LOCUS       CR931714               22917 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 8211/40 (serotype 41f).
ACCESSION   CR931714
VERSION     CR931714.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 22917)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 22917)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..22917
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="8211/40"
                     /db_xref="taxon:1313"
     gene            <1..166
                     /gene="dexB"
                     /locus_tag="SPC41F_0001"
     CDS             <1..166
                     /gene="dexB"
                     /locus_tag="SPC41F_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI34487.1"
                     /db_xref="GOA:Q4JYY3"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4JYY3"
                     /translation="DRRFLVVANLSNDKQNFSVDGKVRSVLIENTAAKEVLEKQVLAP
                     WDAFCVEMTD"
     gene            complement(316..1721)
                     /gene="tnp"
                     /locus_tag="SPC41F_0002"
                     /pseudo
     CDS             complement(join(316..447,447..1721))
                     /gene="tnp"
                     /locus_tag="SPC41F_0002"
                     /note="member of homology group 17"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1202 transposase"
     misc_feature    complement(720..1238)
                     /gene="tnp"
                     /locus_tag="SPC41F_0002"
                     /note="HMMPfam hit to PF00665, Integrase core domain,
                     score 2.1e-17"
                     /pseudo
     gene            1889..3343
                     /gene="wzg"
                     /locus_tag="SPC41F_0003"
     CDS             1889..3343
                     /gene="wzg"
                     /locus_tag="SPC41F_0003"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI34489.1"
                     /db_xref="GOA:Q4JYY2"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4JYY2"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLLFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRMDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1889..2014
                     /gene="wzg"
                     /locus_tag="SPC41F_0003"
                     /note="Signal peptide predicted for SPC1859 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 42 and 43"
     misc_feature    2102..2449
                     /gene="wzg"
                     /locus_tag="SPC41F_0003"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 8.6e-63"
     misc_feature    2627..3070
                     /gene="wzg"
                     /locus_tag="SPC41F_0003"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 5.7e-70"
     gene            3345..4076
                     /gene="wzh"
                     /locus_tag="SPC41F_0004"
     CDS             3345..4076
                     /gene="wzh"
                     /locus_tag="SPC41F_0004"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI34490.1"
                     /db_xref="GOA:Q4JYY1"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JYY1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAEAYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTLDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPYMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    3348..3956
                     /gene="wzh"
                     /locus_tag="SPC41F_0004"
                     /note="HMMPfam hit to PF02811, PHP domain, score 4.1e-38"
     gene            4082..4777
                     /gene="wzd"
                     /locus_tag="SPC41F_0005"
     CDS             4082..4777
                     /gene="wzd"
                     /locus_tag="SPC41F_0005"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI34491.1"
                     /db_xref="GOA:Q4JYY0"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4JYY0"
                     /translation="MMKEQNTIEIDVFQLVKILWKRKLMILLVALVTGAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQEDKPGLTNQDLQAGTYLVKDYREITLSHDVLEKVATNLKL
                     DMPAKTLASKVQVTVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVTVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDFEDVLQI
                     PLLGLVPDLDKMK"
     misc_feature    4082..4198
                     /gene="wzd"
                     /locus_tag="SPC41F_0005"
                     /note="Signal peptide predicted for SPC1861 by SignalP 2.0
                     HMM (Signal peptide probability 0.639) with cleavage site
                     probability 0.424 between residues 39 and 40"
     misc_feature    4103..4519
                     /gene="wzd"
                     /locus_tag="SPC41F_0005"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.1e-53"
     misc_feature    4625..4702
                     /gene="wzd"
                     /locus_tag="SPC41F_0005"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4787..5476
                     /gene="wze"
                     /locus_tag="SPC41F_0006"
     CDS             4787..5476
                     /gene="wze"
                     /locus_tag="SPC41F_0006"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI34492.1"
                     /db_xref="GOA:Q4JYX9"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX9"
                     /translation="MPTLEISQAKLDFVKKAEEYYNALCTNLQLSGDNLRVFSITSVK
                     LGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMSGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGEITRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            5491..6858
                     /gene="wchA"
                     /locus_tag="SPC41F_0007"
     CDS             5491..6858
                     /gene="wchA"
                     /locus_tag="SPC41F_0007"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34493.1"
                     /db_xref="GOA:Q4JYX8"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX8"
                     /translation="MNGKIVKYSLAIIQSFLVILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELIQTLKYILFFALAISISNFFLEDQFSISRRGMIYF
                     LTLHALLVYGLNLFIKWYWKRAYPNFKGSKKILLLTATFRVEKVLDRLIESNEVVGEL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFVTNEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIEDWTIWKDIEILLKTVKVVLM
                     KDGAK"
     misc_feature    5491..5583
                     /gene="wchA"
                     /locus_tag="SPC41F_0007"
                     /note="Signal peptide predicted for SPC1863 by SignalP 2.0
                     HMM (Signal peptide probability 0.776) with cleavage site
                     probability 0.312 between residues 31 and 32"
     misc_feature    6274..6855
                     /gene="wchA"
                     /locus_tag="SPC41F_0007"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 9.2e-158"
     gene            6845..7651
                     /gene="wciB"
                     /locus_tag="SPC41F_0008"
     CDS             6845..7651
                     /gene="wciB"
                     /locus_tag="SPC41F_0008"
                     /note="member of homology group 16"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34494.1"
                     /db_xref="GOA:Q4JYX7"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX7"
                     /translation="MERSRLIDVKIIVATHKEVKMPQDSSLYLPIHVGRDGKSDIGFI
                     GDNTGDNISSLNPYYCELTGLYWAWKNLDYNYLGLVHYRRYFTNKSQGYNENINMDDV
                     ILSRSNVEILLEKSDIIVPKKRKYYIETLYSHYAHTLNGEHLDLARKIIEQNSSEYLS
                     SFDKVMKQRSGYMFNMFIMKKELLDDYLPWLFSILDTMYEQMDLTDHTPFESRLFGRV
                     SELLFNVWLCKKGITPKEVPFMYMERVDLFEKGKSFLMAKFFGKKYGQSF"
     gene            7623..8732
                     /gene="wcrP"
                     /locus_tag="SPC41F_0009"
     CDS             7623..8732
                     /gene="wcrP"
                     /locus_tag="SPC41F_0009"
                     /note="member of homology group 89"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34495.1"
                     /db_xref="GOA:Q4JYX6"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX6"
                     /translation="MERSMDRVFEMLEKESPLFSVIVPTYKISESNLRQCIDSLLYDS
                     QDVEIILVDDNKNLDICGKVLDEYAEKYNNISVIHQENQGVSVARNAGMSIAVGKYLI
                     FVDPDDWVAENFYSQMTLAVQKNPSSDVIILAAIVDYNGKQFTNHFWHTSRSFQGTDK
                     DDLELQLIAKGATSYFPTEIGVGVPWAKIYRNEFVRENGLDFNPSLRRMQDNIFNMYA
                     FEFANEIVYIDEPIYYYRKSMDSVTNKKNDKVIYYFDLVNDEVEKFIQKFNKPKIFED
                     ALHIKRLIGINSYYKLYFQFATTSSEKKKMRQEFRELLEREEYANSLKQVNTAYLLPK
                     EKIFISILKQKHLRIFSFLQKLEKLSARLKSRHFS"
     misc_feature    7680..8219
                     /gene="wcrP"
                     /locus_tag="SPC41F_0009"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 1.6e-30"
     gene            8740..9657
                     /gene="wcrQ"
                     /locus_tag="SPC41F_0010"
     CDS             8740..9657
                     /gene="wcrQ"
                     /locus_tag="SPC41F_0010"
                     /note="member of homology group 106"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34496.1"
                     /db_xref="GOA:Q4JYX5"
                     /db_xref="InterPro:IPR008441"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX5"
                     /translation="MRQLTLKLVSIIYKVTKRIPISFISNLGERIYSLKDSYVFDVLS
                     KLGVDKESTYDLMPPDLFLNKIWICWFQGEDKAPDLVKKCINSVRKHASGYDVIILTE
                     DNIEEYVTLPNIVLTKYKNGLFSRTHFSDIVRLNLLAQQGGLWIDATIFMTRDLDLSI
                     FFKNDFVSLRTTIKSSPLFITGYWTTYFVYMPSNFKLVQYTALLLNKYIEKYDRFIDY
                     FLQDYIITKAIKDLNYESYMEERPVLGNQRWLLADLANKVVTSELLQQFKQDTVGIYK
                     VTYKSKYIRKKNGRETVYKKIVEDGECLE"
     misc_feature    8791..9630
                     /gene="wcrQ"
                     /locus_tag="SPC41F_0010"
                     /note="HMMPfam hit to PF05704, Capsular polysaccharide
                     synthesis protein, score 2.8e-47"
     gene            9638..10528
                     /gene="wcrR"
                     /locus_tag="SPC41F_0011"
     CDS             9638..10528
                     /gene="wcrR"
                     /locus_tag="SPC41F_0011"
                     /note="member of homology group 90"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34497.1"
                     /db_xref="GOA:Q4JYX4"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX4"
                     /translation="MENALNNKIGIVILNYLNWEDTLECINSLRSQSDQDFEAVIVEN
                     GSPNESVSRIRDYIKNDKNIHLYVVENNLGYANGNNMGILYLKNRYSINRILLTNNDV
                     IFDDEDYIKKLEDIKYSNTIGAIGTKIIGSDGLNQNPAYFPISFSSSIKSLLINLLAF
                     SKVITFIKKRFLSSWTKRANDFSNPKTDEQKYFLHGSVIFLTENYLDRFMGLYGGTFL
                     YYEEVILGIIFEKAGLDMLYVPDFSIYHKEDQSSLESFANDDLIRRKFLLKSIFSSFK
                     VHFCATNRLSILVKESIKYD"
     misc_feature    9665..10165
                     /gene="wcrR"
                     /locus_tag="SPC41F_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 1.9e-13"
     gene            10521..11780
                     /gene="wzy"
                     /locus_tag="SPC41F_0012"
     CDS             10521..11780
                     /gene="wzy"
                     /locus_tag="SPC41F_0012"
                     /note="member of homology group 121"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI34498.1"
                     /db_xref="InterPro:IPR007016"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX3"
                     /translation="MIKFNYSKLALIYQFIIIFFLGAWYKNSIQFKIFLISIDTIISL
                     FYLYKNNLSRSDLKKVYILITTVLVSLFLPSFMNRVSFILLILQKLYIFNHIINDIKF
                     EYLLSVFLQFIVLLTFCMGLEFISLGQFNPFKTFYAPRVLLDMSFKVGTPLYFLRSSL
                     EHPLITSIILVVTGPFLFLLEKKWLRYVCVFLNISLIFFIQKRTAYILVSIGVVCFAL
                     YYLKYINRRFQLNKITSVIFLMTLFIIALSFIRVQGDYVLNIIFSKFSALQDADSFSL
                     NNRVINAKTGLDVIFDQNVINIFIGNGYDFLPNFFEQYNVYVIRNGFYVIDNTYISFL
                     ADYGMIGLFLVLLYIINAIRKSMTNIYKIKSKKEQLFMLYSIIGIINLMVSIAFFDIY
                     AWYTPLTLLIFLISVVTSYCKFHSNKF"
     gene            11822..13066
                     /gene="wcrW"
                     /locus_tag="SPC41F_0013"
     CDS             11822..13066
                     /gene="wcrW"
                     /locus_tag="SPC41F_0013"
                     /note="member of homology group 122"
                     /codon_start=1
                     /transl_table=11
                     /product="conserved hypothetical protein"
                     /protein_id="CAI34499.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX2"
                     /translation="MTLKNEVKNIKRTIEKNFFHKDFTSISDIKNYQIEISKNLRPRL
                     NLLITSMNSQDVYAGIKSAVDFFMKFKKFDIDLRIIVMGKKIDEPSLYQVPGFEFIKD
                     YSIENDSESRIICDLSKNRSPLFIRERDYFLSTMWYTAYNANNVLDEQKRIFGKRMPM
                     VYLVQDYEPGFYPWSSEYLLAESTYHLDNQLVVFNSKYLKEFFDANGYRFENSYYFDP
                     VLNEKLGEILNSAELSNIERKNRILFYGRPSKARNAFQLICMALEKWSVLDERSSNWE
                     IFSAGEDLKDIKLNNSIVIKSLGKMSVEEYAKFMLESKIGISLMASPHPSYPPLEMAT
                     FGMKVITNSFVTKDISDFNENIISIEHININKLAEELHFLTTSDIEYKISKNDDYING
                     ISQLDTIVDEIAGHLQFRHSEV"
     gene            13069..14511
                     /gene="wzx"
                     /locus_tag="SPC41F_0014"
     CDS             13069..14511
                     /gene="wzx"
                     /locus_tag="SPC41F_0014"
                     /note="member of homology group 123"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI34500.1"
                     /db_xref="GOA:Q4JYX1"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX1"
                     /translation="MKRKSIARNYLLNLIKTTLSILFPLISYPYVSRILSVDGLGAIN
                     FSTSFVNYFVLIAIFGINVYAVREGAKYRDDKKLLGKFVTEMLLVSICMAMISFSLLT
                     ISLLLPALSEYRSLILIFSITILFNVVGMEWFFQLMEDYQYITLRAIIFQILSLLSLF
                     IFVKDRNDIYVYALITVAANAGSQMLNLFRLRKEVEIFRYKDYNIRHYFKPMFLIFLT
                     LLSMNIYRYLDVTFLGFFKNDQSVGYYSLATKITNVIISMVSSVTVILTPRLAYHYKQ
                     KEFDKFYKIAYSSFDFILLLAIPVVIGVLSFSSILVDFLGGSAFISSVLTVEILSLTI
                     LFSNLNALLITPILTVMNHEKAVLKIFIIALIFNVIANMFLIPVMDFNGSALVTVLTE
                     GIICILSLISIKNVFDVKRLFKNLFQYLVASIFIIVVKIVISQYVSSNYIIFISTALL
                     SAILYFFTLILLRNELVSQLIIEVRKKIYR"
     misc_feature    13084..13890
                     /gene="wzx"
                     /locus_tag="SPC41F_0014"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 1.3e-44"
     gene            14527..15207
                     /gene="wcrX"
                     /locus_tag="SPC41F_0015"
     CDS             14527..15207
                     /gene="wcrX"
                     /locus_tag="SPC41F_0015"
                     /note="member of homology group 124"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34501.1"
                     /db_xref="GOA:Q4JYX0"
                     /db_xref="InterPro:IPR011004"
                     /db_xref="UniProtKB/TrEMBL:Q4JYX0"
                     /translation="MFTIYRAMKKIIIIILSLPKIFYINLKCLPLNQAVKLPIYVHFN
                     TRLMIKGDIKIIDTHLSRFTIILGKDGSNHISPHESRLFIYDGGQLILGRNILLSSGF
                     NLCIEQGGTVKLGDNVSFNRNSSIFCKKQINIGKNSLFGWNCSLRDNNGHRIYYQDNC
                     IKSEEVIVIGENCWITADSVILKNSVLPFSTVVATGSLVNKEFNQSNILIAGRPARII
                     REDIKWER"
     gene            15275..16495
                     /gene="ugd"
                     /locus_tag="SPC41F_0016"
     CDS             15275..16495
                     /gene="ugd"
                     /locus_tag="SPC41F_0016"
                     /note="member of homology group 20"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase Ugd"
                     /protein_id="CAI34502.1"
                     /db_xref="GOA:Q4JYW9"
                     /db_xref="InterPro:IPR001732"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR014026"
                     /db_xref="InterPro:IPR014027"
                     /db_xref="InterPro:IPR014028"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR017476"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW9"
                     /translation="MKIAVAGTGYVGLSIAVLMAQHHEVVAVDIISEKVNLINNGKSP
                     IKDDYIEEYLASKPLNLVATLDTNIAYQNADFVIIAAPTNYDSEKNFFDTSAVEAVIE
                     TVLETNPNAVMVIKSTVPVGYTQSIRNKYKTNNILFSPEFLRESKALYDNLYPSRIIV
                     GLDMDDAYLKERAETFAELLQEGAIKENIEILYMGFTEAEAVKLFANTYLALRVSYFN
                     ELDTYAEVKGLDTKAIIEGVGLDPRIGSQYNNPSFGYGGYCLPKDSKQLLANYKDVPQ
                     NMITAIVESNRTRKDFIAEQILKFAGVSSNGEIHPKDVIIGLYRLTMKSNSDNFRQSS
                     IQGVMKRLKAEGTNVIIYEPTLSDDETFLGSKIVNDLEHFKSISNVIVANRYDDLLKD
                     VSDKIYSRDIFKRD"
     misc_feature    15275..15829
                     /gene="ugd"
                     /locus_tag="SPC41F_0016"
                     /note="HMMPfam hit to PF03721, UDP-glucose/GDP-mannose
                     dehydrogenase, score 1.8e-51"
     misc_feature    15860..16141
                     /gene="ugd"
                     /locus_tag="SPC41F_0016"
                     /note="HMMPfam hit to PF00984, UDP-glucose/GDP-mannose
                     dehydrogenase, score 1.9e-36"
     misc_feature    16223..16474
                     /gene="ugd"
                     /locus_tag="SPC41F_0016"
                     /note="HMMPfam hit to PF03720, UDP-glucose/GDP-mannose
                     dehydrogenase, score 3.1e-06"
     gene            16508..17608
                     /gene="glf"
                     /locus_tag="SPC41F_0017"
     CDS             16508..17608
                     /gene="glf"
                     /locus_tag="SPC41F_0017"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI34503.1"
                     /db_xref="GOA:Q4JYW8"
                     /db_xref="InterPro:IPR003953"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW8"
                     /translation="MYDYLIVGAGLSGAIFAHEATKCGKKVKVIDKRDHIGGNIYCEN
                     VEGINVHKYGAHIFHTSNKKVWDYVNQFAEFNNYINSPVANYKGSLYNLPFNMNTFYA
                     MWGTKTPQEVKDKIAEQTAGMKDVEPKNLEEQAIKLIGPDIYEKLIKGYTEKQWGRSA
                     TELPPFIIKRLPVRLTFDNNYFNDRYQGIPIGGYNVIIENMLKDVEVELGVDFFAHRE
                     ELEASANKVVFTGMIDQYFDYKHGELEYRSLRFEHEILDEENYQGNAVVNYTEREIPY
                     TRIIEHKHFEYGMQPKTVITHEYPADWKRGDEPYYPINDEKNNAMFAKYQEEAAQNDK
                     VIFCGRLADYKYYDMHVVIERALEVVEKEFSN"
     misc_feature    16943..17545
                     /gene="glf"
                     /locus_tag="SPC41F_0017"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 5.3e-139"
     gene            17636..18505
                     /gene="rmlA"
                     /locus_tag="SPC41F_0018"
     CDS             17636..18505
                     /gene="rmlA"
                     /locus_tag="SPC41F_0018"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI34504.1"
                     /db_xref="GOA:Q4JYW7"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW7"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLT
                     GIKDILIISTPQDLPRFKDLLLDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSV
                     ALILGDNIYHGPGLSTMLQKAAKKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEK
                     PEHPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLGRGDLSVEVMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLTLAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    17639..18355
                     /gene="rmlA"
                     /locus_tag="SPC41F_0018"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 1e-117"
     gene            18506..19102
                     /gene="rmlC"
                     /locus_tag="SPC41F_0019"
     CDS             18506..19102
                     /gene="rmlC"
                     /locus_tag="SPC41F_0019"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI34505.1"
                     /db_xref="GOA:P97005"
                     /db_xref="HSSP:1NZC"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:P97005"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    18542..19072
                     /gene="rmlC"
                     /locus_tag="SPC41F_0019"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.8e-16"
     gene            19112..20161
                     /gene="rmlB"
                     /locus_tag="SPC41F_0020"
     CDS             19112..20161
                     /gene="rmlB"
                     /locus_tag="SPC41F_0020"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI34506.1"
                     /db_xref="GOA:Q4JYW5"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW5"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPGVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGGIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQATD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    19127..20083
                     /gene="rmlB"
                     /locus_tag="SPC41F_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00022"
     misc_feature    19130..19870
                     /gene="rmlB"
                     /locus_tag="SPC41F_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 9e-74"
     misc_feature    19133..19945
                     /gene="rmlB"
                     /locus_tag="SPC41F_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 7.5e-05"
     gene            20227..21078
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
     CDS             20227..21078
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI34507.1"
                     /db_xref="GOA:Q4JYW4"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW4"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAAFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    20227..21075
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 3.8e-147"
     misc_feature    20230..20811
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00018"
     misc_feature    20230..20859
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 4.8e-18"
     misc_feature    20233..20961
                     /gene="rmlD"
                     /locus_tag="SPC41F_0021"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.5e-08"
     gene            order(21225..22030,22032..22325)
                     /gene="glf"
                     /locus_tag="SPC41F_0022"
                     /pseudo
     CDS             join(21225..21725,21725..22030,22032..22325)
                     /gene="glf"
                     /locus_tag="SPC41F_0022"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
     misc_feature    join(21561..21725,21725..22030,22032..22181)
                     /gene="glf"
                     /locus_tag="SPC41F_0022"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 9.6e-104"
                     /pseudo
     gene            22559..>22917
                     /gene="aliA"
                     /locus_tag="SPC41F_0023"
     CDS             22559..>22917
                     /gene="aliA"
                     /locus_tag="SPC41F_0023"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34509.1"
                     /db_xref="GOA:Q4JYW3"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW3"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKD
                     AKWYTSEGEEYAAVKAQ"
     misc_feature    22559..22645
                     /gene="aliA"
                     /locus_tag="SPC41F_0023"
                     /note="Signal peptide predicted for SPC1879 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
     misc_feature    22805..22873
                     /gene="aliA"
                     /locus_tag="SPC41F_0023"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     7399 a   3437 c   4638 g   7443 t
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt atccaatgac aaacaaaact tttcagtaga
       61 tggaaaagtt agatctgtct tgattgaaaa cactgcggct aaagaagtac ttgaaaaaca
      121 ggtcttggcc ccatgggatg ctttctgtgt ggaaatgact gactagaatg agcaaacctc
      181 aagcttttga agcttgaggt tttttactat agtagattga aactggaata gtacacctct
      241 acttctaaaa cattgttaga aatcgatttg attgtcctga tcgatttgtc ctattcttat
      301 ttcattttac tatgcttgta gttgaggaga attaagctcc tcactagtaa actcttcata
      361 atccttttta tttttatgaa gatattgttt gaaagatgtg agtttccacg gataggtttg
      421 tggagggata tacttgcgtc tttctttttt tgttctggtt cttgttcaaa gtttttcgaa
      481 tagagttcat gatctagtag ctcctttgtg cgatagattt tgtcagcgat attgaggtag
      541 atgtctccgt caaatgcttt tataactaat gctttcgtct ttctgatgaa atagacttct
      601 ttttcttgtt cggtagggat atagtaacga ttttggaatc ggatatggtg tccactatcg
      661 gcgactctct ccgccagtct agccagaatg agattccttt cagaggggtt aggaacctcc
      721 tcgaagacag agagttttgt cttgtttcca aactgttcat taaaggtttg gatgtaggaa
      781 agcaggaagg tcttggcttc ttccaaggta tgaatcttgt ttcgttccag ttcgataggc
      841 aggcgagatt gtagtgtctg atggagtctt tcgactctcc ctttagcttg agggatagag
      901 gttgtctcca gaagaatccc cagttggtga caggcgtatc cgaattgtgt atgagtgtcg
      961 tcctccattt tcttagagtt ggagacttga taggtaaaga ctgttctttt atctgttttg
     1021 atttgaaggg gaatgccgtg attgcctaaa atttgttcga ggacatgata gtaagtattc
     1081 aaggtctctt gtttatcaaa ataagcgcct aaaaaataag cgcctaagat attgccagaa
     1141 gcatcatcaa tggctaagtg taagttagat gtttgtgctc caaaccaggc atgagggctg
     1201 gcatccattt gaatgagttc accagcaaat ttctttctgg gtctactagg atgtactttt
     1261 ttagggtctt caaggaagtt ttcagccgtc ggtaagattg gattatctag gggttgcttg
     1321 gggttcagtt tagcttgttt tcttactctc ttctttgtct ttctatgaga cttaggcgac
     1381 aggatgtttt ccttatagag tatttttcta acagttgtat cagagagctg aattccttct
     1441 tcttcagcta gcaattcaca gaaatgaagg acatttggtt tatatgtttc ataggagagg
     1501 tattttttta ggagacgttc tttgatttca tcagggattg catgttttgg ttttcgattt
     1561 ctgtttccgt gtctgaaggc ttcttttcct ttcagttgat aggctagtag cagacgattg
     1621 atttgccttt cagaaagatt gagttcggca caggctcgtt tctttgtttt ctttccttgg
     1681 gctatagctt ttatcacaag atattttttc atttcattca tatttagttg gatccttttc
     1741 atatgactat tctaccaaat gggacatttt cacgttcgat ttactaaaga cattatcacc
     1801 ttcgaatcac aaagatgcag atagtgaaaa taaaggtgta gacattaccg taaaaaagtg
     1861 atataatcgt aagatgttca atgtataggt gttaatcatg agtagacgtt ttaaaaaatc
     1921 acgttcacag aaagtgaagc gaagtgttaa tatagttttg ctgactattt atttattgtt
     1981 agtttgtttt ttattgttct taatctttaa gtacaatatc cttgctttta gatatcttaa
     2041 tctagtggta actgcgttag tcctactagt tgccttggta gggctactct tgattatcta
     2101 taaaaaagct gaaaaattta ctatttttct gttgctgttc tctatccttg tcagctctgt
     2161 gtcgctcttt gcagtacagc agtttgttgg actgaccaat cgtttaaatg cgacttctaa
     2221 ttactcagaa tattcaatca gtgtcgctgt tttagcagat agtgatatcg aaaatgttac
     2281 gcaactgacg agtgtgacag caccgactgg gactgataat gaaaatattc aaaaactact
     2341 agctgatatc aagtcaagtc agaataccga tttgacggtc aaccagagtt cgtcttactt
     2401 ggcagcttac aagagtttga ttgcagggga gactaaggcc attgtcctaa atagtgtctt
     2461 tgaaaatatc atcgagtcag agtatccaga ctacgcatcg aagataaaaa agatttatac
     2521 caagggattc actaaaaaag tagaagctcc taagacgtct aagaatcagt ctttcaatat
     2581 ctatgttagt ggaattgaca cctatggccc tattagttcg gtgtcgcgat cagatgtcaa
     2641 tatcctgatg actgtcaatc gagataccaa gaaaatcctc ttgaccacaa cgccacgtga
     2701 tgcctatgta ccaatcgcag atggtggaaa taatcaaaaa gataaattaa cccatgcggg
     2761 catttatgga gttgattcgt ccattcacac cttagaaaat ctctatggag tggatatcaa
     2821 ttactatgtg cgattgaact tcacttcttt cttgaaaatg attgacttat tgggaggggt
     2881 agatgttcat aatgatcaag agttttcagc tctacatggg aagttccatt tcccagtagg
     2941 gaatgtccat ctagactctg agcaggctct aggttttgtt cgtgagcgct actcactagc
     3001 agatggcgat cgtgaccgcg ggcgcaatca acaaaaggtg attgtggcta tccttcaaaa
     3061 attaacgtca accgaagcac tgaaaaatta tagtacgatc attaatagct tgcaagattc
     3121 tatccaaaca aatatgccac ttgagactat gataaatttg gtcaatgctc agttagaaag
     3181 tggagggaat tataaagtaa attctcaaga tttaaaaggg acaggtcgga tggatcttcc
     3241 ttcttatgca atgccagaca gtaacctcta tgtgatggaa atagatgata gtagtttagc
     3301 tgtagttaaa gcagctatac aggatgtgat ggagggtaga tgaaatgata gacatccatt
     3361 cgcatatcgt ttttgatgta gatgacggtc ccaagtcaag agaggaaagc aaggctctct
     3421 tggcagaagc ctacagacag ggggtgcgaa ccattgtctc tacctctcac cgtcgcaaag
     3481 gcatgtttga aactccggaa gagaagatag cagaaaactt tcttcaggtt cgggaaatag
     3541 ctaaggaagt ggcgagtgac ttggtcattg cttacggggc tgaaatttac tacacactag
     3601 atgttctaga taagctggaa aaaaagcgga ttccgaccct caatgatagt cgttatgcct
     3661 tgatagagtt tagtatgaac actccttatc gcgatattca tagcgccttg agcaagatct
     3721 tgatgttggg aattactcca gtcattgccc acattgagcg ctatgatgct cttgaaaata
     3781 atgaaaaacg cgttcgagaa ctgatcgata tgggctgtta cacgcaagta aatagttcac
     3841 atgtcctcaa acccaaactt tttggcgaac gttataaatt catgaaaaaa agagctcagt
     3901 attttttaga gcaggatttg gttcatgtca ttgcaagtga tatgcacaat ctagacggta
     3961 gacctcctta tatggcagaa gcatatgacc ttgttaccca aaaatacgga gaagcgaagg
     4021 ctcaggaact ttttatagac aatcctcgaa aaattgtaat ggatcaacta atttaggaga
     4081 aatgatgaaa gaacaaaaca cgatagaaat cgatgtattt caattagtta aaatcttgtg
     4141 gaaacgcaag ctaatgattt tattagtggc acttgtgaca ggtgcggggg cttttgcata
     4201 tagcactttt attgttaagc cagaatatac gagtaccacg cgaatttacg tagtgaatcg
     4261 caatcaagaa gacaagccgg ggctgacaaa tcaggatttg caggcaggaa cttatctggt
     4321 aaaagattac cgtgagatta ccctttcgca tgatgtattg gaaaaagtag cgacaaattt
     4381 gaagttggat atgccagcaa aaacgttagc cagcaaagtt caagtgactg taccagctga
     4441 cactcgtatc gtctcaatct ctgtcaagga taaacagcca gaggaagcca gtcgtatcgc
     4501 taattctcta cgagaagttg ctgcagaaaa gatcgtcact gtaacgcgag tatctgatgt
     4561 aacgacactt gaagaagcgc gaccagctac gactccctct tctccaaatg ttcgacgcaa
     4621 ttccttgttt ggttttcttg gaggagcagt cgtaacagta attgctgttc ttttgattga
     4681 gttgctcgac acccgtgtga aacgtcctga agatttcgaa gatgtactgc aaattccact
     4741 tttagggctc gttccagatt tagacaaaat gaaataggag gaagttatgc caacgttaga
     4801 aatctcacag gcaaaattgg attttgtaaa aaaggcagag gaatattata atgccttgtg
     4861 cacgaaccta cagttaagtg gagataattt aagagtattt tctatcactt ctgtgaaact
     4921 aggagaagga aaatcaacga cttccaccaa tatcgcttgg gcttttgcgc gtgcaggtta
     4981 caaaacgctg ctgattgatg gagatattcg caattctgtt atgtcaggtg tctttaaagc
     5041 aagggataag attacaggcc tgacagaatt tttatcagga actacagacc tatcacaagg
     5101 gctttgtgat accaatatcg aaaatctctt tgtaattcag gctggctctg tgtcaccgaa
     5161 tccgacagct cttcttcaaa gtaagaattt cagtacaatg cttgaaacct tgcgtaaata
     5221 ttttgactac atcattgtag atactgctcc tgtcggtgtc gtgattgatg cggctattat
     5281 tacgcgaaaa tgcgatgctt ctattttagt gacggaggca ggtgaaataa ctcgacggga
     5341 tattcaaaaa gcaaaagaac agttggaaca cacagggaag ccgtttttgg gagttgtgtt
     5401 gaataaattc gatacttcag tagacaaata cggttcttat ggaaattatg gagattacgg
     5461 gaaaaataaa aaataggtcg ggggatagag atgaacggaa aaatagtaaa gtattcattg
     5521 gccataatcc agagttttct tgttatttta ttgacttatc tacttagtgc tgtgagagaa
     5581 gcggagattg tttcaacaac agctattgca ctttatatcc tccattattt tgtcttttat
     5641 atcagtgatt atggacagga tttctttaaa aggggatatt tgattgaact tatccagaca
     5701 ttgaaatata tcctattctt tgcactagcg attagtatct ctaatttttt cttagaggat
     5761 caatttagta tttccagacg aggcatgatt tacttcctca cattacatgc tctcttagtc
     5821 tatgggctaa acctatttat caagtggtat tggaagcggg cttatcccaa ctttaaagga
     5881 agtaagaaga ttctcctact tacagcaact tttcgtgtcg aaaaggtact ggatagatta
     5941 atagaatcaa atgaggttgt tggggagttg gtagctgtca gtgtcttaga taaaccagat
     6001 tttcagcatg attgtttaaa ggtagtagca gagggggaga tagtaaactt tgtgactaat
     6061 gaggtggtcg atgaagtctt tatcaatctt ccaagtgaaa aatacaatat tggagagctt
     6121 gtctctcagt ttgaaacgat gggaattgat gtaacagtca atctaaatgc ttttgatcgt
     6181 agtttggcac gtaacaagca aattcgtgag atggcaggat taaacgttgt gactttttct
     6241 acaacatttt ataagactag tcatgtaatt gctaagcgga ttattgatat catgggtgca
     6301 ttggtagggc tgatactatg tggtttagtc agtattgtac tggttccttt gattcgaaag
     6361 gatgggggct ctgctatttt tgctcagacg cgtataggaa aaaatggtcg tcagttcact
     6421 ttttataagt ttcgctctat gtgtgtagat gccgaggcga aaaaaagaga actcatggaa
     6481 caaaatacca tgcagggtgg aatgtttaag gtggacgatg atcctcgtat cacgaaaatt
     6541 ggtcgtttta tacggaagac tagcttggac gagctaccac agttttataa tgttctaaag
     6601 ggagatatga gtttggttgg cacacgacca ccaacagtgg acgagtatga acactataca
     6661 ccagaacaaa aacgtcgtct gagttttaaa cctggcataa cagggttatg gcaggtcagt
     6721 ggacgaagtg agattaagaa ttttgatgaa gttgtcaaat tagatgtagc ctatatagaa
     6781 gattggacaa tttggaaaga tattgagatt ttattgaaga cagttaaagt tgtattgatg
     6841 aaggatggag cgaagtagat tgatagatgt aaaaatcatt gtggcaacac ataaagaggt
     6901 taaaatgcct caagacagta gtctttacct tccaatacat gttgggagag acggtaaatc
     6961 agatattggt tttatcggtg ataatactgg cgataatata tcctctttaa atccatatta
     7021 ttgtgagttg acgggacttt attgggcatg gaaaaatctt gattataatt acttaggttt
     7081 agttcattac cgtcgttatt ttacaaataa atctcaaggg tataatgaaa atatcaatat
     7141 ggatgacgtc attttgtctc gatctaatgt tgaaatatta ttagagaaat ctgacataat
     7201 agttccaaag aagcgaaagt attatattga aactctttat tcacattatg cccataccct
     7261 taacggcgaa catctggatc ttgctaggaa aattattgag caaaatagtt cagagtatct
     7321 ttcatccttt gataaagtga tgaaacaaag aagcggttat atgttcaata tgtttatcat
     7381 gaaaaaagaa ctattagatg attatttacc gtggcttttt tctattctgg atactatgta
     7441 cgaacagatg gacttgaccg accatactcc atttgagtca cgtttattcg ggcgagttag
     7501 tgagttgttg tttaatgttt ggttatgtaa aaaaggaata acgcctaaag aggtaccatt
     7561 tatgtacatg gagagagtgg atttgtttga aaaaggaaaa tcttttttaa tggctaaatt
     7621 ttttggaaag aagtatggac agagtttttg aaatgttaga aaaagaatct ccacttttta
     7681 gtgttattgt tccaacctat aagatatcag aatctaatct acgccaatgt atagactctc
     7741 tgttatatga tagtcaagat gttgagatta ttttggtaga tgacaataaa aacttggata
     7801 tatgtggaaa agtgttggac gaatatgctg aaaaatataa taatatttca gttattcatc
     7861 aagaaaacca aggtgtgtca gtcgcaagaa atgctggtat gtcaattgct gtaggaaagt
     7921 atcttatttt tgtagatccc gatgattggg ttgctgaaaa tttttatagt caaatgactc
     7981 ttgcggttca aaaaaatcct tcaagcgatg tgattatatt agctgctatt gtagactaca
     8041 atggtaaaca atttacgaat catttttggc acacctctcg ttcttttcag ggaacagata
     8101 aagatgatct ggaacttcaa ttgattgcta aaggagcaac gagttatttc ccaactgaga
     8161 taggggttgg tgttccctgg gcaaaaattt atcgtaatga gtttgtgcga gaaaatggct
     8221 tagattttaa tccttctctt cgccgaatgc aagataatat tttcaatatg tatgcattcg
     8281 aatttgcgaa tgaaatcgtc tacattgatg agccgattta ctattataga aagagtatgg
     8341 atagtgtaac taataagaaa aatgataaag taatttatta tttcgactta gttaatgatg
     8401 aggttgaaaa atttattcaa aaatttaata aacctaaaat atttgaagat gctctacata
     8461 taaaaagact tataggtatc aattcgtatt ataagttgta ttttcagttt gcgactactt
     8521 caagcgagaa aaagaaaatg cgacaagaat ttcgtgaact tttagaaagg gaagaatatg
     8581 caaattcgtt aaaacaagtg aatacagcct atcttctccc aaaagaaaaa atttttataa
     8641 gtattttaaa gcagaaacac ttgcgaatat tttccttttt acaaaaactt gaaaaattat
     8701 ctgcgagatt aaagagccgt cattttagtt agagggaata tgagacagtt aacattaaaa
     8761 ttagttagta tcatttataa agtaacaaaa cgaataccta tatcttttat ttctaattta
     8821 ggcgagagga tttattcact aaaggattcc tatgtttttg acgtattaag taaattggga
     8881 gtcgataaag agagcaccta tgatttgatg ccaccagatt tatttttgaa taaaatttgg
     8941 atttgctggt ttcagggtga ggataaagca ccagatttag taaaaaagtg catcaatagt
     9001 gttagaaaac atgcctcagg ctacgatgtc attattttaa cggaagataa tatagaagaa
     9061 tatgttacac ttccaaatat tgttttaaca aaatataaaa atgggttatt tagccggact
     9121 catttttcgg atatagttcg attgaatctt cttgcacaac agggagggct ttggattgat
     9181 gcaacgattt ttatgactag ggatttagat ttgtctatat ttttcaaaaa tgattttgta
     9241 agcttgagaa ctacaataaa atctagtcct ctttttatta cggggtactg gacgacatat
     9301 tttgtatata tgccctctaa ttttaaattg gttcaatata ctgctttatt attaaataaa
     9361 tacattgaga aatatgatcg ctttatagat tatttcttac aagattatat aattactaag
     9421 gcaattaaag atttgaatta tgaatcatac atggaagaac ggcctgtatt gggaaatcaa
     9481 cgttggcttt tagcagattt agctaataaa gttgtgacct cagaacttct tcaacaattt
     9541 aaacaagata cggtaggaat ttataaagtg acatataaat ccaagtatat tagaaaaaaa
     9601 aatggtaggg aaacggttta taaaaaaatt gtagaggatg gagaatgcct tgaataataa
     9661 aataggaatt gttattttaa attatcttaa ttgggaggat actttagaat gcataaatag
     9721 tttgcgctca caaagtgatc aagattttga agctgtcata gtagaaaatg gttctccaaa
     9781 tgaatctgtt tctaggatta gagattatat aaaaaatgac aagaatattc atctttatgt
     9841 agtagagaat aacttaggtt atgcaaatgg aaataatatg ggcatcctct acttaaaaaa
     9901 tagatactct ataaatagaa ttctattaac taataatgat gttatttttg atgatgaaga
     9961 ctacataaaa aaattagaag atattaagta tagtaatacc attggagcta ttggaacaaa
    10021 aattattggt tctgatggtt taaaccaaaa tccagcttat tttccaattt cttttagttc
    10081 tagtataaaa tcacttctta ttaacttatt ggcattttct aaagttatca cttttatcaa
    10141 aaagcgtttt ctatcttcat ggacgaaaag agctaatgac ttttcaaatc caaaaaccga
    10201 tgaacaaaaa tacttcctac atggatcagt catttttctt acggaaaatt atttagatag
    10261 gtttatggga ttgtatggag ggacttttct ttactatgaa gaagtaatcc taggtattat
    10321 atttgaaaaa gcaggtcttg atatgttgta tgtacctgac ttttcaattt accataaaga
    10381 agatcaatca tctttggaaa gttttgcaaa tgatgatttg attaggcgta aatttttatt
    10441 gaaaagcata ttctctagct ttaaggtaca tttttgtgca acgaatagac tctctatact
    10501 ggtgaaggag tcaataaagt atgattaaat ttaattattc taaattagca ttaatttacc
    10561 agtttataat aatttttttt ctgggtgctt ggtataagaa tagcattcag tttaaaattt
    10621 ttttgatatc tattgatact atcatttctt tattttattt atataaaaat aatttatcta
    10681 gaagtgactt aaaaaaagtt tatatcttga taactacagt gttagtaagc ttatttttac
    10741 catcgtttat gaatagagta tcttttatac ttctcatatt gcaaaaatta tatatattta
    10801 accatattat taatgatata aagtttgaat atttgctctc agtctttcta caatttattg
    10861 tactactaac cttttgtatg ggattagaat tcatttcatt aggacaattt aatccgttta
    10921 aaacatttta tgcaccaaga gttcttcttg atatgagttt taaagtcgga acacctttat
    10981 attttttgag atcaagttta gagcatcctc taataacttc gattatatta gtagttactg
    11041 gccctttctt attcctttta gaaaagaaat ggttgagata tgtatgtgtg tttctaaata
    11101 ttagtttaat cttttttatt cagaagagaa ctgcgtatat attggtatcg attggagttg
    11161 tatgttttgc tttgtattat ctaaaatata ttaatcgtag atttcaattg aataaaataa
    11221 cttcagtgat atttttaatg acactattta taattgcttt atcctttata agggtgcaag
    11281 gtgattatgt attaaatatt atttttagta aattttctgc tttacaagat gcagatagtt
    11341 tctcgctaaa taatcgtgta attaatgcta aaactggatt agatgtaatt ttcgatcaaa
    11401 atgttataaa tatattcatt gggaatggat atgacttttt acctaatttt tttgaacaat
    11461 acaatgtgta tgtaattcgg aatggttttt atgtgattga caatacatat atttcatttc
    11521 ttgccgacta tggaatgatt ggtctgttct tagtattgtt atatattata aatgcgatcc
    11581 gaaaaagtat gactaatatt tacaaaataa agagtaaaaa agaacaatta tttatgttgt
    11641 atagtattat aggtattatc aatttgatgg tatcaatagc tttttttgat atatatgctt
    11701 ggtacacgcc attaacgtta ttgatttttt taatatcagt agtgacttct tattgtaaat
    11761 ttcattccaa taagttttag tgtgtacaat cattataatt agcaaaaaga aggaaatctg
    11821 aatgactctc aaaaacgaag ttaaaaacat aaaacgaaca atagaaaaaa atttttttca
    11881 taaggatttt acatctatat ctgatattaa gaattatcag attgaaattt ctaagaatct
    11941 aaggccacgt cttaatttat taattacttc aatgaactct caggatgtat atgctggcat
    12001 caaatcagca gtggattttt ttatgaagtt caaaaaattt gatatagatt taagaatcat
    12061 tgtaatggga aaaaaaatcg atgaaccgtc tctttatcaa gttcctggtt ttgaatttat
    12121 taaagactat tcaattgaga atgatagtga gtctaggatt atttgcgatt tatctaagaa
    12181 tcgttctcca ttgtttatta gggagcgtga ttattttcta tcaacaatgt ggtacactgc
    12241 ttataatgct aacaatgtgc tggatgagca aaaaagaatt tttgggaaac ggatgcccat
    12301 ggtttatcta gttcaagact atgaaccagg tttctatcca tggtcctcag agtatctttt
    12361 ggctgagagc acatatcatc tagataacca gcttgttgtc tttaattcta agtatttaaa
    12421 agaatttttt gatgcaaatg gttatagatt tgaaaatagt tattattttg atccagtttt
    12481 aaatgaaaaa ttgggggaga ttcttaattc agcagagctt tctaatattg aaaggaaaaa
    12541 tcgtatttta ttttatggaa ggcctagtaa agctagaaat gcttttcagt taatctgtat
    12601 ggcattggaa aaatggagcg ttttggacga acgtagttca aattgggaaa ttttttctgc
    12661 aggagaagat ttaaaagata ttaaattgaa taatagcata gtaataaaat cgttagggaa
    12721 gatgtcagtt gaagaatacg caaaatttat gttggaatct aaaatcggaa tctctctaat
    12781 ggcctcaccg catcctagct atcctccgtt agaaatggct acgtttggta tgaaagtcat
    12841 aacgaattct ttcgttacaa aagatatttc tgattttaat gaaaacataa tttctattga
    12901 acatattaat attaataaat tggcggaaga attacatttt ttaacaacat ctgatataga
    12961 atataaaatt tcgaaaaacg atgattatat aaatggtatt agccagcttg atacaattgt
    13021 agatgaaatt gcgggacatt tacaatttcg gcatagcgag gtgtgattgt gaaaaggaaa
    13081 tccattgccc gaaattattt acttaatttg ataaaaacga ccttgtctat tctatttccc
    13141 ctgatatcat acccatatgt gtcgcgtatt ttatctgtgg atgggctggg tgcaatcaat
    13201 ttttcaacct cgtttgttaa ttatttcgta ctaattgcaa tctttggaat taatgtctac
    13261 gctgttagag aaggtgctaa atatcgagat gataaaaagt tacttgggaa gtttgtaacg
    13321 gagatgctac ttgttagtat ttgcatggca atgatttcat tctctttatt aactatttcc
    13381 ttactattac ctgctctatc agaatataga agtcttattc taattttttc aattaccatt
    13441 ctatttaatg ttgtgggaat ggagtggttt tttcaattga tggaagacta tcaatatata
    13501 acacttcgtg caattatatt tcaaatttta tctttgctat ctttattcat atttgtcaaa
    13561 gacaggaatg acatctatgt gtacgctcta attacagttg cggctaatgc aggttctcaa
    13621 atgctgaatt tatttaggct tagaaaagaa gttgaaatat ttagatataa agactataat
    13681 attagacatt attttaaacc gatgtttctg atatttttaa ccttattatc tatgaatata
    13741 tatagatatt tagatgttac ttttctgggc ttctttaaaa atgatcaaag tgtgggctac
    13801 tatagtttag ctacaaaaat aacaaatgtt ataatttcaa tggtatcttc tgttacagtt
    13861 attttgacac ctcgtctagc ataccattat aagcaaaagg agtttgataa attctataaa
    13921 attgcttata gctcctttga ttttatttta ttacttgcta taccagttgt tataggggta
    13981 ttgagtttta gttctatttt agtggatttt ttgggaggaa gtgcttttat ttcttctgtg
    14041 ctaacagtgg agatattaag tttaacaatt ctattctcta atttgaatgc tttattaatt
    14101 acacctattt taacagttat gaatcatgag aaagcggttt taaaaatttt tattatagca
    14161 ttgattttca atgttattgc aaacatgttc cttattccag taatggattt taatggttca
    14221 gctttggtta cagttttgac agaaggaatc atttgcatat tatctttaat tagtataaaa
    14281 aatgtatttg atgttaaaag attatttaag aatctttttc aatatctagt agctagtata
    14341 tttataattg ttgtcaagat tgttatttct cagtacgttt catcaaatta tattattttt
    14401 atttcaactg ctttactaag cgcaatttta tatttcttta ctttgatatt attgagaaat
    14461 gagttagtat cacaattaat aatagaagtc agaaagaaaa tatatagata atggagttaa
    14521 atataaatgt ttaccatata tagagctatg aaaaaaataa ttataatcat tttgtctctt
    14581 cccaagattt tttatataaa tttaaaatgt cttccgttga atcaggcagt taaacttcct
    14641 atatatgttc attttaatac tcgattaatg attaagggag acataaaaat cattgatact
    14701 catttatcac gttttactat cattttggga aaagatggct ctaatcatat ctctcctcat
    14761 gagagtagat tatttattta tgatgggggc caattaattc tagggagaaa tattctatta
    14821 tctagtggat ttaatttgtg tatagagcaa ggaggtacgg ttaaattagg agataatgtc
    14881 tcttttaaca gaaattcttc gatcttttgt aaaaaacaaa ttaatattgg taaaaatagt
    14941 ttatttggtt ggaactgtag tttacgtgat aacaatggac ataggatcta ttatcaggac
    15001 aactgtatta agagtgaaga agttattgta ataggagaga attgctggat aacagcagac
    15061 tcagtcattc ttaaaaatag tgttcttcct ttttctactg tagttgctac aggtagttta
    15121 gtaaacaaag agtttaatca gagtaacatt ttgatagctg gaaggcctgc tagaattatt
    15181 agagaggata taaaatggga aagataagat agtaattgat taactaggtc gtgtaatttt
    15241 taacagagat aacgaaaggt aatgggtgaa gtaaatgaaa attgcggttg caggtacagg
    15301 atatgtagga ctgtctattg cagttttaat ggctcaacat catgaggtgg tagctgttga
    15361 tattatttct gaaaaggtca atctgattaa taatggaaaa tctccaataa aggatgacta
    15421 tattgaagaa tatttagcat caaagcccct caacttagtg gcaacattgg atacaaatat
    15481 agcgtaccaa aatgcagatt ttgtaattat agcagctcca acaaattatg attcagaaaa
    15541 gaattttttt gatacatctg ctgtagaagc agttattgaa acggtgttag agactaatcc
    15601 taacgctgta atggtgatta aaagtactgt tcctgtaggc tatactcaat cgattcgtaa
    15661 taaatataaa acaaataata ttttatttag tccagaattt ttacgtgagt caaaggcttt
    15721 atatgataat ttatatccta gccgtataat tgttgggctt gatatggacg atgcatattt
    15781 aaaggagaga gcagaaactt ttgcagaact actacaagaa ggagctatta aagagaatat
    15841 agaaattctt tacatgggat ttacagaggc agaagcagtc aaactttttg caaatacata
    15901 tttagccttg cgagtttctt atttcaatga gttggatact tatgcagaag ttaaagggtt
    15961 agatactaaa gctattattg aaggtgttgg cttagatcca cgtatcggaa gccaatataa
    16021 caatccttct tttggatatg ggggatattg ccttccaaaa gatagtaaac aactattggc
    16081 aaactataaa gatgttccac agaatatgat aacagctatc gttgagagca accgtactag
    16141 aaaagatttt attgcagagc agattttgaa atttgcagga gtttcaagta atggggaaat
    16201 tcatccaaaa gatgtaataa taggacttta tcggttgact atgaagagta attccgataa
    16261 ttttcgtcaa tcttctattc aaggtgttat gaaacgattg aaggcagaag gcacaaatgt
    16321 tataatttat gagccaactc ttagtgatga tgagacattt ttgggtagta agattgtaaa
    16381 tgatttggag cactttaaat caattagtaa tgttatcgtg gcaaatcgtt atgatgattt
    16441 gcttaaagat gtgagtgaca agatttatag tcgtgatatt tttaagagag attaggtaga
    16501 agttataatg tatgattatt taatcgttgg agctggtttg tctggagcta tttttgctca
    16561 cgaagctaca aaatgtggaa aaaaagtaaa agtgattgat aaacgcgatc acattggagg
    16621 gaacatatac tgtgagaatg tagaaggtat caatgttcat aaatatggtg cccatatctt
    16681 ccatacttct aataaaaaag tctgggacta cgtcaatcaa tttgctgagt ttaacaacta
    16741 tatcaactca cctgtcgcaa actataaggg aagtctttat aaccttcctt tcaatatgaa
    16801 taccttctat gctatgtggg gcacaaaaac tccacaagaa gtgaaggata agattgctga
    16861 gcagacagct ggtatgaagg atgttgagcc gaaaaatctg gaagaacaag ctatcaagtt
    16921 gattggtccg gatatctatg aaaagttgat caagggttat acagaaaagc aatggggacg
    16981 ctcagcgaca gaacttcctc catttatcat aaaacgcctt ccagttcgtt taacctttga
    17041 taataactat tttaatgacc gttaccaagg gattcctatt ggtggttaca atgtcatcat
    17101 cgaaaatatg ctgaaagatg tagaagttga acttggagta gacttttttg ctcatcgtga
    17161 agagttggaa gcatctgcta acaaagttgt cttcacagga atgatcgacc aatattttga
    17221 ctacaagcac ggagagttag aataccgtag ccttcgtttt gagcatgaga ttttagacga
    17281 ggaaaattat caagggaatg ctgtagtgaa ctatacagag cgtgagatcc cttatactcg
    17341 tatcatcgaa cacaaacatt ttgaatatgg aatgcagcca aagacagtta tcacgcatga
    17401 atatccagct gactggaagc gtggggacga gccctactat cctattaacg atgagaaaaa
    17461 taatgctatg tttgctaaat accaagaaga agcagcgcag aatgataaag ttatcttttg
    17521 tgggcgttta gcagactata aatattacga tatgcatgtg gtgattgaac gggcgcttga
    17581 ggttgtggag aaagaattta gtaattgaaa aacaacgaag aaaggttgct tatatatgaa
    17641 aggtattatt cttgcaggtg gttcggggac acgattatat cctttgactc gggctgcatc
    17701 aaaacaactt atgccggttt atgataaacc catgatttac tatcctttgt caaccctgat
    17761 gttgactgga ataaaggaca ttttgattat ctcaacacca caggatttgc cccgttttaa
    17821 ggacttgctc ttggatggtt ccgaatttgg gatcaagctt tcctatgcgg aacaacctag
    17881 tcccgatgga cttgctcagg cttttattat cggtgaagag tttatcggtg acgatagcgt
    17941 tgccttgatt ttaggtgaca atatctacca tggtcctggt ctgagcacaa tgcttcaaaa
    18001 agcagccaag aaagagaaag gtgcgactgt ttttggctac caagtgaagg atccagagcg
    18061 ttttggtgtg gttgagtttg atacagacat gaatgctatt tctatcgaag aaaagccaga
    18121 gcaccctcgt tcaaactatg cagttacagg actctatttc tatgataatg atgtagtaga
    18181 gattgccaaa agtataaaac caagccctcg tggtgaactg gaaattacag atgtaaacaa
    18241 ggcttaccta ggtcgtggag atttatccgt tgaggttatg ggacgaggct ttgcttggct
    18301 ggatactgga actcatgaaa gtttattaga ggcttcgcag tacatcgaaa cagtccaacg
    18361 gatgcaaaat gttcaggtag caaacttaga agaaattgcc tatcgcatgg gttatatcag
    18421 tcgtgaagat gtattgacct tagcccaacc acttaagaaa aatgaatacg gacagtatct
    18481 gctccgtttg attggagaag catagatgac agataatttt ttcggtaaga cgcttgcggc
    18541 acgcaaggtt gaagctattc caggcatgtt ggagtttgat atccccgttc atggagataa
    18601 tcgtggctgg tttaaagaaa atttccaaaa ggaaaaaatg cttccacttg gatttccaga
    18661 gtctttcttt gcagaaggaa aattgcaaaa caatgtatcc ttctcacgta aaaatgtcct
    18721 tcgagggctc cacgcagagc cttgggataa gtacatctct gtagcagatg gagggaaagt
    18781 tctgggttct tgggttgatc tacgcgaggg tgaaaccttt gggaatacct atcagacagt
    18841 aattgatgca agcaagggaa tctttgttcc tcgaggcgta gctaatggct tccaagttct
    18901 atcagataca gtgtcatata gctatctggt caatgattac tgggctctcg agctcaaacc
    18961 caagtatgcc tttgtgaact acgctgatcc aagccttggt attgaatggg aaaatattgc
    19021 agaagcagag gtttcagaag cagataaaca tcatccccta cttaaggatg taaaaccttt
    19081 gaaaaaagaa gatttggaat aaggaaagaa tatgactgaa tacaaaaata ttatcgtgac
    19141 aggtggagct ggctttatcg gttctaactt tgtccattat gtttacgaga actttccagg
    19201 tgttcacgtg acagtcctag ataagttgac ttatgctgga aatcgcgcga atattgagga
    19261 aattttaggt aatcgtgttg agttagttgt tggtggcatt gctgatgcgg agttggtaga
    19321 caagttggct gctcaagcag atgctatcgt tcattatgca gcggaaagcc acaatgataa
    19381 ttcgctcaat gatccatcgc catttattca tactaacttc atcggaacct atactctttt
    19441 agaagctgct cgtaagtatg atattcgctt ccaccatgta tcgacagatg aagtttatgg
    19501 ggatctccct ttacgcgaag atttgccagg tcatggtgaa ggaccaggtg agaaatttac
    19561 tgctgaaaca aaatacaacc caagctctcc gtactcatca accaaggcag cctcagattt
    19621 gattgtcaaa gcctgggtgc gttcttttgg agtcaaggca acgatttcca actgttcaaa
    19681 taactacggt ccttatcaac atatcgaaaa attcatccca cgtcagatta ctaacatcct
    19741 aagtggaatt aagccaaaac tttacggtga aggtaagaat gttcgtgact ggattcatac
    19801 caatgaccat tcttcaggag tttggacaat cttgacaaaa gggcaaatcg gtgaaaccta
    19861 cttgattggg gctgatggtg agaagaacaa taaggaagtt ttggaactta tccttaagga
    19921 aatgggacaa gctacggatg cctatgatca tgtgactgac cgtgcaggac atgaccttcg
    19981 ctatgcgatt gatgccagca agctccgtga tgagttgggg tggaaacctg aatttaccaa
    20041 ctttgaagct gggctcaagg caacaatcaa gtggtataca gataaccaag aatggtggaa
    20101 agcagaaaaa gaagctgttg aagccaatta tgctaagact caggagatta ttacagtata
    20161 aaaagcagct atttcctgct ttttattgct atattgggaa gagttacata ttagaaaggt
    20221 ctagagatga ttttaattac aggggcaaat ggccaattag gaacggaact tcgctattta
    20281 ttggatgaac gtaatgaaga atacgtggca gtagatgtgg ctgagatgga cattaccaat
    20341 gaagaaatgg ttgagaaagt ttttgaagag gtgaaaccga ctttagtcta ccattgtgca
    20401 gcctacaccg ctgttgatgc agcagaggat gaaggaaaag agttggactt cgccatcaat
    20461 gtgacgggga caaaaaatgt cgcaaaagca tctgaaaagc atggtgcaac tctagtttat
    20521 atttctacgg actatgtctt tgacggtaag aaaccagttg gacaagagtg ggaagttgat
    20581 gaccgaccag atccacagac agaatatgga cgcactaagc gtatggggga agagttagtt
    20641 gagaagcatg tgtctaattt ctatattatc cgtactgcct gggtatttgg aaattatggc
    20701 aaaaacttcg tttttaccat gcaaaatctt gcgaaaactc ataagacttt aacagttgta
    20761 aatgaccagt acggtcgtcc gacttggact cgtaccttgg ctgcgttcat gacctaccta
    20821 gctgaaaatc gtaaggaatt tggttattat catttgtcaa atgatgcgac agaagacaca
    20881 acatggtatg attttgcagt tgaaattttg aaagatacag atgtcgaagt caagccagta
    20941 gattccagtc aatttccagc caaagctaaa cgtccgctaa actcaacgat gagcctggcc
    21001 aaagccaaag ctactggatt tgttattcca acttggcaag atgcattgca agaattttac
    21061 aaacaagaag tgagataagt agtagaatga ttttctagtc taataaaaga ggcagagaat
    21121 gaactccaaa ggagcttaag atgtacgatt atcttgttgt tggtgcagtc tttgcccatg
    21181 aagcagtctt aaaaggaaaa aaagtaaaag ttattgaaaa atgaaatcat atcgcgggta
    21241 atatctatac tcgtgaagag gaaggaattc aagttcatca atatggtgct catatcttcc
    21301 atacttctga taaggagatc tgggattatg taaatcagtt tgcagagttt aaccgttata
    21361 ccaattctcc tgttgcaaac tataagggag agatttataa cttacctttt aatatgaata
    21421 ccttcaataa actctgggga gttgtgacgc cagcagaagc acaagctaag attgatgaac
    21481 aacgtgctat tttaaatggt aaaactcctg aaaatttgga agaacaggcg atttctcttg
    21541 taggtacaga catctacgaa aaattaatca aagactatac agagaaacag tggggcaaac
    21601 caactactga acttccatcc tttattattc gccgtttacc agtacacctg acctatgata
    21661 acaactattt taacgatacc tatcaaggga ttccaattgg tggatacact caaatagttg
    21721 aaaaatgttg gatcatgaaa atattgatgt agaaacaaat gttgatttct ttgtgaacaa
    21781 agagcaatat ctgaaagatt ttcctaagat tgtctttact ggtatgattg atgaattctt
    21841 tgactataag ttgggcgaac tagagtaccg tagtcttcgt tttgaaaatg agaccttgga
    21901 tatggaaaat taccaaggaa atgcagttgt gaactatacg gatgcagaaa ccccatatac
    21961 tcgcattatt gaacacaaac attttgagtt tgggagtcaa gcaaagacta tcattactaa
    22021 tagaacattc taaaacatgg gaaaaaggtg atgagcctta ttatccagtt aataatgatc
    22081 gtaataatga tcgtaataat catttgtata aatcatataa aaaacttgct gatgagcaag
    22141 ggaatgttat ctttggtggc cgcttaggac actatcgtta ttacgatatg caccaagtaa
    22201 ttggagcagc tttgcagtgc gtgagaaatg agttagattc atactcaatg aaaattaaag
    22261 agcaaactag gaagctagcc gcaggttgct caaaacactg ttttgaggtt gcagatggaa
    22321 gctgacgcgg tttgaagaga ttttcgaaga gtataaacaa gtaaaactga ctaccagtta
    22381 ttatttagaa atagtattaa aaattccttg actatatgat atagttgagg gatttttaaa
    22441 tgatattcat attttttgca aagatgttgt ttgaaaaata attttcaaaa attctgaaaa
    22501 ttctgttgac aactttctga aaagagtcta taatggagag aaagtttaaa aggagaaaat
    22561 gatgaaaagt tcaaaactat ttgcccttgc gggcgtgaca ttattggcgg cgactacttt
    22621 agctgcatgc tctggatcag gttcaagcac taaaggtgag aagacattct catacattta
    22681 tgagacagac cctgataacc tcaactattt gacaactgct aaggctgcga cagcaaatat
    22741 taccagtaac gtggttgatg gtttgctaga aaatgatcgc tacgggaact ttgtgccgtc
    22801 tatggctgag gattggtctg tatccaagga tggattgact tacacttata ctatccgtaa
    22861 ggatgcaaaa tggtatactt ctgaagggga agaatacgcg gcagtcaaag ctcaaga
//
