcca caggaaattt atataagtta
    12601 attttaaaag aattaggctt aaatcctata gaaattacca tgataggaga taattgtaaa
    12661 tctgattatg aagtgccgcg ttctctagga ttaaatgcta tttatagacg atatatagat
    12721 aaaaattcaa cagtgtcaga gaaagagttg gtaagactct atgatcaaat tttattttct
    12781 aacagtaaaa aagcaccgtt taatattttt ttagctgaca tcgtattttt tatttcggaa
    12841 ttgcataaaa agatgattca ggatgatgtt caaatagcac tcttttgctc aagagaagga
    12901 cagttattga aaagactttt tgatatatat caagatactt ttttgagaga aaatcaaaag
    12961 atttgtacag aatattttta tgtttctaga cgatcgacat tatattcttc ttttacttct
    13021 ttagagaatg aagaatttga gatgatcttt cgtcaatata aaaaaattac gttacaaaat
    13081 ttcttattaa acttgaactt ttctaataat gaaatcacat tgatttgtca agatttaaat
    13141 gtgaaaccta catatgtatt aacagtagac gatcatttat tagagaacct aagaaaacac
    13201 cctcagttta ttaagaagtt caatcaagag aaaaaagata gccaattact acgtgagtat
    13261 attaagcatt taacaaaaaa ccgaaatgag gcatatttag ttgatgtagg ttggaaagga
    13321 acgatacaag atagtatcaa aaaggctctt ccagacaaga gaatagtagg atattatcta
    13381 ggattgatgc tcaatgttta ttcagtagaa aataaaacgg ataaaactgg tttattattt
    13441 tctgattatc caagtaaatc gaaattttat gatattgtga gtagaaattt tggtttttat
    13501 gaagatattt ttgtagcaga tcatggtcca gttttgaaat ataaaaaaga gagtgatatt
    13561 atccccatta ttgacgatga taagaaacat gtgagtattt atcaggcagt taaagattat
    13621 caagaagagt tagtattagg attttcagaa attttggaag cttataagaa aatgaagttt
    13681 ctcccttttg aacaaaaaaa tctgtggcta acgatgtcgc taaaaaaaga atgtatttat
    13741 atacctaagt tacaatcatt ttctgaatct ttaaaagaaa aagttgttga aaattttggt
    13801 gagatagtaa ctcttaagac tacgaaaaaa tctataaaaa cgttattaag agagaaaagc
    13861 gatttacttt gggttgattt cgtttataga ttgtttggtg gtgtcaattt cctatttatt
    13921 ccagaattat atacaagagt tatattttta ttgaaatatt tagatttgaa attgaggttg
    13981 aaaaattatg gggaataaat ccataaagtt gaatgcatta ttaaatattg tcctgacgct
    14041 atcaaatatc attttcccat taatcacttt tccttatata tctagaatat tgaatccaaa
    14101 tggtataggt ttaacttcat tttttagttc aatagggaat tatggtattt tacttgcttc
    14161 tctgggaatt tcaacttatg gtatcaaagc agtagcaagt gttagagatg atagagataa
    14221 gttgtcaaaa gtagtacagg agttaatgat tataaacgtt gctatgtcta taataacaac
    14281 tgcaatacta ttatttatga ctatacttat aacacaattg aatagagaat tttcactcct
    14341 attgatcaca tgtgggacta ttttatcttc tcctttcgcc ttaaattggt tgtatagtgg
    14401 aatggaagaa tatacgtata ttactactag gtcagtagtg tttaaaattc tatcattaat
    14461 attgattttt ctacttgtga aaaggccaga ggattatatt gtttttgcta gtatttcatt
    14521 gttttcttct ctaagttcaa atatcttaaa tctatggcat agccgacatt tcattaatat
    14581 taaattatat aaaaatttac aatttaaata tcattttaaa ccaatgtggt atttatttgc
    14641 ctcattactt gcagtaaata tttatactaa tttagataca gtgatgctcg gttttattaa
    14701 tggtaatgag gctgtgggat actattctgt ggcatcaaag gttaagtgga ttttgctttc
    14761 tcttattaca tctattagtg cagttttgct accgagactt tcattttata ttagtaaaaa
    14821 tgacacctcg aattttataa aaatgttaaa ggagtcatct gcggttatat tttttattgc
    14881 gattccattg atggtattct ttattgtaga ggcgaaagat agtatcttat tactaggagg
    14941 aagtcagtat cttcctgcga ctttagcgat gcaaatactt atgccaattt tacttatttc
    15001 tggtttctcg aatattacag gaaatcaaat attgattcca atgaatagag aaaaatattt
    15061 tatggttgca gtaacgattg gtgctgtgat taatcttatt ttgaatctac tgttaatgcc
    15121 taagtttgga attattggtg cttctgtcgc aactcttttt gcggaattgt cgcagatgac
    15181 ggtacaatta catttttcaa aagaatattt agtatcaaat atatcgataa agagtttggt
    15241 taatgtgata attgcaacag ttgtttctat aataccacta atcattttga atcagctgat
    15301 aacgataact ataccatttt attctctaat gctagcaggt tttgctttct tttcattata
    15361 tttagtaatt ctgcttttat taaaggagga agtgacgatt caattatttt ctcttcttgc
    15421 aaagaagaag taaattggtc agaaattgaa atgtataaac aaataaataa tttaattatt
    15481 aattgaggag gaaatcatga agataatgct agtttttggt acacgtccag aagcgataaa
    15541 aatgtgtcca ttagtgaatg agttgaaaaa acaggcagat atggaaacag ttgtttgtgt
    15601 aactggtcaa cacaaggaga tggttagccc tgttttggaa ttgtttggag ttcaaccaga
    15661 ttatgattta gaaattatga aagctaatca aaccttgttt tctataacaa caagtatttt
    15721 agaaaaaatt aaacctgttt tagaagaaga acaaccagat attgttctag ttcacggtga
    15781 cactactacg acatatgcag cagctttggc agcattttat ctaggaatta aggttggtca
    15841 tgttgaagct gggttacgaa cttacaacct gcaaagtccc ttcccagaag aatttaatag
    15901 acaatcgact tctattattg caaattatca ttttgcccct acagaattag ctaaagaaaa
    15961 tctaacaaaa gagggtagaa acaatgttta tgtgacaggt aatacggtaa ttgatgcact
    16021 taaaactaca gtacaaaagg attatacaca ccctgattta gatttaaacg ctgataatcg
    16081 tctcattcta ttgactgctc atagacgtga aaatctcgga gaacctatga aacacatgtt
    16141 tagagctgtt aaacgaattt taaatgaata tgacgatgtt aaggtaattt atccaattca
    16201 taagaatcct ttggttcgtg aaacagctgc ggaaattttt ggagacatag aacgaattca
    16261 gattattgaa cctttagatg ttctggattt tcataacttt atgaataata gttacatgat
    16321 tttaactgac tcaggaggag ttcaggaaga agcgccttcg ttaggaaagc ctgtattggt
    16381 catgcgagat acgacagaaa gacctgaagg agtagctgct ggaacgttga aattggttgg
    16441 gactgatgag gagactattt atcaaaattt taagatgctt ttagacgatt ccgaagaata
    16501 taaaaaaatg agtcaagcta gtaatcctta tggaaatggt gatgctagta aacagattgt
    16561 tcgaatttta cgtggaattt gagtgtgttt agataaagta atacagaaag gtaccctact
    16621 atgaaaggta ttattctagc aggtggttcg gggactcgct tgtatccttt gactcgcgct
    16681 gcatcaaaac aactgatgcc ggtttatgat aaacccatga tttactaccc actttcaaca
    16741 ttgatgttgg ctggaattag ggatattttg attatttcca ctccacagga tttacatcga
    16801 tttcaagagc ttcttcaaga cggatctgag tttgggatca aactttctta tgcagagcaa
    16861 ccaagtccag atggtttggc acaagccttt atcattgggg aagagtttat ttctgatgat
    16921 agcgttgcgc taatcttagg tgataatatc tatcacggtt ctgggctttc caagatgcta
    16981 caaaaggcag cgagtaagga gtcgggagca actgtttttg gctaccacgt caaggatcca
    17041 gagcgctttg gtgtggttga gtttgatcag gatatgaagg ctatttctat tgaagaaaag
    17101 ccagagcaac ctcgttcaaa ctatgcagtg acaggactct atttctatga taatgatgta
    17161 gtagagattg ccaaaagtat taaaccaagt cctcgtggtg aattggaaat tacagatgtc
    17221 aacaaggctt acttggatcg tggtgatttg tctgttgagc tcatgggacg tggttttgct
    17281 tggttggata ctggcactca tgaaagttta ctagaggctt cgcagtacat cgaaacagtc
    17341 caacggatgc aaaatgttca ggtagcaaac ttagaagaaa ttgcttaccg tatgggctat
    17401 atcagtcgag aagatgtatt ggccttagcc caaccactta agaaaaatga atacggacag
    17461 tatctgctcc gtttgattgg agaagcatag atgacagata agtttttcgg taagacgctt
    17521 gcggcacgca aggttgaagc tattccaggc atgttggagt ttgatatccc cgttcatgga
    17581 gataatcgtg gctggtttaa agaaaatttc caaaaggaaa aaatgcttcc acttggattt
    17641 ccagagtctt tctttgcaga aggaaaattg caaaacaatg tatccttctc acgtaaaaat
    17701 gtccttcgag gcctccacgc agagccttgg gataagtaca tctctgtagc agatggaggg
    17761 aaagttctgg gttcttgggt tgatctacgc gagggtgaaa cctttgggaa tacctatcag
    17821 acagtgattg atgcgagtaa gggaatcttt gttcctcgag gcgtagctaa tggcttccaa
    17881 gttttatcag atacagtgtc atatagctat ctggtcaatg attactgggc gcttgaactc
    17941 aaacccaagt atgcctttgt gaactacgct gatccaagcc ttggtattga atgggaaaat
    18001 attgcagaag cagaggtttc agaagcagat aaacatcatc ccctacttaa ggacgtgaag
    18061 cctttgaaaa aagaagattt ggaataagga aagaatatga ctgaatacaa aaatattatc
    18121 gtgacaggtg gagctggctt tatcggttct aactttgtcc attatgttta cgagaacttt
    18181 ccagatgttc acgtgacagt cctagataag ttgacttatg ctggaaaccg cgcgaatatt
    18241 gaggaaattt taggtaatcg tgttgagtta gttgttggtg acattgctga tgcggagttg
    18301 gtagacaagt tggctgctca agcagatgct atcgttcatt atgcagcgga aagccacaat
    18361 gataattcgc tcaatgatcc atcgccattt attcatacta acttcattgg aacctatact
    18421 cttttagaag ctgctcgtaa gtatgatatt cgcttccacc atgtatcgac agatgaagtt
    18481 tatggggatc tccctttacg cgaagatttg ccaggtcatg gagaagggcc gggtgagaaa
    18541 tttacggctg aaaccaagta caatccaagc tcgccttact catcaaccaa ggcagcctca
    18601 gatttgattg tcaaagcctg ggtgcgttct tttggagtta aggcaacgat ttccaactgt
    18661 tcaaataact acggtcctta tcaacatatc gaaaaattca tcccacgtca gattactaac
    18721 atcctaagtg gtatcaagcc aaaactttac ggtgaaggta aaaacgttcg tgactggatt
    18781 cataccaatg accattcttc aggagtttgg acaatcttga caaaagggca aatcggtgaa
    18841 acctacttga ttggggctga tggtgagaag aacaataagg aagttttgga acttatcctt
    18901 aaggaaatgg gacaagctgc ggatgcctat gatcatgtga ctgaccgtgc aggacatgac
    18961 cttcgctatg cgattgatgc tagcaagctc cgtgatgagt tggggtggaa acctgaattt
    19021 accaactttg aagctgggct caaggcaaca atcaagtggt atacagataa ccaagaatgg
    19081 tggaaagcag aaaaagaagc tgttgaagcc aattatgcta agactcagga gattattaca
    19141 gtataaaaag caggaaatag ctgcttttta ttgctatatt gggaagagtt acatattaga
    19201 aaggtctaga gatgatttta attacagggg caaatggcca attaggaacg gaacttcgct
    19261 atttattgga tgaacgtaat gaagaatacg tggcagtaga tgtggctaag atggacatta
    19321 ccaatgaaga aatggttgag aaagtttttg aagaggtgaa accgacttta gtctaccatt
    19381 gtgcagccta caccgctgtt gatgcagcag aggatgaagg aaaagagttg gacttcgcca
    19441 tcaatgtgac ggggacaaaa aatgtcgcaa aagcatctga aaagcatggt gcaactctag
    19501 tttatatttc tacggactat gtctttgacg gtaagaaacc agttggacaa gagtgggaag
    19561 ttgatgaccg accagatcca cagacagaat atggacgcac taagcgtatg ggggaagagt
    19621 tagttgagaa gcatgtgtct aatttctata ttatccgtac tgcctgggta tttggaaatt
    19681 atggcaaaaa cttcgttttt accatgcaaa atcttgcgaa aactcataag actttaacag
    19741 ttgtaaatga tcagtacggt cgtccgactt ggactcgtac cttggctgag ttcatgacct
    19801 acctagctga aaatcgtaag gaatttggtt attatcattt gtcaaatgat gcgacagaag
    19861 atacaacatg gtatgatttt gcagttgaaa ttttgaaaga tacagatgtc gaagtcaagc
    19921 cagtagattc cagtcaattt ccagccaaag ctaaacgtcc gctaaactca acgatgagcc
    19981 tggccaaagc caaagctact ggatttgtta ttccaacttg gcaagatgca ttgcaagaat
    20041 tttacaaaca agaagtgaga taagtagtag aatgattttc tagtctaata aaagaggcag
    20101 ataatgaact ccaaaggagc ttaagatata caattatctt gttgttggtg ctgatctctt
    20161 tggcgcatag ctttggctca gtttctatta tcgctcacac catccatcag aagtttaatc
    20221 tgaaggtacc caattatcgc caagaagaag attgggctag gatgggttta ccaatcacac
    20281 gtaaggaaat ctctaattgg catatcaagg caagtcaata ctatttagag tccctttata
    20341 accttttacg agaaaagttg ttagaacaac ctcttcttca tgcggatgaa acctcttatc
    20401 gggtgctaga gagtgatagc catctgacct actattggac ctttttgtct gggaaagctg
    20461 agaatcaagc aatcacgctg taccatcatg atcagcgtcg gagtggttta gtagtacaag
    20521 aattcctagg agattattct ggctatgtgc attgtgatat gttgcggcag taacttagga
    20581 ctttagtcct ctagttctgc ctatgcgata gcagtccaag gtttaggagc aaggcgacgc
    20641 taagcttggt aaactgcgaa ccgctagaag cttatcgtca actggaagaa gctgaacttg
    20701 ttggatgttg ggcacatgtg agaaggaagt tttttgaagc gacccccaag caagcagata
    20761 aatcatcctt aggagctaaa ggtttagctt attgtgatca gttattttcc ctggaaagag
    20821 actgggaggc tttgccagct gatgaacgac tacagaaacg tcaagaacat ctccagccct
    20881 taatggaaga cttctttgct tagtgccggc gtcagtcagt tttagcaggt tcaaaactag
    20941 gaagggcaat tgaatacagc ctcaagtatg aagaaacctt taagactatt ttgaaagacg
    21001 gacatctggt cctttccaat aatctagctg aacgcgccat taaatcattg gttatgggac
    21061 ggagtaaaag aattcagtgg actcttttag cctaagctaa attttaaaaa gcgagggtgg
    21121 ttattttctc aaagttttga aggagctaaa gcaacagcta ttattatgag tttgttggaa
    21181 acagctaaac gtcatcaatt aaatagcgag aaatatctat tctatcttct agaatgtctt
    21241 ccaaacgagg aaactctcgt aaacaaagag gttttagagg cttatttacc atggactaaa
    21301 gttgtacaag aaaagtgcaa ataagaaatc tccagattag gaactatccg tgagttctct
    21361 agtctggaga tttttcaata tacttcgtta ttggacggtt acgatattca tattttttgc
    21421 aaagatgttg tttgaaaaat aattttcaaa aattctgaaa attctgttga caactttctg
    21481 aaaagagtct ataatggaga gaaagtttta aaggagaaaa tgatgaaaag ttcaaaacta
    21541 tttgcccttg cgggcgtgac attattg
//
