LOCUS       CR931678               19798 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 485/61 (serotype 19f).
ACCESSION   CR931678
VERSION     CR931678.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19798)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 19798)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..19798
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="485/61"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC19F_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC19F_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI33688.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            293..461
                     /gene="aliB"
                     /locus_tag="SPC19F_0002"
                     /pseudo
     CDS             293..461
                     /gene="aliB"
                     /locus_tag="SPC19F_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            1107..2384
                     /gene="intron"
                     /locus_tag="SPC19F_0003"
     CDS             1107..2384
                     /gene="intron"
                     /locus_tag="SPC19F_0003"
                     /note="member of homology group 108"
                     /codon_start=1
                     /transl_table=11
                     /product="putative group II intron protein"
                     /protein_id="CAI33690.1"
                     /db_xref="GOA:Q4K0V6"
                     /db_xref="InterPro:IPR000477"
                     /db_xref="InterPro:IPR013597"
                     /db_xref="InterPro:IPR015706"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V6"
                     /translation="MSKLLDKILSRENMLEAYNQVKSNKGSAGIDGMTIEEMDNYLRQ
                     NWRLTKELIKQRKYKPQPVLKVEIPKPDGGIRQLGIPTVMDRMIQQAIVQVMSPICEP
                     HFSDTSYGFRPNRSCEKAIMKLLEYLNDGYEWIVDIDLEKFFDTVPQDRLMSLVHNII
                     EDGDTESLIRKYLHSGVIINGQRYKTLVGTPQGGNLSPLLSNIMLNELDKELEKRGLR
                     FVRYADDCVITVGSEAAAKRVMYSVSRFIEKRLGLKVNMTKTKITRPRELKYLGFGFW
                     KSSDGWKSRPHQDSVRRFKLKLKKLTQRKWSIDLTRRIEQLNLSIRGWINYFSLGNMK
                     SIVASIDERLRTRLRVIIWKQWKKKSRRLWGLLKLGVPKWIADKVSGWGDHYQLVAQK
                     SVLKRAISKPVLEKRGLVSCLDYYLERHALKVS"
     misc_feature    1281..1931
                     /gene="intron"
                     /locus_tag="SPC19F_0003"
                     /note="HMMPfam hit to PF00078, Reverse transcriptase
                     (RNA-dependent DNA pol, score 1.3e-65"
     misc_feature    1977..2228
                     /gene="intron"
                     /locus_tag="SPC19F_0003"
                     /note="HMMPfam hit to PF08388, Group II intron,
                     maturase-specific domain, score 5.5e-30"
     gene            complement(2441..3226)
                     /gene="tnp"
                     /locus_tag="SPC19F_0004"
                     /pseudo
     CDS             complement(2441..3226)
                     /gene="tnp"
                     /locus_tag="SPC19F_0004"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(2855..3226)
                     /gene="tnp"
                     /locus_tag="SPC19F_0004"
                     /note="HMMPfam hit to PF01710, Transposase, score 1.1e-14"
                     /pseudo
     gene            3475..4920
                     /gene="wzg"
                     /locus_tag="SPC19F_0005"
     CDS             3475..4920
                     /gene="wzg"
                     /locus_tag="SPC19F_0005"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33692.1"
                     /db_xref="GOA:Q4K0V5"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V5"
                     /translation="MSRRFKKSRSQRVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAIIQKLTST
                     EVLKNYSSILQGLQDSLQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    3475..3591
                     /gene="wzg"
                     /locus_tag="SPC19F_0005"
                     /note="Signal peptide predicted for SPC1032 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    3679..4026
                     /gene="wzg"
                     /locus_tag="SPC19F_0005"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.6e-64"
     misc_feature    4204..4647
                     /gene="wzg"
                     /locus_tag="SPC19F_0005"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 3.5e-70"
     gene            4922..5653
                     /gene="wzh"
                     /locus_tag="SPC19F_0006"
     CDS             4922..5653
                     /gene="wzh"
                     /locus_tag="SPC19F_0006"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33693.1"
                     /db_xref="GOA:Q4K0V4"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V4"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKVKELFVDNPRKIIMDQLI"
     misc_feature    4925..5533
                     /gene="wzh"
                     /locus_tag="SPC19F_0006"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.3e-37"
     gene            5662..6354
                     /gene="wzd"
                     /locus_tag="SPC19F_0007"
     CDS             5662..6354
                     /gene="wzd"
                     /locus_tag="SPC19F_0007"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33694.1"
                     /db_xref="GOA:Q4K0V3"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V3"
                     /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSMTRIYVVNRNQGEKSGLTNQDLQAGSSLVKDYREIILSQDVLEEVVSDLKLD
                     LTPKDLANKIKVTVPVDTRIVSVSVSDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPATSPSSPNIKRSTLIVFLAGVIGTSVIVLILELLDTRVKRPKDIEDTLHMT
                     LLGIVPNLNKLK"
     misc_feature    5680..6096
                     /gene="wzd"
                     /locus_tag="SPC19F_0007"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 3.4e-52"
     gene            6364..7053
                     /gene="wze"
                     /locus_tag="SPC19F_0008"
     CDS             6364..7053
                     /gene="wze"
                     /locus_tag="SPC19F_0008"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33695.1"
                     /db_xref="GOA:Q4K0V2"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V2"
                     /translation="MPTLEIAQKKLEFVKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PEEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGTVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVVLNKLDISVDKYGVY
                     GFYGNYGKKII"
     gene            7064..8431
                     /gene="wchA"
                     /locus_tag="SPC19F_0009"
     CDS             7064..8431
                     /gene="wchA"
                     /locus_tag="SPC19F_0009"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33696.1"
                     /db_xref="GOA:Q4K0V1"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0V1"
                     /translation="MDEKGLKIFLAVLQSIIVILLVYFLSFVRETELERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMG
                     IDVTVNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVIAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYVQYTSE
                     QKRRLSFKPGITGLWQVSGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    7847..8428
                     /gene="wchA"
                     /locus_tag="SPC19F_0009"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 4.7e-155"
     gene            8435..9178
                     /gene="wchO"
                     /locus_tag="SPC19F_0010"
     CDS             8435..9178
                     /gene="wchO"
                     /locus_tag="SPC19F_0010"
                     /note="member of homology group 33"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33697.1"
                     /db_xref="GOA:Q54522"
                     /db_xref="InterPro:IPR004629"
                     /db_xref="UniProtKB/TrEMBL:Q54522"
                     /translation="MRDRIQLLGVTIDLLTMNETIDSVEQYVLEKRPLHLMGVNADKI
                     NQCHTDEKIKKIVNESGIINADGASVVLASKFLGTPVPERVAGIDLMQCLLELSNKKG
                     YSVYFFGAKEEVLQDMLKVFKRDYPNLIVIGHRNGYFSEEDEQAIQEDIREKNPDFVF
                     IGITSPKKEYIIQKFMDSGVNSVFMGVGGSFDVLSGHIQRAPLWMQKSNLEWLFRVAN
                     EPKRLFKRYFVGNISFIGKVLKAKRGVKY"
     misc_feature    8597..9112
                     /gene="wchO"
                     /locus_tag="SPC19F_0010"
                     /note="HMMPfam hit to PF03808, Glycosyl transferase
                     WecB/TagA/CpsF f, score 1.6e-95"
     gene            9175..9999
                     /gene="wchP"
                     /locus_tag="SPC19F_0011"
     CDS             9175..9999
                     /gene="wchP"
                     /locus_tag="SPC19F_0011"
                     /note="member of homology group 95"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI33698.1"
                     /db_xref="GOA:Q4K0U9"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4K0U9"
                     /translation="MNQTEMIRLIQKVELDAIKEFKKICEENDIDFFLRGGSVLGAVK
                     YDGFIPWDDDMDIAVPREAYDKLPSVFKDRIIAGKYQVLTYQYCDTLHCYFPRLFLLE
                     DERKRLGLPRNTNLGLHLIDIIPLDGAPNHSVLRKIYFGKVYWYRFLASLGTTYVGDH
                     VDMHSTKQKLIIGFFKKLGFAKLFPQNSVYRRLDNLYRKYDWKKQKYAGTINASLFAK
                     EVMPVEIWGEGVEKPFEDTFFKVPTEYDRYLKRLYGENYLYEEPSDDEKKSHLGGH"
     misc_feature    9247..9936
                     /gene="wchP"
                     /locus_tag="SPC19F_0011"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     5.5e-109"
     gene            10001..10879
                     /gene="wchQ"
                     /locus_tag="SPC19F_0012"
     CDS             10001..10879
                     /gene="wchQ"
                     /locus_tag="SPC19F_0012"
                     /note="member of homology group 43"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33699.1"
                     /db_xref="GOA:P97000"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:P97000"
                     /translation="MFCYIILHYKVLEETISCVKSIKEGNYNAKQIVIIDNFSNNGTG
                     EKLQELYESDLEIDVLINHENAGFARGNNVAYQFAKEKYNPDFMVIMNNDIEIETENF
                     EKIVTDIYREEKFHLLGPDIFSTTYQLHQNPKRLTHYTYGEVKALNEKFKKGSQVSLA
                     LKIKCWLKASKVLRTAIYQNRRKKGSVDYRKQVENPILHGSFIVYSRDFIEKEEYAFN
                     PNTFFYYETEILDYEAELKGYKRIYTPKIRVLHHQNVATNQVYTNLLEKTLFSNKCNF
                     KSTSYFLKLMKENEDV"
     misc_feature    10007..10546
                     /gene="wchQ"
                     /locus_tag="SPC19F_0012"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 5.1e-11"
     gene            10880..12217
                     /gene="wzy"
                     /locus_tag="SPC19F_0013"
     CDS             10880..12217
                     /gene="wzy"
                     /locus_tag="SPC19F_0013"
                     /note="member of homology group 161"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33700.1"
                     /db_xref="UniProtKB/TrEMBL:P97001"
                     /translation="MSYLFLLCLTLFLLTIFYFFAFIQDLIAPPVVMSVMFLISSVFA
                     LVNSKNWNIEYSGIAYILIISGIIIFSIPLMALKSPNFNTEVKIADRLIDIQFWKIAL
                     TIIIDLFILYLYRKEIYNLVLSNGYTGSNIQWFFRNATSYEGELTVRTFIRVLIRVID
                     VSAYIFGYTFINNFLIYRHKRPKDILLLVPLLIFISKTLISGGRQDIIKILIAYVIMM
                     YIQQKRKVGWNRVISHKYIHLGFVGLIAGIPAFYYSLFLAGRSTTRTLFESVSTYLGG
                     SIQHFNQYIENPLDPGEVFGSETLVPILNILGEMGLVNYRSTIHLEFRTLGVTVGNVY
                     TFFRRPLHDFGLVGMYVFVFAVGAFFAIYYLVLRKKQVGFNLDIHTIIYSYVFYWIFL
                     SSIEQYSFTMISLYTLVFIVLVYFMAIFYWCTDFKRGKLIFKISDSSIKLKEE"
     misc_feature    10880..11011
                     /gene="wzy"
                     /locus_tag="SPC19F_0013"
                     /note="Signal peptide predicted for SPC1040 by SignalP 2.0
                     HMM (Signal peptide probability 0.993) with cleavage site
                     probability 0.610 between residues 44 and 45"
     gene            12240..13661
                     /gene="wzx"
                     /locus_tag="SPC19F_0014"
     CDS             12240..13661
                     /gene="wzx"
                     /locus_tag="SPC19F_0014"
                     /note="member of homology group 82"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33701.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0U6"
                     /translation="MNTKIKNIITSFSYVISSNLLIVLTSSLVVLIFPKIMGVTEYSY
                     WQLYIFYLTYIGFFHLGWIDGIYLKYGGLEYTNLDRKQFYSQMILFSSFLMLISLVLF
                     TLNLITVRDENARYIYNMAIISMIVTNLRTLYVYILQMTNRLKDSSVILISDRVLYVL
                     LLFMFIVFGWHEYKVMIWADILGRTFSLMLSFWICKDIVFQPLSKFILDFKESLDNIR
                     VGINLMLSNIASSMIIGIVRMGIQWNWNIETFGKVSLTLSISNLLMTFINAIGLVIFP
                     LIKRTKTENLPKIYSNLRNALMLVMFAILLFYYPLKFILDIWLPAYKDALVFMALIFP
                     MSVYEGKMALVINTYLKAMRMEKDILKINALVMLTSIVVTLVTTILLNNLGLTVVSIV
                     ILLALRSIIAELILSKKLKISVKQDIALELLMTIIFISSSWYLSIWIAVIIYLLAYTL
                     YLYLKHKDIRMYIEYFKNHKKIS"
     misc_feature    12240..12359
                     /gene="wzx"
                     /locus_tag="SPC19F_0014"
                     /note="Signal peptide predicted for SPC1041 by SignalP 2.0
                     HMM (Signal peptide probability 0.685) with cleavage site
                     probability 0.363 between residues 40 and 41"
     gene            13725..14813
                     /gene="mnaA"
                     /locus_tag="SPC19F_0015"
     CDS             13725..14813
                     /gene="mnaA"
                     /locus_tag="SPC19F_0015"
                     /EC_number="5.1.3.14"
                     /note="member of homology group 23"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine-2-epimerase MnaA"
                     /protein_id="CAI33702.1"
                     /db_xref="GOA:Q4K0U5"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4K0U5"
                     /translation="MKKIMLVFGTRPEAIKMCSLVNELRKQEDMKTVVCVTGQHKEMV
                     SPVLDLFGVQPDYDLEIMKANQNLFSITISILEKIKPVLEKEQPDIVLVHGDTTTTYA
                     AALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIANYHFAPTELAKENLIKE
                     GRNNIYVTGNTVIDALTTTVQKDYTHPDLDLNDGNRLILLTAHRRENLGEPMRHMFRA
                     VKRVLNEYDDVKVIYPIHKNPLVRETATEIFGDTERIQIIEPLDVLDFHNFMNHSYMI
                     LTDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKMLLDDPE
                     EYKKMSQASNPYGNGDASKQIVRILRGI"
     misc_feature    13788..14804
                     /gene="mnaA"
                     /locus_tag="SPC19F_0015"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 1.3e-195"
     gene            14852..15721
                     /gene="rmlA"
                     /locus_tag="SPC19F_0016"
     CDS             14852..15721
                     /gene="rmlA"
                     /locus_tag="SPC19F_0016"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33703.1"
                     /db_xref="GOA:P97004"
                     /db_xref="HSSP:1FXO"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:P97004"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLHRFQELLQDGSEFGLKLSYAEQPSPDGLAQAFIIGEEFISDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    14855..15571
                     /gene="rmlA"
                     /locus_tag="SPC19F_0016"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 1.1e-119"
     gene            15722..16318
                     /gene="rmlC"
                     /locus_tag="SPC19F_0017"
     CDS             15722..16318
                     /gene="rmlC"
                     /locus_tag="SPC19F_0017"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33704.1"
                     /db_xref="GOA:P97005"
                     /db_xref="HSSP:1NZC"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:P97005"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    15758..16288
                     /gene="rmlC"
                     /locus_tag="SPC19F_0017"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            16328..17377
                     /gene="rmlB"
                     /locus_tag="SPC19F_0018"
     CDS             16328..17377
                     /gene="rmlB"
                     /locus_tag="SPC19F_0018"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33705.1"
                     /db_xref="GOA:O54546"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54546"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    16343..17299
                     /gene="rmlB"
                     /locus_tag="SPC19F_0018"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00012"
     misc_feature    16346..17086
                     /gene="rmlB"
                     /locus_tag="SPC19F_0018"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    16349..17161
                     /gene="rmlB"
                     /locus_tag="SPC19F_0018"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.4e-05"
     gene            17443..18294
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
     CDS             17443..18294
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33706.1"
                     /db_xref="GOA:P97007"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:P97007"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVARASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    17443..18291
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.9e-148"
     misc_feature    17446..18075
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 3.5e-19"
     misc_feature    17446..18087
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 9.7e-05"
     misc_feature    17449..18177
                     /gene="rmlD"
                     /locus_tag="SPC19F_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.9e-08"
     gene            order(18370..19323,19340..19555)
                     /gene="tnp"
                     /locus_tag="SPC19F_0020"
                     /pseudo
     CDS             join(18370..19323,19340..19555)
                     /gene="tnp"
                     /locus_tag="SPC19F_0020"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    18376..18819
                     /gene="tnp"
                     /locus_tag="SPC19F_0020"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 8e-05"
                     /pseudo
     gene            19751..>19798
                     /gene="aliA"
                     /locus_tag="SPC19F_0021"
     CDS             19751..>19798
                     /gene="aliA"
                     /locus_tag="SPC19F_0021"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33708.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ89"
                     /translation="MMKSSKLLALAGVTLL"
BASE COUNT     6359 a   3114 c   4118 g   6207 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaataag
      181 ggaggactgt ataaaagaca gaaatccttt gttttttata accaaggttt ataaactttc
      241 attctcgaaa ttcaattaac tttacaaatt ctcactatta aggagaaaga agatgaacat
      301 aaagaagcgt gtccttagtg caggtctgac ttttgcatct gctttgcttt tagctgcttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac
      421 atttaattac ctgttagact attacgctga taatatagtc aattgaaaca agaacaagac
      481 aaaagagcct tgtaaaaggt attgcaactt ggtaatacct ttttgatgta cgacgggcat
      541 gtcgtatatc tgaggtgtaa gtcctcggtg ggcacctgct accagtgaac ccaatagcga
      601 ttcccaagcc tgactatcgt gaggtagcag ggagaggaag ggatagcgaa atcgtggctc
      661 tacgaacagg aacgtgatag taaggcgtat atagcggata agggggcctc aaactctaaa
      721 gtccaaaaag gtagtcgtaa cctgtatgcg taaatcacga gagtaattga attcggacta
      781 agatttccta ttttcactgt aaccttttaa cgtcctcata tcttgtataa acgaggaaag
      841 atgtacgatt tatcccgtga ggtctcatga gcgctgaaag cgtagtaaca acgaatcatg
      901 agaagtcagc cgaacccata gtagtgagga aacttctgta gtggaagtgg agcgaagggg
      961 tgagcaacta attgaagtaa tcctacttca cttgtgtctg taaaacgaga ggtctgatag
     1021 aactggagtc tgtcacgtat tgactagatg aaggttcacc aatataagat gtccctcagg
     1081 caccaaaaca agaaaggaat acgcacatgt caaaactgct agataagata ttatcacgcg
     1141 aaaatatgct ggaagcctac aatcaagtaa aatccaataa aggctcagct gggattgatg
     1201 gaatgactat cgaagagatg gataattatc tcagacaaaa ctggcgcttg actaaggaac
     1261 tgataaaaca gagaaaatat aagcctcaac cagttcttaa agttgagata cctaaaccag
     1321 acggaggcat ccgtcaacta ggaattccaa cagttatgga tagaatgatt caacaggcca
     1381 ttgtccaagt catgagcccc atttgtgaac cccatttctc agatacgagt tatggtttca
     1441 gaccaaatag gtcatgtgaa aaagccatca tgaagctctt agaatactta aatgacggct
     1501 atgagtggat agtggatata gacctagaga aatttttcga tacagttcct caagatagat
     1561 tgatgtcctt agtacataac attatcgaag acggagatac ggaatccttg attcgtaagt
     1621 atcttcattc aggtgttatc attaatggtc aacgttataa aacactagtt ggtacaccac
     1681 agggaggaaa tttatctcct ctcttatcca atatcatgct taatgaattg gacaaggaat
     1741 tagaaaagag gggacttcga tttgtgcgct acgcagatga ttgtgtgatt acggtcggaa
     1801 gcgaggcagc cgctaagcgt gtgatgtatt cagtcagtcg ttttattgag aaacggctag
     1861 gtttgaaagt aaacatgacc aagactaaga ttaccagacc aagagagttg aaatatctag
     1921 gttttgggtt ctggaaatca tcagatggtt ggaaaagccg tccacatcaa gatagtgttc
     1981 ggagatttaa gcttaaattg aagaaactaa cacagaggaa atggagtata gacctaacaa
     2041 gacgtattga gcaactgaat ttgtctattc gaggatggat aaactatttc tcattgggaa
     2101 atatgaaaag tatagtcgcc agcatagatg agcgcttgcg tactcgccta cgagtgatta
     2161 tctggaagca atggaagaag aaatcgagac gattatgggg attgcttaag ttaggagttc
     2221 ctaaatggat agcagataag gtatctggct ggggcgacca ttatcaatta gtagctcaga
     2281 agtcggtact taaacgtgct atatcaaaac cagtcctgga aaaacgtgga ctggtttcgt
     2341 gtttggatta ttaccttgaa cgacatgcgt taaaagttag ttgaaccgcc gtatgccgaa
     2401 cggcacgtac ggtggtgtga gaggggctag agattatccc ctactcgatg tgctttttga
     2461 tatgagccca tgttttctca ataggattgt actcaggtga gtagggagga agaggtaaaa
     2521 gtttacgccc aaactcttca cataagagtt ctagcttccc cattctatgg aatcttgcat
     2581 tatccataat aataaccgat ggtgtggtta atgttggtaa gagaaacttc tgaaaccaag
     2641 cttcaaaaaa gtcgctcgtc atcgtctctt cgtaagtcat tggagcgatt aactcaccat
     2701 ttgttagacc tgaaaccaaa gaaatcctct gatatcttct tccagatact ttgcctcttc
     2761 ttaactgacc ttttaatgag cgaccatatt ctcgataaaa ataagtatcg aatcctgttt
     2821 cgtcaatcta aacaggtgct aggtgcttta aactattaaa attcttaaga aataaggcta
     2881 cttttctggg tcttgttcat agtaggtgtg gttctttttt tagagtgtag cccatagctt
     2941 tgagcgcata gtggatggta gttggatgac agccaaattc agaagctatt tcagtcaaat
     3001 aagcgtctgg attgtcagta agatagtttt taagtctatc tctatcaact tttcttggtt
     3061 ttattccttt tacttggtgg tttagctctc ctgttttctc ttttagcttt aaccagccat
     3121 aaatggtatt acgtgagatt tggaaaacgt gtgatacttc tgttatacta cctgttcgct
     3181 cacaataaga gagaactttt ttacgaaaat ctattgaata ttccataaaa gattatacca
     3241 cattgtgtac tatagtagat tgaaactaga atagtacacc tctgcttcta aaacattgtt
     3301 agaaatcgat ttgactgtcc tgatcgattt gtcatgttct tatttcattt tactatattt
     3361 ttgtttcgcg ggaagtctac taagatactt aaagatgcag atagtaaaaa aaatgtagac
     3421 attaccgtaa aaaagtgata taatcgtatg atgttcaagg tataggtgtt aatcatgagt
     3481 agacgtttta aaaaatcacg ttcacagaga gtgaagcgaa gtgttaatat cgttttgctg
     3541 actatttatt tattgttagt ttgtttttta ttgttcttaa tctttaagta caatatcctt
     3601 gcttttagat atcttaacct agtggtaact gcgttagtcc tactagttgc cttggtaggg
     3661 ctactcttga ttatctataa aaaagctgaa aagtttacta tttttctgtt ggtgttctct
     3721 atccttgtca gctctgtgtc gctctttgca gtacagcagt ttgttggact gaccaatcgt
     3781 ttaaatgcga cttctaatta ctcagaatat tcaatcagtg tcgctgtttt agcagatagt
     3841 gatatcgaaa atgttacgca actgacgagt gtgacagcac cgactgggac tgataatgaa
     3901 aatattcaaa aactactagc tgatattaag tcaagtcaga ataccgattt gacggtcaac
     3961 cagagttcgt cttacttggc agcttacaag agtttgattg caggggagac taaggccatt
     4021 gtcctaaata gtgtctttga aaacatcatc gagtcagagt atccagacta cgcatcgaag
     4081 ataaaaaaga tttataccaa gggattcact aaaaaagtag aagctcctaa gacgtctaag
     4141 aatcagtctt tcaatatcta tgttagtgga attgacacct atggtcctat tagttcggtg
     4201 tcgcgatcag atgtcaatat cctgatgact gtcaatcgag ataccaagaa aatcctcttg
     4261 accacaacgc cacgtgatgc ctatgtacca atcgcagatg gtggaaataa tcaaaaagat
     4321 aaattaaccc atgcaggcat ttatggagtt gattcgtcca ttcacacctt agaaaatctc
     4381 tatggagtgg atatcaatta ctatgtgcga ttgaacttca cttctttctt gaaaatgatt
     4441 gacttattgg gaggggtaga tgttcataat gatcaagagt tttcagctct acatgggaag
     4501 ttccatttcc cagtagggaa tgtccatcta gactctgagc aggctctagg ttttgtacgt
     4561 gaacgctact cactagccga tggagaccgt gaccgtggtc gcaaccaaca aaaggtcatt
     4621 gtagcaatta ttcagaagtt aacttctaca gaggttttga aaaactatag tagtattctt
     4681 caaggattgc aggattctct tcaaacaaat atgccgattg agactatgat agatttagtg
     4741 aatactcagt tggaaagtgg ggggaattat aaagtaaatt ctcaagattt aaaagggaca
     4801 ggtcggatgg atcttccttc ttatgcaatg ccagacagta acctctatgt gatggaaata
     4861 gatgatagta gtttagctgt agttaaagca gctatacagg atgtgatgga gggtagatga
     4921 aatgatagac atccattcgc atatcgtttt tgatgtagat gacggtccca agtcaagaga
     4981 ggaaagcaag gctctcttgg cagaatccta caggcagggg gtgcgaacca ttgtctctac
     5041 ctctcaccgt cgcaagggca tgtttgaaac tccggaagag aagatagcag aaaactttct
     5101 tcaggttcgg gaaattgcaa aagaagtggc agatgattta gtcattgctt atggcgcaga
     5161 gatatactat actctggatg ctctagaaaa gctagaaaaa aaagaaattc ctacccttaa
     5221 tgatagtcgt tatgccttga ttgagtttag catgcatact tcctatcgtc agattcatac
     5281 gggattgagc aatattttga tgttgggaat cacgccagta attgctcata ttgaacgtta
     5341 tgatgcttta gagaataacg aaaaacgtgt tcgtgaactg attgatatgg ggtgctatac
     5401 tcagataaat agttatcatg tttcaaaacc taagttcttt ggtgaaaaat ataaattcat
     5461 gaaaaagaga gctcggtatt ttttggaacg tgatttagtt catgtagttg caagtgacat
     5521 gcacaattta gacagtagac ctccatatat gcaacaggca tatgatatca ttgctaagaa
     5581 atatggagcg aaaaaagtaa aagaactttt tgtagataat cccagaaaaa ttataatgga
     5641 tcaattaatt taggagaaaa tatgaaggaa caaaacactt tggaaatcga tgtattgcaa
     5701 ctattcagag ctttatggaa aagaaagttg gtcattttat tagtggcaat tataacttct
     5761 tcagttgctt ttgcctacag tacttttgtt atcaaacctg agtttactag tatgactcgg
     5821 atttatgtag ttaaccgtaa tcagggagag aagtctggtt taaccaatca agacttgcag
     5881 gcaggatcat ccttggttaa agactatcgt gaaattatcc tatcgcagga tgttttggag
     5941 gaagttgttt ctgatttgaa actagatttg acgccaaaag atttggctaa taaaattaaa
     6001 gtaacagtac cagttgatac ccgtattgtc tctgtttcag ttagtgatcg agttcctgaa
     6061 gaggcaagcc gtatcgctaa ctctttgaga gaagtagctg ctcaaaaaat tatcagtatt
     6121 actcgtgttt ctgatgtgac aacactggag gaggcaagac cggcgacatc accgtcttcg
     6181 ccaaatatta aacgcagtac actaattgtt tttttggcag gagtgattgg aactagtgtt
     6241 atagttctta ttcttgaact tttggacact cgtgtgaaac gtccgaaaga tatcgaagat
     6301 acactgcata tgacactttt gggaattgta ccaaacttga ataagttgaa ataggagaga
     6361 ggaatgccga cattagaaat agcacaaaaa aaactggagt tcgttaagaa ggcagaagaa
     6421 tattacaatg ccttgtgtac aaatatacag ttgagcggag ataaactaaa agtaatttcc
     6481 gttacttctg ttaaccctga ggaaggaaaa acaactactt ccgtaaatat agcaaggtcg
     6541 tttgcgcgtg caggctataa aactcttttg atcgatggcg atactcgaaa ttcagttatg
     6601 tcaggatttt ttaaatctcg tgaaaaaatt acagggctaa cggaattttt atctgggaca
     6661 gctgatttat ctcacggttt atgtgataca aatattgaaa atttatttgt agttcaatcg
     6721 ggcactgtat caccaaaccc tacagccttg ttacaaagta aaaattttaa tgatatgatt
     6781 gaaacattgc gtaaatattt tgattatatc attgttgata cagcacctat tggaattgtt
     6841 attgatgcgg caattatcac tcaaaagtgt gatgcgtcca tcttggtaac agcaacaggt
     6901 gaggtgaata aacgtgatgt ccaaaaagcg aaacaacaat tagaacaaac agggaaactg
     6961 ttcctaggag ttgttttgaa taaattagat atctcggttg ataagtatgg agtttacggt
     7021 ttctatggaa attatggtaa aaaaataatt taggaaagat tctatggatg aaaaaggatt
     7081 gaaaattttt ttggcagtat tacagagtat tattgtcatt ttattggttt attttcttag
     7141 ctttgttaga gagacagaac ttgaacgttc ttcgatggtt atactatacc ttctccactt
     7201 ttttgtattc tattttagtt cctatggtaa caattttttt aaaagagggt acctagttga
     7261 gtttaatagt accataagat atattttttt ctttgcaata gctataagtg tattaaactt
     7321 ttttatagcg gaacggttta gtatctctag aagaggaatg gtatacttct taactttaga
     7381 aggaatatcc ttatacttgt taaatttctt agtaaagaaa tattggaagc atgtgttttt
     7441 taatctaaaa aatagcaaga aaattttact gttaacagta acgaaaaata tggaaaaagt
     7501 tcttgataaa ttgctagaat ctgatgaact ttcatggaaa ttggtagcag taagtgtttt
     7561 ggataaatct gattttcaac atgataaaat acctgtaatt gaaaaggaaa aaattattga
     7621 atttgcaacg catgaagttg tggatgaggt gtttgtcaat cttccaggag agagctacga
     7681 tattggagaa attatctcta ggtttgagac aatggggata gatgtaactg taaatcttaa
     7741 agcatttgat aagaatttgg gtcgcaataa acaaattcat gagatggtag gattgaatgt
     7801 agtcactttc tctacaaatt tttataaaac tagtcatgta attgctaagc ggattattga
     7861 tatcatgggt gcattggtag ggctgatact atgtggttta gtcagtattg tattggttcc
     7921 tttgattcga aaggatgggg gctctgctat ttttgctcag acgcgtatag gaaaaaatgg
     7981 tcgtcagttc actttttata agtttcgctc tatgtgtgta gatgccgagg cgaaaaaaag
     8041 agaactcatg gaacaaaata ccatgcaggg tggaatgttt aaggtggacg atgatcctcg
     8101 tatcacgaaa attggtcgtt ttatacggaa gactagcttg gacgagttac cacagtttta
     8161 taatgttcta aagggagata tgagtttggt tggcacacgg ccacctacag tggacgagta
     8221 tgttcagtat acttcagaac agaaacgtcg actcagcttt aaacctggta ttacaggttt
     8281 atggcaggtt agcggccgta gtaaaataac cgattttgac gatgttgtaa aattagatgt
     8341 ggcttatatt gataattgga caatctggaa agatattgaa attttgctta aaactgttaa
     8401 agttgtattt atgagagatg gagcgaagtg aggaatgagg gatagaatcc aacttttagg
     8461 tgtaacaatt gatttgctta cgatgaatga aacgatagat agtgtagaac aatatgtatt
     8521 agaaaaaaga ccactacact tgatgggggt gaatgctgat aaaattaatc agtgtcatac
     8581 agatgagaaa atcaaaaaaa tcgttaatga gtcaggaatc attaatgcgg atggagcatc
     8641 agttgttctt gcaagtaagt ttttaggaac gcctgttcct gaacgagtag cgggtattga
     8701 tttgatgcaa tgtcttttag agttgtcaaa taaaaaagga tattcagttt acttttttgg
     8761 agcaaaagaa gaagttttgc aagatatgct caaagtattt aagagagatt atccaaattt
     8821 gatagttatt ggacacagaa atggctattt ttctgaagag gatgaacaag ctattcaaga
     8881 agatattcgt gaaaagaacc ctgattttgt gtttattgga attacgtctc ctaaaaaaga
     8941 atatattatt caaaaattta tggatagtgg cgtcaattcg gtatttatgg gagttggcgg
     9001 tagttttgat gtcttgtctg gtcatatcca acgagcacct ctatggatgc aaaagtcaaa
     9061 tttagagtgg ttattccgtg tagctaatga gcctaaacgt ctctttaaac gttattttgt
     9121 agggaatatt tcattcatag gaaaagtttt aaaagcaaaa agaggtgtaa aatattgaac
     9181 cagacagaga tgattcgctt aattcaaaaa gttgaattag atgctataaa agagtttaaa
     9241 aaaatctgtg aagagaatga tatagatttt ttcctccgcg gtggtagtgt acttggtgcg
     9301 gtcaaatacg acggctttat tccatgggat gatgatatgg atatcgctgt ccctcgtgaa
     9361 gcatacgaca aacttccaag tgttttcaaa gatagaatta tcgctgggaa atatcaggtt
     9421 cttacttatc aatactgtga tacgttgcat tgctactttc ctcgactatt ccttttagaa
     9481 gatgaaagaa aacgtttggg cttgccacga aataccaatc taggattgca tttgattgat
     9541 atcattcctt tagatggagc accaaatcat tcggttttaa gaaagattta ctttggcaaa
     9601 gtatactggt atcgtttttt agcaagttta ggaacaactt atgttggcga ccatgtggat
     9661 atgcattcca ctaagcaaaa actaattatt ggtttcttta aaaaactagg atttgcaaaa
     9721 ctatttcctc aaaattctgt atacagacgc ttggataatc tctatagaaa gtatgattgg
     9781 aaaaagcaga agtatgcggg gactatcaat gcttctttat ttgctaaaga agttatgcca
     9841 gtagagattt ggggagaagg agtagagaag ccttttgagg ataccttctt taaagttcca
     9901 acggagtatg atcgctacct gaaaagactt tacggagaaa actatcttta cgaagagcct
     9961 agtgatgatg aaaagaaatc gcatttagga ggacactaat ttgttttgtt atattatttt
    10021 gcattacaaa gtcttagaag aaactatttc ttgtgttaaa tctataaaag aaggcaatta
    10081 taatgcaaag caaatcgtta ttattgataa tttctctaat aatggtactg gtgaaaaact
    10141 acaagagctt tatgaatcag atttagaaat tgatgttttg attaaccatg aaaatgctgg
    10201 ttttgctcgt ggaaataatg tggcttatca atttgctaag gaaaagtata accccgattt
    10261 catggttatc atgaataacg atattgagat agaaacagaa aattttgaaa aaattgtgac
    10321 agatatctat cgtgaggaaa aattccattt gctcgggcca gatatcttct cgactactta
    10381 ccaacttcac caaaacccaa aacggttgac acattatact tatggagaag ttaaagctct
    10441 aaatgaaaaa tttaaaaaag ggagccaagt tagtctagct ttaaaaatca aatgttggtt
    10501 gaaagctagt aaagttcttc gaacagcaat ctatcaaaat agacgtaaaa aaggatcagt
    10561 agactataga aaacaggtag aaaacccaat tcttcatggt tcttttattg tatattcgag
    10621 agattttatc gaaaaagagg agtatgcttt taaccctaac accttctttt actatgaaac
    10681 agagatatta gattatgaag ctgaattaaa aggatacaag agaatttata cacctaaaat
    10741 tagagttttg caccatcaaa atgttgcaac taatcaagtt tacacgaact tgttagaaaa
    10801 aaccttgttt tcaaataaat gcaactttaa atccaccagt tattttttga agttgatgaa
    10861 agaaaacgag gatgtttaaa tgagttattt atttttactt tgccttacat tattcttatt
    10921 gactatattc tatttctttg cttttattca agatttaatt gctcctccag tagttatgtc
    10981 tgtaatgttt ctaattagtt cagtatttgc actggttaat tcaaaaaact ggaatattga
    11041 atatagtgga atagcctata ttctcataat tagtggtatt attatatttt cgattccttt
    11101 aatggcatta aaatcaccta attttaatac tgaggttaag attgctgatc gattaattga
    11161 tatccaattt tggaaaattg ctctaactat tataattgat ctctttattt tgtatcttta
    11221 caggaaggaa atatacaacc ttgttcttag taatggatat acggggtcaa atattcagtg
    11281 gttttttaga aatgcaacga gttatgaagg tgaattgaca gtgcgaactt ttattcgagt
    11341 tctcattcgt gttattgacg tatctgctta tatttttgga tatactttta ttaataattt
    11401 tcttatctat cgccataaac gccctaaaga catattactt ttagtacctt tattaatatt
    11461 tatttcaaaa actttaatat caggaggccg gcaagatatt attaaaattc tgattgccta
    11521 tgtaatcatg atgtatatcc aacaaaaacg gaaagttgga tggaatagag tcatatctca
    11581 taaatatatt caccttggat ttgttggttt aatagcaggt attccagcat tttactactc
    11641 tttgttttta gccggtcgtt caacgactag gacgctattt gagagtgttt cgacctatct
    11701 aggaggctca attcagcatt ttaatcagta tattgaaaat ccattagatc ctggtgaagt
    11761 ttttggcagt gaaacattgg tgcctatatt aaatatatta ggggaaatgg gcctagttaa
    11821 ttatcgtagt acaattcatt tagaatttcg gacactagga gttactgtag gaaatgttta
    11881 tacttttttt agaagaccct tgcatgattt tggtctagtt ggtatgtatg tatttgtctt
    11941 tgctgtaggt gctttttttg ctatttatta tttagttctg agaaagaaac aggttggttt
    12001 taatttggat attcatacca ttatttattc ttatgtcttt tattggattt ttttatcatc
    12061 aatcgagcaa tactcgttca caatgattag tctatataca cttgtattta ttgtgttggt
    12121 ttactttatg gctatctttt actggtgtac agattttaaa agaggaaaac tgatttttaa
    12181 aatttctgac tcaagtatca aattaaaaga agaataacag aatgtatagg agagggtaga
    12241 tgaatactaa aattaaaaat ataataacta gtttttctta tgttatttct tcaaatctgc
    12301 tcatagtttt aacctcatca ctagttgttt tgatttttcc taaaataatg ggggtaactg
    12361 agtacagtta ctggcaactt tatatttttt atctgaccta tatcggtttt ttccacttgg
    12421 gttggattga tgggatttat ctcaaatatg gtggcttaga atatacaaat ttagatagaa
    12481 aacagtttta ttctcagatg attctatttt ctagtttctt aatgctaatc tcgctggtat
    12541 tatttacttt gaacctaata actgtaaggg atgaaaacgc aagatatatt tataatatgg
    12601 ctatcattag catgatagtc acaaacttaa gaacactcta tgtttatatc ttgcagatga
    12661 caaatcgctt gaaggatagt tcagtcattc taattagtga tcgcgtttta tatgtactcc
    12721 ttttattcat gtttattgta tttggatggc atgagtacaa ggtcatgatt tgggctgata
    12781 ttctaggtcg aacattttct ctcatgcttt ccttctggat ttgtaaagat attgtgtttc
    12841 agcctttgtc aaaatttatc ttagatttca aggagtccct tgataatatc cgtgttggaa
    12901 tcaatttaat gctatctaac attgcgagta gcatgattat aggcattgtt cgtatgggaa
    12961 ttcaatggaa ttggaatatt gaaacattcg ggaaagtgtc attaactttg agtatatcta
    13021 atttattaat gacttttatt aatgccattg gattagttat ctttcctttg ataaagcgaa
    13081 caaagactga gaatttacct aaaatttatt ctaatttaag aaatgctttg atgttggtta
    13141 tgttcgcaat cttgctcttc tactatcctt taaaatttat tcttgatatt tggcttcctg
    13201 cttataagga tgccttagtt ttcatggccc taatttttcc tatgtcagtt tatgaaggga
    13261 aaatggcttt ggtgataaat acatatttaa aagcaatgag aatggaaaaa gacattctca
    13321 aaattaatgc tttggttatg ttaactagta tagtagtgac attagtgact actatactac
    13381 taaataattt ggggctgaca gttgtatcta tagttatttt acttgcttta agaagtataa
    13441 tagctgaatt aattttatcc aaaaaactga agatatcagt caagcaagac attgctttag
    13501 agttacttat gacgattata tttatttctt caagttggta tctctctatt tggattgcag
    13561 taataattta tttattggcg tatactttat atttgtattt aaagcacaaa gatatcagaa
    13621 tgtatataga atactttaaa aatcataaaa aaatatcata aaaattatat atcaatgaaa
    13681 tggtagatta catttctacc tttttatcca tttaggagga aacgatgaaa aagataatgc
    13741 tagttttcgg tacacgtcca gaagcaataa aaatgtgttc attagtcaat gagttgagaa
    13801 aacaggaaga tatgaaaaca gttgtttgtg taactggtca acacaaggag atggttagcc
    13861 ctgttttaga tttatttgga gttcaaccag actatgattt agaaattatg aaggctaatc
    13921 aaaacttgtt ctctataaca ataagtattt tagaaaaaat aaaacctgtg ttagaaaaag
    13981 aacaaccaga tattgttttg gttcacggtg atactactac gacatatgca gcagctttag
    14041 cggcatttta tctaggaatt aaagttggtc atgttgaagc tggattacga acttacaacc
    14101 tgcaaagtcc tttcccagaa gagttcaaca gacaatcgac ttctattatt gcaaattatc
    14161 attttgctcc tacagaatta gctaaagaaa atctaataaa agagggtaga aataatatct
    14221 atgttactgg aaatacagtg attgatgcac ttacaactac agtacaaaag gattatacac
    14281 accccgatct agatttaaac gatggaaatc gcctcatctt attgactgct catagacgcg
    14341 aaaatctcgg agaacctatg agacatatgt ttagagctgt taaacgagtt ttaaatgaat
    14401 atgacgatgt taaagtaatt tatccaattc ataaaaatcc attggtacgg gaaacagcta
    14461 cagaaatttt tggagataca gaacgtattc agatcattga acctttagat gttcttgatt
    14521 ttcacaactt tatgaatcat agttatatga ttctaactga ctcaggaggg gttcaagaag
    14581 aggcaccttc gttaggaaag cctgtattgg tcatgcgaga tacgacagaa agacctgaag
    14641 gagtagctgc tggaacgttg aaattggttg ggactgatga ggagactatt tatcaaaact
    14701 ttaagatgct tttagacgat cccgaagaat ataaaaaaat gagtcaagct agtaatcctt
    14761 atggaaatgg tgatgctagt aaacagattg ttcgaatttt acgtggaatt tgagtgtgtt
    14821 cagataaagt aatatagaaa ggtaccctac tatgaaaggt attattctag caggtggttc
    14881 ggggacacgt ttatatcctt tgactcgcgc tgcatcaaaa caacttatgc cggtttatga
    14941 taaaccgatg atttactacc cactttcaac attgatgttg gctgggatta gggatatttt
    15001 gattatttcc actccacagg atttacatcg attccaagag cttcttcaag acggatctga
    15061 gtttgggctc aaactttctt atgcagagca accaagtcca gatggtttgg cacaagcctt
    15121 tatcattggg gaagagttta tttctgatga tagcgttgcg ctgatcttag gtgacaatat
    15181 ctatcacggt tctgggcttt ccaagatgct acaaaaggca gcgagtaagg agtcgggagc
    15241 aactgttttt ggctaccatg tcaaggatcc agagcgcttt ggtgtggttg agtttgatca
    15301 ggatatgaag gctatttcta ttgaagaaaa gccagagcaa cctcgttcaa actatgcagt
    15361 tacaggtctc tatttctatg ataatgatgt agtagagatt gccaagagta ttaaaccaag
    15421 tcctcgtggt gaactggaaa ttacagatgt aaacaaggct tacctagatc gtggtgattt
    15481 gtctgttgag cttatgggac gtggctttgc ttggctggat actggaactc atgaaagttt
    15541 actagaggct tcacagtaca tcgaaacagt gcaacggatg caaaatgttc aggtagcaaa
    15601 cttagaagaa attgcttacc gtatgggcta tatcagtcga gaagatgtat tggccttagc
    15661 ccaaccactt aagaaaaatg aatacggaca gtatctgctc cgtttgattg gagaagcata
    15721 gatgacagat aattttttcg gtaagacgct tgcggcacgc aaggttgaag ctattccagg
    15781 catgttggag tttgatatcc ccgttcatgg agataatcgt ggctggttta aagaaaattt
    15841 ccaaaaggaa aaaatgcttc cacttggatt tccagagtct ttctttgcag aaggaaaatt
    15901 gcaaaacaat gtatccttct cacgtaaaaa tgtccttcga ggtctccacg cagagccttg
    15961 ggataagtac atctctgtag cagatggagg gaaagttctg ggttcttggg ttgatctacg
    16021 cgagggtgaa acctttggga atacctatca gacagtgatt gatgcgagta agggaatctt
    16081 tgttcctcga ggcgtagcta atggctttca agttttatca gatacagtgt catatagcta
    16141 tctggtcaat gattactggg ctcttgaact caaacccaag tatgcctttg tgaactacgc
    16201 tgatccaagc cttggtattg aatgggaaaa tattgcagaa gcagaggttt cagaagcaga
    16261 caaacatcat ccactactta aggatgtaaa acctttgaaa aaagaagatt tggaataagg
    16321 aaagaatatg actgaataca aaaatattat cgtgacaggt ggagctggct ttatcggttc
    16381 taactttgtc cattatgttt acgagaactt tccagatgtt catgtgacag tcctagataa
    16441 gttgacttat gctggaaacc gcgcgaatat tgaggaaatt ttaggtaatc gtgttgagtt
    16501 agttgttggt gacattgctg atgcggagtt ggtagacaag ttggctgctc aagcagatgc
    16561 tatcgttcat tatgcagcgg aaagccacaa tgataattcg ctcaatgatc catcgccatt
    16621 tattcatact aacttcatcg gaacctatac tcttttagaa gctgctcgta agtatgatat
    16681 tcgcttccac catgtatcga cagatgaagt ttatggggat ctccctttac gcgaagattt
    16741 gccaggtcat ggtgaaggac caggtgagaa atttactgct gaaacaaaat acaacccaag
    16801 ctctccgtac tcatcaacca aggcagcctc agatttgatt gtcaaagcct gggtgcgttc
    16861 ttttggagtc aaggcaacga tttccaactg ttcaaataac tacggtcctt atcaacatat
    16921 cgaaaaattc atcccacgtc agattactaa catcctaagt ggtatcaagc caaaacttta
    16981 cggtgaaggt aagaacgttc gtgattggat tcataccaat gaccattctt caggagtttg
    17041 gacaatcttg acaaaagggc aaatcggtga aacctacttg attggggctg atggtgagaa
    17101 gaacaataag gaagttttgg aacttatcct taaggaaatg ggacaagctg cggatgccta
    17161 tgatcatgtg actgaccgtg caggacatga ccttcgctat gcgattgatg ctagcaagct
    17221 ccgtgatgag ttggggtgga aacctgaatt taccaacttt gaagctgggc tcaaggcaac
    17281 aatcaagtgg tatacagata accaagaatg gtggaaagca gagaaagaag ctgttgaagc
    17341 caattatgct aagactcagg agattattac agtataaaaa gcaggaaata gctgcttttt
    17401 attgctatat tgggaagagt tacatattag aaaggtctag agatgatttt aattacaggg
    17461 gcaaatggcc aattaggaac ggaacttcgc tatttattgg atgaacgtaa tgaagaatac
    17521 gtggcagtag atgtggctga gatggacatt accgatgcag aaatggttga gaaagttttt
    17581 gaagaggtga aaccgacttt agtctaccac tgtgcagcct acaccgctgt tgatgcagca
    17641 gaggatgaag gaaaagagtt ggacttcgcc atcaatgtga cggggacaaa aaatgtcgca
    17701 agagcatctg aaaagcatgg tgcaactcta gtttatattt ctacggacta tgtctttgac
    17761 ggtaagaaac cagttggaca agagtgggaa gttgatgacc gaccagatcc acagacagaa
    17821 tatggacgca ctaagcgtat gggggaagag ttagttgaga agcatgtgtc taatttctat
    17881 attatccgta ctgcctgggt atttggaaat tatggcaaaa acttcgtttt taccatgcaa
    17941 aatcttgcga aaactcataa gactttaaca gttgtaaatg accagtacgg tcgtccgact
    18001 tggactcgta ccttggctga gttcatgacc tacctagctg aaaatcgtaa ggaatttggt
    18061 tattatcatt tgtcaaatga tgcgacagaa gacacaacat ggtatgattt tgcagttgaa
    18121 attttgaaag atacagatgt cgaagtcaag ccagtagatt ccagtcaatt tccagccaaa
    18181 gctaaacgtc cgctaaactc aacgatgagc ctggccaaag ccaaagctac tggatttgtt
    18241 attccaactt ggcaagatgc attgcaagaa ttttacaaac aagaagtgag ataagtagta
    18301 gaatgatttt ctagtctaat aaaagaggca gataatgaac tccaaaggag cttaagatgt
    18361 acgattatct tgttgttggt gctggtctct ttggcgcata gctttggctc agtttctatt
    18421 atcgctcaca ccatccatca gaagtttaat ctgaaggtac ccaattatcg ccaagaagaa
    18481 gattgggcta ggatgggttt accaatcaca cgtaaggaaa tctctaattg gcatatcaag
    18541 gcaagtcaat actatttaga gtccctttat aaccttttac gagaaaagtt gttagaacaa
    18601 cctcttcttc atgcggatga aacctcttat cgggtcttag aaagtgatag tcagctgacc
    18661 tactattgga cctttttgtc tgggaaagct gagaatcaag taatcacgct ttaccaccat
    18721 gatcagtgtc ggagtggttc ggtagtgcaa gaattcctag gagattattc tggctatgtg
    18781 cattgtgata tgttgcggca gtaacttagg actttagtcc tctagttctg tctatgcgat
    18841 agcagtccaa ggtttaggag caaggcgacg ctaagcttgg taaactgcga accgctagaa
    18901 gcttatcgtc aactggaaga agctgaactt gttggatgtt gggcgcatgt gagaaggaaa
    18961 ttttttgaag tgccccccaa gcaagcagat aaatcatcct taggagctaa aggtttagct
    19021 tattgtgatc agttattttc cttggaaaga gactgggagg ctttgccagc tgatgaacga
    19081 ctacagaaac gtcaagaaca tctccaaccc ctaatggaag acttctttgc ttagtgccgt
    19141 cgtcagtcag ttttatcggg ttcaaaacta ggaagggcaa ttgaatacag cctcaagtat
    19201 gaagaaacct ttaagaccat tttaaaagac ggacatctgg tcctttccaa taatctagct
    19261 gaacgcgcca ttaaatcatt ggttatggga cggagtaaaa gagtccagtg gactctttta
    19321 gcctaagcta aattttaaaa agcgagggtg gttattttct caaagttttg aaggagctaa
    19381 agcaagagct attattatga gcttattgga aacagctaaa cgtcatcaac taaatagtga
    19441 gaaatatcta tcctatcttc tagaatgtct tccaaacgag gaaactctcg taaacaaaga
    19501 ggttttagag gcctatttac catggactaa agttgtacaa gaaaagtgca aataagaaat
    19561 ctccagatta ggaactatcc gtgagttcac taatctggag atttttcaat agacctcgtt
    19621 attgggcggt tacgatattc atattttttg caaagatgtt gtttgaaaaa taattttcaa
    19681 aaattctgaa aattctgttg acatctttct gaaaagagtc tataatggag agaaagtttt
    19741 aaaggagaaa atgatgaaaa gttcaaaact acttgccctt gcgggcgtga cattattg
//
