LOCUS       CR931680               25559 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 546/62 (serotype 21).
ACCESSION   CR931680
VERSION     CR931680.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 25559)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 25559)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..25559
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="546/62"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC21_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC21_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI33732.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            293..463
                     /gene="aliB"
                     /locus_tag="SPC21_0002"
                     /pseudo
     CDS             293..463
                     /gene="aliB"
                     /locus_tag="SPC21_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(462..995,997..1323))
                     /gene="tnp"
                     /locus_tag="SPC21_0003"
                     /pseudo
     CDS             complement(join(462..995,997..1323))
                     /gene="tnp"
                     /locus_tag="SPC21_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(join(933..995,997..1305))
                     /gene="tnp"
                     /locus_tag="SPC21_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 1.2e-23"
                     /pseudo
     gene            1547..3001
                     /gene="wzg"
                     /locus_tag="SPC21_0004"
     CDS             1547..3001
                     /gene="wzg"
                     /locus_tag="SPC21_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI33735.1"
                     /db_xref="GOA:Q4K0S0"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K0S0"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILASSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDL
                     PSYAMPDSNLYVLEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1547..1672
                     /gene="wzg"
                     /locus_tag="SPC21_0004"
                     /note="Signal peptide predicted for SPC1079 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 42 and 43"
     misc_feature    1760..2107
                     /gene="wzg"
                     /locus_tag="SPC21_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.5e-63"
     misc_feature    2285..2728
                     /gene="wzg"
                     /locus_tag="SPC21_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 8.4e-70"
     gene            3003..3734
                     /gene="wzh"
                     /locus_tag="SPC21_0005"
     CDS             3003..3734
                     /gene="wzh"
                     /locus_tag="SPC21_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI33736.1"
                     /db_xref="GOA:Q4K0R9"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R9"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLIIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDKGCYT
                     QVNSSHILKSKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    3006..3614
                     /gene="wzh"
                     /locus_tag="SPC21_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 4.3e-37"
     gene            3740..4435
                     /gene="wzd"
                     /locus_tag="SPC21_0006"
     CDS             3740..4435
                     /gene="wzd"
                     /locus_tag="SPC21_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI33737.1"
                     /db_xref="GOA:Q4K0R8"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R8"
                     /translation="MMKEQNTIEIDVFQLLKTLWKRRLMILLVALVTGAGAFAYSTFV
                     VKPEYTSTTRIYVVNRNQEDKPGLTNQDLQAGTYLVKDYREIILSHDVLEKVATNLKL
                     DMPARALASKVQVTVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFSFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLRI
                     PLLGLVPDLDKMK"
     misc_feature    3740..3856
                     /gene="wzd"
                     /locus_tag="SPC21_0006"
                     /note="Signal peptide predicted for SPC1081 by SignalP 2.0
                     HMM (Signal peptide probability 0.725) with cleavage site
                     probability 0.447 between residues 39 and 40"
     misc_feature    3761..4177
                     /gene="wzd"
                     /locus_tag="SPC21_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 9.7e-55"
     gene            4445..5134
                     /gene="wze"
                     /locus_tag="SPC21_0007"
     CDS             4445..5134
                     /gene="wze"
                     /locus_tag="SPC21_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI33738.1"
                     /db_xref="GOA:Q4K0R7"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R7"
                     /translation="MPTLEISQAKLDFVKKAEEYYNALCTNLQLSGDNLKVFSITSVK
                     LGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMSGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            5150..6517
                     /gene="wchA"
                     /locus_tag="SPC21_0008"
     CDS             5150..6517
                     /gene="wchA"
                     /locus_tag="SPC21_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33739.1"
                     /db_xref="GOA:Q4K0R6"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R6"
                     /translation="MNGKIVKSSLVIIQSFLVILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQAFFKRGYLIELVQTLKYILFFALAIGISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESNEVVGEL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDATVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIVGALVGLIL
                     CGLVSVVLVPLIRKDGGSAIFAQTRIGKNGRYFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    5150..5242
                     /gene="wchA"
                     /locus_tag="SPC21_0008"
                     /note="Signal peptide predicted for SPC1083 by SignalP 2.0
                     HMM (Signal peptide probability 0.894) with cleavage site
                     probability 0.356 between residues 31 and 32"
     misc_feature    5933..6514
                     /gene="wchA"
                     /locus_tag="SPC21_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 6.1e-159"
     gene            6504..7721
                     /gene="wchF"
                     /locus_tag="SPC21_0009"
     CDS             6504..7721
                     /gene="wchF"
                     /locus_tag="SPC21_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33740.1"
                     /db_xref="GOA:Q4K0R5"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R5"
                     /translation="MERNSLLLFQTTRRKMKKSVYIIGSKGIPAKYGGFETFVEKLTE
                     YQKDGNIQYYVTCMRENSAKSGFTADTFEYNGAICYNIDVPNIGPARAIAYDIAAVNK
                     AIELAKENKDEAPIFYILACRIGPFISGLKKKIRSIGGRLLVNPDGHEWLRAKWSLPV
                     RKYWKFSEQLMVKHADLLVCDSKNIEKYIREDYKQYQPKTTYIAYGTDTTPSSLKSED
                     AKVRNWYREKGVSENGYYLVVGRFVPENNYETMIREFIKSKSNKDFVLITNVEQNKFY
                     DQLLKETGFDKDLRVKFVGTVYDQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTK
                     LNLLLDVGFNREVGEDGAIYWKKDELAHVIEEVERFDEGDISELDEKSSQRIADAFTW
                     EKIVSDYEEVFKG"
     misc_feature    7167..7658
                     /gene="wchF"
                     /locus_tag="SPC21_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.0022"
     gene            7725..8882
                     /gene="wcwA"
                     /locus_tag="SPC21_0010"
     CDS             7725..8882
                     /gene="wcwA"
                     /locus_tag="SPC21_0010"
                     /note="member of homology group 63"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33741.1"
                     /db_xref="GOA:Q4K0R4"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R4"
                     /translation="MKRILYLHAGAEMYGADKVLLELIKGLDSKEFETHVILPNDGVL
                     VEALRQVGAQVSVLDYPILRRKYFNPKGIFEYLKSYHRYSQKIAQYVRENGIVLVHNN
                     TTAVLEGIYLKRKVKLPLIWHVHEIIVKPKAISDFINFLMGRYANKIVTVSQAVASHV
                     NQSPFIKEGQVQVIYNGVDNAVYHPMPASTVREQFSIPEEALVIGMVGRVNAWKGQGD
                     FLEAVTPILEQNPNAIAFLAGSAFAGEEWRVEELESKIAKSSVVSQIKRIDYYEHTTE
                     LYNMFDIFVLPSTNPDPLPTVVLEAMACGKPVVGYRHGGVCEMVDEGTNGLLATPNQP
                     AELSKVIQELVENPEKRNQFGQASVERQRELFSLDSYIKNFSELYKTDRKD"
     misc_feature    8286..8807
                     /gene="wcwA"
                     /locus_tag="SPC21_0010"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 3.7e-31"
     gene            8885..9883
                     /gene="wcwK"
                     /locus_tag="SPC21_0011"
     CDS             8885..9883
                     /gene="wcwK"
                     /locus_tag="SPC21_0011"
                     /note="member of homology group 64"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33742.1"
                     /db_xref="GOA:Q4K0R3"
                     /db_xref="UniProtKB/Swiss-Prot:Q4K0R3"
                     /translation="MNKIDFVVTWVDGNDPVWKEKKSRYDGSVSTSKQSMNSVKAYRE
                     WGTFKYWFRGVERFAPWVNKVYLVTDQQRPSWLDINSEKLVLVDHTEIICNDCLPVFS
                     ANPIESNIHRIPGLSEHFVFFNDDMYLTAPVEPTDFFSEDGLPKYNTALSPIIPERYG
                     TGNFQINDMEIVTSYFSRNEILKNGQFFDPKQGLKSIVKSLLYRNSQFICGFWESHLP
                     YPLLKSTMDLIWEKEKAVLGRTSASRFRNPSDTNVWLFKYWQIASGQYAVGNPKLGRL
                     FSLDNAGPDFWNLLNSGKYKIMCINDVYDIKDEEKVMQEFIAAMKNLLPDKSTFEL"
     gene            9899..10876
                     /gene="wcyT"
                     /locus_tag="SPC21_0012"
     CDS             9899..10876
                     /gene="wcyT"
                     /locus_tag="SPC21_0012"
                     /note="member of homology group 194"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33743.1"
                     /db_xref="GOA:Q4K0R2"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R2"
                     /translation="MPSVCALVVTYNRSKYLQKALEGILNQQQEISGILIYNNNATDN
                     TEEILMKFGYVDSKGDKIKENYLYSTEKDGKHFYYYHNDENLGGAGGFANGIRLISEL
                     DYDYVWIMDDDVYPEPNCLSEIMKQMSVQNVQVGIPNRTDENFDDRAIIGFDFDDYHK
                     FWTEMRKTVTYGPFDEEAIKVVDMPFEGPVVEMALLRKVGIPDSGFFIEYDDSDFAQR
                     LQQYSDIIFATKAQLHRQLAVKVDPSEVKKVEPYNWRNYYKIRNNIIFDKRYGKNWKV
                     RQLSPLILIAHHIVIAIRHQHLKHNLPIIWKGFWDGVFQRMGKRVDPNY"
     misc_feature    9911..10498
                     /gene="wcyT"
                     /locus_tag="SPC21_0012"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 9.5e-22"
     gene            10889..11917
                     /gene="wcyU"
                     /locus_tag="SPC21_0013"
     CDS             10889..11917
                     /gene="wcyU"
                     /locus_tag="SPC21_0013"
                     /note="member of homology group 195"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI33744.1"
                     /db_xref="GOA:Q4K0R1"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R1"
                     /translation="MSDLLLSFIMPTYNSAEYLADTMDSLVASIGDYNHLVEIICVDD
                     GSWDNTVTILEGYKSIYDNLIIIRNEHGGVSQARNTALDIVSGKYISFVDSDDLYEKD
                     FLNTFISLDKNFDFLFTDVGGLKDEISFQEINEKEKLKIFKNNFNLGEYTIHPGIAGK
                     FFRTSLINDIQLRFNTQLSFAEDILFNFTLLTASRHVILSPVNFYHVNGTHSLMYYNE
                     KNLKGQIVFVDRIRQILKGYSESSEIVLIENFIILKAMTVYIDRYFGPLWLNGTYSLN
                     EASKLMKSTIEDNDFSKAFNSNRLDYSIGNRYVVFRKLLRFRQYKLCLLYNRIMDKIK
                     GYERFRKQ"
     misc_feature    10907..11401
                     /gene="wcyU"
                     /locus_tag="SPC21_0013"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 1.5e-29"
     gene            11914..13134
                     /gene="wzy"
                     /locus_tag="SPC21_0014"
     CDS             11914..13134
                     /gene="wzy"
                     /locus_tag="SPC21_0014"
                     /note="member of homology group 240"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI33745.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0R0"
                     /translation="MIKLSIHDIYRYFLYLIFFMNLLFFNIVSDLTYTIQNFSVYLTF
                     LLMGMYLLQRRISKLTIFTSITVLLFFLLIMFNLYRQGLPVNGFLSFNSKIYLLRNFS
                     FILLVFPISEILKPKYSLNFLKVVFVFGILAILFRTFIWMSYNYAGLNIAPGIIEERG
                     VNWTRYGAVRLQALFLDGYVLAYLLCKLLISDSKNKVSYSLLLLITLFYEGVIYASRS
                     QLIGFSIMFIAIYLLKNKNLLNKLLSFLSLSLASFAILLSPYYEKFIDSFSVSNSDYG
                     AGTMVRIVGRRYYQEIWNQNKLLGFGPISDGNIFAGWKYYLSDLGIIRMLYQFGIIGF
                     IICLLPILYGCLVGFKNRLHFKGMLLFCLSLFVLVTSFASQNLYDYNRIMLLPLLLGL
                     ANAVSSTQADKDMV"
     gene            13131..14555
                     /gene="wzx"
                     /locus_tag="SPC21_0015"
     CDS             13131..14555
                     /gene="wzx"
                     /locus_tag="SPC21_0015"
                     /note="member of homology group 7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI33746.1"
                     /db_xref="GOA:Q4K0Q9"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q9"
                     /translation="MKVLKNYAYNLSYQLLLIILPVITTPYITRVFSSDDLGTYGYFN
                     SIVTYFILLATLGVANYGTKEISGHRKEIRRNFWGIYTLQLGATILSGTLYAILCLSL
                     PSMQDSVAYILGFSLLSKGLDISWLFQGLEDFRKIIVRNITVKLVGVISIFLFVKSAK
                     DLYLYVFLLTIFELLGQLSMWVPAREFIGKPHIDINHAKKHLKPVILLFLPQIAISLY
                     VTLDRTMLGALASKTDVGIYDQALKLVNILLTLVTSLGSVMLPRVSSLLSQSDYKSVK
                     KMYQMSFLIYNSVIFPIIAGMLIVNDDFVQFFLGRDFQDARYAIAIMMFRMFFIGWTN
                     IMGIQILIPHNKNKEFMISTTVPAIVSVGLNLIFLPNLGFIGAAIVSVLTEALVWGIQ
                     LHFTWSYLKEVPIIGSMIKIVIASGIMYAFLVSMKSVVHVSPAINVALYALLGGVIYV
                     ALILLFKVVNLKELKQELLKNREI"
     misc_feature    13137..13931
                     /gene="wzx"
                     /locus_tag="SPC21_0015"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 1.9e-68"
     gene            14557..15657
                     /gene="glf"
                     /locus_tag="SPC21_0016"
     CDS             14557..15657
                     /gene="glf"
                     /locus_tag="SPC21_0016"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI33747.1"
                     /db_xref="GOA:Q4K0Q8"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q8"
                     /translation="MYDYLIVGAGLSGAIFAHEATKRGKKVKVIDKRDHIGGNIYCEN
                     VEGINVHKYGAHIFHTSNKKVWDYVNQFAEFNNYINSPVANYKGSLYNLPFNMNTFYA
                     MWGTKTPQEVKDKIAEQTADTKDVEPKNLEEQAIKLIGPDIYEKLIKGYTEKQWGRSA
                     TELPPFIIKRLPVRLTFDNNYFNDRYQGIPIGGYNVIIENMLKDVEVELGVDFFAHRE
                     ELEVSAEKVVFTGMIDQYFDYKHGELEYRSLRFEHEILDEENYQGNAVVNYTEREIPY
                     TRIIEHKHFEYGTQPKTVITREYPADWKRGDEPYYPINDEKNNAMFAKYQEEASKNDK
                     VIFCGRLADYKYYDMHVVIERALSVVEEEFSN"
     misc_feature    14992..15594
                     /gene="glf"
                     /locus_tag="SPC21_0016"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 1.2e-138"
     gene            15685..16554
                     /gene="rmlA"
                     /locus_tag="SPC21_0017"
     CDS             15685..16554
                     /gene="rmlA"
                     /locus_tag="SPC21_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI33748.1"
                     /db_xref="GOA:Q4K0Q7"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q7"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIKDILIISTPQDLPRFKDLLLDGSEFGIKLSYAEQPSPDGLAQAFIIGEKFIGDDSV
                     ALILGDNIYHGPGLSKMLQKAAQKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEK
                     PKDPRSNYAVTGLYFYDNDVVEIAKGIKPSARGELEITDINKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKN
                     EYGRYLLRLIGEV"
     misc_feature    15688..16404
                     /gene="rmlA"
                     /locus_tag="SPC21_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 2.7e-118"
     gene            16555..17151
                     /gene="rmlC"
                     /locus_tag="SPC21_0018"
     CDS             16555..17151
                     /gene="rmlC"
                     /locus_tag="SPC21_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI33749.1"
                     /db_xref="GOA:Q4K0Q6"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q6"
                     /translation="MTDNFFGKTLAVRKIDAISGMLEFDIPVHGDNRGWFKENFQKEK
                     MVPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADNGKVLGTWVDLREG
                     ETFGNIYQTEIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYS
                     DPELGIEWENLEEAEVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    16588..17121
                     /gene="rmlC"
                     /locus_tag="SPC21_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 4.4e-16"
     gene            17161..18210
                     /gene="rmlB"
                     /locus_tag="SPC21_0019"
     CDS             17161..18210
                     /gene="rmlB"
                     /locus_tag="SPC21_0019"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI33750.1"
                     /db_xref="GOA:Q4K0Q5"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q5"
                     /translation="MTKYKNIIVTGGAGFIGSNFVHYVYNNFPDVYVTVLDKLTYAGN
                     RANIEEILGDRVELVVGDIADAALVDKLAAEADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDLRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQTAD
                     AYDHVTDRAGHDLRYAIDASKLCDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    17176..18132
                     /gene="rmlB"
                     /locus_tag="SPC21_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00028"
     misc_feature    17179..17919
                     /gene="rmlB"
                     /locus_tag="SPC21_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 3.1e-76"
     misc_feature    17182..17994
                     /gene="rmlB"
                     /locus_tag="SPC21_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 4.1e-05"
     gene            18276..19127
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
     CDS             18276..19127
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI33751.1"
                     /db_xref="GOA:Q4K0Q4"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q4"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATKDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    18276..19124
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.3e-147"
     misc_feature    18279..18908
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 5.6e-19"
     misc_feature    18279..18920
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0001"
     misc_feature    18282..19010
                     /gene="rmlD"
                     /locus_tag="SPC21_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 2.4e-08"
     gene            19477..20139
                     /gene="glf"
                     /locus_tag="SPC21_0021"
     CDS             19477..20139
                     /gene="glf"
                     /locus_tag="SPC21_0021"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI33752.1"
                     /db_xref="GOA:Q4K0Q3"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q3"
                     /translation="MNTFNKLWGVVTPAGAQAKIEEQRAILNGKTPENLEEQEISLVG
                     TDIYEKLIKDYTEKQWGKPTTELPSFIIRRLPVHLTYDNNYFNDTYQGIPIGDYNVII
                     ENMLKDVEVELGVNFFANRQELEASAEKVVFTGMIDQYFDYKHGELEYRSLRFDHEVL
                     DEENYQGNAVVNYTEREIPYTRIIEHKHFEYGTQEKTVITREYPADFFLHNRKHYKRN
                     SK"
     misc_feature    19624..20136
                     /gene="glf"
                     /locus_tag="SPC21_0021"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 2.7e-76"
     gene            20136..21209
                     /gene="wcyO"
                     /locus_tag="SPC21_0022"
     CDS             20136..21209
                     /gene="wcyO"
                     /locus_tag="SPC21_0022"
                     /note="member of homology group 80"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase"
                     /protein_id="CAI33753.1"
                     /db_xref="GOA:Q4K0Q2"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q2"
                     /translation="MTRISMKKIKEYEILKVIAIILVVVGHSTYYNIYTGYGGIDYQQ
                     YINNHLSLAVYKLLSKLTEIIYYFHMPLFMAISGAFFSIQVKNNRWHGIGSLLTNKFR
                     RLMIPFLVFTLVYTIPIKYISNYFDGISFWKAVSGQLFLFGNSHLWYLYALFIVFIVG
                     FYILKKRTLFYVYLLLYILHILSYSVHLTLVSAPLQYLFWFSMGFLFEFKREQYNHYL
                     KNNKWLSFLLVLLFIACVALKFVLKDNHEVLNRIIMDLAAVLGSLICYNISYYLSDKR
                     ELTENRLFNVILINGLGIYIFSDTLNYLILNISYSISNRFMFTSFGILALFLIRIFFT
                     LFIGLGLTLLFKKIFKKHSWLVN"
     misc_feature    20160..21167
                     /gene="wcyO"
                     /locus_tag="SPC21_0022"
                     /note="HMMPfam hit to PF01757, Acyltransferase family,
                     score 1.2e-05"
     gene            complement(order(21403..21984,22038..22706))
                     /gene="tnp"
                     /locus_tag="SPC21_0023"
                     /pseudo
     CDS             complement(join(21403..21984,22038..22706))
                     /gene="tnp"
                     /locus_tag="SPC21_0023"
                     /note="member of homology group 13"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1167 transposase"
     misc_feature    complement(join(21904..21984,22038..22250))
                     /gene="tnp"
                     /locus_tag="SPC21_0023"
                     /note="HMMPfam hit to PF01610, Transposase, score 1.8e-40"
                     /pseudo
     gene            complement(22824..23333)
                     /gene="tnp"
                     /locus_tag="SPC21_0024"
                     /pseudo
     CDS             complement(22824..23333)
                     /gene="tnp"
                     /locus_tag="SPC21_0024"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase (fragment)"
     misc_feature    complement(22830..23333)
                     /gene="tnp"
                     /locus_tag="SPC21_0024"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 4.7e-06"
                     /pseudo
     gene            complement(23500..23691)
                     /gene="tnp"
                     /locus_tag="SPC21_0025"
                     /pseudo
     CDS             complement(23500..23691)
                     /gene="tnp"
                     /locus_tag="SPC21_0025"
                     /note="Lone member of homology group 0242"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative ISPSy5-like transposase (fragment)"
     gene            complement(23864..24461)
                     /gene="tnp"
                     /locus_tag="SPC21_0026"
                     /pseudo
     CDS             complement(join(23864..24211,24195..24461))
                     /gene="tnp"
                     /locus_tag="SPC21_0026"
                     /note="member of homology group 31"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1671 transposase"
     misc_feature    complement(23870..24193)
                     /gene="tnp"
                     /locus_tag="SPC21_0026"
                     /note="HMMPfam hit to PF05717, IS66 Orf2 like protein,
                     score 3.7e-53"
                     /pseudo
     gene            order(24528..24833,24862..25251)
                     /gene="tnp"
                     /locus_tag="SPC21_0027"
     CDS             join(24528..24833,24862..25251)
                     /gene="tnp"
                     /locus_tag="SPC21_0027"
                     /note="member of homology group 19; member of homology
                     group 19"
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1381 transposase"
                     /protein_id="CAI33758.1"
                     /db_xref="GOA:Q4K0Q1"
                     /db_xref="InterPro:IPR002559"
                     /db_xref="UniProtKB/TrEMBL:Q4K0Q1"
                     /translation="MLAVLKTAYQLKHAKGGRKPKLSLEDLLMATLQYVREYRTYEEI
                     AADFGIHESNLLRRSQWVEVTLVQSGVTISRTPLSSEDTVMIDATEVKINRPKKRISE
                     MKAQAIVTSQGRIVSLDIAVNYCHDMKLFKMSRRNIGQAGKILADSGYQGLMKIYSQA
                     QTPRKSSKLKPLTVEDKTYNHALSKERSKVENIFAKVKTFKMISTTYRNHRKRFGLRM
                     NLIAGIINHELGF"
     misc_feature    24642..24707
                     /gene="tnp"
                     /locus_tag="SPC21_0027"
                     /note="Predicted helix-turn-helix motif with score
                     1106.000, SD 2.95 at aa 39-60, sequence
                     RTYEEIAADFGIHESNLLRRSQ"
     misc_feature    join(24774..24833,24862..25242)
                     /gene="tnp"
                     /locus_tag="SPC21_0027"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 4.2e-14"
     gene            25512..>25559
                     /gene="aliA"
                     /locus_tag="SPC21_0028"
     CDS             25512..>25559
                     /gene="aliA"
                     /locus_tag="SPC21_0028"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33759.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ89"
                     /translation="MMKSSKLLALAGVTLL"
BASE COUNT     7997 a   4182 c   5289 g   8091 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaggactgt ataaaagaca gaaatccttt gttttttata accaaggttt ataaactttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaaga aaatgaacat
      301 aaagaagcgt gtccttagtg caggcctgac ttttgcatct gctttgcttt tagctgcttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttggtggaa atccaactac
      421 atttaactat ctattagact attacgctga taacatagtc aattgaaaca agaacaggac
      481 aaaagagcct cgtaaaaggt attgcaactg ggtaatacct ttttgaggtg ctttttgata
      541 tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt
      601 ttacgcccaa actcctcgca taaaagttct aacttaccca ttctatggaa tcttacatta
      661 tccataataa taaccgatgg tgtgtttaat gttggtaaga gaaaattctg aaaccaagct
      721 tcaaaaaagt cgctcgtcat cgtctcttcg taagtcattg gagcgattaa ttcaccattt
      781 gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt
      841 aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttcg
      901 tcaatctaaa caggtactag gtgctttaaa ctattaaaat tcttaagaaa taaggctact
      961 ttttctgggt cttgttcata gtaggtgtgg ttcttttttt cgagtgtagc ccatagcttt
     1021 gagcgcatag tggatggtag ttggatgaca gccaaattca gaagctattt cagtcaaata
     1081 agcgtctgga ttgtcagtaa gatagttttt aagtctatct ctatcaactt ttcttggttt
     1141 tgttcctttt acttggtggc ttagctctcc tgttttctct tttagcttta accagccata
     1201 aatagtatta cgtgagattt ggaaaacgtg tgatgcttct gttatactac ctgttcgctc
     1261 acaataagag agaacttttt tacgaaaatc tattgaatat gccataaaaa gattatgcca
     1321 cattgtgtac tatagtagat tgaaactaga atagtacacc tctgcttcta aaacattgtt
     1381 agaaatcgat ttgactgtcc tgatcgattt gtcctgttct tatttcattt tactatattt
     1441 ttgtttcgcg ggaagtctac taagatattt aaagatgcag atagtaaaaa aagatgtaga
     1501 cattaccgta aaaaagtgat ataatcgtat gatgttcaat gtataggtgt taatcatgag
     1561 tagacgtttt aaaaaatcac gttcacagaa agtgaagcga agtgttaata tcgttttgct
     1621 gactatttat ttattgttag tttgtttttt attgttctta atctttaagt acaatatcct
     1681 tgcttttaga tatcttaatc tagtggtaac tgcgttagtc ctactagttg ccttggtagg
     1741 gctactcttg attatctata aaaaagctga aaagtttact atttttctgt tggtgttctc
     1801 tatccttgcc agctctgtgt cgctctttgc agtacagcag tttgttggac tgaccaatcg
     1861 tttaaatgcg acttcgaatt actcagaata ttcaatcagt gtcgctgttt tagcagatag
     1921 tgagatcgaa aatgttacgc aactgacgag tgtgacagca ccgactggga ctgataacga
     1981 aaatattcaa aaactactag ctgatatcaa gtcaagtcag aataccgatt tgacggtcaa
     2041 ccagagttcg tcttacttgg cagcttacaa gagtttgatt gcaggggaga ctaaggccat
     2101 tgtcctaaat agtgtctttg aaaatatcat cgagtcagag tatccagact acgcatcgaa
     2161 gataaagaag atttatacca agggattcac taaaaaagta gaagctccta agacgtctaa
     2221 gaatcagtct ttcaatatct atgttagtgg aattgacacc tatggtccta ttagttcggt
     2281 gtcgcgatca gatgtcaata tcctgatgac tgtcaatcga gataccaaga aaatcctctt
     2341 gaccacaacg ccacgtgatg cctatgtacc aatcgcagat ggtggaaata atcaaaaaga
     2401 taaattaact catgcgggca tttatggagt tgattcgtcc attcataccc tagagaacct
     2461 ttatggtgta gatattaatt attatgttcg tttgaatttt acctcatttt tgaaattgat
     2521 tgacttattg ggaggggtag atgttcataa tgatcaagag ttttcagctc tacatgggaa
     2581 gttccatttc ccagtaggga atgtccatct agactctgag caggctctag gttttgtacg
     2641 tgaacgctac tcactagccg atggagaccg tgaccgtggt cgcaaccaac aaaaggtgat
     2701 tgtggctatc cttcaaaaat taacgtcaac cgaagcactg aaaaattata gtacgatcat
     2761 taatagcttg caagattcta tccaaacaaa tatgccactt gagactatga taaatttggt
     2821 caatgctcag ttagaaagtg gagggaatta taaagtaaat tctcaagatt taaaaggtac
     2881 aggtcggacg gatcttcctt cttatgcaat gccagacagt aacctctatg tgctggaaat
     2941 agatgatagt agtttagctg tagttaaagc agctatacag gatgtgatgg agggtagatg
     3001 aaatgataga catccattcg catatcgttt ttgatgtaga tgacggtccc aaatcaagag
     3061 aggaaagcaa ggctctcttg gcagaatcct acagacaggg ggtgcgaacc attgtctcta
     3121 cctctcaccg tcgtaagggc atgtttgaaa ctccggaaga gaagatagca gaaaactttc
     3181 ttcaggttcg ggaaatagct aaggaagtgg cgagtgactt gatcattgct tacggggctg
     3241 aaatttacta cacaccagat gttctggata agctggaaaa aaagcggatt ccgaccctca
     3301 atgatagtcg ttatgccttg atagagttta gtatgaacac tccttatcgc gatattcata
     3361 gcgctttgag caagatcttg atgttgggaa ttactccagt cattgcccac attgagcgct
     3421 atgatgctct tgaaaataat gaaaaacgcg ttcgagaact gatcgataag ggctgttaca
     3481 cgcaagtaaa tagttcacat atcctcaaat ctaaactttt tggcgaacgt tataaattca
     3541 tgaaaaaaag agctcagtat tttttagagc aggatttggt ccatgtcatt gcaagtgata
     3601 tgcacaatct agatggtaga cctcctcata tggcagaagc atatgacctt gttacccaaa
     3661 aatacggaga agcgaaggct caggaacttt ttatagacaa tcctcgaaaa attgtaatgg
     3721 atcaactaat ttaggagaaa tgatgaaaga acaaaacacg atagaaatcg atgtatttca
     3781 attattaaaa accttgtgga aacgcaggct aatgatttta ttagtggcac ttgtgacagg
     3841 tgcgggggct tttgcatata gcacttttgt tgttaagcca gaatatacga gtaccacgcg
     3901 aatttacgta gtgaatcgca atcaagaaga caagccgggg ctgacaaatc aggatttgca
     3961 ggcaggaact tacctggtaa aagactaccg tgagattatc ctttcgcatg atgtattgga
     4021 aaaagtagcg acaaatttga agttggatat gccagcaaga gcgttagcca gcaaagttca
     4081 agtgactgta ccagctgaca ctcgtatcgt ctcaatctct gtcaaggata aacagccaga
     4141 ggaagccagt cgcatcgcta attctctacg agaagttgct gcagaaaaga tcgtcgctgt
     4201 aacgcgagta tctgatgtaa cgacacttga agaagcgcga ccagctacga ctccctcttc
     4261 tccaaatgtt cgacgcaatt ccttgtttag ttttcttgga ggagcagtcg taacagtaat
     4321 tgctgttctt ttgattgagt tgctcgacac tcgtgtgaaa cgtcctgaag atgtcgaaga
     4381 tgtactgcga attccacttt tagggctcgt tccagatttg gacaaaatga aataggagga
     4441 agttatgcca acgttagaaa tctcacaggc aaaattggat tttgtaaaaa aggcagagga
     4501 atattataat gctttgtgca cgaacctaca gttaagtgga gataatttaa aagtattttc
     4561 tatcacttct gtgaaactag gagaaggaaa atcaacgact tccaccaata tcgcttgggc
     4621 ttttgcgcgt gcaggttaca aaacgctgct gattgatgga gatattcgca attctgttat
     4681 gtcaggtgtc tttaaagcaa gggataagat tacaggcctg acagaatttt tatcaggaac
     4741 tacagaccta tcacaagggc tttgtgatac caatatcgaa aatctctttg taattcaggc
     4801 tggttctgtg tcaccgaatc cgacagctct tcttcaaagt aagaatttca gtacaatgct
     4861 tgaaaccttg cgtaaatatt ttgactacat cattgtagat actgctcctg tcggtgtcgt
     4921 gattgatgca gctattatta cgcgaaaatg cgatgcttct attttagtga cggaggcagg
     4981 tgaaataaat cgacgggata ttcaaaaagc aaaagaacag ttggaacaca cagggaagcc
     5041 gtttttggga gttgtgttga ataaattcga tacttcagta gacaaatatg gttcttatgg
     5101 aaattatgga gattacggga aaaataaaaa ataggtcggg gggatagaga tgaatggaaa
     5161 aatagtaaag tcttcattgg tcataatcca gagttttctt gttattttat tgacttatct
     5221 acttagtgct gtgagagaag cggagattgt ttcaacaaca gctattgcac tttatatcct
     5281 ccattatttt gtcttttata tcagtgatta tggacaggct ttctttaaaa ggggatattt
     5341 gattgaactt gtccagacat tgaaatatat cctattcttt gcactagcga ttggtatttc
     5401 taattttttc ttagaggatc gatttagtat ttccagacga ggcatgattt acttcctcac
     5461 attacatgct ctcttagtct atgtgctaaa cctatttatc aagtggtatt ggaagcgggc
     5521 ttatcccaac tttaaaggaa gtaagaagat tctcctactt acagcaactt ctcgtgtcga
     5581 aaaggtactg gatagattaa tagaatcaaa tgaggttgtt ggggagttgg tagccgtcag
     5641 tgtcttagat aaaccagatt ttcagcatga ttgtttaaag gtagtagcag agggggagat
     5701 agtaaacttt gcgactcatg aggtggtcga tgaagtcttt atcaatcttc caagtgaaaa
     5761 atacaatatt ggagagcttg tctctcagtt tgaaacgatg ggaattgatg caacagttaa
     5821 tctaaatgcc tttgatcgta gtttggcacg taacaagcaa attcgtgaga tggcaggatt
     5881 aaacgttgtg actttttcta caacatttta taagactagt catgtaattg ctaagcggat
     5941 tattgatatc gtgggtgcat tggtagggct gatactatgt ggtctagtca gtgttgtact
     6001 ggttcctttg attcgaaagg atgggggctc tgctattttt gctcagacgc gtattggaaa
     6061 aaatggtcgc tacttcactt tttacaagtt ccgctccatg tgtgtagatg ccgaggcgaa
     6121 aaaaagagaa ctcatggaac aaaataccat gcagggtgga atgtttaagg tggacgatga
     6181 tccgcgtatc acgaaaattg gtcgttttat aaggaagact agcttggacg agttgccaca
     6241 gttttataat gttttaaagg gagatatgag tttggttggc acacggccac caacagtgga
     6301 cgaatatgag cactataccc cagaacaaaa acgtcgtcta agttttaaac ctggtataac
     6361 aggcttatgg caggtcagtg gacgaagtga aatcaaaaat ttcgatgaag ttgtcaaatt
     6421 agatgtggct tatatagatg attggacaat ttggaaagac attgaaattt tattgaagac
     6481 agttaaagta gtatttatga gagatggagc gaaatagttt acttttgttt cagactacta
     6541 ggagaaaaat gaagaagtca gtttatatca taggttcaaa gggaattcct gccaagtatg
     6601 gaggatttga aacctttgtt gagaaattaa cagaatatca aaaagatggt aacatccaat
     6661 actatgttac ctgcatgcgc gaaaattcgg caaagtcagg atttacagca gatacatttg
     6721 agtacaacgg tgctatttgt tacaacattg atgtgcctaa tattggtcct gctagagcca
     6781 ttgcctacga cattgcagcg gtcaataagg ctattgaatt ggctaaagaa aacaaggacg
     6841 aggctcccat tttttacatt ttagcttgtc gtatcgggcc ttttatttct ggacttaaga
     6901 aaaaaattcg ttcgatcgga ggccgtttgc tggtaaatcc agatggtcat gagtggcttc
     6961 gagctaaatg gagcttgcca gttcggaagt attggaaatt ttcggaacag ttgatggtta
     7021 aacatgcaga tttattagtc tgcgatagca aaaatatcga aaaatatatt cgagaggact
     7081 ataaacagta tcagcccaag acgacctata tcgcttatgg tacagatact accccttcaa
     7141 gtctgaaatc agaagatgcc aaagttcgaa actggtatcg tgaaaaggga gtaagcgaaa
     7201 atggctatta tctagtggtg ggacgattcg ttcccgaaaa caactatgaa accatgattc
     7261 gtgaatttat caagtctaag tccaataagg actttgtcct tattacaaat gtggaacaga
     7321 ataaatttta cgatcagttg ctcaaggaaa caggtttcga caaggatcta agagtcaaat
     7381 ttgtgggaac agtctatgac caagaattgc tcaagtatat ccgtgaaaat gctttcgcct
     7441 atttccatgg acatgaagtt gggggtacca atccatcgct tcttgaagct ttagcatcca
     7501 ctaaactcaa cttgttgttg gatgtcggct ttaaccgtga agttggtgaa gacggagcca
     7561 tttattggaa aaaagatgag ctagcgcatg taatcgaaga agtggaacga tttgatgaag
     7621 gtgatatttc ggaattagac gaaaagtcta gccaacgaat tgcggatgca tttacgtggg
     7681 aaaagattgt gtcagattat gaagaagtgt ttaaaggata aggaatgaaa cggattttat
     7741 acttgcatgc tggtgcagaa atgtatggag cagataaggt tttattggag ttgatcaaag
     7801 gattggattc caaagaattt gagacgcacg ttatcttgcc aaatgacggt gttttagtcg
     7861 aggctttgcg ccaggttgga gctcaggtca gcgtgttgga ttatccgatt ttacgtagaa
     7921 aatactttaa tcctaagggg atttttgaat atctgaaatc ctatcatcgc tactctcaaa
     7981 aaatcgctca atatgtgcgt gagaatggga tagttcttgt tcataacaat acaacagccg
     8041 ttctggaagg gatttatcta aagagaaaag taaaacttcc cttgatctgg catgttcatg
     8101 agattattgt taagcctaag gccatttcag attttatcaa cttcttgatg ggacgttatg
     8161 caaataaaat cgtaacagta tctcaagcag tggccagtca tgtcaatcag tctcccttca
     8221 tcaaagaagg gcaggtccag gttatctata atggagtgga caatgcggtc tatcatccga
     8281 tgccagcaag cacagtgcgt gaacaatttt ctatcccgga agaggctctt gtcattggta
     8341 tggttggtcg cgtcaacgct tggaaggggc aaggagattt tctagaagcg gtgacgccga
     8401 ttttggagca gaatcccaat gccatcgctt ttctggctgg aagtgccttt gctggtgaag
     8461 agtggcgagt tgaagaactc gagtctaaga ttgccaaatc aagtgtagtc tcacaaatca
     8521 aacgaattga ctattatgag catacgactg agctttataa tatgtttgat atctttgttt
     8581 taccaagtac caatcctgat cccctaccaa cagtggtact agaggcgatg gcatgcggca
     8641 aaccagtagt cggctatcgt catggtggtg tttgcgaaat ggttgatgaa gggacaaatg
     8701 gcttactggc cactccaaat cagcctgctg aactatcgaa agtcattcaa gaattggtgg
     8761 agaatccaga gaaaagaaac caatttggcc aagcatcagt agaaagacaa agagagttgt
     8821 tttctttaga tagttacatt aagaacttct cggagttgta taaaacagat agaaaagatt
     8881 agttatgaat aaaatagatt ttgttgttac ttgggttgat gggaatgacc ctgtatggaa
     8941 agaaaaaaaa tcaaggtatg atggctcggt cagtacttct aaacagagta tgaactcggt
     9001 caaagcttac cgagaatggg gaacctttaa atactggttt agaggagttg aaagatttgc
     9061 cccttgggtc aataaggtct acctcgtgac cgaccagcaa agaccaagct ggttagatat
     9121 aaacagtgaa aaattggtct tggtagatca tacagagatt atctgtaatg actgcctacc
     9181 agttttttct gccaatccga tcgaaagtaa tatccatcga attcctggtc tctctgagca
     9241 ctttgtcttt tttaatgacg atatgtattt gacggctcca gttgaaccga cagatttttt
     9301 ctcagaggat ggtttaccca aatataatac ggctctttct ccgattattc ctgaaagata
     9361 tggaacagga aattttcaga taaatgacat ggaaattgtc actagctatt tcagtcgaaa
     9421 tgaaattttg aagaatgggc aattctttga tccaaagcag ggattaaaaa gtattgttaa
     9481 gtcgctacta tacagaaata gtcagtttat ctgtggtttc tgggagagtc atctgcccta
     9541 tcctctacta aaatcaacga tggatttgat atgggaaaag gaaaaagctg tcttggggag
     9601 aacctcagcg agtcgcttta gaaatccgtc tgataccaat gtttggctct ttaagtattg
     9661 gcagattgct agtggtcaat acgctgtcgg aaatcctaag ttggggagac tcttttcttt
     9721 ggataatgcc ggaccagatt tttggaactt actaaattct ggcaaataca aaattatgtg
     9781 tatcaatgat gtgtatgata ttaaggatga agaaaaagta atgcaagaat ttattgctgc
     9841 aatgaaaaat cttttgcctg ataaaagtac atttgaatta taaaaaagga gtgggaatat
     9901 gccatcagtt tgtgctttag ttgtgacata taatcgttca aaatatctgc aaaaggcttt
     9961 ggaaggtatt ttgaatcaac aacaagaaat ttcgggaatt ttaatttata acaataatgc
    10021 tacagataat actgaagaaa ttcttatgaa attcggttat gttgattcaa aaggcgataa
    10081 gataaaagaa aattatcttt attcgaccga aaaagatgga aaacacttct actattacca
    10141 taatgacgaa aacctaggag gagctggagg ctttgcaaat ggaattcgat taatttcaga
    10201 gcttgattat gattatgttt ggattatgga cgatgatgtc tatccggaac ctaattgttt
    10261 atccgaaatt atgaaacaaa tgagtgtcca aaatgtacag gtaggtatcc cgaatcgtac
    10321 agatgaaaat tttgatgacc gtgccattat cggttttgat tttgatgact atcataaatt
    10381 ttggacggaa atgagaaaaa cagtaacata cggtcccttt gatgaagaag cgataaaagt
    10441 ggttgatatg ccatttgaag gaccagttgt tgaaatggca ttgcttcgta aagttggtat
    10501 tcctgatagt ggctttttta ttgagtacga tgattcggac tttgcacaac gcctacaaca
    10561 gtattcagat ataatttttg caacaaaagc acaattgcat cgtcaacttg ctgtaaaagt
    10621 ggatccaagc gaggtaaaaa aagtggaacc ttataattgg agaaattact ataaaattcg
    10681 aaataatatt attttcgata agcgatatgg aaaaaattgg aaagtacgtc aattgagtcc
    10741 tttaattcta attgctcacc atattgtgat tgctattcgc catcagcatt taaaacataa
    10801 cttgccaatt atttggaagg gtttttggga tggagttttt caacgaatgg ggaaacgagt
    10861 agaccccaat tattaaaagg agaaaaaaat gtctgattta ctgttgagtt tcattatgcc
    10921 gacctataac tctgcagaat acttagcaga tacaatggat agtttagtag cctctatagg
    10981 tgattataat catttagtgg aaattatttg tgttgacgat ggctcatggg ataatacagt
    11041 tactatttta gaaggataca agtctattta tgataatttg attattataa gaaatgagca
    11101 tggtggggtt agtcaggcta gaaatacagc tttagatata gtttctggga aatatatcag
    11161 ttttgttgat agtgatgatt tgtatgagaa agatttttta aatactttta tttcattgga
    11221 caagaatttt gatttccttt tcactgatgt gggtggactt aaggatgaaa ttagtttcca
    11281 agaaattaat gaaaaggaaa aattaaaaat ttttaaaaat aattttaatt taggtgagta
    11341 tacaattcat cctggaatag ctgggaaatt ttttagaaca agtttaatta atgatattca
    11401 attgagattt aacacgcaac tgtcatttgc tgaggatatt ttatttaatt ttacattgct
    11461 gacagcctca agacatgtga ttctatcccc tgtaaatttt tatcatgtca atgggactca
    11521 tagtttaatg tactacaatg aaaaaaattt aaaagggcag attgtatttg tagatagaat
    11581 acgtcaaatt ttaaaaggat actctgaatc atcggaaata gtcttaatag agaattttat
    11641 tatcttgaag gctatgactg tttatattga tcgttatttt ggaccattgt ggttgaatgg
    11701 aacttattca ttgaatgaag catcaaaatt aatgaaatct acaattgagg ataatgactt
    11761 ttcaaaagct tttaatagta atcgcttaga ttattctatt ggaaatcgtt atgttgtttt
    11821 cagaaaattg ttgaggttta gacagtacaa actatgtttg ttatacaatc gtataatgga
    11881 taaaattaag ggatatgaga ggtttaggaa acaatgatta aactttcaat tcacgatata
    11941 tatcgttatt ttctctacct catttttttt atgaacttat tattctttaa tattgtttca
    12001 gacctaacct atacaatcca aaatttttcg gtttatttga catttttatt gatgggaatg
    12061 tatttactac aaagacgaat atcaaagtta acaattttca cgtcaattac agttctatta
    12121 tttttcttat tgataatgtt caatttatat agacaaggac tacctgttaa tggctttttg
    12181 tcttttaata gtaaaatata tttgttgaga aatttcagtt ttattctact agtctttcca
    12241 atatcagaga tattaaagcc aaagtatagt ttaaattttt taaaagtagt ttttgtattt
    12301 ggaattcttg caattttatt tcgtactttt atttggatga gttataatta tgctggttta
    12361 aatatcgctc cgggtataat tgaagaaaga ggtgtgaatt ggacacgtta tggagcggtt
    12421 cgtctacaag cccttttttt ggatggctac gttttggcat atttgttatg taagttatta
    12481 ataagtgatt caaagaataa agtatcttat agtctacttt tgttgattac tttgttctat
    12541 gagggagtga tttatgcttc taggtcacaa cttattggtt tcagtataat gtttattgca
    12601 atttatttat taaaaaataa gaacttacta aataaattac tcagtttttt atcactcagt
    12661 ttagcttctt ttgcaattct actgagtcca tattatgaaa aatttattga tagtttctct
    12721 gtatcaaata gcgattatgg tgcaggtacg atggttcgta ttgttggaag gagatactat
    12781 caagaaatat ggaatcaaaa taaactttta ggttttgggc caatctcaga tggcaatatt
    12841 tttgctggtt ggaagtatta tttatctgat ttaggtatta ttagaatgct ctatcaattc
    12901 ggaattatag gttttatcat ttgtttatta cctattttgt atggatgttt agttggtttc
    12961 aagaatagat tacactttaa aggtatgctg ttattttgtc tttctctatt tgtattagta
    13021 actagctttg cttcgcaaaa tttatatgat tataatagaa ttatgcttct tccgttgtta
    13081 ttagggttag caaatgctgt ttcatcaact caagcagata aggatatggt atgaaagttc
    13141 ttaaaaatta cgcctataat ctctcttatc aactgttgct gattattttg ccggttatta
    13201 ctactcctta cattactcgg gtgtttagct cggatgactt gggtacctat ggttatttca
    13261 actcaatcgt cacctatttt atcttattgg caactttagg agtagctaat tatggtacca
    13321 aggaaatttc agggcatcga aaagaaattc gaaggaattt ctgggggatt tataccctac
    13381 agctaggagc gactatttta tccggtaccc tctatgctat actatgtctg agtttgccat
    13441 ctatgcaaga ttcagttgcc tatatcttag ggtttagttt gctttcaaag ggattagata
    13501 tttcttggtt atttcaaggt ttggaagact tccggaagat tattgtgcga aatattacag
    13561 tcaaacttgt cggtgtaatc tcaatcttct tgtttgtaaa atctgctaaa gacctttatc
    13621 tctatgtttt tttactaacc atatttgaac tgttaggcca gttgagtatg tgggtgcctg
    13681 ctcgagaatt tattggaaag ccacatatag atattaacca cgcaaagaag catctaaagc
    13741 ctgtcattct tctctttctt cctcaaatcg ccatttcctt gtatgtgacc ttggatagaa
    13801 ctatgcttgg agctttagct tcaaaaacag atgtagggat ttatgatcag gctttaaagc
    13861 tagtaaacat cttgttgact ctagtaacct cactagggag tgttatgttg ccacgagtgt
    13921 ctagtcttct atcacaaagt gattataagt ctgtgaagaa aatgtaccaa atgtcctttt
    13981 taatttataa ttcagtcatt tttccaatta ttgctgggat gttgatcgtg aatgacgact
    14041 ttgttcaatt ctttttagga agggatttcc aagatgcccg ctatgcaatt gcaattatga
    14101 tgtttagaat gttctttatt ggatggacca atatcatggg aattcaaatc ctcatccccc
    14161 ataataaaaa taaagaattt atgatttcga ccactgttcc cgctattgtc agtgtcggat
    14221 tgaacctcat cttcttaccg aatctaggtt ttatcggggc agcgattgtg tctgtgttga
    14281 cagaagcttt ggtatggggg attcaacttc acttcacatg gtcttatctt aaagaggtac
    14341 caattattgg ctcaatgatc aagattgtta ttgcttcggg gatcatgtat gctttcttgg
    14401 tatctatgaa gtccgttgtt catgtttcac ctgctattaa tgttgctctg tatgctttgc
    14461 taggtggagt gatttatgta gccttgattt tgcttttcaa ggtggtgaat ttgaaagagt
    14521 tgaaacagga actattaaaa aatagggaga tttaatatgt acgactattt aatcgttgga
    14581 gctggtttgt ctggagctat ttttgctcac gaagctacaa aacgtggaaa aaaagtaaaa
    14641 gtgattgata aacgcgatca cattggaggg aacatatact gtgagaatgt agaaggtatc
    14701 aatgttcata aatatggtgc ccatatcttc catacttcta ataaaaaagt ttgggactat
    14761 gtcaatcaat tcgctgaatt taacaactat atcaattcac ctgtcgcgaa ctacaaagga
    14821 agtctttata atcttccttt caatatgaat actttctatg ctatgtgggg gacaaaaact
    14881 ccacaggaag tgaaagataa gattgctgag cagacggctg atacgaagga tgttgagcca
    14941 aaaaatctgg aagaacaagc tatcaagttg attggtccgg atatctatga aaagttgatc
    15001 aagggctata ctgaaaagca atggggacgc tcagcaacgg aacttcctcc atttatcatt
    15061 aaacgtcttc cagttcgtct aacatttgat aataactatt ttaacgaccg ttaccaagga
    15121 attcctattg gtggttataa tgtaattatc gaaaacatgc ttaaagacgt tgaagttgag
    15181 cttggtgttg atttctttgc tcaccgtgaa gagttagaag tatcagctga aaaagttgtc
    15241 ttcacaggaa tgatcgacca gtattttgac tacaaacacg gggagttaga ataccgtagc
    15301 cttcgctttg agcatgaaat tttggacgag gaaaattatc aagggaatgc tgtagtgaac
    15361 tatacagagc gtgagatccc ttatactcgt atcatcgaac acaaacattt tgaatatgga
    15421 acgcagccaa agacagttat cacgcgtgaa tatccggctg actggaagcg tggagacgag
    15481 ccctactatc cgatcaacga tgagaaaaat aatgctatgt ttgctaagta ccaagaggaa
    15541 gcttcaaaga atgataaagt tatcttctgt ggacggttag cagattataa atattatgat
    15601 atgcatgtag ttattgagcg agcgcttagc gtagtagaag aagaatttag taattgaaaa
    15661 acaacggaga aaggttattc cattatgaaa ggtattattc ttgcaggcgg ctcaggtacc
    15721 cgactgtacc cccttacacg agctgcatca aaacaactga tgccggttta tgataaacct
    15781 atgatttatt atcctttgtc gacattaatg ttggctggaa ttaaagatat tttgattatc
    15841 tcaactcctc aagatctacc tcgttttaag gatttacttt tagatggttc cgagtttggt
    15901 atcaagcttt cttatgccga gcagcctagt ccagatggac tagcgcaagc ctttatcatc
    15961 ggtgaaaaat ttatcggtga cgatagtgtt gctttaattt taggcgataa tatctatcat
    16021 ggacctggtt tgagcaaaat gcttcaaaag gcagcccaga aagagaaagg tgcgactgtt
    16081 tttggctacc aagtgaagga tccagagcgt tttggtgtag tcgagtttga tacagacatg
    16141 aatgccattt ccatagaaga aaaaccgaag gatcctcgct ctaactatgc tgtgactggt
    16201 ctgtatttct atgataatga tgttgtagaa attgctaaag gcattaaacc aagtgcacgt
    16261 ggcgaattag aaattacaga tatcaacaag gcttacttgg atcgtggtga tttgtctgtt
    16321 gaactcatgg gacgtggttt tgcttggttg gatactggca ctcatgaaag tttactagaa
    16381 gcttctcagt atatcgaaac agttcaacgg atgcagaatg ttcaagttgc aaacttggaa
    16441 gaaattgcct atcgtatggg ctatatcagt cgtgaagatg tactagagtt ggcacaacct
    16501 ctgaagaaga atgaatacgg acgatatttg ctccgtttga ttggagaagt ctagatgaca
    16561 gataattttt ttggaaaaac acttgcagtt cgtaaaattg atgccatttc aggtatgtta
    16621 gagtttgata ttcccgttca tggagacaat cgtggttggt ttaaggaaaa tttccagaag
    16681 gaaaagatgg tgccacttgg ctttcctgaa agcttctttg ctgaagggaa actgcaaaat
    16741 aacgtcagct tttctcgcaa aaatgttctt cgaggcctcc atgctgagcc ttgggacaag
    16801 tacatctctg ttgcagataa tgggaaggtt ctaggaacat gggttgattt gcgtgagggt
    16861 gaaacttttg ggaatattta ccagacagag attgacgcta gtaagggaat ctttgtccct
    16921 cgtggcgtag ccaatggatt tcaagtccta tctgatacag tttcttatag ttatctggtt
    16981 aatgactatt gggcgcttga actcaaacct aagtatgcat ttgttaacta ctctgaccca
    17041 gaattaggaa ttgagtggga aaatctggaa gaagcagagg tatctgaagc agacaaacat
    17101 catcccctac ttaaggacgt gaaacctttg aaaaaagaag atttggaata aggaaataat
    17161 atgactaaat ataaaaacat catcgtgaca ggtggggctg gttttatcgg ttctaacttt
    17221 gtccactatg tttacaataa ctttccagat gtgtatgtga cagtgctgga caagctgact
    17281 tatgcaggta atcgtgccaa tattgaagaa attttaggcg accgtgttga gttagtcgtt
    17341 ggagatattg ctgatgcagc cttggtagat aagttagcag ctgaagcgga tgccattgta
    17401 cactatgcgg cagaaagcca caatgacaat tcgcttaatg acccctcgcc atttatccat
    17461 accaacttca tcggaactta tacactcttg gaagcggctc gtaaatacga ccttcgtttc
    17521 caccatgtgt cgactgacga agtctatggg gatctgccgc tgcgtgaaga tttaccaggt
    17581 catggggaag gaccaggtga gaaatttacg gctgaaacca agtacaatcc aagctcgcct
    17641 tactcatcga ctaaggcggc ttcagacttg attgtcaaag cttgggtacg ctcatttggc
    17701 gtcaaagcga ctatttccaa ctgttccaac aactatggtc cttaccagca tattgagaag
    17761 tttattccac gacaaatcac caatatcttg agcggtatca agccaaaact ctatggtgaa
    17821 ggtaaaaacg ttcgtgactg gatccatacc aatgaccatt cttcaggagt ttggacaatc
    17881 ttgacaaaag ggcaaatcgg tgaaacctac ttgattgggg ctgatggtga gaagaacaat
    17941 aaggaagttt tggaacttat ccttaaggaa atgggacaaa ctgcggatgc ctatgatcat
    18001 gtgactgatc gtgcaggaca tgaccttcgc tatgcgattg atgcaagcaa gctctgtgat
    18061 gagttggggt ggaaacctga atttaccaac tttgaagctg ggctcaaggc aacaatcaag
    18121 tggtatacag ataaccaaga atggtggaaa gcagaaaaag aagctgttga agccaattat
    18181 gctaagactc aggagattat tacagtataa aaagcaggaa atagctactt tttattgcta
    18241 tattgggaag agttacatat tagaaaggcc tagagatgat tttaattaca ggggcaaatg
    18301 gccaattagg aacggaactt cgctatttat tggatgaacg taatgaagaa tacgtggcag
    18361 tagatgtggc tgagatggac attaccgatg cagaaatggt tgagaaagtt tttgaagagg
    18421 tgaaaccgac tttagtctac cactgtgcag cctacaccgc tgttgatgca gcagaggatg
    18481 aaggaaaaga gttggacttc gccatcaatg tgacggggac aaaaaatgtc gcaaaagcat
    18541 ctgaaaagca tggtgcaact ctagtttata tttctacgga ctatgtcttt gacggtaaga
    18601 aaccagttgg acaagagtgg gaagttgatg accgaccaga tccacagaca gaatatggcc
    18661 gtactaagcg tatgggggaa gagttagttg agaagcatgt gtctaatttc tatattatcc
    18721 gtactgcctg ggtatttgga aattatggca aaaacttcgt ttttaccatg caaaatcttg
    18781 cgaaaactca taagacttta acagttgtaa atgaccagta cggtcgtccg acttggactc
    18841 gtaccttggc tgaattcatg acctacctag ctgaaaaccg caaggaattt ggttattatc
    18901 atttgtcaaa tgatgcgaca aaagacacaa catggtatga ttttgcagtt gaaattttga
    18961 aagatacaga tgtcgaagtc aagccagtag attccagtca atttccagcc aaagctaaac
    19021 gtccgctaaa ctcaacgatg agcctggcca aagccaaagc tactggattt gttattccaa
    19081 cttggcaaga tgcattgcaa gaattttaca aacaagaagt gagataagta gtagaatgat
    19141 tttctagtct aataaaagag gcagataatg aactccaaag gagcttaaga tgtacgatta
    19201 tcttgttgtt ggtgctggtc tctttggtgc agtctttgcc catgaagcag ccttaaaagg
    19261 aaaaaagtaa aagttattga aaaacgaaat catatcgcgg gtaatatcta tactcgtgaa
    19321 gaggaaggaa ttcaagttta tcaatatggt gctcatatct tccatacttc tgataaggag
    19381 atctgtgatt atgtaaatca gcttgcagag tttaaccgtt acacaaattc tcctgttgca
    19441 aactataagg gtgagattta taaccttcct tttaatatga atactttcaa taaactctgg
    19501 ggagttgtaa cgccagcagg agcacaagct aagattgagg aacaacgtgc tattttaaat
    19561 ggtaaaactc ctgaaaattt ggaagaacag gagatttctc ttgtaggtac agatatctac
    19621 gaaaaattaa tcaaagacta tacagagaaa cagtggggca aaccaactac tgaacttcca
    19681 tcctttatta ttcgccgttt accagtacac ctgacctatg ataacaacta ttttaacgat
    19741 acctatcaag ggattccaat tggtgattat aatgttatca tcgaaaatat gctgaaggat
    19801 gtagaagtag aacttggagt gaactttttt gccaatcgtc aagaattaga ggcttctgct
    19861 gaaaaggttg tctttacagg aatgattgac caatactttg attataaaca tggtgagtta
    19921 gaataccgta gtcttcgttt tgatcatgaa gttctagatg aggaaaacta tcaaggaaac
    19981 gcagttgtaa actatacaga acgagaaatt ccttatactc gtattattga gcataaacac
    20041 tttgagtatg gtactcagga gaaaacggtt attactcgtg aatacccagc tgatttcttt
    20101 ttgcataata gaaaacatta taagaggaac tctaaatgac aaggattagt atgaaaaaaa
    20161 taaaagaata cgaaatttta aaagtaatag ccattatctt agttgtggta ggacacagca
    20221 cctactataa tatttatact ggttatggtg ggatagatta tcaacaatac ataaacaacc
    20281 atttatcctt agctgtatat aagctgttaa gtaaattgac agagattatt tattattttc
    20341 atatgccttt attcatggct atatctggtg cgtttttctc tattcaggtt aaaaataatc
    20401 gatggcatgg cattggctca ttattaacaa ataagtttag aagactaatg ataccatttt
    20461 tagtctttac tctagtatat acaataccaa taaaatacat atcaaattac tttgatggta
    20521 tctctttctg gaaagcggtc tctggacaat tatttctatt tggaaattct cacttgtggt
    20581 atttgtatgc attgtttatt gtctttatag ttggctttta tattctgaaa aaacgtacgt
    20641 tattttatgt ttatctactg ctatatattc tacacatctt gagttactca gttcatttaa
    20701 cattagtaag tgcaccatta caatatctct tttggttttc tatgggcttc ttatttgaat
    20761 ttaagaggga gcagtataat cattatttaa agaataataa gtggctaagc tttttattgg
    20821 tgctactatt tatagcatgt gtagccctaa aatttgtgct taaagataac catgaagttt
    20881 tgaataggat aattatggat ctagcagctg tgctaggctc acttatttgt tataatatat
    20941 cgtattatct cagtgataaa agagaattaa cagagaatag actatttaat gttattttga
    21001 ttaacggatt aggaatttac atcttttctg atactttaaa ttatttaata ttaaatatct
    21061 catattctat cagtaatcga ttcatgttta catcatttgg tattttagca ttatttttga
    21121 ttagaatttt ctttacttta tttatagggt taggtttaac actgttattt aaaaaaatat
    21181 tcaaaaaaca ttcttggtta gtaaactaac caactttagt taatttatta ttgtcttgag
    21241 gaaatattca aagagaagtt tttgaaattt ttctattact ctagaaatag atactggaag
    21301 attgtggtca tgtatttctt atctattttg taaccgccca ataacgaagt atattgaaaa
    21361 atctcggctc tttgtcaact gtagtgggtt gaaaaaaagc taagctcgag aaaggacaaa
    21421 ttttgtcctt tcttttttga tattcagagc gataaaaatc cgttttttga agttttcaaa
    21481 gtttcgaaaa ccaaaggcat tgcgtttgat aagtttgatg agattattgg tcgcttccaa
    21541 tttggcgtta gaatagtgta gttgaagggc gttgacgatt ttctctttgt cctttagaaa
    21601 ggctttaaag acagtctgaa aaagaggatg aacctgcttt agattgtcct caatgagtcc
    21661 gaaaaatttc tccggtttct tattctgaaa gtgaaacagc aagagttgat agagctgata
    21721 gtggtgtttc aagtcttctg aatagcttaa aatcttgtct aaaatctctt tattggttaa
    21781 gtgcatacga aaagtaggac gataaaatcg cttatcactc agtttacggc tatcctgttg
    21841 tatgagcttc cagtagcgct tgatagcctt gtattcatgg gattttcgat gaaactgatt
    21901 catgatttga acacgcacac gactcatagc acggctaaga tgttgtacaa tatgaaagcg
    21961 ttcaagaacg attttagcat tcgggagtga aacagtctgg gagactgttt cagcctgagt
    22021 ctagaaattt gaaagcgaag ctgtttagcc aagtcatagt aaggactaaa catatccata
    22081 gtaatgattt tgacgcgaca tcggacaact ctatcatatt taagaaagtg atctcggatg
    22141 acagcttgtg ttctaccctc aagaacagtg atgatattga gattgttaaa atcttgcgca
    22201 atgaagctca tctttccctt tgtaaaagca tactcatccc aagatataat ctcaggaaga
    22261 caagaaaaat catgtttaaa gtgaaaatca ttgagcttac gaataacagt tgaagttgag
    22321 atggaaagct gatgggcaat atcggtcata gaaatctttt caatcaactt ttgagcagtc
    22381 ttttggttga tgatacgagg gatttggtga tttttcttga cgagggaagt ctcagcgacc
    22441 gctatttttg aacagtgata gcacttaaag cgacgctttc taaggagaat tctagtaggc
    22501 ataccagtcg tttcaagata aggaatttta gaaggttttt gaaagtcata tttcttcaat
    22561 tggtttccgc actcagggca agatggggcg tcgtagtcca gtttggcgat gatttctttg
    22621 tgtgaatccc tattgacgac atctataatt tggatatttg tgtctttgat atcgagtagt
    22681 tttgtgataa aatgtaattg ttccatatga atctttctaa tgagttgttt ggtcgctttt
    22741 cattatagat cttatgggac tttttttcta caataaaata ggctccataa tatctatagt
    22801 ggatttaccc actacaaata ttatagagcc gaataatctc ctaggaattc ttgtactact
    22861 gaaccacttc gacactgatc atggtggtaa agcgtaatcc cttgtttctc tgatttacct
    22921 gacaaaaaag tccaatagta agtcagctga ctatcacttt ctaagacccg ataagaggtt
    22981 tcatctgcat gaagaagagc ttgttctaac aacttttctc ataaaaggtt ataaagagac
    23041 tctaaatagt attgactcgt cttgatatgc caattagaaa tttccttacg tgtgattggt
    23101 aaacccatct tagcccaatc ttcttcttag cgataattgg gtaccttcag attaaacttc
    23161 tgatggatgg tgtgagcgat aatagaggct gaaccaaggc tatgcgccaa aggggcttta
    23221 gggacaggag cttttacaat tttatcactt ggatttttat cactgcatgc ttggcatttg
    23281 taagcgtgtt ggatatgatc cactcttttt aattgcgcag gaataaagac caattcttgt
    23341 cgttgaaggc tcgctccaat ctcttttaaa tcgtcctgac aatcagggca aatgctctct
    23401 tctacttgat gatgaacttc ttctgaatca aattgggcaa gaatagcttg acgtttccct
    23461 ttagctttct tacgtttata ggtgatttct tctctttcaa ctgggtaagt cagagtcttc
    23521 ttccatattt tgttcctctt caaaaagact gagttgtcca aaagggcaaa cacttttctc
    23581 agaggatttt ccatagagct tttgcgttag ataagccact tgttcacgca gaagggaaag
    23641 ttcattagtg agactatcaa ttatagcact ctgttgttga atgattttca atcttctccc
    23701 atagactttc ctccttattt cctaacttta ttatatagtg tattgaatct ataacagtac
    23761 accttgactg ctaaaatatt tctataaatt aatttgactt ttctgataga gatgttcata
    23821 tcttatttca attcactata ctaaaaagaa agtcctcatt tcaatagaaa tcacgacttt
    23881 ctgataaatt tattttggga gtgatagaaa agcccttcat aagccagtct atttgttcag
    23941 gtgtgagagc tttgacatcc ttttatgtac tggaccaagt cagtctgccg ttctcaaagc
    24001 gtttatatag tagccaaaat ccttgaccat cccagtaaag ggctttaaag cggtctttac
    24061 gtccaccaca aaagagaaaa acttgaccgg agaaaggatc taattcaaaa tgggttttaa
    24121 ccagataagc cagtgaatca atgccttgcc tcatatccgt tttcccacat acgagataga
    24181 cctgccctag gctagataga tgaattgtca tagagcaaca ccttatccaa aagctgttct
    24241 atcatttcga gattgagaga ttgaaaaaaa cttacttcaa gcttgccaat acgaatttta
    24301 agcagaatat catttctctt tttagaatca aaacgacgag attgtggaat ctctacagga
    24361 acaataggtt gtggcattaa aatatcctcc aatagtttta ctttactaat agtatacagg
    24421 aggagctcca tgaatgatag ataccttgtt atgacgcgct tactaaacaa ctaactgatg
    24481 cacgatttaa gcgccttgtt ggtgttcagc gcacgacttt tgaagagatg ttagctgtat
    24541 taaaaacagc ttatcaactt aaacacgcaa aaggtggacg aaaacctaaa ttaagcctag
    24601 aagaccttct tatggccact cttcaatatg tgcgagaata tcgaacttat gaagaaattg
    24661 cggctgattt tggtatccac gaaagcaact tactccgtcg gagccaatgg gttgaagtaa
    24721 ctcttgttca aagtggtgtt acgatttcaa gaactcctct cagttctgag gacacggtaa
    24781 tgattgatgc gacggaagta aaaatcaatc gccctaaaaa aagaattagc gaatgattct
    24841 ggtaaaaaga aatgccacgc tatgaaggct caagcgattg tcacaagtca agggagaatt
    24901 gtttctttgg atatcgctgt gaactattgt catgatatga agttgttcaa aatgagtcgc
    24961 agaaatatcg gacaagctgg aaaaatcttg gctgacagtg gttatcaagg gctcatgaag
    25021 atatattctc aagcacaaac tccacgtaaa tccagcaaac tcaagccgct aacagttgaa
    25081 gataaaacct ataaccatgc gctatctaag gagagaagca aggttgagaa catctttgcc
    25141 aaagtaaaaa cgtttaaaat gatttcaaca acctatcgaa atcatcgtaa acgcttcgga
    25201 ttacgaatga atttgattgc tggtattatc aatcatgaac taggattcta gttttgcagg
    25261 aagtctattg aaggatcttt tgctttagtt ccttggtcaa ggttgattat tttcacggag
    25321 cgcttccgat tgttttcata aaccatttgc gcatagtcag cagaataaat ctttttgaaa
    25381 cgtccctttc ctagacatta tagaactttc agattcatct gaatttacca aattaacaca
    25441 aaaattctga aaattctgtt gacatctttc tgaaaagagt ttataatgga gagaaagttt
    25501 taaaggagaa aatgatgaaa agttcaaaac tacttgccct tgcgggcgtg acattattg
//
