LOCUS       CR931639               17506 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain 2616/39 (serotype 6b).
ACCESSION   CR931639
VERSION     CR931639.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 17506)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 17506)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..17506
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="2616/39"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC06B_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC06B_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI32831.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            293..458
                     /gene="aliB"
                     /locus_tag="SPC06B_0002"
                     /pseudo
     CDS             293..458
                     /gene="aliB"
                     /locus_tag="SPC06B_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(459..984)
                     /gene="tnp"
                     /locus_tag="SPC06B_0003"
                     /pseudo
     CDS             complement(join(459..779,781..984))
                     /gene="tnp"
                     /locus_tag="SPC06B_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1207..2652
                     /gene="wzg"
                     /locus_tag="SPC06B_0004"
     CDS             1207..2652
                     /gene="wzg"
                     /locus_tag="SPC06B_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI32834.1"
                     /db_xref="GOA:Q4K2Y7"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K2Y7"
                     /translation="MSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNEHIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSTLHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAIIKKLTST
                     EVLKNYSSILQGLQDSLQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1207..1323
                     /gene="wzg"
                     /locus_tag="SPC06B_0004"
                     /note="Signal peptide predicted for SPC0146 by SignalP 2.0
                     HMM (Signal peptide probability 0.993) with cleavage site
                     probability 0.538 between residues 39 and 40"
     misc_feature    1411..1758
                     /gene="wzg"
                     /locus_tag="SPC06B_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 1.2e-62"
     misc_feature    1936..2379
                     /gene="wzg"
                     /locus_tag="SPC06B_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 6.5e-70"
     gene            2654..3385
                     /gene="wzh"
                     /locus_tag="SPC06B_0005"
     CDS             2654..3385
                     /gene="wzh"
                     /locus_tag="SPC06B_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI32835.1"
                     /db_xref="GOA:Q4K2Y6"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4K2Y6"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAEAYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLGKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVYVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     misc_feature    2657..3265
                     /gene="wzh"
                     /locus_tag="SPC06B_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 3.6e-38"
     gene            3391..4086
                     /gene="wzd"
                     /locus_tag="SPC06B_0006"
     CDS             3391..4086
                     /gene="wzd"
                     /locus_tag="SPC06B_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI32836.1"
                     /db_xref="GOA:Q9AHB8"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q9AHB8"
                     /translation="MMKEQNTIEIDVFQLFKTLWQRKLMILLVALVTSAGAFAYSTFI
                     VKPEYTSTTRIYVVNRNQGDKPGLTNQDLQAGTYLVKDYREIILSQDALEKVATNLKL
                     DMPAKTLASKVQVAVPADTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDV
                     TTLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDIEDVLKI
                     PLLGLVPDFDKMK"
     misc_feature    3412..3828
                     /gene="wzd"
                     /locus_tag="SPC06B_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 1.1e-53"
     misc_feature    3934..4011
                     /gene="wzd"
                     /locus_tag="SPC06B_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4096..4785
                     /gene="wze"
                     /locus_tag="SPC06B_0007"
     CDS             4096..4785
                     /gene="wze"
                     /locus_tag="SPC06B_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI32837.1"
                     /db_xref="GOA:Q9AHB7"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q9AHB7"
                     /translation="MPTLEISQAKLDSVKKAEEYYNALCTNLQLSGDGLKVFSITSVK
                     IGEGKSTTSTNIAWAFARAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNIENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEAGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            4800..6167
                     /gene="wchA"
                     /locus_tag="SPC06B_0008"
     CDS             4800..6167
                     /gene="wchA"
                     /locus_tag="SPC06B_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32838.1"
                     /db_xref="GOA:Q4K2Y3"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4K2Y3"
                     /translation="MNGKIVKSSLAIIQSFLVILLTYLLSAVRETEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESNEVVGEL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIVGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYINGWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    4800..4886
                     /gene="wchA"
                     /locus_tag="SPC06B_0008"
                     /note="Signal peptide predicted for SPC0150 by SignalP 2.0
                     HMM (Signal peptide probability 0.759) with cleavage site
                     probability 0.388 between residues 29 and 30"
     misc_feature    5583..6164
                     /gene="wchA"
                     /locus_tag="SPC06B_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 1.7e-160"
     gene            6263..7207
                     /gene="wciN"
                     /locus_tag="SPC06B_0009"
     CDS             6263..7207
                     /gene="wciN"
                     /locus_tag="SPC06B_0009"
                     /note="member of homology group 62"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32839.1"
                     /db_xref="GOA:Q9AHB5"
                     /db_xref="InterPro:IPR002495"
                     /db_xref="UniProtKB/TrEMBL:Q9AHB5"
                     /translation="MNIVYATDNNFVDVLSASIKSLYTTNSDLDLNLWIIADKVSDRN
                     KEKINRLSKQFAQREINWIENVEIPFKLHLDRGSISSFSRLFLGSVLPSSMSKVLYLD
                     SDIIVMDSLRSIFDIDFKGKILYGVNDTFNKEYKQVLGIPIDKPMFNAGVMLINLELW
                     RNNNVEERFLQVIQKFNGTILQGDLGVLNAVLYNSFGVLPPEYNYMTIFEDLTYEEMI
                     VFKKPINYYSKEEIKNARERIVLRHFTTSFLSKRPWQEGSNVAHIDQFKKYYEGSYKN
                     VKESILLKIVQKLPKKCSVFLLGIIQSKFRPKLYRILK"
     misc_feature    6266..7036
                     /gene="wciN"
                     /locus_tag="SPC06B_0009"
                     /note="HMMPfam hit to PF01501, Glycosyl transferase
                     family, score 3.9e-72"
     gene            order(7209..7388,7390..7491)
                     /gene="HG263"
                     /locus_tag="SPC06B_0010"
                     /pseudo
     CDS             join(7209..7388,7390..7491)
                     /gene="HG263"
                     /locus_tag="SPC06B_0010"
                     /note="member of homology group 263"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative LicD-family phosphotransferase
                     (pseudogene)"
                     /db_xref="PSEUDO:CAI32840.1"
     gene            7478..8197
                     /gene="wciO"
                     /locus_tag="SPC06B_0011"
     CDS             7478..8197
                     /gene="wciO"
                     /locus_tag="SPC06B_0011"
                     /note="member of homology group 81"
                     /codon_start=1
                     /transl_table=11
                     /product="putative ribitol phophotransferase"
                     /protein_id="CAI32841.1"
                     /db_xref="GOA:Q4K2Y1"
                     /db_xref="InterPro:IPR000462"
                     /db_xref="UniProtKB/TrEMBL:Q4K2Y1"
                     /translation="MSIYRICKDIERKTMSPAKKAMAKNDYFAFYVGRPLSYLLTVPF
                     VKTNITPNQISYLSIIPLIVGFIIMIFTTDFVVLLLAWFLFFLWNLLDGVDGNLARYR
                     EQYSKDGSVVDAMAGYVAMVLTYFGAGIVAAHLNDSDIYIILGALSGISLIFPRLVMH
                     KYINTVAQDESVSSIKDKSDFNTIKILALNMTSITGIPQVLLLLTILTNQWVLFTLVY
                     FTINFLLMIFSLYSLFKKENV"
     misc_feature    7721..8185
                     /gene="wciO"
                     /locus_tag="SPC06B_0011"
                     /note="HMMPfam hit to PF01066, CDP-alcohol
                     phosphatidyltransferase, score 0.01"
     gene            8200..9186
                     /gene="wciP"
                     /locus_tag="SPC06B_0012"
     CDS             8200..9186
                     /gene="wciP"
                     /locus_tag="SPC06B_0012"
                     /note="member of homology group 97"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32842.1"
                     /db_xref="GOA:Q9AHB3"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q9AHB3"
                     /translation="MGKSVAILMTTYNGERYLSQQIDSIRSQTFTNWTLFIRDDGSKD
                     KTIEVIQRYSKIDDRIRFVENPSKFHGAYYNFFNLIEYVKNNYQFDYYFFCDQDDIWK
                     EHKLEIQLLRFSKDDMPEMVYSDMSTIDASNNLIDISINKIMGIELPNINNLYFIHAY
                     IWGCTAGFNHALLEMVPSVDIDKDYLYIEKLSHDNYFAKFALEYGKVLFCPEQLVLYR
                     RHGHNVTTSHHFKLSPLNVFRKAILGFNELALTHAGVYNQTLYMLKKASGKNPLSDRL
                     LEIQEVIKIGGLKGVRYFYQNRISRKQLVRTIGLYTIMLFGTYKKYIMKELL"
     misc_feature    8215..8718
                     /gene="wciP"
                     /locus_tag="SPC06B_0012"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 4.9e-25"
     gene            9186..10529
                     /gene="wzy"
                     /locus_tag="SPC06B_0013"
     CDS             9186..10529
                     /gene="wzy"
                     /locus_tag="SPC06B_0013"
                     /note="member of homology group 139"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI32843.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K2X9"
                     /translation="MLLNFLFISIFLLIIITFILFEGDFFQPAVILTIAYFISIASAL
                     VNRNVWGTELHFKTFYLILLGVATFVIVSLLTKLSYRPKVEGISHEELKEINPSKIIY
                     VILLTLNLVMLFLYIREIQKVVLFSGRSFSNITDLISNYRYLSYYSNEVENRVSGMIN
                     QLSKIIPATTLISLYIFMNNYFITKQIKKNFIYLIPIAIFFVYAIISGGRLPLIRLVV
                     GALLILYIYSVYGSPKSQLTKSFKMITRSLFTFLILIVLFFLLKFVLGRSSQEDFISY
                     ITRYMGGSIQLFDLFVIDPIRRNKELGAETFSGIYEMLAKLGFDNNIIKGLEWRVSPN
                     YYSLGNVYTAIRRYYSDFGVIGIVICQSFTAWLYTLGYEKVRHYSLVTNVQRFRLILL
                     AASFYPIFLNGIEDVFYISMVTIGYGIQIVIFYLVFWVLLKVQVDFNKGKLTINR"
     misc_feature    9186..9314
                     /gene="wzy"
                     /locus_tag="SPC06B_0013"
                     /note="Signal peptide predicted for SPC0155 by SignalP 2.0
                     HMM (Signal peptide probability 0.938) with cleavage site
                     probability 0.688 between residues 43 and 44"
     gene            10654..12066
                     /gene="wzx"
                     /locus_tag="SPC06B_0014"
     CDS             10654..12066
                     /gene="wzx"
                     /locus_tag="SPC06B_0014"
                     /note="member of homology group 82"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI32844.1"
                     /db_xref="UniProtKB/TrEMBL:Q9AHB1"
                     /translation="MKLKFLITNLFHVFLSNLITIVTSVIVVLILPKIMGVTEYSYWQ
                     LYIFYLTYIGFFHLGWIDGIYLKYGGLEYQNLDKKQFYSQILQFFSFLILISFLLFGF
                     NLLIVTDPNAKYIYNMTIISMIVTNLRMLFVYILQMTNRLKDSSIILISDRVIYIFLL
                     FLFIIFKWHEYKVMIWADVLGRTFSLLLSFWICKDIVFQSLSEFILDLRESFDNIRVG
                     INLMLSNIASSMIIGIVRMGIQWNWNIETFGKVSLTLSISNLLMTFINAIGLVVFPLL
                     KRTKTENLSKIYSNLRNVLMLIMFAILLFYYPLKIILDLWLPAYRDALIFMALIFPMS
                     IYEGKMALVINTYLKALRMERDILKINTLIMLFSMLVTLITTLLLNNLELTVISIVVL
                     LALRSIIAELILSKKLDISVEQDIVLELLMTIIFISSSWYLPIWLAVIVYLLAYTLYL
                     YLKRKDTKMYIEYFRKKIFE"
     misc_feature    10654..10761
                     /gene="wzx"
                     /locus_tag="SPC06B_0014"
                     /note="Signal peptide predicted for SPC0156 by SignalP 2.0
                     HMM (Signal peptide probability 0.692) with cleavage site
                     probability 0.398 between residues 36 and 37"
     gene            12534..13403
                     /gene="rmlA"
                     /locus_tag="SPC06B_0015"
     CDS             12534..13403
                     /gene="rmlA"
                     /locus_tag="SPC06B_0015"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI32845.1"
                     /db_xref="GOA:Q8RSF0"
                     /db_xref="HSSP:1FXO"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q8RSF0"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSV
                     ALILGDNIYHGPGLSKMLQKAAKKEKGATVFGYQVKDPERFGVVEFDTDMNAISIEEK
                     PEYPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    12537..13253
                     /gene="rmlA"
                     /locus_tag="SPC06B_0015"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.3e-120"
     gene            13404..14000
                     /gene="rmlC"
                     /locus_tag="SPC06B_0016"
     CDS             13404..14000
                     /gene="rmlC"
                     /locus_tag="SPC06B_0016"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI32846.1"
                     /db_xref="GOA:Q4K2X6"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4K2X6"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKNHSLLKDVKPLKKEDLE"
     misc_feature    13440..13970
                     /gene="rmlC"
                     /locus_tag="SPC06B_0016"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 1.1e-15"
     gene            14010..15059
                     /gene="rmlB"
                     /locus_tag="SPC06B_0017"
     CDS             14010..15059
                     /gene="rmlB"
                     /locus_tag="SPC06B_0017"
                     /EC_number="4.2.1.46"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI32847.1"
                     /db_xref="GOA:O54546"
                     /db_xref="HSSP:1KEP"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:O54546"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    14025..14981
                     /gene="rmlB"
                     /locus_tag="SPC06B_0017"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00012"
     misc_feature    14028..14768
                     /gene="rmlB"
                     /locus_tag="SPC06B_0017"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 5.4e-77"
     misc_feature    14031..14843
                     /gene="rmlB"
                     /locus_tag="SPC06B_0017"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 1.4e-05"
     gene            15125..15976
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
     CDS             15125..15976
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI32848.1"
                     /db_xref="GOA:Q9AH81"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AH81"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAKMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    15125..15973
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 4.3e-146"
     misc_feature    15128..15757
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 2e-18"
     misc_feature    15128..15769
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00011"
     misc_feature    15131..15859
                     /gene="rmlD"
                     /locus_tag="SPC06B_0018"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 3.6e-08"
     gene            16039..17141
                     /gene="glf"
                     /locus_tag="SPC06B_0019"
     CDS             join(16039..16638,16638..17141)
                     /gene="glf"
                     /locus_tag="SPC06B_0019"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
                     /protein_id="CAI32849.1"
                     /db_xref="GOA:Q4K083"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K083"
                     /translation="MYDYLIVGAGLFGAVFAHESALKGKKVKVIEKRNHIAGNIYTRE
                     EEGIQVHQYGAHIFHTSDKEIWDYVNQFAEFNRYTNSPVANYKGEIYNLPFNMNTFNK
                     LWGVVTPAEAQAKIEEQRAILNGKTPENLKEQAISLVGTDIYEKLIKDYTEKQWGKPT
                     TELPSFIIRRLPVHLTYDNNYFNDTYQGIPIGGYTQIVEKMLDYENIDVETNVDFFVN
                     KEQYLKDFPKIVFTGMIDEFFDYKLGELEYRSLRFENETLDMENYQGNAVVNYTDAET
                     PYTRIIEHKHFEFGSQAKTIITKEHSKTWEKGDEPYYPVNNDRNNHLYKSYKKFADEQ
                     GNVIFGGRLGHYRYYDMHQVIGAALQCVRNELD"
     misc_feature    join(16474..16638,16638..17081)
                     /gene="glf"
                     /locus_tag="SPC06B_0019"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 1.9e-107"
     gene            17459..>17506
                     /gene="aliA"
                     /locus_tag="SPC06B_0020"
     CDS             17459..>17506
                     /gene="aliA"
                     /locus_tag="SPC06B_0020"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI32850.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ89"
                     /translation="MMKSSKLLALAGVTLL"
BASE COUNT     5705 a   2618 c   3511 g   5672 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaggactgt ataaaagaca gaaatccttt gttttttata accaaagttt ataaactttc
      241 attcttgaaa ttcaattaac tttacaaatt cccactatta aggagaaaga agatgaacat
      301 aaagaagcgt gtccttagtg caggcctgac ttttgcatct gctttgcttt tagctgcttg
      361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac
      421 atttaactat ctattagact attacactga taatatagtc aattgaaaca agaacaagac
      481 aaaagagcct cataaaaggt attgcaactt ggtaatacct ttttgaggtg ctttttgata
      541 tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt
      601 ttatgcctaa actcttcgca taaaagttct aacttaccca ttctatggaa tcttgcatta
      661 tccataataa taaccgatgg tgtggttaat gttggtaaga gaaacttctg aaaccatact
      721 tcaaaaaagt cgctcgtcat catctcttcg taagtcattg gagcgattaa ctcaccattc
      781 atttgttaga cctgcaacca aagaaatcct ccgatatctt cttccagata ttttgcctct
      841 tcttaactga ccttttaaag agcgaccata ttctcgataa aaataagtat cgaatcctgt
      901 ttcatcaatc taaacaggtg ctaggtgctt taaactatta aaattcttaa gaaataaggc
      961 tactttttct gggtcttgtt cataattaga ttgaaactag aatagtacac ctctgcttct
     1021 aaaacattgt tagaaatcga tttgactgtc ctgatcgttt tgtcatgttc ttatttcatt
     1081 ttactatatt tttggttcgt gggaagtcta ctaagatact taaagatgca gatagtgaaa
     1141 aaaggtgtag acattaccgt aaaaaagtga tataatcgta tgatgttcaa tgtataggtg
     1201 ttaatcatga gtagacgttt taaaaaatca ggttcacaga aagtgaagcg aagtgttaat
     1261 atagttttgt tgactattta tttattgtta gtttgttttt tattgttctt aatctttaag
     1321 tacaatatcc ttgcttttag atatcttaat ctagtggtaa ctgcgttagt cctactagtt
     1381 gccttggtag ggctactctt gattatctat aaaaaagctg aaaaatttac tatttttcta
     1441 ttggtgtttt ctatccttgt cagctcagtg tcgctctttg cagtacagca gtttgttgga
     1501 ctgaccaatc gtttaaatgc gacttctaat tactcagaat attcaatcag tgtcgctgtt
     1561 ttagcagata gtgatatcga aaatgttacg caactgacga gtgtgacagc accgactggg
     1621 actgataatg aacatattca aaaactacta gctgatatca agtcaagtca gaataccgat
     1681 ttgacggtca accagagttc gtcttacttg gcagcttaca agagtttgat tgcaggggag
     1741 actaaggcca ttgtcctaaa tagtgtcttt gaaaatatca tcgagtcaga gtatccagac
     1801 tacgcatcga agataaaaaa gatttatacc aagggattca ctaaaaaagt agaagctcct
     1861 aagacgtcta agaatcagtc tttcaatatc tatgttagtg gaattgacac ctatggccct
     1921 attagttcgg tgtcgcgatc agatgtcaat atcctgatga ctgtcaatcg agataccaag
     1981 aaaatcctct tgaccacaac gccacgtgat gcctatgtac caatcgcaga tggtggaaat
     2041 aatcaaaaag ataaattaac ccatgcgggc atttatggag ttgattcgtc cattcacacc
     2101 ttagaaaatc tctatggagt ggatatcaat tactatgtgc gattgaactt cacttctttc
     2161 ttgaaaatga ttgacttatt gggaggggta gatgttcata atgatcaaga attttcaact
     2221 ctacatggga agttccattt cccagtaggg aatgtccatc tagactctga gcaggctcta
     2281 ggttttgtac gtgaacgcta ctcactagcc gatggagacc gtgaccgtgg tcgcaaccaa
     2341 caaaaggtca ttgtagcaat tattaagaag ttaacttcta cagaggtttt gaaaaactat
     2401 agtagtattc ttcaaggatt gcaggattct cttcaaacaa atatgccgat tgagactatg
     2461 atagatttag tgaatactca gttggagagt ggagggaatt ataaagtaaa ttcgcaagac
     2521 ttgaaaggta caggtcggat ggatcttcct tcttatgcaa tgccagacag taacctctat
     2581 gtgatggaaa tagatgatag tagtttagct gtagttaaag cagctataca ggatgtgatg
     2641 gagggtagat gaaatgatag acatccattc gcatatcgtt tttgatgtag atgacggtcc
     2701 caagtcaaga gaggaaagca aggctctctt ggcagaagcc tacagacagg gggtgcgaac
     2761 cattgtctct acctctcacc gtcgcaaggg catgtttgaa actccggaag agaagatagc
     2821 agaaaacttt cttcaggttc gggaaatagc taaggaagtg gcgagtgact tagtcattgc
     2881 ttacggggct gaaatttact acacaccaga tgttctggat aagctgggaa aaaagcggat
     2941 tccgaccctc aatgatagtc gttatgcctt gatagagttt agtatgaata ctccttatcg
     3001 cgatattcat agcgccttga gcaagatttt gatgttggga attactccag tcattgccca
     3061 cattgagcgc tatgatgctc ttgaaaataa tgaaaaacgc gttcgagaac taatcgatat
     3121 gggctgttac acgcaagtaa atagttcaca tgtcctcaaa cccaaacttt ttggcgaacg
     3181 ttataaattc atgaaaaaaa gagctcagta ttttttagag caggatttgg tttatgtcat
     3241 tgcaagtgat atgcacaatc tagacggtag acctcctcat atggcagaag catatgacct
     3301 tgttacccaa aaatacggag aagcgaaggc tcaggaactt tttatagaca atcctcgaaa
     3361 aattgtaatg gatcaactaa tttaggagaa atgatgaaag aacaaaacac gatagaaatc
     3421 gatgtatttc aattatttaa aaccttgtgg caacgcaagc taatgatttt attagtggca
     3481 cttgtgacaa gtgcgggggc ttttgcatat agcactttta ttgttaagcc agaatatacg
     3541 agtaccacgc gaatttacgt agtgaatcgc aatcaaggag acaagccggg gctgacaaat
     3601 caggatttgc aggcaggaac ttatctggta aaagactacc gtgagattat cctttcgcag
     3661 gatgcattgg aaaaagtagc gacaaatttg aagttggata tgccagcaaa aacgttagcc
     3721 agcaaagttc aagtggctgt accagctgac actcgtatcg tctcaatctc tgtcaaggat
     3781 aaacagccag aggaagccag tcgtatcgct aattctctac gagaagttgc tgcagaaaag
     3841 atcgtcgctg taacgcgagt atctgatgta acgacacttg aagaagcgcg accagctacg
     3901 actccctctt ctccaaatgt tcgacgcaat tccttgtttg gttttcttgg aggagcagtc
     3961 gtaacagtaa ttgctgttct tttgattgag ttgctcgaca cccgtgtgaa acgtcctgaa
     4021 gatattgaag atgtactgaa aattccactt ttagggctcg ttccagattt tgacaaaatg
     4081 aaataggagg aagttatgcc aacattagaa atctcacagg caaaattgga ttctgtaaaa
     4141 aaggcagagg aatattataa cgctttgtgc acgaacctac agttaagtgg agatggtttg
     4201 aaagtatttt ctatcacttc tgtgaaaata ggagaaggaa aatcaacgac ttccaccaat
     4261 atcgcttggg cttttgcgcg tgcaggttac aaaacgctgc tgattgatgg agatattcgc
     4321 aattctgtta tgttaggtgt ctttaaagca agggataaga ttacaggcct gacagaattt
     4381 ttatcaggaa ctacagacct atcacaaggg ctttgtgata ccaatatcga aaatctcttt
     4441 gtaattcagg ctggctctgt gtcaccgaat ccgacagctc ttcttcaaag taagaatttc
     4501 agtacaatgc ttgaaacctt gcgtaaatat tttgactaca tcattgtaga tactgctcct
     4561 gtcggtgtcg tgattgatgc ggctattatt acgcgaaaat gcgatgcttc tattttagtg
     4621 acggaggcag gtgaaataaa tcgacgggat attcaaaaag caaaagaaca gttggaacac
     4681 acagggaagc cgtttttggg agttgtgttg aataaattcg atacttcagt agacaaatac
     4741 ggttcttatg gaaattatgg agattacggg aaaaataaaa aataggtcgg gggatagaga
     4801 tgaatggaaa aatagtaaag tcttcattgg ccataatcca gagctttctt gttattttat
     4861 tgacttatct acttagtgct gtgagagaaa cggagattgt ttcaacaaca gctattgcac
     4921 tttatatcct ccattatttt gtcttttata tcagtgatta tggacaggat ttctttaaaa
     4981 ggggatattt gattgaactt gtccagacat tgaaatatat cctattcttt gcactagcga
     5041 ttagtatttc taattttttc ttagaggatc gatttagtat ttccagacga ggcatgattt
     5101 acttcctcac attacatgct ctcttagtct atgtgctaaa cctatttatc aagtggtatt
     5161 ggaagcgggc ttatcccaac tttaaaggaa gtaagaagat tctcctactt acagcaactt
     5221 ctcgtgtcga aaaggtactg gatagattaa tagaatcaaa tgaggttgtt ggggagttgg
     5281 tagccgtcag tgtcttagat aaaccagatt ttcagcatga ttgtttaaag gtagtagcag
     5341 agggggagat agtaaacttt gcgactcatg aggtggtcga tgaagtcttt atcaatcttc
     5401 caagtgaaaa atacaatatt ggagagcttg tctctcagtt tgaaacgatg ggaattgatg
     5461 taacagtcaa tctaaatgct tttgatcgta gtttggcacg taacaagcaa attcgtgaga
     5521 tggcaggatt aaacgttgtg actttttcta caacatttta taagactagt catgtaattg
     5581 ctaagcggat tattgatatc gtgggtgcat tggtagggct gatactatgt ggtttagtca
     5641 gtattgtact ggttcctttg attcgaaagg atgggggctc tgctattttt gctcagacgc
     5701 gtataggaaa aaatggtcgt cagttcactt tttataagtt tcgctctatg tgtgtagatg
     5761 ccgaggcgaa aaaaagagaa ctcatggaac aaaataccat gcagggtgga atgtttaagg
     5821 tggacgatga tcctcgtatc acgaaaattg gtcgttttat acggaagact agcttggacg
     5881 agctaccaca gttttacaat gttctaaagg gagatatgag cttggtaggt acacgaccac
     5941 caacagtgga cgagtatgag cactataccc cagaacaaaa acgccgacta agttttaaac
     6001 ctggcataac aggtttatgg caggtcagcg gacgaagtga aatcaagaat ttcgatgaag
     6061 ttgtcaaatt agatgtggcc tatattaatg gttggacaat ctggaaagat attgaaattt
     6121 tattgaaaac ggttaaagtt gtatttatga gagatggagc gaaatagttt ggttgtgtag
     6181 gatatttgta gaggtaaaag tttcgaatat atctcactca atctttttta taagtgaaaa
     6241 taaatttaga agtaggaatt ttatgaatat agtttatgcc acagataata attttgtaga
     6301 tgtattgagt gcttccatca aatcacttta cactactaat tcagatttgg atttaaattt
     6361 atggattatt gctgataaag tttcggatag aaataaagaa aagataaata gattatcaaa
     6421 acaatttgcg cagagagaaa ttaattggat agagaacgtt gagatcccat ttaaattaca
     6481 tttagatagg ggatcaatta gttcatttag cagattattt ctgggaagtg ttcttccatc
     6541 ttcaatgagt aaagttcttt atcttgacag tgatattatt gttatggatt ctttacgaag
     6601 tatttttgat attgatttta agggtaaaat tctctatggg gtgaatgata cttttaataa
     6661 agaatacaag caggtgttgg gtataccaat tgacaagcca atgtttaatg ctggagttat
     6721 gcttattaat ttagagttat ggagaaataa taacgtcgaa gaaagatttt tgcaagtaat
     6781 tcaaaagttt aatggtacta tattacaagg agatttaggg gttttaaatg cagttttata
     6841 taactcattt ggtgtacttc ctccagaata taattatatg accatatttg aagatttgac
     6901 ttatgaagaa atgatagttt ttaaaaaacc aattaattat tattcaaaag aggaaattaa
     6961 aaatgccaga gaacgtatag tcttacgaca tttcacaact agttttttat caaaaagacc
     7021 ttggcaagaa ggcagtaatg ttgcacatat agaccaattt aaaaaatact atgaaggtag
     7081 ttataaaaat gttaaagaat ctattttact aaaaatagtt caaaaattac ccaaaaaatg
     7141 ttcagttttt ttattaggaa ttattcaatc aaaatttaga cctaaattgt atagaatttt
     7201 gaaataaggt ggatagtatt aatgacaaaa aagaaagaat tttattgaaa attcaagaag
     7261 aattgaaatt attaaaagag tttataaaaa tatgttctaa aaataaaatt aagtattttg
     7321 ctcttggagg tagtctatta ggagctgtaa gacacaaagg tttcattcct tgggatgata
     7381 tggatctaag ctttccaaag agttcaatct atgtttgaaa taaaggaaaa agtgttagaa
     7441 ttagagaatg tattaatgag tttaggagaa agtatagatg tcaatatata gaatctgtaa
     7501 agatattgaa agaaaaacta tgtcgcctgc taaaaaagca atggctaaaa acgactattt
     7561 tgcattttat gttggaagac ctttatccta tcttttaaca gttcctttcg tgaaaacaaa
     7621 tattactccc aatcaaatat cttatttatc tataattcct ttgattgttg gatttataat
     7681 aatgatattt acaactgatt tcgttgtatt attactggca tggtttctat tttttttatg
     7741 gaacttacta gatggagtag atgggaactt agccagatat cgggagcaat actcgaagga
     7801 tggaagtgta gtagatgcaa tggctggcta tgtagccatg gtgttgacgt atttcggtgc
     7861 aggaatagta gctgctcatt taaacgactc agatatctat ataattttgg gtgcattatc
     7921 tgggatttca ttgatttttc caaggttagt gatgcataag tatatcaata cagtagctca
     7981 agatgagtct gtgagtagca ttaaagataa atctgatttt aatactataa aaatactggc
     8041 tctaaacatg acatcaatta caggaattcc gcaggtttta ctgctattaa ctattttaac
     8101 aaatcagtgg gtacttttta ctttagtata ttttacgatt aattttttat taatgatatt
     8161 ttctttgtat tcattattca aaaaggagaa tgtttagaaa tgggaaagtc agttgcaatt
     8221 ttaatgacca cctataatgg tgagcgatat ttgtcacaac agattgatag tattaggtct
     8281 caaacattca ctaattggac actttttatt agggatgatg gatcaaaaga taaaacaata
     8341 gaagtaatac agaggtattc taagatagat gatagaatta gattcgttga aaatccctca
     8401 aagtttcatg gagcttatta caattttttt aatctaattg aatacgttaa aaacaattat
     8461 caatttgatt attacttttt ttgtgatcaa gatgatattt ggaaagagca caagttagaa
     8521 atacagctgt taagattttc taaagatgac atgccagaga tggtttactc tgatatgtca
     8581 acgattgatg ccagtaataa tttgatagat attagtataa ataaaataat ggggattgaa
     8641 ttaccgaaca taaataattt gtattttatt catgcctata tctgggggtg tactgcaggt
     8701 tttaatcatg cattgctaga gatggttcct tcagttgata ttgataaaga ttatttatat
     8761 atagaaaaac tgtctcatga taattatttt gcaaagtttg cactagagta tgggaaggtg
     8821 ttgttctgcc ctgagcaact ggtcttgtat cgaagacatg gacataatgt aacaactagt
     8881 catcatttta aattatctcc gctaaatgtt ttcagaaagg ctatattggg tttcaatgaa
     8941 ttggcactta cacatgctgg ggtatataat caaactcttt atatgctaaa aaaagcttct
     9001 ggaaaaaatc ctttaagtga tagactactt gaaattcagg aagtaatcaa aattggagga
     9061 ttaaaaggtg tgagatattt ctatcagaat cgaatttctc gaaagcaact cgtaagaaca
     9121 atcggcttat ataccatcat gctttttggg acctataaaa aatatattat gaaagaactc
     9181 ttataatgct tttaaatttc ttattcatat ctatttttct attaattatc attacattta
     9241 tattatttga gggggatttt tttcaacctg cagtaatttt aacaatcgct tattttattt
     9301 cgattgcaag tgctctagtt aatagaaatg tttggggaac agaactccat ttcaaaacct
     9361 tttatttgat attgttaggg gttgctacat ttgttatagt ttccttgttg acaaaattgt
     9421 cgtacaggcc taaagtggag ggaatttcgc atgaagaatt gaaagaaata aatccttcaa
     9481 agataatcta tgtcattctt ctgactctaa atcttgttat gctatttctt tatatccgtg
     9541 aaattcagaa agtagtattg ttttcaggta gaagtttttc taatattaca gatttgataa
     9601 gtaactatag gtacctatct tattattcaa atgaagtaga aaatcgtgta agtggaatga
     9661 ttaatcaact atctaaaatt attccagcga ctacacttat ttctttatat atatttatga
     9721 ataattattt tataactaaa caaataaaga aaaatttcat ttatttgatt ccaatagcta
     9781 tattctttgt ctatgcaatc attagtggtg gtagattgcc ccttataagg ttagttgttg
     9841 gagctctgtt gatattgtat atatactctg tgtacgggag tcctaaatct caacttacca
     9901 aaagttttaa aatgatcact cgctctctgt ttacatttct tattttgata gttttattct
     9961 ttcttttaaa atttgtatta gggcgctcct ctcaggaaga ttttatcagt tacatcactc
    10021 gttatatggg aggttcaatt caactatttg atttatttgt tatagatccg atacgacgta
    10081 acaaagaact aggtgcagaa actttttcgg gaatttatga gatgcttgca aaattaggat
    10141 ttgacaataa tattataaaa ggcttagaat ggagagtgtc tcctaattat tattctttag
    10201 ggaatgtgta tactgcaatt agacgttatt attcagactt tggtgtaatt ggtattgtaa
    10261 tttgtcagag ttttacagcg tggttatata ctttaggtta tgaaaaagtt agacattatt
    10321 ctttagttac aaatgttcaa agatttaggt tgatcctatt agcagcttca ttttatccaa
    10381 tatttttaaa tggtatcgag gatgtgtttt atatttcaat ggttaccatt ggatatggaa
    10441 tacaaattgt tatcttttat ctggtctttt gggttcttct gaaagttcag gttgacttta
    10501 acaaaggtaa attaacgata aatagatgaa tttagcgcta atgtattgag tcatataaag
    10561 ggatatattt ggtaggtatt ttaattggag gaagagagcc ttgaaaggga agtacaaatc
    10621 ttctgaaata atttttaggt ggggagtata gctatgaaat tgaagtttct tataacaaat
    10681 ttgtttcatg tctttttgtc taatctgatt acaattgtca catcggttat agttgtacta
    10741 attttaccaa aaattatggg agtaactgag tatagttatt ggcaactata tattttttac
    10801 ctaacatata ttggtttttt tcatctgggt tggattgatg gaatttatct taaatatggt
    10861 ggattagagt accagaattt agataagaaa cagttttatt ctcaaatact tcaatttttc
    10921 agttttttaa ttttaatttc ttttctatta tttggtttta acttattgat tgtgacagat
    10981 ccaaatgcaa aatatattta taacatgact attattagta tgatagttac aaatttaaga
    11041 atgttattcg tttatatttt gcagatgaca aatcgattaa aggatagctc tataattctg
    11101 ataagtgatc gcgttatata tatttttctt ttatttctgt ttattatatt taaatggcat
    11161 gaatacaagg taatgatttg ggcggatgtt ttaggaagga cattttctct cctactttct
    11221 ttttggattt gtaaagatat tgtttttcaa tccttatccg agttcatatt ggatctgaga
    11281 gagtcttttg acaatatccg tgttggaatc aatttaatgt tatccaatat tgcaagtagt
    11341 atgattattg gtattgttcg aatgggaatt caatggaatt ggaatatcga aacattcggg
    11401 aaagtatcac tgacgctaag catctctaat ttattaatga cttttattaa tgcgattggt
    11461 ttagttgtct ttcctttgtt aaaacggaca aaaacggaaa atttatctaa aatttattcc
    11521 aacttaagaa atgttttgat gctgatcatg tttgcaatat tgctctttta ttatccttta
    11581 aaaattattc tagatctttg gttgccagct tatcgggatg cgttgatttt tatggctctt
    11641 atttttccta tgtcaattta tgaagggaag atggccttgg tgattaatac atatttaaag
    11701 gcgctaagga tggaaagaga tattctcaaa ataaatactt tgattatgtt gttcagtatg
    11761 ttagttaccc taataactac tctattatta aataatttag agctaacggt tatatctata
    11821 gttgttttgc tagctttacg tagtataata gcagaactaa ttctatctaa aaaacttgat
    11881 atatcagttg agcaagacat tgtgttagaa ttacttatga caattatatt tatttcttca
    11941 agttggtact taccgatttg gctcgcagta atagtttatt tgttagcgta tactttatac
    12001 ttgtatctaa agcgtaaaga tacaaaaatg tatatagaat attttagaaa gaaaatattt
    12061 gaataaaaag aactatatat cagttagatg gcaaattcta tttttacctt tttgtcgttt
    12121 aatagaaaat gataaaaaat atgatattat tcttacacat atttataagt aatttaaaat
    12181 aagaatagtt tctggaacat tgctattagt gggaacaggt tacgaaataa tttatcaatt
    12241 ttaaagatgt ttttttaaat ataaaataat ggattctgtc aacaattcta aattctaata
    12301 ggaatgataa tgctagaaaa tcagattgtt catttttcaa ggaagtttat ttttaaaata
    12361 atatatcttt aagtaagaat tattttatta gacttaacct agcctatcag ttaaattaga
    12421 atatcaactt tgattaatta aaaattagca aaatttattg acattttgtt tttataaatt
    12481 gcaataaagg tctaattctg aatttcagtg aatataagaa agggatccta ctaatgaaag
    12541 gtattattct tgcaggtggt tcggggacac gattatatcc tttgactcgg gctgcatcaa
    12601 aacaacttat gccggtttat gataaaccga tgatttacta tccactttca acattgatgt
    12661 tggctgggat tagggatatt ttgataatct caactcctca agatttgcct cgttttaaag
    12721 agcttcttca agacggatct gagtttggga ttaaactttc ttatgcagag caaccaagtc
    12781 cagatggttt ggcacaagcc tttatcattg gggaagagtt tattggtgat gatagtgttg
    12841 ctttgatttt gggggacaat atctatcacg gccctggttt gagcaaaatg cttcaaaaag
    12901 cagccaagaa agagaaaggt gcgactgttt ttggctacca agtgaaggat ccagagcgtt
    12961 ttggtgtggt tgagtttgat acagacatga atgctatctc catcgaagaa aagccagaat
    13021 accctcgttc aaactatgca gtgacaggac tctatttcta tgataatgat gtagtagaga
    13081 ttgccaagag tatcaaacca agtcctcgcg gagaattaga aatcacagat gtcaacaagg
    13141 cttacttgga tcgtggagac ttatccgttg agcttatggg acgtggcttt gcttggctgg
    13201 atactggaac tcatgaaagt ttactagagg cttcacagta catcgaaaca gtgcaacgga
    13261 tgcaaaatgt tcaggtagca aacttagaag aaattgctta ccgtatgggc tatatcagtc
    13321 gagaagatgt attggcctta gcccaaccac ttaagaaaaa tgaatacgga cagtatctgc
    13381 tccgtttgat tggagaagca tagatgacag ataatttttt cggtaagacg cttgcggcac
    13441 gcaaggttga agctattcca ggcatgttgg agtttgatat ccccgttcat ggagataatc
    13501 gtggctggtt taaagaaaat ttccaaaagg aaaaaatgct tccacttgga tttccagagt
    13561 ctttctttgc agaaggaaaa ttgcaaaaca atgtatcctt ctcacgtaaa aatgtccttc
    13621 gaggcctcca cgcagagcct tgggataagt acatctctgt agcagatgga gggaaagttc
    13681 tgggttcttg ggttgatcta cgcgagggtg aaacctttgg gaatacctat cagacagtga
    13741 ttgatgcgag taagggaatc tttgttcctc gaggcgtagc taatggcttc caagttttat
    13801 cagatacagt gtcatatagc tatctggtca atgattactg ggctcttgaa ctcaaaccca
    13861 agtatgcctt tgtgaactac gctgatccaa gccttggtat tgaatgggaa aatattgcag
    13921 aagcagaggt ttcagaagca gataaaaatc attcactact taaggatgta aaacctttga
    13981 aaaaagaaga tttggaataa ggaaagaata tgactgaata caaaaatatt atcgtgacag
    14041 gtggagctgg ctttatcggt tctaactttg tccattatgt ttacgagaac tttccagatg
    14101 ttcacgtgac agtcctagat aagttgactt atgctggaaa ccgcgcgaat attgaggaaa
    14161 ttttaggtaa tcgtgttgag ttagttgttg gtgacattgc tgatgcggag ttggtagaca
    14221 agttggctgc tcaagcagat gctatcgttc attatgcagc ggaaagccac aatgataatt
    14281 cgctcaatga tccatcgcca tttattcata ctaacttcat tggaacctat actcttttag
    14341 aagctgctcg taagtatgat attcgcttcc accatgtatc gacagatgaa gtttatggag
    14401 atctcccttt acgcgaagat ttgccaggtc atggagaagg gccgggtgag aaatttacgg
    14461 ctgaaaccaa gtacaatcca agctcgcctt actcatcaac caaggcagcc tcagatttga
    14521 ttgtcaaagc ctgggtgcgt tcttttggag tcaaggcaac gatttccaac tgttcaaata
    14581 actacggtcc ttatcaacat atcgaaaaat tcatcccacg tcagattact aacatcctaa
    14641 gtggtatcaa gccaaaactt tacggtgaag gtaaaaacgt tcgtgactgg attcatacca
    14701 atgaccattc ttcaggagtt tggacaatct tgacaaaagg gcaaatcggt gaaacctact
    14761 tgattggggc tgatggtgag aagaacaata aggaagtttt ggaacttatc cttaaggaaa
    14821 tgggacaagc tgcggatgcc tatgatcatg tgactgaccg tgcaggacat gaccttcgct
    14881 atgcgattga tgctagcaag ctccgtgatg agttggggtg gaaacctgaa tttaccaact
    14941 ttgaagctgg gctcaaggca acaatcaagt ggtatacaga taaccaagaa tggtggaaag
    15001 cagaaaaaga agctgttgaa gccaattatg ctaagactca ggagattatt acagtataaa
    15061 aagcaggaaa tagctgcttt ttattgctat attgggaaga gttacatatt agaaaggtct
    15121 agagatgatt ttaattacag gggcaaatgg ccaattagga acggaacttc gctatttatt
    15181 ggatgaacgt aatgaagaat acgtggcagt agatgtggct aagatggaca ttaccaatga
    15241 agaaatggtt gagaaagttt ttgaagaggt gaaaccgact ttagtctacc attgtgcagc
    15301 ctacaccgct gttgatgcag cagaggatga aggaaaagag ttggacttcg ccatcaatgt
    15361 gacggggaca aaaaatgtcg caaaagcatc tgaaaagcat ggtgcaactc tagtttatat
    15421 ttctacggac tatgtctttg acggtaagaa accagttgga caagagtggg aagttgatga
    15481 ccgaccagat ccacagacag aatatggacg cactaagcgt atgggggaag agttagttga
    15541 gaagcatgtg tctaatttct atattatccg tactgcctgg gtatttggaa attatggcaa
    15601 aaacttcgtt tttaccatgc aaaatcttgc gaaaactcat aagactttaa cagttgtaaa
    15661 tgatcagtac ggtcgtccga cttggactcg taccttggct gagttcatga cctacctagc
    15721 tgaaaatcgt aaggaatttg gttattatca tttgtcaaat gatgcgacag aagacacaac
    15781 atggtatgat tttgcagttg aaattttgaa agatacagat gtcgaagtca agccagtaga
    15841 ttccagtcaa tttccagcca aagctaaacg tccgctaaac tcaacgatga gcctggccaa
    15901 agccaaagct actggatttg ttattccaac ttggcaagat gcattgcaag aattttacaa
    15961 acaagaagtg agataagtag tagaatgatt ttctagtcta ataaaagagg cagagaatga
    16021 actccaaagg agcataagat gtacgattat cttatcgttg gtgccggtct ttttggtgca
    16081 gtatttgccc atgaatcagc cttaaaagga aaaaaagtaa aagttattga aaaacgaaat
    16141 catattgcgg gtaatatcta tactcgtgaa gaggaaggaa ttcaagttca tcagtatggt
    16201 gctcatatct ttcatacttc tgataaggag atctgggatt atgtgaacca gtttgcagag
    16261 tttaaccgtt atacaaattc tcctgttgca aactataagg gagagattta taacttacct
    16321 tttaatatga ataccttcaa taaactctgg ggagttgtga cgccagcaga agcacaagct
    16381 aagattgagg aacaacgtgc tattttaaat ggtaaaactc ctgaaaattt gaaagaacag
    16441 gcgatttctc ttgtaggtac agacatctac gaaaaattaa tcaaagacta tacagagaaa
    16501 cagtggggca aaccaactac tgaacttcca tcctttatta ttcgccgttt accagtacac
    16561 ctgacctatg ataacaacta ttttaacgat acctatcaag ggattccaat tggtggatac
    16621 actcaaatag ttgaaaaatg ttggattatg aaaatattga tgtagaaaca aatgttgatt
    16681 tctttgtgaa caaagagcaa tatctgaaag attttcctaa gattgtcttt actggtatga
    16741 ttgatgaatt ctttgactat aagttgggcg aactagagta ccgtagtctt cgttttgaaa
    16801 atgagacctt ggatatggaa aattaccaag gaaatgcagt tgtgaactat acggatgcag
    16861 aaaccccata tactcgcatt attgaacaca aacattttga gtttgggagt caagcaaaga
    16921 ctatcattac taaagaacat tctaaaacat gggaaaaagg tgatgagcct tattatccag
    16981 ttaataatga tcgtaataat catttgtata aatcgtataa aaaatttgct gatgagcaag
    17041 ggaatgttat ctttggtggc cgcttaggac actatcgtta ttacgatatg caccaagtaa
    17101 ttggagcagc tttgcagtgc gtgagaaatg agttagatta atactcaatg aaaatcaaag
    17161 agcaaactag gaagctagcc acaggttgct caaaatactg ttttgaggtt gcagatggaa
    17221 gctgacgcgg tttgaagaga ttttcgaaga gtataaacaa gtaaaactga ctaccagtta
    17281 ttatttagaa atagtattaa aaattccttg actatgtgat atagttgagg gatttttaaa
    17341 tgatattcat atttttttca aagatgttgt ttgaaaaata attttcaaaa attctgaaaa
    17401 ttctgttgac atctttctga aaagagtcta taatggagag aaagttttaa aggagaaaat
    17461 gatgaaaagt tcaaaactac ttgcccttgc gggcgtgaca ttattg
//
