LOCUS       CR931641               21441 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Streptococcus pneumoniae strain Johnson (serotype 7b).
ACCESSION   CR931641
VERSION     CR931641.1
KEYWORDS    .
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21441)
  AUTHORS   Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D.,
            Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L.,
            Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B.,
            Reeves,P.R., Parkhill,J. and Spratt,B.G.
  TITLE     Genetic analysis of the capsular biosynthetic locus from all 90
            pneumococcal serotypes
  JOURNAL   PLoS Genet. 2 (3), E31 (2006)
   PUBMED   16532061
REFERENCE   2  (bases 1 to 21441)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2004) Submitted on behalf of the Pathogen
            Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk
COMMENT     NOTE: This sequence was generated from a PCR product representing
            the region from dexB to aliA and is not necessarily responsible for
            the expressed capsule serotype. For a detailed description of how
            CDS products were predicted see the associated publication.
FEATURES             Location/Qualifiers
     source          1..21441
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="Johnson"
                     /db_xref="taxon:1313"
     gene            <1..134
                     /gene="dexB"
                     /locus_tag="SPC07B_0001"
     CDS             <1..134
                     /gene="dexB"
                     /locus_tag="SPC07B_0001"
                     /codon_start=3
                     /transl_table=11
                     /protein_id="CAI32876.1"
                     /db_xref="UniProtKB/TrEMBL:Q4JZI8"
                     /translation="SNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVPWDAFCVELL"
     gene            293..466
                     /gene="aliB"
                     /locus_tag="SPC07B_0002"
                     /pseudo
     CDS             293..466
                     /gene="aliB"
                     /locus_tag="SPC07B_0002"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative oligopeptide-binding protein AliB
                     (pseudogene)"
     gene            complement(order(459..980,985..1074))
                     /gene="tnp"
                     /locus_tag="SPC07B_0003"
                     /pseudo
     CDS             complement(join(459..980,985..1074))
                     /gene="tnp"
                     /locus_tag="SPC07B_0003"
                     /note="member of homology group 4"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="putative IS630-Spn1 transposase (fragment)"
     gene            1219..2664
                     /gene="wzg"
                     /locus_tag="SPC07B_0004"
     CDS             1219..2664
                     /gene="wzg"
                     /locus_tag="SPC07B_0004"
                     /note="member of homology group 0"
                     /codon_start=1
                     /transl_table=11
                     /product="integral membrane regulatory protein Wzg"
                     /protein_id="CAI32879.1"
                     /db_xref="GOA:Q4K2U9"
                     /db_xref="InterPro:IPR004190"
                     /db_xref="InterPro:IPR004474"
                     /db_xref="UniProtKB/TrEMBL:Q4K2U9"
                     /translation="MSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSLSVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKLSQNTDLT
                     VDQSSSYLVAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALSFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIIDSLQDSIQTNMPLETMIDLVNAQLESGGTYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR"
     misc_feature    1219..1335
                     /gene="wzg"
                     /locus_tag="SPC07B_0004"
                     /note="Signal peptide predicted for SPC0193 by SignalP 2.0
                     HMM (Signal peptide probability 0.993) with cleavage site
                     probability 0.538 between residues 39 and 40"
     misc_feature    1423..1770
                     /gene="wzg"
                     /locus_tag="SPC07B_0004"
                     /note="HMMPfam hit to PF02916, DNA polymerase processivity
                     factor, score 3.9e-61"
     misc_feature    1948..2391
                     /gene="wzg"
                     /locus_tag="SPC07B_0004"
                     /note="HMMPfam hit to PF03816, Cell envelope-related
                     transcriptional a, score 2e-69"
     gene            2666..3397
                     /gene="wzh"
                     /locus_tag="SPC07B_0005"
     CDS             2666..3397
                     /gene="wzh"
                     /locus_tag="SPC07B_0005"
                     /EC_number="3.1.3.48"
                     /note="member of homology group 1"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-tyrosine phosphatase Wzh"
                     /protein_id="CAI32880.1"
                     /db_xref="GOA:Q4JZ20"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR016667"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ20"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSCHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     misc_feature    2669..3277
                     /gene="wzh"
                     /locus_tag="SPC07B_0005"
                     /note="HMMPfam hit to PF02811, PHP domain, score 1.9e-38"
     gene            3406..4098
                     /gene="wzd"
                     /locus_tag="SPC07B_0006"
     CDS             3406..4098
                     /gene="wzd"
                     /locus_tag="SPC07B_0006"
                     /note="member of homology group 2"
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Wzd"
                     /protein_id="CAI32881.1"
                     /db_xref="GOA:Q4JZ19"
                     /db_xref="InterPro:IPR003856"
                     /db_xref="InterPro:IPR005701"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ19"
                     /translation="MQDQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSTTRIYVVNRNQEEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVISDLKLD
                     LTPKGLANKIKVIVPIDTRIVSVSVNDRVPEEASRIANSLREVAAKKIISITRVSDVT
                     TLEEARPAISPSSPNIKRNTLIGFLAGGLGTSVIVLLLELLDTRVKRPEDIEDTLQMT
                     LLGVVPNLSKLK"
     misc_feature    3424..3840
                     /gene="wzd"
                     /locus_tag="SPC07B_0006"
                     /note="HMMPfam hit to PF02706, Chain length determinant
                     protein, score 5.8e-51"
     misc_feature    3946..4023
                     /gene="wzd"
                     /locus_tag="SPC07B_0006"
                     /note="PS00217 Sugar transport proteins signature 2."
     gene            4108..4791
                     /gene="wze"
                     /locus_tag="SPC07B_0007"
     CDS             4108..4791
                     /gene="wze"
                     /locus_tag="SPC07B_0007"
                     /EC_number="2.7.10.1"
                     /note="member of homology group 3"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase Wze"
                     /protein_id="CAI32882.1"
                     /db_xref="GOA:Q4JZ18"
                     /db_xref="InterPro:IPR002586"
                     /db_xref="InterPro:IPR005702"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ18"
                     /translation="MPTLEIAQKKLEFIKKAEEHYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDAQKAKQQLEQTGKLFLGVVLNKLDISVDKYGVY
                     GSYGNYGKK"
     gene            4807..6174
                     /gene="wchA"
                     /locus_tag="SPC07B_0008"
     CDS             4807..6174
                     /gene="wchA"
                     /locus_tag="SPC07B_0008"
                     /note="member of homology group 5"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32883.1"
                     /db_xref="GOA:Q4JZ17"
                     /db_xref="InterPro:IPR003362"
                     /db_xref="InterPro:IPR017475"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ17"
                     /translation="MDEKGLKIFLAVLQSIIVILLVYFLSFVRETEVERSSMVILYLL
                     HFFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAIGVLNFFIVERFSISRRGMVYF
                     LTLEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKL
                     VAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFINLPGESYDIGEIISRFETMG
                     IDVTVNLNAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHLISKRILDICGATIGLIL
                     FAIASLVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTM
                     QGGMFKINNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPK
                     QKRRLSFKPGITGLWQVSGRSKITDFDAVVKLDVAYIDNWTIWKDIEILLKTVKVVFM
                     RDGAK"
     misc_feature    5590..6171
                     /gene="wchA"
                     /locus_tag="SPC07B_0008"
                     /note="HMMPfam hit to PF02397, Bacterial sugar
                     transferase, score 2.3e-145"
     gene            6205..7386
                     /gene="wchF"
                     /locus_tag="SPC07B_0009"
     CDS             6205..7386
                     /gene="wchF"
                     /locus_tag="SPC07B_0009"
                     /note="member of homology group 15"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32884.1"
                     /db_xref="GOA:Q4JZ16"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="InterPro:IPR015393"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ16"
                     /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMR
                     ENSAKSGTTEDVFEHNGAICYNVDVPNIGPARAIAYDIAAINRAIEIAKENKDENPIF
                     YILACRIGPFIHGIKKRIQAIGGTLLVNPDGHEWLREKWSLPVRKYWKYSERLMVKYA
                     DLLVCDSKNIEQYIQEDYKQFQPKTTYIAYGTDTTPSILKFEDTKVRNWYQEKGISEN
                     GYYLVVGRFVPENNYEAMIREFIKSQSKKDFVLITNVEQNKFYDKLLRETGFDQDPRI
                     KFVGTVYDQELLKYIRENAFAYLHGHEVGGTNPSLLEALGSTKLNLLLDVGFNREVGE
                     DGAIYWQKDELSRVIEYVETINQATIANLNFKSTQRILSDFTWEKIVADYEGVFCFAK
                     S"
     misc_feature    6820..7314
                     /gene="wchF"
                     /locus_tag="SPC07B_0009"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 0.0035"
     gene            7388..8233
                     /gene="wcwI"
                     /locus_tag="SPC07B_0010"
     CDS             7388..8233
                     /gene="wcwI"
                     /locus_tag="SPC07B_0010"
                     /note="member of homology group 99"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32885.1"
                     /db_xref="GOA:Q4K2U3"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K2U3"
                     /translation="MPNLYAVVVLYNSLLSEAKILKTLNTLNCKELNLIVVDNSDRKE
                     IQLKNKNFSTENNITLVNMNGNQGLSKAYNKVLELLKGRIGYVVWLDDDTEISVEYLT
                     KLLYASRGNYDIILPIIQDTHGKIVSPNSRGLLSNKPIKSYKDGKKLEKFNAINSCTA
                     VNLDIYEEYRYDERLFLDEIDHSFFYDHRNKNLKIELINTIVIQNFSQRADNLNFDTA
                     WSRLKIRIRDLIVAYKIRGGIFMGLVAVLKSILLGLQLYLKIKDLRIVIYSFTSALCI
                     FFRKT"
     misc_feature    7400..7897
                     /gene="wcwI"
                     /locus_tag="SPC07B_0010"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 4.9e-11"
     gene            8230..9426
                     /gene="wcwL"
                     /locus_tag="SPC07B_0011"
     CDS             8230..9426
                     /gene="wcwL"
                     /locus_tag="SPC07B_0011"
                     /note="member of homology group 100"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32886.1"
                     /db_xref="GOA:Q4K2U2"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q4K2U2"
                     /translation="MKMKILYFMNNTDHGGAALALLDLVTQINENYPEYELIVVTGKK
                     NNLNVKLTEIGIENYFFPFRNFISSYKKPAILWTILYKIRHYIGNRMALKKIEKKIDL
                     KKIDIIHSNLNRIDIGAILAKKHSIPHLWHIREHLDVWYFYNKLDHRKFEYGLKVLTT
                     EKNYIFYMCSFSTKYIAISNSVAMDWCKKGLSQSSIVKVYDGIKLPQVFGDKKWFRNK
                     KINIVFVGGYDIKKGQELFLSYFLKLPKEIQMQYTLTFYGSGKSKYIKKLQKMSQHLC
                     SDQVKFHSYIDNLTELLPNYDIGINFSTTEGFGRVIVEYLANGLCVVASKNGASPELI
                     TEEVGFLIDKDNQDEFIQLFTKLSIEKNKIRQMGNKAIEHAQKFSIDQHTREIINVYQ
                     EMRNKQ"
     misc_feature    8845..9351
                     /gene="wcwL"
                     /locus_tag="SPC07B_0011"
                     /note="HMMPfam hit to PF00534, Glycosyl transferases
                     group, score 3.8e-22"
     gene            9423..10430
                     /gene="wcwK"
                     /locus_tag="SPC07B_0012"
     CDS             9423..10430
                     /gene="wcwK"
                     /locus_tag="SPC07B_0012"
                     /note="member of homology group 64"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32887.1"
                     /db_xref="GOA:Q4K2U1"
                     /db_xref="UniProtKB/Swiss-Prot:Q4K2U1"
                     /translation="MKNMEQIDFVVTWVNDKDVDWCKRKSEFEKEYNIFQDLNSEERY
                     REWGLMKYWFRAVEKYAPWVNKIYFITEGHVPNWLDVNHPKLVHVKHEDYIEKQFLPT
                     FNSNVIEMNLIHLKDLSEKFVLFNDDFFINDFVKQSDFFENNLPKDTGIFSPLIPREN
                     SLTPIILNNMEIINKYFSKKKILEQNFSKFFNIKYGKHLLKNICLLPWSDLLGFYDNH
                     IPVSYCKSNFLEVYEKEHAIFNLTFKNKFRNKNEINHWLIRYWQLSSGNFIPRNINFG
                     KNYAISNDPTDIINELKLSKYKIICINDGESIDNFDAVKGLMINAFEKKFPEKSSFEK
                     K"
     gene            10427..11353
                     /gene="wcxU"
                     /locus_tag="SPC07B_0013"
     CDS             10427..11353
                     /gene="wcxU"
                     /locus_tag="SPC07B_0013"
                     /note="member of homology group 101"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="CAI32888.1"
                     /db_xref="GOA:Q4K2U0"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="UniProtKB/TrEMBL:Q4K2U0"
                     /translation="MRQIRMNLEDLVLIILNYNSAKDTLRCLEILRSFNMNFKIIVVD
                     NNSTDNSIELLKNIEDPQTTFLISDENRGYGAGNNIGIHFAENHFSSNIIGIINPDIV
                     IPNQEVIISMYNVLKNSDFAMVGGSVIDNEGNYRLLNSSWDLPSFKSVVLERFLIYNR
                     HKVPYCLNMYNDETAIVDCVAGCFFMIKADVMKEIGYFDENVFLYNEENILGMKLREK
                     GFQSIILTKQFYYHLHDFEKDKVELSLSKKCKRDWVKFQSRKYFTEKYYSKFLGFLLF
                     FVEIFNLFQIMIGHLKNNIIKKNLKGNSSEKK"
     misc_feature    10460..11014
                     /gene="wcxU"
                     /locus_tag="SPC07B_0013"
                     /note="HMMPfam hit to PF00535, Glycosyl transferase
                     family, score 6.6e-19"
     gene            11340..12587
                     /gene="wzy"
                     /locus_tag="SPC07B_0014"
     CDS             11340..12587
                     /gene="wzy"
                     /locus_tag="SPC07B_0014"
                     /note="member of homology group 65"
                     /codon_start=1
                     /transl_table=11
                     /product="polymerase"
                     /protein_id="CAI32889.1"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T9"
                     /translation="MKKSSTLHSSTLHIGLILFLIVLSKNFFNLVPNIALFSDFNLMI
                     IIIIMTVVNIKYYNRSTKYQYRWYIIFTLIFVLYSAINEKLLYGQPFLLGLLPQRQFF
                     LCLMTYFPLRKYFQEQNISLKKLYVGIMNLGSISSLIYILQKIVILYGGTQFVNVMYS
                     FAGYFSGYRLYVGSSLIILATLISTAYFLETLKLKYLCHLILGWFTEIWITQGRIEMI
                     VLLISTIVCIIVQGRLTRKKIIYWLLTILGLWMITLTPIFENIVGAILKVDGAGRGSD
                     SLTIRAIGRQLYWDQLNETTSKLLFGTGYPNYNYALAFQRTGFSSNIFLTDNGFMTYI
                     YIFGIVGSSIMGLLFLKYLKNSIKYARQSADMIPLMYIISLLIVAYNIILWYWNADGT
                     FILVIMICALEHGEQLLHQRNGV"
     gene            12592..14544
                     /gene="rbsF"
                     /locus_tag="SPC07B_0015"
     CDS             12592..14544
                     /gene="rbsF"
                     /locus_tag="SPC07B_0015"
                     /note="member of homology group 49"
                     /codon_start=1
                     /transl_table=11
                     /product="putative phosphotransferase"
                     /protein_id="CAI32890.1"
                     /db_xref="GOA:Q4K2T8"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006439"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T8"
                     /translation="MNLNKEVRWKDKQYIAFDFFDTTIHRNCHPEVILFEWSKKISIY
                     FSFKISATEIYSIRKKSEIHEKQEKQLEEIKYERLLQLVFYTILSRLKSDVTDYTLED
                     FLIYARTCEEEIELRHISIDTDTINFIEFLKQNGKKIILISDFYSDKKLIEKLMVSLG
                     IRDYFSKIFISSEIGLRKSSGNLYEYVINELSCKPINLLMIGDNIYSDVKVPKKLGID
                     SYHKSYSDSHVTVSPNDIVKAMNNVISQACTESLFNLYIPEILYFISKLYKELSVNKA
                     SDILFCAREGFFIKKLFDLYQKKMNLKLINSHYFYVSRKSTLYPSFKNIEDEDFEVIF
                     RQFPEITLENFLINLNFSNNDINNISKQTEIKQTDKVSDKSIINKLKQNKLFKDVYDL
                     NCKEEKYSFREYLKSVGVENDNSTINMVDIGWKGTIQDNIQKAFPSLNIKGYYMGLNF
                     QRYSTRNSMNKTGILFTDDPQKTKFFNLFNYKYLFYERIFVADHGPTVRYEFMNGVGV
                     PTLDTDENHIEIYRFSEEFQITFFNTFEKILDLFNESLVTPDELFNEIANLSLKKHCI
                     YLPRLSVSIKKLDRAAKENFGIIKSTNRNSDNKVRNFWKNRDFLFLDYIYKAYGKNRL
                     LNPILDIYGYFVYLIKTLQIKIVGDI"
     misc_feature    12625..13266
                     /gene="rbsF"
                     /locus_tag="SPC07B_0015"
                     /note="HMMPfam hit to PF00702, haloacid dehalogenase-like
                     hydrolase, score 2e-07"
     gene            14550..16001
                     /gene="wzx"
                     /locus_tag="SPC07B_0016"
     CDS             14550..16001
                     /gene="wzx"
                     /locus_tag="SPC07B_0016"
                     /note="member of homology group 47"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="CAI32891.1"
                     /db_xref="GOA:Q4K2T7"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T7"
                     /translation="MKEKSINKNAILNIILTLTNIVFPLITFPYISRILNPSGIGAIS
                     FFSSIGSYGVLVASLGISTYGIRVIAKDRYHKDKITKIFQELIVINSVMSIIVTFFLV
                     LMSFRLEQLSSEKGLLIITCITILSSPFNLNWFYSGIEEYSYITKRSIFFKLVSLILT
                     FLFVKSKDDYILYAVITLFSTLASNFINILESRKYINFNLRRDLEFRYHLKPMWYLFA
                     SLLAVNIYINLDSVMLGIINGNDAVGIYSIASKVKWILLSVVTSVSSVLLPRLSFYSN
                     KYDETKFNNILRKSSTIIFMISIPLTIFFMIKAKESILLLGGEQYIQAVLAMQILMPI
                     LVISGFSNITGNQILIPTGNEKYFMRAVSIGAIVNLCLNLLLMPILGIIGGAIATLCA
                     ESVQMIIQFYFSRNKLMGNISLNSIKKIAYSSIFAGILLIVIQNIIENFNSFLNLAAS
                     SFLYFGVYFFLLVLFKESTIKKFLNQIFYKDIS"
     misc_feature    14565..15374
                     /gene="wzx"
                     /locus_tag="SPC07B_0016"
                     /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
                     protein, score 1.3e-61"
     gene            16176..17045
                     /gene="rmlA"
                     /locus_tag="SPC07B_0017"
     CDS             16176..17045
                     /gene="rmlA"
                     /locus_tag="SPC07B_0017"
                     /EC_number="2.7.7.24"
                     /note="member of homology group 10"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RmlA"
                     /protein_id="CAI32892.1"
                     /db_xref="GOA:Q4K2T6"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T6"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLHRFQELLQDGSEFGLKLSYAEQPSPDGLAQAFIIGEEFISDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEHPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     misc_feature    16179..16895
                     /gene="rmlA"
                     /locus_tag="SPC07B_0017"
                     /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
                     score 3.2e-120"
     gene            17046..17642
                     /gene="rmlC"
                     /locus_tag="SPC07B_0018"
     CDS             17046..17642
                     /gene="rmlC"
                     /locus_tag="SPC07B_0018"
                     /EC_number="5.1.3.13"
                     /note="member of homology group 11"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase
                     RmlC"
                     /protein_id="CAI32893.1"
                     /db_xref="GOA:Q4JZ07"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q4JZ07"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPASFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDLE"
     misc_feature    17082..17612
                     /gene="rmlC"
                     /locus_tag="SPC07B_0018"
                     /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
                     3,5-epimerase, score 8.1e-16"
     gene            17652..18701
                     /gene="rmlB"
                     /locus_tag="SPC07B_0019"
     CDS             17652..18701
                     /gene="rmlB"
                     /locus_tag="SPC07B_0019"
                     /note="member of homology group 8"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-D-glucose 4,6-dehydratase RmlB"
                     /protein_id="CAI32894.1"
                     /db_xref="GOA:Q4K2T4"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T4"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGSRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     misc_feature    17667..18623
                     /gene="rmlB"
                     /locus_tag="SPC07B_0019"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 0.00012"
     misc_feature    17670..18410
                     /gene="rmlB"
                     /locus_tag="SPC07B_0019"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase fam, score 7.8e-77"
     misc_feature    17673..18485
                     /gene="rmlB"
                     /locus_tag="SPC07B_0019"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/iso, score 7.3e-06"
     gene            18767..19618
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
     CDS             18767..19618
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
                     /EC_number="1.1.1.133"
                     /note="member of homology group 9"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-keto-L-rhamnose reductase RmlD"
                     /protein_id="CAI32895.1"
                     /db_xref="GOA:Q9AH81"
                     /db_xref="HSSP:1N2S"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/TrEMBL:Q9AH81"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAKMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     misc_feature    18767..19615
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
                     /note="HMMPfam hit to PF04321, RmlD substrate binding
                     domain, score 4.3e-146"
     misc_feature    18770..19399
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
                     /note="HMMPfam hit to PF01370, NAD dependent
                     epimerase/dehydratase f, score 2e-18"
     misc_feature    18770..19411
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
                     /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
                     protein, score 0.00011"
     misc_feature    18773..19501
                     /gene="rmlD"
                     /locus_tag="SPC07B_0020"
                     /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
                     dehydrogenase/i, score 3.6e-08"
     gene            19681..20764
                     /gene="glf"
                     /locus_tag="SPC07B_0021"
                     /pseudo
     CDS             join(19681..20172,20172..20261,20261..20764)
                     /gene="glf"
                     /locus_tag="SPC07B_0021"
                     /EC_number="5.4.99.9"
                     /note="member of homology group 6"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase Glf"
     misc_feature    join(20098..20172,20172..20261,20261..20701)
                     /gene="glf"
                     /locus_tag="SPC07B_0021"
                     /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
                     score 7.9e-111"
                     /pseudo
     gene            21082..>21441
                     /gene="aliA"
                     /locus_tag="SPC07B_0022"
     CDS             21082..>21441
                     /gene="aliA"
                     /locus_tag="SPC07B_0022"
                     /codon_start=1
                     /transl_table=11
                     /protein_id="CAI32897.1"
                     /db_xref="GOA:Q4K2T2"
                     /db_xref="InterPro:IPR000914"
                     /db_xref="UniProtKB/TrEMBL:Q4K2T2"
                     /translation="MMKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETD
                     PDNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKD
                     AKWYTSEGEEYAAVKAQD"
     misc_feature    21082..21168
                     /gene="aliA"
                     /locus_tag="SPC07B_0022"
                     /note="Signal peptide predicted for SPC0211 by SignalP 2.0
                     HMM (Signal peptide probability 1.000) with cleavage site
                     probability 0.277 between residues 29 and 30"
     misc_feature    21328..21396
                     /gene="aliA"
                     /locus_tag="SPC07B_0022"
                     /note="PS01040 Bacterial extracellular solute-binding
                     proteins, family 5 signature."
BASE COUNT     7339 a   2952 c   4110 g   7040 t
ORIGIN
        1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa
       61 acaccctagc tcaagaagtc tttgaaaaac aaatcttagt tccatgggat gctttctgtg
      121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag
      181 ggaggactgt ataaaaggca gaaatccttt gttttttata accaaggttt ataaaccttc
      241 attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaaga agacgaacat
      301 aaagaagcgt atccttagtg caggcctgac ttttacatct gctttgcttt tagctgcttg
      361 cgaccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac
      421 atttaactat ctattagact attacgctga taatatagtc aattgaaaca agaacaagac
      481 aaaagagcct cataaaaggt attgcaactt ggtaatacct ttttgaggtg ctttttgata
      541 tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt
      601 ttatgcccaa actcttcgca taaaagttct agcttcccca ttctatggaa tcttgcatta
      661 tccataataa taaccgatgg tgtggttaat gttggtaaga aaaacttctg aaaccatact
      721 tcaaaaaagt cgctcgtcat catctcttcg taagtcattg gagcgattaa ttcaccattt
      781 gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt
      841 aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttca
      901 tcaatctaaa caggtgctag gtgctttaaa ctattaaaat tcttaagaaa taaggctact
      961 tttctgggtc ttgttcataa ttagattgaa actagagtag tagacctctg cttctaaaac
     1021 attgttagaa atcgatttga ctgtcctgat cgatttgtca tgttcttatt tcattttact
     1081 atatttttgt ttcgcgggaa gtctactaag atacttaaag atgcagatag taaaaaaaga
     1141 tgcagatagt aaaaaaatgt agacattacc gtaaaaaagt gatataatca taagatgttc
     1201 aatgtatagg tgttaatcat gagtagacgt tttaaaaaat caggttcaca gaaagtgaag
     1261 cgaagtgtta atatagtttt gctgactatt tatttattgt tagtttgttt tttattgttc
     1321 ttaatcttta agtacaatat ccttgctttt agatatctta atctagtggt aactgcgtta
     1381 gtcttactag tagccttggt agggctactc ttgattatct ataaaaaagc tgaaaaattt
     1441 actatttttc tgttggtgtt ctctatcctt gtcagctcag tgtcgctctt tgcagtacag
     1501 cagtttgttg gactgaccaa tcgtttaaat gcgacttcta attactcaga atattcgctc
     1561 agtgtcgctg ttttagcaga tagtgagatc gaaaatgtta cgcaactgac gagtgtgaca
     1621 gcaccgactg ggactgataa tgaaaatatt caaaaactac tagctgatat caagttaagt
     1681 cagaataccg atttgacagt cgaccagagt tcgtcttact tggttgctta caagagtttg
     1741 attgcagggg agactaaggc cattgtccta aatagtgtct ttgaaaatat catcgagtca
     1801 gagtatccag actacgcatc gaagataaag aagatttata ccaagggatt tactaaaaaa
     1861 gtagaagctc ctaagacgtc taagaatcag tctttcaata tctatgttag tggaattgac
     1921 acctatggtc ctattagttc ggtgtcgcga tcagatgtca atatcctgat gactgtcaat
     1981 cgtgatacca agaaaatcct cttgaccaca acgccacgtg atgcctatgt accaatcgca
     2041 gatggtggaa ataatcaaaa agataaatta acccatgcgg gcatttatgg agttgattcg
     2101 tccattcaca ccttagaaaa tctctatgga gtggatatca attactatgt gcgattgaac
     2161 ttcacttctt tcttgaaaat gattgactta ttgggagggg tagatgttca taatgatcaa
     2221 gagttttcag ctctacatgg gaagttccat ttcccagtag ggaatgtcca cctagactct
     2281 gagcaggctc taagttttgt acgtgaacgc tactcactag ccgatggaga ccgtgaccgt
     2341 ggtcgcaacc aacaaaaggt gattgtggct atccttcaaa aattaacgtc aaccgaagca
     2401 ctgaaaaatt atagtacgat cattgatagc ttgcaagatt ctatccaaac aaatatgcca
     2461 cttgagacca tgatagattt ggtcaatgct cagttagaaa gtggtggaac ttacaaagtg
     2521 aattcgcaag acttgaaagg tacaggtcgg atggatcttc cttcttatgc aatgccagac
     2581 agtaacctct atgtgatgga aatagatgat agtagtttag ctgtagttaa agcagctata
     2641 caggatgtga tggagggtag atgaaatgat agacatccat tcgcatatcg tttttgatgt
     2701 agatgacggt cccaagtcaa gagaggaaag caaggctctc ttggcagaat cctacaggca
     2761 gggggtgcga accattgtct ctacctctca ccgtcgcaag ggcatgtttg aaactccgga
     2821 agagaagata gcagaaaact ttcttcaggt tcgggaaatt gcaaaagaag tagcagatga
     2881 tttagtcatt gcttatggtg cagagatata ctatactctg gatgctctag aaaagctaga
     2941 aaaaaaagaa attcctaccc ttaatgatag tcgttatgcc ttgattgagt ttagcatgca
     3001 tacttcctat cgtcagattc atacgggatt gagcaatatt ttgatgttgg gaatcacacc
     3061 agtaattgct catattgaac gttatgatgc tttagagaat aacgaaaaac gtgttcgtga
     3121 actgattgat atggggtgct atactcagat aaatagttgt catgtttcaa aacctaagtt
     3181 ctttggtgaa aaatataaat tcatgaaaaa gagagctcgg tattttttgg aacgtgattt
     3241 agttcatgta gttgcaagtg acatgcacaa tttagacagt agacctccat atatgcaaca
     3301 ggcatatgat atcattgcta agaaatatgg agcgaaaaaa gcgaaagaac tttttgtaga
     3361 taatcccaga aaaattataa tggatcaatt aatttaggag aaaatatgca agatcaaaac
     3421 actttggaaa tcgatgtatt gcagctattc agagctttat ggaaaagaaa gttggtcatt
     3481 ttattagtgg caattataac ttcttcagtt gcttttgcct acagtacttt tgttatcaaa
     3541 cctgagttta ctagtacgac tcggatttat gtagttaacc gtaatcagga agagaagtct
     3601 ggtttaacca atcaagactt gcaggcagga acttatctgg taaaagacta ccgtgaaatt
     3661 atcctatcgc aggatgtttt ggaggaagtt atttctgatt tgaaactaga tttgacgcca
     3721 aaaggtttgg ctaataaaat taaagtaata gtaccaattg atacccgtat tgtctctgtt
     3781 tcagttaatg atcgagttcc tgaagaagca agccgtatcg ctaactcttt gagagaagta
     3841 gctgctaaaa aaattatcag tattactcgt gtttctgatg tgacaacact ggaggaggca
     3901 agaccggcga tatcaccgtc ttcgccaaat attaaacgca atacactaat tggttttttg
     3961 gcaggggggc ttggaactag tgttatagtt cttcttcttg aacttttgga cactcgtgtg
     4021 aaacgtccag aagatatcga agatacactg cagatgacac ttttgggagt tgtaccaaac
     4081 ttgagtaagt tgaaatagga gagaggaatg ccgacattag aaatagcaca aaaaaaactg
     4141 gagttcatta agaaggcaga agaacattac aatgccttgt gtacaaatat acagttgagc
     4201 ggagataaac taaaagtaat ttccgttact tctgttaacc ctggggaagg aaaaacaact
     4261 acttccgtaa atatagcaag gtcgtttgcg cgtgcaggct ataaaactct tttgatcgat
     4321 ggcgatactc gaaattcagt tatgtcagga ttttttaaat ctcgtgaaaa aattacaggg
     4381 ctaacagaat ttttatctgg gacagctgat ttatctcacg gtttatgtga tacaaatatt
     4441 gaaaatttat ttgtagttca atcgggatct gtatcaccaa accctacagc cttgttacag
     4501 agtaaaaatt ttaatgatat gattgaaaca ttgcgtaaat attttgatta tatcattgtt
     4561 gatacagcac ctattggaat tgttattgat gcggcaatta tcactcaaaa gtgtgatgcg
     4621 tccatcttgg taacagcaac cggtgaggtg aataaacgtg atgcccaaaa agctaaacaa
     4681 caattagaac aaacagggaa actgttccta ggagttgttt taaataaatt ggatatctcg
     4741 gttgataagt atggggtata cggttcctat ggaaattatg gtaaaaaata acttaggaaa
     4801 gattttatgg atgaaaaagg attgaaaatt tttctggcag tattacagag tattattgtc
     4861 attttattgg tttattttct tagctttgtt agagagacag aagttgaacg ttcttcgatg
     4921 gttatactat accttctcca cttttttgta ttctatttta gttcctatgg taacaatttt
     4981 tttaaaagag ggtacctagt tgagtttaat agtaccataa gatatatttt tttctttgca
     5041 atagctatag gtgtattaaa cttttttata gtggaacggt ttagtatctc tagaagagga
     5101 atggtatact tcttaacttt agaaggaata tccttatact tgttaaattt cttagtaaag
     5161 aaatattgga agcatgtgtt ttttaatcta aaaaatagca agaaaatttt actgttaaca
     5221 gtaacgaaaa atatggaaaa agttcttgat aaattgctag aatctgatga actttcatgg
     5281 aaattggtag cagtaagtgt tttggataaa tctgattttc aacatgataa aatacctgta
     5341 attgaaaagg aaaaaattat tgaatttgca acgcatgaag ttgtggatga ggtgtttatc
     5401 aatcttccag gagagagcta cgatattgga gaaattatct ctaggtttga gacaatgggg
     5461 atagatgtaa ctgtaaatct taatgcattt gataagaatt tgggtcgcaa taaacaaatt
     5521 catgagatgg taggattgaa tgtagtcact ttctctacaa atttttataa aactagtcat
     5581 ttgatttcaa agagaattct cgatatttgt ggtgccacta ttggccttat tctttttgct
     5641 atagctagtc tagttttagt tccattgatt cgtaaagatg gcggaccagc tatttttgct
     5701 caaactcgta tagggaaaaa tggtcgacat tttacctttt ataaattccg ttcaatgcgg
     5761 atcgatgctg aagctatcaa agaacagttg atggatcaaa atacgatgca aggtggtatg
     5821 tttaagataa acaatgatcc tcgtgttaca aaaattggtc gctttattcg taaaaccagt
     5881 ttggatgaat tgccacaatt ttggaatgtc tttattggag atatgagttt ggttgggacg
     5941 cgtccaccga cagtagacga atatgatcag tatactccaa aacagaaacg tcgactcagc
     6001 tttaagcctg gtattacagg cttatggcag gttagtgggc gtagtaaaat aaccgatttt
     6061 gatgctgttg taaaattaga tgtggcttat attgataatt ggacaatctg gaaagatatt
     6121 gaaattttgc ttaaaactgt taaagttgta tttatgagag atggagcgaa gtaatttctg
     6181 tatatccatc atattaggag agaaatgaaa aagtcagttt atatcattgg ttcaaaagga
     6241 attcctgcta agtatggagg atttgaaact tttgttgaaa aattaacagc cttccaacaa
     6301 gataaggcta tccaatatta tgtggcttgt atgcgtgaaa actctgcaaa atcagggact
     6361 actgaggatg tttttgaaca taatggtgct atctgttata acgtcgatgt tcctaatatt
     6421 ggtccagcgc gagctatagc gtatgatatc gctgcaatta acagagctat tgaaattgcc
     6481 aaagaaaata aggatgaaaa tccaatcttc tatattttag cttgtcgaat tggtccgttc
     6541 atccatggaa ttaagaaaag aattcaagca ataggtggga ctcttctggt taatccggat
     6601 ggtcatgagt ggctacgaga aaaatggagt ttacctgttc gcaaatattg gaaatactct
     6661 gaaagactta tggtcaaata tgcagattta ttggtttgtg acagtaaaaa tatcgaacag
     6721 tatatccaag aagattataa acagttccaa cctaagacca cctatatcgc ttatgggacc
     6781 gatacaactc cctcaatctt gaaatttgaa gatactaaag tccgaaattg gtatcaagag
     6841 aagggaatta gtgaaaacgg ttattattta gtggtgggac gatttgtccc tgagaataac
     6901 tatgaagcta tgattcgtga atttatcaaa tcccagtcta aaaaggattt tgtcctcatt
     6961 acaaatgtgg aacaaaataa attttacgac aagttgcttc gggaaacagg ttttgaccaa
     7021 gacccaagaa tcaaatttgt tggtactgtt tatgatcagg aattgttaaa atatattcga
     7081 gaaaatgcct ttgcatattt acatggtcat gaggtggggg ggacaaatcc atcactttta
     7141 gaggctttag gatcaacaaa gttaaatttg ttgcttgatg ttggttttaa ccgtgaagtt
     7201 ggtgaggatg gagctattta ttggcaaaaa gatgaacttt cacgagtcat cgaatatgtg
     7261 gaaacgataa atcaagcaac tatcgcaaac ttaaatttta aatcaaccca aagaatcctc
     7321 tcagatttta catgggaaaa aattgtggca gattatgaag gagtattttg ttttgcgaag
     7381 agttagtgtg cccaatttat atgcagtagt agttttatac aatagtttat tatcagaagc
     7441 aaaaatttta aaaaccttaa atacattaaa ttgtaaagaa ttaaacttaa ttgtagtaga
     7501 caatagtgat aggaaagaaa tacagttaaa aaataagaac ttttccactg aaaataatat
     7561 aacattggtg aatatgaatg gaaatcaggg attatctaaa gcttataata aagtcctaga
     7621 attattaaag ggtagaatag gttatgtggt ttggttagat gatgatactg agattagtgt
     7681 agaatattta acaaaattat tgtatgcatc aagaggtaat tacgacatta ttttgcctat
     7741 tattcaagat acccatggta aaattgtttc tccaaattct cgtggtttac tttcaaataa
     7801 accgattaaa agttacaaag atggaaaaaa acttgaaaaa tttaacgcaa taaatagttg
     7861 tacagctgtc aatttagaca tttatgaaga atatagatat gatgaacgac ttttcttgga
     7921 tgaaattgat cattcgtttt tctatgacca cagaaataaa aatttaaaga tcgaattaat
     7981 taatacaata gttattcaaa atttttctca aagggctgat aatttaaatt ttgatactgc
     8041 atggagtaga ttgaaaatta gaattcggga tttgatagtg gcttataaaa ttagaggtgg
     8101 gatttttatg ggtcttgtag ctgttttaaa aagtatccta cttggactcc agttatactt
     8161 gaaaattaag gatttgcgta tagttatcta tagtttcaca tctgctttat gtattttttt
     8221 tagaaagact tgaaaatgaa gattttatat tttatgaata atacagatca tggtggggct
     8281 gctttagcat tattagattt agttactcag ataaatgaga attatcctga gtatgaactt
     8341 attgttgtaa cagggaaaaa aaataattta aatgttaagt taacagaaat tggtattgaa
     8401 aattactttt ttccatttag aaattttatt agttcatata aaaaacctgc aatactatgg
     8461 acgattttat ataaaattcg tcattatatc ggaaatcgaa tggctctaaa aaaaatagaa
     8521 aaaaaaattg atttgaaaaa aatcgatatt attcattcta atttaaatag aatcgatata
     8581 ggagcaatat tagccaaaaa gcacagtata ccccatttat ggcatataag agagcatttg
     8641 gatgtatggt atttttataa taaattagat catagaaagt ttgagtatgg cttgaaggtc
     8701 ttgactacgg aaaaaaatta tattttttat atgtgttctt tttcaacgaa atatattgca
     8761 atctctaact ctgtagctat ggattggtgt aaaaaaggac tatctcagtc atctattgtt
     8821 aaagtttacg acggtatcaa gttacctcaa gtatttggtg ataaaaaatg gtttagaaat
     8881 aaaaaaataa atattgtatt tgttggtggt tacgatatta aaaaaggtca ggagttgttt
     8941 ttaagctatt ttttaaaatt accaaaagaa atacaaatgc aatatacttt gactttctat
     9001 ggaagtggga aatctaagta tataaagaaa ttacaaaaga tgtctcagca tctatgttct
     9061 gatcaagtta aatttcatag ttatatagat aatcttacag aattactacc aaattatgat
     9121 attgggatta atttttcaac aacggaaggt tttggaagag tgattgttga atatttagcg
     9181 aacggtcttt gtgttgttgc aagtaaaaat ggagctagtc cagaattaat aacagaagaa
     9241 gttggatttt taatcgacaa ggataatcag gatgaattta ttcagttgtt tactaaatta
     9301 tctattgaaa agaataagat aagacaaatg gggaataaag caattgaaca tgcacaaaag
     9361 ttttcaatag accaacatac aagagagatt ataaatgtat atcaagaaat gagaaataaa
     9421 cagtgaaaaa tatggaacaa attgattttg tggtgacatg ggttaatgat aaagatgtag
     9481 attggtgtaa aagaaagtct gaatttgaga aagaatataa tatatttcaa gatttaaata
     9541 gtgaagagcg ataccgtgaa tggggtctta tgaaatattg gtttagagct gtggaaaaat
     9601 atgccccttg ggtaaataaa atttatttta taaccgaagg gcatgtacca aattggttag
     9661 atgtaaatca tcctaaattg gttcatgtta aacatgagga ttatatcgaa aaacagtttt
     9721 tgccaacttt taattcaaac gttatagaga tgaatttgat tcatttgaaa gatttatcag
     9781 agaaatttgt tctttttaat gatgattttt tcataaatga ttttgtaaaa caaagtgatt
     9841 tttttgaaaa taatttaccc aaagatacgg ggatttttag tcctttaata ccaagagaaa
     9901 attctttaac tcctattata ttaaacaata tggagattat taacaaatat ttttcaaaga
     9961 aaaaaattct tgagcagaat ttttctaagt tttttaacat caaatatgga aaacatctat
    10021 tgaagaatat ttgtttactg ccatggtcag atttgttagg cttctatgat aatcatattc
    10081 cagtaagtta ttgtaaaagt aatttcttgg aagtttatga gaaagaacat gccattttta
    10141 atttgacgtt taaaaataaa tttaggaata aaaatgagat taatcattgg ttaattagat
    10201 attggcaatt gtctagcggt aatttcatac ctagaaacat taattttggg aaaaattatg
    10261 ccatttcaaa tgatcctacg gatattatta atgaattaaa actttctaaa tataagatta
    10321 tatgtattaa tgatggtgaa agtatagata attttgatgc agtgaaaggt ctaatgatta
    10381 atgcttttga aaaaaagttt cctgagaaat cgagttttga gaaaaagtga ggcagataag
    10441 aatgaatttg gaagatttag tattaataat tttaaattat aatagtgcta aagatacact
    10501 acgttgttta gaaattctac gttcttttaa tatgaatttt aaaattattg tagtggataa
    10561 taattctacg gacaattcaa tagaactact caagaatata gaggatcctc aaactacttt
    10621 tttaatttct gatgagaata gaggatatgg agcaggtaat aatattggga ttcactttgc
    10681 agaaaatcat ttttcttcaa atatcatagg tattattaat ccagatatag tcattcccaa
    10741 tcaggaagtg ataatttcaa tgtataatgt tttgaaaaat agtgactttg ctatggttgg
    10801 tgggtcagta atcgataatg agggaaatta tagactatta aattcatcat gggatttacc
    10861 ttcttttaag agcgttgtac ttgaaagatt tttaatatat aatcgacata aagttccata
    10921 ttgtttaaat atgtataatg atgaaacagc gattgtagat tgtgtagcag gttgcttttt
    10981 tatgataaaa gctgatgtaa tgaaggaaat cggttatttt gatgaaaatg tttttttata
    11041 taatgaagag aacattcttg gaatgaaact gagagaaaag ggcttccaat caattatatt
    11101 aaccaaacag ttttactatc atttgcatga ttttgaaaag gataaggtag aattatcctt
    11161 gagtaaaaaa tgtaaacgag attgggtgaa atttcagtca cgtaagtatt ttaccgaaaa
    11221 atattattca aaatttttag gttttcttct tttttttgtt gaaatattta atttgtttca
    11281 aattatgata ggacacttaa aaaataatat tataaagaag aatctgaaag gaaactctag
    11341 tgaaaaaaag tagtacgtta catagtagta cgttacatat agggcttatt ctttttttga
    11401 ttgtactgag taaaaacttc tttaatttag taccaaatat agcactgttt tctgatttta
    11461 atcttatgat tattataatc atcatgacag ttgttaatat taaatactat aatcgctcaa
    11521 ccaaatatca gtatcgttgg tatattattt ttacattgat atttgtgttg tatagtgcaa
    11581 ttaatgagaa actattatat ggccaaccat ttctattagg tttacttcct caaagacaat
    11641 tttttttatg tttaatgact tatttccctt taagaaagta tttccaagaa caaaatatta
    11701 gtttaaaaaa actttatgtt ggtattatga atttgggatc tatttcatcg ttaatttaca
    11761 ttttacaaaa gatagtaata ttatatgggg gaacacaatt tgttaacgta atgtatagtt
    11821 ttgccggata ttttagcggg tatagattgt atgtaggtag ttctttaatt attttagcaa
    11881 cattaatttc tactgcttat tttttagaaa cattaaaact caagtatctg tgccacctta
    11941 tattaggttg gtttactgaa atttggataa cgcaaggtcg aatagagatg attgttttgc
    12001 taatttcaac gatagtttgc ataatagtcc aaggaagatt aactagaaag aaaataattt
    12061 attggttgct gacaattttg ggactgtgga tgattactct aacacctatt tttgaaaata
    12121 ttgttggagc tattttaaaa gtagatggag caggtagagg aagtgattca ttgactattc
    12181 gagcaattgg acgacagtta tattgggatc aattgaatga gacaacttca aaacttcttt
    12241 ttggaacagg atatcctaat tataattatg ctttagcctt tcaacgtaca ggtttttcaa
    12301 gcaatatttt tttaacagac aatggtttta tgacatatat atatatattt ggtattgtgg
    12361 gttcctcaat tatgggatta ttatttttaa aatatcttaa aaattcaata aagtatgcta
    12421 gacaatctgc agatatgatt ccgttgatgt atattatttc tttactaatt gtagcctata
    12481 atattattct ttggtattgg aatgcggacg gtacttttat attagtaatc atgatttgcg
    12541 cattggagca tggagaacaa ttattacatc agaggaatgg agtgtgatta gatgaattta
    12601 aataaagaag ttagatggaa ggataagcaa tatattgctt ttgatttttt tgatacaact
    12661 atccatagaa attgtcatcc tgaagtgatt ttatttgaat ggtctaaaaa aatttctatt
    12721 tatttctctt tcaaaatatc tgctacagaa atttattcaa ttaggaaaaa atctgaaata
    12781 catgagaagc aagaaaaaca attggaagaa attaaatatg aaagattact tcaacttgtt
    12841 ttttatacta ttttaagtcg tttgaagtca gatgttaccg actatactct tgaagatttt
    12901 ttaatttatg caagaacgtg tgaagaggaa atagaattaa gacatattag tattgataca
    12961 gatacaatta attttattga atttttaaaa caaaatggga aaaaaataat tttaatttca
    13021 gatttttatt ctgataaaaa gctaattgaa aaattaatgg tttcattagg gattagagat
    13081 tatttctcta aaatatttat ttcaagtgaa attggcttac gtaagtcatc aggaaattta
    13141 tatgaatatg tgatcaatga attgagctgt aagcctataa atttacttat gattggtgat
    13201 aatatttatt ctgatgtaaa agttccaaaa aaactaggaa tagattctta tcataaatct
    13261 tattcagatt cacatgtgac tgtgagtcct aacgatattg taaaagcgat gaataatgtt
    13321 atttctcaag cttgtactga atctttattt aatctctata tacctgaaat actttatttt
    13381 atttcaaagt tatacaaaga attatctgtt aacaaagcta gtgatatatt attttgtgca
    13441 agagaaggtt tttttataaa aaaattattt gatctttatc aaaaaaaaat gaacttaaag
    13501 cttattaact cacattattt ttatgtttct agaaaatcaa cgctatatcc atcatttaaa
    13561 aatattgagg atgaagattt tgaagttatt tttagacaat ttcctgaaat tactttagaa
    13621 aattttttga ttaatttaaa tttttccaat aatgatatta acaatatttc taagcaaaca
    13681 gaaattaaac aaacagacaa agtatcagat aaatctatta ttaacaaatt aaaacaaaat
    13741 aaattattta aagatgttta tgatttgaac tgtaaagaag aaaaatattc ttttagagaa
    13801 tatttaaagt ctgtaggagt tgagaatgac aattctacaa taaatatggt agatattggt
    13861 tggaaaggca cgatacaaga caatattcaa aaagcttttc catctttaaa tataaaaggg
    13921 tattatatgg ggttgaattt tcaacggtat tctactagga atagtatgaa taagacggga
    13981 atactgttta ctgacgatcc tcaaaaaaca aagtttttta acttatttaa ttataaatat
    14041 ttattctatg aaagaatttt tgttgcagat catggaccga cagttagata tgaatttatg
    14101 aatggtgttg gggtaccaac attggataca gatgaaaatc atatagaaat ttatagattt
    14161 tctgaggaat ttcagattac atttttcaac acatttgaga aaattttaga tttgttcaat
    14221 gaatcactag taacaccaga tgaattattt aacgaaatag ctaatttatc gttaaaaaaa
    14281 cattgcatct atttacctag gctttcagta agtataaaaa aattagatag agcagcaaaa
    14341 gaaaattttg gtattataaa atctactaac aggaatagtg ataataaggt aagaaatttt
    14401 tggaaaaata gagatttttt atttttagat tatatatata aagcgtatgg aaagaataga
    14461 ttgttaaacc ctatattgga tatttacgga tattttgtat atctgattaa aacactgcaa
    14521 ataaaaatag taggggatat ttgatgagca tgaaagaaaa atcaataaat aaaaatgcta
    14581 ttttgaatat tattttaaca ctaacaaata ttgtgtttcc attaattact tttccttata
    14641 tttctagaat tctgaatccg tcaggaatag gtgcaatctc ttttttttca tctattggtt
    14701 cttatggtgt tttagttgcc tcgcttggaa tttcaactta tgggattcgg gtgattgcaa
    14761 aggatcgtta tcataaagat aagataacta aaatattcca agaattgata gttattaata
    14821 gtgtaatgtc tattatagtg acgttcttcc ttgttttaat gagtttccga ttagagcagt
    14881 taagttcaga aaaaggttta ttaataatca catgtattac tattttgtcc tctcctttta
    14941 atttgaattg gttttatagt ggaatagaag agtattcata tataacaaaa cgttcaatat
    15001 tttttaaatt agtttcattg atattaacct ttttatttgt taaaagtaaa gacgattata
    15061 ttctatatgc tgtgataaca ttgttttcaa cattggcttc caattttata aatattttgg
    15121 agagtagaaa atacatcaat tttaatttga gaagggattt agaatttaga tatcatctaa
    15181 aaccaatgtg gtatttattt gcttcgttac ttgcagttaa tatttatata aatttggatt
    15241 ctgtgatgtt aggaattatt aatggaaatg atgcggtagg tatttactca atcgcatcaa
    15301 aagtaaaatg gattttatta tcagtcgtta cttcagtgag ttcagtttta ttacccagat
    15361 tatcatttta tagcaataaa tatgacgaaa cgaagtttaa taatattttg agaaagtcat
    15421 ctacaataat ttttatgatt tcaattcctc taacaatttt ttttatgata aaagcgaaag
    15481 agagtatatt attgttaggt ggagagcagt atattcaggc agttttagca atgcaaatat
    15541 taatgccgat cttggtaata tcaggttttt ctaatattac aggtaatcag atattgatcc
    15601 ctactggtaa tgagaaatat tttatgagag cagtttctat aggagcaata gtaaatttat
    15661 gtttaaattt gttgcttatg cctattttgg gaattatcgg aggtgcgatc gcaactcttt
    15721 gtgcagaatc agtccaaatg attattcaat tttatttttc tcgtaataaa ttaatgggta
    15781 atatttcatt aaattcaatc aaaaaaatag cctattcatc aatttttgcg ggtatactgt
    15841 taatagtaat acaaaatatt atagagaatt ttaatagctt cttaaattta gctgcatcta
    15901 gttttctata ttttggagta tattttttct tattggtatt gtttaaagaa agtacaatta
    15961 agaaatttct aaatcaaatt ttttataagg atatttcatg aatttattac caattattta
    16021 tggagcgatt cttgatttaa tatcagaata attttttaaa gtgaatgaaa tcaaagcaat
    16081 aaaagattaa aaaataaatt gctatctatt atgtttttct caaactaagt aaaacataac
    16141 tcatgaaaac aaattaaaaa aggagggact atagtatgaa aggtattatt ctagcaggtg
    16201 gttcggggac acgtttatat cctttgactc gcgctgcatc aaaacaactt atgccggttt
    16261 atgataaacc gatgatttac tacccacttt caacattgat gttggctggg attagggata
    16321 ttttgattat ttccactcca caggatttac atcgattcca agagcttctt caagacggat
    16381 ctgagtttgg gctcaaactt tcttatgcag agcaaccaag tccagatggt ttggcacaag
    16441 cctttatcat tggggaagag tttatttctg atgatagcgt tgcgctgatc ttaggtgaca
    16501 atatctatca cggttctggg ctttccaaga tgctacaaaa ggcagcgagt aaggagtcgg
    16561 gagcaactgt ttttggctac catgtcaagg atccagagcg ctttggtgtg gttgagtttg
    16621 atcaggatat gaaggctatt tctattgaag aaaagccaga gcaccctcgt tcaaactatg
    16681 cagttacagg tctctatttc tatgataatg atgtagtaga gattgccaag agtattaaac
    16741 caagtcctcg tggtgaactg gaaattacag atgtaaacaa ggcttaccta gatcgtggtg
    16801 atttgtctgt tgagcttatg ggacgtggct ttgcttggtt ggatactggc actcatgaaa
    16861 gtttactaga ggcttcgcag tacatcgaaa cagtccaacg gatgcaaaat gttcaggtag
    16921 caaacttaga agaaattgct taccgtatgg gctatatcag tcgagaagat gtattggcct
    16981 tagcccaacc acttaagaaa aatgaatacg gacagtatct gctccgtttg attggagaag
    17041 catagatgac agataatttt ttcggtaaga cgcttgcggc acgcaaggtt gaagctattc
    17101 caggcatgtt ggagtttgat atccccgttc atggagataa tcgtggctgg tttaaagaaa
    17161 atttccaaaa ggaaaaaatg cttccacttg gatttccagc gtctttcttt gcagaaggaa
    17221 aattgcaaaa caatgtatcc ttctcacgta aaaatgtcct tcgaggcctc cacgcagagc
    17281 cttgggataa gtacatctct gtagcagatg gagggaaagt tctgggttct tgggttgatc
    17341 tacgcgaggg tgaaaccttt gggaatacct atcagacagt aattgatgca agcaagggaa
    17401 tctttgttcc tcgaggcgta gctaatggct tccaagtttt atcagataca gtgtcatata
    17461 gctatctggt caatgattac tgggcgcttg aactcaaacc caagtatgcc tttgtgaact
    17521 acgctgatcc aagccttggt attgaatggg aaaatattgc agaagcagag gtttcagaag
    17581 cagataaaca tcatccccta cttaaggacg tgaagccttt gaaaaaagaa gatttggaat
    17641 aaggaaagaa tatgactgaa tacaaaaata ttatcgtgac aggtggagct ggctttatcg
    17701 gttctaactt tgtccattat gtttacgaga actttccaga tgttcacgtg acagtcctag
    17761 ataagttgac ttatgctgga aaccgcgcga atattgagga aattttaggt agtcgtgttg
    17821 agttagttgt tggtgacatt gctgatgcgg agttggtaga caagttggct gctcaagcag
    17881 atgctatcgt tcattatgca gcggaaagcc acaatgataa ttcgctcaat gatccatcgc
    17941 catttattca tactaacttc attggaacct atactctttt agaagctgct cgtaagtatg
    18001 atattcgctt ccaccatgta tcgacagatg aagtttatgg ggatctccct ttacgcgaag
    18061 atttgccagg tcatggagaa gggccgggtg agaaatttac ggctgaaacc aagtacaatc
    18121 caagctcgcc ttactcatca accaaggcag cctcagattt gattgtcaaa gcctgggtgc
    18181 gttcttttgg agtcaaggca acgatttcca actgttcaaa taactacggt ccttaccagc
    18241 atattgagaa gtttattcca cgacaaatca ccaatatctt gagcggtatc aagccaaaac
    18301 tttacggtga aggtaagaac gttcgtgact ggattcatac caatgaccat tcttcaggag
    18361 tttggacaat cttgacaaaa gggcaaatcg gtgaaaccta cttgattggg gctgatggtg
    18421 agaagaacaa taaggaagtt ttggaactta tccttaagga aatgggacaa gctgcggatg
    18481 cctatgatca tgtgactgac cgtgcaggac atgaccttcg ctatgcgatt gatgctagca
    18541 agctccgtga tgagttgggg tggaaacctg aatttaccaa ctttgaagct gggctcaagg
    18601 caacaatcaa gtggtataca gataaccaag aatggtggaa agcagaaaaa gaagctgttg
    18661 aagccaatta tgctaagact caggagatta ttacagtata aaaagcagga aatagctgct
    18721 ttttattgct atattgggaa gagttacata ttagaaaggt ctagagatga ttttaattac
    18781 aggggcaaat ggccaattag gaacggaact tcgctattta ttggatgaac gtaatgaaga
    18841 atacgtggca gtagatgtgg ctaagatgga cattaccaat gaagaaatgg ttgagaaagt
    18901 ttttgaagag gtgaaaccga ctttagtcta ccattgtgca gcctacaccg ctgttgatgc
    18961 agcagaggat gaaggaaaag agttggactt cgccatcaat gtgacgggga caaaaaatgt
    19021 cgcaaaagca tctgaaaagc atggtgcaac tctagtttat atttctacgg actatgtctt
    19081 tgatggtaag aaaccagttg gacaagagtg ggaagttgat gaccgaccag atccacagac
    19141 agaatatgga cgcactaagc gtatggggga agagttagtt gagaagcatg tgtctaattt
    19201 ctatattatc cgtactgcct gggtatttgg aaattatggc aaaaacttcg tttttaccat
    19261 gcaaaatctt gcgaaaactc ataagacttt aacagttgta aatgaccagt acggtcgtcc
    19321 gacttggact cgtaccttgg ctgagttcat gacctaccta gctgaaaatc gtaaggaatt
    19381 tggttattat catttgtcaa atgatgcgac agaagataca acatggtatg attttgcagt
    19441 tgaaattttg aaagatacag atgtcgaagt caagccagta gattccagtc aatttccagc
    19501 caaagctaaa cgtccgctaa actcaacgat gagcctggcc aaagccaaag ctactggatt
    19561 tgttattcca acttggcaag atgcattgca agaattttac aaacaagaag tgagataagt
    19621 agtagaatga ttttctagtc taataaaaga ggcagagaat gaactccaaa ggagcttaag
    19681 atgtacgatt atcttgttgt tggtgcagtc tttgcccatg aagcagtctt aaaaggaaaa
    19741 aaagtaaaag ttattgaaaa atgaaatcat atcgcgggta atatctatac tcgtgaagag
    19801 gaaggaattc aagttcatca atatggtgct catatcttcc atacttctga taaggagatc
    19861 tgggattatg taaatcagtt tgcagacttt aaccgttata ccaattctcc tgttgcaaac
    19921 tataagggtg agatttataa ccttcctttt aatatgaata ccttcaataa actctgggga
    19981 gttgtgacgc cagcagaagc acaagctaag attgatgaac aacgtgctat tttaaatggt
    20041 aaaactcctg aaaatttgga agaacaggcg atttctcttg taggtacaga catctacgaa
    20101 aaattaatca aagactatac agagaaacag tggggcaaac caactactga acttccagcc
    20161 tttattattg tttgccagta cgcctgacct atgataacaa ctattttaac gatacctatc
    20221 aagggattcc aattggtgga tacactcaaa tagttgaaaa atgttggatc atgaaaatat
    20281 tgatgtagaa acaaatgttg atttctttgt gaataaagag caatatctga aagattttcc
    20341 taagattgtc tttactggta tgattgatga attctttgac tataagttgg gcgaactaga
    20401 gtaccgtagt cttcgttttg aaaatgagac cttggatatg gaaaattacc aaggaaatgc
    20461 agttgtgaac tatacggatg cagaaatccc atatactcgc attattgaac acaaacattt
    20521 tgagtttggg agtcaagcaa agactatcat tactaaagaa cattctaaaa catgggaaaa
    20581 aggtgatgag ccttattatc cagttaataa tgatcgtaat aatcatttgt ataaatcgta
    20641 taaaaaactt gctgatgagc aagggaatgt tatctttggt ggtcgcttag gacactatcg
    20701 ttattacgat atgcaccaag taattggagc agctttgcag tgcgtgagaa atgagttaga
    20761 ttaatactca atgaaaatca aagagcaaac taggaagcta gccacaggtt gctcaaaata
    20821 ctgttttgag gttgcagatg gaagctgacg cggtttgaag agattttcga agagtataaa
    20881 caagtaaaac tgactaccag ttattattta gaaatagtat taaaaattcc ttgactatgt
    20941 gatatagttg agggattttt aaatgatatt catatttttt gcaaagatgt tgtttgaaaa
    21001 ataattttca aaaattctga aaattctgtt gacaactttc tgaaaagagt ctataatgga
    21061 gagaaagttt taaaggagaa aatgatgaaa agttcaaaac tatttgccct tgcgggcgtg
    21121 acattattgg cggcgactac tttagctgca tgctctggat caggttcaag cactaaaggt
    21181 gagaagacat tctcatacat ttatgagaca gaccctgata acctcaacta tttgacaact
    21241 gctaaggctg cgacagcaaa tattaccagt aacgtggttg atggtttgct agaaaatgat
    21301 cgctacggga actttgtgcc gtctatggct gaggattggt ctgtatccaa ggatggattg
    21361 acttacactt atactatccg taaggatgca aaatggtata cttctgaagg tgaagaatac
    21421 gcggcagtca aagctcaaga c
//
