LOCUS       CR931704               21463 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 1936/39 (serotype 35a).
ACCESSION   CR931704
VERSION     CR931704.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21463)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 21463)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..21463
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="1936/39"
                     /db_xref="taxon:1313"
     gene            <1..163
                     /gene="dexB"
                     /locus_tag="SPC35A_0001"
     CDS             <1..163
                     /gene="dexB"
                     /locus_tag="SPC35A_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI34277.1"
                     /db_xref="GOA:Q4K2R1"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K2R1"
                     /translation="DRRFLVVANLSNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVP
                     WDAFCVELL"
     gene            322..490
                     /gene="aliB"
                     /locus_tag="SPC35A_0002"
                     /pseudo
     CDS             322..490
                     /gene="aliB"
                     /locus_tag="SPC35A_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(508..1008)
                     /gene="tnp"
                     /locus_tag="SPC35A_0003"
                     /pseudo
     CDS             complement(508..1008)
                     /gene="tnp"
                     /locus_tag="SPC35A_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1230..2675
                     /gene="wzg"
                     /locus_tag="SPC35A_0004"
     CDS             1230..2675
                     /gene="wzg"
                     /locus_tag="SPC35A_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI34280.1"
                     /db_xref="GOA:Q4JZF5"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4JZF5"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLLFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYSDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGIDVYNDQ
                     EFTAHTNGKYYPAGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1230..1346
                     /gene="wzg"
                     /locus_tag="SPC35A_0004"
                     /note="Signal peptide predicted for SPC1643 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 39 and 40"
     misc_feature    1434..1781
                     /gene="wzg"
                     /locus_tag="SPC35A_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.3e-62"
     misc_feature    1959..2402
                     /gene="wzg"
                     /locus_tag="SPC35A_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 2.5e-69"
     gene            2677..3408
                     /gene="wzh"
                     /locus_tag="SPC35A_0005"
     CDS             2677..3408
                     /gene="wzh"
                     /locus_tag="SPC35A_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI34281.1"
                     /db_xref="GOA:O86886"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:O86886"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLTESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDRGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHIIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    2680..3288
                     /gene="wzh"
                     /locus_tag="SPC35A_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 4.6e-36"
     gene            3414..4109
                     /gene="wzd"
                     /locus_tag="SPC35A_0006"
     CDS             3414..4109
                     /gene="wzd"
                     /locus_tag="SPC35A_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI34282.1"
                     /db_xref="GOA:O86887"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:O86887"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILIVALVTGAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGSYLVKDYREIILSQDALEKVATNLKL
                     DMPAKTLASKVQVTVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLKI
                     PLLGLVPDFDKIK"
     misc_feature    3414..3530
                     /gene="wzd"
                     /locus_tag="SPC35A_0006"
                     /note="Signal peptide predicted for SPC1645 by SignalP 2.0
                     HMM (Signal peptide probability 0.625) with cleavage site
                     probability 0.411 between residues 39 and 40"
     misc_feature    3435..3851
                     /gene="wzd"
                     /locus_tag="SPC35A_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 3.1e-55"
     misc_feature    3957..4034
                     /gene="wzd"
                     /locus_tag="SPC35A_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4119..4808
                     /gene="wze"
                     /locus_tag="SPC35A_0007"
     CDS             4119..4808
                     /gene="wze"
                     /locus_tag="SPC35A_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI34283.1"
                     /db_xref="GOA:Q4JZK1"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4JZK1"
                     /translation="MPTLEISQAKLDSVKKAEEYYNALCTNLQLSGDGLKVFSITSVK
                     IGEGKSTTSANIAWAFARAGYKTLLIDGDIRNSVMLGVFKARNKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFTTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRNCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGIVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            4823..6190
                     /gene="wchA"
                     /locus_tag="SPC35A_0008"
     CDS             4823..6190
                     /gene="wchA"
                     /locus_tag="SPC35A_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34284.1"
                     /db_xref="GOA:Q4JZF1"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4JZF1"
                     /translation="MNGKILRSSLAIIQSFLVILLTYLLSAVRETEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRRYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHAPLVYVLNLFIKWYWKRAYPNFKGGKKILLLTATSRVEKVLDRLIESNEVVGKL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHIMAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVLM
                     KDGAK"
     misc_feature    4823..4909
                     /gene="wchA"
                     /locus_tag="SPC35A_0008"
                     /note="Signal peptide predicted for SPC1647 by SignalP 2.0
                     HMM (Signal peptide probability 0.844) with cleavage site
                     probability 0.429 between residues 29 and 30"
     misc_feature    5606..6187
                     /gene="wchA"
                     /locus_tag="SPC35A_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 4.8e-158"
     gene            6177..6983
                     /gene="wciB"
                     /locus_tag="SPC35A_0009"
     CDS             6177..6983
                     /gene="wciB"
                     /locus_tag="SPC35A_0009"
                     /note="member of homology group 16"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34285.1"
                     /db_xref="GOA:Q4JZF0"
                     /db_xref="UniProtKB/TrEMBL:Q4JZF0"
                     /translation="MERSRLIDVKIIVATHKEVKMPQDNSLYLPIHVGRDGKSDIGFI
                     GDNTGDNISSLNPYYCELTGLYWAWKNLDYNYLGLVHYRRYFTNKSQGYNENVNMDDV
                     ILSRSNVEILLEKSDVIVPKKRKYYIETLYSHYAHTLNGEHLDLARKIIEQNSSEYLS
                     SFDKVMKQRSGYMFNMFIMKKELLDDYLPWLFSILDTMYEQMDLTDYTSFESRLFGRV
                     SELLFNVWLCKKGITPKEVPFMYMERVDLFEKGKSFLMAKFFGKKYGQSF"
     gene            6992..8185
                     /gene="wzy"
                     /locus_tag="SPC35A_0010"
     CDS             6992..8185
                     /gene="wzy"
                     /locus_tag="SPC35A_0010"
                     /note="member of homology group 45"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI34286.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE9"
                     /translation="MKITIKRYSLPEILGLAALAIFLLFSLLSITLYAQYISIKVYFI
                     ALFGIILLIFLKELISESYNLKSVIGLFVIFTLCFIIGTVTNYAYFFILGLFLIYSLR
                     NLPFSDVAKVSFIISISVLLLVVLSSKLGIIPDYVEIWPTRVRHYLGFRYSLLPSTLM
                     MNIIAISFFLKQENASYPRLLVLFLLSGWLYVETDSRLTFINSCLFLLVNLIMKLSPS
                     IIEKVGRLLKLFSFTYFINACLSYWIAKTYLNTSNVVLNQFFYQVDQFLGGRIYYSNR
                     SLSLYGYKLLGQKIDWIGNGLSIQGERSTETYLYVDNLYIQILQHFGLIVSVIILSLL
                     TITLVKLLKKGQMVLGIILVILSFHALIDDLILNLYYNIFWVLIGMLIYKKYQFYDKK
                     QLTIE"
     misc_feature    6992..7093
                     /gene="wzy"
                     /locus_tag="SPC35A_0010"
                     /note="Signal peptide predicted for SPC1649 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.778 between residues 34 and 35"
     gene            8340..9335
                     /gene="wcrI"
                     /locus_tag="SPC35A_0011"
     CDS             8340..9335
                     /gene="wcrI"
                     /locus_tag="SPC35A_0011"
                     /note="member of homology group 128"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34287.1"
                     /db_xref="GOA:Q4JZE8"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE8"
                     /translation="MNKISLTDNLPLISVVLPVYNVENYLEKCLNSVVRQTYKNIEII
                     IVNDGSLDSSIDICNKYANKDSRIKVFTKPNGGLSDARNFGIKKSMGEFITFVDSDDY
                     VTDDYVEYLYSLVKKYNCKMSMCSIFVHYISNDKMINNGTGRELMMTAEQCIEKMCYH
                     DEVDTCAYAKLYHRSLFSEICFPKGRIFEDIGTIYRFFDTAGQIACGFNAKYYYEIRE
                     NSIVTSSFSEKKFDLLFMTDQMRNFVDQRYPSLKAATKRRAVYARFSTLNQLLDVQGY
                     NEEKKEIIRFIQDNKEALLENPKTPKRDRLAVRALSLGFCIYKLLWKQYLKIQRG"
     misc_feature    8379..8882
                     /gene="wcrI"
                     /locus_tag="SPC35A_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 5.4e-48"
     gene            9337..10479
                     /gene="wcrJ"
                     /locus_tag="SPC35A_0012"
     CDS             9337..10479
                     /gene="wcrJ"
                     /locus_tag="SPC35A_0012"
                     /note="member of homology group 129"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol phosphotransferase"
                     /protein_id="CAI34288.1"
                     /db_xref="GOA:Q4JZE7"
                     /db_xref="InterPro:IPR007554"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE7"
                     /translation="MNKEFLKYIYIRLLRNLRRIFFIIPIIRNRVVFESFSGDAYSCN
                     PKYISEELRKQYGDSVEIIWAFNDPNKFKKELPKEIVTCRYRSFNHLIYRITSKVYIC
                     NFLQAIEIPKRKGQLEIQTWHGGGCYKKVGVAEKGRQAAYVKRQRMHVEETDLFITSS
                     KYFENEVVKKQFGYKGEILSIGMPRNDILINLPISSQVEKLKEKLGLPNNKLIALYAP
                     TWRSGTKQYETLDIKKLTQAVDKKFGKKCIVLFRSHLYGNQSYDDVVDVSQYSDMQEL
                     LLLSDILITDYSSSMWDFSLSFKPCFLYTPDLKDYLDERGFDEDIHSWGFSVSESNKE
                     LVENILQFNNEEYRQKMKNHHQFLESYEQGDAVKRVVAKIAEYCNL"
     misc_feature    9937..10464
                     /gene="wcrJ"
                     /locus_tag="SPC35A_0012"
                     /note="HMMPfam hit to PF04464,
                     CDP-Glycerol:Poly(glycerophosphate) gl, score 1.5e-35"
     gene            order(10492..10611,10636..11399)
                     /gene="wcrK"
                     /locus_tag="SPC35A_0013"
                     /pseudo
     CDS             join(10492..10611,10636..10749,10742..11125,11112..11399)
                     /gene="wcrK"
                     /locus_tag="SPC35A_0013"
                     /note="member of homology group 130"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycosyl transferase"
     misc_feature    join(10540..10611,10636..10742,10749..11112,11125..11381)
                     /gene="wcrK"
                     /locus_tag="SPC35A_0013"
                     /note="HMMPfam hit to PF05704, Capsular polysaccharide
                     synthesis protein, score 1.6e-33"
                     /pseudo
     gene            11419..12135
                     /gene="mnp1"
                     /locus_tag="SPC35A_0014"
     CDS             11419..12135
                     /gene="mnp1"
                     /locus_tag="SPC35A_0014"
                     /note="member of homology group 131"
                     /codon_start=1
                     /transl_table=11
                     /product="putative IspD-family transferase (mannitol)"
                     /protein_id="CAI34290.1"
                     /db_xref="GOA:Q4JZE6"
                     /db_xref="InterPro:IPR001228"
                     /db_xref="InterPro:IPR018294"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE6"
                     /translation="MNLAVIFAGGSGTRMNAKDRPKQFLLVHGKPIIVHTIELFENHP
                     EIDGIIVVCIEDWIPYMEEMKYRYRLDKIAKIVPGGATGQLSIYNGLVAAEQVYGIED
                     NVVLIHDGVRPLITADTISDNIQSVKEKGNAITCTVAKETVILVDDENKVGEVPSREH
                     SRFAKAPQSFWLKDILGAHRDSVDNGRNDFIDSCTMMRHYGHDLHVVVGPYENIKITT
                     PDDFYIFRALYDLRENEQLK"
     misc_feature    11425..12114
                     /gene="mnp1"
                     /locus_tag="SPC35A_0014"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 7e-05"
     misc_feature    11425..12117
                     /gene="mnp1"
                     /locus_tag="SPC35A_0014"
                     /note="HMMPfam hit to PF01128, Uncharacterized protein
                     family UPF000, score 2.4e-23"
     gene            12154..13224
                     /gene="wcrH"
                     /locus_tag="SPC35A_0015"
     CDS             12154..13224
                     /gene="wcrH"
                     /locus_tag="SPC35A_0015"
                     /note="member of homology group 51"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34291.1"
                     /db_xref="GOA:Q4JZE5"
                     /db_xref="InterPro:IPR016503"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE5"
                     /translation="MKYFVEETLLDEQDKKNAGGKARQDVTDILESIGYQKLIAESGM
                     NERQELNAVQRLVHHYKVKKMWKKTLSVVGKGDEVIIQFPLLNHSLFFNQVIKQLSKN
                     GVKVYFLIHDLESLRWSQSKSISLKSRIRLNIEERSVLRLSEGIIAHNKKMKSYIKTY
                     SVESSKIIPLEIFDYIIPSYHERKNLDNFQLNAPIVIAGNLKQHKAGYVYHLPSNVEF
                     NLYGIGYEQTDDKSVHYCGSFMPEELPFVLKGSFGLVWDGPSSESCIETYGEYLRVNN
                     PHKTSLYLASGIPVVVWSEAAIASFIKENNCGILVSNLSELPELLSMITVDEYELMKK
                     NTEIIGERLRQGFYTKQAVKGF"
     gene            13240..14319
                     /gene="mnp2"
                     /locus_tag="SPC35A_0016"
     CDS             13240..14319
                     /gene="mnp2"
                     /locus_tag="SPC35A_0016"
                     /note="member of homology group 132"
                     /codon_start=1
                     /transl_table=11
                     /product="putative dehydratase/epimerase (mannitol)"
                     /protein_id="CAI34292.1"
                     /db_xref="GOA:Q4JZA9"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JZA9"
                     /translation="MIESFNDKVLQEDLEIIAKEELPFRKFRNSTVFITGVTGLVGLQ
                     LFKALACINRVHQLNMKIIGLVRNLDKAEKIFGDLLKRKDIQIVLGDVSEDFHSYIPD
                     GLVIDYIIHGASVTTSKLMIEFPVDTIRVAFNGTYQMLELAKEKKVKSFVYLSSMEVY
                     GSFQSDRTTVVNENMLGYLDLTSVRTNYPECKRICENMCIAFLSQYQVPAKIARLSQT
                     FGAGTLPGENRVFAQFARSVMQGKDIVLHTLGQSEGNYCYTADTVVALLTILLRGENG
                     EAYNIANEESHTTIADMAKMVTSQFSQTSQVVFDIPKKNIFGYAVDTKMKLSTHKIQQ
                     LGWKPRVSLVDAYDRMMRSMNETGV"
     misc_feature    13333..14085
                     /gene="mnp2"
                     /locus_tag="SPC35A_0016"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 9.2e-23"
     misc_feature    13336..14178
                     /gene="mnp2"
                     /locus_tag="SPC35A_0016"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 0.00013"
     gene            14328..15743
                     /gene="wzx"
                     /locus_tag="SPC35A_0017"
     CDS             14328..15743
                     /gene="wzx"
                     /locus_tag="SPC35A_0017"
                     /note="member of homology group 7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI34293.1"
                     /db_xref="GOA:Q4JZA8"
                     /db_xref="InterPro:IPR002528"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4JZA8"
                     /translation="MKVLKNYLYNLSYQLLVIILPIITTPYVTRIFSSDDLGTYGYFN
                     SIVTYFILLATLGIANYGTKEISGNRKSIQKNFWGIYTLQFGATTFSIFLYILACLFI
                     PGMKNLVAYILGLGLVSKGLDISWLFQGLEDFRKITVRNITVKLVGVSAIFLFVKSAS
                     DLYLYVFLLTAFELLGQLSMWFPAREYIGKPHFDIEYARHHLKPVILLFLPQIAISLY
                     VTLDRTMLGALASTKDVGIYDQALKLVNILLTLVTSLGSVMLPRVAHLLATGDHKVVN
                     KMHEVSFLIYNLVIFPIMAGMLIVNDDFVQFFLGQDFQDARYAISIMIFRMFFIGWTN
                     IMGIQILIPHNQNKEFMISTTTPAIISVGLNLLFLPKLGYIGAAIVSVLTEALVWAIQ
                     LFYTRRYLKEVPIIGSMSKIILASAIMYGLLLSSKTVIHFSPTLNVLAFVALGGIIYL
                     FAILSLKVVDVKELKQIIRKN"
     misc_feature    14334..15128
                     /gene="wzx"
                     /locus_tag="SPC35A_0017"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 1.5e-65"
     gene            15745..16743
                     /gene="wciG"
                     /locus_tag="SPC35A_0018"
     CDS             15745..16743
                     /gene="wciG"
                     /locus_tag="SPC35A_0018"
                     /note="member of homology group 21"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase"
                     /protein_id="CAI34294.1"
                     /db_xref="GOA:Q4JZE2"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE2"
                     /translation="MRKNRNINLDLLKVLACVGVVLLHTTMGGFKETGSWNLLAYLYY
                     LGTYSIPLFFMINGYLLLGKREITYLYILPKVKWILITVSSWSFIVWLFKRDFTTNPI
                     KKIVGSLIQRGYFFQFWFFGALILIYLCLPILRQFLNSKRSYLYSLSLLMTIGLIFEL
                     SNILLQMPIQTYVIQTFRLWTWFFYYLLGGYIAQFTIEEIESRFKNWMKIVSILLLLI
                     SPIILFFIAKTIYHNLFAEYFYDTLFVKVSTLGIFLTILMLTLNENRRESIVSLSNQT
                     MGVFIIHTYIMKVWEKVLGFNFVGAYLFFALFTLSVSFIIVGMLMKIPYFNRIVKL"
     gene            16757..17866
                     /gene="glf"
                     /locus_tag="SPC35A_0019"
     CDS             16757..17866
                     /gene="glf"
                     /locus_tag="SPC35A_0019"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI34295.1"
                     /db_xref="GOA:Q4JZE1"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE1"
                     /translation="MYDYLIVGAGLSGAIFAYEATKRGKKVKVIDKRDHIGGNIYCEN
                     VEGVNVHKYGAHIFHTSNKKVWDYVNQFAEFNNYVNSPVANYKGSLYNLPFNMNTFYA
                     MWGTKTPQEVKDKIAEQTADMKDVEPKNLEEQAIKLIGPDIYEKLIKGYTEKQWGRSA
                     TELPPFIIKRLPVRLTFDNNYFNDRYQGIPIGGYNVIIENMLKDVEVELEVDFFAHRE
                     GLEASAEKVVFTGMIDQYFDYKHGELEYRSLRFEHEILDEENYQGNAVVNYTEREIPY
                     TRIIEHKHFEYGTQAKTVITREYPADWKRGDEPYYPINDEKNNAMFAKYQEEASKNDK
                     VIFCGRLADYKYYDMHVVIERALEVVEKEFGYDKK"
     misc_feature    17192..17794
                     /gene="glf"
                     /locus_tag="SPC35A_0019"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 1.1e-136"
     gene            17814..18881
                     /gene="wcjE"
                     /locus_tag="SPC35A_0020"
     CDS             17814..18881
                     /gene="wcjE"
                     /locus_tag="SPC35A_0020"
                     /note="member of homology group 18"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase"
                     /protein_id="CAI34296.1"
                     /db_xref="GOA:Q4JZE0"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:Q4JZE0"
                     /translation="MNGRLRLWRKSLDMTKSRINWIDFGKGFSIFLVLAGHVLLGLYQ
                     SEKFPTANNILSLLIAQVYIFHIPVFFALSGYFFKPVSDLKEFWQYAKKKTIVFGLPY
                     IFYSIIHFGLQKVAGSSVRVPTTISDLLNIYKDPLGVSWYLYILWSILIIYGLLSILV
                     KNRRMLFLISVFAYCLTLFVQTDIYIIQRTLVWGLCFFLGSVLNEIHFDKINLKKFLF
                     FFVLFDFIYMFAWFLFYEVGSKKDYVSYSNPGLWGIAFVVCVLVAFAIFPKMEKNFPK
                     TFLYFTKYGKDSLGIYILHAPICSMIRILMLKVGINSVFLHVVVGIVLGWYLSILATY
                     ILKKIPFLNIVLLPQKYIKLK"
     gene            order(18923..19222,19248..19454)
                     /gene="tnp"
                     /locus_tag="SPC35A_0021"
                     /pseudo
     CDS             join(18923..19222,19248..19454)
                     /gene="tnp"
                     /locus_tag="SPC35A_0021"
                     /note="member of homology group 31"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1671 transposase"
     misc_feature    19263..19448
                     /gene="tnp"
                     /locus_tag="SPC35A_0021"
                     /note="HMMPfam hit to PF05717, IS66 Orf2 like protein,
                     score 4.2e-14"
                     /pseudo
     gene            complement(19676..19861)
                     /gene="tnp"
                     /locus_tag="SPC35A_0022"
                     /pseudo
     CDS             complement(19676..19861)
                     /gene="tnp"
                     /locus_tag="SPC35A_0022"
                     /note="member of homology group 0047 7"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            19946..20924
                     /gene="tnp"
                     /locus_tag="SPC35A_0023"
                     /pseudo
     CDS             join(19946..20677,20688..20924)
                     /gene="tnp"
                     /locus_tag="SPC35A_0023"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     gene            21104..>21463
                     /gene="aliA"
                     /locus_tag="SPC35A_0024"
     CDS             21104..>21463
                     /gene="aliA"
                     /locus_tag="SPC35A_0024"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34300.1"
                     /db_xref="GOA:Q4K2T2"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKD
                     AKWYTSEGEEYAAVKAQD"
     misc_feature    21104..21190
                     /gene="aliA"
                     /locus_tag="SPC35A_0024"
                     /note="Signal peptide predicted for SPC1664 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
     misc_feature    21350..21418
                     /gene="aliA"
                     /locus_tag="SPC35A_0024"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     6845 a   3225 c   4300 g   7093 t
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact tgacagtaga
       61 aggaaaagtc aaatctgtct tgattgaaaa caccctagct caagaagtct ttgaaaaaca
      121 aatcttagtt ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa
      181 atttaaaatt gaaatcgtat aaaaacaagg gaggactgta taaaagacag aaatcctttg
      241 ttttttataa ccaaagttta taaactttca ttctcgaaat tcaattaact ttacaaattc
      301 ccactattaa ggagaaagaa gatgaacata aagaagcgtg tccttagtgc aggcctgact
      361 tttgcatctg ctttgctttt agctgcttgc ggccaatcag gttcagatac aaaaacttac
      421 tcatcaacct ttagtggaaa tccaactaca tttaactatc tattagacta ttacgctgat
      481 aatatagtca attgaaacaa gaacaagaca aaagcagctc aaaaaggtat tgcaacttgg
      541 taataccttt ttgaggtgct ttttgatatg agcccatgtt ttctcaatag gattgtactc
      601 aggtgagtag ggaggaagag gtaaaagttt atacccaaac tcttcacaca agagttctaa
      661 cttacccatt ctatggaatc ttgcattatc cataataata accgatggtg tggttaatgt
      721 tggtaagaaa aacttctgaa accaagcttc aaaaaagtcg ctcgtcatcg tctcttcgta
      781 agtcattgga acgattaatt caccatttgt tagacctgca accaaagaaa tcctctgata
      841 tcttcttcca gatactttgc ctcttcttaa ctgacctttt aatgagcgac catattctcg
      901 atgaaaataa gtatcgaatc ctgtttcatc aatctaaaca ggtgctaggt gctttaaact
      961 attaaaattc ttaagaaata aggctacttt ttctgggtct tgttcataat tagattgaaa
     1021 ctagagtagt acacctctgc ttctaaaaaa atttttagaa atcgatttaa ctgtcctgat
     1081 cgatttgtca tgttcttatt tcattttact atatttttgt ttcgcgggaa gtctactaag
     1141 atacttaaag atgcagatag taaaaaaatg tagacattac cgtaaaaaag tgatataatc
     1201 gtatgatgtt caatgtatag gtgttaatca tgagtagacg ttttaaaaaa tcacgttcac
     1261 agaaagtgaa gcgaagtgtt aatatagttt tgctgactat ttatttattg ttagtttgtt
     1321 ttttattgtt cttaatcttt aagtacaata tccttgcttt tagatatctt aatctagtgg
     1381 taactgcgtt agtcctacta gttgccttgg tagggctact cttgattatc tataaaaaag
     1441 ctgaaaaatt tactattttt ctgttgctgt tctctatcct tgtcagctct gtgtcgctct
     1501 ttgcagtaca gcagtttgtt ggactgacca atcgtttaaa tgcgacttct aattactcag
     1561 aatattcaat cagtgtcgct gttttagcag atagtgagat cgaaaatgtt acgcaactga
     1621 cgagtgtgac agcaccgact gggactgata atgaaaatat tcaaaaacta ctagctgata
     1681 tcaagtcaag tcagaatacc gatttgacgg tcaaccagag ttcgtcttac ttggcagctt
     1741 acaagagttt gattgcaggg gagactaagg ccattgtcct aaatagtgtc tttgaaaata
     1801 tcatcgagtc agagtattca gactacgcat cgaagataaa aaagatttat accaagggat
     1861 tcactaaaaa agtagaagct cctaagacgt ctaagaatca gtctttcaat atctatgtta
     1921 gtggaattga cacctatggc cctattagtt cagtgtcgcg atcagatgtc aatatcctga
     1981 tgactgtcaa tcgagatacc aagaaaatcc tcttgaccac aacgccacgt gatgcctatg
     2041 taccaatcgc agatggtgga aataatcaaa aagataaatt aacccatgcg ggcatttatg
     2101 gagttgattc gtccattcac accttagaaa atctctatgg agtggatatc aattactatg
     2161 tgcgattgaa cttcacttcg tttttgaaat tgattgattt gttgggtgga attgatgttt
     2221 ataatgatca agaatttact gcccatacga atggaaagta ttaccctgca ggcaatgttc
     2281 atcttgattc agaacaggct ctcggttttg ttcgtgagcg ctactcacta gcagatggcg
     2341 atcgtgaccg cgggcgcaat caacaaaagg tgattgtggc tatccttcaa aaattaacgt
     2401 caaccgaagc actgaaaaat tatagcacga tcattaatag cttgcaagat tctatccaaa
     2461 caaatatgcc acttgagact atgataaatt tggtcaatgc tcagttagaa agtggaggga
     2521 attataaagt aaattctcaa gatttaaaag gtacaggtcg gacggatctt ccttcttatg
     2581 caatgccaga cagtaacctc tatgtgatgg aaatagatga tagtagttta gctgtagtta
     2641 aagcagctat acaggatgtg atggagggta gatgaaatga tagacatcca ttcgcatatc
     2701 gtttttgatg tagatgacgg tcccaagtca agagaggaaa gcaaggctct cttgacagaa
     2761 tcctacaggc agggggtgag aaccattgtc tctacctctc accgtcgcaa gggcatgttt
     2821 gaaactccgg aagagaagat agcagaaaac tttcttcagg ttcgggaaat agctaaggaa
     2881 gtggcgagtg acttggtcat tgcttatggg gctgaaattt actacacacc agatgttctg
     2941 gataagctgg aaaaaaagcg gattccgacc ctcaatgata gtcgttatgc cttgatagag
     3001 ttcagtatga acactcctta tcgcgatatt catagcgcct tgagcaagat cttgatgttg
     3061 ggaattactc cagtcattgc ccacattgag cgctatgatg ctcttgaaaa taatgaaaaa
     3121 cgcgttcgag aactgattga taggggctgt tacacgcaag taaatagttc acatgtcctc
     3181 aaacccaaac tttttggcga acgttataaa ttcatgaaaa aaagagctca gtatttttta
     3241 gagcaggatt tggttcatat cattgcaagt gatatgcaca atctagacgg tagacctcct
     3301 catatggcag aagcatatga ccttgttacc caaaaatacg gagaagcgaa ggctcaggaa
     3361 ctttttatag acaatcctcg aaaaattgta atggatcaac taatttagga gaaatgatga
     3421 aagaacaaaa cacgatagaa atcgatgtat ttcaattatt taaaaccttg tggaaacgca
     3481 agctaatgat tttaatagtg gcacttgtga caggtgcggg ggcttttgca tatagcactt
     3541 ttattgttaa gccagaatat acgagtacca cgcgaattta cgtagtgaat cgcaatcaag
     3601 gagacaagcc ggggctgaca aatcaggatt tgcaggcagg atcttatctg gtaaaagact
     3661 accgtgagat tatcctttcg caggatgcat tggaaaaagt agcgacaaat ttgaagttgg
     3721 atatgccagc aaaaacgtta gccagcaaag ttcaagtgac tgtaccagct gacactcgta
     3781 tcgtctcaat ctctgtcaag gataaacagc cagaggaagc cagtcgtatc gctaattctc
     3841 tacgagaagt tgctgcagaa aagatcgtcg ctgtaacgcg agtatctgat gtaacgacac
     3901 ttgaagaagc gcgaccagct acgactccct cttctccaaa tgttcgacgc aattccttgt
     3961 ttggttttct tggaggagca gtcgtaacag taattgctgt tcttttgatt gagttgctgg
     4021 acacccgtgt gaaacgtcct gaagatgttg aagatgtact gaaaattcca cttttagggc
     4081 tcgttccaga ttttgacaaa ataaaatagg aggaagttat gccaacatta gaaatctcac
     4141 aggcaaaatt ggattctgta aaaaaggcag aggaatatta taacgctttg tgcacgaacc
     4201 tacagttaag tggagatggt ttgaaagtat tttctatcac ttctgtgaaa ataggagaag
     4261 gaaaatcaac gacttccgcc aatatcgctt gggcttttgc gcgtgcaggt tacaaaacgc
     4321 tgctgattga tggagatatt cgcaattctg ttatgttagg tgtctttaaa gcaaggaata
     4381 agattacagg cctgacagaa tttttatcag gaactacaga cttatcacaa gggctttgtg
     4441 ataccaatat cgaaaatctc tttgtaattc aggctggctc tgtgtcaccg aatccgacag
     4501 ctcttcttca aagtaagaat ttcactacaa tgcttgaaac cttgcgtaaa tattttgact
     4561 acatcattgt agatactgct cctgttggtg tcgtgattga tgcggctatt attacgcgaa
     4621 actgcgatgc ttctatttta gtgacggagg caggtgaaat aaatcgtcgg gatattcaaa
     4681 aagcaaaaga acagttggaa cacacaggaa agccgttttt gggaattgtg ttgaataaat
     4741 tcgatacttc agtagacaaa tacggttctt atggaaatta tggagattac gggaaaaata
     4801 aaaaataggt cgggggatag agatgaatgg aaaaatatta aggtcttcat tggccataat
     4861 ccagagtttt cttgttattt tattgactta tctacttagt gctgtgagag aaacggagat
     4921 tgtttcaaca acagctattg cactttatat cctccattat tttgtctttt atatcagtga
     4981 ttatggacag gatttcttta aaaggagata tttgattgaa cttgtccaga cattgaaata
     5041 tatcctattc tttgcactag cgattagtat ttctaatttt ttcttagagg atcgatttag
     5101 tatttccaga cgaggcatga tttacttcct cacattacat gctcccttag tctatgtgct
     5161 aaacctattt atcaagtggt attggaagcg ggcttatccc aactttaaag gaggtaagaa
     5221 gattctccta cttacagcaa cttctcgtgt cgaaaaggta ctggatagat taatagaatc
     5281 aaatgaggtt gttgggaagt tggtagccgt cagtgtctta gataaaccag attttcagca
     5341 tgattgttta aaggtagtag cagaggggga gatagtaaac tttgcgactc atgaggtggt
     5401 cgatgaagtc tttatcaatc ttccaagtga aaaatacaat attggagagc ttgtctctca
     5461 gtttgaaacg atgggaattg atgtaacagt taatctaaat gcttttgatc gtagtttggc
     5521 acgtaacaag caaattcgtg agatggcagg attaaacgtt gtgacttttt ctacaacatt
     5581 ttataagact agtcatataa tggctaagcg gattattgat attatgggtg cattggtagg
     5641 gctgatacta tgtggtttag tcagtattgt actggttcct ttgattcgaa aggatggggg
     5701 ttctgctatt tttgctcaga cgcgtatagg aaaaaatggt cgtcagttca ctttttataa
     5761 gtttcgctct atgtgtgtag atgccgaggc gaaaaaaaga gaactcatgg aacaaaatac
     5821 catgcagggt ggaatgttta aggtggacga tgatcctcgt atcacgaaaa ttggtcgttt
     5881 tatacggaag actagcttgg acgagctacc acagttttat aatgttctaa agggagatat
     5941 gagtttggtt ggcacacggc caccaacagt ggacgagtat gaacactata ccccagaaca
     6001 aaaacgtcgg ctaagtttta aacctggtat aacaggctta tggcaggtca gtggacgaag
     6061 tgagattaag aattttgatg aagttgtcaa attagatgta gcctatatag acgattggac
     6121 aatttggaaa gatattgaga ttttattgaa gacagttaaa gttgtattga tgaaggatgg
     6181 agcgaagtag attgatagat gtaaaaatca ttgtggcaac acataaagag gttaaaatgc
     6241 ctcaagacaa tagtctttac cttccaatac atgttgggag agacggtaaa tcagatattg
     6301 gttttatcgg tgataatact ggcgataata tatcctctct aaatccatat tattgtgagt
     6361 tgacgggact ttattgggca tggaagaatc ttgattataa ttacttaggt ctagttcatt
     6421 accgtcgtta ttttacaaat aaatctcaag ggtataatga aaatgtcaat atggatgacg
     6481 tcattttgtc tcgatctaat gttgaaatat tattagagaa atctgacgta atagttccaa
     6541 agaagcgaaa gtattatatt gaaactcttt attcacatta tgcccatacc cttaacggag
     6601 aacatctgga tcttgctagg aaaattattg agcaaaatag ttcagagtat ctttcatcct
     6661 ttgataaagt gatgaaacaa agaagcggtt atatgttcaa tatgtttatc atgaaaaaag
     6721 aactattaga tgattattta ccgtggcttt tttctattct ggatactatg tacgaacaga
     6781 tggacttgac cgactatact tcatttgagt cacgtttatt cgggcgagtt agtgagttgt
     6841 tgtttaatgt ttggttatgt aaaaaaggaa taacgcctaa agaggtacca tttatgtaca
     6901 tggagagagt ggatttgttt gaaaaaggaa aatctttttt aatggctaaa ttttttggaa
     6961 agaagtatgg acagagtttc taggagggaa tatgaaaatc accatcaaaa ggtattcact
     7021 gccagaaatt ttaggactag cagcattagc tatattccta ctattttcgt tattaagtat
     7081 aactctttat gcccaatata tatctattaa agtatatttt attgcacttt ttggcattat
     7141 tttattaata tttctgaagg aacttatatc tgagagttat aatcttaaat ctgtgattgg
     7201 attattcgtg atttttactc tctgcttcat cataggtacc gtcacaaatt acgcatactt
     7261 ttttatttta ggtctgtttt tgatttatag tcttagaaat ctcccttttt cagacgtagc
     7321 caaagtctcc tttatcatta gtattagtgt attgctccta gtagtattga gtagtaagct
     7381 tggtattatt cctgattatg ttgagatttg gcctaccaga gttagacact atcttggttt
     7441 ccgatattca ttacttccat caacgcttat gatgaatatc atagctatat catttttttt
     7501 aaagcaagaa aatgcttcat atccgcgtct tcttgtattg tttttacttt caggatggtt
     7561 atacgtagaa acagattcac gtttgacttt tattaattcg tgtttgtttc tactggttaa
     7621 tttaataatg aaattgtcac cttccatcat tgaaaaggta gggagactat taaaactttt
     7681 ttcgttcacc tactttatta atgcctgttt gagttactgg attgcgaaga cttacttaaa
     7741 cacctcaaat gttgttttga atcaattctt ttaccaagtg gatcaatttc ttggaggacg
     7801 tatttattat tctaatcgtt cgttatcttt atatggatat aagttgttag gtcaaaagat
     7861 tgattggatt ggaaatggct tgagcataca aggggagcgt agcacagaaa catatttgta
     7921 tgtggataat ttatatatcc agattcttca acattttggt ttgatagttt cggtaattat
     7981 tttaagccta ttaactataa ctttagtaaa gcttttgaaa aaggggcaga tggtattagg
     8041 aattatttta gttattttga gttttcatgc tttaattgat gatttgatac taaatctata
     8101 ttataatata ttttgggttt tgataggaat gttgatatat aaaaagtatc aattttatga
     8161 caaaaagcag ttgacaatag aataagaagc aagcattgga aatagacatt cagatatgta
     8221 caagaaaact cgatttaagt tttttggtaa aatttttaaa attaagttgt aaaatggata
     8281 tcaaaatctc accttttttt gtaggtgtga ttaaacagag ggatttagat aggaaaataa
     8341 tgaataagat tagcttaact gataatttac cgttaatttc agttgtttta ccagtataca
     8401 acgtagagaa ttatttagaa aaatgtttga attctgttgt gagacagacg tataaaaaca
     8461 tagaaattat aatagtaaat gatggtagct tagattcttc aatagatatt tgtaataagt
     8521 atgcaaataa agatagtcga attaaagtat ttacaaaacc taatggaggt ttgtctgatg
     8581 ctagaaattt cggtatcaaa aaatctatgg gtgagtttat aacattcgtt gattcagatg
     8641 actatgttac agatgattat gtagaatatt tgtatagctt agtcaaaaaa tataattgta
     8701 aaatgtcaat gtgttcaata tttgtccatt atatttctaa tgataaaatg atcaataatg
     8761 ggacaggaag agaattgatg atgacagcag agcagtgtat tgaaaaaatg tgctatcatg
     8821 atgaggtgga tacatgtgct tatgcaaaat tatatcatag aagtctattt agtgaaatat
     8881 gcttccctaa aggaaggata ttcgaagata ttggaacaat ttatcgcttt tttgatactg
     8941 ctgggcagat tgcctgtggt tttaacgcaa aatattatta tgagattcgg gaaaattcga
     9001 ttgttacatc atcatttagt gaaaaaaaat ttgatttgtt atttatgaca gatcaaatgc
     9061 gaaattttgt tgatcaacgc tatccatctt tgaaagctgc aacaaaacgt cgagctgtct
     9121 atgcaagatt tagtaccctt aaccaattat tggatgtaca aggatataat gaagaaaaaa
     9181 aagaaataat tcgttttatc caagacaaca aggaagcgtt acttgaaaat cctaagactc
     9241 ctaagcggga tagattagct gttagagctc tctcccttgg attttgcatt tataaattgt
     9301 tatggaagca atatttaaaa attcaaagag gttagtatga ataaagaatt tttgaagtat
     9361 atttatattc gattattaag aaatttaagg agaattttct ttattatccc gataataaga
     9421 aatagagttg tttttgaatc tttctcagga gatgcttata gttgcaatcc taaatatatt
     9481 tctgaagaat taagaaaaca gtatggtgat tctgttgaaa ttatctgggc ttttaatgat
     9541 ccaaacaaat tcaaaaaaga attaccaaag gagattgtga cttgtcgtta ccgtagtttc
     9601 aatcatctga tatatagaat cacttcaaaa gtttatattt gtaatttcct gcaagcaatc
     9661 gaaattccaa agcgtaaagg acaactagag attcaaactt ggcatggagg aggttgctat
     9721 aaaaaagttg gggtggctga aaaaggacgc caggctgctt atgttaaacg acaacggatg
     9781 cacgttgaag aaacagatct ctttattaca agtagtaaat attttgaaaa tgaggtagta
     9841 aaaaaacaat ttgggtataa gggagaaatt ttatctattg gtatgcctcg aaatgatatt
     9901 ttaataaatt taccaatttc aagtcaagtt gagaaattaa aggagaaatt gggattacca
     9961 aacaataaat tgatagcact ttatgctccg acctggagat caggtactaa acagtatgaa
    10021 acacttgata taaaaaaact tactcaagcc gttgataaaa aatttggtaa aaaatgtatt
    10081 gttcttttca gatcgcatct atatggaaat caatcttatg atgatgttgt ggatgtctct
    10141 cagtatagtg atatgcaaga attattgttg ctttcagata tactgattac tgactattct
    10201 tcgtctatgt gggatttctc tctctctttt aaaccgtgtt ttttatatac ccccgatttg
    10261 aaggattatc tagatgaaag aggttttgat gaagacatac attcatgggg attttcagtt
    10321 tctgaatcaa ataaggaact agttgaaaat attttacagt ttaataatga agaatataga
    10381 caaaaaatga agaatcatca tcagttttta gaatcttatg aacaaggaga tgcagtgaaa
    10441 agagttgtgg cgaagattgc tgaatattgt aatttataga gaggatagat aatgaaaaaa
    10501 attggtgatt tggtcaaaag atatggtgtg aaaaatgtgg ttttacgtgc tattaatgat
    10561 gttctaccag tcaatctcat ctttcctagt caacaactca gacgtttgaa ttgacaagaa
    10621 aaagtcaaaa agaagttgaa aaaatatgta gttgtttcgg attcaatcaa gagtgaggag
    10681 gagtgcgata ttatctggtg gctatggttt caaggacttg ataatgcact agctattgtg
    10741 aaaaaaatgt agagagtcgg tagataaata tgctaaacgc agtggcaaaa gggttattga
    10801 gttaacatct caaaatttat ttgaatatat tgaggtacct aacgaactct atgtaaaata
    10861 taagtcaggt agtttgccat tagctttgtt ttcagatttt tgtcgaatta gccttctttc
    10921 taactatgga ggattatggg ttgattcaac tgttctaatt acggggaaaa ttgaagatga
    10981 gatattgaac caagatattt ttatgtttca agcttcccct ttagactatt cggttactaa
    11041 aatcagtaat tggatgttat attcaaaata cccaggacac ccgttcatat tatcgatacg
    11101 tgatactttg atttcatttt ataaataata agaataatac gattccggat tgttttttat
    11161 ttcatttact tgtttcctgt ttaatagatg ataataggat aaatcaaagt ttttataata
    11221 tggattatta tactaatacc tatcctcact tattagggag agttttgagc gaaccatatg
    11281 atcctttgaa atttgaaaat attttaagga aaacgtctat ttataaatta tcatataaaa
    11341 atttaaatta tgttgctgag gatagatttt ataatgcaat tttagattta gattttagtt
    11401 agaataaaga ggagagaaat gaatttagca gttatttttg ctggaggatc cggtacgcga
    11461 atgaatgcaa aggatagacc taagcagttt cttttggtac atggtaagcc aattattgtt
    11521 cacactattg agctatttga gaaccatcca gagattgatg gaattatcgt tgtttgtatt
    11581 gaggattgga ttccgtatat ggaggagatg aaatatcgct atagattaga taagattgct
    11641 aagattgttc cagggggggc aactggtcaa ttatctattt ataatggttt agtcgcggct
    11701 gaacaagttt atggaataga ggataatgtt gtgttaatcc atgatggagt ccgtccttta
    11761 attacagcag acactatttc agataacatc caatccgtaa aagaaaaggg aaatgctatt
    11821 acttgtacag tggccaaaga aacagttatc ttagtagatg atgaaaataa ggtaggcgaa
    11881 gtgcctagtc gtgaacattc gcgatttgcc aaggctcctc agagtttttg gctaaaagat
    11941 attctaggtg cacatcgaga ctctgtagat aacggtagaa atgattttat tgattcatgc
    12001 accatgatga gacactatgg tcatgattta catgttgttg ttggtccgta tgagaatatt
    12061 aagattacaa cgcctgatga tttttatata tttagggctt tgtacgatct tcgtgagaat
    12121 gagcaactaa aataatgaag aaaagagaaa aagatgaagt attttgttga agaaacgtta
    12181 cttgatgaac aggataaaaa aaatgcgggt ggaaaggcta gacaagacgt cactgatatt
    12241 ttggaatcca taggttatca gaagttaata gctgagtccg gaatgaatga acgtcaggaa
    12301 ttaaatgctg ttcaaagatt ggttcatcat tataaagtta agaaaatgtg gaagaaaact
    12361 ctttcagttg ttggtaaggg tgatgaagtt attattcaat ttcctttact aaatcatagt
    12421 ttattcttta atcaggttat taagcaactt agtaagaatg gagttaaagt ttattttttg
    12481 attcatgatt tagaatcgtt gcgatggtcg cagtcaaaat cgatatcatt aaaaagtagg
    12541 attcgattaa acattgaaga acgtagtgtt ttaaggttat cagaaggcat tattgctcat
    12601 aataaaaaaa tgaaatctta tattaagacc tactctgttg aaagttctaa aattattcct
    12661 cttgaaattt ttgattatat tattccatct tatcatgaaa gaaaaaatct ggataacttt
    12721 cagttaaatg ctccaattgt tattgctgga aatttaaagc aacataaagc tggatatgtc
    12781 tatcatttac caagcaatgt ggagtttaat ctttatggaa ttggatatga acagacagat
    12841 gacaaaagtg tgcactactg tggttctttt atgccagaag aattaccatt cgttttaaaa
    12901 ggaagttttg gattggtatg ggatggtccg tcatcagagt cttgtataga aacttatgga
    12961 gagtatcttc gtgtaaacaa ccctcacaag acttcactat atttagcttc aggcatacca
    13021 gtagttgtat ggtcagaggc agcaatagct agtttcatta aggagaataa ttgtggtatt
    13081 cttgtatcca atctgagtga actacctgag ttactttcta tgattaccgt tgatgaatat
    13141 gaattgatga aaaagaatac tgagattatt ggagaaaggc ttcgacaagg tttttatact
    13201 aaacaagcag ttaaaggttt ctagactgga ggaagtgtaa tgattgaaag ttttaatgat
    13261 aaagtgttgc aggaagattt agagataatt gcaaaagaag agcttccatt tcgaaaattt
    13321 agaaattcaa ctgtttttat cacgggagta acaggtttag taggccttca attatttaag
    13381 gctttggctt gtatcaatag agtccatcag ttgaatatga aaattattgg tctagtcaga
    13441 aatttggata aagcagaaaa aatttttgga gatttattga aacggaagga tatacaaata
    13501 gttttaggag atgtttcgga agatttccac tcgtatatcc ctgatggttt agttattgac
    13561 tatatcattc acggagcaag cgtgactacc tctaaactca tgattgaatt tccagtagat
    13621 acaattcgag tagcttttaa tggaacgtat caaatgttag aattggcaaa agaaaaaaaa
    13681 gtgaaaagtt ttgtatatct ttcttcaatg gaggtatatg gtagctttca gtcagataga
    13741 acaactgttg taaacgagaa tatgttaggg tatcttgatt tgacatctgt tcgaacaaat
    13801 tacccagaat gcaaaagaat ttgtgaaaat atgtgcattg catttctaag tcagtatcaa
    13861 gtcccggcta agattgctcg tctatcccag acctttggtg caggcactct accgggtgaa
    13921 aatagagtat ttgctcaatt tgctcgtagt gttatgcaag ggaaagatat tgttttacat
    13981 acgttagggc aatcagaagg aaattactgc tacacagctg atactgttgt tgcattatta
    14041 acaattctat tgagaggaga aaatggggag gcttataata ttgctaatga agagagtcat
    14101 acaacaatag cagatatggc aaaaatggta acttcgcaat tctctcaaac gagtcaagtg
    14161 gtttttgata ttccgaagaa aaatatattt ggttatgctg tagatactaa aatgaagtta
    14221 tcaacacaca aaattcaaca attgggttgg aagccgaggg tctctcttgt agatgcttat
    14281 gatcgaatga tgagaagtat gaatgaaact ggggtatagg taactatatg aaggtattaa
    14341 aaaactactt atataatctc tcttatcaac tattagttat tattcttcct atcattacga
    14401 ctccttatgt gacgcgcata ttttcttcag atgatttagg gacatacggt tacttcaact
    14461 ccattgttac ctacttcatt ttacttgcta ctctgggtat tgctaactat ggaacgaagg
    14521 agatatctgg gaataggaag agtattcaga aaaatttctg gggaatatat actttacagt
    14581 ttggagcgac tactttttcc atttttctct atatactagc ctgtcttttc atcccaggga
    14641 tgaaaaacct agttgcatat atcttgggat tgggtttagt ctctaaagga ctagatattt
    14701 catggttgtt tcaagggtta gaagattttc gtaaaattac ggtcagaaat atcacagtga
    14761 agcttgttgg tgtaagtgcc attttcttgt ttgtaaaatc agcgagtgat ctatacttgt
    14821 atgtttttct tctaacagca tttgaattgt tgggtcagtt aagtatgtgg tttccagccc
    14881 gtgaatatat tggaaaacca cattttgata tagaatatgc taggcatcat ctgaagccag
    14941 ttatcttgct attcttacca caaattgcta tctcgcttta tgtgacttta gatcgtacaa
    15001 tgttaggggc gctagcttct acaaaagatg tcggcattta tgatcaggct ttgaagctgg
    15061 ttaatatttt actgaccttg gtaacttcct tgggaagtgt tatgctgcca cgcgttgcgc
    15121 atttgttagc gacaggtgat cataaggtag tcaataagat gcatgaggta tccttcttaa
    15181 tttataattt ggttattttt ccgattatgg cagggatgtt gattgtgaat gatgattttg
    15241 ttcaattttt ccttgggcaa gactttcaag atgcacgcta tgcaatttcc attatgatct
    15301 tccgtatgtt ctttatcggt tggactaata taatgggaat tcagatactg atacctcata
    15361 atcaaaataa agaattcatg atttcaacaa caactcccgc aattatcagt gtaggtttga
    15421 acttactatt ccttcctaaa ctgggatata tcggggcagc cattgtctct gttttaacag
    15481 aggcacttgt atgggcaatc caattattct atactcgcag atatttaaaa gaagttccta
    15541 taatcggatc aatgtcaaaa attatactag catctgccat tatgtatggc cttttactaa
    15601 gttcaaaaac agttatacat ttttcaccga ccttaaatgt gctagcattt gtagcgcttg
    15661 gtggaatcat ttatcttttt gcaattctat ctctgaaagt ggtagatgtg aaagaattaa
    15721 aacaaattat taggaaaaac tagaatgaga aaaaatcgaa atatcaacct agatttacta
    15781 aaagtgcttg catgtgttgg agttgtttta cttcatacaa caatgggcgg atttaaagag
    15841 acaggttcat ggaatctttt ggcatattta tattatttag gtacttactc tattcccttg
    15901 ttttttatga tcaatggtta tttgttgtta ggcaagaggg agataactta tctttacata
    15961 ctcccgaaag taaaatggat tttaataaca gtgtcatcat ggtcatttat cgtatggctt
    16021 tttaagcgtg attttacaac taatcctatt aaaaaaattg taggttcttt gatacaaaga
    16081 ggttatttct ttcagttttg gtttttcggt gcactcatac ttatctattt atgtttgcca
    16141 attttgagac aatttctaaa ttcaaaaaga agctatttat acagtttatc tttattgatg
    16201 actattggtt tgatttttga gttatcaaat atcctacttc aaatgccaat acaaacatat
    16261 gtaatacaaa cttttagatt atggacgtgg tttttttact atcttttagg tggttatata
    16321 gcgcaattca ctatagaaga aatcgaatca aggtttaaga attggatgaa aatagttagc
    16381 atacttttgt tattgatttc accaataata ttatttttca tagcgaagac tatataccat
    16441 aatctatttg ctgaatactt ttatgatact ttatttgtaa aagtcagtac tttaggaatt
    16501 tttctaacta tcctcatgct tactttgaat gaaaaccgaa gagaatcgat tgtttccctt
    16561 tctaatcaaa caatgggggt tttcataata catacttata ttatgaaagt gtgggaaaaa
    16621 gtgcttggtt ttaattttgt aggagcatat ttattttttg ctctatttac tttaagtgtt
    16681 agttttatta ttgttgggat gttaatgaag attccttact tcaatcgaat cgtcaaatta
    16741 taaaaaggag aacaagatgt acgattatct tattgtcggt gctggtttgt caggagcaat
    16801 ttttgcttat gaggcgacca agcgtggaaa aaaagtaaaa gtgattgata aacgtgacca
    16861 cattggtggg aatatctact gtgagaatgt agaaggagtt aatgttcaca aatatggtgc
    16921 ccatatcttt catacttcta ataagaaagt ttgggattat gttaatcaat ttgctgaatt
    16981 taacaactac gtcaactcgc ctgtagctaa ttacaagggt agcctctata atctaccttt
    17041 caatatgaat accttctatg ctatgtgggg gacaaaaact cctcaagaag tcaaagataa
    17101 gattgctgag cagacagctg atatgaagga tgttgagccg aaaaatctgg aagaacaagc
    17161 tatcaagctg attggtccag atatctacga aaaattgatc aagggttata ctgaaaagca
    17221 gtgggggcgc tcagcaacag aacttcctcc atttatcatt aaacgacttc cagttcgtct
    17281 aacatttgat aataactatt ttaatgaccg ttatcaagga attcctattg gtggttataa
    17341 tgtgattatt gaaaatatgc ttaaagacgt agaagttgaa cttgaagtag atttctttgc
    17401 tcaccgtgaa gggttggaag catctgctga aaaagttgtc ttcacaggaa tgatcgacca
    17461 atattttgac tacaaacacg gagagttaga ataccgtagc cttcgttttg agcatgagat
    17521 tttagacgag gaaaattatc aaggaaatgc tgtagtgaac tatacggagc gtgagattcc
    17581 ttatactcgt attatcgaac acaagcattt tgaatatgga acgcaggcaa agacagttat
    17641 cacgcgtgaa tatccagctg actggaagcg tggggacgag ccttactatc cgatcaacga
    17701 tgagaaaaat aatgctatgt ttgctaagta ccaagaggaa gcttcaaaga atgataaggt
    17761 tattttctgt ggacgtttag cagattataa atattatgat atgcatgtgg tgattgaacg
    17821 ggcgcttgag gttgtggaga aagagtttgg atatgacaaa aagtagaatc aattggatag
    17881 attttggaaa aggcttttcc atatttttag tcttagcagg gcatgtgttg cttggactgt
    17941 atcaatcgga aaaatttccc acagcaaata acatactatc gttgttgata gcacaagtct
    18001 acatatttca tataccagta ttttttgcct tatcaggata ctttttcaaa cctgtgtcgg
    18061 atttgaagga gttctggcaa tatgctaaaa agaagacaat tgtttttggt ctgccatata
    18121 ttttctattc gatcattcac tttggtcttc aaaaagttgc agggtcatct gttcgtgttc
    18181 ctacaaccat atctgatttg ctaaatatct ataaagatcc tcttggagtt tcgtggtatt
    18241 tatatatact ctggtcgatt ttgataatct atggattatt gtctatttta gtcaaaaatc
    18301 gtagaatgtt atttttgata agtgttttcg cttattgttt aaccctattt gttcaaacag
    18361 atatttatat tattcaaaga acgctagttt gggggctttg tttctttctt ggcagtgtat
    18421 tgaatgaaat tcactttgat aaaattaatt tgaaaaaatt tctttttttc tttgtgctat
    18481 ttgattttat ttatatgttc gcttggttct tgttttatga agtagggtct aagaaggatt
    18541 atgtaagcta tagtaaccca ggtttgtggg ggattgcttt tgttgtctgt gtattagttg
    18601 cttttgcgat ttttccgaaa atggagaaaa attttcctaa aactttccta tatttcacta
    18661 aatacgggaa agatagttta gggatttata ttcttcatgc accaatttgt agcatgattc
    18721 ggattctaat gttgaaagtg ggaataaact cagtttttct tcacgttgtt gttgggattg
    18781 tgctaggctg gtatttatcc atactagcaa cttatatatt gaaaaaaatt ccatttttga
    18841 atattgtttt attaccacaa aagtatatta aattaaaatg actctttgtc aactgtagtg
    18901 ggttgaagaa aagctaagct cgagaaagga caaattttgt cctttctttt ttgatattca
    18961 gggcgataaa aatccgtttt ttgaagtttt caaaggtaag cgcgtcataa caaggtatct
    19021 atcattcatg gaagacctcc tgtatactat tagtaaagta aaactattgg aggatattgt
    19081 aatgccacaa cctattgttc ctgtagagat tccacaatct cgtcgttttg attctaaaaa
    19141 gagaaatgat attctgctta aaattcgtat tggcaagctt gaagtaagtt tttttcaatc
    19201 tctcaatctc gaaatgatat aacagctttt ggataaggtg ttgctttatg acaattcatc
    19261 tatctagcct agggcaggtc tatctcgtat gtgggaaaac ggatatgagg caaggcattg
    19321 attcactggc ttatctggtt aaaacccgct ttgaattgga tcctttctca ggtcaagttt
    19381 ttctcttttg tggtggacgt aaagaccgct ttaaagccct ttactgggat ggtcaaggat
    19441 tttggctatt atagtggatt taaactagaa tagtacacct ctgcttctaa aacattgtta
    19501 gaaatcgatt tgactgtcct gttcttattt cattttacta taaattcatc agaaagtcgt
    19561 gatttctatt gaaatgagga ctttcttttt atactcatct gctttcaaaa agcattctag
    19621 tccatctccg attaacgatg gactttatca cctccttctc cagtccttgt atgacatctt
    19681 ggagttgatt catgacatct tccaaagttc gaaaggcctt attcttaaat ccacgtttac
    19741 gaatctcttt ccacacttgt tcaatggggt tcatctctgg tgtgtatgga agaataaagg
    19801 taaaaccaat attagtcgga atctttaagg tacttgattt ataccatata gcattgtcca
    19861 taacgagtaa aagataatca tctggataag cttgtgaaag ctcctattcc taaagcccct
    19921 ttataacctc ttgcgagaga gactattgac tcagccctta cttcatgcgg atgaaacctc
    19981 ctatcgggtt ctagagaatg atagccatct gacctactat tggacctttt tgtctgggaa
    20041 agctgagaat caagcaatca cgctgtacca ccatgatcag cgtcggagtg gttcggtagt
    20101 gcaagaattc ctaggagatt attctggcta tgttcattgt gatatgttgc ggcagtaact
    20161 taggacttta gtcctctagt tctgcctatg cgatagcagt ccaaggttta ggagcaaggc
    20221 gacgctaagc ttggtaaact gcgaaccgct agaagcttat cgtcaactgg aagaagctga
    20281 acttgttgga tgttgggcgc atgtgagaag gaagtttttt gaagcgcccc gcaagcaagc
    20341 ggataaatca tcgttaggag ctaaaggttt agcttattgt gatcagttat tttccttgga
    20401 aagagactgg gaggctttac cagctgatga acgactacgg aaacgtcaag aacatctcca
    20461 gcccctaatg gaagacttct ttgcttggtg ccgccgtcag tcagttttat cgggttcaaa
    20521 actaggaagg gcaattgaat acagcctcaa gtatgaagaa acctttaaga ccattttgaa
    20581 agacggacat ctggtccttt ccaataatct agctgaacgc gccattaaat cattggttat
    20641 gggacggagt aaaagagtcc agtggactct tttagcctga gctcagttta aaaaagcgag
    20701 ggtggttgtt ttctcaaagt tttgaaggag ctaaagcaag agctattatt atgagcttat
    20761 tggaaacagc taaacgtcat caattaaata gcgagaaata tctattctat cttctagaat
    20821 gtcttccaaa cgaggaaact ctcgtaaaca aagaggtttt agagcctatt taccatggac
    20881 taaagttgta caagaaaagt gcaaataaga aatctccaga ttaggaacta tccgtgagtt
    20941 ctctagtctg gagatttttc aatatatttc gttattggac ggttacgata ttcatatttt
    21001 ttgcaaagat gttgtttgaa aaataatttt caaaaattct gaaaattctg ttgacatctt
    21061 tctgaaaaga gtctataatg gagagaaagt tttaaaggag aaaatgatga aaagttcgaa
    21121 actatttgcc cttgcgggcg tgacattatt ggcggcgact actttagctg catgctctgg
    21181 atcaggttca agcactaaag gtgagaagac attctcatac atttatgaga cagaccctga
    21241 taacctcaac tatttgacaa ctgctaaggc tgcgacagca aatattacca gtaacgtggt
    21301 tgatggtttg ctagaaaatg atcgctacgg gaactttgtg ccgtctatgg ctgaggattg
    21361 gtctgtatcc aaggatggat tgacttacac ttatactatc cgtaaggatg caaaatggta
    21421 tacttctgaa ggtgaagaat acgcggcagt caaagctcaa gac
//
