LOCUS       CR931715               19403 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 198/71 (serotype 42).
ACCESSION   CR931715
VERSION     CR931715.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19403)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 19403)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..19403
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="198/71"
                     /db_xref="taxon:1313"
     gene            <1..33
                     /gene="dexB"
                     /locus_tag="SPC42_0001"
     CDS             <1..33
                     /gene="dexB"
                     /locus_tag="SPC42_0001"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34510.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZU9"
                     /translation="PWDAFCVELL"
     gene            192..360
                     /gene="aliB"
                     /locus_tag="SPC42_0002"
                     /pseudo
     CDS             192..360
                     /gene="aliB"
                     /locus_tag="SPC42_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(378..893,895..1221))
                     /gene="tnp"
                     /locus_tag="SPC42_0003"
                     /pseudo
     CDS             complement(join(378..893,895..1221))
                     /gene="tnp"
                     /locus_tag="SPC42_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(join(831..893,895..1203))
                     /gene="tnp"
                     /locus_tag="SPC42_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 1.4e-21"
                     /pseudo
     gene            1428..2882
                     /gene="wzg"
                     /locus_tag="SPC42_0004"
     CDS             1428..2882
                     /gene="wzg"
                     /locus_tag="SPC42_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI34513.1"
                     /db_xref="GOA:Q4JYW1"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW1"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLLFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     EAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGIDVY
                     NDQEFTAHTNGKYYPAGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1428..1553
                     /gene="wzg"
                     /locus_tag="SPC42_0004"
                     /note="Signal peptide predicted for SPC1883 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 42 and 43"
     misc_feature    1641..1988
                     /gene="wzg"
                     /locus_tag="SPC42_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 8.6e-63"
     misc_feature    2166..2609
                     /gene="wzg"
                     /locus_tag="SPC42_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 2.5e-69"
     gene            2884..3615
                     /gene="wzh"
                     /locus_tag="SPC42_0005"
     CDS             2884..3615
                     /gene="wzh"
                     /locus_tag="SPC42_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI34514.1"
                     /db_xref="GOA:Q4JYW0"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JYW0"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLTESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGEPDKFMKKRAQYFLERDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    2887..3495
                     /gene="wzh"
                     /locus_tag="SPC42_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.6e-37"
     gene            3621..4316
                     /gene="wzd"
                     /locus_tag="SPC42_0006"
     CDS             3621..4316
                     /gene="wzd"
                     /locus_tag="SPC42_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI34515.1"
                     /db_xref="GOA:O86887"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:O86887"
                     /translation="MMKEQNTIEIDVFQLFKTLWKRKLMILIVALVTGAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGSYLVKDYREIILSQDALEKVATNLKL
                     DMPAKTLASKVQVTVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLKI
                     PLLGLVPDFDKIK"
     misc_feature    3621..3737
                     /gene="wzd"
                     /locus_tag="SPC42_0006"
                     /note="Signal peptide predicted for SPC1885 by SignalP 2.0
                     HMM (Signal peptide probability 0.625) with cleavage site
                     probability 0.411 between residues 39 and 40"
     misc_feature    3642..4058
                     /gene="wzd"
                     /locus_tag="SPC42_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 3.1e-55"
     misc_feature    4164..4241
                     /gene="wzd"
                     /locus_tag="SPC42_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4326..5015
                     /gene="wze"
                     /locus_tag="SPC42_0007"
     CDS             4326..5015
                     /gene="wze"
                     /locus_tag="SPC42_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI34516.1"
                     /db_xref="GOA:Q4JZK1"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4JZK1"
                     /translation="MPTLEISQAKLDSVKKAEEYYNALCTNLQLSGDGLKVFSITSVK
                     IGEGKSTTSANIAWAFARAGYKTLLIDGDIRNSVMLGVFKARNKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFTTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRNCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGIVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            5030..6397
                     /gene="wchA"
                     /locus_tag="SPC42_0008"
     CDS             5030..6397
                     /gene="wchA"
                     /locus_tag="SPC42_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34517.1"
                     /db_xref="GOA:Q4JYV7"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV7"
                     /translation="MNGKILRSSLAIIQSFLVILLTYLLSAVRETEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRRYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYWKRAYLNFKGSKKILLLTATSRVEKVLDRLIESNEVVGKL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHIMAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVLM
                     KDGAK"
     misc_feature    5030..5116
                     /gene="wchA"
                     /locus_tag="SPC42_0008"
                     /note="Signal peptide predicted for SPC1887 by SignalP 2.0
                     HMM (Signal peptide probability 0.844) with cleavage site
                     probability 0.429 between residues 29 and 30"
     misc_feature    5813..6394
                     /gene="wchA"
                     /locus_tag="SPC42_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 4.8e-158"
     gene            6384..7190
                     /gene="wciB"
                     /locus_tag="SPC42_0009"
     CDS             6384..7190
                     /gene="wciB"
                     /locus_tag="SPC42_0009"
                     /note="member of homology group 16"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34518.1"
                     /db_xref="GOA:Q4JZB6"
                     /db_xref="UniProtKB/TrEMBL:Q4JZB6"
                     /translation="MERSRLIDVKIIVATHKEVKMPQDNSLYLPIHVGRDGKSDIGFI
                     GDNTGDNISSLNPYYCELTGLYWAWKNLDYNYLGLVHYRRYFTNKSQGYNENVNMDDV
                     ILSRSNVEILLEKSDVIVPKKRKYYIETLYSHYAHTLNGEHLDLARKIIEQNSSEYLS
                     SFDKVMKQRSGYMFNMFIMKKGLLDDYLPWLFSILDTMYEQMDLTDYTSFESRLFGRV
                     SELLFNVWLCKKGITPKEVPFMYMERVDLFEKGKSFLMAKFFGKKYGQSF"
     gene            7199..8392
                     /gene="wzy"
                     /locus_tag="SPC42_0010"
     CDS             7199..8392
                     /gene="wzy"
                     /locus_tag="SPC42_0010"
                     /note="member of homology group 45"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI34519.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV5"
                     /translation="MKITIKRYSLPEILGLAALAIFLLFSLLSITLYAQYISIKVYFI
                     ALFGIILLIFLKELISESYNLKSVIGLFVIFTLCFIIGTVTNYAYFFILGLFLIYSLR
                     NLPFSDVAKVSFIISISVLLLVVLSSKLGIIPDYIEISPTRVRHYLGFRYSLLPSTLM
                     MNIIAISFFLKQENASYPRLLVLFLLSGWLYVETDSRLTFINSCLFLLVNLIMKLSPS
                     IIEKVGRLLKLFSFTYFINACLSYWIAKTYLNTSNVVLNQFFYQADQFLGGRIYYSNR
                     SLSLYGYKLLGQKIDWIGNGLSIQGERSTETYLYVDNLYIQILQHFGLIVSVIILSLL
                     TITLVKLLKKGQMVLGIILVILSFHALIDDLILNLYYNIFWVLIGMLIYKKYQFYDKK
                     QLTIE"
     misc_feature    7199..7300
                     /gene="wzy"
                     /locus_tag="SPC42_0010"
                     /note="Signal peptide predicted for SPC1889 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.778 between residues 34 and 35"
     gene            8547..9542
                     /gene="wcrI"
                     /locus_tag="SPC42_0011"
     CDS             8547..9542
                     /gene="wcrI"
                     /locus_tag="SPC42_0011"
                     /note="member of homology group 128"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34520.1"
                     /db_xref="GOA:Q4JYV4"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV4"
                     /translation="MNKINLTDNLPLISVVLPVYNVENYLEKCLNSVVRQTYKNIEII
                     IVNDGSLDSSIDICNKYANKDSRIKVFTKPNGGLSDARNFGVKKSMGEFITFVDSDDY
                     VTDDYVEYLYSLVKKYNCKMSMCSIFVHYISNDKMINNGTGRELMMTAERCIEKMCYH
                     DEVDTCAYAKLYHRSLFSEICFPKGRIFEDIGTIYRFFGTAGQIACGFNAKYYYEIRE
                     NSIVTSSFSEKKFDLLFMTDQMRNFVDQRYPSLKAATKRRAVYARFSTLNQLLDVQGY
                     NEEKKEIIRFIQDNKEALLENPKTPKRDRLAVRALSLGFCIYKLLWKQYLKIQRG"
     misc_feature    8586..9089
                     /gene="wcrI"
                     /locus_tag="SPC42_0011"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 6.1e-48"
     gene            9544..10695
                     /gene="wcrJ"
                     /locus_tag="SPC42_0012"
     CDS             9544..10695
                     /gene="wcrJ"
                     /locus_tag="SPC42_0012"
                     /note="member of homology group 129"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glycerol phosphotransferase"
                     /protein_id="CAI34521.1"
                     /db_xref="GOA:Q4JYV3"
                     /db_xref="InterPro:IPR007554"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV3"
                     /translation="MNKEFLKYIYIRLLRNLRRIFFIIPIIRNRVVFESFSGDAYSCN
                     PKYISEELRKQYGDSVEIIWAFNDPNKFKKELPKEIVTCRYRSFNHLIYRITSKVYVC
                     NFLQAIEIPKRKGQLEIQTWHGGGCYKKVGVAEKGRQAAYVKRQRMHVEETDLFITSS
                     KYFENEVVKKQFGYKGEILSIGMPRNDILINLPISSQVEKLKEKLGLPNNKLIALYAP
                     TWRSGTKQYETLDIKKLTQAVDKKFGKKCIVLFRSHLYGNQSYDDVVDVSQYSDMQEL
                     LLLSDILITDYSSSMWDFSLSFKPCFLYTPDLKDYLDERGFDEDIHSWGFSVSESNKE
                     LVENILQFDNEEYRQKMKNHHQFLESYEQGDAAKRVVAKIAEYCNLYRG"
     misc_feature    10144..10671
                     /gene="wcrJ"
                     /locus_tag="SPC42_0012"
                     /note="HMMPfam hit to PF04464,
                     CDP-Glycerol:Poly(glycerophosphate) gl, score 5.1e-37"
     gene            10699..11604
                     /gene="wcrK"
                     /locus_tag="SPC42_0013"
     CDS             10699..11604
                     /gene="wcrK"
                     /locus_tag="SPC42_0013"
                     /note="member of homology group 130"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34522.1"
                     /db_xref="GOA:Q4JYV2"
                     /db_xref="InterPro:IPR008441"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV2"
                     /translation="MKKIAYLIKRYGVKNVVLRAINDVLPVNLIFPSQQLRRLNWQEK
                     VKKKLKKYVVISDSIKSEEECDIIWWLWFQGLDNAPAIVKKCRESVDKYAKRSGKRVI
                     ELTSQNLFEYIEVPNELYVKYKSGSLPLALFSDFCRISLLSNYGGLWIDSTVLITGEI
                     EDEILNQDIFMFQASPLDYSVTKISNWMLYSKYPGHPFISSIRDTLISFYNKNNTIPD
                     YFLFHLLVSCLIDDNRINQSFYDMDYYTNTYPHLLGRVLSEPYDTLKFENILRKTSIH
                     KLSYKNLDNVAEDSFYNAILGLDFS"
     misc_feature    10753..11583
                     /gene="wcrK"
                     /locus_tag="SPC42_0013"
                     /note="HMMPfam hit to PF05704, Capsular polysaccharide
                     synthesis protein, score 4.7e-51"
     gene            11622..12338
                     /gene="mnp1"
                     /locus_tag="SPC42_0014"
     CDS             11622..12338
                     /gene="mnp1"
                     /locus_tag="SPC42_0014"
                     /note="member of homology group 131"
                     /codon_start=1
                     /transl_table=11
                     /product="putative IspD-family transferase (mannitol)"
                     /protein_id="CAI34523.1"
                     /db_xref="GOA:Q4JYV1"
                     /db_xref="InterPro:IPR001228"
                     /db_xref="InterPro:IPR018294"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV1"
                     /translation="MNLAVIFAGGSGTRMNAKDRPKQFLLVHGKPIIVHTIELFENHP
                     EIDGIIVVCIEDWIPYMEEMKYCYRLDKIAKIVPGGATGQLSIYNGLVAAEQLYGIED
                     NVVLIHDGVRPLITADTISDNIQSVKEKGNAITCTVAKETVILVDDENKVDEVPSREH
                     SRFAKAPQSFWLKDILGAHRASVDNGRNNFIDSCTMMRYYGHDLHVVVGPYENIKITT
                     PDDFYTFRALYDLRENKQLK"
     misc_feature    11628..12317
                     /gene="mnp1"
                     /locus_tag="SPC42_0014"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 6.5e-05"
     misc_feature    11628..12320
                     /gene="mnp1"
                     /locus_tag="SPC42_0014"
                     /note="HMMPfam hit to PF01128, Uncharacterized protein
                     family UPF000, score 3.9e-23"
     gene            12349..13419
                     /gene="wcrH"
                     /locus_tag="SPC42_0015"
     CDS             12349..13419
                     /gene="wcrH"
                     /locus_tag="SPC42_0015"
                     /note="member of homology group 51"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34524.1"
                     /db_xref="GOA:Q4JYV0"
                     /db_xref="InterPro:IPR016503"
                     /db_xref="UniProtKB/TrEMBL:Q4JYV0"
                     /translation="MKYFVEETLLDEQDKKNAGGKARQDVTDILESIGYQKLIAESEM
                     NERQELNAVQRLVHHYKVKKMWKKTLSVVGKGDEVIIQFPLLNHSLFFNQVIKQLSKN
                     GVKVYFLIHDLESLRWSQSKSISLKSRIRLNIEEHSVLRLSEGIIAHNKKMKSYIKTY
                     SVESSKIIPLETFDYIIPSYHERKNLDNFQLNAPIVIAGNLKQHKAGYVYHLPSNVEF
                     NLYGIGYEQTDDKSVHYCGSFMPEELPFVLKGSFGLVWDGPSSESCIETYGEYLRVNN
                     PHKTSLYLASGIPVVVWSEAAIASFIKENNCGILVSNLSELPELLSMITVDEYELMKK
                     NTEIIGERLRQGFYTKQAVKGF"
     gene            13435..14514
                     /gene="mnp2"
                     /locus_tag="SPC42_0016"
     CDS             13435..14514
                     /gene="mnp2"
                     /locus_tag="SPC42_0016"
                     /note="member of homology group 132"
                     /codon_start=1
                     /transl_table=11
                     /product="putative dehydratase/epimerase (mannitol)"
                     /protein_id="CAI34525.1"
                     /db_xref="GOA:Q4JZA9"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JZA9"
                     /translation="MIESFNDKVLQEDLEIIAKEELPFRKFRNSTVFITGVTGLVGLQ
                     LFKALACINRVHQLNMKIIGLVRNLDKAEKIFGDLLKRKDIQIVLGDVSEDFHSYIPD
                     GLVIDYIIHGASVTTSKLMIEFPVDTIRVAFNGTYQMLELAKEKKVKSFVYLSSMEVY
                     GSFQSDRTTVVNENMLGYLDLTSVRTNYPECKRICENMCIAFLSQYQVPAKIARLSQT
                     FGAGTLPGENRVFAQFARSVMQGKDIVLHTLGQSEGNYCYTADTVVALLTILLRGENG
                     EAYNIANEESHTTIADMAKMVTSQFSQTSQVVFDIPKKNIFGYAVDTKMKLSTHKIQQ
                     LGWKPRVSLVDAYDRMMRSMNETGV"
     misc_feature    13528..14280
                     /gene="mnp2"
                     /locus_tag="SPC42_0016"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 9.2e-23"
     misc_feature    13531..14373
                     /gene="mnp2"
                     /locus_tag="SPC42_0016"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 0.00013"
     gene            14523..15938
                     /gene="wzx"
                     /locus_tag="SPC42_0017"
     CDS             14523..15938
                     /gene="wzx"
                     /locus_tag="SPC42_0017"
                     /note="member of homology group 7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI34526.1"
                     /db_xref="GOA:Q4JZA8"
                     /db_xref="InterPro:IPR002528"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4JZA8"
                     /translation="MKVLKNYLYNLSYQLLVIILPIITTPYVTRIFSSDDLGTYGYFN
                     SIVTYFILLATLGIANYGTKEISGNRKSIQKNFWGIYTLQFGATTFSIFLYILACLFI
                     PGMKNLVAYILGLGLVSKGLDISWLFQGLEDFRKITVRNITVKLVGVSAIFLFVKSAS
                     DLYLYVFLLTAFELLGQLSMWFPAREYIGKPHFDIEYARHHLKPVILLFLPQIAISLY
                     VTLDRTMLGALASTKDVGIYDQALKLVNILLTLVTSLGSVMLPRVAHLLATGDHKVVN
                     KMHEVSFLIYNLVIFPIMAGMLIVNDDFVQFFLGQDFQDARYAISIMIFRMFFIGWTN
                     IMGIQILIPHNQNKEFMISTTTPAIISVGLNLLFLPKLGYIGAAIVSVLTEALVWAIQ
                     LFYTRRYLKEVPIIGSMSKIILASAIMYGLLLSSKTVIHFSPTLNVLAFVALGGIIYL
                     FAILSLKVVDVKELKQIIRKN"
     misc_feature    14529..15323
                     /gene="wzx"
                     /locus_tag="SPC42_0017"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 1.5e-65"
     gene            15940..16938
                     /gene="wciG"
                     /locus_tag="SPC42_0018"
     CDS             15940..16938
                     /gene="wciG"
                     /locus_tag="SPC42_0018"
                     /note="member of homology group 21"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase"
                     /protein_id="CAI34527.1"
                     /db_xref="GOA:Q4JYU7"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:Q4JYU7"
                     /translation="MRKNRNINLDLLKVLACVGVVLLHTTMGGFKETGSWNLLAYLYY
                     LGTYSIPLFFMINGYLLLGKREITYLYILQKVKWILITVSSWSFIVWLFKRDFTTNPI
                     KKIVGSLIQRGYFFQFWFFGALILIYLCLPILRQFLNSKRSYLYSLSLLMTIGLIFEL
                     SNILLQMPIQTYVIQTFRLWTWFFYYLLGGYIAQFTIEEIESRFKNWMKIVSILLLLI
                     SPIILFFIAKTIYHNLFAEYFYDTLFVKVSTLGIFLTILMLTLNENRRESIVSLSNQT
                     MGVFIIHTYIMKVWEKVLGFNFVGAYLLFALFTLSVSFIIVGMLMKIPYFNRIVKL"
     gene            16952..18061
                     /gene="glf"
                     /locus_tag="SPC42_0019"
     CDS             16952..18061
                     /gene="glf"
                     /locus_tag="SPC42_0019"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI34528.1"
                     /db_xref="GOA:Q4JYU6"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYU6"
                     /translation="MYDYLIVGAGLSGAIFAYEATKRGKKVKVIDKRNHIGGNIYCEN
                     VEGVNVHKYGAHIFHTSNKKVWDYVNQFAEFNNYVNSPVANYKGSLYNLPFNMNTFYA
                     MWGTKTPQEVKDKITEQTADMKDVEPKNLEEQAIKLIGPDVYEKLIKGYTEKQWGRSA
                     TELPPFIIKRLPVRLTFDNNYFNDRYQGIPIGGYNVIIENMLKDVEVELGVDFFAHRE
                     ELEASAEKVVFTGMIDQYFDYKHGELEYRSLRFDHEILDEENYQGNAVVNYTEREIPY
                     TRIIEHKHFEYGTQAKTVITREYPADWKRGDEPYYPINDEKNNAMFAKYQEEASKNDK
                     VIFCGRLADYKYYDMHVVIERALEVVEKEFGYDKK"
     misc_feature    17387..17989
                     /gene="glf"
                     /locus_tag="SPC42_0019"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 1.2e-137"
     gene            18042..19076
                     /gene="wcjE"
                     /locus_tag="SPC42_0020"
     CDS             18042..19076
                     /gene="wcjE"
                     /locus_tag="SPC42_0020"
                     /note="member of homology group 18"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase"
                     /protein_id="CAI34529.1"
                     /db_xref="GOA:Q4JYU5"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:Q4JYU5"
                     /translation="MDMTKSRINWIDFGKGFSIFLVLAGHVLLGLYQSEKFPTANNIL
                     SLLIAQVYIFHIPVFFALSGYFFKPVSDLKEFWQYAKKKTIVFGLPYIFYSIIHFGLQ
                     KVAGASVRVPTTISDLLNIYKHPLGVSWYLYILWSILIIYGLLSILVKNRRMLFLISV
                     FAYCLTLFVQTDIYIIQRTLVWGICFFLGSVLSEIHFDKINLKKFLFFFVLFDFIYMF
                     AWFLFYEVGSKKDYVSYINPGLWGIAFIVCVLVAFAIFPKMEKNFPKTFLYFTKYGKD
                     SLGIYILHAPICSMIRILMLKVGINSVFLHVVVGIVLGWYLSILATYILKKIPFLNIV
                     LLPQKYIKLK"
     gene            19251..>19403
                     /gene="aliA"
                     /locus_tag="SPC42_0021"
     CDS             19251..>19403
                     /gene="aliA"
                     /locus_tag="SPC42_0021"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34530.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K0S2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYL"
     misc_feature    19251..19337
                     /gene="aliA"
                     /locus_tag="SPC42_0021"
                     /note="Signal peptide predicted for SPC1900 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
BASE COUNT     6220 a   2851 c   3844 g   6488 t
ORIGIN
        1 ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa atttaaaatt
       61 gaaatcgtat aaaaacaagg gaggactgta taaaagacag aaatcctttg ttttttataa
      121 ccaaggttta taaactttca ttctcgaaat tcaattaact ttacaaattc ccactattaa
      181 ggagaaagaa gatgaacata aagaagcgtg tccttagtgc aggcctgact tttgcatctg
      241 ctttgctttt agctgcttgc ggccaatcag gttcagatac aaaaacttac tcagcaacct
      301 ttagtggaaa tccaactaca tttaactatc tattagacta ttacgctgat aatatagtca
      361 attgaaacaa gaacaagaca aaagcagctc aaaaaggtat tgcaacttgg taataccttt
      421 ttgaggttct ttttgatata agcccatgtt ttctcaatag gattgtactc aggtgagtag
      481 ggaggaagag gtaaaagttt atgcccaaac tcctcgcata aaagttctaa cttacccatt
      541 ctatggaatc ttgcattatc cataataata accgatggtg tggttaatgt tggtaagaga
      601 aacttctgaa accaagcttc aaaaaagtcg ctcgtcacca tctcttcgta agtcattgga
      661 gcgattaact caccatttgt tagacctgca accaaagaaa tcctctgata tcttcttcca
      721 gatactttac ctcttattaa ctgacctttt aatgagcgac catattctcg ataaaaataa
      781 gtatcgaatc ctgtttcatc aatctaaaca ggtgctaggt gctttaaact attaaaattt
      841 ttaagaaata aggctacttt ttctgggtct tgttcatagt aggtgtggtt ctttttttcg
      901 agtgtagccc atagctttga gcgcatagtg gatggtagtt ggatgacagg caaattcaga
      961 agctatttca gtcaaataag cgtctggatt gtcagtaaga tagtttttaa gtctatctct
     1021 atcaaccttt cttggttttg ttccttttac ttggtggttt agctctcctg ttttctcttt
     1081 tagctttaac cagccataaa tggtattacg tgagatttgg aaaacgtgtg acgcttctgt
     1141 tatactacct gttcgctcac aataagagag aactttttta cgaaaatcta ttgaatatgc
     1201 cataaaaaga ttataccaca ttgtgtacta tattagattg aaactagaat agtacacatc
     1261 tgcttctaaa acattgttag aaatcgattt gactgtcctt atttcatttt attatatttt
     1321 tggttcgcgg gaagtctact aagatactta aagatgcaga tagtgaaaat aaaggtgtag
     1381 acattaccgt aaaaaagtga tataatcgta tgatgttcaa tgtataggtg ttaatcatga
     1441 gtagacgttt taaaaaatca cgttcacaga aagtgaagcg aagtgttaat atagttttgc
     1501 tgactattta tttattgtta gtttgttttt tattgttctt aatctttaag tacaatatcc
     1561 ttgcttttag atatcttaat ctagtggtaa ctgcgttagt cctactagtt gccttggtag
     1621 ggctactctt gattatctat aaaaaagctg aaaaatttac tatttttctg ttgctgttct
     1681 ctatccttgt cagctctgtg tcgctctttg cagtacagca gtttgttgga ctgaccaatc
     1741 gtttaaatgc gacttctaat tactcagaat attcaatcag tgtcgctgtt ttagcagata
     1801 gtgatatcga aaatgttacg caactgacga gtgtgacagc accgactggg actgataatg
     1861 aaaatattca aaaactacta gctgatatca agtcaagtca gaataccgat ttgacggtca
     1921 accagagttc gtcttacttg gcagcttaca agagtttgat tgcaggggag actaaggcca
     1981 ttgtcctaaa tagtgtcttt gaaaatatca tcgagtcaga gtatccagac tacgcatcga
     2041 agataaaaaa gatttatacc aagggattca ctaaaaaagt agaagctcct aagacgtcta
     2101 agaatcagtc tttcaatatc tatgttagtg gaattgacac ctatggccct attagttcgg
     2161 tgtcgcgatc agatgtcaat atcctgatga ctgtcaatcg agataccaag aaaatcctct
     2221 tgaccacaac gccacgtgat gcctatgtac caatcgcaga tggtggaaat aatcaaaaag
     2281 ataaattaac ccatgcgggc atttatggag ttgattcgtc cattcacacc ttagaaaatc
     2341 tctatggagt ggatatcaat tactatgtgc gattgaactt cacttcgttt ttgaaattga
     2401 ttgatttgtt gggtggaatt gatgtttata atgatcaaga atttactgcc catacgaatg
     2461 gaaagtatta ccctgcaggc aatgttcatc ttgattcaga acaggctctc ggttttgttc
     2521 gtgagcgcta ctcactagca gatggcgatc gtgaccgcgg gcgcaatcaa caaaaggtga
     2581 ttgtggctat ccttcaaaaa ttaacgtcaa ccgaagcact gaaaaattat agcacgatca
     2641 ttaatagctt gcaagattct atccaaacaa atatgccact tgagactatg ataaatttgg
     2701 tcaatgctca gttagaaagt ggagggaatt ataaagtaaa ttctcaagat ttaaaaggta
     2761 caggtcggac ggatcttcct tcttatgcaa tgccagacag taacctctat gtgatggaaa
     2821 tagatgatag tagtttagct gtagttaaag cagctataca ggatgtgatg gagggtagat
     2881 gaaatgatag acatccattc gcatatcgtt tttgatgtag atgacggtcc caagtcaaga
     2941 gaggaaagca aggctctctt gacagaatcc tacaggcagg gggtgagaac cattgtctct
     3001 acctctcacc gtcgcaaggg catgtttgaa actccggaag agaagatagc agaaaacttt
     3061 cttcaggttc gggaaatagc taaggaagtg gcgagtgact tggtcattgc ttacggggct
     3121 gaaatttact acacaccaga tgttctggat aagctggaaa aaaagcggat tccgaccctc
     3181 aatgatagtc gttatgcctt gatagagttc agtatgaaca ctccttatcg cgatattcat
     3241 agcgccttga gcaagatctt gatgttggga attactccag tcattgccca cattgagcgc
     3301 tatgatgctc ttgaaaataa tgaaaaacgc gttcgagagc tgatcgatat gggctgttac
     3361 acgcaagtaa atagttcaca tgtcctcaaa cccaaacttt ttggagaacc tgataaattc
     3421 atgaaaaaaa gagcgcagta tttcttggag cgtgatttgg ttcatgtgat tgcaagtgat
     3481 atgcacaatc tagacggtag acctcctcat atggcagaag catatgacct tgttacccaa
     3541 aaatacggag aagcgaaggc tcaggaactt tttatagaca atcctcgaaa aattgtaatg
     3601 gatcaactaa tttaggagaa atgatgaaag aacaaaacac gatagaaatc gatgtatttc
     3661 aattatttaa aaccttgtgg aaacgcaagc taatgatttt aatagtggca cttgtgacag
     3721 gtgcgggggc ttttgcatat agcactttta ttgttaagcc agaatatacg agtaccacgc
     3781 gaatttacgt agtgaatcgc aatcaaggag acaagccggg gctgacaaat caggatttgc
     3841 aggcaggatc ttatctggta aaagactacc gtgagattat cctttcgcag gatgcattgg
     3901 aaaaagtagc gacaaatttg aagttggata tgccagcaaa aacgttagcc agcaaagttc
     3961 aagtgactgt accagctgac actcgtatcg tctcaatctc tgtcaaggat aaacagccag
     4021 aggaagccag tcgtatcgct aattctctac gagaagttgc tgcagaaaag atcgtcgctg
     4081 taacgcgagt atctgatgta acgacacttg aagaagcgcg accagctacg actccctctt
     4141 ctccaaatgt tcgacgcaat tccttgtttg gttttcttgg aggagcagtc gtaacagtaa
     4201 ttgctgttct tttgattgag ttgctggaca cccgtgtgaa acgtcctgaa gatgttgaag
     4261 atgtactgaa aattccactt ttagggctcg ttccagattt tgacaaaata aaataggagg
     4321 aagttatgcc aacattagaa atctcacagg caaaattgga ttctgtaaaa aaggcagagg
     4381 aatattataa cgctttgtgc acgaacctac agttaagtgg agatggtttg aaagtatttt
     4441 ctatcacttc tgtgaaaata ggagaaggaa aatcaacgac ttccgccaat atcgcttggg
     4501 cttttgcgcg tgcaggttac aaaacgctgc tgattgatgg agatattcgc aattctgtta
     4561 tgttaggtgt ctttaaagca aggaataaga ttacaggcct gacagaattt ttatcaggaa
     4621 ctacagactt atcacaaggg ctttgtgata ccaatatcga aaatctcttt gtaattcagg
     4681 ctggctctgt gtcaccgaat ccgacagctc ttcttcaaag taagaatttc actacaatgc
     4741 ttgaaacctt gcgtaaatat tttgactaca tcattgtaga tactgctcct gttggtgtcg
     4801 tgattgatgc ggctattatt acgcgaaact gcgatgcttc tattttagtg acggaggcag
     4861 gtgaaataaa tcgtcgggat attcaaaaag caaaagaaca gttggaacac acaggaaagc
     4921 cgtttttggg aattgtgttg aataaattcg atacttcagt agacaaatac ggttcttatg
     4981 gaaattatgg agattacggg aaaaataaaa aataggtcgg gggatagaga tgaatggaaa
     5041 aatattaagg tcttcattgg ccataatcca gagttttctt gttattttat tgacttatct
     5101 acttagtgct gtgagagaaa cggagattgt ttcaacaaca gctattgcac tttatatcct
     5161 ccattatttt gtcttttata tcagtgatta tggacaggat ttctttaaaa ggagatattt
     5221 gattgaactt gtccagacat tgaaatatat cctattcttt gcactagcga ttagtatttc
     5281 taattttttc ttagaggatc gatttagtat ttccagacga ggcatgattt acttcctcac
     5341 attacatgct ctcttagtct atgtgctaaa cctatttatc aagtggtatt ggaagcgggc
     5401 ttatctcaac tttaaaggaa gtaagaagat tctcctactt acagcaactt ctcgtgtcga
     5461 aaaggtactg gatagattaa tagaatcaaa tgaggttgtt gggaagttgg tagccgtcag
     5521 tgtcttagat aaaccagatt ttcagcatga ttgtttaaag gtagtagcag agggggagat
     5581 agtaaacttt gcgactcatg aggtggtcga tgaagtcttt atcaatcttc caagtgaaaa
     5641 atacaatatt ggagagcttg tttctcagtt tgaaacgatg ggaattgatg taacagttaa
     5701 tctaaatgct tttgatcgta gtttggcacg taacaagcaa attcgtgaga tggcaggatt
     5761 aaacgttgtg actttttcta caacatttta taagactagt catataatgg ctaagcggat
     5821 tattgatatc atgggtgcat tggtagggct gatactatgt ggtttagtca gtattgtact
     5881 ggttcctttg attcgaaagg atgggggttc tgctattttt gctcagacgc gtataggaaa
     5941 aaatggtcgt cagttcactt tttataagtt tcgctctatg tgtgtagatg ccgaggcgaa
     6001 aaaaagagaa ctcatggaac aaaataccat gcagggtgga atgtttaagg tggacgatga
     6061 tcctcgtatc acgaaaattg gtcgttttat acggaagact agcttggacg agctaccaca
     6121 gttttataat gttctaaagg gagatatgag tttggttggc acacggccac caacagtgga
     6181 cgagtatgaa cactataccc cagaacaaaa acgtcggcta agttttaaac ctggtataac
     6241 aggcttatgg caggtcagtg gacgaagtga gattaagaat tttgatgaag ttgtcaaatt
     6301 agatgtagcc tatatagacg attggacaat ttggaaagat attgagattt tattgaagac
     6361 agttaaagtt gtattgatga aggatggagc gaagtagatt gatagatgta aaaatcattg
     6421 tggcaacaca taaagaggtt aaaatgcctc aagacaatag tctttacctt ccaatacatg
     6481 ttggaagaga cggtaaatca gatattggtt ttatcggtga taatactggc gataatatat
     6541 cctctctaaa tccatattat tgtgagttga cgggacttta ttgggcatgg aagaatcttg
     6601 attataatta cttaggtcta gttcattacc gtcgttattt tacaaataaa tctcaagggt
     6661 ataatgaaaa tgtcaatatg gatgacgtca ttttgtctcg atctaatgtt gaaatattat
     6721 tagagaaatc tgacgtaata gttccaaaga agcgaaagta ttatattgaa actctttatt
     6781 cacattatgc ccataccctt aacggagaac atctggatct tgctaggaaa attattgagc
     6841 aaaatagttc agagtatctt tcatcctttg ataaagtgat gaaacaaaga agcggttata
     6901 tgttcaatat gtttatcatg aaaaaaggac tattagatga ttatttaccg tggctttttt
     6961 ctattctgga tactatgtac gaacagatgg acttgaccga ctatacttca tttgagtcac
     7021 gtttattcgg gcgagttagt gagttgttgt ttaatgtttg gttatgtaaa aaaggaataa
     7081 cgcctaaaga ggtaccattt atgtacatgg agagagtgga tttgtttgaa aaaggaaaat
     7141 cttttttaat ggctaaattt tttggaaaga agtatggaca gagtttctag gagggaatat
     7201 gaaaatcact atcaaaaggt attcactgcc agaaatttta ggattagcag cattagctat
     7261 attcctacta ttttcgttat taagtataac tctttatgcc caatatatat ctattaaagt
     7321 atattttatt gcactttttg gcattatttt attaatattt ctgaaggaac ttatatctga
     7381 gagttataat cttaaatctg tgattggatt attcgtgatt tttactctct gcttcatcat
     7441 aggtaccgtc acgaattacg catacttttt tattttaggt ctgtttttga tttatagtct
     7501 tagaaatctc cctttttcag acgtagccaa agtctccttt atcattagta ttagtgtatt
     7561 gctcctagta gtattgagta gtaagcttgg tattattcct gattatattg agatttcgcc
     7621 taccagagtt agacactatc ttggtttccg atattcatta cttccatcaa cgcttatgat
     7681 gaatatcata gctatatcat tttttttaaa gcaagaaaac gcttcatatc cgcgtcttct
     7741 tgtattgttt ttactttcag gatggttata cgtagaaaca gattcacgtt tgacttttat
     7801 taattcgtgt ttgtttctac tggttaattt aataatgaaa ttgtcacctt ccatcattga
     7861 aaaggtaggg agactgttaa aacttttttc gttcacctac tttattaatg cctgtttgag
     7921 ttactggatt gcgaagactt acttaaacac ctcaaatgtt gttttgaatc aattctttta
     7981 ccaagcggat caatttcttg gaggacgtat ttattattct aatcgttcgt tatctttata
     8041 tggatataag ttgttaggtc aaaagattga ttggattgga aatggcttga gcatacaagg
     8101 ggagcgtagc acagaaacat atttgtatgt ggataattta tatatccaga ttcttcaaca
     8161 ttttggtttg atagtttcgg taattatttt aagtctatta actataactt tagtaaagct
     8221 tttgaaaaag gggcagatgg tattaggaat tattttagtt attttgagtt ttcatgcttt
     8281 aattgatgat ttgatactaa atctatatta taatatcttt tgggttttga taggaatgtt
     8341 gatatataaa aagtatcaat tttatgataa aaagcagttg acaatagaat aagaagcaag
     8401 cattggaaat agacattcag atatgtacaa gaaaactcga tttaagtttt ttggtaaaat
     8461 ttttaaaatt aagttgtaaa atggatatca aaatctcacc ttttttgtag gtgtgattaa
     8521 acagagggat attagatagg aaaataatga ataagattaa tttaactgat aatttaccgt
     8581 taatttcagt tgttttacca gtatacaacg tagagaatta tttagaaaag tgtttgaatt
     8641 ctgttgtgag acagacgtat aaaaacatag aaattataat agtaaatgat ggcagcttag
     8701 attcttcaat agatatttgt aataagtatg caaataaaga tagtcgaatt aaagtattta
     8761 caaaacctaa tggaggtttg tctgatgcta gaaatttcgg tgtcaaaaaa tctatgggtg
     8821 agtttataac attcgttgat tcagatgact atgttacaga tgattatgta gaatatttgt
     8881 atagcttagt caaaaaatat aattgtaaaa tgtcaatgtg ttcaatattt gtccattata
     8941 tttctaatga taaaatgatc aataatggga caggaagaga attgatgatg acagcagagc
     9001 ggtgtattga aaaaatgtgc tatcatgatg aggtggatac atgtgcttat gcaaaattat
     9061 atcatagaag tctatttagt gaaatatgct tccctaaagg aaggatattc gaagatattg
     9121 gaacaattta tcgctttttt ggtactgctg ggcagattgc ctgtggtttt aacgcaaaat
     9181 attattatga gattcgggaa aattcgattg ttacatcatc atttagtgaa aaaaaatttg
     9241 atttgttatt tatgacagat caaatgcgaa attttgttga tcaacgttat ccatctttga
     9301 aagctgcaac aaaacgtcga gctgtctatg caagatttag tacccttaac caattattag
     9361 atgtacaagg atataatgaa gaaaaaaaag aaataattcg ttttatccaa gacaacaagg
     9421 aagcgttact tgaaaatcct aagactccta agcgggatag attagctgtt agagctctct
     9481 cccttggatt ttgcatttat aaattgttat ggaagcaata tctaaaaatt caaagaggtt
     9541 agtatgaata aagaattttt gaagtatatt tatattcgat tattaagaaa tttaaggaga
     9601 attttcttta ttatcccgat aataaggaat agagttgttt ttgaatcttt ctcaggagat
     9661 gcttatagtt gcaatcctaa atatatttct gaagaattaa gaaaacagta tggtgattct
     9721 gttgaaatta tctgggcttt taatgatcca aacaaattca aaaaagaatt accaaaggag
     9781 attgtgactt gtcgttaccg tagtttcaat catctgatct atagaatcac ttcaaaagtt
     9841 tatgtttgta atttcctgca agcaattgaa attccaaagc gtaaaggaca actagagatt
     9901 caaacttggc atggaggagg ttgctataaa aaagttgggg tggctgaaaa aggacgccag
     9961 gctgcttatg ttaaacgaca acggatgcac gttgaagaaa cagatctctt tattacaagt
    10021 agtaaatatt ttgaaaatga ggtagtaaaa aaacaatttg ggtataaggg agaaatttta
    10081 tctattggta tgcctcgaaa tgatatttta ataaatttac caatttcaag tcaagttgag
    10141 aaattaaagg agaaattggg attaccaaac aataaattga tagcacttta tgctccgacc
    10201 tggagatcag gtactaaaca gtatgaaaca cttgatataa aaaaacttac tcaagccgtt
    10261 gataaaaaat ttggtaaaaa atgtatcgtt cttttcagat cgcatctata tggaaatcaa
    10321 tcttatgatg atgttgtgga tgtctctcag tatagtgata tgcaagaatt attgttgctt
    10381 tcagatatac tgattactga ctattcttcg tctatgtggg atttctctct ctcttttaaa
    10441 ccgtgttttt tatatacccc cgatttgaag gattatctag atgaaagagg ttttgatgaa
    10501 gatatacatt catggggatt ttcagtttct gaatcaaata aggaactagt tgaaaatatt
    10561 ttacagtttg ataatgaaga atatagacaa aaaatgaaga atcatcatca gtttttagaa
    10621 tcttatgaac aaggagatgc agcgaaaaga gtcgtggcga agattgctga atattgtaat
    10681 ttatatagag gatagataat gaaaaaaatt gcttatttga tcaaaagata tggtgtgaaa
    10741 aatgtggttt tacgtgctat taatgatgtt ctaccagtca atctcatctt tcccagtcaa
    10801 caactcagac gtttgaattg gcaagaaaaa gtcaaaaaga agttaaaaaa atatgtagtt
    10861 atttcggatt caatcaagag tgaggaggaa tgcgatatta tctggtggct atggtttcaa
    10921 ggacttgata atgcaccagc tattgtgaaa aaatgtagag agtcggtaga taaatatgct
    10981 aaacgcagtg gcaaaagggt tattgagtta acatctcaaa atttatttga atatattgag
    11041 gtacctaacg aactctatgt gaaatataag tcaggtagtt tgccactagc tttattttca
    11101 gatttttgtc gaattagcct tctttctaac tatggaggat tatggattga ttcaactgtt
    11161 ctaattacgg gggaaattga agatgagata ttgaaccaag atatttttat gtttcaagct
    11221 tctcctttag actattcagt tactaaaatc agtaattgga tgttatattc aaaatatcca
    11281 ggacacccgt tcatatcatc gatacgtgat actttgattt cattttataa taagaataat
    11341 acgatcccag attatttttt atttcattta cttgtttcct gtttaataga tgataatagg
    11401 ataaatcaaa gtttttatga tatggattat tataccaata cctatcctca cttattaggg
    11461 agagttttga gcgaaccata tgatactttg aaatttgaaa atattttaag gaaaacgtct
    11521 attcataaat tatcatataa aaatttagat aatgttgctg aagatagctt ttataatgct
    11581 attttaggtt tagattttag ttagtaataa agaggagaga aatgaattta gcagttattt
    11641 ttgctggagg ctccggtacg cgaatgaatg caaaggatag acctaagcag tttcttttgg
    11701 tacatggtaa gccaattatt gttcacacta ttgagctatt tgagaaccat ccagagattg
    11761 atggaattat cgttgtttgt attgaagatt ggattccgta tatggaggag atgaaatatt
    11821 gctatagatt agataagatt gctaagattg ttccaggggg ggcaactggt caattatcta
    11881 tttataatgg tttagtcgcg gctgaacaac tttatggaat agaggataat gttgtgttaa
    11941 tccatgatgg agtccgtcct ttaattacag cagacactat ttcagataac atccaatccg
    12001 taaaagaaaa gggaaatgct attacttgta cagtggccaa agaaacagtt atcttagtag
    12061 atgatgaaaa taaggtagac gaagtgccta gtcgtgaaca ttcgcgattt gccaaggctc
    12121 ctcagagttt ttggctaaaa gatattctag gtgcacatcg agcctctgta gataatggta
    12181 gaaataattt tattgattca tgcaccatga tgagatatta tggtcatgat ttacatgttg
    12241 ttgttggtcc gtatgagaat attaagatta caacgcctga tgatttttat acatttaggg
    12301 ctttgtacga tcttcgtgag aataagcaac taaaataatg aggaaaagat gaagtatttt
    12361 gttgaagaaa cgttacttga tgaacaggat aaaaaaaatg cgggtggaaa ggctagacaa
    12421 gacgtcactg atattttaga gtccataggt tatcagaagt taatagctga gtccgaaatg
    12481 aatgaacgtc aggaattaaa tgctgttcaa agattggttc atcattataa agttaagaaa
    12541 atgtggaaga aaactctttc agttgttggt aagggtgatg aagttattat tcaatttcct
    12601 ttactaaatc atagtttatt ctttaatcag gttattaagc aacttagtaa gaatggagtt
    12661 aaagtttatt ttttgattca tgatttagaa tcgttgcgat ggtcgcagtc aaaatcgata
    12721 tcattaaaaa gtaggattcg attaaacatt gaagaacata gtgttttaag gttatcagaa
    12781 ggcattattg ctcataataa aaaaatgaaa tcttatatta agacctactc tgttgaaagt
    12841 tctaaaatta ttcctcttga aacttttgat tatattattc catcttatca tgaaagaaaa
    12901 aatctggata actttcagtt aaatgctcca attgttattg ctggaaattt aaagcaacat
    12961 aaagctggat atgtctatca tttaccaagc aatgtggagt ttaatcttta tggaattgga
    13021 tatgaacaga cagatgacaa aagtgtgcac tactgtggtt cttttatgcc agaagaatta
    13081 ccattcgttt taaaaggaag ttttggattg gtatgggatg gtccgtcatc agagtcttgt
    13141 atagaaactt atggagagta tcttcgtgta aacaaccctc acaagacttc actatattta
    13201 gcttcaggca taccagtagt tgtatggtca gaggcagcaa tagctagttt cattaaggag
    13261 aataattgtg gtattcttgt atccaatctg agtgaactac ctgagttact ttctatgatt
    13321 accgttgatg aatatgaatt gatgaaaaag aatactgaga ttattggaga aaggcttcga
    13381 caaggttttt atactaaaca agcagttaaa ggtttctaga ctggaggaag tgtaatgatt
    13441 gaaagtttta atgataaagt gttgcaggaa gatttagaga taattgcaaa agaagagctc
    13501 ccatttcgaa aatttagaaa ttcaactgtt tttatcacgg gagtaacagg tttagtaggc
    13561 cttcaattat ttaaggcttt ggcttgtatc aatagagtcc atcagttgaa tatgaaaatt
    13621 attggtctag tcagaaattt ggataaagca gaaaaaattt ttggagattt attgaaacgg
    13681 aaggatatac aaatagtttt aggagatgtt tcggaagatt tccactcgta tatccctgat
    13741 ggtttagtta ttgactatat cattcacgga gcaagcgtga ctacctctaa actcatgatt
    13801 gaatttccag tagatacaat tcgagtagct tttaatggaa cgtatcaaat gttagaattg
    13861 gcaaaagaaa aaaaagtgaa aagttttgta tatctttctt caatggaggt atatggtagc
    13921 tttcagtcag atagaacaac tgttgtaaac gagaatatgt tagggtatct tgatttgaca
    13981 tctgttcgaa caaattaccc agaatgcaaa agaatttgtg aaaatatgtg cattgcattt
    14041 ctaagtcagt atcaagtccc ggctaagatt gctcgtctat cccagacctt tggtgcaggc
    14101 actctaccgg gtgaaaatag agtatttgct caatttgctc gtagtgttat gcaagggaaa
    14161 gatattgttt tacatacgtt agggcaatca gaaggaaatt actgctacac agctgatact
    14221 gttgttgcat tattaacaat tctattgaga ggagaaaatg gggaggctta taatattgct
    14281 aatgaagaga gtcatacaac aatagcagat atggcaaaaa tggtaacttc gcaattctct
    14341 caaacgagtc aagtggtttt tgatattccg aagaaaaata tatttggtta tgctgtagat
    14401 actaaaatga agttatcaac acacaaaatt caacaattgg gttggaagcc gagggtctct
    14461 cttgtagatg cttatgatcg aatgatgaga agtatgaatg aaactggggt atagataact
    14521 atatgaaggt attaaaaaac tacttatata atctctctta tcaactatta gttattattc
    14581 ttcctatcat tacgactcct tatgtgacgc gcatattttc ttcagatgat ttagggacat
    14641 acggttactt caattccatt gttacctact tcattttact tgctactctg ggtattgcta
    14701 actatggaac gaaggagata tctgggaata ggaagagtat tcagaaaaat ttctggggaa
    14761 tatatacttt acagtttgga gcgactactt tttccatttt tctctatata ctagcctgtc
    14821 ttttcatccc agggatgaaa aacctagttg catatatctt gggattgggt ttagtctcta
    14881 aaggactaga tatttcatgg ttgtttcaag ggttagaaga ttttcgtaaa attacggtca
    14941 gaaatatcac agtgaagctt gttggtgtaa gtgccatttt cttgtttgta aaatcagcga
    15001 gtgatctata cttgtatgtt tttcttctaa cagcatttga attgttgggt cagttaagta
    15061 tgtggtttcc agcccgtgaa tatattggaa aaccacattt tgatatagaa tatgctaggc
    15121 atcatctgaa gccagttatc ttgctattct taccacaaat tgctatctcg ctttatgtga
    15181 ctttagatcg tacaatgtta ggggcgctag cttctacaaa agatgtcggc atttatgatc
    15241 aggctttgaa gctggttaat attttactga ccttggtaac ttccttggga agtgttatgc
    15301 tgccacgcgt tgcgcatttg ttagcgacag gtgatcataa ggtagtcaat aagatgcatg
    15361 aggtatcctt cttaatttat aatttggtta tttttccgat tatggcaggg atgttgattg
    15421 tgaatgatga ttttgttcaa tttttccttg ggcaagactt tcaagatgca cgctatgcaa
    15481 tttccattat gatcttccgt atgttcttta tcggttggac taatataatg ggaattcaga
    15541 tactgatacc tcataatcaa aataaagaat tcatgatttc aacaacaact cccgcaatta
    15601 tcagtgtagg tttgaactta ctattccttc ctaaactggg atatatcggg gcagccattg
    15661 tctctgtttt aacagaggca cttgtatggg caatccaatt attctatact cgcagatatt
    15721 taaaagaagt tcctataatc ggatcaatgt caaaaattat actagcatct gccattatgt
    15781 atggcctttt actaagttca aaaacagtta tacatttttc accgacctta aatgttctag
    15841 catttgtagc gcttggtgga atcatttatc tttttgcaat tctatctctg aaagtggtag
    15901 atgtgaaaga attaaaacaa attattagga aaaactagaa tgagaaaaaa tcgaaatatc
    15961 aacctagatt tactaaaagt gcttgcatgt gttggagttg ttttacttca tacaacaatg
    16021 ggcggattta aagagacagg ttcatggaat cttttggcat atttatatta tttaggtact
    16081 tactctattc ccttgttttt tatgatcaat ggttatttgt tgttaggcaa gagggagata
    16141 acttatcttt acatactcca gaaagtaaaa tggattttaa taacagtgtc atcatggtca
    16201 tttatcgtat ggctttttaa gcgtgatttt acaactaatc ctattaaaaa aattgtaggt
    16261 tctttgatac aaagaggtta tttctttcag ttttggtttt tcggtgcact catacttatc
    16321 tatttatgtt tgccaatttt gagacaattt ctaaattcaa aaagaagcta tttatacagt
    16381 ttatctttat tgatgactat tggtttgatt tttgagttat caaatatcct acttcaaatg
    16441 ccaatacaaa catatgtaat acaaactttt agattatgga cgtggttttt ttactatctt
    16501 ttaggtggtt atatagcgca attcactata gaagaaattg aatcaaggtt taagaattgg
    16561 atgaaaatag ttagcatact tttgttattg atttcaccaa taatattatt tttcatagcg
    16621 aagactatat accataatct atttgctgaa tacttttatg atactttatt tgtaaaagtc
    16681 agtactttag gaatttttct aactatcctc atgcttactt tgaatgaaaa ccgaagagaa
    16741 tcgattgttt ccctttctaa tcaaacaatg ggggttttca taatacatac ttatattatg
    16801 aaagtgtggg aaaaagtgct tggttttaat tttgtaggag catatttact ttttgctcta
    16861 tttactttaa gtgttagttt tattattgtt gggatgttaa tgaagattcc ttacttcaat
    16921 cgaatcgtca aattataaaa aggagaacaa gatgtacgat tatcttattg tcggtgctgg
    16981 tttgtcagga gcaatttttg cttatgaggc gaccaagcgt ggaaaaaaag taaaagtgat
    17041 tgataaacgt aaccacattg gtgggaatat ctactgtgag aatgtagaag gagttaatgt
    17101 tcataaatat ggtgcccata tctttcatac ttctaataag aaagtttggg attatgttaa
    17161 tcaatttgct gaatttaaca actacgtcaa ctcgcctgta gctaattaca agggtagcct
    17221 ctataatcta cctttcaata tgaatacctt ctatgctatg tgggggacaa aaactcctca
    17281 agaagtcaaa gataagatta ctgagcagac agctgatatg aaggatgttg agccgaaaaa
    17341 tctggaagaa caggctatca agttgattgg tccagatgtc tatgaaaagt taatcaaggg
    17401 ttatactgaa aagcagtggg gacgctcagc aacggaactt cctccattta tcattaaacg
    17461 tcttccagtt cgtttaacat ttgataataa ctattttaac gaccgttacc aaggaattcc
    17521 tattggtggt tacaatgtca tcatcgaaaa tatgcttaaa gacgttgaag ttgagcttgg
    17581 tgttgatttc tttgctcatc gtgaagagtt agaagcatca gctgaaaaag ttgtctttac
    17641 agggatgatc gaccagtatt ttgactacaa gcacggagag ttagaatacc gtagccttcg
    17701 ctttgatcat gaaattttgg acgaggaaaa ttatcaagga aatgctgtag tgaactatac
    17761 ggagcgtgag attccttata ctcgtattat cgaacacaag cattttgaat atggaacaca
    17821 ggcaaagaca gttatcacgc gtgaatatcc agctgactgg aagcgtgggg acgagcctta
    17881 ctatccgatc aacgatgaga aaaataatgc tatgtttgct aagtaccaag aggaagcttc
    17941 aaagaatgat aaggttattt tctgtggacg tttagcagat tataaatatt acgatatgca
    18001 tgtggtgatt gaacgggcgc ttgaggttgt ggagaaagag tttggatatg acaaaaagta
    18061 gaatcaattg gatagatttt ggaaaaggct tttccatatt tttagtctta gcaggacatg
    18121 tgttgcttgg actgtatcaa tcggaaaaat ttcccacagc aaataacata ctatcgttgt
    18181 tgatagcaca agtctacata tttcatatac cagtattttt tgccttatca ggatactttt
    18241 tcaaacctgt gtcggatttg aaggagttct ggcaatatgc taaaaagaag acaattgttt
    18301 ttggtctgcc atatattttc tattcgatca ttcactttgg tcttcaaaaa gttgcagggg
    18361 catctgttcg tgttcctaca accatatctg atttgctaaa tatctataaa catcctcttg
    18421 gagtttcatg gtatttatat atactctggt cgattttgat aatctatgga ttattgtcta
    18481 ttttagtcaa aaatcgtaga atgttatttt tgataagtgt tttcgcttat tgtttaaccc
    18541 tatttgttca aacagatatt tatattattc aaagaacgct agtttggggg atttgtttct
    18601 ttcttggcag tgtattgagt gaaattcact ttgataaaat taatttgaaa aaatttcttt
    18661 ttttctttgt gttatttgat tttatttata tgttcgcttg gttcttgttt tatgaagtag
    18721 ggtctaagaa ggattatgta agctatatta acccaggttt gtgggggatt gcttttattg
    18781 tctgtgtatt agttgctttt gcgatttttc ctaaaatgga gaaaaatttt cctaaaactt
    18841 tcctatattt cactaaatac gggaaagata gtttagggat ctatattctt catgcaccaa
    18901 tttgtagcat gattcggatt ctaatgttga aagtgggaat aaactcagtt tttcttcacg
    18961 ttgttgttgg gattgtgcta ggctggtatt tatccatact agcaacttat atattgaaaa
    19021 aaattccatt tttgaatatt gttttattac cacaaaagta tattaaatta aaataaatta
    19081 ttttagattt ataatgtggc tctttgtcaa ctaacatctg gagaggacaa tcactgtctt
    19141 ctcttttttt gtcttttcag aatataccaa attaacacaa aaattctgaa aattctgttg
    19201 acatctttct gaaaagagtt tataatggag agaaagtttt aaaggagaaa atgatgaaaa
    19261 gttcaaaact atttgccctt gcgggcgtga cattattggc ggcgactact ttagctgcat
    19321 gctctggatc aggttcaagc actaaaggtg agaagacatt ctcatacatt tatgagacag
    19381 accctgataa cctcaactat ttg
//
