LOCUS       CR931633               20602 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain pn2L (serotype 2).
ACCESSION   CR931633
VERSION     CR931633.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20602)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 20602)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..20602
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="pn2L"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC02_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC02_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI32716.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            294..459
                     /gene="aliB"
                     /locus_tag="SPC02_0002"
                     /pseudo
     CDS             294..459
                     /gene="aliB"
                     /locus_tag="SPC02_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(460..1101,1103..1429))
                     /gene="tnp"
                     /locus_tag="SPC02_0003"
                     /pseudo
     CDS             complement(join(460..1101,1103..1429))
                     /gene="tnp"
                     /locus_tag="SPC02_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(join(1039..1101,1103..1411))
                     /gene="tnp"
                     /locus_tag="SPC02_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 7.7e-24"
                     /pseudo
     gene            1653..3107
                     /gene="wzg"
                     /locus_tag="SPC02_0004"
     CDS             1653..3107
                     /gene="wzg"
                     /locus_tag="SPC02_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI32719.1"
                     /db_xref="GOA:Q4K376"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K376"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSLSVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIELEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNVPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1653..1778
                     /gene="wzg"
                     /locus_tag="SPC02_0004"
                     /note="Signal peptide predicted for SPC0032 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 42 and 43"
     misc_feature    1866..2213
                     /gene="wzg"
                     /locus_tag="SPC02_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.6e-63"
     misc_feature    2391..2834
                     /gene="wzg"
                     /locus_tag="SPC02_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            3109..3840
                     /gene="wzh"
                     /locus_tag="SPC02_0005"
     CDS             3109..3840
                     /gene="wzh"
                     /locus_tag="SPC02_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI32720.1"
                     /db_xref="GOA:Q4JZ01"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ01"
                     /translation="MIDVHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTPDVLDKLGKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMSGITPVIAHIERYDALGNNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    3112..3720
                     /gene="wzh"
                     /locus_tag="SPC02_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.5e-36"
     gene            3846..4541
                     /gene="wzd"
                     /locus_tag="SPC02_0006"
     CDS             3846..4541
                     /gene="wzd"
                     /locus_tag="SPC02_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI32721.1"
                     /db_xref="GOA:Q4JZ00"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ00"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILLVALVTGAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQGDKSGLTNQDLQAGSYLVKDYREIILSQDALEKVATNLKL
                     DMPAKTLASKVQVTVPTDTRIVSISVKDKQPEEASRIANSLREVAVEKIVAVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELFDTRVKRPEDIEDVLQI
                     PLLGLVPDLDKMK"
     misc_feature    3846..3962
                     /gene="wzd"
                     /locus_tag="SPC02_0006"
                     /note="Signal peptide predicted for SPC0034 by SignalP 2.0
                     HMM (Signal peptide probability 0.721) with cleavage site
                     probability 0.467 between residues 39 and 40"
     misc_feature    3867..4283
                     /gene="wzd"
                     /locus_tag="SPC02_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1e-55"
     misc_feature    4389..4466
                     /gene="wzd"
                     /locus_tag="SPC02_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4551..5231
                     /gene="wze"
                     /locus_tag="SPC02_0007"
     CDS             4551..5231
                     /gene="wze"
                     /locus_tag="SPC02_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI32722.1"
                     /db_xref="GOA:Q4K373"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K373"
                     /translation="MPTLEISQAKLDFVKKAEEYYNSLCTNLQLSGDGLKVFSITSVK
                     LGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GDYGKNKK"
     gene            5246..6613
                     /gene="wchA"
                     /locus_tag="SPC02_0008"
     CDS             5246..6613
                     /gene="wchA"
                     /locus_tag="SPC02_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32723.1"
                     /db_xref="GOA:Q4K372"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K372"
                     /translation="MNGKTVKSSLAIIQSFLIILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYCKRAYLNFKGSKKILLLTATSRVEKVLDRLIESNEVVGEL
                     VAVSVLDKSDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFGCSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQVYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    5246..5338
                     /gene="wchA"
                     /locus_tag="SPC02_0008"
                     /note="Signal peptide predicted for SPC0036 by SignalP 2.0
                     HMM (Signal peptide probability 0.861) with cleavage site
                     probability 0.343 between residues 31 and 32"
     misc_feature    6029..6610
                     /gene="wchA"
                     /locus_tag="SPC02_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 9.5e-158"
     gene            6645..7829
                     /gene="wchF"
                     /locus_tag="SPC02_0009"
     CDS             6645..7829
                     /gene="wchF"
                     /locus_tag="SPC02_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32724.1"
                     /db_xref="GOA:Q4K371"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K371"
                     /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTEYQKDGNIQYYVACIR
                     ENSAKSGFTADTFEYNGAICYNIDVPNIGPARAIAYDIAAVNKAIELAKGNKDEAPIF
                     YILACRIGPFISGLKKKIRSIGGRLLVNPDGHEWLRAKWSLPVRKYWKFSEQLMVKHA
                     DLLVCDSKNIEKYVREDYKQYQPKTTYIAYGTDTTPSSLKSEDAKVRNWYREKGVSEN
                     GYYLVVGRFVPENNYETMIREFMKSNSKKDFVLITNVEQNKFYDQLLKDTGFDKDPRV
                     KFVGTVYDQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTRLNLLLDVGFNREVGE
                     NGAIYWRKDELARVIEAVEQFDENAISELDKKSSQRIAEAFTWEEIVVDYEEEFEGGK
                     SE"
     misc_feature    7263..7766
                     /gene="wchF"
                     /locus_tag="SPC02_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.0027"
     gene            7846..8766
                     /gene="wchG"
                     /locus_tag="SPC02_0010"
     CDS             7846..8766
                     /gene="wchG"
                     /locus_tag="SPC02_0010"
                     /note="member of homology group 133"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32725.1"
                     /db_xref="GOA:Q4K370"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K370"
                     /translation="MMATYNGAKYIGEQIDSILRQTYQDWKLFIHDDCSNDATFQILQ
                     QYQEKYPKKIKVITDSSVIGGSSEKNFAAIQKWVTNNHDFSYFMFADQDDFWFPNKIE
                     RSLYKMKESEKDDLPILVHTDLEVVDDNLNIINDSFFEYRALDVDVTELNRILIQNNI
                     TGCTMLWNRSLNNLLDLNSNAVAMHDWWISLVAASFGKIVCLKEPTIKYRQHGGNVVG
                     ATQVNTLGFIIKRLLGNSHVKETLKLSFEQAESFLKVYQNSLSNEETDIIREFISIPH
                     KHKLARISTVIKGGYLKQSVVQVIGELMFI"
     misc_feature    7846..8370
                     /gene="wchG"
                     /locus_tag="SPC02_0010"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 3.3e-12"
     gene            8815..9828
                     /gene="wchH"
                     /locus_tag="SPC02_0011"
     CDS             8815..9828
                     /gene="wchH"
                     /locus_tag="SPC02_0011"
                     /note="member of homology group 134"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32726.1"
                     /db_xref="GOA:Q4K369"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K369"
                     /translation="MTGGIRVIYTYANYLIDQGHDVVCYVPMISYRGRNQTIFYRIKA
                     SLGNTLKNDNWFDKKFDLKRIPVVSEKYIRDADVVIATAWQTAYDVANFSSSKGHKFY
                     FIQDYEIFNGGKEEVEASYRLPLTLITVTRSLKKAIQKFTDKTIYVVYNGLSDNEYLH
                     TEKISHKDLTLMMMYHESEHKKSQEGLQIIAKLKKRYPDMKINIFGRRIPEKLPDTYN
                     VLINPEREKILKMYQESDVYLFTSEIEAWGLPIVEAMANKCAVVGRSRGALLELSNGQ
                     NTIVVEELSEIYNKVVHLQEDRLLLAQVQNEGYKTVIPLNWSNSCLEFEKIISGVYIE
                     NGK"
     misc_feature    9280..9747
                     /gene="wchH"
                     /locus_tag="SPC02_0011"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.00011"
     gene            9869..11032
                     /gene="wzy"
                     /locus_tag="SPC02_0012"
     CDS             9869..11032
                     /gene="wzy"
                     /locus_tag="SPC02_0012"
                     /note="member of homology group 135"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI32727.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K368"
                     /translation="MLSLYTGNGVTPVIVILFFLSALYSLYRKSKLSINLNFLFIYIF
                     LAYYLLLTVIFTQDLLVMTSKFILFPIFVYYIIPKNINGVIRILSIFKSFIGFTAIFG
                     LYEYMQHFNLMVNFVKIDAVKWIQTMNLNSVYYPSSIFLHYTYFAYVLLLAFILVIVI
                     PYKNRVLNLVYKTLIAISIFLPQSRIVWIAFGVILILSFILNRQGILTYRKLSVIVLI
                     LIIVVSLCLYFDVFAFISNYISLRFSSLYRYGLADGSLGQRIGTLRNWENYLDSDTIK
                     AIIGSGFGGVNSYLSTYSFFNGYTTADSTVTSFLIDTGVIGLFIFLLSMFQILVIVVK
                     GKGIFRELALYTIVASSIVSLTIDFWANYVILHIFYVVIICAFIGMRLTKQEK"
     gene            11162..12319
                     /gene="wchI"
                     /locus_tag="SPC02_0013"
     CDS             11162..12319
                     /gene="wchI"
                     /locus_tag="SPC02_0013"
                     /note="member of homology group 136"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32728.1"
                     /db_xref="GOA:Q4K367"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K367"
                     /translation="MTKSILYFLSTSDISSGATRSLLRLVSIVEDSDFRVIIILPEHG
                     NVEDELVNKGIKYYVVKQYIWNYWIKYLSHTKNIFYYLKLPLKYLLNRISFHKINRII
                     KKEKVDIIHMNTLTSFLGAQAAIKQRKILIWHIREFMEEDLGIEFCNRKKAIDLINKS
                     TCVISISDSISKNFSNEVLAYKKVIHNGLSIDDYFIDKVAFQNQKINILSSGRITPGK
                     GQVDLVRAIANLPERYKQMFKVDIIGIVESEEYFKEIKEVISNYKLDGIEFHGFQSDP
                     TDFFRKCDIVCVCSKKEAFGRITVEGMLSGALVIGTNSGGTKEIISTGETGYLYEPGD
                     YMQLSEILKTIINNRSSILEIALRGQEKATLRFSDKNNAMQIMQLYKELEN"
     misc_feature    11735..12247
                     /gene="wchI"
                     /locus_tag="SPC02_0013"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.5e-34"
     gene            12316..13725
                     /gene="wzx"
                     /locus_tag="SPC02_0014"
     CDS             12316..13725
                     /gene="wzx"
                     /locus_tag="SPC02_0014"
                     /note="member of homology group 111"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI32729.1"
                     /db_xref="GOA:Q4K366"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K366"
                     /translation="MSRRYNYLLKNIGLLTLSNFGSKILVFLMVPLYTSVLSTSDYGT
                     YDLFNTTISLLIPIISINISEGVLRFALDEKNDSSIVYSIGWNIIIKGFLVVVLGIIF
                     NNIFNIFPLLKENSITFLLLYLSTIVYQFLSSFIRGIDKVSILSIAAILNTISILGFN
                     ILFLIIIPLGLVGYFWSNILGLVLPSLYLIYKISQYNIKYTSLQNKKLQQRLVSYSIP
                     LILNSLGWWINNAIDRYVVIAFCGVAVNGIYSVGYKIPSILNIFANIFNQAWILSSVK
                     SYRDEDSEYFFSQVYNKYNMIMVLISGLLISCSKILAKFLYMNEFYDAWKFVPFLLIA
                     NVFGAISGFAGGIFSAVKDSKIYSQSTLVGAIVNIIFTFVFVYYYGAIGAAIATMISY
                     FVVWIIRVHTMRKYIKLKIFIRRDVFSYVLLIFQSIVLWLENSYILYPIQVVLFLLLV
                     MLFYKEIKSIIGELKKFLT"
     misc_feature    12337..13149
                     /gene="wzx"
                     /locus_tag="SPC02_0014"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 2e-24"
     gene            13761..14999
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
     CDS             13761..14999
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
                     /note="member of homology group 20"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase Ugd"
                     /protein_id="CAI32730.1"
                     /db_xref="GOA:Q4K365"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR014028"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="UniProtKB/TrEMBL:Q4K365"
                     /translation="MKIAVAGTGYVGLSIAVLLSQQHQVMAVDIIPEKVELINQRKSP
                     IQDDYIEKYLAKKDLNLVATLDAKEAYQDADFVVIAAPTNYDPKKNFFDTSAVESVIE
                     TALKYNPDAIMVIKSTVPVGYTESARKKFQTENILFSPEFLRESKALYDNLYPSRIIL
                     GTDKNNERLVSAAETFARLLQEGALKENIDTLYMGFTEAEAVKLFANTYLALRVSYFN
                     ELDTYSEMKGLDTQAIIDGVGLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYEDIPE
                     ELIGAIVRSNSTRKDFIADQVLKMVDYYDYSAHNIFDERVEKDIIIGIYRLTMKSNSD
                     NFRQSSIQGIMKRIKAKGVRVVIYEPTLESGSTFFGSSVINDLEEFKRLSNAIVANRY
                     DNSLEDVKEKVYTRDIFERD"
     misc_feature    13761..14273
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
                     /note="HMMPfam hit to PF01210, NAD-dependent
                     glycerol-3-phosphate deh, score 0.00015"
     misc_feature    13761..14315
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
                     /note="HMMPfam hit to PF03721, UDP-glucose/GDP-mannose
                     dehydrogenase, score 5.4e-51"
     misc_feature    14346..14627
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
                     /note="HMMPfam hit to PF00984, UDP-glucose/GDP-mannose
                     dehydrogenase, score 2.8e-38"
     misc_feature    14727..14978
                     /gene="ugd"
                     /locus_tag="SPC02_0015"
                     /note="HMMPfam hit to PF03720, UDP-glucose/GDP-mannose
                     dehydrogenase, score 3.7e-06"
     gene            15028..15633
                     /gene="glf"
                     /locus_tag="SPC02_0016"
     CDS             15028..15633
                     /gene="glf"
                     /locus_tag="SPC02_0016"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI32731.1"
                     /db_xref="GOA:Q4K364"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K364"
                     /translation="MLEAVHTEKQWERSATELPPFIIKRLPVRLTFDNNYFNDRYQVI
                     PIGGYNVIIENILKDVEVGLGVDCFDYREELEASANKVAFTGMIDQYFDYKHGELEYR
                     SLRFKHEVLDEENHQGNAVVNYTDREIPYTRIIEHKKFEYGLQPKTVITHEYPADWKR
                     GDEPYYPINDEKNNAIFSKYHEEASQNDKVIFCGRLADYKY"
     misc_feature    15028..15630
                     /gene="glf"
                     /locus_tag="SPC02_0016"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 3.2e-138"
     gene            15711..16580
                     /gene="rmlA"
                     /locus_tag="SPC02_0017"
     CDS             15711..16580
                     /gene="rmlA"
                     /locus_tag="SPC02_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI32732.1"
                     /db_xref="GOA:Q4K363"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K363"
                     /translation="MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLA
                     GIKDILIISTPQDLPRFKDLLLDGSEFGIRLSYAEQPSPDGLAQAFLIGEDFIGDDSV
                     ALILGDNIYHGPGLSKMLQKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
                     PECPRSNYAVTGLYFYDNDVVEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKN
                     EYGQYLLRLIGEV"
     misc_feature    15714..16430
                     /gene="rmlA"
                     /locus_tag="SPC02_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 6.3e-118"
     gene            16581..17174
                     /gene="rmlC"
                     /locus_tag="SPC02_0018"
     CDS             16581..17174
                     /gene="rmlC"
                     /locus_tag="SPC02_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI32733.1"
                     /db_xref="GOA:Q4K362"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4K362"
                     /translation="MTDNFFGKILAVRKIDAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MEPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTIIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
     misc_feature    16614..17147
                     /gene="rmlC"
                     /locus_tag="SPC02_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 6.3e-16"
     gene            17187..18236
                     /gene="rmlB"
                     /locus_tag="SPC02_0019"
     CDS             17187..18236
                     /gene="rmlB"
                     /locus_tag="SPC02_0019"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI32734.1"
                     /db_xref="GOA:O54546"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54546"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    17202..18158
                     /gene="rmlB"
                     /locus_tag="SPC02_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00012"
     misc_feature    17205..17945
                     /gene="rmlB"
                     /locus_tag="SPC02_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    17208..18020
                     /gene="rmlB"
                     /locus_tag="SPC02_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.4e-05"
     gene            18302..19153
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
     CDS             18302..19153
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI32735.1"
                     /db_xref="GOA:O54665"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54665"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    18302..19150
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 3.4e-148"
     misc_feature    18305..18934
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 5.6e-19"
     misc_feature    18305..18946
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0001"
     misc_feature    18308..19036
                     /gene="rmlD"
                     /locus_tag="SPC02_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.8e-08"
     gene            order(19229..20139,20141..20356)
                     /gene="tnp"
                     /locus_tag="SPC02_0021"
                     /pseudo
     CDS             join(19229..19636,19636..20139,20141..20356)
                     /gene="tnp"
                     /locus_tag="SPC02_0021"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    join(19235..19636,19636..19674)
                     /gene="tnp"
                     /locus_tag="SPC02_0021"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 0.00033"
                     /pseudo
     gene            20555..>20602
                     /gene="aliA"
                     /locus_tag="SPC02_0022"
     CDS             20555..>20602
                     /gene="aliA"
                     /locus_tag="SPC02_0022"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI32737.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ89"
                     /translation="MMKSSKLLALAGVTLL"
BASE COUNT     6623 a   3180 c   4261 g   6538 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaggactgt ataaaagaca gaaatccttt gttttttata accaaggttt ataaactttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactattt aaggagaaag aagatgaaca
      301 taaagaagcg tgtccttagt gcaggcctga cttttgcatc tgctttgctt ttagctgctt
      361 gcggccaatc aggttcagat acaaaaactt actcatcaac ctttggtgga aatccaacta
      421 catttaacta tctattagac tattacgctg ataacatagt caattgaaac aagaacagga
      481 caaaagagcc tcgtaaaagg tatggcaact tggtaatacc tttttgaggt gctttttgat
      541 ataagcccat gttttctcaa taggattgta ctcaggtgag tagggaggaa gaggtaaaag
      601 tttatgccca gacccttcgc ataaaagttc tagcttcccc attctatgga atcttgcatt
      661 atccataata tagtagattg aaactagaat agtacacctc tacttctaaa acattgttag
      721 aattcgattt tactgtcctg atcgatttat cttattctta tttcatttta ctataataac
      781 cgatggtgtg gttaatgttg gtaagagaaa cttctgaaac catacttcaa aaaagtcgct
      841 cgtcatcgtc tcttcgtaag tcattggaac gattaattca ccatttatta gacctgcaac
      901 caaagaaatc ctctgatatc ttcttccaga tactttgcct cttcttaact gaccttttaa
      961 tgagcgacca tattctcgat aaaaataagt atcgaatcct gtttcgtcaa tctaaacagg
     1021 tgctaggtgc tttaaactat taaaattctt aagaaataag gctacttttt ctgggtcttg
     1081 ttcatagtag gtgtggttct ttttttcgag tgtagcccat agctttgagc gcatagtgga
     1141 tggtagttgg atgacagcca aattcagaag ctatttcagt caaataagcg tctggattat
     1201 tagtaagata gtttttaagt ctatctctat caacttttct tggttttgtt ccttttactt
     1261 ggtggtttag ctctcctgtt ttctctttta gctttaacca gccataaatg gtattacgtg
     1321 agatttggaa aacgtgtgat gcttctgtta tactacctgt tcgctcacaa taagagagaa
     1381 cttttttacg aaaatctatt gaatatgcca taaaaagatt ataccacatt gtgtactata
     1441 ttatattgaa actagaatag tacacatctg cttctaaaat attgttagaa aacgatttga
     1501 ctgtcctgat caatttgtca tgttcttatt tcattttact atatttttgg ttcgcgggaa
     1561 gtctactaag atacttaaag atgcagatag tgaaaaaagg tgtagacatt accgtaaaaa
     1621 agtgatataa tcgtaagatg ttcaatgtat aggtgttaat catgagtaga cgttttaaaa
     1681 aatcacgttc acagaaagtg aagcgaagtg ttaatatagt tttgttgact atttatttat
     1741 tgttagtttg ttttttattg ttcttaatct ttaagtacaa tatccttgct tttagatatc
     1801 ttaatctagt ggtaactgcg ttagtcctac tagttgcctt ggtagggcta ctcttgatta
     1861 tctataaaaa agctgaaaaa tttactattt ttctgttggt gttctctatc cttgtcagct
     1921 ctgtgtcgct ctttgcagtc cagcagtttg ttggactgac caatcgttta aatgcgactt
     1981 ctaattactc agaatattcg ctcagtgtcg ctgttttagc agatagtgag atcgaaaatg
     2041 ttacgcaact gacgagtgtg acagcaccga ctgggactga taatgaaaat attcaaaaac
     2101 tactagctga tatcaagtca agtcagaata ccgatttgac ggttaaccag agttcgtctt
     2161 acttggcagc ttacaagagt ttgattgcag gggagactaa ggccattgtc ctaaatagtg
     2221 tctttgaaaa tatcatcgag ttagagtatc cagactacgc atcgaagata aagaagattt
     2281 ataccaaggg attcactaaa aaagtagaag ctcctaagac gtctaagaat cagtctttca
     2341 atatctatgt tagtggaatt gacacctatg gtcctattag ttcggtgtcg cgatcagatg
     2401 tcaatatcct gatgactgtc aatcgtgata ccaagaaaat cctcttgacc acaacgccac
     2461 gtgatgccta tgtaccaatc gcagatggtg gaaataatca aaaagataaa ttaacccatg
     2521 cgggcattta tggagttgat tcgtccattc acaccttaga aaacctctat ggagtggata
     2581 tcaattacta tgtgcgattg aacttcactt ctttcttgaa aatgattgac ttattgggag
     2641 gggtagatgt tcataatgat caagagtttt cagctctaca tgggaagttc catttcccag
     2701 tagggaatgt ccatctagac tctgagcaag ctctaggttt tgtacgtgaa cgctactcac
     2761 tagccgatgg agaccgtgac cgcgggcgca atcaacaaaa ggtgattgtg gctatccttc
     2821 aaaaattaac gtcaaccgaa gcactgaaaa attatagtac gatcattaat agcttgcaag
     2881 attctatcca aacaaatgtg ccacttgaga ctatgataaa tttggtcaat gctcagttag
     2941 aaagtggagg aaattataaa gtaaattctc aagatttaaa agggacaggt cggatggatc
     3001 ttccttctta tgcaatgcca gacagtaacc tctatgtgat ggaaatagat gatagtagtt
     3061 tagctgtagt taaagcagct atacaggatg tgatggaggg tagatgaaat gatagacgtc
     3121 cattcgcata tcgtttttga tgtagatgac ggtcccaagt caagagagga aagcaaggct
     3181 ctcttggcag aatcctacag gcagggggtg cgaaccattg tctctacctc tcaccgtcgc
     3241 aagggtatgt ttgaaactcc ggaagagaag atagcagaaa actttcttca ggttcgggaa
     3301 attgcaaaag aagtagcaga tgatttagtc attgcttacg gggctgaaat ttactacaca
     3361 ccagatgttc tggataagct gggaaaaaag cggattccga ccctcaatga tagtcgttat
     3421 gccttgatag aatttagtat gaacactcct tatcgcgata ttcatagcgc cttgagcaag
     3481 atcttgatgt cgggaattac tccagtcatt gcccacattg agcgctatga tgctcttgga
     3541 aataatgaaa aacgcgttcg agaactgatt gatatgggct gttacacgca agtaaatagt
     3601 tcacatgtcc tcaaaccaaa actttttgga gaacgttata aattcatgaa aaaaagagct
     3661 cagtattttt tagagcagga tttggttcat gtcattgcaa gtgatatgca caatctagac
     3721 ggtagacctc ctcatatggc agaagcatat gaccttgtta cccaaaaata cggagaagcg
     3781 aaggctcagg aactttttat agacaatcct cgaaaaattg taatggatca actaatttag
     3841 gagaaatgat gaaagaacaa aacacgatag aaatcgatgt atttcaatta tttaaaacct
     3901 tgtggaaacg caagctaatg attttattag tggcacttgt gacaggtgcg ggggcttttg
     3961 catatagcac ttttattgtt aagccagaat atacgagtac cacgcgaatt tacgtagtga
     4021 atcgcaatca aggagacaag tcggggctga caaatcagga tttgcaggca ggatcttatc
     4081 tggtaaaaga ctaccgtgag attatccttt cgcaggatgc attggaaaaa gtagcgacaa
     4141 atttgaagtt ggacatgcca gcaaaaacgt tagctagcaa agttcaagtg actgtaccaa
     4201 ctgacactcg tatcgtctca atctctgtca aggataaaca gccagaggaa gccagtcgta
     4261 tcgctaattc tctacgagaa gttgctgtag aaaagatcgt cgctgtaacg cgagtatctg
     4321 atgtaacgac acttgaagaa gcgcgaccag ctacgactcc ttcttctcca aatgttcgac
     4381 gcaattcctt gtttggtttt cttggaggag cagtcgtaac agtaattgct gttcttttga
     4441 ttgagttgtt cgacacccgt gtgaaacgtc ctgaagatat tgaagatgta ctgcaaattc
     4501 cacttttagg gctcgttcca gatttggaca aaatgaaata ggaggaagtt atgccaacgt
     4561 tagaaatctc acaggcaaaa ttggattttg taaaaaaggc agaggaatat tataactctt
     4621 tgtgcacgaa cctacagtta agtggagatg gtttgaaagt attttctatc acttctgtga
     4681 aactaggaga aggaaaatca acgacttcca ccaatatcgc ttgggctttt gcgcgtgcag
     4741 gttacaaaac gctgctgatt gatggagata ttcgcaattc tgttatgtta ggtgtcttta
     4801 aagcaaggga taagattaca ggcctgacag aatttttatc aggaactaca gacctatcac
     4861 aagggctttg tgataccaat atcgaaaatc tctttgtaat tcaggctggc tctgtgtcac
     4921 cgaatccgac agctcttctt caaagtaaga atttcagtac aatgcttgaa accttgcgta
     4981 aatattttga ctacatcatt gtagatacag ctcctgtcgg tgtcgtgatt gatgcggcta
     5041 ttattacgcg aaaatgcgat gcttctattt tagtgacgga ggcaggtgaa ataaatcgac
     5101 gggatattca aaaagcaaaa gaacagttgg aacacacagg gaagccgttt ttgggagttg
     5161 tgttgaataa attcgatact tcagtagaca aatacggttc ttatggagat tacgggaaaa
     5221 ataaaaaata ggtcggggga tagagatgaa tggaaaaaca gtaaagtctt cattggccat
     5281 aatccagagt tttcttatta ttttattgac ttatctactt agtgctgtga gagaagcgga
     5341 gattgtttca acaacagcta ttgcacttta tatcctccat tattttgtct tttatatcag
     5401 tgattatgga caagatttct ttaaaagggg atatttgatt gaacttgtcc agacattgaa
     5461 atatatccta ttctttgcac tagcgattag tatttctaat tttttcttag aggatcgatt
     5521 tagtatttcc agacgaggca tgatttactt cctcacatta catgctctct tagtctatgt
     5581 gctaaaccta tttatcaagt ggtattgtaa gcgggcttat ctcaacttta aaggaagtaa
     5641 gaagattctc ctacttacag caacttctcg tgtcgaaaag gtactggata gattaataga
     5701 atcaaatgag gttgttgggg agttggtagc cgtcagtgtc ttagataaat cagattttca
     5761 gcatgattgt ttaaaggtag tagcagaggg ggagatagta aactttgcga ctcatgaggt
     5821 ggtcgatgaa gtctttatca atcttccgag tgaaaaatac aatattggag agcttgtctc
     5881 tcagtttgaa acgatgggaa ttgatgtaac agttaatcta aatgcttttg gttgtagttt
     5941 ggcacgtaac aagcaaattc gtgagatggc aggattaaac gttgtgactt tttctacaac
     6001 attttataag actagtcatg taattgctaa gcggattatt gatatcatgg gtgcattggt
     6061 agggctgata ctatgtggtt tagtcagtat tgtactggtt cctttgattc gaaaggatgg
     6121 gggctctgct atttttgctc agacgcgtat aggaaaaaat ggtcgtcagt tcacttttta
     6181 taagtttcgc tctatgtgtg tagatgccga ggcgaaaaaa agagaactca tggaacaaaa
     6241 taccatgcag ggtggaatgt ttaaggtgga cgatgatcct cgtatcacga aaattggtcg
     6301 ttttatacgg aagactagct tggacgagct accacaggtt tataatgttc taaagggaga
     6361 tatgagtttg gttggcacac ggccaccaac agtggacgag tatgaacact ataccccaga
     6421 acaaaaacgt cgtctgagtt ttaaacctgg cataacaggc ttatggcagg tcagcggacg
     6481 aagtgaaatc aaaaatttcg atgaagttgt caaattagat gtagcctata tagacgattg
     6541 gacaatttgg aaagacattg aaattttatt gaagacagtt aaagtagtat ttatgagaga
     6601 tggagcgaag tagtttactt ttgttttaga ctactaggag aaaaatgaag aagtcagttt
     6661 atatcattgg ttcaaagggg attcctgcca agtatggagg atttgaaacc tttgttgaga
     6721 aattaacaga atatcaaaaa gatgggaaca tccaatacta tgttgcctgc atacgcgaaa
     6781 attctgcaaa atcaggattt acagcagata catttgagta caatggtgct atttgttaca
     6841 acattgatgt gcctaatatt ggtcctgcta gagccattgc ttacgatatt gcagcggtca
     6901 ataaggctat tgaattggct aagggaaaca aggacgaggc tcccattttt tacattctag
     6961 cttgtcgtat cggacctttt atttctggac ttaagaaaaa aattcgttcg atcggaggcc
     7021 gtttgctggt aaatccagat ggtcatgagt ggcttcgggc taaatggagc ctgccagttc
     7081 ggaagtattg gaaattttcg gaacagttga tggtcaaaca tgcagattta ttagtctgtg
     7141 atagcaaaaa tatcgaaaaa tatgtccgag aggactataa acagtatcag cccaagacga
     7201 cctatatcgc ttatggtaca gatactaccc cttcaagtct gaaatcagaa gatgccaaag
     7261 ttcgaaactg gtatcgtgaa aagggagtaa gcgaaaatgg ctattatcta gtggtgggac
     7321 gatttgttcc cgaaaacaac tatgagacca tgattcgtga atttatgaag tctaattcta
     7381 aaaaagactt tgttctcatt acaaatgtgg aacagaataa gttttacgat cagttgctca
     7441 aagatacagg cttcgacaaa gacccgagag tcaaatttgt tgggactgtc tatgaccaag
     7501 aattgctcaa atacatccga gagaatgctt ttgcctattt tcacggtcat gaagtgggag
     7561 ggaccaatcc atccttgctt gaagcattgg catccactag gcttaatcta ttactagatg
     7621 taggttttaa ccgtgaagtc ggagagaatg gtgccatcta ttggagaaaa gatgagctag
     7681 cgcgcgttat tgaagcagtg gagcaatttg atgagaacgc catttctgaa ctagataaaa
     7741 aatctagcca acgaattgca gaagctttta cgtgggaaga gatagtggtg gattatgagg
     7801 aagagtttga agggggaaaa agtgagtaac aagcaaattg cgattatgat ggcaacttat
     7861 aatggagcta aatacattgg agaacagata gactctattc ttaggcaaac ttatcaagat
     7921 tggaaattat ttatccatga cgattgttca aatgatgcta cttttcaaat ccttcagcaa
     7981 taccaagaaa aataccctaa aaaaattaag gttatcacag attcctctgt tatagggggg
     8041 agctcagaga aaaattttgc agctattcaa aaatgggtga cgaataatca tgatttttct
     8101 tattttatgt ttgcagatca agatgatttt tggtttccaa ataagattga gcgctcactt
     8161 tataaaatga aagaatcaga aaaggatgat ttacctattt tagttcatac tgatttagaa
     8221 gttgttgatg ataatttaaa tataattaac gattctttct tcgaatatcg tgccttagat
     8281 gtagatgtga cagaattgaa tcgtatactt atacaaaata acattacggg ttgtacaatg
     8341 ttatggaata gaagtttaaa caatctgtta gatttgaata gtaatgcagt agctatgcat
     8401 gattggtgga taagtttagt tgctgctagc tttgggaaaa ttgtttgcct taaagaacca
     8461 acaattaaat atcgtcaaca cggtgggaat gttgtggggg cgacacaagt caatacttta
     8521 ggttttatta tcaagaggtt gttaggaaat tctcatgtca aggaaacttt gaagctatca
     8581 tttgaacaag cagaatcatt tttaaaagtt tatcagaatt ctctaagtaa tgaggagaca
     8641 gatattattc gtgaatttat cagcattcca cataagcata aattggcgag aataagcact
     8701 gttataaaag gaggctatct aaagcaaagt gtggtgcaag taatcggtga gttaatgttt
     8761 atttagattt ttggagaaaa aatgaaaatt aattttatcc ttccatttaa gagaatgaca
     8821 ggtggaataa gagttatcta tacctatgca aattacctta ttgatcaagg acatgatgtg
     8881 gtttgttatg ttcctatgat tagttataga ggtagaaacc agacaatttt ttatcggata
     8941 aaagcttctt tggggaatac tctaaaaaac gataattggt ttgataagaa gtttgattta
     9001 aaacggatac cagtggtatc agaaaaatat atacgtgatg cagatgtagt aattgcgaca
     9061 gcttggcaaa cagcctatga tgtcgcaaat ttctcatcaa gcaaaggtca caaattttat
     9121 tttattcaag attatgaaat cttcaatgga ggaaaggaag aggtggaggc atcgtatcgc
     9181 ttgccactta cattaattac tgttacgagg agtttaaaaa aagctattca aaagtttaca
     9241 gataaaacta tttatgttgt atataatggt ctttctgaca acgagtatct tcatacagaa
     9301 aaaattagtc ataaggacct cactttgatg atgatgtatc atgaaagtga gcataagaaa
     9361 agtcaagagg ggttacaaat tatcgcaaaa ttaaagaagc gatatcctga tatgaagatt
     9421 aatatatttg gacgccgtat tccagaaaag ttacctgata cctataatgt gttgattaat
     9481 cctgaaagag aaaaaatttt aaagatgtat caggaatcgg atgtctatct ttttacaagt
     9541 gaaattgaag catggggact acctattgta gaagccatgg caaataaatg tgcagttgtt
     9601 ggtagaagtc gaggagcttt gttggaactc tcaaatggtc agaatactat agttgtagaa
     9661 gagttatcag aaatatataa taaggtagta catttacaag aggatcgatt attgttggca
     9721 caagttcaaa atgaagggta taaaactgtt ataccactaa attggagtaa ctcttgttta
     9781 gaatttgaga agattatatc aggggtatat attgaaaacg gtaaatagta taacaaatta
     9841 tattttatta ttagtatgga tagttataat gctctctcta tatacaggaa atggtgttac
     9901 tcctgttatt gttattttat tttttttgtc ggcattgtat tctttatatc gaaaaagcaa
     9961 attaagtata aatttaaatt ttttgtttat atatattttt ttagcctact atttgttatt
    10021 aacagttata ttcacacaag atttattggt gatgacttct aaatttatat tatttccaat
    10081 atttgtttat tatataatac ctaaaaatat aaatggcgtt ataagaatac tatctatttt
    10141 taaatctttc attggtttta ctgctatttt tggattatat gaatatatgc aacatttcaa
    10201 tcttatggtg aattttgtaa aaatagatgc agttaaatgg atacaaacga tgaatttgaa
    10261 tagtgtgtat tatcccagtt caatatttct ccactacacc tattttgcat atgttttgtt
    10321 actagctttt attttggtaa ttgttatccc atataagaac cgagtgttaa atttagttta
    10381 taaaacactt attgcaattt caattttttt gccccaatct cgtatagttt ggatagcttt
    10441 tggggtaatt ttaattcttt cgtttatact aaatagacag gggatattaa cctatagaaa
    10501 gttgagtgtt atagtactta ttttaattat agtagtctct ctctgcctat attttgatgt
    10561 gtttgcgttt atttctaatt atataagttt aagattttct tcactttatc gttatggact
    10621 ggctgatggt tctctaggtc aacgtattgg aactcttaga aattgggaaa attatttaga
    10681 ctctgatact ataaaggcta ttattgggtc aggatttggt ggtgtcaata gttacttgag
    10741 tacttattca ttttttaatg gctatactac agctgattca acagtgacaa gtttccttat
    10801 tgatactggg gttattggct tatttatctt tttattatct atgtttcaga tattagtaat
    10861 agtggtaaaa ggaaaaggaa tttttagaga attagcgtta tatactattg tagcttcttc
    10921 tatagttagt ttaacaattg atttttgggc aaattatgtt attcttcata tattttacgt
    10981 ggttattatc tgtgcattta taggaatgag attgactaag caagaaaaat aaaaatggat
    11041 ggggaaattc aaggttgtat gataatgtgc agaaggcata tggaatagtt gttttttaga
    11101 tttttaattt attttttaat acataatttt ctgtttttat ctaaaattaa ggaaggataa
    11161 tatgacaaaa agtatcttat attttttatc tacatctgat atatcatcgg gagctacccg
    11221 gtcattgtta cgattagttt cgatagttga ggattcagac tttagggtta ttatcatttt
    11281 accagaacat ggaaatgtgg aagatgagct tgtaaacaaa ggaattaaat actatgttgt
    11341 aaaacaatat atttggaatt attggataaa atatctcagt catactaaaa atatttttta
    11401 ctatttgaaa ttgccgttaa agtatttatt aaacagaata tcgtttcaca aaatcaacag
    11461 aattataaaa aaagaaaaag ttgatattat tcatatgaat acgttgactt cttttttagg
    11521 agctcaggca gcaatcaaac agagaaaaat attaatatgg catataaggg agtttatgga
    11581 agaggactta ggaattgaat tttgtaatag aaaaaaagca attgatttaa taaataaatc
    11641 aacatgtgta atttctatat ctgattcaat ttctaaaaat ttttccaacg aagttttggc
    11701 ttataaaaaa gtcattcata atggtttatc aattgatgac tattttatag ataaagtcgc
    11761 atttcagaac caaaagatta acattttatc ttcaggtaga attacgcctg gaaaagggca
    11821 ggttgattta gttagagcga tagctaatct tcctgagaga tataaacaga tgtttaaagt
    11881 tgatattata ggaatagttg aaagcgaaga atattttaaa gaaataaaag aagttatttc
    11941 aaattataaa cttgacggta ttgagtttca tggttttcaa tctgatccaa ctgatttttt
    12001 cagaaaatgt gatatcgtat gtgtgtgttc caaaaaagaa gctttcggtc gtattacagt
    12061 tgagggaatg ttgtctggag cgttagttat tgggacaaat tcaggtggta caaaagagat
    12121 aatttctaca ggagaaacag gatatctgta tgaaccagga gattatatgc agcttagtga
    12181 aattttaaaa actataataa acaataggag ttccatcttg gaaattgctt tgagaggaca
    12241 agagaaggct acattacgtt tttcagataa aaataatgcc atgcagatca tgcaactata
    12301 taaggaacta gaaaattgag tagaagatat aattacttac taaaaaatat tggattacta
    12361 actttaagca actttggttc taaaatttta gtctttttaa tggttccgtt atatacaagc
    12421 gtactatcta catctgatta tggaacatat gatttattta atacgacaat ctcattgcta
    12481 attccaatta tttcaattaa tatttctgaa ggggttcttc gatttgcatt agatgaaaaa
    12541 aatgacagta gtatagtata ttcaattggc tggaatatta taataaaagg tttcttagtt
    12601 gtagtattag gaattatttt caataatatc tttaatatat tcccattact taaagaaaat
    12661 tccataactt ttttattact ttatttatca actattgttt atcaatttct ttcttcattt
    12721 attagaggta tagataaagt ttctatatta tcaattgctg ctattctcaa tacaatttct
    12781 atattggggt ttaacattct atttcttata attatacctc taggtttggt tggatatttt
    12841 tggtctaata tattgggttt ggtgctacct agtttatact tgatatataa gatatctcaa
    12901 tataacatta agtacactag ccttcagaat aaaaagttac agcaaagact tgttagttac
    12961 agtattccct taatcttaaa ttcattaggt tggtggatta ataatgcaat agatagatac
    13021 gtagttattg cattttgtgg tgtagcggtg aatggcatct attcagttgg ttataaaatc
    13081 ccatcaattt taaatatttt tgcaaatata tttaaccaag cgtggatatt atcatctgta
    13141 aagtcttatc gtgatgaaga tagtgaatat ttcttttctc aagtttataa taagtataac
    13201 atgattatgg tattaatttc cgggctacta atttcttgta gtaaaatact tgctaagttt
    13261 ctatatatga atgaatttta tgatgcttgg aagtttgttc cgtttttact aattgcaaat
    13321 gtttttggag ctatttcagg atttgctggt ggaatttttt ccgcggttaa agattcaaaa
    13381 atatatagtc agtcaacctt agtaggagcg atagtgaata ttattttcac atttgttttt
    13441 gtatattatt atggagctat aggtgctgct attgccacta tgatatctta ctttgttgtt
    13501 tggataatac gtgttcatac aatgagaaaa tatataaagt taaaaatttt tattagaaga
    13561 gatgtatttt cctatgtatt gcttattttt cagtcaatag tcttatggtt ggaaaatagt
    13621 tatattcttt atcctataca agttgtgtta ttcttattat tagttatgtt attttataaa
    13681 gaaataaaga gtattattgg tgaattaaaa aagtttctaa cataagaacc aataagtacg
    13741 agtattgaaa ggagaaaaat gtgaaaatag cagtagcagg tacgggatat gttggtctat
    13801 ccattgcagt tttattgtct caacaacatc aagtaatggc ggtggacatt attcctgaga
    13861 aggtcgaatt aattaatcaa agaaagtcac ctattcaaga tgactatata gagaaatatc
    13921 tggcaaaaaa ggatttaaat ttagtggcta cattggatgc aaaagaagca tatcaagatg
    13981 cggattttgt tgtgattgca gctccaacta actatgatcc aaagaagaac ttttttgaca
    14041 cttctgctgt agagtctgtc attgaaacgg cgcttaaata taatccagat gccatcatgg
    14101 tcattaaaag tacagttcca gttggttata cagagtcagc tcgaaagaaa tttcagactg
    14161 aaaatatctt atttagtcct gaatttttgc gtgagtcaaa ggcgctttac gataacttat
    14221 atcccagccg tattatttta gggacagata aaaataatga acgcttggta agtgctgctg
    14281 agacatttgc gagattgctc caagaaggcg ctttaaaaga aaacattgat acattataca
    14341 tgggctttac tgaagctgag gcggtcaagc tttttgcaaa tacttacctt gctttgcgtg
    14401 tttcttattt taatgagctg gatacttatt ctgagatgaa ggggctagac actcaagcta
    14461 ttattgatgg agttggtttg gatccccgta ttggttcgca ctacaacaat ccttccttcg
    14521 gctatggtgg ctattgtctt cctaaagata ccaagcaact tcttgccaac tatgaagata
    14581 taccagaaga acttatagga gccatagtac ggagcaattc gacacgtaaa gactttattg
    14641 ctgatcaggt tcttaagatg gtagattatt atgattattc agcccataat attttcgatg
    14701 agagagtaga aaaagatatt attattggca tctatagatt gaccatgaag agtaatagcg
    14761 ataattttcg tcaaagctct attcaaggta ttatgaaacg tataaaagct aagggagtaa
    14821 gagtagttat ttatgaaccc actttagaaa gcgggagtac attttttgga agttccgtta
    14881 tcaatgattt agaggaattc aaacgactga gtaatgccat tgttgctaat cgctatgata
    14941 actcattaga agatgtcaag gaaaaagtct atacacgtga tatttttgaa agagattaat
    15001 ttagtataat aaaaatgaaa aaaataattg ttagaagcgg tccatactga gaagcaatgg
    15061 gaacgctcag cgacagaact tcctccattt atcattaaac gccttccagt tcgtttaacc
    15121 tttgataata actattttaa cgaccgttat caagtgattc ctattggtgg atacaatgtg
    15181 attattgaaa atatacttaa agacgtagaa gttgggctag gagtggattg ctttgactat
    15241 cgtgaagagc tggaagcatc tgctaacaaa gttgctttta caggaatgat tgaccagtat
    15301 tttgattata agcatggtga gctagagtat cgcagtttac gttttaagca cgaagtgctt
    15361 gatgaggaaa atcaccaagg aaatgctgta gtgaactata cagatcgtga gattccttat
    15421 actcgtatca ttgagcataa aaaatttgag tatggtctgc agcctaagac agtcataacg
    15481 catgaatatc cagctgactg gaaacgtgga gatgaaccat attatccaat taatgatgag
    15541 aaaaataatg ctatcttttc taaataccac gaagaagctt cacagaatga taaggttatc
    15601 ttctgtggac gtttagcaga ttataaatat tagtggtgat tgaacggata cttagtgtag
    15661 tagaggaaga atttagtaat taaaaaacaa cgaagaaagg ttatttcatt atgaaaggta
    15721 ttattcttgc gggtggctca ggtacccgtc tgtatccact tactcgagct acatcgaaac
    15781 agctgatgcc ggtttatgat aaacccatga tttactatcc tctgtcaact ttgatgttgg
    15841 cgggtattaa ggatattttg attatttcaa cgccacagga tttgccgcgc tttaaggact
    15901 tgctcttgga tggttccgaa tttgggatca gactttccta tgcggaacag cctagtccag
    15961 atggccttgc tcaggccttt cttatcggtg aggattttat tggtgacgat agcgttgctt
    16021 taatcttggg tgacaatatt tatcacggtc caggtttgag caagatgctc caaaaaactg
    16081 tttcgaaaga aaagggtgcg actgtttttg gttaccaagt gaaggatcca gaacgctttg
    16141 gtgttgtaga atttgatgaa aatatgaatg ctatttccat agaagaaaaa ccagagtgtc
    16201 ctcgctccaa ctatgcagtg acaggactgt atttctatga taacgatgtt gtcgaaattg
    16261 ccaagagtat caaaccaagt gctcgtggtg agttagaaat cacagatgtc aacaaggctt
    16321 acttggatcg tggtaattta tctgtcgaag tcatgggacg tggctttgct tggcttgata
    16381 caggaaccca tgaaagcttg ttggaagcct ctcaatatat tgaaacggtt caacgcatgc
    16441 aaaatgttca agttgccaat ttggaagaaa tcgcctatcg catgggttat attagtcgtg
    16501 aagatgtgct ggagttggcg caacctctta agaagaatga atacggacag tatctgctcc
    16561 gtttgattgg agaagtctag atgacagata attttttcgg aaaaatactt gcggtgcgta
    16621 aaattgatgc cattccaggt atgttagagt ttgatatccc agttcatggt gacaatcgtg
    16681 gctggtttaa ggaaaatttc cagaaggaaa agatggagcc acttggcttt cctgaaagct
    16741 tctttgctga agggaaacta caaaataacg tcagcttttc tcgcaaaaat gtccttcgag
    16801 gcctccacgc agagccttgg gataagtaca tctctgtagc agatggaggg aaagttctgg
    16861 gttcttgggt tgatctacgc gagggtgaaa cctttgggaa tacctatcag acaataattg
    16921 atgcaagcaa gggaatcttt gttcctcgag gcgtagctaa tggcttccaa gttttatcag
    16981 atacagtgtc atatagctat ctggtcaatg attattgggc tcttgaactc aaacccaagt
    17041 atgcctttgt gaactacgct gatccaagcc ttggtattga atgggaaaat attgcagaag
    17101 cagaggtttc agaagcagat aaacatcatc ccctacttaa ggatgtaaaa cctttgaaaa
    17161 aagaagattt gtaaaaagga aagaatatga ctgaatacaa aaatattatc gtgacaggtg
    17221 gagctggctt tatcggttct aactttgtcc attatgttta cgagaacttt ccagatgttc
    17281 acgtgacagt cctagataag ttgacttatg ctggaaaccg cgcgaatatt gaggaaattt
    17341 taggtaatcg tgttgagtta gttgttggtg acattgctga tgcggagttg gtagacaagt
    17401 tggctgctca agcagatgct atcgttcatt atgcagcgga aagccacaat gataattcgc
    17461 tcaatgatcc atcgccattt attcatacta acttcatcgg aacctatact cttttagaag
    17521 ctgctcgtaa gtatgatatt cgcttccacc atgtatcgac agatgaagtt tatggggatc
    17581 tccctttacg cgaagatttg ccaggtcatg gtgaaggacc aggtgagaaa tttactgctg
    17641 aaacaaaata caacccaagc tcgccttact catcaaccaa ggccgcatca gacttgattg
    17701 tcaaagcctg ggtgcgttct tttggagtca aggcaacgat ttccaactgt tcaaataact
    17761 acggtcctta tcaacatatc gaaaaattca tcccacgtca gattactaac atcctaagtg
    17821 gaattaagcc aaaactttac ggtgaaggta agaatgttcg tgactggatt cataccaatg
    17881 accattcttc aggagtttgg acaatcttga caaaagggca aatcggtgaa acctacttga
    17941 ttggggctga tggtgagaag aacaataagg aagttttgga gcttatcctt aaggaaatgg
    18001 gacaagctgc ggatgcctat gatcatgtga ctgaccgtgc aggacatgac cttcgctatg
    18061 cgattgatgc tagcaagctc cgtgatgagt tggggtggaa acctgaattt accaactttg
    18121 aagctgggct caaggcaaca atcaagtggt atacagataa ccaagaatgg tggaaagcag
    18181 aaaaagaagc tgttgaagcc aattatgcta agactcagga gattattaca gtataaaaag
    18241 caggaaatag ctgcttttta ttgctatatt gggaagagtt acatattaga aaggtctaga
    18301 gatgatttta attacagggg caaatggcca attaggaacg gaacttcgct atttattgga
    18361 tgaacgtaat gaagaatacg tggcagtaga tgtggctgag atggacatta ccgatgcaga
    18421 aatggttgag aaagtttttg aagaggtgaa accgacttta gtctaccact gtgcagccta
    18481 caccgctgtt gatgcagcag aggatgaagg aaaagagttg gacttcgcca tcaatgtgac
    18541 ggggacaaaa aatgtcgcaa aagcatctga aaagcatggt gcaactctag tttatatttc
    18601 tacggactat gtctttgacg gtaagaaacc agttggacaa gagtgggaag ttgatgaccg
    18661 accagatcca cagacagaat atggacgcac taagcgtatg ggggaagagt tagttgagaa
    18721 gcatgtgtct aatttctata ttatccgtac tgcctgggta tttggaaatt atggcaaaaa
    18781 cttcgttttt accatgcaaa atcttgcgaa aactcataag actttaacag ttgtaaatga
    18841 ccagtacggt cgtccgactt ggactcgtac cttggctgag ttcatgacct acctagctga
    18901 aaatcgtaag gaatttggtt attatcattt gtcaaatgat gcgacagaag acacaacatg
    18961 gtatgatttt gcagttgaaa ttttgaaaga tacagatgtc gaagtcaagc cagtagattc
    19021 cagtcaattt ccagccaaag ctaaacgtcc gctaaactca acgatgagcc tggccaaagc
    19081 caaagctact ggatttgtta ttccaacttg gcaagatgca ttgcaagaat tttacaaaca
    19141 agaagtgaga taagtagtag aatgattttc tagtctaata aaagaggcag ataatgaact
    19201 ccaaaggagc ttaagatgta cgattatctt gttgttggtg ctggtctctt tggcgcatag
    19261 ctttggctca gtttctatta tcgctcacac catccatcag aagtttaatc tgaaggtacc
    19321 caattatcgc caagaagaag attgggctag gatgggttta ccaatcacac gtaaggaaat
    19381 ctctaattgg catatcaagg caagtcaata ctatttagag tccctttata accttttacg
    19441 agaaaagttg ttagaacaac ctcttcttca tgcggatgaa acctcttatc gggttctaga
    19501 gagtgatagc catctgacct actattggac ctttttgtct gggaaatcag agaaacaagg
    19561 gattacgctt taccatcatg atcagcgtcg gagtggttcg gtagtgcaag aattcctagg
    19621 aaattattct gcctatgcga tagcagtcca aagtttagga gcaaggcgac gctaagcttg
    19681 gtaaactacg aaccgctaga agcttatcgt caactggaag aagctgaact tgttggatgt
    19741 tgggcgcatg tgagaaggaa gttttttgaa gcgcccccca agcaagcgga taaatcatcg
    19801 ttaggagcta aaggtttagc ttattgtgat cagttatttg ccttggaaag agactgggag
    19861 gctttgctag ctgatgaacg actacagaaa cgtcaagaag agctccaacc cctaatggaa
    19921 gatttctttg cttggtgccg gcgtcagtca gttttatcgg gttcaaaact aggaagggca
    19981 attgaataca gcctcaagta taaagaaacc tttaagacca ttttaaaaga cggacatctg
    20041 gtcctttcca ataatctagc tgaacgcgcc attaaatcat tggttatggg acggagtaaa
    20101 agagtccagt ggactctttt agcctaagct cagtttaaaa aagtgagggt ggttattttc
    20161 tcaaagtttt gaaggagcta aagcaagagc tattattatg agcttattgg aaacagctaa
    20221 acgtcatcaa ctaaatagcg agaaatatct atcctatctt ctagaatgtc ttccaaacga
    20281 ggaaactctc gtaaacaaag aggttttaga ggcctattta ccatggacta aagttgtaca
    20341 agaaaagtgc aaataagaaa tctccagatt aggaactatc cgtgagttct ctagtctgga
    20401 gatttttcaa tatacttcgt tattgggcgc ttacaatgat attcatattt tttgcaaaga
    20461 tgttgtttga aaaataattt tcaaaaattc tgaaaattct gttgacaact ttctgaaaag
    20521 agtctataat ggagagaaag ttttaaagga gaaaatgatg aaaagttcaa aactacttgc
    20581 ccttgcgggc gtgacattat tg
//
