LOCUS       CR931718               27591 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain Eddy nr. 72 (serotype 45).
ACCESSION   CR931718
VERSION     CR931718.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 27591)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 27591)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..27591
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Eddy nr. 72"
                     /db_xref="taxon:1313"
     gene            <1..163
                     /gene="dexB"
                     /locus_tag="SPC45_0001"
     CDS             <1..163
                     /gene="dexB"
                     /locus_tag="SPC45_0001"
                     /codon_start=2
                     /transl_table=11
                     /protein_id="CAI34573.1"
                     /db_xref="GOA:Q4K2R1"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="UniProtKB/TrEMBL:Q4K2R1"
                     /translation="DRRFLVVANLSNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVP
                     WDAFCVELL"
     gene            322..490
                     /gene="aliB"
                     /locus_tag="SPC45_0002"
                     /pseudo
     CDS             322..490
                     /gene="aliB"
                     /locus_tag="SPC45_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(488..808,810..1355))
                     /gene="tnp"
                     /locus_tag="SPC45_0003"
                     /pseudo
     CDS             complement(join(488..808,810..1355))
                     /gene="tnp"
                     /locus_tag="SPC45_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase"
     misc_feature    complement(966..1337)
                     /gene="tnp"
                     /locus_tag="SPC45_0003"
                     /note="HMMPfam hit to PF01710, Transposase, score 7.2e-22"
                     /pseudo
     gene            1581..3035
                     /gene="wzg"
                     /locus_tag="SPC45_0004"
     CDS             1581..3035
                     /gene="wzg"
                     /locus_tag="SPC45_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI34576.1"
                     /db_xref="GOA:Q4JYP2"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP2"
                     /translation="MLIMSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNI
                     LAFRYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGL
                     TNRLNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNT
                     DLTVNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKV
                     GAPKTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPI
                     ADGGNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGVDVH
                     NDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKL
                     TSTEALKNYSTIINSLQDSIQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDL
                     PSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1581..1706
                     /gene="wzg"
                     /locus_tag="SPC45_0004"
                     /note="Signal peptide predicted for SPC1965 by SignalP 2.0
                     HMM (Signal peptide probability 0.999) with cleavage site
                     probability 0.540 between residues 42 and 43"
     misc_feature    1794..2141
                     /gene="wzg"
                     /locus_tag="SPC45_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 2.3e-64"
     misc_feature    2319..2762
                     /gene="wzg"
                     /locus_tag="SPC45_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 8.4e-70"
     gene            3037..3768
                     /gene="wzh"
                     /locus_tag="SPC45_0005"
     CDS             3037..3768
                     /gene="wzh"
                     /locus_tag="SPC45_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI34577.1"
                     /db_xref="GOA:Q4JYP1"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLVESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHNALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKSKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    3040..3648
                     /gene="wzh"
                     /locus_tag="SPC45_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 8.2e-36"
     gene            3774..4469
                     /gene="wzd"
                     /locus_tag="SPC45_0006"
     CDS             3774..4469
                     /gene="wzd"
                     /locus_tag="SPC45_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI34578.1"
                     /db_xref="GOA:Q4JYP0"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP0"
                     /translation="MMKEQNTIEIDVFQLVKSLWKRKLMILIVALVTGAGAFAYSTFI
                     VKPKYTSTTRIYVVNRNQGDKSGLTNQDLQAGSYLVKDYREIILSQDVLEEVVSDLKL
                     DLTPKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDV
                     TTLEEARPAISPSSPDIKRNTLIGFLAGVIGTSVIVLLLELLDTRVKRPEDIEDTLQM
                     TLLGVVPNLDKLK"
     misc_feature    3795..4211
                     /gene="wzd"
                     /locus_tag="SPC45_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.5e-56"
     misc_feature    4317..4394
                     /gene="wzd"
                     /locus_tag="SPC45_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4479..5162
                     /gene="wze"
                     /locus_tag="SPC45_0007"
     CDS             4479..5162
                     /gene="wze"
                     /locus_tag="SPC45_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI34579.1"
                     /db_xref="GOA:Q4JYN9"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN9"
                     /translation="MPTLEIAQKKLEFVKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIAISFACAGYKTLLIDGDTRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGTVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDIQKAKQQLKQTKKLFLGVVLNKLDISVDKYGIY
                     GSYGNYGKR"
     gene            5485..6138
                     /gene="wciI"
                     /locus_tag="SPC45_0008"
     CDS             5485..6138
                     /gene="wciI"
                     /locus_tag="SPC45_0008"
                     /note="member of homology group 29"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34580.1"
                     /db_xref="GOA:Q4JYN8"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN8"
                     /translation="MSNGNRMKNGNRIYSWRLFMYSIIKRLGDILLSLIGIIILCPVF
                     MIIAIAIKLDSEGPVIFKQKRFGIHKEYFYILKFRSMKIDAPKNVAPRNLYNPEQWIT
                     KVGAFLRKTSLDELPQLFNILVGNMSIVGPRPAGINELDLIAERDKYGANDILPGLTG
                     WAQINGRDTLSVEMKTELDGYYVKHLSLIMDIRCIVKTIPYVLKRKGIVEGSGKKES"
     misc_feature    5485..5634
                     /gene="wciI"
                     /locus_tag="SPC45_0008"
                     /note="Signal peptide predicted for SPC1969 by SignalP 2.0
                     HMM (Signal peptide probability 0.907) with cleavage site
                     probability 0.634 between residues 50 and 51"
     misc_feature    5557..6111
                     /gene="wciI"
                     /locus_tag="SPC45_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 4.3e-37"
     gene            6147..7373
                     /gene="wciJ"
                     /locus_tag="SPC45_0009"
     CDS             6147..7373
                     /gene="wciJ"
                     /locus_tag="SPC45_0009"
                     /note="member of homology group 35"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34581.1"
                     /db_xref="GOA:Q4JYN7"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN7"
                     /translation="MKILFVCQHYKPEPFRLSDICEDLVRKGHEVSVLAGIPNYPEGK
                     IYADYRHNKKRREIIEGVTIYRSYTIPRKKSVVFRLLNYFSFAISSTLGVLLGRYKTK
                     DGSNFDCVFVNQLSPVMMAWAGMAYKKKYKKPMFLYCMDVWPDSLTVGGVKQDGLIFK
                     LFKFISKKVYRASDYIFVTSPSFKNYFVKQFDISEQKITYLPQYAEDLFIPDESIVNK
                     ESVDLTFAGNIGKAQNLETILKAASLIEKNTNLPKKIHFHFVGDGTELLSMKALAHEL
                     ELKNISFYGRRSLEEMPSFYKKSDAMLVSLIGDSIVSRTIPGKVQSYMAAGKPIIGAI
                     SGDAKIIVEEANCGYVSPERDVKQLAKNICKFSMLSIKRQRELGKKARCYYENHFSKE
                     QFMTQLEKYLREEFSS"
     misc_feature    6765..7298
                     /gene="wciJ"
                     /locus_tag="SPC45_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 2.1e-12"
     gene            7370..8539
                     /gene="wcxB"
                     /locus_tag="SPC45_0010"
     CDS             7370..8539
                     /gene="wcxB"
                     /locus_tag="SPC45_0010"
                     /note="member of homology group 55"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34582.1"
                     /db_xref="GOA:Q4JYQ4"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4JYQ4"
                     /translation="MKILMINTVCGIRSTGRICTDIATALTKKGHEVKIAYGREYVPT
                     QYRNYAVKIGSRVDVNRHVLQARIFDNAGFVGRAATRKFITWVKEYDPDIIHLHNLHG
                     YYIHVGELFSYLKTCGKKILWTLHDCWAFTGHGAYFDTLECEKIGQCHHSSQKNDYPK
                     SLIDFSSRNFKRKKNLFTGVPNLTLITPSEWLANLVRNSFLKEYPVTVIHNGIDTTIF
                     KPRVLEAKKLRKKFRLEGKQVLLGVASIWDQRKGLDDLLELSVQLKSYQQLVLIGLSK
                     EQLNKLPKEIIGLTTTDSVEELSAWYTLADVFINPTTQDNYPTTNLEAIACGTPVVTY
                     PTGGSIESTYMYGIVCSDRTVVSILESLKEVSQCKRSPNFNLSKEYFVENILNLY"
     misc_feature    8042..8533
                     /gene="wcxB"
                     /locus_tag="SPC45_0010"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 1.3e-10"
     gene            8511..9650
                     /gene="wciL"
                     /locus_tag="SPC45_0011"
     CDS             8511..9650
                     /gene="wciL"
                     /locus_tag="SPC45_0011"
                     /note="member of homology group 30"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34583.1"
                     /db_xref="GOA:Q4JYQ3"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4JYQ3"
                     /translation="MWKIYSIYTSGTGVDMIKILYVNGGTMDRGGVSTFMMNVYEKMH
                     SEKIQIDFLVHTLSEGVRDEDILNLGGKIFRVPARGKNPLKNYRQIKQIMLNGNYDVV
                     HAHADAGNRTILSIAKECDIPIRISHCHNTNYTNKSLLKKFLNEQFKKQIPRYATHLW
                     ACSEKAGEWLYGNHSFEVIPNAIDVQKFIYSPQLSKDLRKELNLENKFVIGHVGRFDY
                     QKNHDFLLKVFTEFINEREDAHLVLIGKGELEEVIKKQANHLGILDKISFLGESSNVN
                     ELINVFDVGVFPSLFEGFSIAMVEMQVNGLPLVVSDNVPSEINLTDNIRFLSLDETVK
                     YWCKTILETKGRDTGAVDKIIAKGYNLSDMVHKLTKTYERIVDKS"
     misc_feature    9093..9593
                     /gene="wciL"
                     /locus_tag="SPC45_0011"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 6.2e-25"
     gene            9647..10756
                     /gene="wcyQ"
                     /locus_tag="SPC45_0012"
     CDS             9647..10756
                     /gene="wcyQ"
                     /locus_tag="SPC45_0012"
                     /note="member of homology group 202"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34584.1"
                     /db_xref="GOA:Q4JYQ2"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4JYQ2"
                     /translation="MKKVLFVTNIPSPYRVDFYNQLGKFVDLTVVFEATGAQDIRFDY
                     REIFKNFTAIFLSEGNIDEKKLNSAIFQYLIPKKYDYIFLTNYSYRTELFGYLKCVFS
                     KIPFVLEIDGGKIPESENFLKYQFKKFILTKPYYYFSPSQSSDDFLAHYHVNKENIYR
                     YSFTSLSEKDIRYQIVDEKEKQFLRKKLGFSPTKKTILFVGRIIPGKGVDVLIKAVQN
                     LSDDVQCLIVGPSPDSEYKQYLLDLIGQDSRFHFIDFLQTSELKQYYKLSDIFVLPTK
                     SDVWGLVVNEAMSQGLPVISTSACVAAIELVSNGNNGYIIDRVDDWKAIFQKLSKVLQ
                     DDSLRVQLSQNALSTIKHYTIETMVKEHLKFMEEK"
     misc_feature    10187..10693
                     /gene="wcyQ"
                     /locus_tag="SPC45_0012"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 3.2e-35"
     gene            10753..11673
                     /gene="wcxS"
                     /locus_tag="SPC45_0013"
     CDS             10753..11673
                     /gene="wcxS"
                     /locus_tag="SPC45_0013"
                     /note="member of homology group 104"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI34585.1"
                     /db_xref="GOA:Q4JYQ1"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4JYQ1"
                     /translation="MRISVAMTTYNGADYLLEQLESLRTQSLMADEVIIVDDCSTDNT
                     VELLDMYIQKYHLDNWVLIRNSSNIGWRKNFRKALQETTGDIVFLCDQDDIWNKDKIS
                     LMVKEFHKSPSIELLASNYEILDFGRNDKIKIRDVELDNGAVVPFSLKNKSISVMRPG
                     CTFAVKRELIVLLEKYDIDRFGHDNILWNLAMIRGTLYLYLKRLIHFRRHETSASAPN
                     QSLNRDRRVVEVDTSHQITVFLLDAARREHLDIKIISQLENMEMVLERRRDILKYGTL
                     MQIVHFQLKYHTYYPTFRNLLSDILVFLKK"
     misc_feature    10762..11271
                     /gene="wcxS"
                     /locus_tag="SPC45_0013"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 9.4e-34"
     gene            11689..13128
                     /gene="wzx"
                     /locus_tag="SPC45_0014"
     CDS             11689..13128
                     /gene="wzx"
                     /locus_tag="SPC45_0014"
                     /note="member of homology group 7"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI34586.1"
                     /db_xref="GOA:Q4JYQ0"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4JYQ0"
                     /translation="MSKISKNYLYNLIYQVVVLILPLLITPYVARILGAHQLGIYDYV
                     NSIVTLIYTLGLLGIGHYGNRECAYTRDDKEELSETFWSILAIQIILGFFSLLFLYIF
                     SNINSNYQVYFQLFSIWLFGSILDCTWLYRGLEEMQYVVLKNIIAKLLFTIATFLFVK
                     SETDLTLYVLIYGLSVLVANLSTYSQLRMFISRPKININRFTEIILGSLKLFLPSIIT
                     QIMLSADKIVLGSLSSGISNVSYYSNAEKIIQIPLSLIVVLNSVMMPRIANEFRNRRL
                     ENMKKYLTTAAEFSLFLAVPLSIGLYAIADTFVPWFLGESFMPSMDALKWLAPIAVGN
                     ALLGVSGSQYFVAVNKTKVLFFSNTLAAILNILLDLLLAPMFGVVGVCLATIVSLTSS
                     VIVQYYIMSKDIPIIPILKSLFKYLIYSMIMGMIIIVSFRGYPANYRTTIKQIVLGIV
                     VYFGLNLLTRDVFVFQTLDFVKKGFKKSR"
     misc_feature    11698..12501
                     /gene="wzx"
                     /locus_tag="SPC45_0014"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 2.1e-49"
     gene            13125..14213
                     /gene="wzy"
                     /locus_tag="SPC45_0015"
     CDS             13125..14213
                     /gene="wzy"
                     /locus_tag="SPC45_0015"
                     /note="member of homology group 257"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI34587.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP9"
                     /translation="MISALFYISFLTNLLVVVNRMRINSLAFLSWLILFFIYAGNIRE
                     GFSDLIHYRARYAVGKSSLYFSDHAYNFFADWFSHHSISFQVFLACIFLFSSACFYFV
                     AKKLHCNYNLLILLLSLFYFFYTLEVLRFFLATSVALIAHYYLSQNHRFIFIGLMFIA
                     FLFHGSIIYFLPFIIFYRQKNTSKMLWALVFISMVLIVTNLLVGNNSSYLTKIFELLG
                     SEVTKSRVMYYTAKSTRLGFILYDSYYIFNLLISINLKKIAKTVSNAPQEVTNFINLV
                     YQHSFFSTIFLPLIMFSTAFTRYLIFTVVLNFIAIAALQPFMQQSFIKLKSGLYIIFG
                     VLGATCFWWYLRENVLYFYEALLPNLFN"
     gene            14321..15175
                     /gene="wcyR"
                     /locus_tag="SPC45_0016"
     CDS             14321..15175
                     /gene="wcyR"
                     /locus_tag="SPC45_0016"
                     /note="member of homology group 203"
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase"
                     /protein_id="CAI34588.1"
                     /db_xref="GOA:Q4JYP8"
                     /db_xref="InterPro:IPR007074"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP8"
                     /translation="MINYSADELDMIQKLELKILKEIIRICKKEKIEYFLIGGSALGA
                     IRHEGFIPWDDDIDVGMTRENYDNFLRVAEQYLGEEFYLQSPSSDRKSPYSYSKLMLK
                     ETLFLEYAQRNLKTQSGIYVDIFPFDEVPDNESENERQFKAVQFYKKLYVMRMLPTVS
                     KAPENLIQGLKAILRRCIHYSLRLIPKSLILKKIDQFSRLYNGTNQSALACLDFPVRN
                     VEYVLKTTLYPLIEHKFEEITILLPGDFHQYLTTHYGEYMKLPPLEERVGHRPYLIDL
                     GTYGKEEK"
     misc_feature    14399..15085
                     /gene="wcyR"
                     /locus_tag="SPC45_0016"
                     /note="HMMPfam hit to PF04991, LICD Protein Family, score
                     2.1e-48"
     gene            15172..15576
                     /gene="gct"
                     /locus_tag="SPC45_0017"
     CDS             15172..15576
                     /gene="gct"
                     /locus_tag="SPC45_0017"
                     /note="member of homology group 28"
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol-1-phosphate biosynthetic protein
                     Gct"
                     /protein_id="CAI34589.1"
                     /db_xref="GOA:Q4JYP7"
                     /db_xref="InterPro:IPR004820"
                     /db_xref="InterPro:IPR004821"
                     /db_xref="InterPro:IPR006409"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP7"
                     /translation="MKRVITYGTFDLLHYGHINLLKRAKDLGDYLIVALSTDEFNLQK
                     DKISYFNYQQRKILLESIRYVDLVIPEISWEQKREDVKKYYADIFVIGDDWEGKFDFL
                     KDEGVEVVYLPRTKEISTTQIKEDLNKTKGGK"
     misc_feature    15184..15549
                     /gene="gct"
                     /locus_tag="SPC45_0017"
                     /note="HMMPfam hit to PF01467, Cytidylyltransferase, score
                     1.4e-22"
     gene            15566..16633
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
     CDS             15566..16633
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="member of homology group 36"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlA"
                     /protein_id="CAI34590.1"
                     /db_xref="GOA:Q4JYP6"
                     /db_xref="InterPro:IPR003869"
                     /db_xref="InterPro:IPR013692"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP6"
                     /translation="MENNMSQFTGKTLLITGGTGSFGNAVLKRFLETDISEIRIFSRD
                     EKKQDDMRHEFQVKVPEVAGKIRFYLGDVRDLASVKNAMHGVDYVFHAAALKQVPSCE
                     FFPVEAVKTNILGTENVLAAAIEADVKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAK
                     SRAVNPEHTKICVTRYGNVLCSRGSVVPLWIEQIKQGNALTITEPSMTRFVMTLEEAV
                     DLVLFAFEEGKSGDILVQKAPACTIEVLAKAVSEIFASEQDIKIIGIRHGEKMYETLL
                     TNEECANAIDLGNFYRVPSDNRNLNYDKYFKDGSTNRNLLTEFNSNNTDLMDVEQVKR
                     KLLELDEIQTAIRDMVADEEM"
     misc_feature    15599..16453
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.0019"
     misc_feature    15602..16273
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 6.6e-09"
     misc_feature    15602..16450
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 4.2e-163"
     misc_feature    15605..16240
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 9.6e-09"
     misc_feature    16451..16594
                     /gene="fnlA"
                     /locus_tag="SPC45_0018"
                     /note="HMMPfam hit to PF08485, Polysaccharide biosynthesis
                     protein C, score 2e-23"
     gene            16733..17962
                     /gene="fnlB"
                     /locus_tag="SPC45_0019"
     CDS             16733..17962
                     /gene="fnlB"
                     /locus_tag="SPC45_0019"
                     /note="member of homology group 37"
                     /codon_start=1
                     /transl_table=11
                     /product="FnlB"
                     /protein_id="CAI34591.1"
                     /db_xref="GOA:Q4JYP5"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP5"
                     /translation="MIKNILITGAKGFVGKNLICTLEALKDGRDRTRPNLEIGEIFQY
                     DRDTDPILLDEYCKKADFVFHLAGVNRPQNPDEFMEGNYGFSSRLLEILEKYENTCPV
                     LLSSSTQASLEGRFSNSIYGQSKLAGEELFFEYGKKTGAPVLVYRFPNLYGKWCRPNY
                     NSAVATFCHNLAHDLPIQVNDPSVELELLYIDDLIQECLTALEGNPHRCNLDGLQILP
                     SPSGNYCYVPTTHRATLGEIVSLLETFKKQPDSLVMPEIPQGSFKKKLYSTYLSYLPV
                     DKFKFPLKMNIDERGSFTELLKTENTGQFSVNISKPGITKGQHWHHSKWEFFMVVSGR
                     ALIQERRIGLDKNGQEYPILNFEVSGDKIEAIHMIPGYAHNIINLSDTENLVTVMWAN
                     ESFDPRHPDTFFEQVEK"
     misc_feature    16745..17368
                     /gene="fnlB"
                     /locus_tag="SPC45_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 6.9e-09"
     gene            17963..19147
                     /gene="fnlC"
                     /locus_tag="SPC45_0020"
     CDS             17963..19147
                     /gene="fnlC"
                     /locus_tag="SPC45_0020"
                     /note="member of homology group 38"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-L-fucosamine FnlC"
                     /protein_id="CAI34592.1"
                     /db_xref="GOA:Q4JYP4"
                     /db_xref="InterPro:IPR003331"
                     /db_xref="UniProtKB/TrEMBL:Q4JYP4"
                     /translation="MKIKTNYSDIHFKDNGKLKLLIIVGTRPEIIRLSSVITKCRKYF
                     DVILAHTGQNYDYNLNGIFFDDLGLDTPDVYMDAVGDDLGATVGNIINTSYKLMNQIK
                     PDALLILGDTNSCLSAIAAKRLHIPIFHMEAGNRCKDECLPEETNRRIVDIISDVNLA
                     YSEHARKYLHECGLPKERTYVTGSPMAEVLHKNLSAIESSDIHERLGLKKGGYILLSA
                     HREENIDTDKNFISLFTAINQLAEKYNMPILYSCHPRSKKRLQESGFKLDKRVIQHEP
                     LGFHDYNCLQMNAFVVVSDSGTLPEESSFFTSQGYPFPTVCIRTSTERPESLDKAGFI
                     LAGIDENSLLQAVETAVSLAEDEDFGLPVPDYVEENVSTKVVKIIQSYTGIVDKIVWR
                     KS"
     misc_feature    18074..19102
                     /gene="fnlC"
                     /locus_tag="SPC45_0020"
                     /note="HMMPfam hit to PF02350, UDP-N-acetylglucosamine
                     2-epimerase, score 1.8e-106"
     gene            complement(19693..20637)
                     /gene="tnp"
                     /locus_tag="SPC45_0021"
                     /pseudo
     CDS             complement(join(19693..19848,19845..20243,20245..20637))
                     /gene="tnp"
                     /locus_tag="SPC45_0021"
                     /note="member of homology group 258"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1672 transposase"
                     /db_xref="PSEUDO:CAI34593.1"
     gene            20864..21118
                     /gene="HG273"
                     /locus_tag="SPC45_0022"
                     /pseudo
     CDS             20864..21118
                     /gene="HG273"
                     /locus_tag="SPC45_0022"
                     /note="member of homology group 273"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyl transferase (fragment)"
     gene            order(21210..21518,21544..21933)
                     /gene="tnp"
                     /locus_tag="SPC45_0023"
                     /pseudo
     CDS             join(21210..21518,21544..21933)
                     /gene="tnp"
                     /locus_tag="SPC45_0023"
                     /note="member of homology group 19; member of homology
                     group 19"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1381 transposase"
     misc_feature    join(21456..21518,21544..21921)
                     /gene="tnp"
                     /locus_tag="SPC45_0023"
                     /note="HMMPfam hit to PF01609, Transposase DDE domain,
                     score 3.7e-15"
                     /pseudo
     gene            22226..23095
                     /gene="rmlA"
                     /locus_tag="SPC45_0024"
     CDS             22226..23095
                     /gene="rmlA"
                     /locus_tag="SPC45_0024"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI34596.1"
                     /db_xref="GOA:Q8RSF0"
                     /db_xref="HSSP:1FXO"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q8RSF0"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSV
                     ALILGDNIYHGPGLSKMLQKAAKKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEK
                     PEYPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    22229..22945
                     /gene="rmlA"
                     /locus_tag="SPC45_0024"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.3e-120"
     gene            23096..23689
                     /gene="rmlC"
                     /locus_tag="SPC45_0025"
     CDS             23096..23689
                     /gene="rmlC"
                     /locus_tag="SPC45_0025"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI34597.1"
                     /db_xref="GOA:Q9AHA9"
                     /db_xref="HSSP:1NXM"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9AHA9"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKNHPLLKDVKPLKKEDL"
     misc_feature    23132..23662
                     /gene="rmlC"
                     /locus_tag="SPC45_0025"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 4.5e-16"
     gene            23702..24751
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
     CDS             23702..24751
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI34598.1"
                     /db_xref="GOA:Q4JYN4"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN4"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLVAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAVD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    23717..24673
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 4e-05"
     misc_feature    23720..24460
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 9e-78"
     misc_feature    23720..24586
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.0044"
     misc_feature    23723..24535
                     /gene="rmlB"
                     /locus_tag="SPC45_0026"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1e-05"
     gene            24817..25668
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
     CDS             24817..25668
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI34599.1"
                     /db_xref="GOA:Q9RQL5"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9RQL5"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    24817..25665
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 1.1e-148"
     misc_feature    24820..25449
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 1.4e-19"
     misc_feature    24820..25461
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 9.3e-05"
     misc_feature    24823..25551
                     /gene="rmlD"
                     /locus_tag="SPC45_0027"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 1.4e-08"
     gene            order(25744..26695,26712..26927)
                     /gene="tnp"
                     /locus_tag="SPC45_0028"
                     /pseudo
     CDS             join(25744..26484,26483..26695,26712..26927)
                     /gene="tnp"
                     /locus_tag="SPC45_0028"
                     /note="member of homology group 12"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS1670 transposase"
     misc_feature    25750..26193
                     /gene="tnp"
                     /locus_tag="SPC45_0028"
                     /note="HMMPfam hit to PF03050, Transposase IS66 family,
                     score 2.1e-05"
                     /pseudo
     gene            27226..>27591
                     /gene="aliA"
                     /locus_tag="SPC45_0029"
     CDS             27226..>27591
                     /gene="aliA"
                     /locus_tag="SPC45_0029"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI34601.1"
                     /db_xref="GOA:Q4JYN2"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4JYN2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSSSTKGEKTFSYIYE
                     TDPDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIR
                     KDAKWYTSEGEEYAAVKAQD"
     misc_feature    27226..27318
                     /gene="aliA"
                     /locus_tag="SPC45_0029"
                     /note="Signal peptide predicted for SPC1993 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.703 between residues 31 and 32"
     misc_feature    27478..27546
                     /gene="aliA"
                     /locus_tag="SPC45_0029"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     8920 a   4191 c   5578 g   8902 t
ORIGIN
        1 cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact tgacagtaga
       61 aggaaaagtc aaatctgtct tgattgaaaa caccctagct caagaagtct ttgaaaaaca
      121 aatcttagtt ccatgggatg ctttctgtgt ggaattacta taaatatttt ttgcagaaaa
      181 atttaaaatt gaaatcatat aaaaacaagg gaggactgta taaaaagcag aaatcctttg
      241 ttttttataa ccaaggttta taaactttca ttctcgaaat tcaattaact ttacaaattc
      301 ccactattaa ggagaaagaa gatgaacata aagaagcgtg tccttagtgc aggcctgact
      361 tttgcatctg ctttgctttt agctgcttgc ggccaatcag gttcagatac aaaaacttac
      421 tcatcaacct ttagtggaaa tccaactaca tttaactatc tattagacta ttacgctgat
      481 aatatagtca attgaaacaa gaacaagaca aaagagcctc ataaaaggta ttgcaacttg
      541 gtaatacctt tttgaggtgc tttttgatat gagcccatgt tttctcaata ggattgtact
      601 caggtgagta gggaggaaga ggtaaaagtt tacgcctaaa ctcttcacac aagagttcta
      661 gcttccccat tctatggaat cttgcattat ccataataat aaccgatggt gtgtttaatg
      721 ttggtaagag aaacttctga aaccaagctt caaaaaagtc gctcgtcatc gtctcttcgt
      781 aagtcattgg agcgattaac tcaccattca tttgttagac ctgcaaccaa agaaatcctc
      841 tgatatcttc ttccagatac tttgcctctt attaactgac tttttaatga gcgaccatat
      901 tctcgataaa aataagtatc gaatcctgtt tcatcaatct aaacaggtgc taggtgcttt
      961 aaactattaa aattcttaag aaataaggct actttttctg ggtcttgttc atagtaggtg
     1021 tggttctttt ttcgagtgta gcccatagct ttgagcgcat agtggatggt agttggatga
     1081 cagccaaatt cagaagctat ttcagtcaaa taagcatctg gattgtcagt aagatagttt
     1141 ttaagtctat ctctatcaac ttttcttggt tttgttcctt ttacttggtg gtttagctct
     1201 cctgttttct cttttagctt taaccagcca taaatggtat tacgtgagat ttggaaaacg
     1261 tgtgatgctt ctgttatact acctgttcgc tcacaataag agagaacttt tttacgaaaa
     1321 tctattgaat atcccataag aagattatac cacattgtgt actatagtag attgaaacta
     1381 gaatagtaca cctctacttc taaaacattg ttagaaatcg atttgactgt cctgatcgat
     1441 ttgtcatgtt cttatttcat tttactatat ttttggttcg cgggaagtct actaagatac
     1501 ttaaagatgc agatagtgaa aataaaggtg tagacattac cgtaaaaaag tgatataatc
     1561 gtatgatgtt gaatgtatag gtgttaatca tgagtagacg ttttaaaaaa tcacgttcac
     1621 agaaagtgaa gcgaagtgtt aatatagttt tgctgactat ttatttattg ttagtttgtt
     1681 ttttattgtt cttaatcttt aagtacaata tccttgcttt tagatatctt aatctagtgg
     1741 taactgcgtt agtcctacta gttgccttgg tagggctact cttgattatc tataaaaaag
     1801 ctgaaaaatt tactattttt ctgttggtgt tctctatcct tgtcagctct gtgtcgctct
     1861 ttgcagtaca gcagtttgtt ggactgacca atcgtttaaa tgcgacttct aattactcag
     1921 aatattcaat cagtgtcgct gttttagcag atagtgagat cgaaaatgtt acgcaactga
     1981 cgagtgtgac agcaccgact gggactgata atgaaaatat tcaaaaacta ctagctgata
     2041 tcaagtcaag tcagaatacc gatttgacgg tcaaccagag ttcgtcttac ttggcagctt
     2101 acaagagttt gattgcaggg gagactaagg ccattgtcct aaatagtgtc tttgaaaaca
     2161 tcatcgagtc agagtatcca gactacgcat cgaagataaa gaagatttat accaagggat
     2221 tcactaaaaa agtaggagct cctaagacgt ctaagaatca gtctttcaat atctatgtta
     2281 gtggaattga cacctatggt cctattagtt cggtgtcgcg atcagatgtc aatatcttga
     2341 tgactgtcaa tcgagatacc aagaaaatcc tcttgaccac aacgccacgt gatgcctatg
     2401 taccaatcgc agatggtgga aataatcaaa aagataaatt gactcatgcg ggcatttatg
     2461 gagttgattc gtccattcac accttggaaa atctctatgg agtggatatc aattactatg
     2521 tgcgattgaa cttcacttcg tttttgaaat tgattgactt attgggaggg gtagatgttc
     2581 ataatgatca agagttttca gctctacatg ggaagttcca tttcccagta gggaatgtcc
     2641 atctagactc tgagcaggct ctaggttttg tacgtgaacg ctactcacta gccgatggag
     2701 accgtgaccg tggtcgcaac caacaaaagg tgattgtggc tatccttcaa aaattaacgt
     2761 caaccgaagc actgaaaaat tatagtacga tcattaatag cttgcaagat tctatccaaa
     2821 caaatatgcc gattgagact atgatagatt tggtgaatac tcagttggaa agtggaggga
     2881 attataaagt aaattctcaa gatttaaaag ggacaggtcg gatggatctt ccttcttatg
     2941 caatgccaga cagtaatctc tatgtgatgg aaatagatga tagtagttta gctgtagtta
     3001 aagcagctat acaggatgtg atggagggca gatgaaatga tagacatcca ttcgcacatc
     3061 gtctttgatg tagatgatgg tcccaagtca agagaggaaa gcaaggctct cttggtagaa
     3121 tcctacaggc agggggtgcg aaccattgtc tctacctctc accgtcgcaa gggcatgttt
     3181 gaaactccgg aagagaagat agcagaaaac tttcttcagg ttcgggaaat agctaaggaa
     3241 gtggcgagtg acttggtcat tgcttacggg gctgaaattt actacacacc agatgttctg
     3301 gataagctag aaaaaaagcg gattccgacc ctcaatgata gtcgttatgc cttgatagag
     3361 tttagtatga acactcctta tcgcgatatt cataacgcct tgagcaagat cttgatgtta
     3421 ggaattactc cagttatcgc ccacattgag cgctatgatg ctcttgaaaa taatgaaaaa
     3481 cgcgttcgag aactgatcga tatgggctgt tacacgcaag taaatagttc acatgtcctc
     3541 aaatccaaac tttttggcga acgttataaa ttcatgaaaa aaagagctca gtatttttta
     3601 gagcaggatt tggtccatgt cattgcaagt gatatgcaca atctagacgg cagacctcct
     3661 catatggcag aagcatatga ccttgttacc caaaaatacg gagaagcgaa ggctcaggaa
     3721 ctttttatag acaatcctcg aaaaattgta atggatcaac taatttagga gaaatgatga
     3781 aagaacaaaa cacgatagaa atcgatgtat ttcaattagt taaaagcttg tggaaacgca
     3841 agctaatgat tttaatagtg gcacttgtga caggtgcggg ggcttttgca tatagcactt
     3901 ttattgttaa gccaaaatat acgagtacca cgcgaattta cgtagtgaat cgcaatcaag
     3961 gagacaagtc ggggttgaca aatcaggatt tgcaggcagg atcttatctg gtaaaagact
     4021 accgtgagat tatcctttcg caggatgttt tggaggaagt tgtttctgat ttaaaactag
     4081 atttgacgcc aaaaggtttg gctaataaaa ttaaagtgac agtaccagtt gatacccgta
     4141 ttgtctctgt ttcagttaat gatcgagttc ctgaagaggc aagccgtatc gctaactctt
     4201 tgagagaagt agctgctcaa aaaattatca gtattactcg tgtttctgat gtgacaacac
     4261 tggaggaggc aagaccggcg atatcaccgt cttcgccaga tattaaacgc aatacactaa
     4321 ttggtttttt ggcaggggtg attggaacta gtgttatagt tcttcttctt gaacttttgg
     4381 acactcgtgt gaaacgtccg gaagatatcg aagatacact gcagatgaca cttttgggag
     4441 ttgtaccaaa cttggataag ttgaaatagg agagaggaat gccgacatta gaaatagcac
     4501 aaaaaaaact ggagttcgtt aagaaggcag aagaatatta caatgccttg tgtacaaata
     4561 tacagttgag cggagataaa ctaaaagtaa tttccgttac ttctgttaac cctggggaag
     4621 gaaaaacaac tacttccgta aatatagcaa tatcgtttgc gtgtgcaggc tataaaactc
     4681 ttttgatcga tggtgatact cgaaattcag ttatgtcagg attttttaaa tctcgtgaaa
     4741 aaattacagg gctaacagaa tttttatctg ggacagctga tttatctcac ggtttatgtg
     4801 atacaaatat tgaaaattta tttgtagttc aatcgggaac tgtatcacca aaccctacag
     4861 ccttgttaca aagtaaaaat tttaatgata tgattgaaac attgcgtaaa tattttgatt
     4921 atatcattgt tgatacagca cctattggaa ttgttattga tgcggcaatt atcactcaaa
     4981 agtgtgatgc gtccatcttg gtaacagcaa caggtgaggt gaataaacgt gatatccaaa
     5041 aagcgaaaca acaattaaaa caaacaaaga aactgttcct aggagttgtt ttaaataaat
     5101 tggatatctc ggttgataag tatggaattt acggttccta tggaaattat ggtaaaagat
     5161 aaaatgaata tagtatggaa ggggactaca gtataactct ggcattctta cagagcatac
     5221 ttatcagttt attagcttat gtactgattg caatttcaga aaccgatatg tcttcaaata
     5281 atattcggtc tatttggaag aacaattgaa ctgaaccttc taattcatta ttgagaactc
     5341 atatattact gaaacaaata aattttgttt agatggagaa aagttttatc tgacgtagag
     5401 gataaaagaa ttatatttct gaaaatcatt gagtgaccaa atatatattg agtttctgta
     5461 gttgcatgta ctgcctgatt taatttgtca aatggaaata gaatgaaaaa tggaaataga
     5521 atttatagtt ggaggttgtt tatgtacagt ataataaaac gattaggtga tatattatta
     5581 tctttaatag ggataataat attgtgtccg gtttttatga taattgcaat tgcgattaaa
     5641 cttgattcag aaggtccggt tatatttaag caaaaacgct ttggtattca taaagaatac
     5701 ttctatattt tgaaatttag gtctatgaaa atagatgcac ctaaaaatgt ggcgcctcga
     5761 aacttatata atccagagca atggattaca aaagtagggg ctttcttgcg aaaaacatct
     5821 ttggatgaac taccacaatt gtttaatatt cttgttggta atatgagtat tgtaggtcct
     5881 agaccagcgg gtataaatga actagatttg attgcagaga gagataagta tggagcaaat
     5941 gatatcttgc cagggttaac tggatgggca caaattaacg ggcgtgatac tttgtctgtt
     6001 gagatgaaga cggagttaga tggctactat gttaaacatc tgtctttgat aatggatatt
     6061 agatgtatag ttaagacaat accttacgta ctgaaacgaa aaggtattgt agagggtagt
     6121 ggtaagaaag aaagttaaat tggacaatga aaatactatt tgtttgccaa cattataagc
     6181 cagaaccatt caggttgtca gatatttgtg aagatttagt tcgaaaaggg catgaagtct
     6241 ctgttttggc tgggattcct aattaccctg aagggaagat atatgcagat tatcgtcata
     6301 ataaaaaaag acgtgagatt atagaaggtg ttacgatata tcgttcttat acaatcccta
     6361 gaaaaaaaag tgttgtattt cgattgttga attattttag ctttgcaatt agttctactt
     6421 taggagtttt attggggagg tataaaacga aagatggatc gaattttgac tgtgtattcg
     6481 ttaaccaatt gtctccagtt atgatggcat gggctggtat ggcttataaa aaaaaatata
     6541 agaaaccgat gtttctatat tgtatggatg tttggccaga tagtttaacc gtaggtggag
     6601 tgaaacaaga tggcttgatt ttcaagctgt ttaaatttat ctcaaaaaaa gtttaccgag
     6661 ctagtgatta tatatttgtc actagtccat catttaaaaa ttattttgtg aagcaatttg
     6721 acatatccga acaaaagatt acatatttgc cacaatatgc agaagatctt tttatccctg
     6781 atgaatctat agttaataaa gaaagtgttg acctaacttt tgctggtaat attggcaaag
     6841 cacaaaattt ggaaactatt ttgaaagctg ccagtttgat agagaagaat accaatttac
     6901 ccaagaaaat tcattttcat tttgttggag atggtacgga attgttaagc atgaaagcat
     6961 tagctcatga attggagtta aagaatattt ccttctatgg aagacgttct ttggaggaaa
     7021 tgccatcctt ctataaaaaa tcagatgcta tgttagtttc tttaatagga gactcgatag
     7081 tttctcgtac tatacctggg aaggtacaat cttatatggc ggcaggcaaa ccaattatag
     7141 gtgcaatttc aggagatgct aaaataattg tagaagaagc aaattgtgga tatgttagtc
     7201 ccgaacgaga tgtaaaacaa ttggcaaaaa atatttgtaa atttagtatg ttatctatta
     7261 agagacaaag agagttagga aagaaagctc gttgttacta tgaaaatcac ttttcaaaag
     7321 agcagtttat gacacagtta gaaaagtatt tgagagagga attttcctca tgaaaatttt
     7381 gatgattaat actgtttgtg gtattaggag tacaggaaga atttgtacgg atatcgcaac
     7441 cgctttaaca aagaagggtc atgaagttaa gattgcatat ggacgtgagt atgttcctac
     7501 acagtatcga aattacgcgg ttaagatagg gtctagagtg gatgtaaata ggcatgtctt
     7561 acaagctcga atttttgata atgctggttt tgtaggtaga gcagcaacta gaaaatttat
     7621 cacttgggtg aaagaatatg atcctgatat tattcatctg cataatttac atggatacta
     7681 tattcatgta ggagagttat tttcctattt gaaaacttgc ggaaagaaaa ttttatggac
     7741 tttacatgat tgttgggctt ttactggaca tggtgcttac tttgatactt tagaatgtga
     7801 aaaaattgga cagtgccatc attcgagtca aaaaaatgat tatccaaagt cattaattga
     7861 tttttcatct agaaatttta aacgtaaaaa aaatttgttt acaggtgttc caaacttgac
     7921 acttattaca ccatcagagt ggttggcaaa tttggtaaga aattcatttt tgaaagaata
     7981 tcccgtaaca gtcattcata atggtattga tactacgata tttaaaccaa gggtattaga
     8041 ggctaagaaa ctgagaaaaa aatttcgctt agaaggaaaa caggtattgc ttggtgtggc
     8101 ttctatctgg gatcagcgta aaggattgga tgatctatta gaattatctg tacagctaaa
     8161 atcttatcaa caattagttt tgataggatt atcaaaagaa caattgaata aacttcctaa
     8221 agagattatt ggtctgacca caacagatag tgtagaagaa ctttctgctt ggtacacgtt
     8281 ggcagatgta tttatcaacc caacaacaca ggataattat cctacaacta acttagaagc
     8341 tattgcctgt ggaacaccag ttgtgaccta cccaactggt gggagtatag aaagtacata
     8401 tatgtatggt atagtgtgta gtgatagaac agttgtttct atattagagt ccctaaaaga
     8461 agtgagtcaa tgtaaaagga gtcctaattt taatttgtca aaagagtatt ttgtggaaaa
     8521 tatactcaat ttatactagt ggaactggag ttgatatgat aaaaatttta tatgttaacg
     8581 gcgggactat ggatagaggt ggtgtatcta cttttatgat gaatgtttat gaaaaaatgc
     8641 attctgaaaa aattcaaatt gattttttag tccatacctt atccgaaggt gtacgcgatg
     8701 aggatatttt aaatcttgga ggtaaaatct ttagagttcc tgctagagga aagaatcctc
     8761 taaaaaatta tcgccaaatt aaacaaatta tgttgaatgg aaattatgat gtagttcatg
     8821 cgcatgctga tgcaggaaat aggacaattt tatctattgc aaaagagtgt gatattccta
     8881 ttcgtatttc acattgccat aatacaaact atacaaacaa aagtttatta aagaagtttt
     8941 tgaatgagca attcaagaag caaattccga gatatgctac tcatctatgg gcttgttcag
     9001 aaaaagcagg agagtggttg tatgggaatc actcttttga agttattcct aatgctattg
     9061 atgttcaaaa gttcatctat agtccacaat tatctaaaga tttacgtaag gaattaaatt
     9121 tagaaaataa gtttgttatt ggtcatgtag gacgatttga ttatcagaaa aatcatgatt
     9181 ttcttcttaa agtttttacg gaatttatca atgaaagaga agatgctcat cttgttctca
     9241 taggtaaggg agaattggaa gaggttatta aaaagcaagc aaatcactta ggaatattgg
     9301 ataagattag ttttttaggc gagtcttcta atgtgaatga actgattaat gtgtttgatg
     9361 taggtgtttt cccatctctt tttgaaggtt ttagtatagc tatggtagag atgcaagtca
     9421 acggtttacc attagtggtt tctgataatg ttccaagtga gattaattta actgataata
     9481 tacgtttttt atcactggat gaaacagtta aatattggtg taaaacgatt ttggagacca
     9541 aaggacggga tactggggca gttgataaaa ttattgctaa gggttataac ctgtctgata
     9601 tggttcataa gttaacaaaa acttatgaaa gaattgtaga taaatcatga aaaaagtatt
     9661 atttgtaact aatattccat caccttatcg tgtggatttc tataatcaac ttgggaaatt
     9721 tgtagattta actgttgttt ttgaagcaac aggagctcaa gatattagat ttgattaccg
     9781 agagattttt aaaaatttta ccgccatttt tttaagtgaa ggtaatattg atgagaagaa
     9841 attaaattca gctatatttc agtatttaat tcctaaaaaa tatgactata tttttttgac
     9901 taactattct tatcgaacag aattatttgg ttatttaaag tgtgtttttt ctaagatacc
     9961 gtttgtatta gaaattgatg gtggtaagat accagaaagc gagaattttt taaaatacca
    10021 gtttaaaaaa tttattctta cgaaacccta ctattatttt agcccaagtc agtccagtga
    10081 tgatttctta gcgcattatc atgtgaataa agaaaatatt tatcggtatt catttacttc
    10141 cttatcagag aaagacatac gatatcaaat tgtcgatgag aaagaaaaac aatttttaag
    10201 aaagaaactg ggattcagtc caactaagaa aacaatttta tttgttggta gaatcatccc
    10261 tggtaaaggt gtggatgttc taatcaaggc tgttcagaat ttatcagacg atgtacaatg
    10321 tttaattgta ggcccaagtc ccgatagtga atacaaacaa tacttgcttg atcttattgg
    10381 acaagatagc cgttttcatt ttattgattt tttacagaca tctgaactga aacaatacta
    10441 caagctatct gatatatttg ttttaccaac aaagtcggat gtttggggac ttgttgtaaa
    10501 cgaggcaatg tctcagggac ttcctgttat ttctacatct gcatgtgttg ctgcaattga
    10561 gcttgtttcg aatggtaaca atggatatat tattgatagg gttgatgact ggaaagctat
    10621 ttttcaaaag ttaagcaaag tattacagga tgactcgtta cgagttcaat tatctcaaaa
    10681 tgctttatct actattaaac actacactat tgaaacaatg gttaaagagc atttgaaatt
    10741 tatggaggaa aaatgaggat atctgttgcg atgacaacct ataatggagc agattatttg
    10801 ctagagcagc tagaatcgct tcgcactcag agtttaatgg ctgatgaagt tattattgtt
    10861 gatgattgtt caacggataa tacagttgag ctacttgata tgtatattca gaagtatcat
    10921 ctcgataatt gggtattgat tagaaactca tctaatatag gttggagaaa aaactttaga
    10981 aaagctcttc aagagacaac aggagatata gtttttcttt gtgatcaaga tgatatttgg
    11041 aacaaagata aaatttcact gatggtaaaa gagtttcata aatcgccgtc aatagaacta
    11101 ttggctagta actatgagat tctcgatttt ggcagaaatg ataaaatcaa gattagggat
    11161 gttgagttag ataatggtgc tgtagttccg ttttcgttaa aaaacaagag tatttctgtt
    11221 atgagaccag gatgtacttt tgcagttaag cgtgagttaa tagttctgtt agaaaagtat
    11281 gatatagata gatttggcca tgataatatt ttatggaatc tagctatgat aagaggaact
    11341 ctatatctat acttaaaacg cttaatacat tttcgtcgcc acgagacaag tgcttctgct
    11401 cctaaccaat ctcttaatcg tgaccggcga gttgttgaag tggatacgag tcatcaaatt
    11461 acagttttct tacttgatgc ggctcgtaga gaacatttag acataaaaat aatttctcag
    11521 cttgaaaata tggaaatggt tcttgagaga cgtagagata ttttaaaata tggtactctt
    11581 atgcaaatag ttcatttcca actgaagtat catacttatt atcctacatt ccgcaattta
    11641 ttatcggata tattagtgtt tttgaaaaaa taatgagaga gaagagtttt gagcaaaatt
    11701 tctaaaaatt atctatataa cttaatttat caagtggtag ttttaatatt gccactattg
    11761 attactccat atgttgctag aatattaggc gcacaccagt taggaattta tgattatgtc
    11821 aattcaatcg ttactttgat ttacacttta ggtttattag gtattggtca ctatggaaat
    11881 cgcgaatgtg cctatactag agatgataaa gaggaactat cagagacatt ttggagtatt
    11941 ttagctattc agattattct aggatttttt tcactgttat tcttgtatat tttttctaac
    12001 ataaattcaa attatcaagt ttactttcag cttttctcta tttggctttt tgggtctatt
    12061 cttgattgta cttggctcta tcgtggctta gaggaaatgc agtatgttgt gttaaaaaat
    12121 attattgcta agttattatt tacgatagcg accttcttat ttgtaaaaag tgaaacagat
    12181 ttaactctat atgtgctcat atatggtctc tctgttttag tagccaattt atcaacttat
    12241 agtcaactaa ggatgtttat tagtagacca aagataaata ttaatcgttt tacggagatt
    12301 attttaggga gtctcaaact atttttacca agtatcatca cgcaaattat gttatctgct
    12361 gataaaattg ttctagggtc tttaagttct ggaatcagca atgtttctta ctatagtaat
    12421 gcagagaaga ttatacagat accactctct ttaatagtag tattaaattc tgttatgatg
    12481 ccccgaatag caaatgaatt tcgtaataga cggttagaaa atatgaaaaa gtatctgaca
    12541 actgcagctg aattttcttt gttcttagct gttccattgt cgattggcct ttatgctatt
    12601 gcagatactt ttgttccgtg gtttttaggc gaaagtttta tgccatctat ggatgctctt
    12661 aaatggcttg ctcctattgc tgttggcaat gctttgctag gagtctcagg tagtcagtat
    12721 tttgttgcag ttaataaaac aaaagtctta tttttttcta atactttagc tgcaatttta
    12781 aatattctat tagatttgtt acttgctcca atgtttggag tagtaggggt ttgtttagca
    12841 actatagtat cacttacctc ttctgttata gtgcaatact atataatgtc aaaggatata
    12901 cctattatac ctattttgaa gtcattattt aaatatctca tttattctat gataatggga
    12961 atgattatta ttgtttcatt cagaggatat ccagcaaatt atagaacaac tattaagcaa
    13021 atcgttcttg ggatagtagt ttactttggt ttgaacttgt tgacacgaga tgtatttgtt
    13081 tttcaaacat tagattttgt aaagaaagga ttcaaaaaaa gtagatgatt tcagctttat
    13141 tttatataag ttttttaaca aatctattag tcgttgtcaa taggatgcgt ataaattccc
    13201 tagcattttt atcttggtta attttgtttt ttatctatgc aggaaatatc cgagaaggat
    13261 tttcagattt aattcattat cgtgcaagat atgctgtagg gaaaagtagt ctgtattttt
    13321 cagaccatgc gtataatttt tttgcagatt ggttttcaca tcactccatc tcttttcaag
    13381 tttttttagc atgtattttt ctattctcct cagcatgttt ctattttgtt gctaaaaaat
    13441 tgcattgtaa ttataatctt ctgattttat tattatctct tttttatttc ttttatactt
    13501 tagaagttct aaggttcttt ttagcaacta gtgtagcact tatagcacac tattatcttt
    13561 cacaaaatca tcgattcata ttcataggat tgatgttcat agcgtttctg tttcacggat
    13621 ctatcattta tttcttacca tttattattt tttatagaca aaaaaatact agtaagatgc
    13681 tatgggcatt ggtatttata tctatggtgt taattgtgac aaatctattg gtaggtaata
    13741 attctagcta cttgactaaa atatttgaac tgctagggag cgaggtcact aaaagtcgtg
    13801 ttatgtatta tacagcgaaa tcgactcgtc ttggttttat attgtatgat agttactata
    13861 ttttcaacct actaattagt attaacctta aaaagattgc aaaaacagtt tcaaatgcac
    13921 ctcaggaagt gaccaatttt ataaatctgg tgtatcaaca tagttttttt agtacaattt
    13981 ttttaccact aattatgttt agtacagcat ttactcgcta tttaattttt actgttgttt
    14041 taaattttat agctattgca gctttacaac catttatgca acaatcattt ataaaattaa
    14101 agagtgggct ttatattatt ttcggagttt taggtgctac ttgtttttgg tggtatctaa
    14161 gagaaaatgt cctttatttt tatgaggcac ttttgccaaa tttatttaac tgattttata
    14221 ttctttatgt ctgtactttg caaacattac aagagtggtc tataatataa aaatataaag
    14281 aaatacggta tagctatttc tttagaaagt ggaaatttaa atgattaatt acagcgcaga
    14341 tgaattagac atgattcaga agcttgaact caaaatatta aaagaaatta ttcgaatatg
    14401 taaaaaagaa aagatagagt attttttaat tggtggaagt gctcttggag caatacgtca
    14461 tgaaggattt ataccatggg atgacgatat tgatgttggt atgacacgtg agaattatga
    14521 taactttttg agagtagctg aacagtattt aggagaagag ttttatttac aatcaccctc
    14581 ctctgataga aaatcaccct attcttacag taaactaatg ttaaaagaga ctttgttctt
    14641 agagtatgcc caaaggaatt taaaaacaca aagtggtatt tatgtagata tttttccatt
    14701 tgatgaggtt ccagataatg agtcagaaaa tgagagacag tttaaagcgg tacagtttta
    14761 taaaaagtta tatgtgatga ggatgttgcc aactgtttct aaggctcctg agaatttgat
    14821 tcaaggttta aaagctattc taaggagatg cattcattat agtttaagat taatccctaa
    14881 aagtttaata ctcaaaaaaa ttgatcaatt ttctagatta tataatggaa caaatcaatc
    14941 tgcattggct tgtttagatt ttccggtaag aaatgtagag tatgttctaa aaacaacact
    15001 atatccctta attgaacata aatttgaaga aatcacaatt ttattacctg gtgattttca
    15061 tcaatacttg actacacatt atggtgagta catgaagttg ccacctttag aagaacgtgt
    15121 tgggcataga ccatatttga ttgatttagg aacatatgga aaggaagaaa aatgaagaga
    15181 gtgattactt acgggacttt tgatttgctt cattacggtc atatcaattt attgaagcgt
    15241 gctaaagatt tgggagatta tttaatagta gctctatcta ctgatgaatt taatcttcaa
    15301 aaagataaga tttcatattt caattatcaa cagcgtaaaa ttttgcttga atctattcgt
    15361 tatgtagatc tggtaattcc tgagatttca tgggaacaaa aacgagaaga tgtaaagaaa
    15421 tattatgctg atatctttgt tattggtgat gattgggaag gtaagtttga ttttttgaaa
    15481 gatgaggggg tagaagtagt atatttacct cgtactaaag aaatttctac tacacagata
    15541 aaagaagact taaacaagac caaaggtgga aaataatatg tcacaattta caggaaaaac
    15601 tcttctaatt acaggaggga caggttcatt tgggaatgcg gttctcaagc gttttttaga
    15661 aacagatatc tcagagattc gtatcttttc gcgagatgaa aagaaacaag atgatatgcg
    15721 tcatgagttt caggtaaaag taccagaagt ggctgggaaa atccgttttt acctcggaga
    15781 tgtgcgtgac ttagcttcgg taaaaaatgc tatgcatggt gtggattatg tttttcatgc
    15841 tgctgctctg aaacaggtac cttcttgtga atttttccct gtagaagcgg taaaaactaa
    15901 cattttggga acggagaatg ttctcgctgc agctatcgaa gctgatgtaa agcaagttat
    15961 ctgtctttct acagataagg cggcttatcc tgttaatgct atgggaacgt ccaaggctat
    16021 gatggaaaag attgctgttg ctaagtcccg ggcggtaaat cctgagcata caaagatatg
    16081 tgtgactcgc tatgggaatg ttctatgtag ccgaggatct gtagttcctc tttggattga
    16141 gcaaattaag caaggaaatg ctcttacaat tactgaacct agcatgacac gttttgtgat
    16201 gacattggaa gaagcagtag atttagtttt atttgcattt gaagaaggga aatctggcga
    16261 tatactagtt cagaaagcac cagcatgtac gattgaagtt ttggctaagg ctgtatcaga
    16321 aatttttgcc tcagaacaag atattaagat tataggtatt agacacggag aaaaaatgta
    16381 tgaaacacta ctaactaatg aagagtgtgc aaatgcaatt gatttgggta atttttatag
    16441 agttcctagt gataatcgta atcttaacta tgataagtat ttcaaagatg gtagtacgaa
    16501 tagaaatttg ttgacagaat tcaatagtaa taataccgat ttgatggatg tagagcaagt
    16561 taaaagaaag ttgctagaat tagatgaaat acagacagca attcgtgata tggtagcaga
    16621 tgaagagatg taaaatcttt taagttacat taaaattatc aagtatatat aatgtatcat
    16681 gtattgtcga gagagttgat tattaaaaca gcatataaaa caaggagggg gcatgattaa
    16741 aaatatttta atcacaggag caaaaggatt tgtaggaaaa aatcttatct gtactctgga
    16801 agctttgaaa gatggacgag ataggactcg tcctaattta gagattggag agatttttca
    16861 gtatgatcgt gatacagatc cgattttatt agatgaatat tgtaagaagg ccgatttcgt
    16921 attccattta gctggtgtca atcgtccaca gaatcctgat gaattcatgg agggaaatta
    16981 cggtttttca agtagattat tggagatttt agaaaagtat gaaaacactt gtcctgttct
    17041 actctcaagt tctactcaag ctagtttaga aggccgattt tcaaactcta tatatggaca
    17101 atctaagcta gcaggggaag aactcttctt tgaatatgga aagaaaacgg gagcacctgt
    17161 cttagtttac cgtttcccga atctttatgg gaagtggtgc cgtcctaact acaattctgc
    17221 tgtagcaact ttctgtcata atctagctca cgatttacct attcaagtaa atgatccaag
    17281 tgtagaattg gagttgctgt atattgatga tttgatacaa gagtgtctaa ctgcattgga
    17341 aggaaatcct catcgttgta atctagatgg attacaaatc ttacctagcc cgtcaggaaa
    17401 ctactgctac gtaccaacga ctcatcgtgc aaccttagga gagattgtct ctctattaga
    17461 aacatttaaa aaacagcctg atagtttagt tatgcctgaa attcctcaag gatcgtttaa
    17521 aaagaaattg tattctacct acctatctta tttaccagta gataagttta agtttcctct
    17581 aaaaatgaat atagatgaac gaggtagttt tacggaatta ttaaaaacag aaaatacggg
    17641 tcaattttct gttaatattt ctaaacctgg cattaccaaa gggcaacatt ggcatcattc
    17701 taagtgggaa tttttcatgg ttgtttctgg tcgtgcttta atacaagagc gtaggatagg
    17761 gctggataaa aatggtcaag agtatcctat tctgaacttt gaagtgtcgg gcgataagat
    17821 tgaagcaata catatgatac cgggctatgc acataatatt attaatcttt ctgatacaga
    17881 aaatctagtt actgtcatgt gggctaatga gtcatttgat cctagacatc cagatacttt
    17941 ttttgaacaa gtggagaaat aaatgaaaat taagacaaat tatagtgata ttcactttaa
    18001 agataatggc aaacttaagt tattgattat tgtgggaaca cgtccagaga ttatacgtct
    18061 aagtagtgtt atcactaaat gtcgaaagta ttttgatgtt attttggcac atactggaca
    18121 aaactatgat tacaatttaa atggtatttt ctttgatgat ttagggttag acactccgga
    18181 cgtatacatg gatgctgttg gagatgatct tggtgctact gtagggaata ttattaatac
    18241 ttcatacaaa ttgatgaatc aaattaaacc agatgcttta ttgattttag gggatacaaa
    18301 ttcttgttta tcagctattg ctgccaagcg tttacatatt ccaatttttc atatggaggc
    18361 tggcaatcgc tgtaaggatg agtgcctgcc ggaagagact aatcgtcgga ttgttgatat
    18421 tatttcagat gttaacttag catactctga acatgcacgt aagtatttac atgagtgtgg
    18481 tttacctaaa gagcgcacat atgtaactgg ttctcctatg gcagaagtgt tacataaaaa
    18541 tttatctgcc attgagtctt cagatatcca tgaacgtttg ggattgaaaa aaggaggtta
    18601 tatcttactt tcagctcacc gtgaggaaaa tattgataca gataaaaatt ttatctctct
    18661 ctttacggca attaatcaat tagctgaaaa atataatatg ccaatcttat attcttgcca
    18721 tcctagatca aagaaaaggc tacaagagag cggttttaaa ctagataaac gtgtgattca
    18781 gcatgagcca ctaggattcc atgactataa ttgtttacag atgaatgcat ttgttgtagt
    18841 atctgattcg ggaactttac cggaagaaag tagtttcttt actagtcaag gttatccttt
    18901 tcccactgta tgtattcgta caagtacaga acgtcctgag tccttagata aggcaggatt
    18961 tattttggca ggcattgatg aaaattctct tcttcaagca gttgaaactg ctgttagctt
    19021 ggcagaagat gaggattttg gattaccggt tccagattat gttgaggaaa atgtctctac
    19081 taaagttgtt aagataatac agagctatac agggatagtg gataaaatag tttggcggaa
    19141 aagctgaatt gtatattttt aataaatcaa aatgagatga ttaattctta gtagaacaag
    19201 agtaaaattg aacgtatttg atggaaatgt cttacttgat attcgaggga tagccattct
    19261 atcggatttt tggcttgttt ttgcgcttca tatttgatag aataaagtga cgacacttta
    19321 accatcgaag cgaggtgaga ataatggcag taatttttaa agatgtactt attgaagaga
    19381 agactgaaga agaaaaacaa catattttat ctattttaaa tggtgagtat aacttatctg
    19441 atgatgtaag tcgtagatta agacgactga atgaggaaag taaacgcttg aaagtgttta
    19501 gtaaggagac gcactaattg cctgtcttgt attttattga tgaattgaaa ttaatcagta
    19561 cttcatcatc tattttaaat gatgggaatg ttagaacttt tgattgtgga tatcaagaat
    19621 tgaatgacat ttttttagat atttacaaca aatacaatga agaatcaggc tatgtattgg
    19681 ctattgtaat actcatctgt tttcaaaaag cattctagtc catctccgat taacgatgaa
    19741 ctttatcacc tccttctcca atccttgtat gacatcttga agttgattca tgacatcttc
    19801 cacagtttga aagactttat tcttaaatcc acgtttacga atctctttcc acacttgttc
    19861 aatgggttca tctctggtgt gtatggagga gtaaatgcaa agccaatatt agtcggaatc
    19921 tttaaggtac ttgatttatg ccatatagca ttgtccataa cgagtaaaaa ataatcatat
    19981 ggataagctt gtgaaagctc ttctaaaaag gcgttcatcc actcagtatt acatccacca
    20041 gctattaaga aaaatgattc gcctgtatgg gcatcaacag ctccataaca atagcgaaat
    20101 tctcgtatat agtgactatg gacatgtgga cctactccta ttggagacca acaagatccc
    20161 agtttactga ttctaccgaa accagcctca tcttggtaca tcaagcgaac cttatgaaaa
    20221 cgtctactgg ttttaaaacg ctttcttgtc ttcttgaatt gagattttat ttttagacgc
    20281 gacaatggtt tgagcgtctg ctttcttagg atgttctgga cgtggcataa tatttcgcca
    20341 accatggcgc ttcaacagtt gatagaaggc attacgtgtg taggaacgac ctaactcctt
    20401 tttataagcc tgaaataagg catcaattgt aacaaattct cctgcctctg cagccttcaa
    20461 atggcgagca agaaaggctt tctcttcctc aatcgtcata tatgcatggt tacgaccacc
    20521 acgtgttttt tgaaggagag aatcgagtcc gaactcgtca tattttttta cagttcgcca
    20581 aatcattgtt tgattacagt ctaaaagctc tataatctct ttataagatt tgcccatcag
    20641 acgaaataga acgatttgaa ggcgtttatg atatttagct gtacgagagt cttttaaaag
    20701 tgttttgatg gtttggattt cttctttagt tgatttcata ttactattat acaatgcttt
    20761 tttattttga tctagtataa atcaaaattt tgaattatta ggttttattt cttgtagact
    20821 agtgtcattt tctcttctag ctcagggtaa agagatggga attagcatag attatcttgg
    20881 tgttcacaag gatatccaga aaaagaggat aggttcgctt ttggtgacct ttgcacttcg
    20941 attatcttta actattgact gttggttacc aataaaaggt gttagagttc atgctttaga
    21001 ggatgctgtg gaattctatg aaaaactggg ttttattgtt cctagagata tggtgattaa
    21061 taatagcaaa ccggttacta tgtattttag tagacttcct gcgaaacaaa atatggtata
    21121 gtagttctat gaatgatgaa gcaagtaaac aactaactga tgcatgattt aagcgtcttg
    21181 ttggtgttca gcgtaccact tttgaagaga tgttagctgg attaaaaaca gcttatcaac
    21241 ttaaacacgc aaaaggtgga cgaaaaccta aattaagcct agaagacctt cttatggcca
    21301 ctcttcaata tgtgcgagaa taccgcactt atgaagaaat tgcggctgac tttggtatcc
    21361 acgaaagcaa cttaatccgt cgaagccaat gggttgaagt aactcttgtt caaagtagtt
    21421 ttacgatttc aagaactcct ctcagttctg aggacacgat aatgattgat gcgacggaag
    21481 taaaaatcaa tcgccctaaa aaaagaatta gcgaatgatt ctggtaaaaa gaaatgccac
    21541 gctatgaagg ctcaagcgat tgtcacaagt caagggagaa ttgtttcttt ggatatcact
    21601 gtgaactatt gtcatgatat gaagttgttc aaaatgagtc gcagaaatat cggacaagct
    21661 ggtaaaatct tggctgacag tggttatcaa gggctcatga agatatatcc tcaagcacaa
    21721 actccacgta aatccagcaa actcaagccg ctaacagttg aagataaagc ctgtaaccat
    21781 gcgctatcca aggagagaag caaggttgag aacatctttg ccaaagtaaa aacgtttaaa
    21841 atgttttcaa caacctatcg aaatcatcgt aaacgcttcg gattacgaat gaatttgatt
    21901 gctggtatta tcaatcatga actaggattc tagttttgca ggaagtctag tattgaaaac
    21961 ctaagaaatg gtggaattat gcctcttaca cagttatttg aaacaccctt aggaaatgat
    22021 ttttaattgt atgcaaacaa agtagaattt gcttatttca ttttatgcta aatataatat
    22081 gaaataagtg aatttttata gataaagaag agtttttcta tgtttttaga taataatttg
    22141 aaaaactgtg acgattattt tgcttttaga gcagtataca attaatagga attgaatcta
    22201 aaacaacaaa gaaaggtacc ctactatgaa aggtattatt ctagcaggtg gttcggggac
    22261 acgtttatat cctttgactc gggctgcatc aaaacaactt atgccggttt atgataaacc
    22321 gatgatttac tatccacttt caacattgat gttggctggg attagggata ttttgataat
    22381 ctcaactcct caagatttgc ctcgttttaa agagcttctt caagacggat ctgagtttgg
    22441 gattaaactt tcttatgcag agcaaccaag tccagatggt ttggcacaag cctttatcat
    22501 tggggaagag tttattggtg atgatagtgt tgctttgatc ttgggggaca atatctatca
    22561 cggccctggt ttgagcaaaa tgcttcaaaa agcagccaag aaagagaaag gtgcgactgt
    22621 ttttggctac caagtgaagg atccagagcg ttttggtgtg gttgagtttg atacagacat
    22681 gaatgctatc tccatcgaag aaaagccaga ataccctcgt tcaaactatg cagtgacagg
    22741 actctatttc tatgataatg atgttgtcga aattgccaag agtatcaaac caagtcctcg
    22801 cggagaatta gaaatcacag atgtcaacaa ggcttacttg gatcgtggag acttatccgt
    22861 tgagcttatg ggacgtggct ttgcttggct ggatactgga actcatgaaa gtttactaga
    22921 ggcttcacag tacatcgaaa cagtgcaacg gatgcaaaat gttcaggtag caaacttaga
    22981 agaaattgct taccgtatgg gctatatcag tcgagaagat gtattggctt tagcccaacc
    23041 acttaagaaa aatgaatacg gacagtatct gctccgtttg attggagaag catagatgac
    23101 agataatttt ttcggtaaga cgcttgcggc acgcaaggtt gaagctattc caggcatgtt
    23161 ggagtttgat atccccgttc atggagataa tcgtggctgg tttaaagaaa atttccaaaa
    23221 ggaaaaaatg cttccacttg gatttccaga gtctttcttt gcagaaggaa aattgcaaaa
    23281 caatgtatcc ttctcacgta aaaatgtcct tcgaggcctc cacgcagagc cttgggataa
    23341 gtacatctct gtagcagatg gagggaaagt tctgggttct tgggttgatc tacgcgaggg
    23401 tgaaaccttt gggaatacct atcagacagt gattgatgcg agtaagggaa tctttgttcc
    23461 tcgaggcgta gctaatggct tccaagtttt atcagataca gtgtcatata gctatctggt
    23521 caatgattac tgggctcttg aactcaaacc caagtatgcc tttgtgaact acgctgatcc
    23581 aagccttggt attgaatggg aaaatattgc agaagcagag gtttcagaag cagataaaaa
    23641 tcatccacta cttaaggatg taaaaccttt gaaaaaagaa gatttgtaaa aaggaaagaa
    23701 tatgactgaa tacaaaaata ttatcgtgac aggtggagct ggctttatcg gttctaactt
    23761 tgtccattat gtttacgaga actttccaga tgttcatgtg acagtcctag ataagttgac
    23821 ttatgctgga aaccgcgcga atattgagga aattttaggt aatcgtgttg agttagttgt
    23881 tggtgacatt gctgatgcgg agttggtaga caagttggtt gctcaagcag atgctatcgt
    23941 tcattatgca gcggaaagcc acaatgataa ttcgctcaat gatccatcgc catttattca
    24001 tactaacttc atcggaacct atactctttt agaagctgct cgtaagtatg atattcgctt
    24061 ccaccatgta tcgacagatg aagtttatgg ggatctccct ttacgcgaag atttgccagg
    24121 tcatggtgaa ggaccaggtg agaaatttac tgctgaaaca aaatacaacc caagctctcc
    24181 gtactcatca accaaggcag cctcagattt gattgtcaaa gcctgggtgc gttcttttgg
    24241 agtcaaggca acgatttcca actgttcaaa taactacggt ccttatcaac atattgagaa
    24301 gtttattcca cgacaaatca ccaatatctt gagcggtatc aagccaaaac tttacggtga
    24361 aggtaagaac gttcgtgact ggattcatac caatgaccat tcttcaggag tttggacaat
    24421 cttgacaaaa gggcaaatcg gtgaaaccta cttgattggg gctgatggtg agaagaacaa
    24481 taaggaagtt ttggaactta tccttaagga aatgggacaa gctgtggatg cctatgatca
    24541 tgtgactgac cgtgcaggac atgaccttcg ctatgcgatt gatgctagca agctccgtga
    24601 tgagttgggg tggaaacctg aatttaccaa ctttgaagct gggctcaagg caacaatcaa
    24661 gtggtataca gataaccaag aatggtggaa agcagaaaaa gaagctgttg aagccaatta
    24721 tgctaagact caggagatta ttacagtata aaaagcagga aatagctgct ttttattgct
    24781 atattgggaa gagttacata ttagaaaggt ctagagatga ttttaattac aggggcaaat
    24841 ggccaattag gaacggaact tcgctattta ttggatgaac gtaatgaaga atacgtggca
    24901 gtagatgtgg ctgagatgga cattaccgat gcagaaatgg ttgagaaagt ttttgaagag
    24961 gtgaaaccga ctttagtcta ccactgtgca gcctacaccg ctgttgatgc agcagaggat
    25021 gaaggaagag agttggactt cgccatcaat gtgacgggga caaaaaatgt cgcaaaagca
    25081 tctgaaaagc atggtgcaac tctagtttat atttctacgg actatgtctt tgatggtaag
    25141 aaaccagttg gacaagagtg ggaagttgat gaccgaccag atccacagac agaatatggc
    25201 cgtactaagc gtatggggga agagttagtt gagaagcatg tgtctaattt ctatattatc
    25261 cgtactgcct gggtatttgg aaattatggc aaaaacttcg tttttaccat gcaaaatctt
    25321 gcgaaaactc ataagacttt aacagttgta aatgaccagt acggtcgtcc gacttggact
    25381 cgtaccttgg ctgagttcat gacctaccta gctgaaaatc gtaaggaatt tggttattat
    25441 catttgtcaa atgatgcgac agaagacaca acatggtatg attttgcagt tgaaattttg
    25501 aaagatacag atgtcgaagt caagccagta gattccagtc aatttccagc caaagctaaa
    25561 cgtccgctaa actcaacgat gagcctggcc aaagccaaag ctactggatt tgttattcca
    25621 acttggcaag atgcattgca agaattttac aaacaagaag tgagataagt agtagaatga
    25681 ttttctagtc taataaaaga ggcagataat gaactccaaa ggagcttaag atgtacgatt
    25741 atcttgttgt tggtgctggt ctctttggcg catagctttg gctcagtttc tattatcgct
    25801 cacaccatcc atcagaagtt taatctgaag gtacccaatt atcgccaaga agaagattgg
    25861 gctaggatgg gtttaccaat cacacgtaag gaaatctcta attggcatat caaggcaagt
    25921 caatactatt tagagtccct ttataacctt ttacgagaaa agttgttaga acaacctctt
    25981 cttcatgcgg atgaaacctc ttatcgggtt ctagagagtg atagccatct gacctactat
    26041 tggacctttt tgtctgggaa agctgagaat caagcaatca cgctgtacca tcatgatcag
    26101 agtcggagtg gttcggtagt acaagaattc ctaggagatt attctggcta tgttcattgt
    26161 gatatgttgc ggcagtaact taggacttta gtcctctagt tctgcctatg cgatagcagt
    26221 ccaaggttta ggagcaaggc gacgctaagc ttggtaaact gcgaaccgct agaagcttat
    26281 cgtcaactgg aagaagctgc acttgttgga tgttgggcac atgtgagaag gaagtttttt
    26341 gaagcgaccc ccaagcaagc ggataaatca tcgttaggag ctaaaggttt agcttattgt
    26401 aatcagttat tttccttgga aagagactgg gaggctttgc cagctgatga acgactacag
    26461 aaacgtcaag aagagctcca acctaatgga agacttcttt gcttggtgcc ggcgtcagtc
    26521 agttttatcg ggttcaaaac taggaagggc aattgaatac agcctcaagt atgaagaaac
    26581 ctttaagact attttgaaag acggacatct ggtcctttcc aataatctag ctgaacgcgc
    26641 cattaaatca ttggttatgg gacggagtaa aagagtccag tggactcttt tagcctaagc
    26701 taaattttaa aaagcgaggg tggttatttt ctcaaagttt tgaaggagct aaagcaagaa
    26761 ctattattat gagtttgttg gaaacagcta aacgtcatca attaaatagc gagaaatatc
    26821 tattctatct tctagaatgt cttccaaacg aggaaactct cgtaaacaaa gaggttttag
    26881 aggcttattt accatggact aaagttgtac aagaaaaatg caaataagaa atctccagat
    26941 taggaactat ccgtgagttc tctagtctgg agatttttcg gctctttgtc aactgtagtg
    27001 ggttgaaaaa aagctaagct cgagaaagga caaattttgt cctttctttt tttagaaata
    27061 gtattaaaaa ttccttgact atgtgatata gttgagggat ttttaaatga tattcatatt
    27121 ttttgcaaag atgttgtttg aaaaataatt ttcaaaaatt ctgaaaattc tgttgacaac
    27181 tttctgaaaa gagtctataa tggagagaaa gttttaaagg agaaaatgat gaaaagttca
    27241 aaactatttg cccttgcggg cgtgacatta ttggcggcga ctactttagc tgcatgctct
    27301 ggatcaggtt caagttcaag cactaaaggt gagaagacat tctcatacat ttatgagaca
    27361 gaccctgata acctcaacta tttgacaact gctaaggctg cgacagcaaa tattaccagt
    27421 aacgtggttg atggtttgct agaaaatgat cgctacggga actttgtgcc gtctatggct
    27481 gaggattggt ctgtatccaa ggatggattg acttacactt atactatccg taaggatgca
    27541 aaatggtata cttctgaagg tgaagaatac gcggcagtca aagctcaaga c
//
