LOCUS       CR931677               25632 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 7588/39 (serotype 19c).
ACCESSION   CR931677
VERSION     CR931677.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 25632)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 25632)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..25632
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="7588/39"
                     /db_xref="taxon:1313"
     gene            <1..137
                     /gene="dexB"
                     /locus_tag="SPC19C_0001"
     CDS             <1..137
                     /gene="dexB"
                     /locus_tag="SPC19C_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI33663.1"
                     /db_xref="GOA:Q4K0Y0"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Y0"
                     /translation="SNEEQDLTVEGKVKSVLIENTAAKEVLEKQVLAPWDAFCVEMTD
                     "
     gene            complement(287..1678)
                     /gene="tnp"
                     /locus_tag="SPC19C_0002"
                     /pseudo
     CDS             complement(join(287..418,418..1548,1547..1678))
                     /gene="tnp"
                     /locus_tag="SPC19C_0002"
                     /note="member of homology group 17"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1202 transposase"
     misc_feature    complement(694..1194)
                     /gene="tnp"
                     /locus_tag="SPC19C_0002"
                     /note="HMMPfam hit to PF00665, Integrase core domain,
                     score 1.1e-21"
                     /pseudo
     gene            complement(1783..2736)
                     /gene="tnp"
                     /locus_tag="SPC19C_0003"
     CDS             complement(1783..2736)
                     /gene="tnp"
                     /locus_tag="SPC19C_0003"
                     /note="member of homology group 39"
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1239 transposase"
                     /protein_id="CAI33665.1"
                     /db_xref="GOA:Q4K0X9"
                     /db_xref="InterPro:IPR001584"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X9"
                     /translation="MQEHYTPKGKHLTIDNRRLIERWKNENKSNREIAGLLGKAPQTI
                     HNEVKRGTTLQQVRKGLYKKVYSADYAQTVYQFNRKRSVKKLILTKEIREKILHYHKQ
                     KFSPEMMVNKKQVKVGISTIYYWFHNGHLGLTKADMLYPRKRKGVKKQASPNFKPAGK
                     SIEERPDVINLRLENGHYEIDTVLLTKIKNYCLLVLTDRRSRHQIIRLIPNKTAESVN
                     QALTLLLGEHRILSITADNGSEFKRLSEVFPEEHIYYAHAYSSWERGSNENHNRLIRR
                     WLPKGTKKTTPKEVAFIENWINNYPKKCLDYKSPSEFLLGG"
     misc_feature    complement(1792..2229)
                     /gene="tnp"
                     /locus_tag="SPC19C_0003"
                     /note="HMMPfam hit to PF00665, Integrase core domain,
                     score 6.6e-23"
     misc_feature    complement(2590..2655)
                     /gene="tnp"
                     /locus_tag="SPC19C_0003"
                     /note="Predicted helix-turn-helix motif with score
                     1087.000, SD 2.89 at aa 28-49, sequence
                     KSNREIAGLLGKAPQTIHNEVK"
     gene            3099..4544
                     /gene="wzg"
                     /locus_tag="SPC19C_0004"
     CDS             3099..4544
                     /gene="wzg"
                     /locus_tag="SPC19C_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33666.1"
                     /db_xref="GOA:Q4K0X8"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X8"
                     /translation="MSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVLSILVSSVSLFAVQQFVGLTNR
                     LNATSSYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLM
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIIDSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    3099..3215
                     /gene="wzg"
                     /locus_tag="SPC19C_0004"
                     /note="Signal peptide predicted for SPC1006 by SignalP 2.0
                     HMM (Signal peptide probability 0.993) with cleavage site
                     probability 0.538 between residues 39 and 40"
     misc_feature    3303..3650
                     /gene="wzg"
                     /locus_tag="SPC19C_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 8.8e-63"
     misc_feature    3828..4271
                     /gene="wzg"
                     /locus_tag="SPC19C_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            4546..5277
                     /gene="wzh"
                     /locus_tag="SPC19C_0005"
     CDS             4546..5277
                     /gene="wzh"
                     /locus_tag="SPC19C_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33667.1"
                     /db_xref="GOA:Q4K0X7"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X7"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLGKKRIPTLNDS
                     RYALIEFSMNTLYRDIHNALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEKDLVHIIASDMHNLDGRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     misc_feature    4549..5157
                     /gene="wzh"
                     /locus_tag="SPC19C_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 2.4e-36"
     gene            5286..5978
                     /gene="wzd"
                     /locus_tag="SPC19C_0006"
     CDS             5286..5978
                     /gene="wzd"
                     /locus_tag="SPC19C_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33668.1"
                     /db_xref="GOA:Q4K0X6"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X6"
                     /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRNQEEKSGLTNQDLQAGSYLVKDYREIILSQDVLEEVISDLKLD
                     LTPKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPAISPSSPNIKRNTLIGFLAGGIGTSVIVLLLELLDTRVKRPEDIEDTLQMT
                     LLGVVPNLSKLK"
     misc_feature    5304..5720
                     /gene="wzd"
                     /locus_tag="SPC19C_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.1e-53"
     misc_feature    5826..5903
                     /gene="wzd"
                     /locus_tag="SPC19C_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            5988..6671
                     /gene="wze"
                     /locus_tag="SPC19C_0007"
     CDS             5988..6671
                     /gene="wze"
                     /locus_tag="SPC19C_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33669.1"
                     /db_xref="GOA:Q4K0X5"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X5"
                     /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVISGVFKSREKITGLTEFLSGTADL
                     SRGLCDTNIENLFVIQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVVLNKLDISVDKYGVY
                     GSYGNYGKK"
     gene            6687..8054
                     /gene="wchA"
                     /locus_tag="SPC19C_0008"
     CDS             6687..8054
                     /gene="wchA"
                     /locus_tag="SPC19C_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33670.1"
                     /db_xref="GOA:Q4K0X4"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X4"
                     /translation="MDEKGLKIFLAVLQSIIVILSVYFLSFVRETELERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGENYDIGEIISRFETMG
                     IDVTVNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVISKRILDICGATIGLIL
                     FAIASLVLVPLIRKDGGPAIFAQTRIGKNGRYFTFYKFRSMRIDAEAIKEQLMDQNTM
                     QGGMFKMDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPE
                     QKRRLSFKPGITGLWQISGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    7470..8051
                     /gene="wchA"
                     /locus_tag="SPC19C_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 7e-146"
     gene            8058..8801
                     /gene="wchO"
                     /locus_tag="SPC19C_0009"
     CDS             8058..8801
                     /gene="wchO"
                     /locus_tag="SPC19C_0009"
                     /note="member of homology group 33"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33671.1"
                     /db_xref="GOA:Q4K0X3"
                     /db_xref="InterPro:IPR004629"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X3"
                     /translation="MRDRIQLLGLTIDLLTMNETIDIVEQYVLEKRPLHLMGVNADKI
                     NQCHTDEKIKKIVNESGIINADGASVVLASKFLGTPVPERVAGIDLMQCLLELSNKKG
                     YSVYFFGAKEEVLQDMLKVFKRDYPNLIVIGHRNGYFSEEDEQAIQEDIREKNPDFVF
                     IGITSPKKEYIIQKFMDSGVNSVFMGVGGSFDVLSGHIQRAPLWMQKSNLEWLFRVAN
                     EPKRLFKRYFVGNISFIGKVLKAKRGVKY"
     misc_feature    8220..8735
                     /gene="wchO"
                     /locus_tag="SPC19C_0009"
                     /note="HMMPfam hit to PF03808, Glycosyl transferase
                     WecB/TagA/CpsF f, score 1.6e-95"
     gene            8813..9619
                     /gene="wchP"
                     /locus_tag="SPC19C_0010"
     CDS             8813..9619
                     /gene="wchP"
                     /locus_tag="SPC19C_0010"
                     /note="member of homology group 95"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI33672.1"
                     /db_xref="GOA:Q4K0X2"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X2"
                     /translation="MIRLIQKVELDAIKEFKKICEENDIDFFLRGGSVLGAVKYDGFI
                     PWDDDMDIAVPREAYDKLPSVFKDRIIAGKYQVLTYQYCDTLHCYFPRLFLLEDERKR
                     LGLPRNTNLGLHLIDIIPLDGAPNHSVLRKIYFGKVYWYRFLASLGTTYVGDHVDMHS
                     TKQKLIIGFFKKLGFAKLFPQNSVYRRLDNLYKKYDWKKQKYAGTINASLFAKEVMPV
                     EIWGEGVEKPFEDTFFKVPTEYDRYLKRLYGENYLHEEPSDDEKKSHLGG"
     misc_feature    8870..9559
                     /gene="wchP"
                     /locus_tag="SPC19C_0010"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     9.7e-110"
     gene            9624..10496
                     /gene="wchQ"
                     /locus_tag="SPC19C_0011"
     CDS             9624..10496
                     /gene="wchQ"
                     /locus_tag="SPC19C_0011"
                     /note="member of homology group 43"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33673.1"
                     /db_xref="GOA:Q4K0X1"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X1"
                     /translation="MFCYIILHYKVLDETISCVKSIKEGNSNEKQIVIIDNFSNNGTG
                     EKLQELYESDLEIDVLINHENAGFARGNNVAYQFAKEKYNPDFMVIMNNDIEIETEDF
                     EKIVTDIYHKEKFHLLGPDIFSTTYQLHQNPKRLTHYTYEEVVALNEKFKRGSQLSLT
                     LKIKCWLKASKVLRTAIYQNRRKKGSVDHRKQVENPILHGSFIVYSRDFIEKEEYAFN
                     PNTFFYYETEILDYEAELKGYKRIYTPKIKVLHHQNVATNQVYTNLVEKTLFSNKCNF
                     ESTSYFLTLMEKNE"
     misc_feature    9630..10265
                     /gene="wchQ"
                     /locus_tag="SPC19C_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 8.2e-10"
     gene            10500..11585
                     /gene="wchR"
                     /locus_tag="SPC19C_0012"
     CDS             10500..11585
                     /gene="wchR"
                     /locus_tag="SPC19C_0012"
                     /note="member of homology group 162"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAI33674.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0X0"
                     /translation="MMKKILYVTNVDWNWIKQRPQFIAENLSNFYEMLVLYRYWYNRK
                     GLTEDRNTNITNISRIYALPFVNRSPKLKQLNDKIVAWNIRRKVKAFKPEYVYLTNPM
                     QFASLVDNSEQKIIYDCMDYHVAFIENREERQRLKDLEEKLVNRANLILVSSEKLREN
                     IISDYNLEEQVNKIVVVRNGYNGKILSIPTRHKKNNQKLVLAYVGTISHWFDFDIILR
                     SLKDFDNIEYNLIGPISKADIPEHDRIHYLGSVPHEKIYQYIENADVLIMPFQINDIV
                     EAVDPVKLYEYINFKKNILTVCYKEILRFEPFVYMYSNYLDYQMNLLQLIENNNLKYD
                     SIAREDFLKSNTWEKRAELIHQLINQL"
     gene            11604..12848
                     /gene="wzy"
                     /locus_tag="SPC19C_0013"
     CDS             11604..12848
                     /gene="wzy"
                     /locus_tag="SPC19C_0013"
                     /note="member of homology group 163"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33675.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W9"
                     /translation="MKRQKFEFIEILYYFTVMLSVGMFLMFTLNLYWHRNLLTILSIA
                     LSFLMLPILIVNAKRISKSAFIYGTFLSICIIYEILRAKTLYNYSVSNIFLASRQYIW
                     IFLFFVLIYLFKNKQENMRKILDNTLNIFMFSLGIRAFTWFLYTLFQVELFPSILREF
                     GDLWYRNEFSVRIDGTPLIIIGLLISTFFYFKFGNRKYFYYLFLILMYITFVNQTRVL
                     LVSVLISIFLMFVFSRRTSRLLTSLSFVTIIIAFVYGGGLDYIKAYLNIDAGTFDLGL
                     GFRYWELKYYLGLLANDVWKLGVGILTSSNINSNFILAGPSAVKMYLDDLGFLELFVQ
                     FGVAAIFMYGYIFYKLINLILRMSNDKYRVDRAFFIALLTNLIITSISLNIFGAQRSF
                     SLAIVLALIFYYDYRLKNDIEN"
     gene            12856..13758
                     /gene="wchS"
                     /locus_tag="SPC19C_0014"
     CDS             12856..13758
                     /gene="wchS"
                     /locus_tag="SPC19C_0014"
                     /note="member of homology group 164"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33676.1"
                     /db_xref="GOA:Q4K0W8"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W8"
                     /translation="MDKVCIVILNYNNYEETIECVQSLRSTIKSNEYDIVIVDNNSVN
                     DSVKELSKALSPIKIITSLENRGYANGNNIGIKYAEDNGYDYICILNNDTLIEVDFLE
                     SCKRELENNSFVAFVSPVLVEYKDNNLVQSTGGDIFINRGIVTLKNHGAQRDKLPSKI
                     ESDYIGGACLMFKTSILKIIGYIPESYFLFYEETEWCYRAKKLGYKNICLTQSYVYHK
                     GSVSIKAVNGLQEYLMARNRVVFVRRNVNSKLKYSAFLFYLFMQQLYHCFLRRDCFKR
                     KYKYYLDGVFNRIDPSYPFIFISE"
     misc_feature    12868..13395
                     /gene="wchS"
                     /locus_tag="SPC19C_0014"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 2.4e-23"
     gene            13962..15896
                     /gene="rbsF"
                     /locus_tag="SPC19C_0015"
     CDS             13962..15896
                     /gene="rbsF"
                     /locus_tag="SPC19C_0015"
                     /note="member of homology group 49"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phosphotransferase"
                     /protein_id="CAI33677.1"
                     /db_xref="GOA:Q4K0W7"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006439"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W7"
                     /translation="MKVFDISQIKTKTVAFDFFDTIVHRNCHPEQILYQWAKEMALEV
                     NFNISPSILYQIRKSVENNKKLGTEEMCYLDLLSGIYNEIKDKIKNTSKEEFIHRAKI
                     LELKIELQHIYLDSEIKEVLKKLKSDSKQIILVSDFYTDKELIETVLKKFEVFDYFSS
                     IYISSEKGCRKSTGNLYKLILKELGLNPKEITMIGDNYKSDYEVPRSLGLNAIYRQYI
                     DKNTIVAEKELVRLYNQILFSNSKKAPFNIFLADIVFFISKLHKKMIQDDVQIALFCS
                     REGQLLKILFDIYQNTFFGKNQKICTEYFYVSRRSTLYSSFTSLDNEEFETIFRQYKK
                     ITLQNFLLNLNFSDNEIILICQDLKEKPTYVLTVDDHLLEKLKKHPQFITKFNKEKKD
                     SQLLRDYIEYLTKNQNEVYLVDVGWKGTIQDNIKKALPDKRIVGYYLGLILNAYSVEN
                     KMDKTGLLFSDYPSKSKFYDIVSRNFGFYEDIFVADHGPVLKYKKESDIIPIIDDDKK
                     HVSIYQAVKDYQEELVLGFSEILEAYKKMKFLPFEQKNLWLMMSLKKECIYIPKLQSF
                     SESLKEKVVENFGEIVTLKTTKKSIKTLLRKKSDLLWVDFVYRLFGGVNFLFIPELYT
                     RVIFLLKYLDLKLRLKNYGE"
     misc_feature    13992..14615
                     /gene="rbsF"
                     /locus_tag="SPC19C_0015"
                     /note="HMMPfam hit to PF00702, haloacid dehalogenase-like
                     hydrolase, score 7.9e-16"
     gene            15886..17331
                     /gene="wzx"
                     /locus_tag="SPC19C_0016"
     CDS             15886..17331
                     /gene="wzx"
                     /locus_tag="SPC19C_0016"
                     /note="member of homology group 47"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33678.1"
                     /db_xref="GOA:Q4K0W6"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W6"
                     /translation="MGNKSIKLNALLNIVLTLSNIIFPLITFPYISRILNPNGIGLTS
                     FFSSIGNYGILLASLGISTYGIKAVASVRDDRDKLSKVVQELMIINVAMSIITTAILL
                     FMTIFITQLNREFSLLLITCGTILSSPFALNWLYSGMEEYTYITTRSVVFKILSLILI
                     FLLVKRPEDYIVFASISLFSSLSSNILNLWHSRHFINIKLYKNLQFKYHFKPMWYLFA
                     SLLAVNIYTNLDTVMLGFINGNEAVGYYSVASKVKWILLSLITSISAVLLPRLSFYIS
                     KNDTSNFIKMLKESSAVIFFIAIPLMVFFIVEAKDSILLLGGSQYLPATLAMQILMPI
                     LLISGFSNITGNQILIPMNREKYFMVAVTIGAVINLILNLLLMPKFGIIGASVATLFA
                     ELSQMTVQLHFSKEYLVSNISIKSLVNVIIATVVSTIPLIILNQLITITIPFYSLMLA
                     GFAFFSLYLVILLLLKEEVTIQLFSLLAKKK"
     misc_feature    15901..16710
                     /gene="wzx"
                     /locus_tag="SPC19C_0016"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 3.1e-80"
     gene            17395..18480
                     /gene="mnaA"
                     /locus_tag="SPC19C_0017"
     CDS             17395..18480
                     /gene="mnaA"
                     /locus_tag="SPC19C_0017"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33679.1"
                     /db_xref="GOA:Q9Z636"
                     /db_xref="HSSP:1O6C"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q9Z636"
                     /translation="MKIMLVFGTRPEAIKMCPLVNELKKQADMETVVCVTGQHKEMVS
                     PVLELFGVQPDYDLEIMKANQTLFSITTSILEKIKPVLEEEQPDIVLVHGDTTTTYAA
                     ALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIANYHFAPTELAKENLLKEG
                     RENVYVTGNTVIDALTTTVQKDYTHPDLDLNVNTRLILLTAHRRENLGEPMKHMFRAV
                     KRVLNEYDDVKVIYPIHKNPLVRETATEIFGDTERIQIIEPLDVLDFHNFMNHSYMIL
                     TDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKMLLDDSEE
                     YKKMSQASNPYGKGDASKQIVHILSGI"
     misc_feature    17455..18471
                     /gene="mnaA"
                     /locus_tag="SPC19C_0017"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 9.9e-198"
     gene            18831..19940
                     /gene="wchU"
                     /locus_tag="SPC19C_0018"
     CDS             18831..19940
                     /gene="wchU"
                     /locus_tag="SPC19C_0018"
                     /note="member of homology group 237"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33680.1"
                     /db_xref="GOA:Q9Z635"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q9Z635"
                     /translation="MKIVIPRIIHNKEQLTWDWSGTITNIKKFLGKYEIVEEQNIFYT
                     FRMNVHKVLVRLGIKKSDMSMTYIKYAENQVHLSPEDVCLTFDEFPLSFPDNPVYIYQ
                     DLNLHYLIESSQNNSQSFKYSGFQNVPADILDRRMRKQEIFYNQATGIFTMSKWFSDY
                     LIAQQGLPVEKVHYVGAGTNMNNLFLDHSHKERNKFLFIGKDFFRKGGDLVYNAFVYL
                     QNNLMPEAELYIIGPSDVPMEFNNPNVYFLGNLSADKVQYFYNLCDVFVLPSRFEAFG
                     IVFVEALCYGLPCIGRDLMEMPNLIQNNETGLLLPTEEENPQVLADVMYNLIKDESFF
                     KNVQTKQDYYKAEYSWDTVAKRMISIMKQDMNNNL"
     misc_feature    19371..19850
                     /gene="wchU"
                     /locus_tag="SPC19C_0018"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 2.8e-22"
     gene            20399..20506
                     /gene="HG264"
                     /locus_tag="SPC19C_0019"
                     /pseudo
     CDS             20399..20506
                     /gene="HG264"
                     /locus_tag="SPC19C_0019"
                     /note="member of homology group 264"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein (fragment)"
                     /db_xref="PSEUDO:CAI33681.1"
     gene            20574..21443
                     /gene="rmlA"
                     /locus_tag="SPC19C_0020"
     CDS             20574..21443
                     /gene="rmlA"
                     /locus_tag="SPC19C_0020"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33682.1"
                     /db_xref="GOA:Q4K0W3"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W3"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLPRFKELLQDGSEFGIQLSYAEQPSPDGLAQAFIIGEEFIGDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    20577..21293
                     /gene="rmlA"
                     /locus_tag="SPC19C_0020"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 8e-121"
     gene            21444..22037
                     /gene="rmlC"
                     /locus_tag="SPC19C_0021"
     CDS             21444..22037
                     /gene="rmlC"
                     /locus_tag="SPC19C_0021"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33683.1"
                     /db_xref="GOA:Q4K0W2"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W2"
                     /translation="MTDKFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
     misc_feature    21480..22010
                     /gene="rmlC"
                     /locus_tag="SPC19C_0021"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            22050..23099
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
     CDS             22050..23099
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33684.1"
                     /db_xref="GOA:Q4K0W1"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0W1"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPGVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLATQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    22065..23021
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00013"
     misc_feature    22068..22808
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 7.8e-76"
     misc_feature    22068..22865
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0053"
     misc_feature    22071..22883
                     /gene="rmlB"
                     /locus_tag="SPC19C_0022"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 2.1e-05"
     gene            23165..24016
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
     CDS             23165..24016
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33685.1"
                     /db_xref="GOA:Q9AH81"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AH81"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAKMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    23165..24013
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 4.3e-146"
     misc_feature    23168..23797
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 2e-18"
     misc_feature    23168..23809
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00011"
     misc_feature    23171..23899
                     /gene="rmlD"
                     /locus_tag="SPC19C_0023"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 3.6e-08"
     gene            order(24079..24159,24163..25162)
                     /gene="glf"
                     /locus_tag="SPC19C_0024"
     CDS             join(24079..24159,24163..24582,24549..24683,24659..25162)
                     /gene="glf"
                     /locus_tag="SPC19C_0024"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI33686.1"
                     /db_xref="GOA:Q4K0V9"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V9"
                     /translation="MYDYLVVGAVFAHEAVLKGKKVKVIEKNHIAGNIYTREEEGIQV
                     HQYGAHIFHTSDKEIWDYVNQFAEFNRYINSPVANYKGEIYNLPFNMNTFNKLWGVVT
                     PAEAQAKIDEQRAILNGKTPENLEEQAISLVATDIYEKLIKDYTEKQWGKPTTELPSF
                     IIVCQYATSILYYCLPVRLTYDNNYFNDTYQGIPIGRYTQIVEKCWIMKILMMLDHEN
                     IDVETNVDFFVNKEQYLKDFPKIVFTGMIDEFFDYKLGELEYRSLRFENETLDMENYQ
                     GNAVVNYTDAETPYTRIIEHKHFEFGSQAKTIITKEHSKTWEKGDEPYYPVNNDRNNH
                     LYKSYKKLADEQGNVIFGGRLGHYRYYDIHQVIGAALQCVRNELN"
     misc_feature    join(24499..24549,24582..24659,24683..25102)
                     /gene="glf"
                     /locus_tag="SPC19C_0024"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 1.5e-95"
     gene            25480..>25632
                     /gene="aliA"
                     /locus_tag="SPC19C_0025"
     CDS             25480..>25632
                     /gene="aliA"
                     /locus_tag="SPC19C_0025"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33687.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V8"
                     /translation="MMKSSRLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYL"
     misc_feature    25480..25566
                     /gene="aliA"
                     /locus_tag="SPC19C_0025"
                     /note="Signal peptide predicted for SPC1027 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
BASE COUNT     8413 a   3746 c   5015 g   8458 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acactgcggc taaagaagta cttgaaaaac aggtcttggc cccatgggat gctttctgtg
      121 tggaaatgac tgactagaat gagcaaacct caagcttttg aagcttgagg ttttttacta
      181 tagtagattg aaactggaat agtacacctc tacttctaaa acattgttag aaatcgattt
      241 gattgtcctg atcgttttgt cctattctta tttcatttta ctatgcttgt agttgaggag
      301 aattaagctc ctcactagta aactcttcat aatccttttt atttttatga agatattgtt
      361 tgaaagatgt gagtttccac ggataggttt gtggagggat atacttgcgt ctttcttttt
      421 ttgttctggt tcttgttcaa agtttttcga atagagttca tgatctagta gctcctttgt
      481 gcgatagatt ttgtcagcga tattgaggta gatatctccg tcaaatgctt ttataactaa
      541 tgctttcgtc tttctgatga aatagacttc tttttcttgt tcggtaggga tatagtaacg
      601 attttggaat cggatatggt gtccactatc ggcgactctc tccgccagtc tagccagaat
      661 gagattcctt tcagaggggt taggaacctc ctcgaagaca gagagttttg tcttgtttcc
      721 aaactgttca ttaaaggttt gaatgtagga aagcaggaag gtattggctt cttccaaggt
      781 atgaatattg ttttgttcca gttcgatagg taggcgagat tgtagtgtct gattgagtct
      841 ttcgactctc cctttagctt gagggataga ggttgtctca aggagaatcc ctagttggtg
      901 acaggcgcat ccaaactgtg tatgggtatc gtcctccatt ttcttagagt tggaggcttg
      961 ataggtaaag accgttctct tatctgtttt aatttgaagg ggaatgccgt gattggctaa
     1021 gatttgttcg aggacatgat agtaagcatt caagttctct tgtttatcaa aataagcgcc
     1081 taggatattg ccagaagcat catcaatggc taagtgtaag ttagatgttt gggctccaaa
     1141 ctaggcatga ggactggcat ccatttgaat gagttcacca gcaaatttct ttctgggtct
     1201 actaggatgt acttttttag ggtcttcaag gaagttttca gccgtcggta agattggatt
     1261 gtctaggggt tgattcaggt tcagtttagc ttgttttctt actctcttct ttgtctttct
     1321 atgggactta ggcgacagga tatttttctt atagagtatt tttctaacag tagtatcaga
     1381 gagctgaatt ccttcttctt cagctagcaa ttcacagaaa tgaaggacat ttggtttata
     1441 tgtttcatag gagaggtatt tttttaggag acgttctttg atttcatcag ggattgcatg
     1501 ttttggtttt cgatttctgt ttccgtgtct gaaggcttct ttgtcctttc agttgatagg
     1561 ctagtagcag acgattgatt tgtctttcag aaagattgag ctcgacacag gctcgtttct
     1621 ttgttttctt tccttgggct atagctttta tcacaagata ttttttcgtt tcattcatat
     1681 tcagttggat ccttttcata tgactattct accaaatggg acattttcac gttcgattta
     1741 ctaaagacat tatcacattc gaacccaaat ttcaagttga agttagccac ccaaaagaaa
     1801 ttcacttggc gacttgtagt ccaagcattt tttagggtag ttgttaatcc aattttcgat
     1861 aaaagctact tctttcggag tcgttttctt ggttccttta ggtaaccatc tccgaattaa
     1921 tcgattatga ttttcatttg aacctctctc ccatgaagag taagcatgtg cgtagtagat
     1981 atgttcctca ggaaatacct cagacaatcg tttgaactcc gaaccattat ctgcagtaat
     2041 ggacagaata cgatgctccc ctaatagtaa cgtaagcgcc tgattgacag attcagcagt
     2101 tttatttgga attaacctta taatttggtg tctgctccgc cggtcggtta agactaacag
     2161 gcaataattt tttatcttag tcagtaggac ggtatcaatt tcataatgac cattttccaa
     2221 gcgaagatta ataacgtcag gacgttcttc gatagattta cctgccggct taaagttcgg
     2281 actagcttgc ttcttgacac ctttcctttt tctgggataa agcatgtcgg ccttcgttaa
     2341 tcctaaatga ccattatgaa accagtagta gatggttgaa ataccaactt tcacttgctt
     2401 cttgttaacc atcatttcag gcgaaaattt ttgcttatga tagtgtaaga tcttctctct
     2461 gatttccttt gttaaaatta actttttcac cgaccgtttt cgattgaatt ggtaaacagt
     2521 ttgtgcgtaa tcggcagaat agaccttttt gtatagccct tttctcactt gttgtaaagt
     2581 tgtacctctt ttgacttcat tatgaatcgt ttgaggcgcc tttcctaaca agcctgcaat
     2641 ttcacgattg gacttatttt cattcttcca ccgctcaatc aagcgacggt tatctattgt
     2701 caaatgtttc ccttttgggg tataatgttc ttgcatctct gtgcctttcc ttgtgtttgt
     2761 ggtgaacaac aagtatagca cagaggtgtt ttcttatacc ttaaatcaca tttcatttga
     2821 caacaggaac ccttgaacct gttttttcag ctaaaccaag gctatgatta gccttggcca
     2881 cctagcctaa cagtttcaaa cctgttatca aatgaaatca tcaacttact caaacatagt
     2941 gaaacatcta attcttgact aaggtaaggt ggctaacttc attatagaac tttcatatca
     3001 cattcgaatt acacaagatg cagatagtga aaaaagatgt agacattacc gtaaaaaagt
     3061 gatataatcg tatgatgttc aatgtatagg tgttaatcat gagtagacgt tttaaaaaat
     3121 caggttcaca gaaagtgaag cgaagtgtta atatcgtttt gctgactatt tatttattgt
     3181 tagtttgttt tttattgttc ttaatcttta agtacaatat ccttgctttt agatatctta
     3241 atctcgtggt aactgcgtta gtcctactag ttgccttggt agggctactc ttgattatct
     3301 ataaaaaagc tgaaaagttt actatttttc tgttggtgct ctctatcctt gtcagctctg
     3361 tgtcgctctt tgcagtacag cagtttgttg gactgaccaa tcgtttaaat gcgacttcta
     3421 gttactcaga atattcaatc agtgtcgctg ttttagcaga tagtgagatc gaaaatgtta
     3481 cgcaactgac gagtgtgaca gcaccgactg ggactgataa tgaaaatatt caaaaactac
     3541 tagctgatat caagtcaagt cagaataccg atttgatggt caaccagagt tcgtcttact
     3601 tggcagctta caagagtttg attgcagggg agactaaggc cattgtccta aatagtgtct
     3661 ttgaaaatat catcgagtca gagtatccag actacgcatc gaagataaaa aagatttata
     3721 ccaagggatt cactaaaaaa gtagaagctc ctaagacgtc taagaatcag tctttcaata
     3781 tctatgttag tggaattgac acctatggtc ctattagttc ggtgtcgcga tcagatgtca
     3841 atatcctgat gactgtcaat cgagatacca agaaaatcct cttgaccaca acaccacgtg
     3901 atgcctatgt accaatcgca gatggtggaa ataatcaaaa agataaatta acccatgcgg
     3961 gcatttatgg agttgattcg tccattcaca ccttagaaaa tctctatgga gtggatatca
     4021 attactatgt gcgattgaac ttcacttctt tcttgaaaat gattgactta ttgggagggg
     4081 tagatgttca taatgaccaa gagttttcag ctctacatgg gaagttccat ttcccagtag
     4141 ggaatgtcca tctagactct gagcaagctc taggttttgt acgtgaacgc tactcactag
     4201 ccgatggaga ccgtgaccgt ggtcgcaacc aacaaaaggt gattgtggct atccttcaaa
     4261 aattaacgtc aaccgaagca ctgaaaaatt atagtacgat cattgatagc ttgcaagatt
     4321 ctatccaaac aaatatgcca cttgagacca tgataaattt ggtcaatgct cagttagaaa
     4381 gtggagggaa ttataaagta aattctcaag atttaaaagg tacaggtcgg atggatcttc
     4441 cttcttatgc aatgccagac agtaacctct atgtgatgga aatagatgat agtagtttag
     4501 ctgtagttaa agcagctata caggatgtga tggagggtag atgaaatgat agacatccat
     4561 tcgcatatcg tttttgatgt agatgacggt cccaagtcaa gagaggaaag caaggctctc
     4621 ttggcagaat cctacaggca gggggtgcga accattgtct ctacctctca ccgtcgcaag
     4681 ggcatgtttg aaactccgga agagaagata gcagaaaact ttcttcaggt tcgggaaata
     4741 gctaaggaag tggcgagtga cttagtcatt gcttacggag ctgaaattta ctacacacca
     4801 gatgttctgg ataagctggg aaaaaagcgg attccgaccc tcaatgatag tcgttatgcc
     4861 ttgatagagt ttagtatgaa cactctttat cgcgatattc ataacgcctt gagcaagatc
     4921 ttgatgttgg gaattactcc agtcattgcc cacatcgaac gctatgatgc tcttgaaaat
     4981 aatgaaaaac gcgttcggga actgatcgat atgggctgtt acacgcaagt aaatagttca
     5041 catgtcctca aacccaaact ttttggcgaa cgttataaat tcatgaaaaa aagagctcag
     5101 tattttttag agaaggattt ggttcatatc attgcaagtg atatgcacaa tctagacggt
     5161 agacctccat atatgcaaca ggcatatgat atcattgcta agaaatatgg agcgaaaaaa
     5221 gcgaaagaac tttttgtaga taatcccaga aaaattataa tggatcaatt aatttaggag
     5281 aaaatatgaa ggaacaaaac actttggaaa tcgatgtatt gcaactattc agagctttat
     5341 ggaaaagaaa gttggtcatt ttattagtgg caattataac ttcttcagtt gcttttgcct
     5401 acagtacttt tgttatcaaa cctgagttta ctagtacgac tcggatttat gtagttaacc
     5461 gtaatcagga agagaagtct ggtttaacca atcaagactt gcaggcagga tcatacttgg
     5521 ttaaagacta tcgtgaaatt atcctatcgc aggatgtttt ggaggaagtt atttctgatt
     5581 tgaaactaga tttgacgcca aaaggtttgg ctaataaaat taaagtaaca gtaccagttg
     5641 atacccgtat tgtctctgtt tcagttaatg atcgagttcc tgaagaggca agccgtatcg
     5701 ctaactcttt gagagaagta gctgctcaaa aaattatcag tattactcgt gtttctgatg
     5761 tgacaacact ggaggaggca agaccggcga tatcaccgtc ttcgccaaat attaaacgca
     5821 atacactaat tggttttttg gcagggggga ttggaactag tgttatagtt cttcttcttg
     5881 aacttttgga cactcgtgtg aaacgtccgg aagatatcga agatacactg cagatgacac
     5941 ttttgggagt tgtaccaaac ttgagtaagt tgaaatagga gagaggaatg ccgacattag
     6001 aaatagcaca aaaaaaactg gagttcatta agaaggcaga agaatattac aatgccttgt
     6061 gtacaaatat acagttgagc ggagataaac taaaagtaat ttccgttact tctgttaacc
     6121 ctggggaagg aaaaacaact acttccgtaa atatagcaag gtcgtttgcg cgtgcaggtt
     6181 ataaaactct tttgatcgat ggcgatactc gaaattcagt tatatcagga gtttttaaat
     6241 cgcgtgaaaa aattacaggg ctaacagaat ttttatctgg gacagctgat ttatctcgcg
     6301 gtttatgtga tacaaatatt gaaaatttat ttgtaattca atcgggatct gtatcaccaa
     6361 accctacagc cttgttacaa agtaaaaatt ttaatgatat gattgaaaca ttgcgtaaat
     6421 attttgatta tatcattgtt gatacagcac ctattggaat tgttattgat gcggcaatta
     6481 tcactcaaaa gtgtgatgcg tccatcttgg taacagcaac aggtgaggtg aataaacgtg
     6541 atgtccaaaa agcgaaacaa caattagaac aaacagggaa actgttccta ggagttgttt
     6601 taaataaatt ggatatctcg gttgataagt atggagttta cggttcctat ggaaattatg
     6661 gtaaaaaata acttaggaaa gattttatgg atgaaaaagg attgaaaatt tttctggcag
     6721 tattacagag tattattgtc attttatcgg tttattttct tagctttgtt agagagacag
     6781 aacttgaacg ttcttcgatg gttatactat accttctcca cttttttgta ttctatttta
     6841 gttcctatgg taacaatttt tttaaaagag ggtacctagt tgagtttaat agtactataa
     6901 gatatatttt tttctttgca atagctataa gtgtattaaa cttttttata gcggaacggt
     6961 ttagtatctc tagaagagga atggtatact tcttaacttt agaagggata tccttatact
     7021 tgttaaattt cttagtaaag aaatattgga agcatgtgtt ttttaatcta aaaaatagca
     7081 agaaaatttt actgttaaca gtaacgaaaa atatggaaaa agttcttgat aaattgctag
     7141 aatctgatga actttcatgg aaattggtag cagtaagtgt tttggataaa tctgattttc
     7201 aacatgataa aatacctgta attgaaaagg aaaaaattat tgaatttgca acgcatgaag
     7261 ttgtggatga ggtgtttgtc aatcttccag gagagaacta cgatattgga gaaattatct
     7321 ctaggtttga gacaatgggg atagatgtaa ctgtaaatct taaagcattt gataagaatt
     7381 tgggtcgcaa taaacaaatt catgagatgg taggattgaa tgtagtcact ttctctacaa
     7441 atttttataa aactagtcat gtgatttcaa agagaattct cgatatttgt ggtgccacta
     7501 ttggccttat tctttttgct atagctagtc tagttttagt tccattgatt cgtaaagatg
     7561 gcggaccagc tatttttgct cagacgcgta tagggaaaaa tggtcgatat tttacctttt
     7621 ataaattccg ttcgatgcgg atcgatgctg aagctataaa agaacaattg atggatcaaa
     7681 atacgatgca aggtggtatg tttaagatgg acaatgatcc tcgtgttaca aaaattggtc
     7741 gctttattcg taaaaccagt ttagatgagt taccccagtt ttggaatgtc tttataggag
     7801 atatgagttt ggtgggaaca cgtccaccta cagtagatga gtatgatcag tatactccag
     7861 aacagaaacg tcgactcagc tttaaacctg gtattacagg cttatggcag attagtggcc
     7921 gaagtaaaat aaccgatttt gacgatgttg taaaattaga tgtggcttat attgataatt
     7981 ggacaatttg gaaagatatt gaaattttgc ttaaaactgt taaagttgta tttatgagag
     8041 atggagcgaa gtgaggaatg agggatagaa tccaactttt aggtttaaca attgatctgc
     8101 ttacgatgaa tgaaacgata gatattgtag aacaatatgt attagaaaaa agaccactac
     8161 acttgatggg cgtgaatgct gataaaatta atcagtgcca tacagatgag aaaatcaaaa
     8221 aaatcgttaa tgagtcagga atcattaatg cggatggagc atcagttgtt cttgcaagta
     8281 agtttttagg aacgcctgtt cctgaacgag tagcgggtat tgatttgatg caatgtcttt
     8341 tagagttgtc aaataaaaaa ggatattcag tttacttttt tggagcaaaa gaagaagttt
     8401 tgcaagatat gctcaaagta tttaagagag attatccaaa tttgatagtt attggacaca
     8461 gaaatggcta tttttctgaa gaggatgaac aagctattca agaagatatt cgtgaaaaga
     8521 accctgattt tgtgtttatt ggaattacgt ctcctaaaaa agaatatatt attcaaaaat
     8581 ttatggatag tggcgtcaat tcggtattta tgggagttgg cggtagtttt gatgtcttgt
     8641 ctggtcatat ccaacgagca cctctatgga tgcaaaagtc aaatttagag tggttattcc
     8701 gtgtagctaa tgagcctaaa cgtctcttta aacgttattt tgtagggaat atttcattca
     8761 taggaaaagt tttaaaagca aaaagaggtg taaaatattg aaccagacag agatgattcg
     8821 cttaattcaa aaagttgaat tagatgctat aaaagagttt aaaaaaatct gtgaagagaa
     8881 tgatatagat tttttcctcc gcggtggtag tgtacttggt gcagtcaaat acgacggctt
     8941 tattccatgg gatgatgata tggatatcgc tgtccctcgt gaagcatacg acaaacttcc
     9001 aagtgttttc aaagatagaa ttatcgctgg gaaatatcag gttcttactt atcaatactg
     9061 tgatacgttg cattgctact ttcctcgact atttctttta gaagatgaaa gaaaacgttt
     9121 gggcttgcca cgaaatacca atctgggatt gcatttgatt gatatcattc ctttagatgg
     9181 agcaccaaat cattcggttt taagaaagat ttactttggt aaagtatact ggtatcgttt
     9241 tttagcaagt ttaggaacaa cttatgttgg cgaccatgtg gatatgcatt ccactaagca
     9301 aaaactaatt attggtttct ttaaaaaact aggatttgca aaactatttc ctcaaaattc
     9361 tgtatacaga cgcttggata atctctataa aaagtatgat tggaaaaagc agaagtatgc
     9421 tgggactatc aatgcttctt tatttgccaa agaagttatg ccagtagaga tttggggaga
     9481 aggagtagag aagccttttg aggatacctt ctttaaagtt ccaacggagt atgatcgcta
     9541 cctgaaaaga ctttacggag aaaactatct tcacgaagag ccgagtgatg atgaaaagaa
     9601 atcgcattta gggggataaa aatttgtttt gttatattat tttacattac aaagtcttag
     9661 atgaaactat ttcttgtgtt aaatctataa aagaaggcaa ttccaatgaa aagcaaatcg
     9721 ttattattga taatttttct aataatggta caggtgaaaa actacaagag ctttatgaat
     9781 cagatttaga gattgatgta ttgattaacc acgaaaatgc tggatttgct cgaggaaata
     9841 atgtagctta tcaatttgct aaggaaaagt ataaccccga tttcatggtt atcatgaata
     9901 acgatattga gatagaaaca gaagattttg aaaaaatcgt gacagatatc tatcacaaag
     9961 aaaaatttca tttgctaggg ccagacattt tttcgacaac atatcagcta catcaaaatc
    10021 ctaaacgcct gacacattat acttatgaag aggtagtggc tctcaatgaa aaatttaaaa
    10081 gagggagcca acttagtcta actttaaaaa tcaaatgttg gttgaaagct agcaaagttc
    10141 ttcgaacagc aatctatcaa aatagacgta aaaaaggatc agtagaccat agaaaacagg
    10201 tagaaaaccc gattcttcat ggttccttta ttgtatattc gagagatttt attgaaaaag
    10261 aggagtatgc ttttaaccct aataccttct tttactatga aacagagata ttagattatg
    10321 aagctgagtt aaaaggatac aagagaattt atacaccgaa gattaaggtt ttacaccatc
    10381 aaaatgtggc aacaaatcag gtttatacaa acttagtaga aaaaactttg ttttcaaaca
    10441 aatgcaactt tgaatccact agttattttt taactttaat ggagaaaaat gaataaaaaa
    10501 tgatgaaaaa aattttatat gtgacaaatg ttgattggaa ttggataaaa caacgtccac
    10561 aatttattgc agaaaactta tctaattttt atgagatgct agttctgtat cgctattggt
    10621 acaatagaaa aggattgact gaggatagaa atactaacat tacaaatata tcacgtattt
    10681 atgccctacc ttttgttaat aggtcaccga aactaaagca actgaatgat aaaattgttg
    10741 cttggaatat tcgaagaaaa gttaaggctt ttaaaccgga atatgtatat ttgacaaatc
    10801 caatgcagtt tgcatctctt gtagacaatt cagaacaaaa aataatatat gattgtatgg
    10861 attatcatgt ggcttttata gaaaatagag aagaacgcca gcgattaaag gatttagaag
    10921 agaaactggt caatagagct aatttaatct tggtttcgag tgagaaacta agagaaaata
    10981 ttatttctga ttataacttg gaagagcagg ttaataaaat agtggttgtt agaaatggtt
    11041 ataatggtaa aatcttaagc attcctactc ggcataaaaa gaataaccaa aagcttgtac
    11101 ttgcatatgt tggaactatc agtcattggt ttgactttga tatcatttta cgaagtttaa
    11161 aagattttga taatattgaa tataatttga ttggtccgat tagcaaagct gatattcctg
    11221 aacatgatag aattcattat ttaggaagtg taccacacga gaagatttat cagtatattg
    11281 agaatgcaga tgttctgatt atgccgtttc aaattaatga tattgttgaa gcagtggatc
    11341 cagtcaagtt gtatgaatat attaatttta aaaaaaatat acttacggta tgttataagg
    11401 aaattctgag atttgaacca tttgtataca tgtattcaaa ttatttagat taccaaatga
    11461 atttattgca attgattgaa aataataatt tgaaatatga cagtatagct agagaagatt
    11521 ttttgaaaag taatacttgg gaaaaaagag cggagctgat tcatcagctg attaaccaat
    11581 tgtaattttt tatggagaga tgaatgaaga gacagaagtt tgaatttata gagattctat
    11641 actattttac agtgatgtta tcagtgggaa tgtttcttat gtttaccctc aacttatatt
    11701 ggcacagaaa cttattaact attttatcta ttgctctctc atttttaatg cttcctatac
    11761 tgattgttaa tgctaaaaga atttctaaat ctgcttttat ctatggtact tttttatcta
    11821 tatgtattat atatgagata ttaagagcta aaacactgta taattacagt gtgagtaata
    11881 tttttttggc ctctagacaa tatatatgga tttttctatt ttttgtattg atttaccttt
    11941 ttaaaaacaa acaagaaaat atgagaaaaa ttttagataa tacactcaat atttttatgt
    12001 tttctcttgg aattagagca tttacttggt ttttatatac gttatttcaa gttgaattat
    12061 ttccatctat tttaagagaa ttcggagatt tgtggtatcg aaatgaattt tcagtacgaa
    12121 tagatggaac accattaatt ataataggtt tgttaatttc cacttttttc tattttaaat
    12181 ttggaaatag gaaatacttt tattatttgt tcttgatatt aatgtatata acatttgtaa
    12241 atcagacaag agtgctactg gtttctgttt tgatttcaat ttttcttatg tttgtatttt
    12301 ctagaagaac ttctagattg ctcacctctt taagttttgt aactataatt atagcattcg
    12361 tttatggagg tggattggat tatattaaag catatttaaa tatagatgct ggaacatttg
    12421 atctgggatt aggatttaga tactgggagt tgaaatacta tctgggttta ttagctaatg
    12481 atgtatggaa acttggggtt ggaattctaa catcaagtaa tataaatagt aattttattt
    12541 tggctgggcc aagtgctgtt aagatgtatc tagatgattt aggtttttta gagttattcg
    12601 ttcaatttgg tgtagccgca atttttatgt atggttatat attttataaa ttaatcaatt
    12661 taattctaag aatgtcaaat gataaatata gagttgaccg cgcctttttt attgcactct
    12721 taactaattt aataattact tcaatttctt taaatatctt tggagcgcag agaagtttct
    12781 cattggcaat tgttcttgca ttaatattct actatgacta taggctgaaa aatgacatag
    12841 aaaattaggt gtataatgga taaagtatgt atagttattc tcaattataa taattatgaa
    12901 gaaacgattg agtgtgtaca aagtttgaga agtactataa aatcaaatga gtatgacatc
    12961 gtgattgtag ataataattc ggtgaatgat agtgtcaaag agttatccaa ggcgttatcc
    13021 cctattaaga ttattactag tttagaaaat agaggatatg cgaatggaaa caatattgga
    13081 ataaagtatg ctgaggataa tggatatgat tacatttgta tattaaacaa cgatacatta
    13141 attgaggttg attttttgga atcgtgtaaa cgagaactag aaaataattc cttcgttgcc
    13201 tttgttagtc cagtgttagt tgaatataaa gataataact tggtacaatc tacaggtggt
    13261 gatattttta ttaatagggg aattgtaact ttaaaaaatc atggtgctca gagagacaaa
    13321 cttccttcta aaatcgaaag tgactatatt gggggagcat gtttgatgtt caaaacctct
    13381 atcttgaaaa ttattggata tatacctgaa agttactttc tattttatga agaaactgaa
    13441 tggtgttata gggctaaaaa attaggctat aagaatatat gccttactca aagttatgtt
    13501 tatcataaag gttcggtctc tataaaagcg gtcaatggac ttcaagaata tttaatggca
    13561 agaaatagag ttgtatttgt tcgtagaaat gtaaatagta aactaaagta ttctgctttt
    13621 ttgttctatt tattcatgca acaactttat cattgctttt tgcgaaggga ttgttttaaa
    13681 agaaagtata aatattattt agatggtgta tttaatagaa ttgatccatc ctatccattt
    13741 attttcataa gcgaataagt tactacttat aactgtagat gcactaagat aattatagta
    13801 gactgaatct aaaatagtac gaaataattg ctaaaacatt tatagaaatt aattttattt
    13861 tcccaatcga tttgttctta tcttatttca atctgctata gattaaataa gtaaagaaag
    13921 tggtcattat aggaacataa tttaacatag ttaggtgaaa tatgaaagtg tttgatatat
    13981 ctcaaataaa aacaaaaaca gttgcatttg atttttttga tactattgtg cataggaatt
    14041 gtcatcctga gcaaattttg tatcagtggg ctaaggaaat ggctttggag gtgaatttca
    14101 atatatctcc ttcaatatta taccaaatca gaaaaagtgt cgaaaacaat aaaaagttag
    14161 gcactgaaga aatgtgttat ctagaccttt tgtctggaat atataatgaa attaaagata
    14221 agataaaaaa tacatcgaaa gaagagttta ttcatagagc taaaattcta gagttgaaaa
    14281 ttgaattaca acatatttat ttggattcgg aaattaaaga agttttaaaa aaattgaaaa
    14341 gtgattcaaa acagattatc ttagtttctg atttttatac tgataaagaa ttaatagaaa
    14401 ctgtattaaa aaagtttgaa gtttttgatt atttctcttc tatctatatt tcgagtgaga
    14461 aaggctgccg taaatccaca ggaaatttat ataagttaat tttaaaagaa ttaggcttaa
    14521 atcctaaaga aattaccatg ataggagata attataaatc tgattatgaa gtgccacgtt
    14581 ctctaggatt aaatgctatt tatagacaat acatagataa aaatacaata gtagcagaaa
    14641 aagagttggt aagactatat aatcaaattt tattttctaa cagtaaaaaa gcaccgttta
    14701 atattttttt agctgacatc gtattcttta tttcgaaatt gcataaaaag atgattcaag
    14761 atgatgttca aatagcactc ttttgctcaa gagaaggaca gttattgaaa atactttttg
    14821 atatatatca aaatactttt tttgggaaaa atcaaaagat ttgtacagaa tatttttatg
    14881 tttctagacg atcgacatta tattcttctt ttacttcttt agataatgaa gagtttgaga
    14941 cgatttttcg tcaatataaa aaaattacat tacaaaattt cttgttaaat ttaaactttt
    15001 ctgataatga aatcatattg atttgtcaag atttaaaaga gaaaccaaca tatgtattaa
    15061 cagtagacga tcatttatta gagaaactca aaaaacatcc tcagttcatt acgaagttca
    15121 ataaagagaa aaaagacagt caattactac gtgattatat agagtattta actaaaaacc
    15181 aaaatgaagt atatttagtc gatgtgggtt ggaaaggaac gatacaagat aatatcaaaa
    15241 aggctcttcc agacaagaga atagtaggtt attatctggg attgatactc aatgcttact
    15301 cagtagaaaa taaaatggat aaaactggtt tattgttttc tgattatcca agtaaatcga
    15361 aattttatga tattgtgagt agaaattttg gtttttatga agatattttt gtagcagatc
    15421 atggtccagt tttgaaatat aaaaaagaga gtgatattat ccccattatt gacgatgata
    15481 agaaacatgt gagtatttat caggcagtta aagattatca agaagagtta gtattaggat
    15541 tttcagaaat tttggaagct tataagaaaa tgaagtttct cccttttgaa caaaaaaatc
    15601 tgtggctaat gatgtcgcta aaaaaagaat gtatttatat acctaagtta caatcatttt
    15661 ctgaatcttt aaaagaaaaa gttgttgaaa attttggtga gatagtaact cttaagacta
    15721 cgaaaaaatc tataaaaacg ttattaagaa agaaaagcga tttactttgg gttgatttcg
    15781 tttatagatt gtttggtggt gtcaatttcc tatttattcc agaattatat acaagagtta
    15841 tatttttatt gaaatattta gatttgaaat tgaggttgaa aaattatggg gaataaatcc
    15901 ataaagttga atgcattatt aaatattgtc ctgacgctat caaatatcat tttcccatta
    15961 atcacttttc cttatatatc tagaatattg aatccaaatg gtataggttt aacttcattt
    16021 tttagttcaa tagggaatta tggtatttta cttgcttctc tgggaatttc aacttatggt
    16081 atcaaagcag tagcaagtgt tagagatgat agagataagt tgtcaaaagt agtacaggag
    16141 ttaatgatta taaacgttgc tatgtctata ataacaactg caatactatt atttatgact
    16201 atatttataa cacaattgaa tagagaattt tcactcctat tgatcacatg tgggactatt
    16261 ttatcttctc ctttcgcctt aaattggttg tatagtggaa tggaagaata tacgtatatt
    16321 actactaggt cagtagtgtt taaaattcta tcattaatat tgatttttct acttgtgaaa
    16381 aggccagagg attatattgt ttttgctagt atttcattgt tttcttctct aagttcaaat
    16441 atcttaaatc tatggcatag ccgacatttc attaatatta aattatataa aaatttacaa
    16501 tttaaatatc attttaaacc aatgtggtat ttatttgcct cattacttgc agtaaatatt
    16561 tatactaatt tagatacagt gatgctcggt tttattaatg gtaatgaggc tgtgggatac
    16621 tattctgtgg catcaaaggt taagtggatt ttgctttctc ttattacatc tattagtgca
    16681 gttttgctac cgagactttc attttatatt agtaaaaatg acacctcgaa ttttataaaa
    16741 atgttaaagg agtcatctgc ggttatattt tttattgcga ttccattgat ggtattcttt
    16801 attgtagagg cgaaagatag tatcttatta ctaggaggaa gtcagtatct tcctgcgact
    16861 ttagcgatgc aaatacttat gccaatttta cttatttctg gtttctcgaa tattacagga
    16921 aatcaaatat tgattccaat gaatagagaa aaatatttta tggttgcagt aacgattggt
    16981 gctgtgatta atcttatttt gaatctactg ttaatgccta agtttggaat tattggtgct
    17041 tctgtcgcaa ctctttttgc ggaattgtcg cagatgacgg tacaattaca tttttcaaaa
    17101 gaatatttag tatcaaatat atcgataaag agtttggtta atgtgataat tgcaacagtt
    17161 gtttctacaa taccactaat cattttgaat cagctgataa cgataactat accattttat
    17221 tctctaatgc tagcaggttt tgctttcttt tcattatatt tagtaattct gcttttatta
    17281 aaggaggaag tgacgattca attattttct cttcttgcaa agaagaagta aattggttag
    17341 aaattgaaat gtataaacaa ataaagaatt taattattga tttaggagga aatcatgaag
    17401 ataatgctag tttttggtac acgtccagaa gcgataaaaa tgtgtccatt agtgaatgag
    17461 ttgaaaaaac aggcagatat ggaaacagtt gtttgtgtaa ctggtcaaca caaggagatg
    17521 gttagccctg ttttggaatt gtttggagtt caaccagact atgatttaga aataatgaaa
    17581 gctaatcaaa ccttgttctc tataacaaca agtattttag aaaaaattaa acctgtttta
    17641 gaagaagaac aaccagatat tgttctagtt catggtgaca ctactacaac atatgcagca
    17701 gctttggcag cattttatct tggaattaag gttggccatg ttgaagctgg gttacgaact
    17761 tacaacctgc aaagtccctt cccagaagaa tttaatagac aatcgacttc tattattgca
    17821 aattatcatt ttgctccaac tgaattggct aaagaaaatc tcttaaaaga gggtagagag
    17881 aatgtttatg taactggaaa tacagttatt gatgcactta caactacagt acaaaaggat
    17941 tatacacacc ctgatttaga tttaaacgtt aacactcgtc ttattctact gactgctcat
    18001 agacgtgaaa atctcggaga acctatgaaa cacatgttta gagctgttaa acgagtctta
    18061 aatgaatatg acgatgttaa ggtaatttat ccaattcata agaatccctt ggtgcgtgaa
    18121 acagctacag aaatttttgg agacacagaa cgtattcaga ttattgaacc tttggatgtt
    18181 cttgattttc ataatttcat gaatcatagt tacatgattt taactgattc aggaggagtt
    18241 caggaagagg ctccttcttt aggaaaacct gtattggtca tgcgagatac gacagaaaga
    18301 cctgaaggag tagctgccgg aacgttgaaa ttggttggaa ctgatgagga gactatttat
    18361 caaaacttta agatgctttt agacgattcc gaagaatata aaaaaatgag tcaagctagt
    18421 aatccttatg gaaaaggtga tgctagtaaa cagattgttc atattttaag cggaatttaa
    18481 gcgaggccaa ataaagtaat aaaaaacact atcttataaa aggtattgat cttgtagttg
    18541 attcgggaac atgttcatat cctttgactc gagctacata aaaataactt gtgctgattt
    18601 atgatagatc gataatttac tactactttg gacattgatg ttagcagtta ttagggatgt
    18661 tttgattaac tcaacttttc aggattcgcc ttgctttcta gattttcttc tgatttttat
    18721 cattacttca gtaagttaaa tcgtctattt actagaatta aaacttttaa aaaatccatt
    18781 gttagctcat gttttagata taggtaaaca taaatttagg aggtgttagt ttgaagattg
    18841 taattccaag aattattcat aacaaagaac aactgacctg ggattggtcc gggacaataa
    18901 ctaatataaa aaaattttta gggaaatacg agattgttga ggaacagaat attttctata
    18961 cttttagaat gaatgtgcac aaagtgcttg ttcgtttagg tattaaaaaa tctgatatga
    19021 gcatgacgta tataaaatat gctgaaaatc aagttcatct atcgccagag gatgtttgtc
    19081 tcacgtttga tgaatttcct ttatcttttc ctgataatcc agtttatatc tatcaagact
    19141 taaatcttca ttatttgata gagagttctc aaaacaatag tcaatcgttc aaatatagtg
    19201 gttttcaaaa cgtcccggct gatattctag atagacgaat gagaaaacag gaaatatttt
    19261 ataatcaagc tactggaata tttactatga gtaaatggtt ttcagattac ttgatagctc
    19321 aacaaggact tccagttgaa aaagttcatt atgtgggggc aggaacaaat atgaataatc
    19381 tatttcttga ccactctcat aaggaacgta ataagttttt atttattggt aaagattttt
    19441 ttcgtaaagg aggagatctt gtttataatg cttttgtcta tttgcaaaat aatctcatgc
    19501 cggaggcaga gttgtacatt ataggtcctt cagatgttcc gatggaattt aacaatccga
    19561 atgtttattt tttaggtaat ctatcagctg ataaggtgca atatttttat aatctttgtg
    19621 atgtatttgt tttaccttcc cgatttgagg catttggaat tgtatttgtt gaagctcttt
    19681 gctatggttt accatgtatc ggtcgtgatt taatggaaat gccaaaccta attcaaaata
    19741 atgaaactgg attattatta cctactgaag aggaaaatcc acaggtttta gctgacgtaa
    19801 tgtataattt gataaaagat gaaagctttt ttaaaaatgt tcagactaaa caagattatt
    19861 ataaagcaga atattcgtgg gacacagttg ccaaaagaat gatttcaatt atgaagcaag
    19921 atatgaacaa caatctataa gtgaaaaatt aaaagatatt ctagtctaac ggtctattcc
    19981 tactaacagt aatactgaaa gaaattttaa aatacaagtt atacgtatag tgacttctcc
    20041 taattctgac atggtgaaaa gattatttaa aacctaattt aaaagattaa aggaagttaa
    20101 attcagctta ttgaataaaa ttaatttagt ctagttattt tcttgtcagt cttattcatt
    20161 tttttccgaa ccttgtgagt tgtttgcaac taccagaata cacaaagaac agaatctctt
    20221 agcatcattg aatagaacaa tatctgcata aatttcagat ataactagtg gtgcagaaag
    20281 tggatctttg aaaataagaa ttctttgtag agctatttca ctagctggtg aagaattgtt
    20341 tttcaatttt tcgtacagat tacaataatg ttatggtggg tttaaatttc tttgttggtt
    20401 gtgtttgatg aatagagatg cacgtatcga aattcaagat agtggtgata tcgcttgctt
    20461 aatctcttct ccagtatttg tagtagaatt aagtgttctt gattaaaata aagaacacaa
    20521 cactttttat tcagtgttgt gtattgggtg aaacgaaagg aacgattgta cttatgaaag
    20581 gtattattct cgcgggtggt tcggggacac gtttatatcc tttgactcga gctgcatcaa
    20641 agcaactgat gccggtttat gataaaccga tgatttacta cccactttca actttgatgt
    20701 tggctgggat tagggatatt ttgattatct caactcctca agatttgcct cgttttaaag
    20761 agctccttca agatggctct gagtttggga ttcaattgtc ttatgcagag caaccgagtc
    20821 cagatggttt ggcacaagcc tttattattg gtgaagaatt tattggtgat gatagcgttg
    20881 cgctaatctt aggtgataat atctaccatg gttctgggct ttccaagatg ctacaaaagg
    20941 cagcgagtaa ggagtcggga gcaactgttt ttggctacca tgtcaaggat ccagagcgct
    21001 ttggtgtggt tgagtttgat caggatatga aggctatttc tattgaagaa aagccagagc
    21061 aacctcgttc aaactatgca gttacaggtc tctatttcta tgataatgat gtagtagaga
    21121 ttgccaagag tattaaacca agtcctcgtg gtgaactgga aattacagat gtaaacaagg
    21181 cttacctaga tcgtggtgat ttgtctgttg agcttatggg acgtggcttt gcttggctgg
    21241 atactggaac tcatgaaagt ttactagagg cttcacagta catcgaaaca gtgcaacgga
    21301 tgcaaaatgt tcaggtagca aacttagaag aaattgctta ccgtatgggc tatatcagtc
    21361 gagaagatgt attggcctta gcccaaccac ttaagaaaaa tgaatacgga cagtatctgc
    21421 tccgtttgat tggagaagca tagatgacag ataagttttt cggtaagacg cttgcggcac
    21481 gcaaggttga agctattcca ggcatgttgg agtttgatat ccccgttcat ggagataatc
    21541 gtggctggtt taaagaaaat ttccaaaagg aaaaaatgct tccacttgga tttccagagt
    21601 ctttctttgc agaaggaaaa ttgcaaaaca atgtatcctt ctcacgtaaa aatgtccttc
    21661 gagggctcca cgcagagcct tgggataagt acatctctgt agcagatgga gggaaagttc
    21721 tgggttcttg ggttgatcta cgcgagggtg aaacctttgg gaatacctat cagacagtaa
    21781 ttgatgcaag caagggaatc tttgttcctc gaggcgtagc taatggcttc caagttctat
    21841 cagatacagt gtcatatagc tatctggtca atgattactg ggctctcgag ctcaaaccca
    21901 agtatgcctt tgtgaactac gctgatccaa gccttggtat tgaatgggaa aatattgcag
    21961 aagcagaggt ttcagaagca gataaacatc atcccctact taaggatgta aaacctttga
    22021 aaaaagaaga tttgtaaaaa ggaaagaata tgactgaata caaaaatatt atcgtgacag
    22081 gtggagctgg ctttatcggt tctaactttg tccattatgt ttacgagaac tttccaggtg
    22141 ttcacgtgac agtcctagat aagttgactt atgctggaaa tcgcgcgaat attgaggaaa
    22201 ttttaggtaa tcgtgttgag ttagttgttg gtgacattgc tgatgcggag ttggtagaca
    22261 agttggctac tcaagcagat gctatcgttc attatgcagc ggaaagccac aatgataatt
    22321 cgctcaatga tccatcgcca tttattcata ctaacttcat cggaacctat actcttttag
    22381 aagctgctcg taagtatgat attcgcttcc accatgtatc gacagatgaa gtttatgggg
    22441 atctcccttt acgcgaagat ttgccaggtc atggagaagg gccgggtgag aaatttacgg
    22501 ctgaaaccaa gtacaatcca agctcgcctt actcatcaac caaggcagcc tcagatttga
    22561 ttgtcaaagc ctgggtgcgt tcttttggag tcaaggcaac gatttccaac tgttcaaata
    22621 actacggtcc ttaccagcat attgagaagt ttattccacg acaaatcacc aatatcttga
    22681 gcggtatcaa gccaaaactt tacggtgaag gtaagaacgt tcgtgactgg attcatacca
    22741 atgaccattc ttcaggagtt tggacaatct tgacaaaagg gcaaatcggt gaaacctact
    22801 tgattggggc tgatggtgag aagaacaata aggaagtttt ggaacttatc cttaaggaaa
    22861 tgggacaagc tgcggatgcc tatgatcatg tgactgaccg tgcaggacat gaccttcgct
    22921 atgcgattga tgctagcaag ctccgtgatg agttggggtg gaaacctgaa tttaccaact
    22981 ttgaagctgg gctcaaggca acaatcaagt ggtatacaga taaccaagaa tggtggaaag
    23041 cagaaaaaga agctgttgaa gccaattatg ctaagactca ggagattatt acagtataaa
    23101 aagcaggaaa tagctgcttt ttattgctat attgggaaga gttacatatt agaaaggtct
    23161 agagatgatt ttaattacag gggcaaatgg ccaattagga acggaacttc gctatttatt
    23221 ggatgaacgt aatgaagaat acgtggcagt agatgtggct aagatggaca ttaccaatga
    23281 agaaatggtt gagaaagttt ttgaagaggt gaaaccgact ttagtctacc attgtgcagc
    23341 ctacaccgct gttgatgcag cagaggatga aggaaaagag ttggacttcg ccatcaatgt
    23401 gacggggaca aaaaatgtcg caaaagcatc tgaaaagcat ggtgcaactc tagtttatat
    23461 ttctacggac tatgtctttg atggtaagaa accagttgga caagagtggg aagttgatga
    23521 ccgaccagat ccacagacag aatatggacg cactaagcgt atgggggaag agttagttga
    23581 gaagcatgtg tctaatttct atattatccg tactgcctgg gtatttggaa attatggcaa
    23641 aaacttcgtt tttaccatgc aaaatcttgc gaaaactcat aagactttaa cagttgtaaa
    23701 tgaccagtac ggtcgtccga cttggactcg taccttggct gagttcatga cctacctagc
    23761 tgaaaatcgt aaggaatttg gttattatca tttgtcaaat gatgcgacag aagatacaac
    23821 atggtatgat tttgcagttg aaattttgaa agatacagat gtcgaagtca agccagtaga
    23881 ttccagtcaa tttccagcca aagctaaacg tccgctaaac tcaacgatga gcctggccaa
    23941 agccaaagct actggatttg ttattccaac ttggcaagat gcattgcaag aattttacaa
    24001 acaagaagtg agataagtag tagaatgatt ttctagtcta ataaaagagg cagagaatga
    24061 actccaaagg agcttaagat gtacgattat cttgttgttg gtgcagtctt tgcccatgaa
    24121 gcagtcttaa aaggaaaaaa agtaaaagtt attgaaaaat gaaatcatat cgcgggtaat
    24181 atctatactc gtgaagagga aggaattcaa gttcatcaat atggtgctca tatcttccat
    24241 acttctgata aggagatctg ggattatgta aatcagtttg cagagtttaa ccgttacata
    24301 aattctcctg ttgcaaacta taagggtgag atttataacc ttccttttaa tatgaatact
    24361 ttcaataaac tctggggagt tgtaacgcca gcagaagcac aagctaagat tgatgaacaa
    24421 cgtgctattt taaatggtaa aactcctgaa aatttggaag aacaggcgat ttctcttgta
    24481 gctacagaca tctacgaaaa attaatcaaa gactatacag agaaacagtg gggcaaacca
    24541 actactgaac ttccatcctt tattattgtt tgccagtacg cctgacctat gataacaact
    24601 attttaacga tacctatcaa gggattccaa ttggtagata cactcaaata gttgaaaaat
    24661 gttggatcat gaaaatattg atgtagaaac aaacgttgat ttctttgtga ataaagagca
    24721 atatctgaaa gattttccta agattgtctt tactggtatg attgatgaat tctttgacta
    24781 taagttgggc gaactagagt accgtagtct tcgttttgaa aatgagacct tggatatgga
    24841 aaattaccaa ggaaatgcag ttgtgaacta tacggatgca gaaaccccat atactcgcat
    24901 tattgaacac aaacattttg agtttgggag tcaagcaaag actatcatta ctaaagaaca
    24961 ttctaaaaca tgggaaaaag gtgatgagcc ttattatcca gttaataatg atcgtaataa
    25021 tcatttgtat aaatcatata aaaaacttgc tgatgagcaa gggaatgtta tctttggtgg
    25081 ccgcttagga cactatcgtt attacgatat tcaccaagta attggagcag ctttgcagtg
    25141 cgtgagaaat gagttaaatt aatactcaat gaaaatcaaa gagcaaacta ggaagctagc
    25201 cacaggttgc tcaaaacact gttttgaggt tgcagatgga cgctgacgcg gtttgaagag
    25261 attttcgaag agtataaaca agtaaaactg actaccagtt attatttaga aatagtatta
    25321 aaaattcctt gactatgtga tatagttgag ggatttttaa atgatattca tattttttgc
    25381 aaagatgttg tttgaaaaat aattttcaaa aattctgaaa attctgttga caactttctg
    25441 aaaagagtct ataatggaga gaaagtttta aaggagaaaa tgatgaaaag ttcaagacta
    25501 tttgcccttg cgggcgtgac attattggcg gcgactactt tagctgcatg ctctggatca
    25561 ggttcaagca ctaaaggtga gaagacattc tcatacattt atgagacaga ccctgataac
    25621 ctcaactatt tg
//
