LOCUS       CR931691               20135 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain nr. 34371 (serotype 27).
ACCESSION   CR931691
VERSION     CR931691.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20135)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 20135)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..20135
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="nr. 34371"
                     /db_xref="taxon:1313"
     gene            <1..33
                     /gene="dexB"
                     /locus_tag="SPC27_0001"
     CDS             <1..33
                     /gene="dexB"
                     /locus_tag="SPC27_0001"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI33998.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZU9"
                     /translation="PWDAFCVELL"
     gene            192..362
                     /gene="aliB"
                     /locus_tag="SPC27_0002"
                     /pseudo
     CDS             192..362
                     /gene="aliB"
                     /locus_tag="SPC27_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(361..881)
                     /gene="tnp"
                     /locus_tag="SPC27_0003"
                     /pseudo
     CDS             complement(join(361..681,674..802,810..881))
                     /gene="tnp"
                     /locus_tag="SPC27_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1096..2550
                     /gene="wzg"
                     /locus_tag="SPC27_0004"
     CDS             1096..2550
                     /gene="wzg"
                     /locus_tag="SPC27_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI34001.1"
                     /db_xref="GOA:Q4K048"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K048"
                     /translation="MLIMSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1096..1221
                     /gene="wzg"
                     /locus_tag="SPC27_0004"
                     /note="Signal peptide predicted for SPC1360 by SignalP 2.0
                     HMM (Signal peptide probability 0.991) with cleavage site
                     probability 0.537 between residues 42 and 43"
     misc_feature    1309..1656
                     /gene="wzg"
                     /locus_tag="SPC27_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 9.8e-65"
     misc_feature    1834..2277
                     /gene="wzg"
                     /locus_tag="SPC27_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            2552..3283
                     /gene="wzh"
                     /locus_tag="SPC27_0005"
     CDS             2552..3283
                     /gene="wzh"
                     /locus_tag="SPC27_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI34002.1"
                     /db_xref="GOA:Q4K047"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K047"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTLYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEKDLVHIIASDMHNLDGRPPHMAEAYDLVT
                     QKHGEAKAQELFIDNPRKIVIDQLI"
     misc_feature    2555..3163
                     /gene="wzh"
                     /locus_tag="SPC27_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 3.1e-36"
     gene            3289..3984
                     /gene="wzd"
                     /locus_tag="SPC27_0006"
     CDS             3289..3984
                     /gene="wzd"
                     /locus_tag="SPC27_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI34003.1"
                     /db_xref="GOA:Q4K046"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4K046"
                     /translation="MMKEQNTTEIDVFQLVKTLWKRKLMILLVALVTGAGAFVYSTFI
                     VRPEYTSVTRIYIVNRNQGDKAGLTNQDLQAGTYLVKDYREIILSQDVLEKVAANLKL
                     DMPAKTLTSKVQVTVPADTRVVSISVKDKQPEEASRIANSLREVATEKIVAVTRVSDV
                     TTLEEARPATTPSSPDVRRNSMFGFLGGAAVTAIAVFLIELLDTRVKRPEDVEDVLQI
                     PLLGIIPDLDKMK"
     misc_feature    3310..3726
                     /gene="wzd"
                     /locus_tag="SPC27_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.1e-53"
     misc_feature    3832..3909
                     /gene="wzd"
                     /locus_tag="SPC27_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            3994..4695
                     /gene="wze"
                     /locus_tag="SPC27_0007"
     CDS             3994..4695
                     /gene="wze"
                     /locus_tag="SPC27_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI34004.1"
                     /db_xref="GOA:Q4K045"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4K045"
                     /translation="MPTLEISQAKLDFVKKVEENYNALCTNLQLSGDDLKVFSITSVK
                     LGEGKSMTSTSIAWTFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIPAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGGVNRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GKYGDYEKNKKYVEG"
     gene            4698..6065
                     /gene="wchA"
                     /locus_tag="SPC27_0008"
     CDS             4698..6065
                     /gene="wchA"
                     /locus_tag="SPC27_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34005.1"
                     /db_xref="GOA:Q4K044"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K044"
                     /translation="MNGKIVKSSLAIIQSFLVILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGVIYF
                     LTLHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATYRVEKVLDRLIESNEVVGEL
                     VAVSVLDKPDFQHDCLEVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIVGALVGLIL
                     CGLVSIVLVPLIRKDGGSTIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVLM
                     KDGAK"
     misc_feature    4698..4790
                     /gene="wchA"
                     /locus_tag="SPC27_0008"
                     /note="Signal peptide predicted for SPC1364 by SignalP 2.0
                     HMM (Signal peptide probability 0.902) with cleavage site
                     probability 0.355 between residues 31 and 32"
     misc_feature    5481..6062
                     /gene="wchA"
                     /locus_tag="SPC27_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 7.9e-158"
     gene            6069..7268
                     /gene="wchF"
                     /locus_tag="SPC27_0009"
     CDS             6069..7268
                     /gene="wchF"
                     /locus_tag="SPC27_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34006.1"
                     /db_xref="GOA:Q4K043"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4K043"
                     /translation="MPLSLVRREMKQSVYIIGSKGIPAKYGGFETFVEKLTEYQKDDN
                     IQYYVACMRENSAKSGFTADTFEYNGAICYNIDVPNIGPSRAIAYDIAAVNKAIELAK
                     ENKDEAPIFYILACRIGPFISGLKKKIRSIGGRLLVNPDGHEWLRAKWSLSVRKYWKF
                     SEQLMVKHADLLVCDSKNIEKYIQEDYKQYQPKTVYIAYGTDTTPSSLKSEDAKVRNW
                     HREKGVSENGYYLVVGRFVPENNYETMIREFMKSNSKKDFVLITNVEQNKFYDQLLKD
                     TGFDKDPRVKFVGTVYDQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLSLLLD
                     VGFNREVGEDGAIYWKKDELAHVIEEVERFDEGDISELDEKSSQRIADAFTWEKIVTS
                     YETIFNS"
     misc_feature    6711..7205
                     /gene="wchF"
                     /locus_tag="SPC27_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.0022"
     gene            7451..8479
                     /gene="whaK"
                     /locus_tag="SPC27_0010"
     CDS             7451..8479
                     /gene="whaK"
                     /locus_tag="SPC27_0010"
                     /note="member of homology group 199"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34007.1"
                     /db_xref="GOA:Q4K042"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K042"
                     /translation="MIHLSIIVPVYNTAIDKLEQCFQSIKTFMDKNSALNMECVIIDD
                     GSKGKVSDWCREFSETKADFKFYKKVNEGVSVARNMGISLSKGQYIIFVDSDDLLVSF
                     NELEQYLLDGKYDLIFSDLATDIQQKHMWKAFEGDSREIDFETVISRIVSDGTLNGPV
                     CKIIRKNLLDQHHIEFDKTMITGEDLVFLIHILLQKPKMYYISQCTYIYKLDTNTSNN
                     RLKNCSKVFIKNNVVAYKHMIQLINQFSSNQHKQIFEKRATEIYIKQLFNSLADLLEM
                     GLLSQELKDYTVQLLSELDKQTVDLIQGQKLSKSNLQLTVLLNKWWLLLAVASRMRIL
                     YLKIKNSL"
     misc_feature    7463..7960
                     /gene="whaK"
                     /locus_tag="SPC27_0010"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 6.8e-23"
     gene            8489..9613
                     /gene="wzy"
                     /locus_tag="SPC27_0011"
     CDS             8489..9613
                     /gene="wzy"
                     /locus_tag="SPC27_0011"
                     /note="member of homology group 249"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI34008.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K041"
                     /translation="MLPYLGVFFASSSLIALSEKIKKNQRLFFVILALALPCMLAGFR
                     ADHIGTDTGVYLMPTINAATSSHSFSEYLNTSWYRIWRFLSVKDFERGFTLVVYVTTK
                     LLGAFWTKFILELLMTTPTYLAIKKYGKYPAWLGMMVFYLTTYNSTLNMMRQSIAVAF
                     TLLGILYFIERNKKGFVTCLLLGCSFHTSGLVLLMIAAMFYFIKPNQQLDTLFSRRVE
                     LQKVALILVLGIASLFSLGVVSSILKIIGLGSYVNYIGGTFHFVQNQFLSRFPIMLLM
                     LISWYKWNEGESYARFFIVMFILEVLCLQLTSVNVYSGRIAYFFSSMNVLTYPSLCYC
                     RPQKGRRFFMISALLVYLFFYWWFYYGIQGIDATIPYMMI"
     misc_feature    8489..8623
                     /gene="wzy"
                     /locus_tag="SPC27_0011"
                     /note="Signal peptide predicted for SPC1367 by SignalP 2.0
                     HMM (Signal peptide probability 0.877) with cleavage site
                     probability 0.373 between residues 45 and 46"
     gene            9630..10739
                     /gene="whaL"
                     /locus_tag="SPC27_0012"
     CDS             9630..10739
                     /gene="whaL"
                     /locus_tag="SPC27_0012"
                     /note="member of homology group 200"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34009.1"
                     /db_xref="GOA:Q4K040"
                     /db_xref="InterPro:IPR007345"
                     /db_xref="UniProtKB/TrEMBL:Q4K040"
                     /translation="MEIFVRGFFHVNLGDDLFLYILAKRYPNHNFHVILNEEYTKVFR
                     DEKNIIVHPYKKIRRGLDRFLINCNKDYYVEIEKKCQLNVVIGGSIFQENVDDVVARE
                     RLARMPQLNPTYILGANFGPYVTEEYRLLVKDYLTKSEDVCFRDEWSKQKFPELTKVR
                     FAPDIVFGIQSIIPKVNEKKKRIFVSVVDCFKKAGGIKKYAPNYEAFILRCINYYNEQ
                     GYEIILSSFCKMEGDKEVIDRILEKLPSDKQSEISILNYNGENWREVVAAIQQSEKII
                     ASRFHSMILGMVFGVSVLPIAYNKKFKQFLANFDLSHYCISVSDIDHQVPKNLNYLLF
                     DGNTDIAEQANEHFMKLDERLMRGTLWNNEYYKNK"
     gene            10717..12207
                     /gene="wzx"
                     /locus_tag="SPC27_0013"
     CDS             10717..12207
                     /gene="wzx"
                     /locus_tag="SPC27_0013"
                     /note="member of homology group 250"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI34010.1"
                     /db_xref="InterPro:IPR004268"
                     /db_xref="UniProtKB/TrEMBL:Q4K039"
                     /translation="MSTTKISNQNKKTAIQLTLMIILTCLSQIVALYKSRFTAVNFGA
                     TDYMDAYNFSLEIATFIFSFMTGGVTTVIIPAYVKKNSSKAVNTFITLTYGCILLLSV
                     GIIIFRTPLLSSLTVRGTDFIAIASGFLIVSFVIQGILSLLAVTTAYYQSEDRYNIPK
                     IIVLIVNMIVLTILLLGVIDNIYLYFSLLIAGSVLNLILDFIVAIKIGFRYKFCFDFK
                     NPEFKNMLIVFLPTVLSSGVYKLHTMVDTTIATNLAEGQATILTYASQIITMVNTVIV
                     GNLTVYVYPKIIANLKSKNTSKYFWDYCILFHAVLAIIIAGFINVGFEGLSLLFVGGK
                     FTLENANVLYMCACIYISGQQFNVIRDLIYRYFYANSNTKETFKNSVIVSIINIILSL
                     LLVSLFRVYGIVLGTVLSNMISLALIYIRFKKNFGIDVKISYISIEIIKNILAMVGSV
                     IVIHWLKTFLAINNNILSIIVYGTGTVIVYLVLILLLQTKIRHIKL"
     misc_feature    10717..10815
                     /gene="wzx"
                     /locus_tag="SPC27_0013"
                     /note="Signal peptide predicted for SPC1369 by SignalP 2.0
                     HMM (Signal peptide probability 0.853) with cleavage site
                     probability 0.554 between residues 33 and 34"
     misc_feature    10834..12138
                     /gene="wzx"
                     /locus_tag="SPC27_0013"
                     /note="HMMPfam hit to PF03023, MviN-like protein, score
                     1.6e-11"
     gene            12333..13289
                     /gene="wcyS"
                     /locus_tag="SPC27_0014"
     CDS             12333..13289
                     /gene="wcyS"
                     /locus_tag="SPC27_0014"
                     /note="member of homology group 118"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34011.1"
                     /db_xref="GOA:Q4K038"
                     /db_xref="InterPro:IPR008441"
                     /db_xref="UniProtKB/TrEMBL:Q4K038"
                     /translation="MSIFATLIKKKGAEIFKNLIQSRVLFRTIAILPLVGFSKKSLEI
                     VRLNNSNIVLSRLRRNYRSAIQKFREENQYSLVYDQQDSSTSSKIWICWFQGLDVAPH
                     VVRECIASVRKQLADREVVVLTDDNYHHYVTFPDHIKAKIDQGIISKTHLSDLLRLEL
                     LTKYGGTWIDGTVFCSSSDIPVYMLDSDLFLFQNLKPGLDGQALAISTWFMTAAKLHH
                     PLLELTKDLLYLYWKKNNTMVDYFLIHHFFQLSIEEFPEYWSRVVPFNNSTPHILQLR
                     LFEEFDETMYRHILEQTPFHKLTYKFEGEKSSIPNTYYKHLF"
     misc_feature    12468..13283
                     /gene="wcyS"
                     /locus_tag="SPC27_0014"
                     /note="HMMPfam hit to PF05704, Capsular polysaccharide
                     synthesis protein, score 1.4e-64"
     gene            13366..14187
                     /gene="wcrN"
                     /locus_tag="SPC27_0015"
     CDS             13366..14187
                     /gene="wcrN"
                     /locus_tag="SPC27_0015"
                     /note="member of homology group 119"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI34012.1"
                     /db_xref="GOA:Q4K037"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4K037"
                     /translation="MKELTTREMQEVSLEILHTIASICEKQHLRYALIYGTLIGAVRH
                     KGYIPWDDDVDIMMPRPDYDSLLQYLKENIADYPYLKVFNREECPEYPYMITRISDQR
                     YRIEMENEKPFGLGVFIDIYPYDGLGDTKQESVAFGLKGDRLSSFCYQATREHFAIET
                     TISAFRKFIKYPVYLFSKMIGKNYFQSQLDKLARVKDYDNSNFVGCVIWLSWGEKDIF
                     PREWFDETILVPFEKYEFRIPKEFDKILRHEYGDYMILPPEKDRVGHHYFKAYKK"
     misc_feature    13435..14118
                     /gene="wcrN"
                     /locus_tag="SPC27_0015"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     7.3e-42"
     gene            14347..14613
                     /gene="HG270"
                     /locus_tag="SPC27_0016"
                     /pseudo
     CDS             14347..14613
                     /gene="HG270"
                     /locus_tag="SPC27_0016"
                     /note="member of homology group 270"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative transferase (fragment)"
     misc_feature    14350..14403
                     /gene="HG270"
                     /locus_tag="SPC27_0016"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 0.18"
                     /pseudo
     misc_feature    14434..14487
                     /gene="HG270"
                     /locus_tag="SPC27_0016"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 0.26"
                     /pseudo
     misc_feature    14488..14541
                     /gene="HG270"
                     /locus_tag="SPC27_0016"
                     /note="HMMPfam hit to PF00132, Bacterial transferase
                     hexapeptide (three rep, score 0.019"
                     /pseudo
     gene            15021..15953
                     /gene="rmlA"
                     /locus_tag="SPC27_0017"
     CDS             15021..15953
                     /gene="rmlA"
                     /locus_tag="SPC27_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI34014.1"
                     /db_xref="GOA:Q4K036"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K036"
                     /translation="MILVYKHGKIKVQITKKGTPFMKGIILAGGSGTRLYPLTRAASK
                     QLMPVYDKPMIYYPLSTLMLAGIRDILIISTPQDLHRFQELLQDGSEFGIKLSYAEQP
                     SPDGLAQAFIIGEEFISDDSVALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKD
                     PERFGVVEFDQDMKAISIEEKPEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEI
                     TDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIA
                     YRMGYISRKDVLTLAQPLKKNEYGQYLLRLIGEA"
     misc_feature    15087..15803
                     /gene="rmlA"
                     /locus_tag="SPC27_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.2e-120"
     gene            15954..16547
                     /gene="rmlC"
                     /locus_tag="SPC27_0018"
     CDS             15954..16547
                     /gene="rmlC"
                     /locus_tag="SPC27_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI34015.1"
                     /db_xref="GOA:Q7BTQ6"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q7BTQ6"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
     misc_feature    15990..16520
                     /gene="rmlC"
                     /locus_tag="SPC27_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            16560..17609
                     /gene="rmlB"
                     /locus_tag="SPC27_0019"
     CDS             16560..17609
                     /gene="rmlB"
                     /locus_tag="SPC27_0019"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI34016.1"
                     /db_xref="GOA:Q4K034"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K034"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPGVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGERPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    16575..17531
                     /gene="rmlB"
                     /locus_tag="SPC27_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00011"
     misc_feature    16578..17318
                     /gene="rmlB"
                     /locus_tag="SPC27_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 3.3e-76"
     misc_feature    16581..17393
                     /gene="rmlB"
                     /locus_tag="SPC27_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.7e-05"
     gene            17675..18526
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
     CDS             17675..18526
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI34017.1"
                     /db_xref="GOA:Q4K2P3"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K2P3"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVNPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    17675..18523
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 5.7e-148"
     misc_feature    17678..18307
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 5.6e-19"
     misc_feature    17678..18319
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0001"
     misc_feature    17681..18409
                     /gene="rmlD"
                     /locus_tag="SPC27_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.9e-08"
     gene            order(18602..19555,19566..19784)
                     /gene="tnp"
                     /locus_tag="SPC27_0021"
                     /pseudo
     CDS             join(18602..19555,19566..19784)
                     /gene="tnp"
                     /locus_tag="SPC27_0021"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    18608..19051
                     /gene="tnp"
                     /locus_tag="SPC27_0021"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 0.00049"
                     /pseudo
     gene            19983..>20135
                     /gene="aliA"
                     /locus_tag="SPC27_0022"
     CDS             19983..>20135
                     /gene="aliA"
                     /locus_tag="SPC27_0022"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34019.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0S2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYL"
     misc_feature    19983..20069
                     /gene="aliA"
                     /locus_tag="SPC27_0022"
                     /note="Signal peptide predicted for SPC1381 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
BASE COUNT     6392 a   3242 c   4213 g   6288 t
ORIGIN
        1 ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa atttaaaatt
       61 gaaatcgtat aaaaacaagg gaggactgta taaaaagcag aaatcctttg ttttttataa
      121 ccaaggttta taaactttca ttctcgaaat tcaattaact ttacaaattc ccactattga
      181 ggagaaagaa gatgaacata aagaagcgtg tccttagtgc aggcctgact tttgcatctg
      241 ttttgctttt agttgcttgc ggccaatcag gttcagatac aaaaacttac tcatcaacct
      301 ttagtggaaa tccaactaca tttaactatc tattagacta ttacgctgat aatatagtta
      361 attgaaacaa gagcaggaca aaagagcctc gtaaaaggta ttgcaacttg gtaatacctt
      421 tttgaggtgc tttttgatat gagcctatgt tttctcaata ggattgtatt caggcgagta
      481 gggaggaaga ggtaaaagtt tatgcccaaa ctcttcgcac aagagttcta gcttccccat
      541 tctatggaat cttacattat ccataataat aaccgatagt gtggttaatg ttggtaagag
      601 aaacttctga aaccaagctt caaaaaagtc gctcgtcatc gtctcttcgt aagtcattgg
      661 agcgattaac tcaccattca tttgttagac ctgcaaccaa agaaatcctc tgatatcttc
      721 ttccagatac tttgcctctt cttaactgac cttttaatga gcgaccatat tctcgataaa
      781 aataagtatc gaatcctgtt tccaatataa acaggtgcta ggtgctttaa actattaaaa
      841 ttcttaagaa atatggctac tttttctggg tcttgttcat aattagattg aaactagaat
      901 agtacacatc tgcttctaaa acattgttag aaaacgattt gactgtcctg aacaatttgt
      961 catgttcttg tttcatttta ctatattttt ggttcgcggg aagtctacta agatacttaa
     1021 agatgcagat agtgaaaaaa aggtgtagac attaccgtaa aaaagtgata taatcgtata
     1081 atgttcaatg tataggtgtt aatcatgagt agacgtttta aaaaatcagg ttcacagaaa
     1141 gtgaagcgaa gtgttaatat cgttttgttg actatttatt tattgttagt ttgtttttta
     1201 ttgttcttaa tctttaagta caatatcctt gcttttagat atcttaatct agtggtaact
     1261 gcgttagtcc tactagttgc cttggtaggg ctactcctga ttatctataa aaaagctgaa
     1321 aaatttacta tttttctgtt ggtgttctct atccttgtca gctctgtgtc gctctttgca
     1381 gtacagcagt ttgttggact gaccaatcgt ttaaatgcga cttctaatta ctcagaatat
     1441 tcaatcagtg tcgctgtttt agcagatagt gagatcgaaa atgttacgca actgacgagt
     1501 gtgacagcac cgactgggac tgataatgaa aatattcaaa aactactagc tgatatcaag
     1561 tcaagtcaga ataccgattt gacggtcgac cagagttcgt cttacttggc agcttataag
     1621 agtttgattg caggtgagac taaggccatt gtcttaaata gtgtctttga aaatatcatc
     1681 gagtcagagt atccagacta tgcatcgaag ataaaaaaga tttataccaa gggatttact
     1741 aaaaaagtag aagctcctaa gacgtctaag aatcagtctt tcaatatcta tgttagtgga
     1801 attgacacct atggtcctat tagttcggtg tcgcgatcag atgtcaatat cctgatgact
     1861 gtcaatcgag ataccaagaa aatcctcttg accacaacac cacgtgatgc ctatgtacca
     1921 atcgcagatg gtggaaataa tcaaaaagat aaattaaccc atgcgggcat ttatggagtt
     1981 gattcgtcca ttcacacctt agaaaatctc tatggagtgg atatcaatta ctatgtgcga
     2041 ttgaacttca cttctttctt gaaaatgatt gacttattgg gaggggtaga tgttcataat
     2101 gatcaagagt tttcagctct acatgggaag ttccatttcc cagtagggaa tgtccatcta
     2161 gactctgagc aggctctagg ttttgtacgt gaacgctact cactagcaga tggcgatcgt
     2221 gaccgcgggc gcaatcaaca aaaggtcatt gtggctatcc ttcaaaaatt aacgtcaacc
     2281 gaagcactga aaaattatag tacgatcatt aatagcttgc aagattctat ccaaacaaat
     2341 atgccacttg agactatgat aaatttggtc aatgctcagt tagaaagtgg agggaattat
     2401 aaagtaaatt ctcaagattt aaaaggtaca ggtcggatgg atcttccttc ttatgcaatg
     2461 ccagacagta acctctatgt gatggaaata gatgatagta gtttagctgt agttaaagca
     2521 gctatacagg atgtgatgga aggtagatga aatgatagac atccattcgc atatcgtttt
     2581 tgatgtagat gacggtccca agtcaagaga ggaaagcaag gctctcttgg cagaatccta
     2641 caggcagggg gtgcgaacca ttgtctctac ctctcaccgt cgcaagggca tgtttgaaac
     2701 tccggaagag aagatagcag aaaactttct tcaggttcgg gaaattgcaa aagaagtagc
     2761 agatgattta gtcattgctt atggggctga aatttactac acaccagatg ttctggataa
     2821 gctggaaaaa aagcggattc cgaccctcaa tgatagtcgt tatgccttga tagagtttag
     2881 tatgaacact ctttatcgcg atattcatag cgccttgagc aagatcttga tgttgggaat
     2941 tactccagtc attgcccaca tcgaacgcta tgatgctctt gaaaataatg aaaaacgcgt
     3001 tcgggaactg atcgatatgg gttgttacac gcaagtaaat agttcacatg tcctcaaacc
     3061 caaacttttt ggcgaacgtt ataaattcat gaaaaaaaga gctcagtatt ttttagagaa
     3121 ggatttggtt catatcattg caagtgatat gcacaatcta gacggtagac ctcctcatat
     3181 ggcagaagca tatgaccttg ttacccaaaa acacggagaa gcgaaggctc aggaactttt
     3241 tatagacaat cctcgaaaaa ttgtaataga tcaactaatt taggagaaat gatgaaagaa
     3301 caaaacacga cagaaatcga tgtatttcaa ttagttaaaa ccttgtggaa acgcaagcta
     3361 atgattttat tagtggcact tgtgacaggt gcgggggctt ttgtatatag cacttttatt
     3421 gttaggccag aatatacgag tgtcacgcga atttacatag tgaatcgcaa tcaaggagac
     3481 aaggcggggc tgacaaatca ggatttgcaa gcaggaactt atctggtaaa agactaccgt
     3541 gagattatcc tttcgcagga tgtattggaa aaagtagcgg caaatttgaa gttggatatg
     3601 ccagcaaaaa cgttaaccag caaagttcaa gtgactgtac cagctgacac tcgtgtcgtc
     3661 tcaatctctg tcaaggataa acagccagag gaagccagtc gtatcgctaa ttctctacga
     3721 gaagttgcta cagaaaagat cgtcgctgta acgcgagtat ctgatgtaac gacacttgaa
     3781 gaagcgcgac cagctacgac tccctcttct ccagatgttc gacgcaattc catgtttggt
     3841 tttcttggag gagcagccgt aacagcaatt gctgtttttt tgattgagtt gctcgacacc
     3901 cgtgtaaaac gtcctgaaga tgtcgaagat gtactgcaaa ttccactttt agggatcatt
     3961 ccagatttgg acaaaatgaa ataggaggaa attatgccaa cgttagaaat ttcacaggca
     4021 aaattggatt ttgtaaaaaa ggtagaggaa aattataacg ctttgtgcac gaacctacag
     4081 ttaagtggag atgatttgaa agtattttct atcacttctg tgaaactagg agaaggaaaa
     4141 tcaatgactt ccaccagtat cgcttggact tttgcgcgtg caggttacaa aacgctgctg
     4201 attgatggag atattcgcaa ttctgttatg ttaggtgtct ttaaagcaag ggataagatt
     4261 acaggcctga cagaattttt atcaggaact acagacctat cacaagggct ttgtgatacc
     4321 aatatcgaaa atctctttgt aattccggct ggctctgtgt caccgaatcc gacagctctt
     4381 cttcaaagta agaatttcag tacaatgctt gaaaccttgc gtaaatattt tgactacatc
     4441 attgtagata ctgctcctgt cggtgtcgtg attgatgcgg ctattattac gcgaaaatgc
     4501 gatgcttcta ttttagtgac ggaggcaggt ggagtaaatc gacgggatat tcaaaaagca
     4561 aaagaacagt tggaacacac agggaagccg tttttgggag ttgtgttgaa taaattcgat
     4621 acttcagtag acaaatacgg ttcttatgga aaatatggag attacgagaa aaataaaaaa
     4681 tatgttgagg gatagagatg aatggaaaaa tagtaaagtc ttcattggcc ataatccaga
     4741 gttttcttgt tattttattg acttatctac ttagtgctgt gagagaagcg gagattgttt
     4801 caacaacagc tattgcactt tatatcctcc attattttgt cttttatatc agtgattatg
     4861 gacaggattt ctttaaaagg ggatatttga ttgaacttgt ccagacattg aaatatatcc
     4921 tattctttgc actagcgatt agtatttcta attttttctt agaggatcga tttagtattt
     4981 ccagacgagg cgtgatttac ttcctcacat tacatgctct cttagtctat gtgctaaacc
     5041 tatttatcaa gtggtattgg aagcgggctt atcccaactt taaaggaagt aagaagattc
     5101 tcctacttac agcaacttat cgtgtcgaaa aggtactgga tagattaata gaatcaaatg
     5161 aggttgttgg ggagttggta gccgtcagtg tcttagataa accagatttt cagcatgatt
     5221 gtttagaagt agtagcagag ggggagatag taaactttgc gactcatgag gtggtcgatg
     5281 aagtctttat caatcttcca agtgaaaaat acaatattgg agagcttgtc tctcagtttg
     5341 aaacgatggg aattgatgta acagtcaatc taaatgcttt tgatcgtagt ttggcacgta
     5401 acaagcaaat tcgtgagatg gcaggattaa acgttgtgac tttttctaca acattttata
     5461 agactagtca tgtaattgct aagcggatta ttgatatcgt gggtgcattg gtagggctga
     5521 tactatgtgg tttagtcagt attgtactgg ttcctttgat tcgaaaggat gggggctcta
     5581 ctatttttgc tcagacgcgt ataggaaaaa atggtcgtca gttcactttt tataagtttc
     5641 gctctatgtg tgtagatgcc gaggcgaaaa aaagagaact catggaacaa aataccatgc
     5701 agggtggaat gtttaaggtg gacgatgatc ctcgtatcac gaaaattggt cgttttatac
     5761 ggaagactag cttggacgag ctaccacagt tttataatgt tctaaaggga gatatgagtt
     5821 tggttggcac acgaccacca acagtggacg agtatgaaca ctatacccca gaacaaaaac
     5881 gtcggctaag ttttaaacct ggtataacag gcttatggca ggtcagtgga cgaagtgaga
     5941 ttaagaattt tgatgaagtt gtcaaattag atgtagccta tatagacgat tggacaattt
     6001 ggaaagacat tgaaatttta ttgaagacag ttaaagttgt attgatgaag gatggagcga
     6061 agtgattttt gcccctcagt cttgttagga gagagatgaa acagtcagtt tatatcattg
     6121 gttcaaaggg gattcctgcc aagtatggag gatttgaaac ctttgttgaa aaattaacag
     6181 aatatcaaaa agatgataac atccaatact atgttgcctg catgcgtgaa aattcggcaa
     6241 agtcaggatt tacagcagat acatttgagt acaacggtgc tatttgttac aacattgatg
     6301 tgcctaatat tggtccttct agagccattg cttacgatat tgcagcggtc aataaggcta
     6361 ttgaattggc taaggaaaac aaggacgagg ctcccatttt ttacattcta gcttgtcgta
     6421 tcgggccttt tatttctgga cttaagaaaa aaattcgttc gatcggaggc cgactactgg
     6481 taaatccaga tggccatgag tggctccggg ctaaatggag cctgtcagtt cggaagtatt
     6541 ggaagttttc ggaacagttg atggtcaaac atgcagattt attagtctgt gatagcaaaa
     6601 atatcgaaaa atatatccaa gaggactata aacagtatca gcctaaaacg gtctatatcg
     6661 cttatggcac agatactacc ccctcgagcc tgaaatcaga agatgccaaa gttcgaaact
     6721 ggcatcgtga aaagggagta agcgaaaatg gctattatct agtggtggga cgattcgttc
     6781 ccgaaaacaa ctatgaaacc atgattcgtg aatttatgaa gtctaattct aaaaaagact
     6841 ttgttctcat tacaaatgta gaacaaaata agttttacga tcagttgctc aaggatacag
     6901 gcttcgacaa agatccaaga gtcaaatttg tgggaacagt ctatgaccaa gaattgctca
     6961 agtatatccg tgaaaatgct ttcgcctatt tccatggaca tgaagttggg ggtaccaatc
     7021 catcgcttct tgaagcttta gcatccacta aacttagctt gttgttggat gtcggcttta
     7081 accgtgaagt tggtgaagac ggagccattt attggaaaaa agatgagcta gcgcatgtaa
     7141 tcgaagaagt ggaacgattt gatgaaggtg atatttcgga attagacgaa aagtctagcc
     7201 aacgaattgc ggatgcattt acgtgggaaa agattgtcac tagctatgag acgattttca
     7261 attcgtgaaa cgtattaata gatggtagaa ttatctccta ttgatttttt actattgcgc
     7321 taattcattt actgtatctt gttattgttt caggctttta gtaaatgata cgattggata
     7381 atggttttac gatattattc tggaatgttg tgagagataa gctaatattt ttgaagagaa
     7441 agaggagagt atgatacatt tgagcatcat tgttcctgtt tacaatacag ctatagataa
     7501 attagaacaa tgctttcagt ctatcaaaac ttttatggat aagaatagtg ccttaaatat
     7561 ggaatgtgtt atcattgatg acggttcaaa gggtaaggta tctgattggt gtcgagagtt
     7621 ttcagagaca aaggctgatt ttaaatttta taaaaaagtt aacgaaggtg ttagcgtagc
     7681 gagaaatatg gggattagcc tttctaaagg acaatacatt atcttcgttg attcagatga
     7741 tcttcttgtt tcctttaatg agctggagca gtatcttttg gatggcaagt atgaccttat
     7801 ttttagcgat ttagcgactg atatccaaca aaagcatatg tggaaggcgt ttgaaggtga
     7861 ctcacgcgag atcgattttg agacagtaat tagtagaatt gtcagcgatg ggaccttaaa
     7921 tggtcctgtt tgcaagatta tcagaaaaaa tttgttagac caacaccata tagagttcga
     7981 caaaacgatg ataacgggag aagatttggt ttttttaatt catatcttat tacaaaaacc
     8041 taaaatgtat tatatttctc aatgtaccta tatctataaa ttagacacaa atacgtctaa
     8101 caaccgcttg aaaaattgct cgaaagtttt tataaaaaat aatgttgttg cctataaaca
     8161 tatgattcag ttgattaatc aattttccag caatcaacat aaacaaatat ttgaaaaaag
     8221 ggcaacagag atatatataa agcaattatt caattctctt gcagatttgc tagaaatggg
     8281 cttgttgtcg caagagttaa aagactacac agtacagttg ttgtcagagt tggataagca
     8341 gacagtagat ttgattcaag gacaaaaact gtctaaatca aatttgcaat taacagtatt
     8401 actcaacaag tggtggctac tgttagcagt agctagtaga atgaggattc tatacttgaa
     8461 aattaaaaat agcttataag gagtagggat gttaccttat cttggtgtct tttttgcctc
     8521 tagttctttg atagcattgt cagagaaaat aaagaaaaat caaagacttt tttttgttat
     8581 attagcttta gctctcccat gcatgcttgc aggatttaga gcagatcata ttggaactga
     8641 tacaggggtt tacttaatgc cgacgattaa tgcagccacc tcttctcatt ctttttcaga
     8701 atatttgaat actagttggt atagaatttg gcgtttttta tccgtaaaag attttgaacg
     8761 aggtttcaca cttgtagtct atgtaactac aaaattatta ggcgctttct ggacaaagtt
     8821 tattttggaa ctgcttatga caactccaac ctatctagct ataaaaaaat atgggaaata
     8881 tccagcatgg ctagggatga tggtgtttta tcttactacc tataattcaa ccttgaatat
     8941 gatgagacaa tcaatagcag tcgcattcac tttattggga attttatact ttattgagag
     9001 aaataagaag ggctttgtta cttgtttatt gttgggttgt tccttccata cttctgggct
     9061 tgttttgtta atgattgcag cgatgtttta ctttataaaa ccaaatcagc aacttgacac
     9121 gctattctca aggagagttg agcttcaaaa agttgctctc atactggttt taggtatagc
     9181 ctccctgttt tccttaggag tagtgtctag cattttaaaa attataggtt taggaagcta
     9241 cgtaaattat attggcggaa catttcattt tgtacagaat caattcttga gtcggtttcc
     9301 aattatgctc cttatgctta tcagctggta taagtggaat gaaggggaaa gttatgctag
     9361 atttttcata gtgatgttta ttctagaggt cttgtgtttg caactaacta gtgtaaatgt
     9421 atactcagga agaattgcct actttttctc ttctatgaat gttttgacct atccttcctt
     9481 gtgttactgc agaccgcaaa aagggcgtcg ctttttcatg attagtgcct tacttgtcta
     9541 ccttttcttt tattggtggt tttactatgg aatacaagga atagatgcga ctattccata
     9601 tatgatgata taaggaggaa gtatatataa tggaaatatt tgtcagaggt ttttttcatg
     9661 ttaatttagg tgacgatcta tttttgtata ttcttgcaaa acgatatcca aatcataatt
     9721 ttcatgtgat tcttaatgaa gaatatacaa aggtatttcg tgatgaaaaa aatatcattg
     9781 tccatccata taaaaaaata agaagaggct tagatcgttt tttaattaac tgtaataaag
     9841 attactatgt agaaatagag aaaaagtgcc aactcaatgt tgtgattggg ggatctattt
     9901 ttcaggaaaa tgtagatgat gtggttgctc gtgaacgttt agctagaatg cctcaattaa
     9961 atcctactta tattttagga gcaaatttcg gtccctatgt aacggaagag tatcgcttgc
    10021 ttgttaaaga ttatcttact aaatcagaag atgtctgttt ccgtgatgaa tggtccaagc
    10081 aaaaatttcc agaattaaca aaggttcgtt ttgcaccaga tattgttttt gggatacaga
    10141 gtatcattcc gaaagtgaac gagaaaaaga aaagaatttt tgtttctgtc gtagactgtt
    10201 ttaaaaaagc tggaggcata aaaaaatatg cccccaacta tgaggcattt attcttcgtt
    10261 gcataaatta ttataatgaa caggggtatg aaattatcct ctcttctttt tgtaaaatgg
    10321 aaggtgataa agaggtaatt gatagaattc tagagaagct accatcagat aaacaatctg
    10381 aaatatctat tttgaattat aatggagaga attggagaga ggtcgttgct gctattcaac
    10441 aatcagaaaa aatcattgct tcacgattcc atagcatgat tctcggcatg gtctttggtg
    10501 tgtcagttct ccctattgct tataataaaa aattcaaaca atttttagca aattttgact
    10561 tatctcacta ttgtatttcg gtttcagata tagatcatca agtgcccaaa aatttgaatt
    10621 atttattatt tgacggaaat acggatatag ctgaacaagc taatgaacac tttatgaaac
    10681 tagatgaacg actaatgaga ggcacacttt ggaataatga gtactacaaa aataagtaat
    10741 caaaacaaaa aaacagctat tcaattaacc ttgatgatta tactaacgtg cttgtctcaa
    10801 attgtggcct tatataaatc taggtttaca gctgttaact ttggtgcaac cgactacatg
    10861 gatgcttaca atttttcttt agaaattgca acatttattt tttcatttat gacgggcgga
    10921 gtaaccactg taataattcc ggcttatgtg aaaaaaaatt cttctaaagc agtgaatact
    10981 ttcatcaccc ttacctacgg ttgtatctta ttgttaagtg tggggattat tatctttcga
    11041 acacctttac tatcttcgct aactgtcaga gggactgact ttatagctat cgcttcaggt
    11101 tttttgatag tttcatttgt gattcaaggc attctatctt tgttagctgt aaccacggcc
    11161 tactatcagt ctgaggatag atataatatc ccaaagataa tcgtgctgat tgtcaatatg
    11221 attgtattaa ctattttact gcttggggtg attgataata tctatttata cttctcgctt
    11281 ttgattgcgg gatcagttct caatttgatt ttagatttta ttgttgctat caaaataggc
    11341 tttagataca agttctgctt tgatttcaag aatccagaat ttaaaaatat gctgattgta
    11401 tttttgccaa ccgtattaag ttcaggagtt tataagttgc atacaatggt agatactacg
    11461 attgcaacga atttagcaga aggacaggct acaatcctaa cttatgcttc acagatcatt
    11521 acgatggtaa atacggttat tgttgggaat ttaacagtgt atgtctatcc taaaatcata
    11581 gcaaatttaa agagtaaaaa tacatctaaa tatttttggg attattgcat acttttccat
    11641 gctgtcttag cgattattat tgcaggtttt ataaatgttg gttttgaagg actatcttta
    11701 ctatttgttg gtgggaaatt tacacttgaa aatgcgaatg ttctttatat gtgtgcctgt
    11761 atttatatca gcgggcaaca gtttaatgtt atccgtgact tgatttatcg atatttttac
    11821 gcaaattcca acacaaaaga aacctttaag aatagtgtta tcgtcagcat cataaatatt
    11881 atactgagct tgttgttggt tagtcttttt agagtttatg gtattgttct tggaaccgtg
    11941 ttatctaata tgatttcgct tgctctcatc tatattcgct ttaaaaagaa tttcggtata
    12001 gatgtaaaga ttagctatat atccattgag ataattaaaa atattttggc aatggtagga
    12061 tcagtcatcg ttatacattg gctaaagact ttcttagcta tcaataataa tattttatct
    12121 attattgtat atggtaccgg gacagttata gtatatttgg tactgatttt gctattacag
    12181 acaaaaataa gacacataaa attataagaa acatagggac tacactatct aaagaaaata
    12241 ctaggtattg ttgagatatc cttaatattt ttcttaaagg ttcaacacga atataccaga
    12301 atatatgctt atggtttaga aaggatgttt tagtgagtat ttttgccaca ttgattaaaa
    12361 aaaagggtgc agagattttt aaaaacttaa tacaatcaag agtgcttttt cgaacgatag
    12421 ctattttacc gctggttggt ttttcaaaaa aatcattaga gatagtccgt ctaaataata
    12481 gcaatatagt tctttcaaga ttgagaagga actatagatc cgctattcaa aaatttagag
    12541 aagaaaatca gtattcactt gtgtatgacc agcaagatag tagcacttcc tcaaagatat
    12601 ggatttgttg gtttcaagga ttagatgttg cccctcatgt agttcgggag tgtatcgctt
    12661 cggtaagaaa gcagctagca gacagagaag tggttgtttt aacagacgat aattaccatc
    12721 actatgtgac tttcccagat cacattaaag caaaaattga tcagggaatt atttccaaga
    12781 ctcacttgtc agatttattg cgtttggagt tgctgactaa atatggtggg acatggattg
    12841 atggaacagt attttgttcg agttccgata ttcccgttta tatgctagat tctgatttat
    12901 ttctgtttca aaatttaaaa ccgggtcttg atgggcaagc tttggctatt tcaacttggt
    12961 ttatgacagc tgctaaactt catcatccac ttttagagtt aacaaaggat ttgctttatc
    13021 tgtactggaa aaagaataac acgatggttg actattttct aatccaccac ttcttccagt
    13081 tatctatcga agagtttcct gaatactgga gtagagtagt tcctttcaat aattcaactc
    13141 ctcatatttt gcagttgcgc ttatttgaag agtttgacga aacaatgtat cgtcatattc
    13201 ttgaacagac accattccat aagctaacat acaaatttga aggagaaaag tcaagcatac
    13261 cgaatactta ctataaacac ttattttgat aaaaatgatc gtagttgatt taaaaactgc
    13321 tgttaggtat agaacataat taagatatta tcgggagggt acgatatgaa agaactaact
    13381 actcgagaga tgcaagaagt atcgttggag attttacata cgattgctag tatttgtgaa
    13441 aagcaacatt tgcgctatgc tttgatttat ggaaccttaa tcggtgcggt tagacataaa
    13501 ggttatattc cttgggatga tgacgttgac attatgatgc cccgacccga ttatgatagt
    13561 ctattacaat acttgaagga aaatatcgct gattatccat atttaaaagt atttaatcgc
    13621 gaagagtgcc cagaatatcc ctacatgatt actagaatta gcgatcagag ataccggatt
    13681 gagatggaaa acgagaaacc ttttggttta ggagttttca tcgatatcta tccctatgat
    13741 ggtttgggag atacgaaaca agaatcggtt gccttcggtt tgaaggggga tcgtttatca
    13801 tcattttgtt atcaggcaac tagagaacat tttgcgattg aaacgacaat atcagctttt
    13861 aggaagttta ttaaataccc ggtttatctg ttttctaaaa tgattggaaa aaattacttt
    13921 caaagtcaat tagataagtt agcgagagtc aaagattatg acaacagtaa ctttgttggt
    13981 tgtgtgattt ggttgtcatg gggagaaaaa gacatctttc cacgtgagtg gtttgatgag
    14041 actattttgg tcccttttga aaaatatgaa tttagaatcc ctaaagagtt tgacaaaatt
    14101 ttgcgacatg aatatggaga ttatatgatt ttacctcctg aaaaggatag ggtgggacat
    14161 cactatttta aagcttataa aaaatgataa tttgctaagc aaagaaaagg aaaatcatga
    14221 aattatttta tttacaattg gagtaggaag tttaaaggtg gagtttctct gctcagagtt
    14281 ctatatgatt tcgagtgccc gcgtaaagct aaaattggga ataacgtcaa tttttcacat
    14341 cgtgggatgg gaacagttgt aagtagtaat gctatcatcg ggaacaatgt gaccatacaa
    14401 catcatgtaa cattagggat taaaaacgat gatagaatta tcatcgggga gaactgtttt
    14461 ataggagcct atgcatttat cttgggaaat gtaaaaattg gtgcaaattc taagattgga
    14521 gcaggtacga tagttttaca tgatgtccca gatggaagca cagtggttaa tccagtggaa
    14581 ctaaaagcgc tcgcttcaga agcaaatgtt cagtaataga gaaatgaata gaatattgaa
    14641 aacaatgtta gaggaaagtt atggtaacgc ttgataatac tgaaaatttc attcattttt
    14701 ttaacacatt agggttaatg tttactccac agatttaatt gaattattta ataaaaagat
    14761 taagagacaa gcaaaaaaag attatcttcc tgaatggaga agccgtagat tgttgtctag
    14821 ttccggtgaa tacaaagtaa aatataaaaa ttgcaataac aaagaattcg aattttgttc
    14881 aggtgcttta taaagcctat ttgagtaatt aaatagcaac ttgacactgt gattacataa
    14941 aattattgat aagcctaatt tttatttaat cgtatggatc atttataaaa aatgtataaa
    15001 attgaatata aatgtgaggt gtgattttgg tctataaaca tgggaaaata aaagtgcaaa
    15061 taacaaagaa aggtacccct tttatgaaag gtattattct agcaggtggt tcgggaactc
    15121 gcttgtatcc tttgactcga gccgcatcaa aacaacttat gccggtttat gataaaccga
    15181 tgatttacta cccactttca acattgatgt tggctgggat tagggatatt ttgattattt
    15241 ccactccaca ggatttacat cgatttcaag agcttcttca agacggatct gagtttggga
    15301 tcaaactttc ttatgcagag caaccaagtc cagatggttt ggcacaagcc tttatcattg
    15361 gggaagagtt tatttctgat gatagcgttg cgctaatctt aggtgataat atctaccatg
    15421 gttctgggct ttccaagatg ctacaaaagg cagcgagtaa ggagtcggga gcaactgttt
    15481 ttggctacca tgtcaaggat ccagagcgct ttggtgtggt tgagtttgat caggatatga
    15541 aggctatttc tattgaagaa aagccagagc aacctcgttc aaactatgca gttacaggtc
    15601 tctatttcta tgataatgat gtagtagaga ttgccaaaag tattaaacca agtcctcgtg
    15661 gtgaattgga aattacagac gttaacaagg cttatctaga acgtggtgat ttgtctgttg
    15721 agcttatggg acgtggcttt gcttggttgg atactggcac tcatgaaagt ttactagagg
    15781 cttcgcagta catcgaaaca gtccaacgga tgcaaaatgt tcaggtagca aacttagaag
    15841 aaattgccta tcgcatgggt tatatcagtc gtaaagatgt attgacctta gcccaaccac
    15901 ttaagaaaaa tgaatacgga cagtatctgc tccgtttgat tggagaagca tagatgacag
    15961 ataatttttt cggtaagacg cttgcggcac gcaaggttga agctattcca ggcatgttgg
    16021 agtttgatat ccccgttcat ggagataatc gtggctggtt taaagaaaat ttccaaaagg
    16081 aaaaaatgct tccacttgga tttccagagt ctttctttgc agaaggaaaa ttgcaaaaca
    16141 atgtatcctt ctcacgtaaa aatgtccttc gaggcctcca cgcagagcct tgggataagt
    16201 acatctctgt agcagatgga gggaaagttc tgggttcttg ggttgatcta cgcgagggtg
    16261 aaacctttgg gaatacctat cagacagtaa ttgatgcaag caagggaatc tttgttcctc
    16321 gaggcgtagc taatggcttc caagttctat cagatacagt gtcatatagc tatctggtca
    16381 atgattactg ggctctcgag ctcaaaccca agtatgcctt tgtgaactac gctgatccaa
    16441 gccttggtat tgaatgggaa aatattgcag aagcagaggt ttcagaagca gataaacatc
    16501 atcccctact taaggatgta aaacctttga aaaaagaaga tttgtaaaaa ggaaagaata
    16561 tgactgaata caaaaatatt atcgtgacag gtggagctgg ctttatcggt tctaactttg
    16621 tccattatgt ttacgagaac tttccaggtg ttcacgtgac agtcctagat aagttgactt
    16681 atgctggaaa tcgcgcgaat attgaggaaa ttttaggtaa tcgtgttgag ttagttgttg
    16741 gtgacattgc tgatgcggag ttggtagaca agttggctgc tcaagcagat gctatcgttc
    16801 attatgcagc ggaaagccac aatgataatt cgctcaatga tccatcgcca tttattcata
    16861 ctaacttcat cggaacctat actcttttag aagctgctcg taagtatgat attcgcttcc
    16921 accatgtatc gacagatgaa gtttatgggg atctcccttt acgcgaagat ttgccaggtc
    16981 atggtgaaag accaggtgag aaatttacgg ctgaaacaaa atacaaccca agctctccgt
    17041 actcatcaac caaggcagcc tcagatttga ttgtcaaagc ctgggtgcgt tctttcggag
    17101 tcaaggcaac gatttccaac tgttcaaata actacggtcc ttatcaacat atcgaaaaat
    17161 tcatcccacg tcagattact aacatcctaa gtggtatcaa gccaaaactt tacggtgaag
    17221 gtaagaacgt tcgtgattgg attcatacca atgaccattc ttcaggagtt tggacaatct
    17281 tgacaaaagg gcaaatcggt gaaacctact tgattggggc tgatggtgag aagaacaata
    17341 aggaagtttt ggaacttatc cttaaggaaa tgggacaagc tgcggatgcc tatgatcatg
    17401 tgactgaccg tgcaggacat gaccttcgct atgcgattga tgctagcaag ctccgtgatg
    17461 agttggggtg gaaacctgaa tttaccaact ttgaagctgg gctcaaggca acaatcaagt
    17521 ggtatacaga taaccaagaa tggtggaaag cagaaaaaga agctgttgaa gccaattatg
    17581 ctaagactca ggagattatt acagtataaa aagcaggaaa tagctgcttt ttattgctat
    17641 attgggaaga gttacatatt agaaaggtct agagatgatt ttaattacag gggcaaatgg
    17701 ccaattagga acggaacttc gctatttatt ggatgaacgt aatgaagaat acgtggcagt
    17761 agatgtggct gagatggaca ttaccgatgc agaaatggtt gagaaagttt ttgaagaggt
    17821 gaaaccgact ttagtctacc actgtgcagc ctacaccgct gttgatgcag cagaggatga
    17881 aggaaaagag ttggacttcg ccatcaatgt gacggggaca aaaaatgtcg caaaagcatc
    17941 tgaaaagcat ggtgcaactc tagtttatat ttctacggac tatgtctttg acggtaagaa
    18001 accagttgga caagagtggg aagttgatga ccgaccagat ccacagacag aatatggccg
    18061 tactaagcgt atgggggaag agttagttga gaagcatgtg tctaatttct atattatccg
    18121 tactgcctgg gtatttggaa attatggcaa aaacttcgtt tttaccatgc aaaatcttgc
    18181 gaaaactcat aagactttaa cagttgtaaa tgaccagtac ggtcgtccga cttggactcg
    18241 taccttggct gagttcatga cctacctagc tgaaaatcgt aaggaatttg gttattatca
    18301 tttgtcaaat gatgcgacag aagacacaac atggtatgat tttgcagttg aaattttgaa
    18361 agatacagat gtcgaagtca atccagtaga ttccagtcaa tttccagcca aagctaaacg
    18421 tccgctaaac tcaacgatga gcctggccaa agccaaagct actggatttg ttattccaac
    18481 ttggcaagat gcattgcaag aattttacaa acaagaagtg agataagtag tagaatgatt
    18541 ttctagtcta ataaaagagg cagataatga actccaaagg agcttaagat gtacgattat
    18601 cttgttgttg gtgctggtct ctttggcgca tagctttggc tcagtttcta ttatcgctca
    18661 caccatccat cagaagttta atctgaaggt acccaattat cgccaagaag aagattgggc
    18721 taggaggggt ttaccaatca cacgtaagga aatctctaat tggcatatca aggcaagtca
    18781 atactattta gagtcccttt ataagctttt acgagaaaag ttgttagaac aacctcttct
    18841 tcctgcggat gaaacctctt atcgggttct agagagtgat agccatctga cctactattg
    18901 gacctttttg tctgggaaag ctgagaatca agcaatcacg ctgtaccatc atggtcagtg
    18961 tcgaagtggt ttagtagtac aagaattcct aggagattat tctggctatg tgcattgtga
    19021 tatgttgcgg cagtaactta ggactttagt cctctagttc tgcctatgcg atagcagtcc
    19081 aaggtttagg agcaaggcga cgctaagctt ggtaaactgc gaaccgctag aagcttatcg
    19141 tcaactggaa gaagctgaac ttgttggatg ttgggcacat gtgagaagga agttttttga
    19201 agcgaccccc aagcaagcgg ataaatcatc gttaggagct aaaggtttag cttattgtaa
    19261 tcagttattt tccttggaaa gagactggga ggctttgcca gctgatgaac gactacagaa
    19321 acgtcaagaa gagctccaac ccctaatgga agacttcttt gcttggtgcc gccgtcagtc
    19381 agttttatcg ggttcaaaac taggaagggc aattgaatac agcctcaagt ataaagaaac
    19441 ctttaagact attttgaaag acggacatct ggtcctttcc aataatctag ctgaatgcgc
    19501 cattaaatca ttggttatgg gacggagtaa aagagttcag tggactcttt tagcctaagc
    19561 tcagtttaaa aaagcgaggg tggttatttt ctcaaaattt tgaaggagct aaagcaagag
    19621 ctattattat gagtttgttg gaaacagcta aacgtcatca attaaatagc gagaaatatc
    19681 tattctatct tctagaatgt cttccaaacg aggaaactct cgtaaacaaa gaggttttag
    19741 aggcttattt accatggact aaagttgtac aagaaaagtg caaataagaa atctccagat
    19801 taggaactat ccgtgagttc tctagtctgg agatttttca atatacttcg ttattggacg
    19861 gttacgatat tcatattttt tgcaaagatg ttgtttgaaa aataattttc aaaaattctg
    19921 aaaattctgt tgacaacttt ctgaaaagag tctataatgg agagaaagtt ttaaaggaga
    19981 aaatgatgaa aagttcaaaa ctatttgccc ttgcgggcgt gacattattg gcggcgacta
    20041 ctttagctgc atgctctgga tcaggttcaa gcactaaagg tgagaagaca ttctcataca
    20101 tttatgagac agaccctgat aacctcaact atttg
//
